BALB/c sublines are susceptible to both cutaneous and visceral leishmaniases. The Andervont sublines of BALB/c, which include this strain and BALB/cByJ, lack antigenic expression of Qa2 and H2-Q3, but BALB/cJ expresses them (Flaherty et al., 1978 and 1985). Teuscher et al (1985) reported that BALB/cAnPt have an intermediate susceptibility to experimentally induced allergic orchitis (EAO), while BALB/cByJ is highly susceptible and BALB/cJ resistant. Most notably, BALB/cAnPt mice display a very high rate of induction of plasmacytomas, distinct from BALB/cJ, which is resistant to plasmacytoma induction (Merwin and Algire, 1959, Potter et al., 1962 and 1985) . BALB/cJ also differs from other BALB/c sublines in having a variant of Zhx2 and distinctly elevated serum alpha fetoprotein, which is found at reasonably normal levels in BALB/cAnPt (Olsson et al., 1977).
In 1937 Dr. Howard Andervont obtained from Drs. W. S. Murray and John Bittner some mice from Dr. George Snell?s BALB/c inbred, then at approximately F36. This line was maintained by Dr. Andervont at Bethesda, then passed to the main colony of NIH, and in 1964 Dr. Michael Potter obtained some mice of this line. The BALB/cAnPt inbred subline was imported directly from Dr. Potter at NCI to Dr. Larry Mobraaten at The Jackson Laboratory in 1994. The colony was immediately expanded and embryos were generated for cryopreservation.
Allele Name | BALB/cAnPt |
---|---|
Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Skts4, skin tumor susceptibility 4 |
Gene Synonym(s) | |
Strain of Origin | BALB/cAnPt |
Chromosome | 5 |
Allele Name | BALB/cAnPt |
---|---|
Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Cdkn2a, cyclin dependent kinase inhibitor 2A |
Gene Synonym(s) | |
Strain of Origin | BALB/cAnPt |
Chromosome | 4 |
Allele Name | BALB/cAnPt |
---|---|
Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Pcts, plasmacytoma susceptibility |
Gene Synonym(s) | |
Strain of Origin | BALB/cAnPt |
Chromosome | 4 |
Molecular Note | This allele confers susceptibility to pristane-induced plasmacytomas compared to DBA/2N. |
Allele Name | BALB/cAnPt |
---|---|
Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Pctm, plasmacytoma modifier |
Gene Synonym(s) | |
Strain of Origin | BALB/cAnPt |
Chromosome | 1 |
Molecular Note | This allele confers resistance to pristane-induced plasmacytomas compared to DBA/2N. |
Allele Name | BALB/cAnPt |
---|---|
Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Ltxs2, lethal factor toxin susceptibility 2 |
Gene Synonym(s) | |
Strain of Origin | BALB/cAnPt |
Chromosome | 11 |
Allele Name | BALB/cAnPt |
---|---|
Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Ltxs3, lethal factor toxin susceptibility 3 |
Gene Synonym(s) | |
Strain of Origin | BALB/cAnPt |
Chromosome | 11 |
When using the BALB/cAnPtJ mouse strain in a publication, please include JAX stock #003151 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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