B6;C-Npr3^lgj/J

Stock number: 003506
Product name: longjohn
Research areas: Developmental Biology Research

Detailed description

These mice carry a spontaneous mutation at the Npr3 locus characterized by longer overall body length and digits and an elongated, conical extension of the body at the base of the tail.

Development

The longjohn (lgj) mutation arose spontaneously in 1979 on the BALB/cJ background at The Jackson Laboratory (Jaubert, J. et al.). In 1999 an outcross to C57BL/6J was done and the N1F1 males were then bred with C57BL/6J females to generate embryos for cryopreservation.

Allele

Symbol: Npr3^lgj
Name: longjohn
MGI accession ID: MGI:1857837
Generation method: Spontaneous
Synonyms: lgj
Marker symbol: Npr3
Marker name: natriuretic peptide receptor 3
Chromosome: 15
Strain of origin: BALB/cJ
Molecular note: An in-frame 36 bp deletion of coding nucleotides 196-231 (c.196_231del) deletes 12 amino acids in the extracellular domain of the encoded peptide (p.(Arg66_Ser77del)) that are highly conserved among species.
General note: Genbank: AF131862