STOCK Tg(tetL)1Bjd/J

Stock number: 003275
Research areas: Research Tools

Description

These mice carry a transgene containing the luciferase gene coupled to a tetracycline-responsive promoter element (TRE).

Detailed description

STOCK Tg(tetL)1Bjd/J transgenic mice are viable, fertile, and do not display an overt phenotype. These transgenic mice carry the luciferase gene coupled to a tetracycline-responsive promoter element (TRE). When mated to a strain expressing the tetracycline-controlled activator proteins tTA or rtTA coupled to a tissue-specific promoter, luciferase will be expressed in the appropriate tissue in a tetracycline-inducible fashion.

Development

The strain originated on an NMRI (outbred) background and remains on this background.

Allele

Symbol: Tg(tetL)1Bjd
Name: transgene insertion 1, Hermann Bujard
MGI accession ID: MGI:3056776
Generation method: Transgenic
Attributes: Reporter
Marker symbol: Tg(tetL)1Bjd
Marker name: transgene insertion 1, Hermann Bujard
Chromosome: UN
Strain of origin: NMRI
Expressed genes: luc,luciferase,firefly
Site of expression: When mated to a strain carrying the tTA gene coupled to a tissue specific promoter, luciferase will be expressed in the appropriate tissue.
Molecular note: The transgene carries the luciferase gene coupled to a tetracycline-responsive promoter element (TRE).
General note: Transgenic mice are viable, fertile, and do not display an overt phenotype.

In conjunction with a second transgene expressing the tetracycline-controlled activator proteins tTA or rtTA coupled to a tissue-specific promoter (examples include: Tg(Camk2a-tTA)1Mmay, Tg(Myh6-tTA)6Smbf, and Tg(Nes-rtTA)306Rvs), transgenic mice express luciferase in the appropiate tissue in a tetracycline-inducible fashion.