B6.129-Htt^tm4Mem/J

Stock number: 003597
Product name: HdhQ92 KI
Research areas: Mouse/Human Gene Homologs, Neurobiology Research

Description

These Htt knock-in mice exhibit a Huntington's-like pathology.

Detailed description

This strain carries 92 CAG repeat units in the first exon of the endogenous Htt gene. Huntington's-like pathology is seen in the striatum, including nuclear localization of the protein, N-terminal inclusions, and insoluble aggregate formation. Instability of the length of the CAG repeat between generations is seen. Expression of this phenotype is delayed relative to Htt^tm5 (Stock No. 003456).

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Allele

Symbol: Htt^tm4Mem
Name: targeted mutation 4, Marcy E MacDonald
MGI accession ID: MGI:1861934
Generation method: Targeted
Attributes: Humanized sequence
Marker symbol: Htt
Marker name: huntingtin
Chromosome: 5
Strain of origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺
Molecular note: This allele carries 90 CAG repeat units, with 92 glutamines, in the first exon of the endogenous gene.