Overview

This strain has been discontinued, please refer to Stock No. 000102 or to Stock No. 003215 or to Stock No. 006253

Genetic overview

Genetic Background	Generation

Ap3b1^pe-11J

Allele Type	Gene Symbol	Gene Name
Spontaneous	Ap3b1	adaptor-related protein complex 3, beta 1 subunit

H2-T18^b

Allele Type	Gene Symbol	Gene Name
Not Applicable (Not Applicable)	H2-T18	histocompatibility 2, T region locus 18

H2^r

Allele Type	Gene Symbol	Gene Name
Not Applicable	H2	histocompatibility-2, MHC

Marker(s)

	Marker Symbol	Marker Name
	H2	histocompatibility-2, MHC
	H2-T18	histocompatibility 2, T region locus 18

View Genetics

Research Applications

Dermatology Research
Hematological Research
Internal/Organ Research

View All Research Applications

Details

Control Suggestions

Heterozygote from the colony

Additional Information

Considerations for Choosing Controls

Genetics

Ap3b1^pe-11J

Allele Symbol: Ap3b1^pe-11J

Allele Name	pearl 11 Jackson
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Ap3b1, adaptor-related protein complex 3, beta 1 subunit
Gene Synonym(s)
Strain of Origin	B10.RIII-H2^r/(71NS)SnJ
Chromosome	13
General Note	This remutation arose spontaneously on the B10.RIII-H2r(71NS)/Sn strain. Homozygotes have lighter eye color at birth and a diluted gray coat color not different from the original pearl allele. Both homozygous males and females are fertile, and females are good mothers. Mice from this strain were not tested for differences in lysosomal enzymes or for platelet storage pool deficiency, both of which are common in other Ap3b1 mutations. DNA was saved from this remutation (J:51014, J:51188)
Molecular Note	The molecular lesion in pe^11J has not yet been resolved.

H2-T18^b

Allele Symbol: H2-T18^b

Allele Name	b variant
Allele Type	Not Applicable (Not Applicable)
Allele Synonym(s)	TL^-; Tla^b
Gene Symbol and Name	H2-T18, histocompatibility 2, T region locus 18
Gene Synonym(s)
Strain of Origin	Not Applicable
Chromosome	17
Molecular Note	The allele H2-T18^b determines absence of the antigen (TL^-) and occurs in strains C57BL/6, AKR, C3H/An, and many others.

H2^r

Allele Symbol: H2^r

Allele Name	r haplotype
Allele Type	Not Applicable
Allele Synonym(s)
Gene Symbol and Name	H2, histocompatibility-2, MHC
Gene Synonym(s)
Strain of Origin	RIII
Chromosome	17

H2

Marker Symbol: H2

Marker Synonym(s)
Chromosome(s)	17

H2-T18

Marker Symbol: H2-T18

Marker Synonym(s)
Chromosome(s)	17

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Ap3b1^pe-11J related

Dermatology Research
- Color and White Spotting Defects
Hematological Research
- Platelet Defects
  - platelet storage pool deficiency
Internal/Organ Research
- Kidney Defects
  - lysosomal enzyme abnormalities

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: Ap3b1^pe-11J/Ap3b1^pe-11J
B10.RIII H2 H2-T18/(71NS)Sn-Ap3b1/J

integument phenotype

diluted coat color
on the predominantly C57BL/10J background the coat color is light grey
(MGI Ref ID J:51188)

pigmentation phenotype

diluted coat color
on the predominantly C57BL/10J background the coat color is light grey
(MGI Ref ID J:51188)

References

Additional - Ap3b1^pe-11J related
Additional - H2 related
Additional - H2^r related
Additional - H2-T18 related
Additional - H2-T18^b related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols

Genotyping resources and troubleshooting

Mating System

heterozygote x homozygote or homozygote x heterozygot

Appearance

dark grey with much lighter ears, tail, and feet
Related Genotype: a/a Ap3b1^pe-11J/Ap3b1^pe-11J

black
Related Genotype: a/a Ap3b1^pe-11J/+

Terms Of Use

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

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Genetic overview

Marker(s)

Research Applications

Control Suggestions

Additional Information

Ap3b1pe-11J

Allele Symbol: Ap3b1pe-11J

H2-T18b

Allele Symbol: H2-T18b

H2r

Allele Symbol: H2r

H2

Marker Symbol: H2

H2-T18

Marker Symbol: H2-T18

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Ap3b1pe-11J related

Mammalian Phenotype Terms by Genotype

Genotype: Ap3b1pe-11J/Ap3b1pe-11JB10.RIII H2 H2-T18/(71NS)Sn-Ap3b1/J

integument phenotype

pigmentation phenotype

References

Additional - Ap3b1pe-11J related

Additional - H2 related

Additional - H2r related

Additional - H2-T18 related

Additional - H2-T18b related

Genotyping Protocols

Mating System

Appearance

Terms Of Use

Licensing Information

Ap3b1^pe-11J

Allele Symbol: Ap3b1^pe-11J

H2-T18^b

Allele Symbol: H2-T18^b

H2^r

Allele Symbol: H2^r

Genotype: Ap3b1^pe-11J related

Genotype: Ap3b1^pe-11J/Ap3b1^pe-11J
B10.RIII H2 H2-T18/(71NS)Sn-Ap3b1/J

Additional - Ap3b1^pe-11J related

Additional - H2^r related

Additional - H2-T18^b related