hematopoietic system phenotype

• absent spleen germinal center
  • in homozygous null mice, splenic white pulp is devoid of germinal centers
  (MGI Ref ID J:38092)

immune system phenotype

• absent spleen germinal center
  • in homozygous null mice, splenic white pulp is devoid of germinal centers
  (MGI Ref ID J:38092)

• increased susceptibility to bacterial infection
  • relative to wild-type, homozygous null mice display a highly increased susceptibility to infection with Streptococcus pneumoniae: their blood smears indicate sepsis and mutants never survive longer than 2 days, irrespective of dosage level
  (MGI Ref ID J:38092)
  • also, homozygotes are unable to clear Listeria monocytogenes as effectively as wild-type
  (MGI Ref ID J:38092)

• abnormal humoral immune response
  • however, following immunization with Streptococcus pneumoniae, homozygotes fail to produce antigen-specific antibodies
  (MGI Ref ID J:38092)
  • naive homozygotes exhibit normal levels of resting immunoglobulins
  (MGI Ref ID J:38092)

mammalian phenotype

• immune system phenotype
  • Normal - homozygotes are viable and grossly normal, and produce normal numbers of mature B- and T-cell subsets
  (MGI Ref ID J:38092)