This MMTV-Cre Line A transgenic strain expresses P1 Cre recombinase under the control of the MMTV LTR promoter. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, and various cells of the immune system. MMTV-Cre Line A also expresses cre in the female germline. Little background recombination was observed in the lung, kidney, liver and brain tissues. 
 The donating investigator indicates that MMTV-Cre Line A may be suitable for use in applications where it is desirable to delete genes in the virgin and lactating mammary gland, and other secretory tissues. Furthermore, its Cre recombinase activity in female germline allows it to be utilized to generate a knock-out allele from a targeted locus with loxP sites with an efficiency of 100%.
 Of note, also available is MMTV-Cre Line D (Stock No. <a href="https://www.jax.org/strain/003553">003553</a>) that has some similarities, but is not reported to have any significant expression in oocytes.

These MMTV-Cre/Line A mice express a transgene containing the MMTV LTR promoter directing expression of Cre recombinase. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, and various cells of the immune system. MMTV-Cre Line A also expresses cre in the female germline.
 Of note, also available is MMTV-Cre Line D (Stock No. <a href="https://www.jax.org/strain/003553">003553</a>) that has some similarities, but is not reported to have any significant expression in oocytes.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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