This strain is congenic for a 19 cM segment of Chr 17 that includes the major histocompatibility complex, H2, and the insulin dependent diabetes susceptibility locus Idd1. A significant number of mice of this strain exhibit periinsulitis and more extensive mononuclear cell infiltrates in the pancreata. Male and female B6.NOD-(D17Mit21-D17Mit10) mice exhibited similar incidence of pancreatic infiltration.
|Allele Type||Gene Symbol||Gene Name|
|Not Applicable||H2||histocompatibility-2, MHC|
|Allele Type||Gene Symbol||Gene Name|
|QTL||Idd1||insulin dependent diabetes susceptibility 1|
|Marker Symbol||Marker Name|
|D17Mit10||DNA segment, Chr 17, Massachusetts Institute of Technology 10|
|D17Mit21||DNA segment, Chr 17, Massachusetts Institute of Technology 21|
This strain is congenic for a 19 cM segment of Chr 17 extending from D17Mit21 through D17Mit10 that includes the major histocompatibility complex, H2, and the insulin dependent diabetes susceptibility locus Idd1. The name given this segment in the primary reference is c17. Upon histologic examination of the pancreas, a significantly higher percentage of B6.NOD-(D17Mit21-D17Mit10) congenic mice than of C57BL/6J control mice were found to exhibit periinsulitis, and more extensive mononuclear cell infiltrates were observed in the pancreata of these mice. The pancreatic infiltrates were not associated specifically with the islets. Insulitis (intraislet infiltration) was extremely rare, and no more than one affected islet was observed in a single animal, even in cases where extensive perivascular/periductal infiltrates existed. Male and female B6.NOD-(D17Mit21-D17Mit10) mice exhibited similar incidence of pancreatic infiltration; in contrast, female NOD mice are more susceptible than males to both insulitis and diabetes.
Genomic segments found in earlier linkage studies to include diabetogenic loci were transferred from NOD/Uf to C57BL/6 by six successive backcrosses (to N7). Sibs of each lineage were then intercrossed to generate homozygotes for each segment. Microsatellite analysis was used to type mice for loci in the regions of interest.
|Allele Name||g7 variant|
|Allele Type||Not Applicable|
|Gene Symbol and Name||H2, histocompatibility-2, MHC|
|Gene Synonym(s)||H-2; H-2; MHC-II|
|Strain of Origin||Not Applicable|
|General Note||The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2g7|
|Gene Symbol and Name||Idd1, insulin dependent diabetes susceptibility 1|
|Gene Synonym(s)||Idd-1; Idd-1|
|Strain of Origin||NOD/Uf|
|General Note||NOD is homozygous for recessive alleles for susceptibility at all three loci, Idd1s, Idd2s, and Idd3s. The dominant alleles for non-susceptibility to IDD, Idd1r, etc., occur in the NON strain. Homozygosity for the recessive alleles at all three loci is necessary for the development of IDD.The Idd1 locus is linked to the major histocompatibility locus on Chr 17, but Idd2 is on Chr 9 (1) and Idd3 is on Chr 3 (J:8783, J:3351). |
This locus is also linked to peripheral CD4 lymphocytosis.
|Molecular Note||This allele confers increased periinsulitis and increased CD4 lymphocytosis compared to C57BL/6.|
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided,
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