Arnt-/- embryonic stem cells fail to activate genes that normally respond to low oxygen tension. They also fail to respond to a decrease in glucose concentration, indicating that ARNT is crucial in the response to hypoxia and to hypoglycaemia. Arnt-/- embryos were not viable past embryonic day 10.5 and showed defective angiogenesis of the yolk sac and branchial arches, stunted development and embryo wasting. The defect in blood vessel formation in Arnt-/- yolk sacs is similar to the angiogenic abnormalities reported for mice deficient in vascular endothelial growth factor or tissue factor.

These Arnt knock-out mice exhibit failure in response to hypoxia and to hypoglycaemia. They are suitable for use in applications related to the study of angiogenesis and vasoformation during mammalian embryonic development.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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