These Epor knock-out mice exhibit embryonic lethality with severe anemia. They are suitable for use in applications related to the study of hematopoiesis.
Leonard I. Zon, Children's Hospital
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Null/Knockout) | Epor | erythropoietin receptor |
Mice lacking Epor died in utero at embryonic day 11 - 12.5 with severe anemia. Embryonic erythropoiesis was markedly diminished, while fetal liver hematopoiesis was blocked at the proerythroblast stage. Homozygotes are not viable.
Allele Name | targeted mutation 1, Leonard I Zon |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | EpoR- |
Gene Symbol and Name | Epor, erythropoietin receptor |
Gene Synonym(s) | |
Strain of Origin | 129S4/SvJae |
Chromosome | 9 |
Molecular Note | A genomic fragment containing the splice acceptor site of exon 2 and all of exon 3 was replaced with a neomycin selection cassette. RT-PCR analysis on E12 peripheral blood of homozygous E12 embryos demonstrated that no detectable transcript was produced from this allele. |
Mutations Made By | Leonard Zon, Children's Hospital |
When maintaining a live colony, heterozygous mice may be bred to wildtype siblings. Homozygotes are not viable.
When using the EpoR- mouse strain in a publication, please cite the originating article(s) and include JAX stock #003213 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for Epor<tm1Liz> |
Frozen Mouse Embryo | B6;129S-Epor<tm1Lizon>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6;129S-Epor<tm1Lizon>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6;129S-Epor<tm1Lizon>/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6;129S-Epor<tm1Lizon>/J Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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