JAX Mouse Strain Datasheet - 003314

FVB/N-Tg(EIIa-cre)C5379Lmgd/J

Stock No:: 003314 |; E2a-Cre

Transgenic

Cryo Recovery

Overview

Also Known As: E2a-Cre

This line carries a Cre transgene under the control of the adenovirus EIIa promoter that targets expression of Cre recombinase to the early mouse embryo. Cre-mediated recombination occurs in a wide range of tissues, including the germ cells that transmit the genetic alteration to progeny.

Donating Investigator

Dr. Heiner Westphal, National Institutes of Health

Genetic overview

Genetic Background	Generation

Tg(EIIa-cre)C5379Lmgd

Allele Type
Transgenic (Recombinase-expressing)

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Research Applications

Research Tools

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

This line carries a Cre transgene under the control of the adenovirus EIIa promoter that targets expression of Cre recombinase to the early mouse embryo. Cre expression is thought to occur prior to implantation in the uterine wall. A mosaic pattern of expression is commonly observed. Cre-mediated recombination occurs in a wide range of tissues, including the germ cells that transmit the genetic alteration to progeny.

View cre expression characterization.

Development

The EIIa-Cre plasmid was constructed by replacing the human cytomegalovirus promoter in pBS185 with the adenovirus EIIa promoter from pEII-lacZ. cre activity present in zygotes of the EIIa-cre genotype was measured as follows. EIIa-cre/EIIa-cre homozygous animals were mated with +/alphaA-loxP-STOP-loxP-TAg heterozygous animals and the presence of lens tumors in double transgenic progeny, indicative of cre-mediated excision of STOP sequences and a concomitant activation of SV40 TAg, was scored. The strain originated on an FVB/N background. The strain is homozygous for the transgene. Analysis at The Jackson Laboratory Repository suggests that the transgene has integrated into a region on chromosome 6 between 18 Mbp and 95 Mbp (see additional information below).

Some FVB.EIIa-Cre mice from this colony were used for marker-assisted backcrossing onto other inbred backgrounds. During that process, single nucleotide polymorphism (SNP) testing revealed a region on chromosome 6 between 18 Mbp and 95 Mbp that remained FVB allele-type in EIIa-Cre transgenic mice. These data suggest the transgene has integrated into this region of chromosome 6.

Expression Data

Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	widespread expression (including germline); mosaic pattern commonly observed

Control Suggestions

001800 FVB/NJ

Additional Information

Considerations for Choosing Controls

Selected References

Lakso M; Pichel JG; Gorman JR; Sauer B; Okamoto Y; Lee E; Alt FW; Westphal H. 1996. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 93(12):5860-5. PubMed: 8650183 MGI: J:70555

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Genetics

Tg(EIIa-cre)C5379Lmgd

Allele Symbol: Tg(EIIa-cre)C5379Lmgd

Allele Name	transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal
Allele Type	Transgenic (Recombinase-expressing)
Allele Synonym(s)	E2a-Cre; EII-cre; EIIa Cre^tg; EIIa-cre; EIIaCre; EIIaCre deleter; Ela-Cre; Ella:Cre; TgN(EIIa-Cre)C5379Lmgd
Gene Symbol and Name	Tg(EIIa-cre)C5379Lmgd, transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal
Gene Synonym(s)	E2a-Cre; EII-cre; EIIa Cre^tg; EIIa-cre; EIIaCre; EIIaCre deleter; Ela-Cre; TgN(EIIa-Cre)C5379Lmgd
Promoter	Ella, adenovirus, adenovirus
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	widespread expression (including germline); mosaic pattern commonly observed
Strain of Origin	FVB/N
Chromosome	UN
Molecular Note	The adenovirus EIIa promoter directs expression of Cre recombinase in preimplantation mouse embryos. This transgene expresses Cre recombinase in nearly all tissues.
Mutations Made By	Dr. Heiner Westphal, National Institutes of Health

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- Cre-lox System
  - Cre Recombinase Expression
  - Cre Recombinase Expression: Germline/Embryonic Expression
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

Genotype: cre related

Research Tools
- Cre-lox System
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

References

Lakso M; Pichel JG; Gorman JR; Sauer B; Okamoto Y; Lee E; Alt FW; Westphal H. 1996. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 93(12):5860-5. PubMed: 8650183 MGI: J:70555

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Also Known As: E2a-Cre

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Tg(EIIa-cre)C5379Lmgd

Allele Symbol: Tg(EIIa-cre)C5379Lmgd

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This mouse can be used to support research in many areas including:

Genotype: cre related

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