JAX
Mouse Strain Datasheet - 003010
B6;CBA-Tg(Camk2a-tTA)1Mmay/J
Also Known As: CaMKII-tTA
A C57BL/6J congenic version of this strain is available as Stock No. 007004.
When these Camk2a-tTA transgenic mice are mated to strain carrying a gene of interest under the regulatory control of a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene can be blocked by administration of the tetracycline analog, doxycycline. These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's, Parkinson's disease, or other neurodegenerative diseases.
Donating Investigator
Dr. Mark Mayford, The Scripps Research Institute
Genetic overview
| Genetic Background | Generation |
|---|---|
|
F?+N3F2
|
Tg(Camk2a-tTA)1Mmay
| Allele Type |
|---|
| Transgenic (Transactivator) |
Detailed Description
Transgenic mice expressing the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain-specific calcium-calmodulin-dependent kinase II (Camk2a) promoter are viable and fertile. When hemizygotes are mated to a second strain carrying a gene of interest under the regulatory control of a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene can be blocked by administration of the tetracycline analog, doxycycline (dox). These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's disease (when used in conjunction with Stock No. 005706, Stock No. 007049, Stock No. 007051, Stock No. 007052), Parkinson's disease (Stock No. 013583), or other neurodegenerative diseases.
Of note, mice expressing Tg(Camk2a-tTA)1Mmay on the C57BL/6 background exhibit resistance to tTA-induced neurotoxicity (dentate gyrus granule cell layer atrophy). All other backgrounds tested (FVB/NJ, CBA/J, 129X1/SvJ, C3H/HeJ, DBA/1J) exhibit varying levels of neurotoxicity (Han et. al. 2012 J Neurosci 32:10574).
Development
A transgenic construct was designed with 8.5 kb of the mouse CaMKIIalpha promoter placed upstream of the tetracycline-regulated transactivator (tTA or Tet-Off) gene (flanked by an artificial intron and splice sites at the 5' end and by a polyadenylation signal from SV40 at the 3' end). Founder line B was established and maintained on a mixed B6;CBA genetic background upon its arrival at The Jackson Laboratory.
Expression Data
| Expressed Gene | tTA, tetracycline-controlled transactivator, E. coli |
|---|---|
| Site of Expression | Expresses tTA in forebrain neurons. |
Control Suggestions
Selected References
- Mayford M; Bach ME; Huang YY; Wang L; Hawkins RD; Kandel ER. 1996. Control of memory formation through regulated expression of a CaMKII transgene.. In: . . MGI: J:37107
Tg(Camk2a-tTA)1Mmay
Allele Symbol: Tg(Camk2a-tTA)1Mmay
| Allele Name | transgene insertion 1, Mark Mayford |
|---|---|
| Allele Type | Transgenic (Transactivator) |
| Allele Synonym(s) | CAMK-rTA; CaMKII-tTA; CaMKIIalpha-tTA; CamDAT; Tg(CaMKIItTA)Mmay; Tgalpha-CaMkII-tTA; line B; pCaMKII-tTA |
| Gene Symbol and Name | Tg(Camk2a-tTA)1Mmay, transgene insertion 1, Mark Mayford |
| Gene Synonym(s) | CAMK-rTA; CaMKIIalpha-tTA; CamDAT; Tg(alphacre); Tg(CaMKIItTA)Mmay; Tgalpha-CaMkII-tTA; pCaMKII-tTA |
| Promoter | Camk2a, calcium/calmodulin-dependent protein kinase II alpha, mouse, laboratory |
| Expressed Gene | tTA, tetracycline-controlled transactivator, E. coli |
| Site of Expression | Expresses tTA in forebrain neurons. |
| Strain of Origin | Not Specified |
| Chromosome | UN |
| General Note | This transgene is line B. Transgenic mice are viable, fertile, and display no overt phenotypic defects. Administration of tetracycline analogs such as doxycycline blocks transgene expression. |
| Molecular Note | The transgene contains the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain specific calcium/calmodulin-dependent kinase II promoter. |
| Mutations Made By | Dr. Mark Mayford, The Scripps Research Institute |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Neurobiology Research
- Tet Expression System
- tTA/rtTA Expressing Strains
- Tet Expression System
- Research Tools
- Neurobiology Research
- Tetop Tet System
- Tet Expression Systems
- tTA/rtTA Expressing Strains
- Neurobiology Research
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tg(Camk2a-tTA)1Mmay/0
involves: C3H/HeJ * C57BL/6 * CBA
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - cell loss is not observed in 2 week old mice (MGI Ref ID J:185792)
- Background Sensitivity - granule cell layer of the dentate gyrus is reduced and disorganized in 2 month old mice as compared to non-transgenic controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- Background Sensitivity - width of granule cell layer is 42% thinner than controls by 2-4 months (MGI Ref ID J:185792)
- Background Sensitivity - width of granule cell layer is 68% thinner than controls by 6-9 months (MGI Ref ID J:185792)
- however, when mice are reared on doxycycline, cell loss is not observed (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- neuronal degeneration is progressive (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x FVB/NJ)F1
nervous system phenotype
- abnormal dentate gyrus morphology
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x C3H/HeJ)F1
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - width of granule cell layer is 14% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- Background Sensitivity - width of granule cell layer is 14% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x DBA/1J)F1
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - width of granule cell layer is 17% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- Background Sensitivity - width of granule cell layer is 17% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x C3H/HeJ)F1 x C3H/HeJ
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - width of granule cell layer is 29% thinner than controls and C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- Background Sensitivity - width of granule cell layer is 29% thinner than controls and C57BL/6 congenic background (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x CBA/J)F1
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - width of granule cell layer is 30% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- Background Sensitivity - width of granule cell layer is 30% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/0
129S6.Cg-Tg(Camk2a-tTA)1Mmay
nervous system phenotype
- abnormal forebrain morphology
- reduced forebrain weight in 2-6, 13-17, and 24-27 month old mice (MGI Ref ID J:235351)
- decreased dentate gyrus size
- (MGI Ref ID J:235351)
- thin cerebellar granule layer
- (MGI Ref ID J:235351)
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x 129X1/SvJ)F1
behavior/neurological phenotype
- impaired contextual conditioning behavior
- Background Sensitivity - freezing in response to unsignaled foot shock decreases in mutant and increases in control during final minutes of 5 minute test (MGI Ref ID J:185792)
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - width of granule cell layer is 27% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- Background Sensitivity - width of granule cell layer is 27% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/?
B6.Cg-Tg(Camk2a-tTA)1Mmay
behavior/neurological phenotype
- abnormal long term spatial reference memory
- mice swim less distance in the target quadrant than controls when tested for long-term recall suggesting a memory consolidation impairment (MGI Ref ID J:185792)
nervous system phenotype
References
- Mayford M; Bach ME; Huang YY; Wang L; Hawkins RD; Kandel ER. 1996. Control of memory formation through regulated expression of a CaMKII transgene.. In: . . MGI: J:37107
Additional References
- Lindeberg J; Mattsson R; Ebendal T. 2002. Timing the doxycycline yields different patterns of genomic recombination in brain neurons with a new inducible Cre transgene.. In: . . MGI: J:82535
- Rotenberg A; Mayford M; Hawkins RD; Kandel ER; Muller RU. 1996. Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus [see comments]. In: . . MGI: J:37455
Additional - Tg(Camk2a-tTA)1Mmay related
- Ageta H; Ikegami S; Miura M; Masuda M; Migishima R; Hino T; Takashima N; Murayama A; Sugino H; Setou M; Kida S; Yokoyama M; Hasegawa Y; Tsuchida K; Aosaki T; Inokuchi K. 2010. Activin plays a key role in the maintenance of long-term memory and late-LTP.. In: . . MGI: J:185839
- Ainsley JA; Drane L; Jacobs J; Kittelberger KA; Reijmers LG. 2014. Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience.. In: . . MGI: J:212973
- Aleksic T; Baumann B; Wagner M; Adler G; Wirth T; Weber CK. 2007. Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2.. In: . . MGI: J:130547
- Alexander GM; Rogan SC; Abbas AI; Armbruster BN; Pei Y; Allen JA; Nonneman RJ; Hartmann J; Moy SS; Nicolelis MA; McNamara JO; Roth BL. 2009. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors.. In: . . MGI: J:154952
- Alfieri JA; Pino NS; Igaz LM. 2014. Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies.. In: . . MGI: J:217404
- Alvarez-Saavedra M; Saez MA; Kang D; Zoghbi HY; Young JI. 2007. Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis.. In: . . MGI: J:124365
- Badanich KA; Doremus-Fitzwater TL; Mulholland PJ; Randall PK; Delpire E; Becker HC. 2011. NR2B-deficient mice are more sensitive to the locomotor stimulant and depressant effects of ethanol.. In: . . MGI: J:188172
- Bailey RM; Howard J; Knight J; Sahara N; Dickson DW; Lewis J. 2014. Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model.. In: . . MGI: J:230408
- Barco A; Patterson S; Alarcon JM; Gromova P; Mata-Roig M; Morozov A; Kandel ER. 2005. Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture.. In: . . MGI: J:105355
- Bedford L; Hay D; Devoy A; Paine S; Powe DG; Seth R; Gray T; Topham I; Fone K; Rezvani N; Mee M; Soane T; Layfield R; Sheppard PW; Ebendal T; Usoskin D; Lowe J; Mayer RJ. 2008. Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.. In: . . MGI: J:138991
- Bejar R; Yasuda R; Krugers H; Hood K; Mayford M. 2002. Transgenic calmodulin-dependent protein kinase II activation: dose-dependent effects on synaptic plasticity, learning, and memory.. In: . . MGI: J:112443
- Bennett RE; DeVos SL; Dujardin S; Corjuc B; Gor R; Gonzalez J; Roe AD; Frosch MP; Pitstick R; Carlson GA; Hyman BT. 2017. Enhanced Tau Aggregation in the Presence of Amyloid beta.. In: . . MGI: J:243583
- Bertocchi I; Oberto A; Longo A; Mele P; Sabetta M; Bartolomucci A; Palanza P; Sprengel R; Eva C. 2011. Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care.. In: . . MGI: J:180396
- Bethge P; Carta S; Lorenzo DA; Egolf L; Goniotaki D; Madisen L; Voigt FF; Chen JL; Schneider B; Ohkura M; Nakai J; Zeng H; Aguzzi A; Helmchen F. 2017. An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator.. In: . . MGI: J:241918
- Born HA; Kim JY; Savjani RR; Das P; Dabaghian YA; Guo Q; Yoo JW; Schuler DR; Cirrito JR; Zheng H; Golde TE; Noebels JL; Jankowsky JL. 2014. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.. In: . . MGI: J:209607
- Bosch C; Masachs N; Exposito-Alonso D; Martinez A; Teixeira CM; Fernaud I; Pujadas L; Ulloa F; Comella JX; DeFelipe J; Merchan-Perez A; Soriano E. 2016. Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells.. In: . . MGI: J:236241
- Cao L; Molina J; Abad C; Carmona-Mora P; Cardenas Oyarzo A; Young JI; Walz K. 2014. Correct developmental expression level of Rai1 in forebrain neurons is required for control of body weight, activity levels and learning and memory.. In: . . MGI: J:207141
- Carvalho Poyraz F; Holzner E; Bailey MR; Meszaros J; Kenney L; Kheirbek MA; Balsam PD; Kellendonk C. 2016. Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action.. In: . . MGI: J:234093
- Castello NA; Nguyen MH; Tran JD; Cheng D; Green KN; LaFerla FM. 2014. 7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss.. In: . . MGI: J:215124
- Chandrasekaran K; Hazelton JL; Wang Y; Fiskum G; Kristian T. 2006. Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in mice.. In: . . MGI: J:118452
- Chang KH; Multani PS; Sun KH; Vincent F; de Pablo Y; Ghosh S; Gupta R; Lee HP; Lee HG; Smith MA; Shah K. 2011. Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death.. In: . . MGI: J:182975
- Cheetham CE; Park U; Belluscio L. 2016. Rapid and continuous activity-dependent plasticity of olfactory sensory input.. In: . . MGI: J:234735
- Chen AP; Ohno M; Giese KP; Kuhn R; Chen RL; Silva AJ. 2006. Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory.. In: . . MGI: J:107042
- Chen L; Ding Y; Cagniard B; Van Laar AD; Mortimer A; Chi W; Hastings TG; Kang UJ; Zhuang X. 2008. Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice.. In: . . MGI: J:131093
- Cheng HY; Dziema H; Papp J; Mathur DP; Koletar M; Ralph MR; Penninger JM; Obrietan K. 2006. The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock.. In: . . MGI: J:116668
- Cheng J; Ji D. 2013. Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model.. In: . . MGI: J:207802
- Cheng N; Cai H; Belluscio L. 2011. In Vivo Olfactory Model of APP-Induced Neurodegeneration Reveals a Reversible Cell-Autonomous Function.. In: . . MGI: J:176127
- Cheng N; Jiao S; Gumaste A; Bai L; Belluscio L. 2016. APP Overexpression Causes Abeta-Independent Neuronal Death through Intrinsic Apoptosis Pathway.. In: . . MGI: J:237784
- Chiu C; Reid CA; Tan HO; Davies PJ; Single FN; Koukoulas I; Berkovic SF; Tan SS; Sprengel R; Jones MV; Petrou S. 2008. Developmental impact of a familial GABAA receptor epilepsy mutation.. In: . . MGI: J:194736
- Cho C; MacDonald R; Shang J; Cho MJ; Chalifour LE; Paudel HK. 2017. Early growth response-1-mediated down-regulation of drebrin correlates with loss of dendritic spines.. In: . . MGI: J:243216
- Chuhma N; Tanaka KF; Hen R; Rayport S. 2011. Functional connectome of the striatal medium spiny neuron.. In: . . MGI: J:188102
- Ciupek SM; Cheng J; Ali YO; Lu HC; Ji D. 2015. Progressive functional impairments of hippocampal neurons in a tauopathy mouse model.. In: . . MGI: J:222240
- Cook C; Dunmore JH; Murray ME; Scheffel K; Shukoor N; Tong J; Castanedes-Casey M; Phillips V; Rousseau L; Penuliar MS; Kurti A; Dickson DW; Petrucelli L; Fryer JD. 2014. Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia.. In: . . MGI: J:207366
- Crook ZR; Housman D. 2011. Huntington's disease: can mice lead the way to treatment?. In: . . MGI: J:174750
- Cruz JC; Tseng HC; Goldman JA; Shih H; Tsai LH. 2003. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles.. In: . . MGI: J:104240
- Diaz-Hernandez M; Diez-Zaera M; Sanchez-Nogueiro J; Gomez-Villafuertes R; Canals JM; Alberch J; Miras-Portugal MT; Lucas JJ. 2009. Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration.. In: . . MGI: J:150552
- Drane L; Ainsley JA; Mayford MR; Reijmers LG. 2014. A transgenic mouse line for collecting ribosome-bound mRNA using the tetracycline transactivator system.. In: . . MGI: J:215826
- DuBoff B; Gotz J; Feany MB. 2012. Tau promotes neurodegeneration via DRP1 mislocalization in vivo.. In: . . MGI: J:188334
- Eckermann K; Mocanu MM; Khlistunova I; Biernat J; Nissen A; Hofmann A; Schonig K; Bujard H; Haemisch A; Mandelkow E; Zhou L; Rune G; Mandelkow EM. 2007. The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy.. In: . . MGI: J:126788
- Elkharaz J; Ugun-Klusek A; Constantin-Teodosiu D; Lawler K; Mayer RJ; Billett E; Lowe J; Bedford L. 2013. Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones.. In: . . MGI: J:204108
- Engel T; Goni-Oliver P; Gomez-Ramos P; Moran MA; Lucas JJ; Avila J; Hernandez F. 2008. Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta.. In: . . MGI: J:144874
- Engel T; Lucas JJ; Gomez-Ramos P; Moran MA; Avila J; Hernandez F. 2006. Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration.. In: . . MGI: J:113439
- Favilla C; Abel T; Kelly MP. 2008. Chronic Galphas signaling in the striatum increases anxiety-related behaviors independent of developmental effects.. In: . . MGI: J:143516
- Fleischmann A; Abdus-Saboor I; Sayed A; Shykind B. 2013. Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation.. In: . . MGI: J:201434
- Formentini L; Pereira MP; Sanchez-Cenizo L; Santacatterina F; Lucas JJ; Navarro C; Martinez-Serrano A; Cuezva JM. 2014. In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning.. In: . . MGI: J:208039
- Fretham SJ; Carlson ES; Wobken J; Tran PV; Petryk A; Georgieff MK. 2012. Temporal manipulation of transferrin-receptor-1-dependent iron uptake identifies a sensitive period in mouse hippocampal neurodevelopment.. In: . . MGI: J:241563
- Freudenberg F; Marx V; Mack V; Layer LE; Klugmann M; Seeburg PH; Sprengel R; Celikel T. 2013. GluA1 and its PDZ-interaction: a role in experience-dependent behavioral plasticity in the forced swim test.. In: . . MGI: J:197650
- Fridmacher V; Kaltschmidt B; Goudeau B; Ndiaye D; Rossi FM; Pfeiffer J; Kaltschmidt C; Israel A; Memet S. 2003. Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection.. In: . . MGI: J:86217
- Fromholt S; Reitano C; Brown H; Lewis J; Borchelt DR. 2016. Generation of a new transgenic mouse model for assessment of tau gene silencing therapies.. In: . . MGI: J:234694
- Fukui H; Moraes CT. 2009. Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons.. In: . . MGI: J:145737
- Fuster-Matanzo A; Llorens-Martin M; Sirerol-Piquer MS; Garcia-Verdugo JM; Avila J; Hernandez F. 2013. Dual effects of increased glycogen synthase kinase-3beta activity on adult neurogenesis.. In: . . MGI: J:193849
- Giusti-Rodriguez P; Gao J; Graff J; Rei D; Soda T; Tsai LH. 2011. Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of beta-Secretase (BACE1).. In: . . MGI: J:177847
- Gjoneska E; Pfenning AR; Mathys H; Quon G; Kundaje A; Tsai LH; Kellis M. 2015. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease.. In: . . MGI: J:219866
- Gomez de Barreda E; Perez M; Gomez Ramos P; de Cristobal J; Martin-Maestro P; Moran A; Dawson HN; Vitek MP; Lucas JJ; Hernandez F; Avila J. 2010. Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits.. In: . . MGI: J:158536
- Gomez-Sintes R; Hernandez F; Bortolozzi A; Artigas F; Avila J; Zaratin P; Gotteland JP; Lucas JJ. 2007. Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.. In: . . MGI: J:122627
- Gross C; Zhuang X; Stark K; Ramboz S; Oosting R; Kirby L; Santarelli L; Beck S; Hen R. 2002. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult.. In: . . MGI: J:75722
- Gruart A; Benito E; Delgado-Garcia JM; Barco A. 2012. Enhanced cAMP response element-binding protein activity increases neuronal excitability, hippocampal long-term potentiation, and classical eyeblink conditioning in alert behaving mice.. In: . . MGI: J:193114
- Han HJ; Allen CC; Buchovecky CM; Yetman MJ; Born HA; Marin MA; Rodgers SP; Song BJ; Lu HC; Justice MJ; Probst FJ; Jankowsky JL. 2012. Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator.. In: . . MGI: J:185792
- Hansen KF; Sakamoto K; Wayman GA; Impey S; Obrietan K. 2010. Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory.. In: . . MGI: J:167123
- Hasan MT; Schonig K; Berger S; Graewe W; Bujard H. 2001. Long-term, noninvasive imaging of regulated gene expression in living mice.. In: . . MGI: J:127660
- Hawk JD; Bookout AL; Poplawski SG; Bridi M; Rao AJ; Sulewski ME; Kroener BT; Manglesdorf DJ; Abel T. 2012. NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors.. In: . . MGI: J:191754
- Heng MY; Lin ST; Verret L; Huang Y; Kamiya S; Padiath QS; Tong Y; Palop JJ; Huang EJ; Ptacek LJ; Fu YH. 2013. Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model.. In: . . MGI: J:197168
- Hidvegi T; Schmidt BZ; Hale P; Perlmutter DH. 2005. Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.. In: . . MGI: J:104112
- Holehonnur R; Phensy AJ; Kim LJ; Milivojevic M; Vuong D; Daison DK; Alex S; Tiner M; Jones LE; Kroener S; Ploski JE. 2016. Increasing the GluN2A/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace.. In: . . MGI: J:235283
- Hunsberger HC; Rudy CC; Batten SR; Gerhardt GA; Reed MN. 2015. P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway.. In: . . MGI: J:218026
- Igaz LM; Kwong LK; Lee EB; Chen-Plotkin A; Swanson E; Unger T; Malunda J; Xu Y; Winton MJ; Trojanowski JQ; Lee VM. 2011. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.. In: . . MGI: J:170756
- Isiegas C; McDonough C; Huang T; Havekes R; Fabian S; Wu LJ; Xu H; Zhao MG; Kim JI; Lee YS; Lee HR; Ko HG; Lee N; Choi SL; Lee JS; Son H; Zhuo M; Kaang BK; Abel T. 2008. A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval.. In: . . MGI: J:137375
- Jancic D; Lopez de Armentia M; Valor LM; Olivares R; Barco A. 2009. Inhibition of cAMP response element-binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration.. In: . . MGI: J:211460
- Jankowsky JL; Slunt HH; Gonzales V; Savonenko AV; Wen JC; Jenkins NA; Copeland NG; Younkin LH; Lester HA; Younkin SG; Borchelt DR. 2005. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.. In: . . MGI: J:109829
- Jerecic J; Schulze CH; Jonas P; Sprengel R; Seeburg PH; Bischofberger J. 2001. Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression.. In: . . MGI: J:130561
- Joly-Amado A; Serraneau KS; Brownlow M; Marin de Evsikova C; Speakman JR; Gordon MN; Morgan D. 2016. Metabolic changes over the course of aging in a mouse model of tau deposition.. In: . . MGI: J:239040
- Kabitzke PA; Simpson EH; Kandel ER; Balsam PD. 2015. Social behavior in a genetic model of dopamine dysfunction at different neurodevelopmental time points.. In: . . MGI: J:235997
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