JAX Mouse Strain Datasheet - 003448

CByJ.129P2(B6)-Tcrd^tm1Mom/Sz

Stock No:: 003448 |; BALB/cBy TCRdelta-

Cryo Recovery

Overview

Also Known As: BALB/cBy TCRdelta-, BALB/cByJ-Tcrd

These Tcrd knock-out mice exhibit deficiency of gamma delta T-cell receptor expression.

Genetic overview

Genetic Background	Generation

Tcrd^tm1Mom

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Tcrd	T cell receptor delta chain

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Research Applications

Hematological Research
Immunology, Inflammation and Autoimmunity Research
Research Tools

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Details

Detailed Description

Mice homozygous for this targeted mutation are viable and fertile. Gamma delta T-cell receptor expression is deficient in all adult lymphoid and epithelial organs. There is normal development of the alpha beta T-cell lineage. Patterns of CD4+CD8- and CD4-CD8+ alpha beta T-cells are apparently normal. Mice do not develop inflammatory bowel disease.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development

This targeted mutant strain was developed by Dr. Peter Mombaerts in the laboratory of Dr. Susumu Tonegawa at the Center for Cancer Research, Massachusetts Institute of Technology. A replacement targeting vector containing Pgk-neo was used which resulted in a 4 kb deletion encompassing most of the delta chain constant region coding sequences. This strain was generated in the laboratory of Dr. Leonard Shultz by backcrossing mice from B6.1292-Tcrd^tm1Mom/J to BALB/cByJ inbred mice for a minimum of 9 generations.

Selected References

Itohara S; Mombaerts P; Lafaille J; Iacomini J; Nelson A; Clarke AR; Hooper ML; Farr A; Tonegawa S. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell 72(3):337-48. PubMed: 8381716 MGI: J:3865

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Genetics

Tcrd^tm1Mom

Allele Symbol: Tcrd^tm1Mom

Allele Name	targeted mutation 1, Peter Mombaerts
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	C-delta-; TCRdelta KO; TCRdelta-; delta^-; delta⁰; gammadelta TCR^-
Gene Symbol and Name	Tcrd, T cell receptor delta chain
Gene Synonym(s)	Tcr delta; Tcrdelta
Strain of Origin	129P2/OlaHsd
Chromosome	14
Molecular Note	A PGK-neo cassette was used to disrupt the constant gene segment (designated C-delta). Flow cytometry showed that cells isolated from the lymphoid or epithelial organs of homozygous mice did not react with an anti-pan Tcrd mAb. Immunoprecipitation showed an absence of expression on the surface of thymocytes isolated from homozygous mutant embryos.
Mutations Made By	Peter Mombaerts, Max Planck Research Unit for Neurogenetics

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Tcrd^tm1Mom related

Hematological Research
- Immunological Defects
Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
- Immunodeficiency
- Inflammation
  - Inflammatory bowel disease
- T Cell Receptor Signaling Defects
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - T Cell Receptor Deficiency

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Tcrd^tm1Mom/Tcrd^tm1Mom
either: (involves: 129P2/OlaHsd * BALB/cJ) or (involves: 129P2/OlaHsd * C57BL/6)

immune system phenotype

abnormal gamma-delta T cell differentiation
- rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur

absent gamma-delta T cells
- gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control

hematopoietic system phenotype

abnormal gamma-delta T cell differentiation
- rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur

absent gamma-delta T cells
- gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control

Genotype: Tcrd^tm1Mom/Tcrd^tm1Mom
B6;129P2-Tcrd^tm1Mom/J

respiratory system phenotype

abnormal respiratory system physiology
- ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation

Genotype: Tcrd^tm1Mom/Tcrd^tm1Mom
FVB.129P2-Tcrd^tm1Mom

immune system phenotype

dermatitis
- Background Sensitivity - no overt signs of spontaneous dermatitis on this background

increased susceptibility to type IV hypersensitivity reaction
- Background Sensitivity - aggravated allergic contact dermatitis in response to DNFAB and irritant contact dermatitis

homeostasis/metabolism phenotype

impaired skin barrier function
- transepidermal water loss as measured by skin surface impedance is increased under environmentally stressful conditions

integument phenotype

abnormal skin condition
- Background Sensitivity - less extensive ear thickening

dermatitis
- Background Sensitivity - no overt signs of spontaneous dermatitis on this background

impaired skin barrier function
- transepidermal water loss as measured by skin surface impedance is increased under environmentally stressful conditions

Genotype: Tcrd^tm1Mom/Tcrd^tm1Mom
B6.129P2-Tcrd^tm1Mom

immune system phenotype

immune system phenotype
- Background Sensitivity - no evidence of spontaneous dermatitis, allergic or irritant contact dermatitis

cellular phenotype

increased apoptosis
- apoptosis levels in the epidermis are 3 fold higher than in controls

integument phenotype

integument phenotype
- Background Sensitivity - no skin abnormalities

References

Itohara S; Mombaerts P; Lafaille J; Iacomini J; Nelson A; Clarke AR; Hooper ML; Farr A; Tonegawa S. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell 72(3):337-48. PubMed: 8381716 MGI: J:3865

Additional - Tcrd^tm1Mom related

Aifantis I; Bassing CH; Garbe AI; Sawai K; Alt FW; von Boehmer H. 2006. The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells. J Exp Med 203(6):1543-50. PubMed: 16754716 MGI: J:124376
Akitsu A; Ishigame H; Kakuta S; Chung SH; Ikeda S; Shimizu K; Kubo S; Liu Y; Umemura M; Matsuzaki G; Yoshikai Y; Saijo S; Iwakura Y. 2015. IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vgamma6(+)gammadelta T cells. Nat Commun 6:7464. PubMed: 26108163 MGI: J:223006
Alcon VL; Luther C; Balce D; Takei F. 2009. B-cell co-receptor CD72 is expressed on NK cells and inhibits IFN-gamma production but not cytotoxicity. Eur J Immunol 39(3):826-32. PubMed: 19197938 MGI: J:146477
Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. J Immunol 177(3):1763-71. PubMed: 16849486 MGI: J:138028
Alugupalli KR; Akira S; Lien E; Leong JM. 2007. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol 178(6):3740-9. PubMed: 17339472 MGI: J:144277
Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. PubMed: 12646649 MGI: J:125443
Alugupalli KR; Leong JM; Woodland RT; Muramatsu M; Honjo T; Gerstein RM. 2004. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21(3):379-90. PubMed: 15357949 MGI: J:93752
Ammirante M; Luo JL; Grivennikov S; Nedospasov S; Karin M. 2010. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464(7286):302-5. PubMed: 20220849 MGI: J:157973
Anderson BE; McNiff JM; Matte C; Athanasiadis I; Shlomchik WD; Shlomchik MJ. 2004. Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease. Blood 104(5):1565-73. PubMed: 15150080 MGI: J:92701
Andrew EM; Newton DJ; Dalton JE; Egan CE; Goodwin SJ; Tramonti D; Scott P; Carding SR. 2005. Delineation of the function of a major gamma delta T cell subset during infection. J Immunol 175(3):1741-50. PubMed: 16034115 MGI: J:105477
Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx. Infect Immun 81(6):2070-5. PubMed: 23529621 MGI: J:199531
Arnold CN; Campbell DJ; Lipp M; Butcher EC. 2007. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 37(1):100-9. PubMed: 17171760 MGI: J:117042
Arwert EN; Lal R; Quist S; Rosewell I; van Rooijen N; Watt FM. 2010. Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate. Proc Natl Acad Sci U S A 107(46):19903-8. PubMed: 21041641 MGI: J:166606
Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. PubMed: 16272283 MGI: J:119344
Baban B; Chandler PR; Johnson BA 3rd; Huang L; Li M; Sharpe ML; Francisco LM; Sharpe AH; Blazar BR; Munn DH; Mellor AL. 2011. Physiologic control of IDO competence in splenic dendritic cells. J Immunol 187(5):2329-35. PubMed: 21813777 MGI: J:179269
Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. PubMed: 15814683 MGI: J:98166
Ballesteros-Tato A; Leon B; Lund FE; Randall TD. 2013. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. J Exp Med 210(8):1591-601. PubMed: 23835849 MGI: J:202249
Barker TT; Lee PY; Kelly-Scumpia KM; Weinstein JS; Nacionales DC; Kumagai Y; Akira S; Croker BP; Sobel ES; Reeves WH; Satoh M. 2011. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. Lab Invest 91(10):1540-50. PubMed: 21808234 MGI: J:176270
Barthold SW; Hodzic E; Tunev S; Feng S. 2006. Antibody-mediated disease remission in the mouse model of lyme borreliosis. Infect Immun 74(8):4817-25. PubMed: 16861670 MGI: J:112329
Beck BH; Kim H; O'Brien R; Jadus MR; Gillespie GY; Cloud GA; Hoa NT; Langford CP; Lopez RD; Harkins LE; Lamb LS Jr. 2015. Dynamics of Circulating gammadelta T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma. PLoS One 10(5):e0122387. PubMed: 25955158 MGI: J:235341
Becker AM; Callahan DJ; Richner JM; Choi J; DiPersio JF; Diamond MS; Bhattacharya D. 2015. GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes following Bone Marrow Transplantation. PLoS One 10(7):e0133854. PubMed: 26197390 MGI: J:233534
Bento AF; Marcon R; Dutra RC; Claudino RF; Cola M; Pereira Leite DF; Calixto JB. 2011. beta-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARgamma Pathway. Am J Pathol 178(3):1153-66. PubMed: 21356367 MGI: J:169691
Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. PubMed: 16286018 MGI: J:113283
Bian K; Zhong M; Harari Y; Lai M; Weisbrodt N; Murad F. 2005. Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Proc Natl Acad Sci U S A 102(11):3936-41. PubMed: 15741272 MGI: J:97167
Bjordahl RL; Gapin L; Marrack P; Refaeli Y. 2012. iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma. PLoS One 7(8):e42635. PubMed: 22880059 MGI: J:189824
Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. PubMed: 18227174 MGI: J:133531
Bonnet M; Huang F; Benoukraf T; Cabaud O; Verthuy C; Boucher A; Jaeger S; Ferrier P; Spicuglia S. 2009. Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model. J Immunol 183(12):7939-48. PubMed: 19923469 MGI: J:157494
Bonorino C; Nardi NB; Zhang X; Wysocki LJ. 1998. Characteristics of the strong antibody response to mycobacterial Hsp70: a primary, T cell-dependent IgG response with no evidence of natural priming or gamma delta T cell involvement. J Immunol 161(10):5210-6. PubMed: 9820492 MGI: J:115026
Borchers MT; Crosby J; Justice P; Farmer S; Hines E; Lee JJ; Lee NA. 2001. Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling. Am J Physiol Lung Cell Mol Physiol 281(3):L653-9. PubMed: 11504693 MGI: J:132284
Borchers MT; Wesselkamper SC; Eppert BL; Motz GT; Sartor MA; Tomlinson CR; Medvedovic M; Tichelaar JW. 2008. Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology. Toxicol Sci 105(1):188-99. PubMed: 18515264 MGI: J:139766
Bortnick A; Chernova I; Quinn WJ 3rd; Mugnier M; Cancro MP; Allman D. 2012. Long-lived bone marrow plasma cells are induced early in response to T cell-independent or T cell-dependent antigens. J Immunol 188(11):5389-96. PubMed: 22529295 MGI: J:188747
Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. PubMed: 14688352 MGI: J:87077
Buchanan RM; Arulanandam BP; Metzger DW. 1998. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells. J Immunol 161(10):5525-33. PubMed: 9820529 MGI: J:115023
Bunker JJ; Flynn TM; Koval JC; Shaw DG; Meisel M; McDonald BD; Ishizuka IE; Dent AL; Wilson PC; Jabri B; Antonopoulos DA; Bendelac A. 2015. Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A. Immunity 43(3):541-53. PubMed: 26320660 MGI: J:233653
Burns AM; Chong AS. 2011. Alloantibodies prevent the induction of transplantation tolerance by enhancing alloreactive T cell priming. J Immunol 186(1):214-21. PubMed: 21135169 MGI: J:168797
Byeseda SE; Burns AR; Dieffenbaugher S; Rumbaut RE; Smith CW; Li Z. 2009. ICAM-1 is necessary for epithelial recruitment of gammadelta T cells and efficient corneal wound healing. Am J Pathol 175(2):571-9. PubMed: 19608878 MGI: J:150953
Caccamo N; Sireci G; Meraviglia S; Dieli F; Ivanyi J; Salerno A. 2006. gammadelta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis. Eur J Immunol 36(10):2681-90. PubMed: 16981183 MGI: J:118094
Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 165(4):1790-8. PubMed: 10925256 MGI: J:120419
Cai Y; Shen X; Ding C; Qi C; Li K; Li X; Jala VR; Zhang HG; Wang T; Zheng J; Yan J. 2011. Pivotal Role of Dermal IL-17-Producing gammadelta T Cells in Skin Inflammation. Immunity 35(4):596-610. PubMed: 21982596 MGI: J:177652
Cai Y; Xue F; Fleming C; Yang J; Ding C; Ma Y; Liu M; Zhang HG; Zheng J; Xiong N; Yan J. 2014. Differential developmental requirement and peripheral regulation for dermal Vgamma4 and Vgamma6T17 cells in health and inflammation. Nat Commun 5:3986. PubMed: 24909159 MGI: J:225218
Cao AT; Yao S; Gong B; Elson CO; Cong Y. 2012. Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis. J Immunol 189(9):4666-73. PubMed: 22993206 MGI: J:190633
Cardona AE; Teale JM. 2002. gamma/delta T Cell-Deficient Mice Exhibit Reduced Disease Severity and Decreased Inflammatory Response in the Brain in Murine Neurocysticercosis. J Immunol 169(6):3163-71. PubMed: 12218134 MGI: J:78958
Cariappa A; Mazo IB; Chase C; Shi HN; Liu H; Li Q; Rose H; Leung H; Cherayil BJ; Russell P; von Andrian U; Pillai S. 2005. Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity 23(4):397-407. PubMed: 16226505 MGI: J:113277
Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. PubMed: 16714546 MGI: J:109239
Chan AJ; Alikhan MA; Odobasic D; Gan PY; Khouri MB; Steinmetz OM; Mansell AS; Kitching AR; Holdsworth SR; Summers SA. 2014. Innate IL-17A-Producing Leukocytes Promote Acute Kidney Injury via Inflammasome and Toll-Like Receptor Activation. Am J Pathol 184(5):1411-8. PubMed: 24631024 MGI: J:208397
Chang JH; Hu H; Jin J; Puebla-Osorio N; Xiao Y; Gilbert BE; Brink R; Ullrich SE; Sun SC. 2014. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. J Exp Med 211(1):137-51. PubMed: 24378539 MGI: J:208351
Chappell CP; Draves KE; Giltiay NV; Clark EA. 2012. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J Exp Med 209(10):1825-40. PubMed: 22966002 MGI: J:191423
Chen Y; Chou K; Fuchs E; Havran WL; Boismenu R. 2002. Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A 99(22):14338-43. PubMed: 12376619 MGI: J:125077
Chennupati V; Worbs T; Liu X; Malinarich FH; Schmitz S; Haas JD; Malissen B; Forster R; Prinz I. 2010. Intra- and intercompartmental movement of gammadelta T cells: intestinal intraepithelial and peripheral gammadelta T cells represent exclusive nonoverlapping populations with distinct migration characteristics. J Immunol 185(9):5160-8. PubMed: 20870939 MGI: J:165201
Cho JS; Pietras EM; Garcia NC; Ramos RI; Farzam DM; Monroe HR; Magorien JE; Blauvelt A; Kolls JK; Cheung AL; Cheng G; Modlin RL; Miller LS. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest 120(5):1762-73. PubMed: 20364087 MGI: J:161481
Chodaczek G; Papanna V; Zal MA; Zal T. 2012. Body-barrier surveillance by epidermal gammadelta TCRs. Nat Immunol 13(3):272-82. PubMed: 22327568 MGI: J:181476
Chung CS; Watkins L; Funches A; Lomas-Neira J; Cioffi WG; Ayala A. 2006. Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis. Am J Physiol Regul Integr Comp Physiol 291(5):R1338-43. PubMed: 16793935 MGI: J:144693
Clark CA; Gupta HB; Sareddy G; Pandeswara S; Lao S; Yuan B; Drerup JM; Padron A; Conejo-Garcia J; Murthy K; Liu Y; Turk MJ; Thedieck K; Hurez V; Li R; Vadlamudi R; Curiel TJ. 2016. Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma. Cancer Res 76(23):6964-6974. PubMed: 27671674 MGI: J:237848
Coffelt SB; Kersten K; Doornebal CW; Weiden J; Vrijland K; Hau CS; Verstegen NJ; Ciampricotti M; Hawinkels LJ; Jonkers J; de Visser KE. 2015. IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis. Nature 522(7556):345-8. PubMed: 25822788 MGI: J:224399
Cong Y; Feng T; Fujihashi K; Schoeb TR; Elson CO. 2009. A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A 106(46):19256-61. PubMed: 19889972 MGI: J:154759
Conlon TM; Saeb-Parsy K; Cole JL; Motallebzadeh R; Qureshi MS; Rehakova S; Negus MC; Callaghan CJ; Bolton EM; Bradley JA; Pettigrew GJ. 2012. Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells. J Immunol 188(6):2643-52. PubMed: 22323543 MGI: J:181855
Conti HR; Shen F; Nayyar N; Stocum E; Sun JN; Lindemann MJ; Ho AW; Hai JH; Yu JJ; Jung JW; Filler SG; Masso-Welch P; Edgerton M; Gaffen SL. 2009. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med 206(2):299-311. PubMed: 19204111 MGI: J:146451
Corthay A; Johansson A; Vestberg M; Holmdahl R. 1999. Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice. Int Immunol 11(7):1065-73. PubMed: 10383939 MGI: J:56725
Cox MA; Barnum SR; Bullard DC; Zajac AJ. 2013. ICAM-1-dependent tuning of memory CD8 T-cell responses following acute infection. Proc Natl Acad Sci U S A 110(4):1416-21. PubMed: 23297203 MGI: J:193714
Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4. PubMed: 11937563 MGI: J:125656
Crosby JR; Shen HH; Borchers MT; Justice JP; Ansay T; Lee JJ; Lee NA. 2002. Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment. Am J Physiol Lung Cell Mol Physiol 282(1):L99-108. PubMed: 11741821 MGI: J:107840
Crowe CR; Chen K; Pociask DA; Alcorn JF; Krivich C; Enelow RI; Ross TM; Witztum JL; Kolls JK. 2009. Critical role of IL-17RA in immunopathology of influenza infection. J Immunol 183(8):5301-10. PubMed: 19783685 MGI: J:153826
Cuda CM; Zeumer L; Sobel ES; Croker BP; Morel L. 2010. Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells. Genes Immun 11(7):542-53. PubMed: 20445563 MGI: J:186900
Dalessandri T; Crawford G; Hayes M; Castro Seoane R; Strid J. 2016. IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin. Nat Commun 7:12080. PubMed: 27357235 MGI: J:240789
Daley D; Zambirinis CP; Seifert L; Akkad N; Mohan N; Werba G; Barilla R; Torres-Hernandez A; Hundeyin M; Mani VR; Avanzi A; Tippens D; Narayanan R; Jang JE; Newman E; Pillarisetty VG; Dustin ML; Bar-Sagi D; Hajdu C; Miller G. 2016. gammadelta T Cells Support Pancreatic Oncogenesis by Restraining alphabeta T Cell Activation. Cell 166(6):1485-1499.e15. PubMed: 27569912 MGI: J:236387
Do J; Visperas A; Freeman ML; Jang E; Kim S; Malissen B; Min B. 2016. gammadelta T cells support gut Ag-reactive colitogenic effector T-cell generation by enhancing Ag presentation by CD11b(+) DCs in the mesenteric LN. Eur J Immunol 46(2):340-6. PubMed: 26549797 MGI: J:234524
Do JS; Min B. 2009. IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo. Blood 113(25):6361-71. PubMed: 19380870 MGI: J:150154
Do JS; Valujskikh A; Vignali DA; Fairchild RL; Min B. 2012. Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo. Proc Natl Acad Sci U S A 109(31):12698-703. PubMed: 22802622 MGI: J:188517
Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. PubMed: 15466391 MGI: J:93676
Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology 124(3):672-82. PubMed: 12612906 MGI: J:82106
Dubin PJ; Martz A; Eisenstatt JR; Fox MD; Logar A; Kolls JK. 2012. Interleukin-23-Mediated Inflammation in Pseudomonas aeruginosa Pulmonary Infection. Infect Immun 80(1):398-409. PubMed: 22025517 MGI: J:178958
Edelblum KL; Shen L; Weber CR; Marchiando AM; Clay BS; Wang Y; Prinz I; Malissen B; Sperling AI; Turner JR. 2012. Dynamic migration of gammadelta intraepithelial lymphocytes requires occludin. Proc Natl Acad Sci U S A 109(18):7097-102. PubMed: 22511722 MGI: J:183907
Egan CE; Dalton JE; Andrew EM; Smith JE; Gubbels MJ; Striepen B; Carding SR. 2005. A requirement for the Vgamma1+ subset of peripheral gammadelta T cells in the control of the systemic growth of Toxoplasma gondii and infection-induced pathology. J Immunol 175(12):8191-9. PubMed: 16339558 MGI: J:122276
Elhage R; Gourdy P; Brouchet L; Jawien J; Fouque MJ; Fievet C; Huc X; Barreira Y; Couloumiers JC; Arnal JF; Bayard F. 2004. Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice. Am J Pathol 165(6):2013-8. PubMed: 15579444 MGI: J:94976
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Also Known As: BALB/cBy TCRdelta-, BALB/cByJ-Tcrd

Genetic overview

Research Applications

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Development

Selected References

Tcrdtm1Mom

Allele Symbol: Tcrdtm1Mom

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Tcrdtm1Mom related

Mammalian Phenotype Terms by Genotype

Genotype: Tcrdtm1Mom/Tcrdtm1Momeither: (involves: 129P2/OlaHsd * BALB/cJ) or (involves: 129P2/OlaHsd * C57BL/6)

immune system phenotype

hematopoietic system phenotype

Genotype: Tcrdtm1Mom/Tcrdtm1MomB6;129P2-Tcrdtm1Mom/J

respiratory system phenotype

Genotype: Tcrdtm1Mom/Tcrdtm1MomFVB.129P2-Tcrdtm1Mom

immune system phenotype

homeostasis/metabolism phenotype

integument phenotype

Genotype: Tcrdtm1Mom/Tcrdtm1MomB6.129P2-Tcrdtm1Mom

immune system phenotype

cellular phenotype

integument phenotype

References

Additional - Tcrdtm1Mom related

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Citation

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Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Progeny testing is not required

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Tcrd^tm1Mom

Allele Symbol: Tcrd^tm1Mom

Genotype: Tcrd^tm1Mom related

Genotype: Tcrd^tm1Mom/Tcrd^tm1Mom
either: (involves: 129P2/OlaHsd * BALB/cJ) or (involves: 129P2/OlaHsd * C57BL/6)

Genotype: Tcrd^tm1Mom/Tcrd^tm1Mom
B6;129P2-Tcrd^tm1Mom/J

Genotype: Tcrd^tm1Mom/Tcrd^tm1Mom
FVB.129P2-Tcrd^tm1Mom

Genotype: Tcrd^tm1Mom/Tcrd^tm1Mom
B6.129P2-Tcrd^tm1Mom

Additional - Tcrd^tm1Mom related