B10.RIII H2^r H2-T18^b/(71NS)Sn-Ap3b1^pe-11J/J

Stock number: 003599
Research areas: Dermatology Research, Hematological Research, Internal/Organ Research

Description

This strain has been discontinued, please refer to Stock No. 000102 or to Stock No. 003215 or to Stock No. 006253

Allele

Symbol: Ap3b1^pe-11J
Name: pearl 11 Jackson
MGI accession ID: MGI:1857892
Generation method: Spontaneous
Marker symbol: Ap3b1
Marker name: adaptor-related protein complex 3, beta 1 subunit
Chromosome: 13
Strain of origin: B10.RIII-H2^r/(71NS)SnJ
Molecular note: The molecular lesion in pe^11J has not yet been resolved.
General note: This remutation arose spontaneously on the B10.RIII-H2r(71NS)/Sn strain. Homozygotes have lighter eye color at birth and a diluted gray coat color not different from the original pearl allele. Both homozygous males and females are fertile, and females are good mothers. Mice from this strain were not tested for differences in lysosomal enzymes or for platelet storage pool deficiency, both of which are common in other Ap3b1 mutations. DNA was saved from this remutation (J:51014, J:51188)

Allele

Symbol: H2^r
Name: r haplotype
MGI accession ID: MGI:5780884
Generation method: Not Applicable
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17
Strain of origin: RIII

Allele

Symbol: H2-T18^b
Name: b variant
MGI accession ID: MGI:4820508
Generation method: Not Applicable
Attributes: Not Applicable
Marker symbol: H2-T18
Marker name: histocompatibility 2, T region locus 18
Chromosome: 17
Strain of origin: Not Applicable
Molecular note: The allele H2-T18^b determines absence of the antigen (TL^-) and occurs in strains C57BL/6, AKR, C3H/An, and many others.

Allele

MGI accession ID: MGI:95894
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17

Allele

MGI accession ID: MGI:95950
Marker symbol: H2-T18
Marker name: histocompatibility 2, T region locus 18
Chromosome: 17