Mice homozygous (females) or hemizygous (males) for the X-linked Grprtm1Jfb targeted mutation are viable with no gross phenotypic abnormalities observed. There is a deficiency in bombesin-induced mediation of satiety as measured by glucose intake. A modest increase in body weight is observed in older animals. At 18-20 months of age, hemizygous males (N = 8) are 44.5g &plusmn; 5.1 (mean &plusmn; std dev) and wildtype littermates (N = 8) are 38.3g &plusmn; 5.1 (L. Hampton, unpublished observation). 
 2000: We observed head tilts and bobbing in the hemizygous males in our production colony. The donating investigator of this strain has also observed this phenotype and considers it a mutation not related to the gene. We will monitor for that phenotype and avoid breeding/cryopreserving animals displaying it, but it is possible an unknown recessive mutation causing that phenotype may remain.

These Grpr knock-out mice exhibit elevation of body weight in older animals associated with a deficiency in bombesin-induced mediation of satiety.

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