JAX Mouse Strain Datasheet - 003069

B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ

Stock No:: 003069 |; B6.NOD Idd1,5 (c1c)

Congenic

Cryo Recovery

Overview

Also Known As: B6.NOD Idd1,5 (c1c)

These doubly congenic mice carry two chromosomal segments, one bound by an Mit marker and B-cell leukemia/lymphoma 2 (Bcl2) and the other by Mit markers. One segment from Chromosome 17 includes the major histocompatibility complex (H2) and the insulin dependent diabetes susceptibility locus 1 (Idd1), and the other segment from Chromosome 1 contains the insulin dependent diabetes susceptibility locus 5 (Idd5).

Donating Investigator

Dr. Edward Leiter, The Jackson Laboratory

Genetic overview

Genetic Background	Generation
C57BL/6

H2^g7

Allele Type	Gene Symbol	Gene Name
Not Applicable	H2	histocompatibility-2, MHC

Idd1^NOD/Uf

Allele Type	Gene Symbol	Gene Name
QTL	Idd1	insulin dependent diabetes susceptibility 1

Idd5^NOD

Allele Type	Gene Symbol	Gene Name
QTL	Idd5	insulin dependent diabetes susceptibility 5

Marker(s)

	Marker Symbol	Marker Name
	Bcl2	B cell leukemia/lymphoma 2
	D17Mit10	DNA segment, Chr 17, Massachusetts Institute of Technology 10
	D17Mit21	DNA segment, Chr 17, Massachusetts Institute of Technology 21
	D1Mit3	DNA segment, Chr 1, Massachusetts Institute of Technology 3

View Genetics

Research Applications

Immunology, Inflammation and Autoimmunity Research
Diabetes and Obesity Research

View All Research Applications

Base Price

Starting at:

$2,625.00 Domestic price Cryo Recovery

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Details

Detailed Description

This strain is doubly congenic for a 19 cM segment of Chr 17 (called c17 in the reference below) extending from D17Mit21 through D17Mit10 and including the major histocompatibility complex, H2, and the insulin dependent diabetes susceptibility locus Idd1 and for a 44 cM segment of Chr 1 (called c1c by Yui et al.) extending from D1Mit3 through Bcl2 (B-cell leukemia/lymphoma 2) and including Idd5(insulin dependent diabetes susceptibility 5). No information has been published for this double congenic. However, upon histologic examination of the pancreas, a significantly higher percentage of both B6.NOD-D1Mit3-Bcl2 (Idd5) and B6.NOD-D17Mit21-D17Mit10 (H2^g7, Idd1) singly congenic mice than of C57BL/6J control mice were found to exhibit periinsulitis, and more extensive mononuclear cell infiltrates were observed in the pancreas of these mice. The pancreatic infiltrates were not associated specifically with the islets. Insulitis (intraislet infiltration) was extremely rare, and no more than one affected islet was observed in a single animal, even in cases where extensive perivascular/periductal infiltrates existed. Although male and female B6.NOD-D17Mit21-D17Mit10 (H2^g7, Idd1) mice exhibited similar incidence of pancreatic infiltration, B6.NOD-D1Mit3-Bcl2 (Idd5) females developed periinsulitis at twice the frequency of males. Female NOD mice are more susceptible than males to both insulitis and diabetes.

Development

Genomic segments found in earlier linkage studies to include diabetogenic loci were transferred from NOD/Uf to C57BL/6 by six successive backcrosses (to N7). Sibs of each lineage were then intercrossed to generate homozygotes for each segment. Microsatellite analysis was used to type mice for loci in the regions of interest. As evidence suggested the existence of multiple loci on Chr 1 that affect susceptibility to IDD and/or insulitis, two congenic lines were generated carrying overlapping segments of Chr 1, each including the diabetes susceptibility locus and one insulitis susceptibility locus. The B6.NOD-D1Mit3-Bcl2 D17Mit21-D17Mit10 (Idd5; H2^g7 , Idd1) double congenic strain was created by crossing mice of the singly congenic B6.NOD-D17Mit21-D17Mit10 (H2^g7 , Idd1) and B6.NOD-D1Mit3-Bcl2 (Idd5) strains, then breeding to homozygosity for both congenic segments.

Genetics

H2^g7

Allele Symbol: H2^g7

Allele Name	g7 variant
Allele Type	Not Applicable
Allele Synonym(s)
Gene Symbol and Name	H2, histocompatibility-2, MHC
Gene Synonym(s)	H-2; H-2; MHC-II
Strain of Origin	Not Applicable
Chromosome	17
General Note	The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2^g7

Idd1^NOD/Uf

Allele Symbol: Idd1^NOD/Uf

Allele Name	NOD/Uf
Allele Type	QTL
Allele Synonym(s)
Gene Symbol and Name	Idd1, insulin dependent diabetes susceptibility 1
Gene Synonym(s)	Idd-1; Idd-1
Strain of Origin	NOD/Uf
Chromosome	17
General Note	NOD is homozygous for recessive alleles for susceptibility at all three loci, Idd1^s, Idd2^s, and Idd3^s. The dominant alleles for non-susceptibility to IDD, Idd1^r, etc., occur in the NON strain. Homozygosity for the recessive alleles at all three loci is necessary for the development of IDD.The Idd1 locus is linked to the major histocompatibility locus on Chr 17, but Idd2 is on Chr 9 (1) and Idd3 is on Chr 3 (J:8783, J:3351). This locus is also linked to peripheral CD4 lymphocytosis.
Molecular Note	This allele confers increased periinsulitis and increased CD4 lymphocytosis compared to C57BL/6.

Idd5^NOD

Allele Symbol: Idd5^NOD

Allele Name	NOD
Allele Type	QTL
Allele Synonym(s)
Gene Symbol and Name	Idd5, insulin dependent diabetes susceptibility 5
Gene Synonym(s)	Idd-5; Idd-5
Strain of Origin	NOD
Chromosome	1
Molecular Note	This allele confers susceptibility to insulin dependent diabetes compared to C57BL/10.

Bcl2

Marker Symbol: Bcl2

Marker Synonym(s)	AW986256; Bcl-2; Bcl-2; C430015F12Rik; C430015F12Rik; D630044D05Rik; D830018M01Rik; D830018M01Rik; PPP1R50; RIKEN cDNA C430015F12 gene; RIKEN cDNA D630044D05 gene; RIKEN cDNA D830018M01 gene; expressed sequence AW986256
Chromosome(s)	1

D17Mit10

Marker Symbol: D17Mit10

Marker Synonym(s)
Chromosome(s)	17

D17Mit21

Marker Symbol: D17Mit21

Marker Synonym(s)
Chromosome(s)	17

D1Mit3

Marker Symbol: D1Mit3

Marker Synonym(s)
Chromosome(s)	1

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
- Autoimmunity

Genotype: H2^g7 related

Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers

Genotype: Idd5^NOD related

Diabetes and Obesity Research
- Type 1 Diabetes (IDDM) Analysis Strains
  - NOD/ShiLtJ MHC Congenics
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
- CD Antigens, Antigen Receptors, and Histocompatibility Markers

References

Additional References

Lamhamedi-Cherradi SE; Boulard O; Gonzalez C; Kassis N; Damotte D; Eloy L; Fluteau G; Levi-Strauss M; Garchon HJ. 2001. Further Mapping of the Idd5.1 Locus for Autoimmune Diabetes in NOD Mice. Diabetes 50(12):2874-8. PubMed: 11723074 MGI: J:72900
Yui MA; Muralidharan K; Moreno-Altamirano B; Perrin G; Chestnut K; Wakeland EK. 1996. Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mamm Genome 7(5):331-4. PubMed: 8661724 MGI: J:33172

Additional - H2^g7 related

Auger JL; Haasken S; Steinert EM; Binstadt BA. 2012. Incomplete TCR-beta allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice. Eur J Immunol 42(9):2354-62. PubMed: 22706882 MGI: J:187944
Bassi EJ; Moraes-Vieira PM; Moreira-Sa CS; Almeida DC; Vieira LM; Cunha CS; Hiyane MI; Basso AS; Pacheco-Silva A; Camara NO. 2012. Immune regulatory properties of allogeneic adipose-derived mesenchymal stem cells in the treatment of experimental autoimmune diabetes. Diabetes 61(10):2534-45. PubMed: 22688334 MGI: J:208536
Belizaire R; Unanue ER. 2009. Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation. Proc Natl Acad Sci U S A 106(41):17463-8. PubMed: 19805168 MGI: J:153672
Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. PubMed: 19805369 MGI: J:153217
Carrasco-Marin E; Shimizu J; Kanagawa O; Unanue ER. 1996. The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. J Immunol 156(2):450-8. PubMed: 8543793 MGI: J:30538
Choisy-Rossi CM; Holl TM; Pierce MA; Chapman HD; Serreze DV. 2004. Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience. J Immunol 173(6):3791-800. PubMed: 15356126 MGI: J:167508
Driver JP; Chen YG; Zhang W; Asrat S; Serreze DV. 2011. Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses. Diabetes 60(4):1354-9. PubMed: 21307079 MGI: J:171763
Driver JP; Scheuplein F; Chen YG; Grier AE; Wilson SB; Serreze DV. 2010. Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. Diabetes 59(2):423-32. PubMed: 19903740 MGI: J:164162
Ferreira C; Singh Y; Furmanski AL; Wong FS; Garden OA; Dyson J. 2009. Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells. Proc Natl Acad Sci U S A 106(20):8320-5. PubMed: 19359477 MGI: J:148537
Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J Exp Med 190(4):577-83. PubMed: 10449528 MGI: J:108724
Fousteri G; Jasinski J; Dave A; Nakayama M; Pagni P; Lambolez F; Juntti T; Sarikonda G; Cheng Y; Croft M; Cheroutre H; Eisenbarth G; von Herrath M. 2012. Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice. Diabetes 61(5):1169-79. PubMed: 22403296 MGI: J:196727
Gray D; Abramson J; Benoist C; Mathis D. 2007. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 204(11):2521-8. PubMed: 17908938 MGI: J:126040
Haasken S; Auger JL; Taylor JJ; Hobday PM; Goudy BD; Titcombe PJ; Mueller DL; Binstadt BA. 2013. Macrophage scavenger receptor 1 (Msr1, SR-A) influences B cell autoimmunity by regulating soluble autoantigen concentration. J Immunol 191(3):1055-62. PubMed: 23794629 MGI: J:205440
Jasinski JM; Yu L; Nakayama M; Li MM; Lipes MA; Eisenbarth GS; Liu E. 2006. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes 55(7):1978-84. PubMed: 16804066 MGI: J:111874
Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. PubMed: 6407984 MGI: J:7097
Kouskoff V; Korganow AS; Duchatelle V; Degott C; Benoist C; Mathis D. 1996. Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-22. PubMed: 8945509 MGI: J:36815
Lee JS; Scandiuzzi L; Ray A; Wei J; Hofmeyer KA; Abadi YM; Loke P; Lin J; Yuan J; Serreze DV; Allison JP; Zang X. 2012. B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells. J Immunol 189(8):4165-74. PubMed: 22972920 MGI: J:190522
Lee MS; Mueller R; Wicker LS; Peterson LB; Sarvetnick N. 1996. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J Exp Med 183(6):2663-8. PubMed: 8676087 MGI: J:153576
Leiter EH. 1998. NOD Mice and Related Strains: Origins, Husbandry and Biology Introduction. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer, and Other Diseases. RG Landes, Austin. MGI: J:110093
Levisetti MG; Lewis DM; Suri A; Unanue ER. 2008. Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice. Diabetes 57(7):1852-60. PubMed: 18398138 MGI: J:138230
Luhder F; Katz J; Benoist C; Mathis D. 1998. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J Exp Med 187(3):379-87. PubMed: 9449718 MGI: J:108722
Ma YD; Park C; Zhao H; Oduro KA Jr; Tu X; Long F; Allen PM; Teitelbaum SL; Choi K. 2009. Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model. Blood 114(20):4402-10. PubMed: 19759358 MGI: J:154922
Mahler M; Bristol IJ; Leiter EH; Workman AE; Birkenmeier EH; Elson CO; Sundberg JP. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol 274(3 Pt 1):G544-51. PubMed: 9530156 MGI: J:46553
Mangada J; Pearson T; Brehm MA; Wicker LS; Peterson LB; Shultz LD; Serreze DV; Rossini AA; Greiner DL. 2009. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes 58(1):165-73. PubMed: 18984741 MGI: J:146982
Martin-Orozco N; Chen Z; Poirot L; Hyatt E; Chen A; Kanagawa O; Sharpe A; Mathis D; Benoist C. 2003. Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. J Immunol 171(12):6954-60. PubMed: 14662903 MGI: J:86926
Martinez RJ; Zhang N; Thomas SR; Nandiwada SL; Jenkins MK; Binstadt BA; Mueller DL. 2012. Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells. J Immunol 188(1):170-81. PubMed: 22124124 MGI: J:180819
Pearson T; Markees TG; Serreze DV; Pierce MA; Marron MP; Wicker LS; Peterson LB; Shultz LD; Mordes JP; Rossini AA; Greiner DL. 2003. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol 171(1):185-95. PubMed: 12816997 MGI: J:109845
Perera J; Meng L; Meng F; Huang H. 2013. Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection. Proc Natl Acad Sci U S A 110(42):17011-6. PubMed: 24082098 MGI: J:202000
Podolin PL; Pressey A; DeLarato NH; Fischer PA; Peterson LB; Wicker LS. 1993. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178(3):793-803. PubMed: 8350054 MGI: J:14178
Rajasekaran N; Wang N; Hang Y; Macaubas C; Rinderknecht C; Beilhack GF; Shizuru JA; Mellins ED. 2013. B6.g7 mice reconstituted with BDC2.5 non-obese diabetic (BDC2.5NOD) stem cells do not develop autoimmune diabetes. Clin Exp Immunol 174(1):27-37. PubMed: 23795893 MGI: J:200611
Serreze DV; Gallichan WS; Snider DP; Croitoru K; Rosenthal KL; Leiter EH; Christianson GJ; Dudley ME; Roopenian DC. 1996. MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice. Diabetes 45(7):902-8. PubMed: 8666141 MGI: J:33688
Suwanai H; Wilcox MA; Mathis D; Benoist C. 2010. A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice. Proc Natl Acad Sci U S A 107(20):9305-10. PubMed: 20439722 MGI: J:160284
Taylor JJ; Martinez RJ; Titcombe PJ; Barsness LO; Thomas SR; Zhang N; Katzman SD; Jenkins MK; Mueller DL. 2012. Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. J Exp Med 209(11):2065-77. PubMed: 23071255 MGI: J:190897
Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. PubMed: 16317068 MGI: J:104385
Victoratos P; Kollias G. 2009. Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells. Immunity 30(1):130-42. PubMed: 19119026 MGI: J:143728
Wang JX; Bair AM; King SL; Shnayder R; Huang YF; Shieh CC; Soberman RJ; Fuhlbrigge RC; Nigrovic PA. 2012. Ly6G ligation blocks recruitment of neutrophils via a beta2-integrin-dependent mechanism. Blood 120(7):1489-98. PubMed: 22661700 MGI: J:189105
Wei J; Loke P; Zang X; Allison JP. 2011. Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity. J Exp Med 208(8):1683-94. PubMed: 21727190 MGI: J:177612
Wong FS; Du W; Thomas IJ; Wen L. 2005. The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice. Diabetes 54(7):2032-40. PubMed: 15983204 MGI: J:109830
Yoshida T; Jiang F; Honjo T; Okazaki T. 2008. PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice. Proc Natl Acad Sci U S A 105(9):3533-8. PubMed: 18299579 MGI: J:132764
Zhang C; Todorov I; Lin CL; Atkinson M; Kandeel F; Forman S; Zeng D. 2007. Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice. Proc Natl Acad Sci U S A 104(7):2337-42. PubMed: 17267595 MGI: J:119749

Additional - Idd1^NOD/Uf related

Koarada S; Wu Y; Yim YS; Wakeland EW; Ridgway WM. 2004. Nonobese diabetic CD4 lymphocytosis maps outside the MHC locus on chromosome 17. Immunogenetics 56(5):333-7. PubMed: 15309345 MGI: J:92304
Prochazka M; Leiter EH; Serreze DV; Coleman DL. 1987. Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice [published erratum appears in Science 1988 Nov 11;242(4880):945] Science 237(4812):286-9. PubMed: 2885918 MGI: J:8783
Todd JA; Aitman TJ; Cornall RJ; Ghosh S; Hall JR; Hearne CM; Knight AM; Love JM; McAleer MA; Prins JB; Rodrigues N; Lathrop M; Pressey A; DeLarato NH; Peterson LB; Wicker LS. 1991. Genetic analysis of autoimmune type 1 diabetes mellitus in mice [see comments] Nature 351(6327):542-7. PubMed: 1675432 MGI: J:3351
Yui MA; Muralidharan K; Moreno-Altamirano B; Perrin G; Chestnut K; Wakeland EK. 1996. Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mamm Genome 7(5):331-4. PubMed: 8661724 MGI: J:33172

Additional - Idd5^NOD related

Brayer J; Lowry J; Cha S; Robinson CP; Yamachika S; Peck AB; Humphreys-Beher MG. 2000. Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjogren's syndrome-like autoimmune exocrinopathy. J Rheumatol 27(8):1896-904. PubMed: 10955330 MGI: J:71276
Cornall RJ. 1993. Genetics of a multifactorial disease: autoimmune type 1 diabetes mellitus. Clin Sci (Colch) 84(3):257-62. PubMed: 8384947 MGI: J:17906
Motta V; Lejon K; Holmberg D. 2007. The NOD allele of the Idd5 locus on chromosome 1 mediates a non-cell-autonomous defect in negative selection of T cells. J Autoimmun 28(4):216-23. PubMed: 17449224 MGI: J:125098
Nguyen CQ; Kim H; Cornelius JG; Peck AB. 2007. Development of Sjogren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3. J Immunol 179(4):2318-29. PubMed: 17675493 MGI: J:151221
Nguyen CQ; Sharma A; She JX; McIndoe RA; Peck AB. 2009. Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjogren's syndrome (SJS)-like disease of the C57BL/6.NOD-Aec1Aec2 mouse. Exp Eye Res 88(3):398-409. PubMed: 19103199 MGI: J:146559
Nguyen CQ; Yin H; Lee BH; Chiorini JA; Peck AB. 2011. IL17: potential therapeutic target in Sjogren's syndrome using adenovirus-mediated gene transfer. Lab Invest 91(1):54-62. PubMed: 20856230 MGI: J:167186

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Also Known As: B6.NOD Idd1,5 (c1c)

Donating Investigator

Genetic overview

Marker(s)

Research Applications

Base Price

Detailed Description

Development

H2g7

Allele Symbol: H2g7

Idd1NOD/Uf

Allele Symbol: Idd1NOD/Uf

Idd5NOD

Allele Symbol: Idd5NOD

Bcl2

Marker Symbol: Bcl2

D17Mit10

Marker Symbol: D17Mit10

D17Mit21

Marker Symbol: D17Mit21

D1Mit3

Marker Symbol: D1Mit3

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: H2g7 related

Genotype: Idd5NOD related

References

Additional References

Additional - H2g7 related

Additional - Idd1NOD/Uf related

Additional - Idd5NOD related

Genotyping Protocols

Breeding Considerations

Appearance

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Progeny testing is not required

RELATED PRODUCTS AND SERVICES

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

H2^g7

Allele Symbol: H2^g7

Idd1^NOD/Uf

Allele Symbol: Idd1^NOD/Uf

Idd5^NOD

Allele Symbol: Idd5^NOD

Genotype: H2^g7 related

Genotype: Idd5^NOD related

Additional - H2^g7 related

Additional - Idd1^NOD/Uf related

Additional - Idd5^NOD related