These Cdk5 knock-out mice exhibit unique lesions in the central nervous system associated with perinatal mortality. They are suitable for use in applications related to the study of brain development and neuronal differentiation.
The Jackson Laboratory
Cdk5 is an important molecule for brain development and neuronal differentiation. Cdk null mice exhibit unique lesions in the central nervous system associated with perinatal mortality. The brains of mutant mice lack cortical laminar structure and cerebellar foliation. The large neurons in the brain stem and in the spinal cord show chromatolytic changes with accumulation of neurofilament immunoreactivity. They also exhibit neuronal migration abnormalities, cerebellar defoliation, NF accumulation neuronal bodies, and degenerated motor neurons.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
|Allele Name||targeted mutation 1, Ashok B Kulkarni|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||Cdk5 (-)|
|Gene Symbol and Name||Cdk5, cyclin-dependent kinase 5|
|Strain of Origin||129S4/SvJae|
|Molecular Note||Replacement of part of exon III, exons IV and V with a neomycin cassette.|
|Mutations Made By|| |
Ashok Kulkarni, NIDCR NIH
When maintaining a live colony, heterozygous mice may be bred to wildtype siblings, or to C57BL/6J inbred mice (Stock No. 000664). Homozygous mice either die in utero or within 12 hours after birth.
When using the Cdk5- mouse strain in a publication, please cite the originating article(s) and include JAX stock #003596 in your Materials and Methods section.