B6;129S-Epor^tm1Lizon/J

Stock number: 003213
Product name: EpoR-
Research areas: Developmental Biology Research, Hematological Research

Description

These Epor knock-out mice exhibit embryonic lethality with severe anemia. They are suitable for use in applications related to the study of hematopoiesis.

Detailed description

Mice lacking Epor died in utero at embryonic day 11 - 12.5 with severe anemia. Embryonic erythropoiesis was markedly diminished, while fetal liver hematopoiesis was blocked at the proerythroblast stage. Homozygotes are not viable.

Allele

Symbol: Epor^tm1Lizon
Name: targeted mutation 1, Leonard I Zon
MGI accession ID: MGI:1861922
Generation method: Targeted
Attributes: Null/Knockout
Synonyms: EpoR-
Marker symbol: Epor
Marker name: erythropoietin receptor
Marker synonyms: EPO-R
Chromosome: 9
Strain of origin: 129S4/SvJae
Molecular note: A genomic fragment containing the splice acceptor site of exon 2 and all of exon 3 was replaced with a neomycin selection cassette. RT-PCR analysis on E12 peripheral blood of homozygous E12 embryos demonstrated that no detectable transcript was produced from this allele.