Mice from this congenic strain carry the El1EL quantitative trait locus (QTL) from the EL/SuzSeyFrk strain and are characterized by a susceptibility to seizures.
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
QTL | El1 | epilepsy 1 |
Mice from this congenic strain carry the El1EL quantitative trait locus (QTL) from the EL/SuzSeyFrk strain and are characterized by a susceptibility to seizures.
ABP/LeJ females at inbred generation F102 were crossed with EL/SuzSeyFrk males at inbred generation F76 or beyond. Their offspring were backcrossed repeatedly to ABP/LeJ selecting breeders at each generation that carried the EL/SuzSeyFrk derived El1 interval, defined by D9Mit2, D9Mit4, D9Mit32, D9Mit35, and D9Mit16 polymorphisms. At generation N6 the heterozygous carriers were intercrossed to generate a congenic line homozygous for the EL/SuzSeyFrk derived El1 interval.
Allele Name | EL |
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Allele Type | QTL |
Allele Synonym(s) | EL |
Gene Symbol and Name | El1, epilepsy 1 |
Gene Synonym(s) | |
Strain of Origin | EL |
Chromosome | 9 |
General Note | The EL mouse strain was developed from mice with an increased susceptibility for epilepsy. These mice were first reported as a spontaneous mutation arising in the DDY strain. The succeptibility for epilepsy was subsequently shown to be the result of alleles at two or more loci. |
Molecular Note | This allele confers susceptibility to epileptic seizures compared to ABP/LeJ and DBA/2J. |
When using the El-1 mouse strain in a publication, please cite the originating article(s) and include JAX stock #003015 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for El1<EL>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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