JAX
Mouse Strain Datasheet - 003573
B6.Cg-Tg(Ins2-cre)25Mgn/J
Also Known As: Rip-cre
The RIP-Cre transgene has a 668 bp fragment of the rat insulin II promoter, nuclear-localized Cre recombinase, and a 2.1 kbp fragment from the human growth hormone gene. These RIP-Cre transgenic mice are a Cre-lox tool useful for deletion of floxed sequences in pancreatic beta cells.
Donating Investigator
Mark A. Magnuson, Vanderbilt University School of Medicine
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N12+1F18
(22-JAN-09) |
Tg(Ins2-cre)25Mgn
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Detailed Description
This strain carries the "RIP-Cre" transgene construct (containing a 668 bp fragment of the rat insulin II promoter, Cre recombinase with a nuclear localization sequence, and a 2.1 kb fragment from the human growth hormone gene). Hemizygous mice carrying this transgene are phenotypically normal and overexpresss cre specifically in pancreatic beta cells. This transgene strain is used in combination with mice carrying floxed targeted mutations to create various pancreatic beta cell-specific gene knockouts using the "Cre-lox" system. Results from several different laboratories have shown that this transgenic strain is at least 85% efficient in achieving pancreatic beta cell-specific recombination. It should also be noted that the transgene in this line has been found to be expressed at a low level in the hypothalamus. In some cases this has resulted in a phenotype due to deletion of the floxed allele in this region of the brain. It has also been shown that these transgenic mice may spontaneously develop glucose intolerance and impaired insulin secretion developing at 6-8 weeks of age. It is recommended that users include naive "RIP-Cre" mice (i.e., those not bred to a floxed mutant) among the controls used in experiments.
Development
A transgenic construct containing a 668 bp rat insulin II promoter, nuclear localization sequence-modified Cre recombinase and a 2.1 kbp fragment from the human growth hormone gene was injected into B6D2(F2) pronuclei. The allele was subsequently moved to a C57BL/6J background.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | pancreatic beta cells |
Control Suggestions
Selected References
- Postic C; Shiota M; Niswender KD; Jetton TL; Chen Y; Moates JM; Shelton KD; Lindner J; Cherrington AD; Magnuson MA. 1999. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274(1):305-15. PubMed: 9867845MGI: J:51826
Tg(Ins2-cre)25Mgn
Allele Symbol: Tg(Ins2-cre)25Mgn
| Allele Name | transgene insertion 25, Mark A Magnuson |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Ins-Cre; Ins2cre; M line; RIP Cre; RIP2-cre; RIP2Cre; RIPCre; Rip-cre; TgN(ins2-Cre)25Mgn; [RIP]-Cre |
| Gene Symbol and Name | Tg(Ins2-cre)25Mgn, transgene insertion 25, Mark A Magnuson |
| Gene Synonym(s) | Ins-Cre; Ins2cre; RIP Cre; RIP2-cre; Rip-cre; [RIP]-Cre |
| Promoter | Ins2, insulin 2, rat |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | pancreatic beta cells |
| Strain of Origin | (C57BL/6 x DBA)F2 |
| Chromosome | UN |
| Molecular Note | This transgene expresses Cre recombinase under the control of the rat insulin promoter (Ins2), which is active in pancreatic beta cells and in neurons of the hypothalamus. 9 copies of the transgene are estimated to be present. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Diabetes and Obesity Research
- Type 1 Diabetes (IDDM)
- Research Tools
- Cardiovascular Research
- Cre-lox System
- Cre-lox System
- Cre Recombinase Expression
- Diabetes and Obesity Research
- loxP
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Tissue/Cell Markers: Cre-lox System
- Tissue/Cell Markers: pancreatic beta cells
- Cardiovascular Research
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
References
- Postic C; Shiota M; Niswender KD; Jetton TL; Chen Y; Moates JM; Shelton KD; Lindner J; Cherrington AD; Magnuson MA. 1999. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274(1):305-15. PubMed: 9867845MGI: J:51826
Additional References
- Crabtree JS; Scacheri PC; Ward JM; McNally SR; Swain GP; Montagna C; Hager JH; Hanahan D; Edlund H; Magnuson MA; Garrett-Beal L; Burns AL; Ried T; Chandrasekharappa SC; Marx SJ; Spiegel AM; Collins FS. 2003. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol 23(17):6075-85. PubMed: 12917331MGI: J:85042
- Gannon M; Shiota C; Postic C; Wright CV; Magnuson M. 2000. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis 26(2):139-42. PubMed: 10686610MGI: J:69314
- Gorogawa S; Fujitani Y; Kaneto H; Hazama Y; Watada H; Miyamoto Y; Takeda K; Akira S; Magnuson MA; Yamasaki Y; Kajimoto Y; Hori M. 2004. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem Biophys Res Commun 319(4):1159-70. PubMed: 15194489MGI: J:90753
- Martin J; Hunt SL; Dubus P; Sotillo R; Nehme-Pelluard F; Magnuson MA; Parlow AF; Malumbres M; Ortega S; Barbacid M. 2003. Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene 22(34):5261-9. PubMed: 12917627MGI: J:85130
- Rosen ED; Kulkarni RN; Sarraf P; Ozcan U; Okada T; Hsu CH; Eisenman D; Magnuson MA; Gonzalez FJ; Kahn CR; Spiegelman BM. 2003. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol 23(20):7222-9. PubMed: 14517292MGI: J:89959
- Schulla V; Renstrom E; Feil R; Feil S; Franklin I; Gjinovci A; Jing XJ; Laux D; Lundquist I; Magnuson MA; Obermuller S; Olofsson CS; Salehi A; Wendt A; Klugbauer N; Wollheim CB; Rorsman P; Hofmann F. 2003. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J 22(15):3844-54. PubMed: 12881419MGI: J:84919
Additional - Tg(Ins2-cre)25Mgn related
- Abe H; Uchida T; Hara A; Mizukami H; Komiya K; Koike M; Shigihara N; Toyofuku Y; Ogihara T; Uchiyama Y; Yagihashi S; Fujitani Y; Watada H. 2013. Exendin-4 improves beta-cell function in autophagy-deficient beta-cells. Endocrinology 154(12):4512-24. PubMed: 24105478MGI: J:205147
- Antonson P; Nalvarte I; Varshney M; Xu L; Windahl SH; Humire P; Ohlsson C; Gustafsson JA; Dahlman-Wright K. 2015. Identification of proteins highly expressed in uterine fluid from mice with hydrometra. Biochem Biophys Res Commun 466(4):650-5. PubMed: 26393907MGI: J:232939
- Apostolou I; Hao Z; Rajewsky K; von Boehmer H. 2003. Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes. J Exp Med 198(7):1103-6. PubMed: 14530378MGI: J:85985
- Appelbe OK; Yevtodiyenko A; Muniz-Talavera H; Schmidt JV. 2013. Conditional deletions refine the embryonic requirement for Dlk1. Mech Dev 130(2-3):143-59. PubMed: 23059197MGI: J:194130
- Atouf F; Park CH; Pechhold K; Ta M; Choi Y; Lumelsky NL. 2007. No evidence for mouse pancreatic beta-cell epithelial-mesenchymal transition in vitro. Diabetes 56(3):699-702. PubMed: 17327438MGI: J:122025
- Bardoux P; Zhang P; Flamez D; Perilhou A; Lavin TA; Tanti JF; Hellemans K; Gomas E; Godard C; Andreelli F; Buccheri MA; Kahn A; Le Marchand-Brustel Y; Burcelin R; Schuit F; Vasseur-Cognet M. 2005. Essential Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor II in Insulin Secretion and Insulin Sensitivity Revealed by Conditional Gene Knockout. Diabetes 54(5):1357-1363. PubMed: 15855320MGI: J:98195
- Beall C; Piipari K; Al-Qassab H; Smith MA; Parker N; Carling D; Viollet B; Withers DJ; Ashford ML. 2010. Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem J 429(2):323-33. PubMed: 20465544MGI: J:164464
- Biondi CA; Gartside MG; Waring P; Loffler KA; Stark MS; Magnuson MA; Kay GF; Hayward NK. 2004. Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol Cell Biol 24(8):3125-31. PubMed: 15060136MGI: J:89898
- Blum B; Roose AN; Barrandon O; Maehr R; Arvanites AC; Davidow LS; Davis JC; Peterson QP; Rubin LL; Melton DA. 2014. Reversal of beta cell de-differentiation by a small molecule inhibitor of the TGFbeta pathway. Elife 3:e02809. PubMed: 25233132MGI: J:218054
- Brissova M; Shostak A; Shiota M; Wiebe PO; Poffenberger G; Kantz J; Chen Z; Carr C; Jerome WG; Chen J; Baldwin HS; Nicholson W; Bader DM; Jetton T; Gannon M; Powers AC. 2006. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes 55(11):2974-85. PubMed: 17065333MGI: J:116552
- Brouwers B; de Faudeur G; Osipovich AB; Goyvaerts L; Lemaire K; Boesmans L; Cauwelier EJ; Granvik M; Pruniau VP; Van Lommel L; Van Schoors J; Stancill JS; Smolders I; Goffin V; Binart N; In't Veld P; Declercq J; Magnuson MA; Creemers JW; Schuit F; Schraenen A. 2014. Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression. Cell Metab 20(6):979-90. PubMed: 25470546MGI: J:215816
- Brunham LR; Kruit JK; Pape TD; Timmins JM; Reuwer AQ; Vasanji Z; Marsh BJ; Rodrigues B; Johnson JD; Parks JS; Verchere CB; Hayden MR. 2007. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat Med 13(3):340-7. PubMed: 17322896MGI: J:121696
- Cai EP; Casimir M; Schroer SA; Luk CT; Shi SY; Choi D; Dai XQ; Hajmrle C; Spigelman AF; Zhu D; Gaisano HY; MacDonald PE; Woo M. 2012. In vivo role of focal adhesion kinase in regulating pancreatic beta-cell mass and function through insulin signaling, actin dynamics, and granule trafficking. Diabetes 61(7):1708-18. PubMed: 22498697MGI: J:203602
- Cantley J; Choudhury AI; Asare-Anane H; Selman C; Lingard S; Heffron H; Herrera P; Persaud SJ; Withers DJ. 2007. Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologia 50(6):1248-56. PubMed: 17393136MGI: J:141585
- Cantley J; Selman C; Shukla D; Abramov AY; Forstreuter F; Esteban MA; Claret M; Lingard SJ; Clements M; Harten SK; Asare-Anane H; Batterham RL; Herrera PL; Persaud SJ; Duchen MR; Maxwell PH; Withers DJ. 2009. Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J Clin Invest 119(1):125-35. PubMed: 19065050MGI: J:144713
- Cape A; Chen X; Wang CE; O'Neill A; Lin YF; He J; Xu XS; Yi H; Li H; Li S; Li XJ. 2012. Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic beta-cells. Cell Mol Life Sci 69(8):1305-17. PubMed: 21544547MGI: J:196050
- Carrington EM; McKenzie MD; Jansen E; Myers M; Fynch S; Kos C; Strasser A; Kay TW; Scott CL; Allison J. 2009. Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli. Diabetes 58(10):2316-23. PubMed: 19581414MGI: J:154403
- Casanovas O; Hager JH; Chun MG; Hanahan D. 2005. Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis. Oncogene 24(44):6597-604. PubMed: 16007165MGI: J:101759
- Chakravarthy MV; Zhu Y; Lopez M; Yin L; Wozniak DF; Coleman T; Hu Z; Wolfgang M; Vidal-Puig A; Lane MD; Semenkovich CF. 2007. Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest 117(9):2539-52. PubMed: 17694178MGI: J:127482
- Chakravarthy MV; Zhu Y; Yin L; Coleman T; Pappan KL; Marshall CA; McDaniel ML; Semenkovich CF. 2009. Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation. J Lipid Res 50(4):630-40. PubMed: 19029118MGI: J:158085
- Chamberlain CE; Scheel DW; McGlynn K; Kim H; Miyatsuka T; Wang J; Nguyen V; Zhao S; Mavropoulos A; Abraham AG; O'Neill E; Ku GM; Cobb MH; Martin GR; German MS. 2014. Menin determines K-RAS proliferative outputs in endocrine cells. J Clin Invest 124(9):4093-101. PubMed: 25133424MGI: J:215828
- Chase LG; Ulloa-Montoya F; Kidder BL; Verfaillie CM. 2007. Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells. Diabetes 56(1):3-7. PubMed: 17110468MGI: J:121938
- Chen J; Fontes G; Saxena G; Poitout V; Shalev A. 2010. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes 59(2):440-7. PubMed: 19875615MGI: J:164164
- Chen J; Hui ST; Couto FM; Mungrue IN; Davis DB; Attie AD; Lusis AJ; Davis RA; Shalev A. 2008. Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB J 22(10):3581-94. PubMed: 18552236MGI: J:140264
- Choi D; Cai EP; Schroer SA; Wang L; Woo M. 2011. Vhl is required for normal pancreatic beta cell function and the maintenance of beta cell mass with age in mice. Lab Invest 91(4):527-38. PubMed: 21242957MGI: J:170625
- Choi D; Nguyen KT; Wang L; Schroer SA; Suzuki A; Mak TW; Woo M. 2008. Partial deletion of Pten in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone. Endocrinology 149(9):4382-6. PubMed: 18499759MGI: J:145502
- Choi D; Schroer SA; Lu SY; Wang L; Wu X; Liu Y; Zhang Y; Gaisano HY; Wagner KU; Wu H; Retnakaran R; Woo M. 2010. Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. J Exp Med 207(13):2831-42. PubMed: 21149549MGI: J:176862
- Choudhury AI; Heffron H; Smith MA; Al-Qassab H; Xu AW; Selman C; Simmgen M; Clements M; Claret M; Maccoll G; Bedford DC; Hisadome K; Diakonov I; Moosajee V; Bell JD; Speakman JR; Batterham RL; Barsh GS; Ashford ML; Withers DJ. 2005. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115(4):940-950. PubMed: 15841180MGI: J:97406
- Covey SD; Wideman RD; McDonald C; Unniappan S; Huynh F; Asadi A; Speck M; Webber T; Chua SC; Kieffer TJ. 2006. The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab 4(4):291-302. PubMed: 17011502MGI: J:129737
- Crabtree JS; Scacheri PC; Ward JM; McNally SR; Swain GP; Montagna C; Hager JH; Hanahan D; Edlund H; Magnuson MA; Garrett-Beal L; Burns AL; Ried T; Chandrasekharappa SC; Marx SJ; Spiegel AM; Collins FS. 2003. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol 23(17):6075-85. PubMed: 12917331MGI: J:85042
- Cui J; Wang Z; Cheng Q; Lin R; Zhang XM; Leung PS; Copeland NG; Jenkins NA; Yao KM; Huang JD. 2011. Targeted inactivation of kinesin-1 in pancreatic beta-cells in vivo leads to insulin secretory deficiency. Diabetes 60(1):320-30. PubMed: 20870970MGI: J:170198
- Cui Y; Huang L; Elefteriou F; Yang G; Shelton JM; Giles JE; Oz OK; Pourbahrami T; Lu CY; Richardson JA; Karsenty G; Li C. 2004. Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol 24(1):258-69. PubMed: 14673160MGI: J:87596
- Dabernat S; Secrest P; Peuchant E; Moreau-Gaudry F; Dubus P; Sarvetnick N. 2009. Lack of beta-catenin in early life induces abnormal glucose homeostasis in mice. Diabetologia 52(8):1608-17. PubMed: 19513688MGI: J:150423
- Dai C; Huh CG; Thorgeirsson SS; Liu Y. 2005. {beta}-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance. Am J Pathol 167(2):429-36. PubMed: 16049329MGI: J:99948
- Dieguez-Hurtado R; Martin J; Martinez-Corral I; Martinez MD; Megias D; Olmeda D; Ortega S. 2011. A Cre-reporter transgenic mouse expressing the far-red fluorescent protein Katushka. Genesis 49(1):36-45. PubMed: 21254335MGI: J:167974
- Ebato C; Uchida T; Arakawa M; Komatsu M; Ueno T; Komiya K; Azuma K; Hirose T; Tanaka K; Kominami E; Kawamori R; Fujitani Y; Watada H. 2008. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 8(4):325-32. PubMed: 18840363MGI: J:143423
- Ebert G; Preston S; Allison C; Cooney J; Toe JG; Stutz MD; Ojaimi S; Scott HW; Baschuk N; Nachbur U; Torresi J; Chin R; Colledge D; Li X; Warner N; Revill P; Bowden S; Silke J; Begley CG; Pellegrini M. 2015. Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Proc Natl Acad Sci U S A 112(18):5797-802. PubMed: 25902529MGI: J:221325
- El-Gohary Y; Tulachan S; Wiersch J; Guo P; Welsh C; Prasadan K; Paredes J; Shiota C; Xiao X; Wada Y; Diaz M; Gittes G. 2014. A smad signaling network regulates islet cell proliferation. Diabetes 63(1):224-36. PubMed: 24089514MGI: J:209044
- Engin F; Yermalovich A; Nguyen T; Hummasti S; Fu W; Eizirik DL; Mathis D; Hotamisligil GS. 2013. Restoration of the unfolded protein response in pancreatic beta cells protects mice against type 1 diabetes. Sci Transl Med 5(211):211ra156. PubMed: 24225943MGI: J:213542
- Fan Y; Rudert WA; Grupillo M; He J; Sisino G; Trucco M. 2009. Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J 28(18):2812-24. PubMed: 19680229MGI: J:152798
- Fex M; Haemmerle G; Wierup N; Dekker-Nitert M; Rehn M; Ristow M; Zechner R; Sundler F; Holm C; Eliasson L; Mulder H. 2009. A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis. Diabetologia 52(2):271-80. PubMed: 19023560MGI: J:144744
- Fex M; Wierup N; Nitert MD; Ristow M; Mulder H. 2007. Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance. J Endocrinol 194(3):551-5. PubMed: 17761894MGI: J:145236
- Fujioka M; Tokano H; Fujioka KS; Okano H; Edge AS. 2011. Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation. J Clin Invest 121(6):2462-9. PubMed: 21576819MGI: J:173515
- Gannon M; Ables ET; Crawford L; Lowe D; Offield MF; Magnuson MA; Wright CV. 2008. pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 314(2):406-17. PubMed: 18155690MGI: J:130389
- Gannon M; Shiota C; Postic C; Wright CV; Magnuson M. 2000. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis 26(2):139-42. PubMed: 10686610MGI: J:69314
- Gautam D; Han SJ; Hamdan FF; Jeon J; Li B; Li JH; Cui Y; Mears D; Lu H; Deng C; Heard T; Wess J. 2006. A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab 3(6):449-61. PubMed: 16753580MGI: J:129643
- Genetic Resource Science at The Jackson Laboratory. 2008. Expression/Specificity Patterns of Cre Alleles Direct Data Submission from Genetic Resource Science :. MGI: J:137887
- Genetic Resource Science at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013 Direct Data Submission from Genetic Resource Science :. MGI: J:193672
- Gorogawa S; Fujitani Y; Kaneto H; Hazama Y; Watada H; Miyamoto Y; Takeda K; Akira S; Magnuson MA; Yamasaki Y; Kajimoto Y; Hori M. 2004. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem Biophys Res Commun 319(4):1159-70. PubMed: 15194489MGI: J:90753
- Gu Y; Lindner J; Kumar A; Yuan W; Magnuson MA. 2011. Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes 60(3):827-37. PubMed: 21266327MGI: J:170129
- Gupta RK; Gao N; Gorski RK; White P; Hardy OT; Rafiq K; Brestelli JE; Chen G; Stoeckert CJ Jr; Kaestner KH. 2007. Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. Genes Dev 21(7):756-69. PubMed: 17403778MGI: J:120377
- Gupta RK; Vatamaniuk MZ; Lee CS; Flaschen RC; Fulmer JT; Matschinsky FM; Duncan SA; Kaestner KH. 2005. The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. J Clin Invest 115(4):1006-1015. PubMed: 15761495MGI: J:97364
- Hager JH; Ulanet DB; Hennighausen L; Hanahan D. 2009. Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer. PLoS One 4(2):e4455. PubMed: 19209227MGI: J:146436
- Harb G; Vasavada RC; Cobrinik D; Stewart AF. 2009. The retinoblastoma protein and its homolog p130 regulate the G1/S transition in pancreatic beta-cells. Diabetes 58(8):1852-62. PubMed: 19509021MGI: J:154413
- Hardy AB; Prentice KJ; Froese S; Liu Y; Andrews GK; Wheeler MB. 2015. Zip4 mediated zinc influx stimulates insulin secretion in pancreatic beta cells. PLoS One 10(3):e0119136. PubMed: 25806541MGI: J:229178
- Hardy AB; Wijesekara N; Genkin I; Prentice KJ; Bhattacharjee A; Kong D; Chimienti F; Wheeler MB. 2012. Effects of high-fat diet feeding on Znt8-null mice: differences between beta-cell and global knockout of Znt8. Am J Physiol Endocrinol Metab 302(9):E1084-96. PubMed: 22338079MGI: J:186864
- Harris JA; Hirokawa KE; Sorensen SA; Gu H; Mills M; Ng LL; Bohn P; Mortrud M; Ouellette B; Kidney J; Smith KA; Dang C; Sunkin S; Bernard A; Oh SW; Madisen L; Zeng H. 2014. Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits 8:76. PubMed: 25071457MGI: J:220523
- Hasegawa K; Wakino S; Kimoto M; Minakuchi H; Fujimura K; Hosoya K; Komatsu M; Kaneko Y; Kanda T; Tokuyama H; Hayashi K; Itoh H. 2013. The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice. FASEB J 27(6):2301-15. PubMed: 23430976MGI: J:199962
- Hashimoto N; Kido Y; Uchida T; Matsuda T; Suzuki K; Inoue H; Matsumoto M; Ogawa W; Maeda S; Fujihara H; Ueta Y; Uchiyama Y; Akimoto K; Ohno S; Noda T; Kasuga M. 2005. PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J Clin Invest 115(1):138-45. PubMed: 15630453MGI: J:95378
- Hassler JR; Scheuner DL; Wang S; Han J; Kodali VK; Li P; Nguyen J; George JS; Davis C; Wu SP; Bai Y; Sartor M; Cavalcoli J; Malhi H; Baudouin G; Zhang Y; Yates Iii JR; Itkin-Ansari P; Volkmann N; Kaufman RJ. 2015. The IRE1alpha/XBP1s Pathway Is Essential for the Glucose Response and Protection of beta Cells. PLoS Biol 13(10):e1002277. PubMed: 26469762MGI: J:226385
- Hinke SA; Navedo MF; Ulman A; Whiting JL; Nygren PJ; Tian G; Jimenez-Caliani AJ; Langeberg LK; Cirulli V; Tengholm A; Dell'Acqua ML; Santana LF; Scott JD. 2012. Anchored phosphatases modulate glucose homeostasis. EMBO J 31(20):3991-4004. PubMed: 22940692MGI: J:190017
- Hisadome K; Smith MA; Choudhury AI; Claret M; Withers DJ; Ashford ML. 2009. 5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus. Neuroscience 159(1):83-93. PubMed: 19135134MGI: J:148970
- Inoue M; Hager JH; Ferrara N; Gerber HP; Hanahan D. 2002. VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell 1(2):193-202. PubMed: 12086877MGI: J:77131
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