| Allele Name | transgene insertion 1, Lothar Hennighausen |
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | A1 line; A-line; CreA; MMTV Cre line A; MMTV-Cre; MMTV-CrelineA; MMTV-CreA |
| Gene Symbol and Name | Tg(MMTV-cre)1Mam, transgene insertion 1, Lothar Hennighausen |
| Gene Synonym(s) | |
| Promoter | MMTV, Mouse Mammary Tumor Virus, MMTV |
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| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
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| Site of Expression | widespread pattern of expression including the female germline; high levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, and various cells of the immune system; little background recombination was observed in the lung, kidney, liver and brain tissues |
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| Strain of Origin | FVB |
| Chromosome | UN |
| General Note | This transgene is the A line. Line 4 (D) and line F were also produced. |
| Molecular Note | This transgene directs the expression of Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat. The viral MMTV promoter directed expression of Cre recombinase in the secretory epithelium of the mammary gland, the salivary gland and in the female germline. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, and various cells of the immune system. Little background recombination was observed in the lung, kidney, liver and brain tissues. |
| Mutations Made By | Dr. Kay-Uwe Wagner, University of Nebraska Medical Center |
