BALB/c sublines are susceptible to both cutaneous and visceral leishmaniases. The Andervont sublines of BALB/c, which include this strain and BALB/cByJ, lack antigenic expression of Qa2 and H2-Q3, but BALB/cJ expresses them (Flaherty et al., 1978 and 1985). Teuscher et al (1985) reported that BALB/cAnPt have an intermediate susceptibility to experimentally induced allergic orchitis (EAO), while BALB/cByJ is highly susceptible and BALB/cJ resistant. Most notably, BALB/cAnPt mice display a very high rate of induction of plasmacytomas, distinct from BALB/cJ, which is resistant to plasmacytoma induction (Merwin and Algire, 1959, Potter et al., 1962 and 1985) . BALB/cJ also differs from other BALB/c sublines in having a variant of Zhx2 and distinctly elevated serum alpha fetoprotein, which is found at reasonably normal levels in BALB/cAnPt (Olsson et al., 1977).
In 1937 Dr. Howard Andervont obtained from Drs. W. S. Murray and John Bittner some mice from Dr. George Snell?s BALB/c inbred, then at approximately F36. This line was maintained by Dr. Andervont at Bethesda, then passed to the main colony of NIH, and in 1964 Dr. Michael Potter obtained some mice of this line. The BALB/cAnPt inbred subline was imported directly from Dr. Potter at NCI to Dr. Larry Mobraaten at The Jackson Laboratory in 1994. The colony was immediately expanded and embryos were generated for cryopreservation.
|Gene Symbol and Name||Pcts, plasmacytoma susceptibility|
|Strain of Origin||BALB/cAnPt|
|Molecular Note||This allele confers susceptibility to pristane-induced plasmacytomas compared to DBA/2N.|