homeostasis/metabolism phenotype

• increased circulating parathyroid hormone level
  (MGI Ref ID J:52026)

• increased circulating prolactin level
  • 40-fold
  (MGI Ref ID J:52026)

• decreased circulating progesterone level
  • in female mice
  (MGI Ref ID J:52026)

• decreased circulating estradiol level
  • in female mice
  (MGI Ref ID J:52026)

• abnormal circulating calcium level
  (MGI Ref ID J:52026)

skeleton phenotype

• abnormal bone ossification
  • the distance between mineralization fronts is decreased compared to in wild-type mice
  (MGI Ref ID J:52026)
  • bone formation is decreased 60% compared to in wild-type mice
  (MGI Ref ID J:52026)

• delayed bone ossification
  • in the calvaria at E18.5
  (MGI Ref ID J:52026)

• abnormal bone mineralization
  • trabecular and cortical long bone mineral apposition rates are less than in wild-type mice
  (MGI Ref ID J:52026)
  • Normal - however, mineralizing and osteoblast surfaces are normal
  (MGI Ref ID J:52026)

• decreased bone mass
  • at 4 months of age as measured by bone mineral density and bone mineral content
  (MGI Ref ID J:52026)

mammalian phenotype

• vision/eye phenotype
  • Normal - mice exhibit normal IgA tear composition and strain sensitivity to conjunctivitis
  (MGI Ref ID J:66544)

reproductive system phenotype

• abnormal prostate gland epithelium morphology
  • Normal - however, no difference is observed in castrated mice
  (MGI Ref ID J:84352)
  • prostate epithelial content is reduced compared to in wild-type mice
  (MGI Ref ID J:84352)

• male infertility
  • more mice exhibit total infertility than wild-type mice
  (MGI Ref ID J:84352)

• increased seminal vesicle weight
  • in mature, but not young, mice
  (MGI Ref ID J:84352)

• reduced male fertility
  • latency to first litter conceived by male mice is delayed compared to for wild-type mice
  (MGI Ref ID J:84352)

• increased prostate gland weight
  • ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice
  (MGI Ref ID J:84352)

• abnormal prostate gland ventral lobe morphology
  • ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice
  (MGI Ref ID J:84352)

endocrine/exocrine gland phenotype

• abnormal Harderian gland morphology
  • male mice exhibit a 10% increase in acinar cell density compared with wild-type mice
  (MGI Ref ID J:66544)
  • Normal - however, the Harderian gland in female mice is normal
  (MGI Ref ID J:66544)

• increased seminal vesicle weight
  • in mature, but not young, mice
  (MGI Ref ID J:84352)

• abnormal lacrimal gland morphology
  • male mice exhibit a small reduction in lacrimal gland acini per field compared to in wild-type mice due to a decrease in acinar area associated with an increase in acinar cell density
  (MGI Ref ID J:66544)
  • Normal - however, the lacrimal gland in female mice is normal and castration of male mice restores normal lacrimal gland morphology
  (MGI Ref ID J:66544)

• abnormal prostate gland ventral lobe morphology
  • ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice
  (MGI Ref ID J:84352)

• abnormal prostate gland epithelium morphology
  • prostate epithelial content is reduced compared to in wild-type mice
  (MGI Ref ID J:84352)
  • Normal - however, no difference is observed in castrated mice
  (MGI Ref ID J:84352)

• abnormal Harderian gland porphyrin secretion
  • male and female mice exhibit a decrease in solid porphyrin accretions compared with wild-type mice
  (MGI Ref ID J:66544)

• increased prostate gland weight
  • ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice
  (MGI Ref ID J:84352)

vision/eye phenotype

• abnormal lacrimal gland morphology
  • male mice exhibit a small reduction in lacrimal gland acini per field compared to in wild-type mice due to a decrease in acinar area associated with an increase in acinar cell density
  (MGI Ref ID J:66544)
  • Normal - however, the lacrimal gland in female mice is normal and castration of male mice restores normal lacrimal gland morphology
  (MGI Ref ID J:66544)

adipose tissue phenotype

• decreased abdominal fat pad weight
  • in male and female mice at 8 to 9 months of age
  (MGI Ref ID J:67354)

growth/size/body region phenotype

• decreased body weight
  • in female, but not male mice, at 27 to 37 weeks of age
  (MGI Ref ID J:67354)
  • in female and male mice at 42 to 76 weeks of age
  (MGI Ref ID J:67354)
  • female mice exhibit a greater reduction in body weight than male mice
  (MGI Ref ID J:67354)

• slow postnatal weight gain
  • in male and female mice
  (MGI Ref ID J:67354)

homeostasis/metabolism phenotype

• decreased insulin secretion
  • insulin secretion in response to glucose is blunted compared to in similarly treated wild-type mice
  (MGI Ref ID J:106829)
  • islet insulin content is reduced compared to in wild-type cells
  (MGI Ref ID J:106829)

• decreased circulating leptin level
  • in female, but not male, mice at 7 to 9 months of age
  (MGI Ref ID J:67354)

• impaired glucose tolerance
  • mild
  (MGI Ref ID J:106829)

endocrine/exocrine gland phenotype

• decreased insulin secretion
  • insulin secretion in response to glucose is blunted compared to in similarly treated wild-type mice
  (MGI Ref ID J:106829)
  • islet insulin content is reduced compared to in wild-type cells
  (MGI Ref ID J:106829)

• abnormal pancreatic islet morphology
  • islet density is increased in weanling males and adult male and female mice compared to in wild-type mice
  (MGI Ref ID J:106829)

• small pancreatic islets
  • Normal - however, adult male and female mice exhibit normal islet size
  (MGI Ref ID J:106829)
  • islet size in weanling males is decreased compared to in wild-type mice
  (MGI Ref ID J:106829)

• decreased pancreatic beta cell mass
  • beta cell fraction and mass are reduced in male and female mice compared to in wild-type mice
  (MGI Ref ID J:106829)

behavior/neurological phenotype

• abnormal sexual interaction
  • females showed increased mating frequency
  (MGI Ref ID J:38093)

reproductive system phenotype

• reduced male fertility
  • Background Sensitivity - on a mixed background, 5 of 15 males were showed impaired fertility
  (MGI Ref ID J:38093)
  • 5 of 15 males were showed impaired fertility
  (MGI Ref ID J:38093)

• abnormal reproductive system physiology
  • defective pre-implantation embryonic development
  (MGI Ref ID J:38093)
  • mating did not induce pseudopregnancy
  (MGI Ref ID J:38093)
  • fertilization was impaired
  (MGI Ref ID J:38093)

• male infertility
  • 3 of 15 males were infertile
  (MGI Ref ID J:38093)
  • Background Sensitivity - on a mixed background, 3 of 15 males were infertile
  (MGI Ref ID J:38093)

• abnormal decidualization
  • the uterus was refractory to implantation, though occasional implanted blastocysts were observed
  (MGI Ref ID J:38093)
  • fertilized single and two-cell stage embryos were viable when reimplanted into pseudopregnant (C57BL/6 x CBA)F1 hosts
  (MGI Ref ID J:38093)

• abnormal oogenesis
  • immature oocytes were released from the ovary
  (MGI Ref ID J:38093)

• decreased primary ovarian follicle number
  • reduced number of primary follicles
  (MGI Ref ID J:38093)

• abnormal oviduct environment
  (MGI Ref ID J:38093)

• abnormal uterine environment
  (MGI Ref ID J:38093)

• abnormal ovulation
  • fewer than normal eggs are ovulated
  (MGI Ref ID J:38093)

• female infertility
  (MGI Ref ID J:38093)

embryo phenotype

• abnormal decidualization
  • the uterus was refractory to implantation, though occasional implanted blastocysts were observed
  (MGI Ref ID J:38093)
  • fertilized single and two-cell stage embryos were viable when reimplanted into pseudopregnant (C57BL/6 x CBA)F1 hosts
  (MGI Ref ID J:38093)

endocrine/exocrine gland phenotype

• decreased primary ovarian follicle number
  • reduced number of primary follicles
  (MGI Ref ID J:38093)

mammalian phenotype

• behavior/neurological phenotype
  • Normal - mice exhibit normal spatial learning in a Morris water maze test
  (MGI Ref ID J:83247)

• taste/olfaction phenotype
  • Normal - mice exhibit normal olfaction
  (MGI Ref ID J:83247)

skeleton phenotype

• decreased bone mineral density
  • slightly in female mice but not male mice
  (MGI Ref ID J:95779)

behavior/neurological phenotype

• abnormal pup retrieval
  • virgin females take 6 days of daily exposure sessions to fostered pups to retrieve them if they retrieve them at all compared with 1 or 2 daily exposure sessions for wild-type mice
  (MGI Ref ID J:83247)

• abnormal maternal behavior
  • virgin females fail to develop full maternal behavior towards fostered pups even after 6 days of exposure compared with wild-type mice that require only 1-2 days of exposure
  (MGI Ref ID J:83247)

growth/size/body region phenotype

• slow postnatal weight gain
  • after 4 months, female mice exhibit deficient weight gain compared with wild-type mice
  (MGI Ref ID J:95779)

• decreased body weight
  • Normal - however, male mice exhibit normal body weight
  (MGI Ref ID J:95779)
  • female mice exhibit decreased body weight compared with wild-type mice
  (MGI Ref ID J:95779)

integument phenotype

• abnormal hair cycle
  • after G2, hair replacement is advanced compared to in wild-type mice
  (MGI Ref ID J:70207)
  • after G2, mice no longer exhibit sexual dimorphism in fiber eruption unlike in wild-type mice
  (MGI Ref ID J:70207)

• coarse hair
  • slightly after G2
  (MGI Ref ID J:70207)

• abnormal coat/ hair morphology
  • mice have longer hair compared with wild-type mice
  (MGI Ref ID J:70207)

endocrine/exocrine gland phenotype

• increased thyroid carcinoma incidence
  • mice develop medullary thyroid carcinomas unlike wild-type mice
  (MGI Ref ID J:101609)

• abnormal thyroid gland morphology
  • at 2, 4, and 5 months of age, thyroid gland weight is increased compared to in wild-type mice
  (MGI Ref ID J:101609)
  • mice exhibit an increase in mucus cell-like structures in the thyroid gland compared to in wild-type mice
  (MGI Ref ID J:101609)

homeostasis/metabolism phenotype

• decreased body temperature
  (MGI Ref ID J:101609)

• decreased thyroxine level
  • serum-free T4 levels are lower than in wild-type mice
  (MGI Ref ID J:101609)

mammalian phenotype

• homeostasis/metabolism phenotype
  • Background Sensitivity - on a predominantly 129/Sv background, follicle stimulating hormone, luteinizing hormone, and testosterone plasma levels are normal
  (MGI Ref ID J:85593)

• reproductive system phenotype
  • Background Sensitivity - on a predominantly 129/Sv background, male mice exhibit normal reproductive morphology and fertility
  (MGI Ref ID J:85593)

neoplasm

• increased thyroid carcinoma incidence
  • mice develop medullary thyroid carcinomas unlike wild-type mice
  (MGI Ref ID J:101609)

behavior/neurological phenotype

• abnormal pup retrieval
  • when the mother reformed the nest, a pup was often left outside and not retrieved, whereas the others were suckled
  (MGI Ref ID J:38093)

• abnormal maternal nurturing
  • some mothers scattered their pups, often burying them in sawdust
  (MGI Ref ID J:38093)

endocrine/exocrine gland phenotype

• abnormal mammary gland development
  • impaired development after first, but not subsequent, pregnancies
  (MGI Ref ID J:38093)

• abnormal lactation
  • failure of lactation attributable after first, but not subsequent, pregancies
  (MGI Ref ID J:38093)

integument phenotype

• abnormal mammary gland development
  • impaired development after first, but not subsequent, pregnancies
  (MGI Ref ID J:38093)

• abnormal lactation
  • failure of lactation attributable after first, but not subsequent, pregancies
  (MGI Ref ID J:38093)

behavior/neurological phenotype

• abnormal maternal behavior
  • virgin female require 4 days to develop full maternal behavior towards fostered pups compared with 1 or 2 days for wild-type mice
  (MGI Ref ID J:83247)

• abnormal pup retrieval
  • virgin females take 4 to 5 days of daily exposure sessions to fostered pups to retrieve them compared with 1 or 2 daily exposure sessions for wild-type mice
  (MGI Ref ID J:83247)

integument phenotype

• abnormal hair cycle
  • intermediate timing of molting relative to homozygotes and wild-type mice
  (MGI Ref ID J:70207)

mammalian phenotype

• taste/olfaction phenotype
  • Normal - mice exhibit normal olfaction
  (MGI Ref ID J:83247)

• behavior/neurological phenotype
  • Normal - mice exhibit normal spatial learning in a Morris water maze test
  (MGI Ref ID J:83247)

endocrine/exocrine gland phenotype

• abnormal mammary gland development
  • at 2 days postpartum, lobuloalveolar structures are underdeveloped compared to in wild-type mice
  (MGI Ref ID J:70408)

integument phenotype

• abnormal mammary gland development
  • at 2 days postpartum, lobuloalveolar structures are underdeveloped compared to in wild-type mice
  (MGI Ref ID J:70408)

cellular phenotype

• abnormal neuron proliferation
  • at gestation day 7, mated females exhibit less of an increase in forebrain neurogenesis compared with mated wild-type mice
  (MGI Ref ID J:83248)

nervous system phenotype

• abnormal neuron proliferation
  • at gestation day 7, mated females exhibit less of an increase in forebrain neurogenesis compared with mated wild-type mice
  (MGI Ref ID J:83248)