These congenic mice carry a chromosomal segment from Chromosome 1 bounded by an Mit marker and B-cell leukemia/lymphoma 2 (Bcl2) and includes the insulin dependent diabetes susceptibility locus 5 (Idd5).
This strain is congenic for a 44 cM segment of Chr 1 extending from D1Mit3 through Bcl2 (B-cell leukemia/lymphoma 2) that includes Idd5 (insulin dependent diabetes susceptibility 5). The name given this segment in the primary reference is c1c. Upon histologic examination of the pancreas, a significantly higher percentage of B6.NOD-(D1Mit3-Bcl2) congenic mice than of C57BL/6J control mice were found to exhibit periinsulitis, and more extensive mononuclear cell infiltrates were observed in the pancreata of these mice. The pancreatic infiltrates were not associated specifically with the islets. Insulitis (intraislet infiltration) was extremely rare, and no more than one affected islet was observed in a single animal, even in cases where extensive perivascular/periductal infiltrates existed. Female B6.NOD-(D1Mit3-Bcl2) mice exhibited pancreatic infiltration at twice the frequency of males; female NOD mice are more susceptible than males to both insulitis and diabetes.
Genomic segments found in earlier linkage studies to include diabetogenic loci were transferred in the laboratory of E.K. Wakeland from NOD/Uf to C57BL/6 by six successive backcrosses (to N7). Sibs of each lineage were then intercrossed to generate mice homozygous for each segment. Microsatellite analysis was used to type mice for loci in the regions of interest. As evidence suggested the existence of multiple loci on Chr 1 that affect susceptibility to IDD and/or insulitis, two congenic lines were generated carrying overlapping segments of Chr 1, each including the diabetes susceptibility locus and one insulitis susceptibility locus.
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