JAX
Mouse Strain Datasheet - 003238
C.129S2(B6)-Ciitatm1Ccum/J
Also Known As: CIITA-
These Ciita knock-out mice lack expression of conventional MHC class II molecules on the surface of splenic B cells and dendritic cells.
Donating Investigator
Dr. Richard A. Flavell, Yale University School of Medicine
Genetic overview
| Genetic Background | Generation |
|---|---|
|
BALB/c |
|
Ciitatm1Ccum
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Ciita | class II transactivator |
Research Applications
- Immunology, Inflammation and Autoimmunity Research
- Internal/Organ Research
- Research Tools
Detailed Description
Mice homozygous for the targeted mutation are viable and fertile when housed under specific pathogen-free conditions. Mice do not express conventional MHC class II molecules on the surface of splenic B cells and dendritic cells. In addition, interferon gamma stimulated peritoneal macrophages and somatic tissues from homozygous mutant mice do not express MHC class II molecules. The levels of invarient chain and H2m gene transcripts are substantially decreased in class II transactivator deficient mice. Homozygous mice have very few mature CD4 T cells in the periphery despite MHC class II expression in the thymus.
Control Suggestions
Selected References
- Fikrig E; Barthold SW; Chen M; Chang CH; Flavell RA. 1997. Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells. J Immunol 159(11):5682-6. PubMed: 9548512MGI: J:109903
Ciitatm1Ccum
Allele Symbol: Ciitatm1Ccum
| Allele Name | targeted mutation 1, Cheong-Hee Chang |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | C2tatm1Ccum; CIITA C-; CIITA-; MHC classII- |
| Gene Symbol and Name | Ciita, class II transactivator |
| Gene Synonym(s) | C2TA; C2ta; C2ta; CIITAIV; EG669998; Gm9475; Gm9475; MHC2TA; Mhc2ta; NLRA; predicted gene 9475; predicted gene, EG669998 |
| Strain of Origin | 129S2/SvPas |
| Chromosome | 16 |
| Molecular Note | A genomic fragment containing exons which encode critical regions of the protein was replaced with a neomycin selection gene. Northern blot analysis on RNA derived from homozygous mice demonstrated that no detectable protein was produced from this allele. |
| Mutations Made By | Dr. Cheong-Hee Chang, Indiana University |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
- MHC class II associated invariant chain deficient
- MHC class II defects
- MHC class II deficient
- T cell deficiency
- Immunodeficiency
- Internal/Organ Research
- Lymphoid Tissue Defects
- T cell deficiency
- Lymphoid Tissue Defects
- Research Tools
- Immunology, Inflammation and Autoimmunity Research
- MHC class II associated invariant chain deficiency
- MHC class II defects
- T cell deficiency
- Immunology, Inflammation and Autoimmunity Research
Genotype: Ciitatm1Ccum related
- Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
- Research Tools
- Immunology, Inflammation and Autoimmunity Research
- MHC class II defects
- Immunology, Inflammation and Autoimmunity Research
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Ciitatm1Ccum/Ciitatm1Ccum
involves: 129S2/SvPas * C57BL/6J
immune system phenotype
- abnormal B cell physiology
- the expression of IL-10 after stimulation with LPS of IL-4 for 3 days is enhanced in mutant B cells by about 2-3 fold (MGI Ref ID J:96421)
- abnormal CD4-positive, alpha-beta T cell physiology
- CD4+ T cell responses are significantly reduced to allogeneic stimulation (MGI Ref ID J:31601)
- when day 16 fetal liver cells are transferred into wild-type mice, CD4+ T cell development is normal and when wild-type fetal cells are transferred into homozygotes, CD4+ T cells fail to mature (MGI Ref ID J:31601)
- abnormal MHC II cell surface expression on macrophages
- macrophages do not express MHC II cell surface expression on interferon-gamma stimulation (MGI Ref ID J:31601)
- abnormal T cell differentiation
- (MGI Ref ID J:64283)
- abnormal T cell physiology
- (MGI Ref ID J:31601)
- abnormal cytokine secretion
- spleen and lymph node cells produced no measurable cytokines at 8 weeks after infection (MGI Ref ID J:64283)
- abnormal dendritic cell physiology
- Bone marrow-derived mutant dendritic cells in culture differentiate in response to GM-CSF despite absence of MHC class II molecules; however, when stimulated with LPS of CpG display about a 2-fold increase in IL-10 expression compared to wild-type (MGI Ref ID J:96421)
- abnormal level of surface class II molecules
- abnormal lymphocyte physiology
- (MGI Ref ID J:96421)
- abnormal popliteal lymph node morphology
- total numbers of cells in lymph nodes of null increased only slightly after infection with L. amazonensis compared with an 8-fold increase in size of wild-type (MGI Ref ID J:64283)
- altered susceptibility to infection
- (MGI Ref ID J:64283)
- decreased CD4-positive, alpha beta T cell number
- mice have reduced numbers of mature CD4+ T cells in the periphery (MGI Ref ID J:31601)
- decreased T cell proliferation
- T cells proliferate poorly in response to keyhole limpet hemocyanin stimulation compared to wild-type (MGI Ref ID J:31601)
- decreased susceptibility to parasitic infection
- after infection with L. Amazonensis, mice show no lesion development up to 11 weeks post infection, reduced cellular infiltration, lower parasite load and few cells in the popliteal lymph nodes draining the foot (MGI Ref ID J:64283)
- after infection with L. amazonensis, infected cells contained tightly packed organisms with few parasitophorous vacuole visible whereas infected macrophages in wild-type mice contained only a few organisms which are preferentially located at the edge of parasitophorous vacuolesarasitophorous vacuoles (MGI Ref ID J:64283)
- increased CD4-positive, alpha beta T cell number
- in spleen cells, there is a 4.5-fold increase of CD4+CD69high cells in mutants at 8 weeks after parasite infection (MGI Ref ID J:64283)
- increased CD8-positive, alpha-beta T cell number
- in spleen cell, a slight increase in the number of CD8+ T cells compared to wild-type is seen pre- and post-infection (MGI Ref ID J:64283)
- increased susceptibility to parasitic infection
- lesions become significantly larger with higher parasitic burdens 16 weeks after infection with L. major, compared to eventual lesion resolution in wild-type mice (MGI Ref ID J:64283)
hematopoietic system phenotype
- abnormal B cell physiology
- the expression of IL-10 after stimulation with LPS of IL-4 for 3 days is enhanced in mutant B cells by about 2-3 fold (MGI Ref ID J:96421)
- abnormal CD4-positive, alpha-beta T cell physiology
- CD4+ T cell responses are significantly reduced to allogeneic stimulation (MGI Ref ID J:31601)
- when day 16 fetal liver cells are transferred into wild-type mice, CD4+ T cell development is normal and when wild-type fetal cells are transferred into homozygotes, CD4+ T cells fail to mature (MGI Ref ID J:31601)
- abnormal MHC II cell surface expression on macrophages
- macrophages do not express MHC II cell surface expression on interferon-gamma stimulation (MGI Ref ID J:31601)
- abnormal T cell differentiation
- (MGI Ref ID J:64283)
- abnormal T cell physiology
- (MGI Ref ID J:31601)
- abnormal level of surface class II molecules
- abnormal lymphocyte physiology
- (MGI Ref ID J:96421)
- decreased CD4-positive, alpha beta T cell number
- mice have reduced numbers of mature CD4+ T cells in the periphery (MGI Ref ID J:31601)
- decreased T cell proliferation
- T cells proliferate poorly in response to keyhole limpet hemocyanin stimulation compared to wild-type (MGI Ref ID J:31601)
- increased CD4-positive, alpha beta T cell number
- in spleen cells, there is a 4.5-fold increase of CD4+CD69high cells in mutants at 8 weeks after parasite infection (MGI Ref ID J:64283)
- increased CD8-positive, alpha-beta T cell number
- in spleen cell, a slight increase in the number of CD8+ T cells compared to wild-type is seen pre- and post-infection (MGI Ref ID J:64283)
Genotype: Ciitatm1Ccum/Ciitatm1Ccum
involves: 129S2/SvPas * C57BL/6
immune system phenotype
- abnormal level of surface class II molecules
hematopoietic system phenotype
- abnormal level of surface class II molecules
References
- Fikrig E; Barthold SW; Chen M; Chang CH; Flavell RA. 1997. Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells. J Immunol 159(11):5682-6. PubMed: 9548512MGI: J:109903
Additional - Ciitatm1Ccum related
- Aichinger M; Wu C; Nedjic J; Klein L. 2013. Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance. J Exp Med 210(2):287-300. PubMed: 23382543MGI: J:196474
- Benito AI; Milner LA; Leisenring W; Deeg HJ; Woolfrey AE. 2001. Absence of major histocompatibility class II expression does not impair hematopoiesis in mice. Exp Hematol 29(9):1070-5. PubMed: 11532347MGI: J:111611
- Benlagha K; Park SH; Guinamard R; Forestier C; Karlsson L; Chang CH; Bendelac A. 2004. Mechanisms governing B cell developmental defects in invariant chain-deficient mice. J Immunol 172(4):2076-83. PubMed: 14764672MGI: J:87989
- Briseno CG; Gargaro M; Durai V; Davidson JT; Theisen DJ; Anderson DA 3rd; Novack DV; Murphy TL; Murphy KM. 2017. Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms. Proc Natl Acad Sci U S A 114(15):3957-3962. PubMed: 28348230MGI: J:242023
- Broxmeyer HE; Cooper S; Hangoc G; Chang CH. 2006. Class II transactivator-mediated regulation of major histocompatibility complex class II antigen expression is important for hematopoietic progenitor cell suppression by chemokines and iron-binding proteins. Exp Hematol 34(8):1078-84. PubMed: 16863914MGI: J:111903
- Buch T; Polic B; Clausen BE; Weiss S; Akilli-Ozturk O; Chang CH; Flavell R; Schulz A; Jonjic S; Waisman A; Forster I. 2006. MHC class II expression through a hitherto unknown pathway supports T helper cell-dependent immune responses: implications for MHC class II deficiency. Blood 107(4):1434-44. PubMed: 16254146MGI: J:129309
- Calabro S; Gallman A; Gowthaman U; Liu D; Chen P; Liu J; Krishnaswamy JK; Nascimento MS; Xu L; Patel SR; Williams A; Tormey CA; Hod EA; Spitalnik SL; Zimring JC; Hendrickson JE; Stowell SR; Eisenbarth SC. 2016. Bridging channel dendritic cells induce immunity to transfused red blood cells. J Exp Med 213(6):887-96. PubMed: 27185856MGI: J:234778
- Chang CH; Guerder S; Hong SC; van Ewijk W; Flavell RA. 1996. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Immunity 4(2):167-78. PubMed: 8624807MGI: J:31601
- Chen L; Jay DC; Fairbanks JD; He X; Jensen PE. 2011. An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus. J Immunol 187(12):6463-72. PubMed: 22084437MGI: J:180389
- Choi EY; Jung KC; Park HJ; Chung DH; Song JS; Yang SD; Simpson E; Park SH. 2005. Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells. Immunity 23(4):387-96. PubMed: 16226504MGI: J:113276
- Chou SD; Khan AN; Magner WJ; Tomasi TB. 2005. Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells. Int Immunol 17(11):1483-94. PubMed: 16210330MGI: J:104221
- Clausen BE; Waldburger JM; Schwenk F; Barras E; Mach B; Rajewsky K; Forster I; Reith W. 1998. Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity 8(2):143-55. PubMed: 9491996MGI: J:67941
- Creusot RJ; Yaghoubi SS; Kodama K; Dang DN; Dang VH; Breckpot K; Thielemans K; Gambhir SS; Fathman CG. 2008. Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol 127(2):176-87. PubMed: 18337172MGI: J:133579
- Das G; Das J; Eynott P; Zhang Y; Bothwell AL; Van Kaer L; Shi Y. 2006. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med 203(12):2603-11. PubMed: 17088432MGI: J:124622
- Devoss JJ; Shum AK; Johannes KP; Lu W; Krawisz AK; Wang P; Yang T; Leclair NP; Austin C; Strauss EC; Anderson MS. 2008. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol 181(6):4072-9. PubMed: 18768863MGI: J:139094
- Elliott EA; Drake JR; Amigorena S; Elsemore J; Webster P; Mellman I; Flavell RA. 1994. The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules. J Exp Med 179(2):681-94. PubMed: 8294875MGI: J:65917
- Eppert BL; Wortham BW; Flury JL; Borchers MT. 2013. Functional characterization of T cell populations in a mouse model of chronic obstructive pulmonary disease. J Immunol 190(3):1331-40. PubMed: 23264660MGI: J:192605
- Gourley T; Roys S; Lukacs NW; Kunkel SL; Flavell RA; Chang CH. 1999. A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production. Immunity 10(3):377-86. PubMed: 10204493MGI: J:54057
- Gourley TS; Patel DR; Nickerson K; Hong SC; Chang CH. 2002. Aberrant expression of Fas ligand in mice deficient for the MHC class II transactivator. J Immunol 168(9):4414-9. PubMed: 11970984MGI: J:112146
- Green EA; Wong FS; Eshima K; Mora C; Flavell RA. 2000. Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells. J Exp Med 191(2):225-38. PubMed: 10637268MGI: J:59409
- Guleria I; Gubbels Bupp M; Dada S; Fife B; Tang Q; Ansari MJ; Trikudanathan S; Vadivel N; Fiorina P; Yagita H; Azuma M; Atkinson M; Bluestone JA; Sayegh MH. 2007. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol 125(1):16-25. PubMed: 17627890MGI: J:125272
- Hepworth MR; Fung TC; Masur SH; Kelsen JR; McConnell FM; Dubrot J; Withers DR; Hugues S; Farrar MA; Reith W; Eberl G; Baldassano RN; Laufer TM; Elson CO; Sonnenberg GF. 2015. Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4(+) T cells. Science 348(6238):1031-5. PubMed: 25908663MGI: J:223811
- Hinterberger M; Aichinger M; da Costa OP; Voehringer D; Hoffmann R; Klein L. 2010. Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance. Nat Immunol 11(6):512-9. PubMed: 20431619MGI: J:160615
- Jay DC; Reed-Loisel LM; Jensen PE. 2008. Polyclonal MHC Ib-Restricted CD8+ T Cells Undergo Homeostatic Expansion in the Absence of Conventional MHC-Restricted T Cells. J Immunol 180(5):2805-14. PubMed: 18292501MGI: J:131725
- Kuipers H; Soullie T; Hammad H; Willart M; Kool M; Hijdra D; Hoogsteden HC; Lambrecht BN. 2009. Sensitization by intratracheally injected dendritic cells is independent of antigen presentation by host antigen-presenting cells. J Leukoc Biol 85(1):64-70. PubMed: 18923103MGI: J:143272
- Kupfer TM; Crawford ML; Pham K; Gill RG. 2005. MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo. J Immunol 175(4):2309-16. PubMed: 16081800MGI: J:107508
- Lauvau G; Vijh S; Kong P; Horng T; Kerksiek K; Serbina N; Tuma RA; Pamer EG. 2001. Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science 294(5547):1735-9. PubMed: 11721060MGI: J:133596
- Lee YJ; Jeon YK; Kang BH; Chung DH; Park CG; Shin HY; Jung KC; Park SH. 2010. Generation of PLZF+ CD4+ T cells via MHC class II-dependent thymocyte-thymocyte interaction is a physiological process in humans. J Exp Med 207(1):237-46, S1-7. PubMed: 20038602MGI: J:156545
- Li W; Kim MG; Gourley TS; McCarthy BP; Sant'Angelo DB; Chang CH. 2005. An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects a distinct T cell population. Immunity 23(4):375-86. PubMed: 16226503MGI: J:113275
- Li W; Sofi MH; Yeh N; Sehra S; McCarthy BP; Patel DR; Brutkiewicz RR; Kaplan MH; Chang CH. 2007. Thymic selection pathway regulates the effector function of CD4 T cells. J Exp Med 204(9):2145-57. PubMed: 17724129MGI: J:126084
- Ling W; Zhang J; Yuan Z; Ren G; Zhang L; Chen X; Rabson AB; Roberts AI; Wang Y; Shi Y. 2014. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res 74(5):1576-87. PubMed: 24452999MGI: J:208149
- Ludigs K; Seguin-Estevez Q; Lemeille S; Ferrero I; Rota G; Chelbi S; Mattmann C; MacDonald HR; Reith W; Guarda G. 2015. NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module. PLoS Genet 11(3):e1005088. PubMed: 25811463MGI: J:224219
- Mora C; Wong FS; Chang CH; Flavell RA. 1999. Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice. J Immunol 162(8):4576-88. PubMed: 10201997MGI: J:106081
- Ochi A; Nguyen AH; Bedrosian AS; Mushlin HM; Zarbakhsh S; Barilla R; Zambirinis CP; Fallon NC; Rehman A; Pylayeva-Gupta Y; Badar S; Hajdu CH; Frey AB; Bar-Sagi D; Miller G. 2012. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med 209(9):1671-87. PubMed: 22908323MGI: J:191814
- Otten LA; Leibundgut-Landmann S; Huarte J; Kos-Braun IC; Lavanchy C; Barras E; Borisch B; Steimle V; Acha-Orbea H; Reith W. 2006. Revisiting the specificity of the MHC class II transactivator CIITA in vivo. Eur J Immunol 36(6):1548-58. PubMed: 16703565MGI: J:152061
- Patel DR; Kaplan MH; Chang CH. 2004. Altered Th1 cell differentiation programming by CIITA deficiency. J Immunol 173(9):5501-8. PubMed: 15494498MGI: J:93745
- Pihlgren M; Silva AB; Madani R; Giriens V; Waeckerle-Men Y; Fettelschoss A; Hickman DT; Lopez-Deber MP; Ndao DM; Vukicevic M; Buccarello AL; Gafner V; Chuard N; Reis P; Piorkowska K; Pfeifer A; Kundig TM; Muhs A; Johansen P. 2013. TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice. Blood 121(1):85-94. PubMed: 23144170MGI: J:192819
- Qiao Y; Zhu L; Sofi H; Lapinski PE; Horai R; Mueller K; Stritesky GL; He X; Teh HS; Wiest DL; Kappes DJ; King PD; Hogquist KA; Schwartzberg PL; Sant'Angelo DB; Chang CH. 2012. Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. Proc Natl Acad Sci U S A 109(40):16264-9. PubMed: 22988097MGI: J:190112
- Romagnoli PA; Premenko-Lanier MF; Loria GD; Altman JD. 2013. CD8 T cell memory recall is enhanced by novel direct interactions with CD4 T cells enabled by MHC class II transferred from APCs. PLoS One 8(2):e56999. PubMed: 23441229MGI: J:199409
- Rubino SJ; Geddes K; Magalhaes JG; Streutker C; Philpott DJ; Girardin SE. 2013. Constitutive induction of intestinal Tc17 cells in the absence of hematopoietic cell-specific MHC class II expression. Eur J Immunol 43(11):2896-906. PubMed: 23881368MGI: J:203009
- Sawa S; Kamimura D; Jin GH; Morikawa H; Kamon H; Nishihara M; Ishihara K; Murakami M; Hirano T. 2006. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med 203(6):1459-70. PubMed: 16717113MGI: J:124381
- Sofi MH; Liu Z; Zhu L; Yu Q; Kaplan MH; Chang CH. 2010. Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus. Mol Immunol 47(6):1262-8. PubMed: 20080304MGI: J:158374
- Soong L; Chang CH; Sun J; Longley BJ Jr; Ruddle NH; Flavell RA; McMahon-Pratt D. 1997. Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection. J Immunol 158(11):5374-83. PubMed: 9164958MGI: J:64283
- Taniguchi RT; Devoss JJ; Moon JJ; Sidney J; Sette A; Jenkins MK; Anderson MS. 2012. Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A 109(20):7847-52. PubMed: 22552229MGI: J:184783
- Tazawa H; Irei T; Tanaka Y; Igarashi Y; Tashiro H; Ohdan H. 2013. Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates. Blood 122(15):2582-90. PubMed: 23943651MGI: J:203264
- Trautmann T; Kozik JH; Carambia A; Richter K; Lischke T; Schwinge D; Mittrucker HW; Lohse AW; Oxenius A; Wiegard C; Herkel J. 2014. CD4+ T-cell help is required for effective CD8+ T cell-mediated resolution of acute viral hepatitis in mice. PLoS One 9(1):e86348. PubMed: 24466045MGI: J:212565
- Winer DA; Winer S; Shen L; Wadia PP; Yantha J; Paltser G; Tsui H; Wu P; Davidson MG; Alonso MN; Leong HX; Glassford A; Caimol M; Kenkel JA; Tedder TF; McLaughlin T; Miklos DB; Dosch HM; Engleman EG. 2011. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 17(5):610-7. PubMed: 21499269MGI: J:171607
- Xu Y; Luchsinger L; Lucey EC; Smith BD. 2011. The effect of class II transactivator mutations on bleomycin-induced lung inflammation and fibrosis. Am J Respir Cell Mol Biol 44(6):898-905. PubMed: 20705943MGI: J:185026
- Xu Y; McDonald J; Perloff E; Buttice G; Schreiber BM; Smith BD. 2007. Collagen and major histocompatibility class II expression in mesenchymal cells from CIITA hypomorphic mice. Mol Immunol 44(7):1720-32. PubMed: 16982097MGI: J:115938
- Yang SJ; Ahn S; Park CS; Holmes KL; Westrup J; Chang CH; Kim MG. 2006. The quantitative assessment of MHC II on thymic epithelium: implications in cortical thymocyte development. Int Immunol 18(5):729-39. PubMed: 16569676MGI: J:108547
- Yee CS; Yao Y; Li P; Klemsz MJ; Blum JS; Chang CH. 2004. Cathepsin E: a novel target for regulation by class II transactivator. J Immunol 172(9):5528-34. PubMed: 15100295MGI: J:89650
- Yee CS; Yao Y; Xu Q; McCarthy B; Sun-Lin D; Tone M; Waldmann H; Chang CH. 2005. Enhanced production of IL-10 by dendritic cells deficient in CIITA. J Immunol 174(3):1222-9. PubMed: 15661876MGI: J:96421
- Young HY; Zucker P; Flavell RA; Jevnikar AM; Singh B. 2004. Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation. Transplantation 78(4):509-15. PubMed: 15446308MGI: J:107051
- Zhang B; Kracker S; Yasuda T; Casola S; Vanneman M; Homig-Holzel C; Wang Z; Derudder E; Li S; Chakraborty T; Cotter SE; Koyama S; Currie T; Freeman GJ; Kutok JL; Rodig SJ; Dranoff G; Rajewsky K. 2012. Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model. Cell 148(4):739-51. PubMed: 22341446MGI: J:181546