Cdk5 is an important molecule for brain development and neuronal differentiation. <i>Cdk</i> null mice exhibit unique lesions in the central nervous system associated with perinatal mortality. The brains of mutant mice lack cortical laminar structure and cerebellar foliation. The large neurons in the brain stem and in the spinal cord show chromatolytic changes with accumulation of neurofilament immunoreactivity. They also exhibit neuronal migration abnormalities, cerebellar defoliation, NF accumulation neuronal bodies, and degenerated motor neurons.

These <i> Cdk </i> knock-out mice exhibit unique lesions in the central nervous system associated with perinatal mortality.  They are suitable for use in applications related to the study of brain development, neuronal differentiation, and neuronal cytoskeleton structure and organization.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.