JAX Mouse Strain Datasheet - 003447

CBy.129P2(B6)-Tcrb^tm1Mom/SzJ

Stock No:: 003447

Not Available at JAX

Overview

Also Known As: BALB-Tcrb

This strain has been discontinued. Please search JAX^® Mice Database for other strains with the Tcrb^tm1Mom allele.

This targeted mutation of the T cell receptor beta chain gene is severely deficient in thymocytes and CD4⁺ CD8⁺ cells and may be useful in studies involving T cell receptors.

Genetic overview

Genetic Background	Generation
001026 BALB/cByJ

Tcrb^tm1Mom

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Tcrb	T cell receptor beta chain

View Genetics

Research Applications

Hematological Research
Immunology, Inflammation and Autoimmunity Research

View All Research Applications

Details

Detailed Description

Mice homozygous for the Tcrb^tm1Mom targeted mutation are viable and fertile. Mice are deficient in alpha beta T-cell receptor. The total number of cells in the thymus is ~8% that of wild-type; CD4⁺CD8⁺ cells ~6% of wild-type. The proportion of CD4-CD8- (IL2 receptor positive) cells increases to about 50% of the total cell number. Alpha beta thymocyte differentiation is blocked at an earlier stage than the Tcra^tm1Mom strain. There is normal differentiation of gamma delta thymocytes. Mice may develop inflammatory bowel disease beginning at ~4-6 months of age.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development

This targeted mutant strain was developed by Dr. Peter Mombaerts in the laboratory of Dr. Susumu Tonegawa at the Center for Cancer Research, Massachusetts Institute of Technology. A targeting replacement vector was used which resulted in a 15-kb deletion encompassing the Tcrb locus from J-beta-1.3 to downstream of C-beta-2. The mutant contains the Pgk-neo gene in reverse transcriptional orientation. The 129-derived E14 ES cell line was used. This strain was generated in the laboratory of Dr. Leonard Shultz by backcrossing mice from B6.129P2-Tcrb^tm1Mom/J (002118) to BALB/cByJ inbred mice for a minimum of 10 generations.

Control Suggestions

001026 BALB/cByJ

Additional Information

Considerations for Choosing Controls

Genetics

Tcrb^tm1Mom

Allele Symbol: Tcrb^tm1Mom

Allele Name	targeted mutation 1, Peter Mombaerts
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	CBeta^-; TCR-Cbeta-; TCRb^-; TCRbeta-; beta-
Gene Symbol and Name	Tcrb, T cell receptor beta chain
Gene Synonym(s)	TCRbeta; Tib; Tib
Strain of Origin	129P2/OlaHsd
Chromosome	6
Molecular Note	15kb of sequence was replaced with a PGK-neo cassette. The deletion included one of the two D gene segments, ten of the twelve J gene segments, and both constant gene segments.
Mutations Made By	Peter Mombaerts, Max Planck Research Unit for Neurogenetics

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Tcrb^tm1Mom related

Hematological Research
- Immunological Defects
Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
- Immunodeficiency
- Inflammation
  - Inflammatory bowel disease
- T Cell Receptor Signaling Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Tcrb^tm1Mom/Tcrb^tm1Mom
B6;129P2-Tcrb^tm1Mom/J

respiratory system phenotype

abnormal respiratory system physiology
- ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation

Genotype: Tcrb^tm1Mom/Tcrb^tm1Mom
involves: 129P2/OlaHsd * BALB/c

immune system phenotype

arrested T cell differentiation
- most T cells in the thymus do no progress to the double negative stage

colitis
- mild colitis-like disease occurs in mice over one year in age

decreased CD4-positive, alpha beta T cell number
- very few T cells are found in the thymus or periphery

decreased CD8-positive, alpha-beta T cell number
- very few CD8 T cells are found in the thymus or periphery

decreased double-positive T cell number
- 94% reduction in number of double positive cells

thymus hypoplasia
- 92% reduction in number of total thymocytes

digestive/alimentary phenotype

colitis
- mild colitis-like disease occurs in mice over one year in age

hematopoietic system phenotype

arrested T cell differentiation
- most T cells in the thymus do no progress to the double negative stage

decreased CD4-positive, alpha beta T cell number
- very few T cells are found in the thymus or periphery

decreased CD8-positive, alpha-beta T cell number
- very few CD8 T cells are found in the thymus or periphery

decreased double-positive T cell number
- 94% reduction in number of double positive cells

thymus hypoplasia
- 92% reduction in number of total thymocytes

endocrine/exocrine gland phenotype

thymus hypoplasia
- 92% reduction in number of total thymocytes

References

Additional - Tcrb^tm1Mom related

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Dieude M; Striegl H; Tyznik AJ; Wang J; Behar SM; Piccirillo CA; Levine JS; Zajonc DM; Rauch J. 2011. Cardiolipin binds to CD1d and stimulates CD1d-restricted gammadelta T cells in the normal murine repertoire. J Immunol 186(8):4771-81. PubMed: 21389252 MGI: J:172464
Do J; Visperas A; Freeman ML; Jang E; Kim S; Malissen B; Min B. 2016. gammadelta T cells support gut Ag-reactive colitogenic effector T-cell generation by enhancing Ag presentation by CD11b(+) DCs in the mesenteric LN. Eur J Immunol 46(2):340-6. PubMed: 26549797 MGI: J:234524
Do JS; Min B. 2009. Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo. Proc Natl Acad Sci U S A 106(48):20394-8. PubMed: 19920180 MGI: J:155564
Do JS; Min B. 2009. IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo. Blood 113(25):6361-71. PubMed: 19380870 MGI: J:150154
Do JS; Valujskikh A; Vignali DA; Fairchild RL; Min B. 2012. Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo. Proc Natl Acad Sci U S A 109(31):12698-703. PubMed: 22802622 MGI: J:188517
Do JS; Visperas A; Dong C; Baldwin WM 3rd; Min B. 2011. Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ gammadelta T cells. J Immunol 186(8):4546-50. PubMed: 21402889 MGI: J:172525
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