Mice homozygous (females) or hemizygous (males) for the X-linked Grprtm1Jfb targeted mutation are viable with no gross phenotypic abnormalities observed. There is a deficiency in bombesin-induced mediation of satiety as measured by glucose intake. A modest increase in body weight is observed in older animals. At 18-20 months of age, hemizygous males (N = 8) are 44.5g &plusmn; 5.1 (mean &plusmn; std dev) and wildtype littermates (N = 8) are 38.3g &plusmn; 5.1 (L. Hampton, unpublished observation). We have recently observed head tilts and bobbing in the hemizygous males in our production colony. The donating investigator of this strain has also observed this phenotype and considers it a mutation not related to the gene. We are working to remove this phenotype, but we will continue to ship from the colony while we finish this process.

These Grpr knock-out mice exhibit elevation of body weight in older animals associated with a deficiency in bombesin-induced mediation of satiety.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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