ABP.EL-El1^EL/FrkJ

Stock number: 003015
Product name: El-1

Detailed description

Mice from this congenic strain carry the El1^EL quantitative trait locus (QTL) from the EL/SuzSeyFrk strain and are characterized by a susceptibility to seizures.

Development

ABP/LeJ females at inbred generation F102 were crossed with EL/SuzSeyFrk males at inbred generation F76 or beyond. Their offspring were backcrossed repeatedly to ABP/LeJ selecting breeders at each generation that carried the EL/SuzSeyFrk derived El1 interval, defined by D9Mit2, D9Mit4, D9Mit32, D9Mit35, and D9Mit16 polymorphisms. At generation N6 the heterozygous carriers were intercrossed to generate a congenic line homozygous for the EL/SuzSeyFrk derived El1 interval.

Allele

Symbol: El1^EL
Name: EL
MGI accession ID: MGI:2157558
Generation method: QTL
Marker symbol: El1
Marker name: epilepsy 1
Chromosome: 9
Strain of origin: EL
Molecular note: This allele confers susceptibility to epileptic seizures compared to ABP/LeJ and DBA/2J.
General note: The EL mouse strain was developed from mice with an increased susceptibility for epilepsy. These mice were first reported as a spontaneous mutation arising in the DDY strain. The succeptibility for epilepsy was subsequently shown to be the result of alleles at two or more loci.