JAX
Mouse Strain Datasheet - 003142
B6.129P2-Prlrtm1Cnp/J
Also Known As: PRLR-
Homozygous female Prlr knock-out mice exhibit infertility and lack of mammary development.
Donating Investigator
Dr. Paul A. Kelly, Faculte de Medecine Necker
Genetic overview
| Genetic Background | Generation |
|---|---|
|
C57BL/6 |
|
Prlrtm1Cnp
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Prlr | prolactin receptor |
Research Applications
- Cancer Research
- Developmental Biology Research
- Endocrine Deficiency Research
- Neurobiology Research
- Reproductive Biology Research
Detailed Description
There is complete female sterility due to abberant estrous cycles, abnormal preimplantation development of eggs, no implantation of blastocysts, lack of pseudopregnancy. Males show slightly delayed fertility. Mammary development is markedly affected. Homozygotes have no mammary development and do not lactate. Heterozygotes are unable to lactate after the first pregnancies, but attain some degree of lactation as they age or after multiple pregnancies. Serum prolactin levels are increased 60 - 100 fold in both males and females. Maternal behavior is diminished in pimiparous and nulliparous animals. Bone remodelling is decreased in homozygote mutants.
Development
Exon 5 was replaced with the neomycin resistance gene driven by the thymidine kinase promotor. The truncated mRNA, if produced, would encode a protein of only 44 amino acids, unable to bind the hormone and produce any biological action. The targeting construct was electroporated into 129P2/OlaHsd-derived E14.1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts. The resulting chimeric animals were bred to crossed to C57BL/6 and offspring were backcrossed to C57BL/6 for at least 10 generations.
Control Suggestions
- Wild-type from the colony
- 000664 C57BL/6J
Additional Information
Selected References
- Ormandy CJ; Camus A; Barra J; Damotte D; Lucas B; Buteau H; Edery M; Brousse N; Babinet C; Binart N; Kelly PA. 1997. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev 11(2):167-78. PubMed: 9009200MGI: J:38093
Prlrtm1Cnp
Allele Symbol: Prlrtm1Cnp
| Allele Name | targeted mutation 1, Paul A Kelly |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | PRLRko; Prlr- |
| Gene Symbol and Name | Prlr, prolactin receptor |
| Gene Synonym(s) | AI987712; HPRL; MFAB; Pr-1; Pr-1; Pr-3; Prlr-rs1; Prlr-rs1; RATPRLR; expressed sequence AI987712; hPRLrI; prolactin receptor 1; prolactin receptor 3; prolactin receptor related sequence 1 |
| Strain of Origin | 129P2/OlaHsd |
| Chromosome | 15 |
| Molecular Note | A neomycin cassette was inserted into exon 5, creating an in-frame stop codon. Northern, Western, and binding data all demonstrate the lack of a functional receptor in homozygous mutant animals. |
| Mutations Made By | Dr. Paul Kelly, Faculte de Medecine Necker |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Prlrtm1Cnp related
- Cancer Research
- Growth Factors/Receptors/Cytokines
- Developmental Biology Research
- Skeletal Defects
- Endocrine Deficiency Research
- Bone/Bone Marrow Defects
- Mammary Gland Defects
- Pancreas Defects
- Neurobiology Research
- Behavioral and Learning Defects
- Reproductive Biology Research
- Endocrine Deficiencies Affecting Gonads
- Fertility Defects
Mammalian Phenotype Terms by Genotype
Genotype: Prlrtm1Cnp/Prlr+
B6.129P2-Prlrtm1Cnp/J
nervous system phenotype
- abnormal neuron proliferation
- at gestation day 7, mated females exhibit less of an increase in forebrain neurogenesis compared with mated wild-type mice (MGI Ref ID J:83248)
cellular phenotype
- abnormal neuron proliferation
- at gestation day 7, mated females exhibit less of an increase in forebrain neurogenesis compared with mated wild-type mice (MGI Ref ID J:83248)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Prlrtm1Cnp/Prlr+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
endocrine/exocrine gland phenotype
- abnormal mammary gland development
- at 2 days postpartum, lobuloalveolar structures are underdeveloped compared to in wild-type mice (MGI Ref ID J:70408)
integument phenotype
- abnormal mammary gland development
- at 2 days postpartum, lobuloalveolar structures are underdeveloped compared to in wild-type mice (MGI Ref ID J:70408)
Genotype: Prlrtm1Cnp/Prlr+
involves: 129P2/OlaHsd
behavior/neurological phenotype
- abnormal maternal behavior
- virgin female require 4 days to develop full maternal behavior towards fostered pups compared with 1 or 2 days for wild-type mice (MGI Ref ID J:83247)
- abnormal pup retrieval
- virgin females take 4 to 5 days of daily exposure sessions to fostered pups to retrieve them compared with 1 or 2 daily exposure sessions for wild-type mice (MGI Ref ID J:83247)
- behavior/neurological phenotype
- mice exhibit normal spatial learning in a Morris water maze test (MGI Ref ID J:83247)
taste/olfaction phenotype
- taste/olfaction phenotype
- mice exhibit normal olfaction (MGI Ref ID J:83247)
integument phenotype
- abnormal hair cycle
- intermediate timing of molting relative to homozygotes and wild-type mice (MGI Ref ID J:70207)
Genotype: Prlrtm1Cnp/Prlr+
either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
behavior/neurological phenotype
- abnormal maternal nurturing
- some mothers scattered their pups, often burying them in sawdust (MGI Ref ID J:38093)
- abnormal pup retrieval
- when the mother reformed the nest, a pup was often left outside and not retrieved, whereas the others were suckled (MGI Ref ID J:38093)
endocrine/exocrine gland phenotype
- abnormal lactation
- failure of lactation attributable after first, but not subsequent, pregancies (MGI Ref ID J:38093)
- abnormal mammary gland development
- impaired development after first, but not subsequent, pregnancies (MGI Ref ID J:38093)
integument phenotype
- abnormal lactation
- failure of lactation attributable after first, but not subsequent, pregancies (MGI Ref ID J:38093)
- abnormal mammary gland development
- impaired development after first, but not subsequent, pregnancies (MGI Ref ID J:38093)
Genotype: Prlrtm1Cnp/Prlrtm1Cnp
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
skeleton phenotype
- abnormal bone mineralization
- abnormal bone ossification
- decreased bone mass
- at 4 months of age as measured by bone mineral density and bone mineral content (MGI Ref ID J:52026)
- delayed bone ossification
- in the calvaria at E18.5 (MGI Ref ID J:52026)
homeostasis/metabolism phenotype
- abnormal circulating calcium level
- (MGI Ref ID J:52026)
- decreased circulating estradiol level
- in female mice (MGI Ref ID J:52026)
- decreased circulating progesterone level
- in female mice (MGI Ref ID J:52026)
- increased circulating parathyroid hormone level
- (MGI Ref ID J:52026)
- increased circulating prolactin level
- 40-fold (MGI Ref ID J:52026)
Genotype: Prlrtm1Cnp/Prlrtm1Cnp
involves: 129P2/OlaHsd
behavior/neurological phenotype
- abnormal maternal behavior
- virgin females fail to develop full maternal behavior towards fostered pups even after 6 days of exposure compared with wild-type mice that require only 1-2 days of exposure (MGI Ref ID J:83247)
- abnormal pup retrieval
- virgin females take 6 days of daily exposure sessions to fostered pups to retrieve them if they retrieve them at all compared with 1 or 2 daily exposure sessions for wild-type mice (MGI Ref ID J:83247)
- behavior/neurological phenotype
- mice exhibit normal spatial learning in a Morris water maze test (MGI Ref ID J:83247)
growth/size/body region phenotype
- decreased body weight
- slow postnatal weight gain
- after 4 months, female mice exhibit deficient weight gain compared with wild-type mice (MGI Ref ID J:95779)
skeleton phenotype
- decreased bone mineral density
- slightly in female mice but not male mice (MGI Ref ID J:95779)
taste/olfaction phenotype
- taste/olfaction phenotype
- mice exhibit normal olfaction (MGI Ref ID J:83247)
integument phenotype
- abnormal coat/ hair morphology
- mice have longer hair compared with wild-type mice (MGI Ref ID J:70207)
- abnormal hair cycle
- coarse hair
- slightly after G2 (MGI Ref ID J:70207)
Genotype: Prlrtm1Cnp/Prlrtm1Cnp
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
endocrine/exocrine gland phenotype
- abnormal pancreatic islet morphology
- islet density is increased in weanling males and adult male and female mice compared to in wild-type mice (MGI Ref ID J:106829)
- decreased insulin secretion
- decreased pancreatic beta cell mass
- beta cell fraction and mass are reduced in male and female mice compared to in wild-type mice (MGI Ref ID J:106829)
- small pancreatic islets
growth/size/body region phenotype
- decreased body weight
- slow postnatal weight gain
- in male and female mice (MGI Ref ID J:67354)
homeostasis/metabolism phenotype
- decreased circulating leptin level
- in female, but not male, mice at 7 to 9 months of age (MGI Ref ID J:67354)
- decreased insulin secretion
- impaired glucose tolerance
- mild (MGI Ref ID J:106829)
adipose tissue phenotype
- decreased abdominal fat pad weight
- in male and female mice at 8 to 9 months of age (MGI Ref ID J:67354)
Genotype: Prlrtm1Cnp/Prlrtm1Cnp
involves: 129P2/OlaHsd * 129S2/SvPas
reproductive system phenotype
- abnormal prostate gland epithelium morphology
- abnormal prostate gland ventral lobe morphology
- ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice (MGI Ref ID J:84352)
- increased prostate gland weight
- ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice (MGI Ref ID J:84352)
- increased seminal vesicle weight
- in mature, but not young, mice (MGI Ref ID J:84352)
- male infertility
- more mice exhibit total infertility than wild-type mice (MGI Ref ID J:84352)
- reduced male fertility
- latency to first litter conceived by male mice is delayed compared to for wild-type mice (MGI Ref ID J:84352)
vision/eye phenotype
- abnormal lacrimal gland morphology
- however, the lacrimal gland in female mice is normal and castration of male mice restores normal lacrimal gland morphology (MGI Ref ID J:66544)
- male mice exhibit a small reduction in lacrimal gland acini per field compared to in wild-type mice due to a decrease in acinar area associated with an increase in acinar cell density (MGI Ref ID J:66544)
- vision/eye phenotype
- mice exhibit normal IgA tear composition and strain sensitivity to conjunctivitis (MGI Ref ID J:66544)
endocrine/exocrine gland phenotype
- abnormal Harderian gland morphology
- abnormal Harderian gland porphyrin secretion
- male and female mice exhibit a decrease in solid porphyrin accretions compared with wild-type mice (MGI Ref ID J:66544)
- abnormal lacrimal gland morphology
- however, the lacrimal gland in female mice is normal and castration of male mice restores normal lacrimal gland morphology (MGI Ref ID J:66544)
- male mice exhibit a small reduction in lacrimal gland acini per field compared to in wild-type mice due to a decrease in acinar area associated with an increase in acinar cell density (MGI Ref ID J:66544)
- abnormal prostate gland epithelium morphology
- abnormal prostate gland ventral lobe morphology
- ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice (MGI Ref ID J:84352)
- increased prostate gland weight
- ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice (MGI Ref ID J:84352)
- increased seminal vesicle weight
- in mature, but not young, mice (MGI Ref ID J:84352)
Genotype: Prlrtm1Cnp/Prlrtm1Cnp
either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
behavior/neurological phenotype
- abnormal sexual interaction
- females showed increased mating frequency (MGI Ref ID J:38093)
endocrine/exocrine gland phenotype
- decreased primary ovarian follicle number
- reduced number of primary follicles (MGI Ref ID J:38093)
reproductive system phenotype
- abnormal decidualization
- abnormal oogenesis
- immature oocytes were released from the ovary (MGI Ref ID J:38093)
- abnormal oviduct environment
- (MGI Ref ID J:38093)
- abnormal ovulation
- fewer than normal eggs are ovulated (MGI Ref ID J:38093)
- abnormal reproductive system physiology
- abnormal uterine environment
- (MGI Ref ID J:38093)
- decreased primary ovarian follicle number
- reduced number of primary follicles (MGI Ref ID J:38093)
- female infertility
- (MGI Ref ID J:38093)
- male infertility
- reduced male fertility
embryo phenotype
Genotype: Prlrtm1Cnp/Prlrtm1Cnp
involves: 129/Sv * 129P2/OlaHsd
reproductive system phenotype
- reproductive system phenotype
- Background Sensitivity - on a predominantly 129/Sv background, male mice exhibit normal reproductive morphology and fertility (MGI Ref ID J:85593)
homeostasis/metabolism phenotype
- decreased body temperature
- (MGI Ref ID J:101609)
- decreased thyroxine level
- serum-free T4 levels are lower than in wild-type mice (MGI Ref ID J:101609)
- homeostasis/metabolism phenotype
- Background Sensitivity - on a predominantly 129/Sv background, follicle stimulating hormone, luteinizing hormone, and testosterone plasma levels are normal (MGI Ref ID J:85593)
endocrine/exocrine gland phenotype
- abnormal thyroid gland morphology
- increased thyroid carcinoma incidence
- mice develop medullary thyroid carcinomas unlike wild-type mice (MGI Ref ID J:101609)
neoplasm
- increased thyroid carcinoma incidence
- mice develop medullary thyroid carcinomas unlike wild-type mice (MGI Ref ID J:101609)
References
- Ormandy CJ; Camus A; Barra J; Damotte D; Lucas B; Buteau H; Edery M; Brousse N; Babinet C; Binart N; Kelly PA. 1997. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev 11(2):167-78. PubMed: 9009200MGI: J:38093
Additional - Prlrtm1Cnp related
- Adan N; Guzman-Morales J; Ledesma-Colunga MG; Perales-Canales SI; Quintanar-Stephano A; Lopez-Barrera F; Mendez I; Moreno-Carranza B; Triebel J; Binart N; Martinez de la Escalera G; Thebault S; Clapp C. 2013. Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis. J Clin Invest 123(9):3902-13. PubMed: 23908112MGI: J:201633
- Allan GJ; Tonner E; Barber MC; Travers MT; Shand JH; Vernon RG; Kelly PA; Binart N; Flint DJ. 2002. Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor. Endocrinology 143(11):4310-9. PubMed: 12399427MGI: J:80470
- Arnold E; Thebault S; Baeza-Cruz G; Arredondo Zamarripa D; Adan N; Quintanar-Stephano A; Condes-Lara M; Rojas-Piloni G; Binart N; Martinez de la Escalera G; Clapp C. 2014. The hormone prolactin is a novel, endogenous trophic factor able to regulate reactive glia and to limit retinal degeneration. J Neurosci 34(5):1868-78. PubMed: 24478366MGI: J:206956
- Auffret J; Freemark M; Carre N; Mathieu Y; Tourrel-Cuzin C; Lombes M; Movassat J; Binart N. 2013. Defective prolactin signaling impairs pancreatic beta-cell development during the perinatal period. Am J Physiol Endocrinol Metab 305(10):E1309-18. PubMed: 24064341MGI: J:205003
- Bachelot A; Beaufaron J; Servel N; Kedzia C; Monget P; Kelly PA; Gibori G; Binart N. 2009. Prolactin independent rescue of mouse corpus luteum life span: identification of prolactin and luteinizing hormone target genes. Am J Physiol Endocrinol Metab 297(3):E676-84. PubMed: 19531635MGI: J:152499
- Bachelot A; Carre N; Mialon O; Matelot M; Servel N; Monget P; Ahtiainen P; Huhtaniemi I; Binart N. 2013. The permissive role of prolactin as a regulator of luteinizing hormone action in the female mouse ovary and extragonadal tumorigenesis. Am J Physiol Endocrinol Metab 305(7):E845-52. PubMed: 23921141MGI: J:203878
- Baran N; Kelly PA; Binart N. 2002. Characterization of a prolactin-regulated gene in reproductive tissues usingthe prolactin receptor knockout mouse model. Biol Reprod 66(4):1210-8. PubMed: 11906943MGI: J:75701
- Belugin S; Diogenes AR; Patil MJ; Ginsburg E; Henry MA; Akopian AN. 2013. Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons. J Biol Chem 288(48):34943-55. PubMed: 24142695MGI: J:204967
- Bigsby RM; Caperell-Grant A. 2011. The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorigenesis. Carcinogenesis 32(8):1162-6. PubMed: 21606321MGI: J:174984
- Binart N; Helloco C; Ormandy CJ; Barra J; Clement-Lacroix P; Baran N; Kelly PA. 2000. Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration. Endocrinology 141(7):2691-7. PubMed: 10875275MGI: J:115329
- Binart N; Imbert-Bollore P; Baran N; Viglietta C; Kelly PA. 2003. A short form of the prolactin (PRL) receptor is able to rescue mammopoiesis in heterozygous PRL receptor mice. Mol Endocrinol 17(6):1066-74. PubMed: 12624115MGI: J:83628
- Binart N; Melaine N; Pineau C; Kercret H; Touzalin AM; Imbert-Bollore P; Kelly PA; Jegou B. 2003. Male reproductive function is not affected in prolactin receptor-deficient mice. Endocrinology 144(9):3779-82. PubMed: 12933648MGI: J:85593
- Bouchard B; Ormandy CJ; Di Santo JP; Kelly PA. 1999. Immune system development and function in prolactin receptor-deficient mice. J Immunol 163(2):576-82. PubMed: 10395643MGI: J:56163
- Brisken C; Kaur S; Chavarria TE; Binart N; Sutherland RL; Weinberg RA; Kelly PA; Ormandy CJ. 1999. Prolactin controls mammary gland development via direct and indirect mechanisms. Dev Biol 210(1):96-106. PubMed: 10364430MGI: J:55578
- Brouwers B; de Faudeur G; Osipovich AB; Goyvaerts L; Lemaire K; Boesmans L; Cauwelier EJ; Granvik M; Pruniau VP; Van Lommel L; Van Schoors J; Stancill JS; Smolders I; Goffin V; Binart N; In't Veld P; Declercq J; Magnuson MA; Creemers JW; Schuit F; Schraenen A. 2014. Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression. Cell Metab 20(6):979-90. PubMed: 25470546MGI: J:215816
- Brown RS; Wyatt AK; Herbison RE; Knowles PJ; Ladyman SR; Binart N; Banks WA; Grattan DR. 2016. Prolactin transport into mouse brain is independent of prolactin receptor. FASEB J 30(2):1002-10. PubMed: 26567005MGI: J:235234
- Carre N; Solomon G; Gertler A; Binart N. 2014. Effects of high affinity leptin antagonist on prolactin receptor deficient male mouse. PLoS One 9(3):e91422. PubMed: 24667351MGI: J:215057
- Chen CC; Stairs DB; Boxer RB; Belka GK; Horseman ND; Alvarez JV; Chodosh LA. 2012. Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes Dev 26(19):2154-68. PubMed: 23028142MGI: J:188260
- Clement-Lacroix P; Ormandy C; Lepescheux L; Ammann P; Damotte D; Goffin V; Bouchard B; Amling M; Gaillard-Kelly M; Binart N; Baron R; Kelly PA. 1999. Osteoblasts are a new target for prolactin: analysis of bone formation in prolactin receptor knockout mice. Endocrinology 140(1):96-105. PubMed: 9886812MGI: J:52026
- Costanza M; Musio S; Abou-Hamdan M; Binart N; Pedotti R. 2013. Prolactin is not required for the development of severe chronic experimental autoimmune encephalomyelitis. J Immunol 191(5):2082-8. PubMed: 23885109MGI: J:205822
- Craven AJ; Nixon AJ; Ashby MG; Ormandy CJ; Blazek K; Wilkins RJ; Pearson AJ. 2006. Prolactin delays hair regrowth in mice. J Endocrinol 191(2):415-25. PubMed: 17088411MGI: J:114701
- Craven AJ; Ormandy CJ; Robertson FG; Wilkins RJ; Kelly PA; Nixon AJ; Pearson AJ. 2001. Prolactin signaling influences the timing mechanism of the hair follicle: analysis of hair growth cycles in prolactin receptor knockout mice. Endocrinology 142(6):2533-9. PubMed: 11356702MGI: J:70207
- Devi YS; Shehu A; Stocco C; Halperin J; Le J; Seibold AM; Lahav M; Binart N; Gibori G. 2009. Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor. Endocrinology 150(7):3327-35. PubMed: 19342455MGI: J:151799
- Ferraris J; Zarate S; Jaita G; Boutillon F; Bernadet M; Auffret J; Seilicovich A; Binart N; Goffin V; Pisera D. 2014. Prolactin induces apoptosis of lactotropes in female rodents. PLoS One 9(5):e97383. PubMed: 24859278MGI: J:216313
- Fleenor D; Oden J; Kelly PA; Mohan S; Alliouachene S; Pende M; Wentz S; Kerr J; Freemark M. 2005. Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency. Endocrinology 146(1):103-12. PubMed: 15388648MGI: J:95779
- Flint DJ; Binart N; Boumard S; Kopchick JJ; Kelly P. 2006. Developmental aspects of adipose tissue in GH receptor and prolactin receptor gene disrupted mice: site-specific effects upon proliferation, differentiation and hormone sensitivity. J Endocrinol 191(1):101-11. PubMed: 17065393MGI: J:114956
- Freemark M; Avril I; Fleenor D; Driscoll P; Petro A; Opara E; Kendall W; Oden J; Bridges S; Binart N; Breant B; Kelly PA. 2002. Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance. Endocrinology 143(4):1378-85. PubMed: 11897695MGI: J:106829
- Freemark M; Fleenor D; Driscoll P; Binart N; Kelly P. 2001. Body weight and fat deposition in prolactin receptor-deficient mice. Endocrinology 142(2):532-7. PubMed: 11159821MGI: J:67354
- Gallego MI; Binart N; Robinson GW; Okagaki R; Coschigano KT; Perry J; Kopchick JJ; Oka T; Kelly PA; Hennighausen L. 2001. Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev Biol 229(1):163-75. PubMed: 11133161MGI: J:66900
- Goyvaerts L; Lemaire K; Arijs I; Auffret J; Granvik M; Van Lommel L; Binart N; in't Veld P; Schuit F; Schraenen A. 2015. Prolactin receptors and placental lactogen drive male mouse pancreatic islets to pregnancy-related mRNA changes. PLoS One 10(3):e0121868. PubMed: 25816302MGI: J:229617
- Grimm SL; Seagroves TN; Kabotyanski EB; Hovey RC; Vonderhaar BK; Lydon JP; Miyoshi K; Hennighausen L; Ormandy CJ; Lee AV; Stull MA; Wood TL; Rosen JM. 2002. Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. Mol Endocrinol 16(12):2675-91. PubMed: 12456789MGI: J:125450
- Grosdemouge I; Bachelot A; Lucas A; Baran N; Kelly PA; Binart N. 2003. Effects of deletion of the prolactin receptor on ovarian gene expression. Reprod Biol Endocrinol 1:12. PubMed: 12646063MGI: J:102442
- Halperin J; Devi SY; Elizur S; Stocco C; Shehu A; Rebourcet D; Unterman TG; Leslie ND; Le J; Binart N; Gibori G. 2008. Prolactin Signaling through the Short Form of Its Receptor Represses Forkhead Transcription Factor FOXO3 and Its Target Gene Galt Causing a Severe Ovarian Defect. Mol Endocrinol 22(2):513-22. PubMed: 17975019MGI: J:130265
- Harris J; Stanford PM; Sutherland K; Oakes SR; Naylor MJ; Robertson FG; Blazek KD; Kazlauskas M; Hilton HN; Wittlin S; Alexander WS; Lindeman GJ; Visvader JE; Ormandy CJ. 2006. Socs2 and elf5 mediate prolactin-induced mammary gland development. Mol Endocrinol 20(5):1177-87. PubMed: 16469767MGI: J:108377
- Hilton HN; Stanford PM; Harris J; Oakes SR; Kaplan W; Daly RJ; Ormandy CJ. 2008. KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. Biochim Biophys Acta 1783(3):383-93. PubMed: 18190796MGI: J:133423
- Huang C. 2013. Wild-type offspring of heterozygous prolactin receptor-null female mice have maladaptive beta-cell responses during pregnancy. J Physiol 591(Pt 5):1325-38. PubMed: 23247113MGI: J:207359
- Huang C; Snider F; Cross JC. 2009. Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy. Endocrinology 150(4):1618-26. PubMed: 19036882MGI: J:158082
- Hughes E; Huang C. 2011. Participation of Akt, menin, and p21 in pregnancy-induced beta-cell proliferation. Endocrinology 152(3):847-55. PubMed: 21239436MGI: J:173881
- Kedzia C; Lacroix L; Ameur N; Ragot T; Kelly PA; Caillou B; Binart N. 2005. Medullary thyroid carcinoma arises in the absence of prolactin signaling. Cancer Res 65(18):8497-503. PubMed: 16166330MGI: J:101609
- Le Provost F; Miyoshi K; Vilotte JL; Bierie B; Robinson GW; Hennighausen L. 2005. SOCS3 promotes apoptosis of mammary differentiated cells. Biochem Biophys Res Commun 338(4):1696-701. PubMed: 16289036MGI: J:104012
- Lindeman GJ; Wittlin S; Lada H; Naylor MJ; Santamaria M; Zhang JG; Starr R; Hilton DJ; Alexander WS; Ormandy CJ; Visvader J. 2001. SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice. Genes Dev 15(13):1631-6. PubMed: 11445538MGI: J:70408
- Long W; Wagner KU; Lloyd KC; Binart N; Shillingford JM; Hennighausen L; Jones FE. 2003. Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development 130(21):5257-68. PubMed: 12954715MGI: J:86319
- Lucas BK; Ormandy CJ; Binart N; Bridges RS; Kelly PA. 1998. Null mutation of the prolactin receptor gene produces a defect in maternal behavior. Endocrinology 139(10):4102-7. PubMed: 9751488MGI: J:83247
- Mak GK; Enwere EK; Gregg C; Pakarainen T; Poutanen M; Huhtaniemi I; Weiss S. 2007. Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior. Nat Neurosci 10(8):1003-11. PubMed: 17603480MGI: J:124216
- Mak GK; Weiss S. 2010. Paternal recognition of adult offspring mediated by newly generated CNS neurons. Nat Neurosci 13(6):753-8. PubMed: 20453850MGI: J:161454
- McClellan KA; Robertson FG; Kindblom J; Wennbo H; Tornell J; Bouchard B; Kelly PA; Ormandy CJ. 2001. Investigation of the role of prolactin in the development and function of the lacrimal and harderian glands using genetically modified mice Invest Ophthalmol Vis Sci 42(1):23-30. PubMed: 11133844MGI: J:66544
- Moreno-Carranza B; Goya-Arce M; Vega C; Adan N; Triebel J; Lopez-Barrera F; Quintanar-Stephano A; Binart N; Martinez de la Escalera G; Clapp C. 2013. Prolactin promotes normal liver growth, survival, and regeneration in rodents: effects on hepatic IL-6, suppressor of cytokine signaling-3, and angiogenesis. Am J Physiol Regul Integr Comp Physiol 305(7):R720-6. PubMed: 23948778MGI: J:201594
- Nilsson L; Binart N; Bohlooly-Y M; Bramnert M; Egecioglu E; Kindblom J; Kelly PA; Kopchick JJ; Ormandy CJ; Ling C; Billig H. 2005. Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue. Biochem Biophys Res Commun 331(4):1120-6. PubMed: 15882993MGI: J:98282
- Oakes SR; Robertson FG; Kench JG; Gardiner-Garden M; Wand MP; Green JE; Ormandy CJ. 2007. Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions. Oncogene 26(4):543-53. PubMed: 16862169MGI: J:117839
- Pasek RC; Gannon M. 2013. Advancements and challenges in generating accurate animal models of gestational diabetes mellitus. Am J Physiol Endocrinol Metab 305(11):E1327-38. PubMed: 24085033MGI: J:204991
- Patil MJ; Green DP; Henry MA; Akopian AN. 2013. Sex-dependent roles of prolactin and prolactin receptor in postoperative pain and hyperalgesia in mice. Neuroscience 253:132-41. PubMed: 23994182MGI: J:207435
- Patil MJ; Ruparel SB; Henry MA; Akopian AN. 2013. Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in a sex-dependent manner: Contribution of prolactin receptor to inflammatory pain. Am J Physiol Endocrinol Metab 305(9):E1154-64. PubMed: 24022869MGI: J:204510
- Rawn SM; Huang C; Hughes M; Shaykhutdinov R; Vogel HJ; Cross JC. 2015. Pregnancy Hyperglycemia in Prolactin Receptor Mutant, but Not Prolactin Mutant, Mice and Feeding-Responsive Regulation of Placental Lactogen Genes Implies Placental Control of Maternal Glucose Homeostasis. Biol Reprod 93(3):75. PubMed: 26269505MGI: J:226254
- Reese J; Binart N; Brown N; Ma WG; Paria BC; Das SK; Kelly PA; Dey SK. 2000. Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR. Endocrinology 141(5):1872-81. PubMed: 10803598MGI: J:61911
- Riedlinger G; Okagaki R; Wagner KU; Rucker EB 3rd; Oka T; Miyoshi K; Flaws JA; Hennighausen L. 2002. Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary. Biol Reprod 66(2):438-44. PubMed: 11804960MGI: J:108582
- Robertson FG; Harris J; Naylor MJ; Oakes SR; Kindblom J; Dillner K; Wennbo H; Tornell J; Kelly PA; Green J; Ormandy CJ. 2003. Prostate development and carcinogenesis in prolactin receptor knockout mice. Endocrinology 144(7):3196-205. PubMed: 12810576MGI: J:84352
- Schuff KG; Hentges ST; Kelly MA; Binart N; Kelly PA; Iuvone PM; Asa SL; Low MJ. 2002. Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms. J Clin Invest 110(7):973-81. PubMed: 12370275MGI: J:79683
- Shingo T; Gregg C; Enwere E; Fujikawa H; Hassam R; Geary C; Cross JC; Weiss S. 2003. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science 299(5603):117-20. PubMed: 12511652MGI: J:83248
- Viengchareun S; Servel N; Feve B; Freemark M; Lombes M; Binart N. 2008. Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2. PLoS One 3(2):e1535. PubMed: 18253483MGI: J:132155
- Zhou J; Chehab R; Tkalcevic J; Naylor MJ; Harris J; Wilson TJ; Tsao S; Tellis I; Zavarsek S; Xu D; Lapinskas EJ; Visvader J; Lindeman GJ; Thomas R; Ormandy CJ; Hertzog PJ; Kola I; Pritchard MA. 2005. Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. EMBO J 24(3):635-44. PubMed: 15650748MGI: J:96237