These Map2k4 knock-out mice exhibit liver abnormalities and suffer embryonic lethality. They may be useful for study of signal transduction in liver development.
Leonard I. Zon, Children's Hospital
Mice that are homozygous null for the Map2k4(SEK1, JNKK, or MKK4) gene exhibit liver abnormalities and suffer lethality before embryonic day 14.5. Histological examination reveals a reduced number of hepatocytes and enlarged, hemorrhaging sinuses. The donating investigator speculates that embryo death results from anemia brought on by massive bleeding. SEK1 is an enzyme in the stress-activated MAP kinase pathway.
|Allele Name||targeted mutation 1, Leonard I Zon|
|Allele Type||Targeted (Null/Knockout)|
|Gene Symbol and Name||Map2k4, mitogen-activated protein kinase kinase 4|
|Strain of Origin||129S1/Sv-Oca2+ Tyr+ Kitl+|
|Molecular Note||Insertion of a neomycin resistance cassette disrupted two exons encoding part of the catalytic domain of the protein. Western blots of embryonic fibroblasts from homozygous mutant mice showed no detectable protein for the targeted gene.|
|Mutations Made By|| |
Leonard Zon, Children's Hospital
When using the SEK1- mouse strain in a publication, please cite the originating article(s) and include JAX stock #003666 in your Materials and Methods section.