B6;129S1-Map2k4^tm1Lizon/J

Stock number: 003666
Product name: SEK1-
Research areas: Cancer Research, Developmental Biology Research, Hematological Research, Immunology, Inflammation and Autoimmunity Research, Internal/Organ Research

Description

These Map2k4 knock-out mice exhibit liver abnormalities and suffer embryonic lethality. They may be useful for study of signal transduction in liver development.

Detailed description

Mice that are homozygous null for the Map2k4(SEK1, JNKK, or MKK4) gene exhibit liver abnormalities and suffer lethality before embryonic day 14.5. Histological examination reveals a reduced number of hepatocytes and enlarged, hemorrhaging sinuses. The donating investigator speculates that embryo death results from anemia brought on by massive bleeding. SEK1 is an enzyme in the stress-activated MAP kinase pathway.

Allele

Symbol: Map2k4^tm1Lizon
Name: targeted mutation 1, Leonard I Zon
MGI accession ID: MGI:1861969
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Map2k4
Marker name: mitogen-activated protein kinase kinase 4
Chromosome: 11
Strain of origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺
Molecular note: Insertion of a neomycin resistance cassette disrupted two exons encoding part of the catalytic domain of the protein. Western blots of embryonic fibroblasts from homozygous mutant mice showed no detectable protein for the targeted gene.