JAX
Mouse Strain Datasheet - 003448
CByJ.129P2(B6)-Tcrdtm1Mom/Sz
Also Known As: BALB/cBy TCRdelta-, BALB/cByJ-Tcrd
These Tcrd knock-out mice exhibit deficiency of gamma delta T-cell receptor expression.
Read More +Genetic overview
| Genetic Background | Generation |
|---|---|
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Tcrdtm1Mom
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Tcrd | T cell receptor delta chain |
Research Applications
- Hematological Research
- Immunology, Inflammation and Autoimmunity Research
- Research Tools
Detailed Description
Mice homozygous for this targeted mutation are viable and fertile. Gamma delta T-cell receptor expression is deficient in all adult lymphoid and epithelial organs. There is normal development of the alpha beta T-cell lineage. Patterns of CD4+CD8- and CD4-CD8+ alpha beta T-cells are apparently normal. Mice do not develop inflammatory bowel disease.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
This targeted mutant strain was developed by Dr. Peter Mombaerts in the laboratory of Dr. Susumu Tonegawa at the Center for Cancer Research, Massachusetts Institute of Technology. A replacement targeting vector containing Pgk-neo was used which resulted in a 4 kb deletion encompassing most of the delta chain constant region coding sequences. This strain was generated in the laboratory of Dr. Leonard Shultz by backcrossing mice from B6.1292-Tcrdtm1Mom/J to BALB/cByJ inbred mice for a minimum of 9 generations.
Selected References
- Itohara S; Mombaerts P; Lafaille J; Iacomini J; Nelson A; Clarke AR; Hooper ML; Farr A; Tonegawa S. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.. In: . . MGI: J:3865
Tcrdtm1Mom
Allele Symbol: Tcrdtm1Mom
| Allele Name | targeted mutation 1, Peter Mombaerts |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | C-delta-; TCRdelta KO; TCRdelta-; delta-; delta0; gammadelta TCR- |
| Gene Symbol and Name | Tcrd, T cell receptor delta chain |
| Gene Synonym(s) | Tcr delta; Tcrdelta |
| Strain of Origin | 129P2/OlaHsd |
| Chromosome | 14 |
| Molecular Note | A PGK-neo cassette was used to disrupt the constant gene segment (designated C-delta). Flow cytometry showed that cells isolated from the lymphoid or epithelial organs of homozygous mice did not react with an anti-pan Tcrd mAb. Immunoprecipitation showed an absence of expression on the surface of thymocytes isolated from homozygous mutant embryos. |
| Mutations Made By | Peter Mombaerts, Max Planck Research Unit for Neurogenetics |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Tcrdtm1Mom related
- Hematological Research
- Immunological Defects
- Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
- Immunodeficiency
- Inflammation
- Inflammatory bowel disease
- T Cell Receptor Signaling Defects
- Research Tools
- Immunology, Inflammation and Autoimmunity Research
- T Cell Receptor Deficiency
- Immunology, Inflammation and Autoimmunity Research
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tcrdtm1Mom/Tcrdtm1Mom
either: (involves: 129P2/OlaHsd * BALB/cJ) or (involves: 129P2/OlaHsd * C57BL/6)
immune system phenotype
- abnormal gamma-delta T cell differentiation
- rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur (MGI Ref ID J:3865)
- absent gamma-delta T cells
- gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control (MGI Ref ID J:3865)
hematopoietic system phenotype
- abnormal gamma-delta T cell differentiation
- rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur (MGI Ref ID J:3865)
- absent gamma-delta T cells
- gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control (MGI Ref ID J:3865)
Genotype: Tcrdtm1Mom/Tcrdtm1Mom
B6;129P2-Tcrdtm1Mom/J
respiratory system phenotype
- abnormal respiratory system physiology
- ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation (MGI Ref ID J:125656)
Genotype: Tcrdtm1Mom/Tcrdtm1Mom
FVB.129P2-Tcrdtm1Mom
immune system phenotype
- dermatitis
- Background Sensitivity - no overt signs of spontaneous dermatitis on this background (MGI Ref ID J:75915)
- increased susceptibility to type IV hypersensitivity reaction
- Background Sensitivity - aggravated allergic contact dermatitis in response to DNFAB and irritant contact dermatitis (MGI Ref ID J:75915)
homeostasis/metabolism phenotype
- impaired skin barrier function
- transepidermal water loss as measured by skin surface impedance is increased under environmentally stressful conditions (MGI Ref ID J:106782)
integument phenotype
- abnormal skin condition
- Background Sensitivity - less extensive ear thickening (MGI Ref ID J:75915)
- dermatitis
- Background Sensitivity - no overt signs of spontaneous dermatitis on this background (MGI Ref ID J:75915)
- impaired skin barrier function
- transepidermal water loss as measured by skin surface impedance is increased under environmentally stressful conditions (MGI Ref ID J:106782)
Genotype: Tcrdtm1Mom/Tcrdtm1Mom
B6.129P2-Tcrdtm1Mom
immune system phenotype
- immune system phenotype
- Background Sensitivity - no evidence of spontaneous dermatitis, allergic or irritant contact dermatitis (MGI Ref ID J:75915)
cellular phenotype
- increased apoptosis
- apoptosis levels in the epidermis are 3 fold higher than in controls (MGI Ref ID J:94872)
integument phenotype
- integument phenotype
- Background Sensitivity - no skin abnormalities (MGI Ref ID J:75915)
References
- Itohara S; Mombaerts P; Lafaille J; Iacomini J; Nelson A; Clarke AR; Hooper ML; Farr A; Tonegawa S. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.. In: . . MGI: J:3865
Additional - Tcrdtm1Mom related
- Aifantis I; Bassing CH; Garbe AI; Sawai K; Alt FW; von Boehmer H. 2006. The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells.. In: . . MGI: J:124376
- Akitsu A; Ishigame H; Kakuta S; Chung SH; Ikeda S; Shimizu K; Kubo S; Liu Y; Umemura M; Matsuzaki G; Yoshikai Y; Saijo S; Iwakura Y. 2015. IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vgamma6(+)gammadelta T cells.. In: . . MGI: J:223006
- Alcon VL; Luther C; Balce D; Takei F. 2009. B-cell co-receptor CD72 is expressed on NK cells and inhibits IFN-gamma production but not cytotoxicity.. In: . . MGI: J:146477
- Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis.. In: . . MGI: J:138028
- Alugupalli KR; Akira S; Lien E; Leong JM. 2007. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses.. In: . . MGI: J:144277
- Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes.. In: . . MGI: J:125443
- Alugupalli KR; Leong JM; Woodland RT; Muramatsu M; Honjo T; Gerstein RM. 2004. B1b lymphocytes confer T cell-independent long-lasting immunity.. In: . . MGI: J:93752
- Ammirante M; Luo JL; Grivennikov S; Nedospasov S; Karin M. 2010. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer.. In: . . MGI: J:157973
- Anderson BE; McNiff JM; Matte C; Athanasiadis I; Shlomchik WD; Shlomchik MJ. 2004. Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease.. In: . . MGI: J:92701
- Andrew EM; Newton DJ; Dalton JE; Egan CE; Goodwin SJ; Tramonti D; Scott P; Carding SR. 2005. Delineation of the function of a major gamma delta T cell subset during infection.. In: . . MGI: J:105477
- Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx.. In: . . MGI: J:199531
- Arnold CN; Campbell DJ; Lipp M; Butcher EC. 2007. The germinal center response is impaired in the absence of T cell-expressed CXCR5.. In: . . MGI: J:117042
- Arwert EN; Lal R; Quist S; Rosewell I; van Rooijen N; Watt FM. 2010. Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate.. In: . . MGI: J:166606
- Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection.. In: . . MGI: J:119344
- Baban B; Chandler PR; Johnson BA 3rd; Huang L; Li M; Sharpe ML; Francisco LM; Sharpe AH; Blazar BR; Munn DH; Mellor AL. 2011. Physiologic control of IDO competence in splenic dendritic cells.. In: . . MGI: J:179269
- Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors.. In: . . MGI: J:98166
- Ballesteros-Tato A; Leon B; Lund FE; Randall TD. 2013. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza.. In: . . MGI: J:202249
- Barker TT; Lee PY; Kelly-Scumpia KM; Weinstein JS; Nacionales DC; Kumagai Y; Akira S; Croker BP; Sobel ES; Reeves WH; Satoh M. 2011. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane.. In: . . MGI: J:176270
- Barthold SW; Hodzic E; Tunev S; Feng S. 2006. Antibody-mediated disease remission in the mouse model of lyme borreliosis.. In: . . MGI: J:112329
- Beck BH; Kim H; O'Brien R; Jadus MR; Gillespie GY; Cloud GA; Hoa NT; Langford CP; Lopez RD; Harkins LE; Lamb LS Jr. 2015. Dynamics of Circulating gammadelta T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma.. In: . . MGI: J:235341
- Becker AM; Callahan DJ; Richner JM; Choi J; DiPersio JF; Diamond MS; Bhattacharya D. 2015. GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes following Bone Marrow Transplantation.. In: . . MGI: J:233534
- Bento AF; Marcon R; Dutra RC; Claudino RF; Cola M; Pereira Leite DF; Calixto JB. 2011. beta-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARgamma Pathway.. In: . . MGI: J:169691
- Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells.. In: . . MGI: J:113283
- Bian K; Zhong M; Harari Y; Lai M; Weisbrodt N; Murad F. 2005. Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis.. In: . . MGI: J:97167
- Bjordahl RL; Gapin L; Marrack P; Refaeli Y. 2012. iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma.. In: . . MGI: J:189824
- Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain.. In: . . MGI: J:133531
- Bonnet M; Huang F; Benoukraf T; Cabaud O; Verthuy C; Boucher A; Jaeger S; Ferrier P; Spicuglia S. 2009. Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model.. In: . . MGI: J:157494
- Bonorino C; Nardi NB; Zhang X; Wysocki LJ. 1998. Characteristics of the strong antibody response to mycobacterial Hsp70: a primary, T cell-dependent IgG response with no evidence of natural priming or gamma delta T cell involvement.. In: . . MGI: J:115026
- Borchers MT; Crosby J; Justice P; Farmer S; Hines E; Lee JJ; Lee NA. 2001. Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling.. In: . . MGI: J:132284
- Borchers MT; Wesselkamper SC; Eppert BL; Motz GT; Sartor MA; Tomlinson CR; Medvedovic M; Tichelaar JW. 2008. Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology.. In: . . MGI: J:139766
- Bortnick A; Chernova I; Quinn WJ 3rd; Mugnier M; Cancro MP; Allman D. 2012. Long-lived bone marrow plasma cells are induced early in response to T cell-independent or T cell-dependent antigens.. In: . . MGI: J:188747
- Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen.. In: . . MGI: J:87077
- Buchanan RM; Arulanandam BP; Metzger DW. 1998. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells.. In: . . MGI: J:115023
- Bunker JJ; Flynn TM; Koval JC; Shaw DG; Meisel M; McDonald BD; Ishizuka IE; Dent AL; Wilson PC; Jabri B; Antonopoulos DA; Bendelac A. 2015. Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.. In: . . MGI: J:233653
- Burns AM; Chong AS. 2011. Alloantibodies prevent the induction of transplantation tolerance by enhancing alloreactive T cell priming.. In: . . MGI: J:168797
- Byeseda SE; Burns AR; Dieffenbaugher S; Rumbaut RE; Smith CW; Li Z. 2009. ICAM-1 is necessary for epithelial recruitment of gammadelta T cells and efficient corneal wound healing.. In: . . MGI: J:150953
- Caccamo N; Sireci G; Meraviglia S; Dieli F; Ivanyi J; Salerno A. 2006. gammadelta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis.. In: . . MGI: J:118094
- Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50.. In: . . MGI: J:120419
- Cai Y; Shen X; Ding C; Qi C; Li K; Li X; Jala VR; Zhang HG; Wang T; Zheng J; Yan J. 2011. Pivotal Role of Dermal IL-17-Producing gammadelta T Cells in Skin Inflammation.. In: . . MGI: J:177652
- Cai Y; Xue F; Fleming C; Yang J; Ding C; Ma Y; Liu M; Zhang HG; Zheng J; Xiong N; Yan J. 2014. Differential developmental requirement and peripheral regulation for dermal Vgamma4 and Vgamma6T17 cells in health and inflammation.. In: . . MGI: J:225218
- Cao AT; Yao S; Gong B; Elson CO; Cong Y. 2012. Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis.. In: . . MGI: J:190633
- Cardona AE; Teale JM. 2002. gamma/delta T Cell-Deficient Mice Exhibit Reduced Disease Severity and Decreased Inflammatory Response in the Brain in Murine Neurocysticercosis.. In: . . MGI: J:78958
- Cariappa A; Mazo IB; Chase C; Shi HN; Liu H; Li Q; Rose H; Leung H; Cherayil BJ; Russell P; von Andrian U; Pillai S. 2005. Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes.. In: . . MGI: J:113277
- Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection.. In: . . MGI: J:109239
- Chan AJ; Alikhan MA; Odobasic D; Gan PY; Khouri MB; Steinmetz OM; Mansell AS; Kitching AR; Holdsworth SR; Summers SA. 2014. Innate IL-17A-Producing Leukocytes Promote Acute Kidney Injury via Inflammasome and Toll-Like Receptor Activation.. In: . . MGI: J:208397
- Chang JH; Hu H; Jin J; Puebla-Osorio N; Xiao Y; Gilbert BE; Brink R; Ullrich SE; Sun SC. 2014. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses.. In: . . MGI: J:208351
- Chappell CP; Draves KE; Giltiay NV; Clark EA. 2012. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses.. In: . . MGI: J:191423
- Chen Y; Chou K; Fuchs E; Havran WL; Boismenu R. 2002. Protection of the intestinal mucosa by intraepithelial gamma delta T cells.. In: . . MGI: J:125077
- Chennupati V; Worbs T; Liu X; Malinarich FH; Schmitz S; Haas JD; Malissen B; Forster R; Prinz I. 2010. Intra- and intercompartmental movement of gammadelta T cells: intestinal intraepithelial and peripheral gammadelta T cells represent exclusive nonoverlapping populations with distinct migration characteristics.. In: . . MGI: J:165201
- Cho JS; Pietras EM; Garcia NC; Ramos RI; Farzam DM; Monroe HR; Magorien JE; Blauvelt A; Kolls JK; Cheung AL; Cheng G; Modlin RL; Miller LS. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.. In: . . MGI: J:161481
- Chodaczek G; Papanna V; Zal MA; Zal T. 2012. Body-barrier surveillance by epidermal gammadelta TCRs.. In: . . MGI: J:181476
- Chung CS; Watkins L; Funches A; Lomas-Neira J; Cioffi WG; Ayala A. 2006. Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis.. In: . . MGI: J:144693
- Clark CA; Gupta HB; Sareddy G; Pandeswara S; Lao S; Yuan B; Drerup JM; Padron A; Conejo-Garcia J; Murthy K; Liu Y; Turk MJ; Thedieck K; Hurez V; Li R; Vadlamudi R; Curiel TJ. 2016. Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma.. In: . . MGI: J:237848
- Coffelt SB; Kersten K; Doornebal CW; Weiden J; Vrijland K; Hau CS; Verstegen NJ; Ciampricotti M; Hawinkels LJ; Jonkers J; de Visser KE. 2015. IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis.. In: . . MGI: J:224399
- Cong Y; Feng T; Fujihashi K; Schoeb TR; Elson CO. 2009. A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.. In: . . MGI: J:154759
- Conlon TM; Saeb-Parsy K; Cole JL; Motallebzadeh R; Qureshi MS; Rehakova S; Negus MC; Callaghan CJ; Bolton EM; Bradley JA; Pettigrew GJ. 2012. Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells.. In: . . MGI: J:181855
- Conti HR; Shen F; Nayyar N; Stocum E; Sun JN; Lindemann MJ; Ho AW; Hai JH; Yu JJ; Jung JW; Filler SG; Masso-Welch P; Edgerton M; Gaffen SL. 2009. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis.. In: . . MGI: J:146451
- Corthay A; Johansson A; Vestberg M; Holmdahl R. 1999. Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice.. In: . . MGI: J:56725
- Cox MA; Barnum SR; Bullard DC; Zajac AJ. 2013. ICAM-1-dependent tuning of memory CD8 T-cell responses following acute infection.. In: . . MGI: J:193714
- Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG.. In: . . MGI: J:125656
- Crosby JR; Shen HH; Borchers MT; Justice JP; Ansay T; Lee JJ; Lee NA. 2002. Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment.. In: . . MGI: J:107840
- Crowe CR; Chen K; Pociask DA; Alcorn JF; Krivich C; Enelow RI; Ross TM; Witztum JL; Kolls JK. 2009. Critical role of IL-17RA in immunopathology of influenza infection.. In: . . MGI: J:153826
- Cuda CM; Zeumer L; Sobel ES; Croker BP; Morel L. 2010. Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.. In: . . MGI: J:186900
- Dalessandri T; Crawford G; Hayes M; Castro Seoane R; Strid J. 2016. IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin.. In: . . MGI: J:240789
- Daley D; Zambirinis CP; Seifert L; Akkad N; Mohan N; Werba G; Barilla R; Torres-Hernandez A; Hundeyin M; Mani VR; Avanzi A; Tippens D; Narayanan R; Jang JE; Newman E; Pillarisetty VG; Dustin ML; Bar-Sagi D; Hajdu C; Miller G. 2016. gammadelta T Cells Support Pancreatic Oncogenesis by Restraining alphabeta T Cell Activation.. In: . . MGI: J:236387
- Do J; Visperas A; Freeman ML; Jang E; Kim S; Malissen B; Min B. 2016. gammadelta T cells support gut Ag-reactive colitogenic effector T-cell generation by enhancing Ag presentation by CD11b(+) DCs in the mesenteric LN.. In: . . MGI: J:234524
- Do JS; Min B. 2009. IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo.. In: . . MGI: J:150154
- Do JS; Valujskikh A; Vignali DA; Fairchild RL; Min B. 2012. Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo.. In: . . MGI: J:188517
- Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis.. In: . . MGI: J:93676
- Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice.. In: . . MGI: J:82106
- Dubin PJ; Martz A; Eisenstatt JR; Fox MD; Logar A; Kolls JK. 2012. Interleukin-23-Mediated Inflammation in Pseudomonas aeruginosa Pulmonary Infection.. In: . . MGI: J:178958
- Edelblum KL; Shen L; Weber CR; Marchiando AM; Clay BS; Wang Y; Prinz I; Malissen B; Sperling AI; Turner JR. 2012. Dynamic migration of gammadelta intraepithelial lymphocytes requires occludin.. In: . . MGI: J:183907
- Egan CE; Dalton JE; Andrew EM; Smith JE; Gubbels MJ; Striepen B; Carding SR. 2005. A requirement for the Vgamma1+ subset of peripheral gammadelta T cells in the control of the systemic growth of Toxoplasma gondii and infection-induced pathology.. In: . . MGI: J:122276
- Elhage R; Gourdy P; Brouchet L; Jawien J; Fouque MJ; Fievet C; Huc X; Barreira Y; Couloumiers JC; Arnal JF; Bayard F. 2004. Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice.. In: . . MGI: J:94976
- Emoto M; Nishimura H; Sakai T; Hiromatsu K; Gomi H; Itohara S; Yoshikai Y. 1995. Mice deficient in gamma delta T cells are resistant to lethal infection with Salmonella choleraesuis.. In: . . MGI: J:111169
- Endres R; Alimzhanov MB; Plitz T; Futterer A; Kosco-Vilbois MH; Nedospasov SA; Rajewsky K; Pfeffer K. 1999. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells.. In: . . MGI: J:119173
- Endt K; Stecher B; Chaffron S; Slack E; Tchitchek N; Benecke A; Van Maele L; Sirard JC; Mueller AJ; Heikenwalder M; Macpherson AJ; Strugnell R; von Mering C; Hardt WD. 2010. The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea.. In: . . MGI: J:167923
- Enzler T; Bonizzi G; Silverman GJ; Otero DC; Widhopf GF; Anzelon-Mills A; Rickert RC; Karin M. 2006. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease.. In: . . MGI: J:113556
- Felices M; Yin CC; Kosaka Y; Kang J; Berg LJ. 2009. Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo.. In: . . MGI: J:148531
- Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis.. In: . . MGI: J:87862
- Feng T; Qin H; Wang L; Benveniste EN; Elson CO; Cong Y. 2011. Th17 Cells Induce Colitis and Promote Th1 Cell Responses through IL-17 Induction of Innate IL-12 and IL-23 Production.. In: . . MGI: J:173176
- Ferlin WG; von der Weid T; Cottrez F; Ferrick DA; Coffman RL; Howard MC. 1998. The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAb.. In: . . MGI: J:46693
- Ferrero I; Mancini SJ; Grosjean F; Wilson A; Otten L; MacDonald HR. 2006. TCRgamma silencing during alphabeta T cell development depends upon pre-TCR-induced proliferation.. In: . . MGI: J:140526
- Figgett WA; Fairfax K; Vincent FB; Le Page MA; Katik I; Deliyanti D; Quah PS; Verma P; Grumont R; Gerondakis S; Hertzog P; O'Reilly LA; Strasser A; Mackay F. 2013. The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death.. In: . . MGI: J:208212
- Fischer K; Collins H; Taniguchi M; Kaufmann SH; Schaible UE. 2002. IL-4 and T cells are required for the generation of IgG1 isotype antibodies against cardiolipin.. In: . . MGI: J:126854
- Fleige H; Ravens S; Moschovakis GL; Bolter J; Willenzon S; Sutter G; Haussler S; Kalinke U; Prinz I; Forster R. 2014. IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs.. In: . . MGI: J:211677
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