These mice carry a spontaneous mutation at the Npr3 locus characterized by longer overall body length and digits and an elongated, conical extension of the body at the base of the tail.
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Npr3 | natriuretic peptide receptor 3 |
These mice carry a spontaneous mutation at the Npr3 locus characterized by longer overall body length and digits and an elongated, conical extension of the body at the base of the tail.
The longjohn (lgj) mutation arose spontaneously in 1979 on the BALB/cJ background at The Jackson Laboratory (Jaubert, J. et al.). In 1999 an outcross to C57BL/6J was done and the N1F1 males were then bred with C57BL/6J females to generate embryos for cryopreservation.
Allele Name | longjohn |
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Allele Type | Spontaneous |
Allele Synonym(s) | lgj |
Gene Symbol and Name | Npr3, natriuretic peptide receptor 3 |
Gene Synonym(s) | |
Strain of Origin | BALB/cJ |
Chromosome | 15 |
General Note | Genbank: AF131862 |
Molecular Note | An in-frame 36 bp deletion of coding nucleotides 196-231 (c.196_231del) deletes 12 amino acids in the extracellular domain of the encoded peptide (p.(Arg66_Ser77del)) that are highly conserved among species. |
Homozygous Npr3lgj/Npr3lgj mice can be identified by six days of age based on their longer overall body length and digits and an elongated, conical extension of the body at the base of the tail. Food needs to be added to the bottom of the cage for homozygotes.
When using the longjohn mouse strain in a publication, please cite the originating article(s) and include JAX stock #003506 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Npr3<lgj> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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