JAX
Mouse Strain Datasheet - 003010
B6;CBA-Tg(Camk2a-tTA)1Mmay/J
Also Known As: CaMKII-tTA
This strain will be removed from the shelf. Estimated removal of Live Colony date: 29 June 2017. Replacement congenic strain is Stock No. 007004.
When these Camk2a-tTA transgenic mice are mated to strain carrying a gene of interest under the regulatory control of a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene can be blocked by administration of the tetracycline analog, doxycycline. These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's, Parkinson's disease, or other neurodegenerative diseases.
Donating Investigator
Dr. Mark Mayford, The Scripps Research Institute
Genetic overview
| Genetic Background | Generation |
|---|---|
|
F?+N3F2
|
Tg(Camk2a-tTA)1Mmay
| Allele Type |
|---|
| Transgenic (Transactivator) |
Base Price
Starting at:
| $333.00 Domestic price for female |
| $407.00 Domestic price for breeder pair |
Detailed Description
Transgenic mice expressing the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain-specific calcium-calmodulin-dependent kinase II (Camk2a) promoter are viable and fertile. When hemizygotes are mated to a second strain carrying a gene of interest under the regulatory control of a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene can be blocked by administration of the tetracycline analog, doxycycline (dox). These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's disease (when used in conjunction with Stock No. 005706, Stock No. 007049, Stock No. 007051, Stock No. 007052), Parkinson's disease (Stock No. 013583), or other neurodegenerative diseases.
Of note, mice expressing Tg(Camk2a-tTA)1Mmay on the C57BL/6 background exhibit resistance to tTA-induced neurotoxicity (dentate gyrus granule cell layer atrophy). All other backgrounds tested (FVB/NJ, CBA/J, 129X1/SvJ, C3H/HeJ, DBA/1J) exhibit varying levels of neurotoxicity (Han et. al. 2012 J Neurosci 32:10574).
Development
A transgenic construct was designed with 8.5 kb of the mouse CaMKIIalpha promoter placed upstream of the tetracycline-regulated transactivator (tTA or Tet-Off) gene (flanked by an artificial intron and splice sites at the 5' end and by a polyadenylation signal from SV40 at the 3' end). Founder line B was established and maintained on a mixed B6;CBA genetic background upon its arrival at The Jackson Laboratory.
Expression Data
| Expressed Gene | tTA, tetracycline-controlled transactivator, E. coli |
|---|---|
| Site of Expression | Expresses tTA in forebrain neurons. |
Control Suggestions
Selected References
- Mayford M; Bach ME; Huang YY; Wang L; Hawkins RD; Kandel ER. 1996. Control of memory formation through regulated expression of a CaMKII transgene. Science 274(5293):1678-83. PubMed: 8939850MGI: J:37107
Tg(Camk2a-tTA)1Mmay
Allele Symbol: Tg(Camk2a-tTA)1Mmay
| Allele Name | transgene insertion 1, Mark Mayford |
|---|---|
| Allele Type | Transgenic (Transactivator) |
| Allele Synonym(s) | CAMK-rTA; CaMKII-tTA; CaMKIIalpha-tTA; CamDAT; Tg(CaMKIItTA)Mmay; Tgalpha-CaMkII-tTA; line B; pCaMKII-tTA |
| Gene Symbol and Name | Tg(Camk2a-tTA)1Mmay, transgene insertion 1, Mark Mayford |
| Gene Synonym(s) | CAMK-rTA; CaMKIIalpha-tTA; CamDAT; Tg(alphacre); Tg(CaMKIItTA)Mmay; Tgalpha-CaMkII-tTA; pCaMKII-tTA |
| Promoter | Camk2a, calcium/calmodulin-dependent protein kinase II alpha, mouse, laboratory |
| Expressed Gene | tTA, tetracycline-controlled transactivator, E. coli |
| Site of Expression | Expresses tTA in forebrain neurons. |
| Strain of Origin | Not Specified |
| Chromosome | UN |
| General Note | This transgene is line B. Transgenic mice are viable, fertile, and display no overt phenotypic defects. Administration of tetracycline analogs such as doxycycline blocks transgene expression. |
| Molecular Note | The transgene contains the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain specific calcium/calmodulin-dependent kinase II promoter. |
| Mutations Made By | Dr. Mark Mayford, The Scripps Research Institute |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Neurobiology Research
- Tet Expression System
- tTA/rtTA Expressing Strains
- Tet Expression System
- Research Tools
- Neurobiology Research
- Tetop Tet System
- Tet Expression Systems
- tTA/rtTA Expressing Strains
- Neurobiology Research
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tg(Camk2a-tTA)1Mmay/0
involves: C3H/HeJ * C57BL/6 * CBA
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - cell loss is not observed in 2 week old mice (MGI Ref ID J:185792)
- Background Sensitivity - granule cell layer of the dentate gyrus is reduced and disorganized in 2 month old mice as compared to non-transgenic controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- Background Sensitivity - width of granule cell layer is 42% thinner than controls by 2-4 months (MGI Ref ID J:185792)
- Background Sensitivity - width of granule cell layer is 68% thinner than controls by 6-9 months (MGI Ref ID J:185792)
- however, when mice are reared on doxycycline, cell loss is not observed (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- neuronal degeneration is progressive (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x FVB/NJ)F1
nervous system phenotype
- abnormal dentate gyrus morphology
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x C3H/HeJ)F1
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - width of granule cell layer is 14% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- Background Sensitivity - width of granule cell layer is 14% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x DBA/1J)F1
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - width of granule cell layer is 17% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- Background Sensitivity - width of granule cell layer is 17% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x C3H/HeJ)F1 x C3H/HeJ
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - width of granule cell layer is 29% thinner than controls and C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- Background Sensitivity - width of granule cell layer is 29% thinner than controls and C57BL/6 congenic background (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x CBA/J)F1
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - width of granule cell layer is 30% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- Background Sensitivity - width of granule cell layer is 30% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/0
129S6.Cg-Tg(Camk2a-tTA)1Mmay
nervous system phenotype
- abnormal forebrain morphology
- reduced forebrain weight in 2-6, 13-17, and 24-27 month old mice (MGI Ref ID J:235351)
- decreased dentate gyrus size
- (MGI Ref ID J:235351)
- thin cerebellar granule layer
- (MGI Ref ID J:235351)
Genotype: Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x 129X1/SvJ)F1
behavior/neurological phenotype
- impaired contextual conditioning behavior
- Background Sensitivity - freezing in response to unsignaled foot shock decreases in mutant and increases in control during final minutes of 5 minute test (MGI Ref ID J:185792)
nervous system phenotype
- abnormal dentate gyrus morphology
- Background Sensitivity - width of granule cell layer is 27% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- Background Sensitivity - width of granule cell layer is 27% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Genotype: Tg(Camk2a-tTA)1Mmay/?
B6.Cg-Tg(Camk2a-tTA)1Mmay
behavior/neurological phenotype
- abnormal long term spatial reference memory
- mice swim less distance in the target quadrant than controls when tested for long-term recall suggesting a memory consolidation impairment (MGI Ref ID J:185792)
nervous system phenotype
References
- Mayford M; Bach ME; Huang YY; Wang L; Hawkins RD; Kandel ER. 1996. Control of memory formation through regulated expression of a CaMKII transgene. Science 274(5293):1678-83. PubMed: 8939850MGI: J:37107
Additional References
- Lindeberg J; Mattsson R; Ebendal T. 2002. Timing the doxycycline yields different patterns of genomic recombination in brain neurons with a new inducible Cre transgene. J Neurosci Res 68(2):248-53. PubMed: 11948670MGI: J:82535
- Rotenberg A; Mayford M; Hawkins RD; Kandel ER; Muller RU. 1996. Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus [see comments] Cell 87(7):1351-61. PubMed: 8980240MGI: J:37455
Additional - Tg(Camk2a-tTA)1Mmay related
- Ageta H; Ikegami S; Miura M; Masuda M; Migishima R; Hino T; Takashima N; Murayama A; Sugino H; Setou M; Kida S; Yokoyama M; Hasegawa Y; Tsuchida K; Aosaki T; Inokuchi K. 2010. Activin plays a key role in the maintenance of long-term memory and late-LTP. Learn Mem 17(4):176-85. PubMed: 20332189MGI: J:185839
- Ainsley JA; Drane L; Jacobs J; Kittelberger KA; Reijmers LG. 2014. Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience. Nat Commun 5:4510. PubMed: 25072471MGI: J:212973
- Aleksic T; Baumann B; Wagner M; Adler G; Wirth T; Weber CK. 2007. Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2. Gut 56(2):227-36. PubMed: 16870717MGI: J:130547
- Alexander GM; Rogan SC; Abbas AI; Armbruster BN; Pei Y; Allen JA; Nonneman RJ; Hartmann J; Moy SS; Nicolelis MA; McNamara JO; Roth BL. 2009. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63(1):27-39. PubMed: 19607790MGI: J:154952
- Alfieri JA; Pino NS; Igaz LM. 2014. Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies. J Neurosci 34(46):15244-59. PubMed: 25392493MGI: J:217404
- Alvarez-Saavedra M; Saez MA; Kang D; Zoghbi HY; Young JI. 2007. Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis. Hum Mol Genet 16(19):2315-25. PubMed: 17635839MGI: J:124365
- Badanich KA; Doremus-Fitzwater TL; Mulholland PJ; Randall PK; Delpire E; Becker HC. 2011. NR2B-deficient mice are more sensitive to the locomotor stimulant and depressant effects of ethanol. Genes Brain Behav 10(7):805-16. PubMed: 21762461MGI: J:188172
- Bailey RM; Howard J; Knight J; Sahara N; Dickson DW; Lewis J. 2014. Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model. Mol Neurodegener 9:8. PubMed: 24428919MGI: J:230408
- Barco A; Patterson S; Alarcon JM; Gromova P; Mata-Roig M; Morozov A; Kandel ER. 2005. Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture. Neuron 48(1):123-37. PubMed: 16202713MGI: J:105355
- Bedford L; Hay D; Devoy A; Paine S; Powe DG; Seth R; Gray T; Topham I; Fone K; Rezvani N; Mee M; Soane T; Layfield R; Sheppard PW; Ebendal T; Usoskin D; Lowe J; Mayer RJ. 2008. Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies. J Neurosci 28(33):8189-98. PubMed: 18701681MGI: J:138991
- Bejar R; Yasuda R; Krugers H; Hood K; Mayford M. 2002. Transgenic calmodulin-dependent protein kinase II activation: dose-dependent effects on synaptic plasticity, learning, and memory. J Neurosci 22(13):5719-26. PubMed: 12097524MGI: J:112443
- Bertocchi I; Oberto A; Longo A; Mele P; Sabetta M; Bartolomucci A; Palanza P; Sprengel R; Eva C. 2011. Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care. Proc Natl Acad Sci U S A 108(48):19395-400. PubMed: 22084082MGI: J:180396
- Bethge P; Carta S; Lorenzo DA; Egolf L; Goniotaki D; Madisen L; Voigt FF; Chen JL; Schneider B; Ohkura M; Nakai J; Zeng H; Aguzzi A; Helmchen F. 2017. An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator. PLoS One 12(6):e0179460. PubMed: 28640817MGI: J:241918
- Born HA; Kim JY; Savjani RR; Das P; Dabaghian YA; Guo Q; Yoo JW; Schuler DR; Cirrito JR; Zheng H; Golde TE; Noebels JL; Jankowsky JL. 2014. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. J Neurosci 34(11):3826-40. PubMed: 24623762MGI: J:209607
- Bosch C; Masachs N; Exposito-Alonso D; Martinez A; Teixeira CM; Fernaud I; Pujadas L; Ulloa F; Comella JX; DeFelipe J; Merchan-Perez A; Soriano E. 2016. Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells. Cereb Cortex :. PubMed: 27624722MGI: J:236241
- Cao L; Molina J; Abad C; Carmona-Mora P; Cardenas Oyarzo A; Young JI; Walz K. 2014. Correct developmental expression level of Rai1 in forebrain neurons is required for control of body weight, activity levels and learning and memory. Hum Mol Genet 23(7):1771-82. PubMed: 24218365MGI: J:207141
- Carvalho Poyraz F; Holzner E; Bailey MR; Meszaros J; Kenney L; Kheirbek MA; Balsam PD; Kellendonk C. 2016. Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action. J Neurosci 36(22):5988-6001. PubMed: 27251620MGI: J:234093
- Castello NA; Nguyen MH; Tran JD; Cheng D; Green KN; LaFerla FM. 2014. 7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss. PLoS One 9(3):e91453. PubMed: 24614170MGI: J:215124
- Chandrasekaran K; Hazelton JL; Wang Y; Fiskum G; Kristian T. 2006. Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in mice. J Neurosci 26(51):13123-7. PubMed: 17182763MGI: J:118452
- Chang KH; Multani PS; Sun KH; Vincent F; de Pablo Y; Ghosh S; Gupta R; Lee HP; Lee HG; Smith MA; Shah K. 2011. Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death. Mol Biol Cell 22(9):1452-62. PubMed: 21389115MGI: J:182975
- Cheetham CE; Park U; Belluscio L. 2016. Rapid and continuous activity-dependent plasticity of olfactory sensory input. Nat Commun 7:10729. PubMed: 26898529MGI: J:234735
- Chen AP; Ohno M; Giese KP; Kuhn R; Chen RL; Silva AJ. 2006. Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory. J Neurosci Res 83(1):28-38. PubMed: 16342120MGI: J:107042
- Chen L; Ding Y; Cagniard B; Van Laar AD; Mortimer A; Chi W; Hastings TG; Kang UJ; Zhuang X. 2008. Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice. J Neurosci 28(2):425-33. PubMed: 18184785MGI: J:131093
- Cheng HY; Dziema H; Papp J; Mathur DP; Koletar M; Ralph MR; Penninger JM; Obrietan K. 2006. The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. J Neurosci 26(50):12984-95. PubMed: 17167088MGI: J:116668
- Cheng J; Ji D. 2013. Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model. Elife 2:e00647. PubMed: 23805379MGI: J:207802
- Cheng N; Cai H; Belluscio L. 2011. In Vivo Olfactory Model of APP-Induced Neurodegeneration Reveals a Reversible Cell-Autonomous Function. J Neurosci 31(39):13699-704. PubMed: 21957232MGI: J:176127
- Cheng N; Jiao S; Gumaste A; Bai L; Belluscio L. 2016. APP Overexpression Causes Abeta-Independent Neuronal Death through Intrinsic Apoptosis Pathway. eNeuro 3(4):. PubMed: 27517085MGI: J:237784
- Chiu C; Reid CA; Tan HO; Davies PJ; Single FN; Koukoulas I; Berkovic SF; Tan SS; Sprengel R; Jones MV; Petrou S. 2008. Developmental impact of a familial GABAA receptor epilepsy mutation. Ann Neurol 64(3):284-93. PubMed: 18825662MGI: J:194736
- Chuhma N; Tanaka KF; Hen R; Rayport S. 2011. Functional connectome of the striatal medium spiny neuron. J Neurosci 31(4):1183-92. PubMed: 21273403MGI: J:188102
- Ciupek SM; Cheng J; Ali YO; Lu HC; Ji D. 2015. Progressive functional impairments of hippocampal neurons in a tauopathy mouse model. J Neurosci 35(21):8118-31. PubMed: 26019329MGI: J:222240
- Cook C; Dunmore JH; Murray ME; Scheffel K; Shukoor N; Tong J; Castanedes-Casey M; Phillips V; Rousseau L; Penuliar MS; Kurti A; Dickson DW; Petrucelli L; Fryer JD. 2014. Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia. Neurobiol Aging 35(7):1769-77. PubMed: 24503275MGI: J:207366
- Crook ZR; Housman D. 2011. Huntington's disease: can mice lead the way to treatment? Neuron 69(3):423-35. PubMed: 21315254MGI: J:174750
- Cruz JC; Tseng HC; Goldman JA; Shih H; Tsai LH. 2003. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40(3):471-83. PubMed: 14642273MGI: J:104240
- Diaz-Hernandez M; Diez-Zaera M; Sanchez-Nogueiro J; Gomez-Villafuertes R; Canals JM; Alberch J; Miras-Portugal MT; Lucas JJ. 2009. Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration. FASEB J 23(6):1893-906. PubMed: 19171786MGI: J:150552
- Drane L; Ainsley JA; Mayford MR; Reijmers LG. 2014. A transgenic mouse line for collecting ribosome-bound mRNA using the tetracycline transactivator system. Front Mol Neurosci 7:82. PubMed: 25400545MGI: J:215826
- DuBoff B; Gotz J; Feany MB. 2012. Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron 75(4):618-32. PubMed: 22920254MGI: J:188334
- Eckermann K; Mocanu MM; Khlistunova I; Biernat J; Nissen A; Hofmann A; Schonig K; Bujard H; Haemisch A; Mandelkow E; Zhou L; Rune G; Mandelkow EM. 2007. The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem 282(43):31755-65. PubMed: 17716969MGI: J:126788
- Elkharaz J; Ugun-Klusek A; Constantin-Teodosiu D; Lawler K; Mayer RJ; Billett E; Lowe J; Bedford L. 2013. Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones. Biochim Biophys Acta 1832(12):1930-8. PubMed: 23851049MGI: J:204108
- Engel T; Goni-Oliver P; Gomez-Ramos P; Moran MA; Lucas JJ; Avila J; Hernandez F. 2008. Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta. Neuroscience 157(4):772-80. PubMed: 18951953MGI: J:144874
- Engel T; Lucas JJ; Gomez-Ramos P; Moran MA; Avila J; Hernandez F. 2006. Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration. Neurobiol Aging 27(9):1258-68. PubMed: 16054268MGI: J:113439
- Favilla C; Abel T; Kelly MP. 2008. Chronic Galphas signaling in the striatum increases anxiety-related behaviors independent of developmental effects. J Neurosci 28(51):13952-6. PubMed: 19091983MGI: J:143516
- Fleischmann A; Abdus-Saboor I; Sayed A; Shykind B. 2013. Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation. PLoS Biol 11(5):e1001568. PubMed: 23700388MGI: J:201434
- Formentini L; Pereira MP; Sanchez-Cenizo L; Santacatterina F; Lucas JJ; Navarro C; Martinez-Serrano A; Cuezva JM. 2014. In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning. EMBO J 33(7):762-78. PubMed: 24521670MGI: J:208039
- Fretham SJ; Carlson ES; Wobken J; Tran PV; Petryk A; Georgieff MK. 2012. Temporal manipulation of transferrin-receptor-1-dependent iron uptake identifies a sensitive period in mouse hippocampal neurodevelopment. Hippocampus 22(8):1691-702. PubMed: 22367974MGI: J:241563
- Freudenberg F; Marx V; Mack V; Layer LE; Klugmann M; Seeburg PH; Sprengel R; Celikel T. 2013. GluA1 and its PDZ-interaction: a role in experience-dependent behavioral plasticity in the forced swim test. Neurobiol Dis 52:160-7. PubMed: 23262314MGI: J:197650
- Fridmacher V; Kaltschmidt B; Goudeau B; Ndiaye D; Rossi FM; Pfeiffer J; Kaltschmidt C; Israel A; Memet S. 2003. Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection. J Neurosci 23(28):9403-8. PubMed: 14561868MGI: J:86217
- Fromholt S; Reitano C; Brown H; Lewis J; Borchelt DR. 2016. Generation of a new transgenic mouse model for assessment of tau gene silencing therapies. Alzheimers Res Ther 8:36. PubMed: 27593210MGI: J:234694
- Fukui H; Moraes CT. 2009. Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons. Hum Mol Genet 18(6):1028-36. PubMed: 19095717MGI: J:145737
- Fuster-Matanzo A; Llorens-Martin M; Sirerol-Piquer MS; Garcia-Verdugo JM; Avila J; Hernandez F. 2013. Dual effects of increased glycogen synthase kinase-3beta activity on adult neurogenesis. Hum Mol Genet 22(7):1300-15. PubMed: 23257288MGI: J:193849
- Giusti-Rodriguez P; Gao J; Graff J; Rei D; Soda T; Tsai LH. 2011. Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of beta-Secretase (BACE1). J Neurosci 31(44):15751-6. PubMed: 22049418MGI: J:177847
- Gjoneska E; Pfenning AR; Mathys H; Quon G; Kundaje A; Tsai LH; Kellis M. 2015. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease. Nature 518(7539):365-9. PubMed: 25693568MGI: J:219866
- Gomez de Barreda E; Perez M; Gomez Ramos P; de Cristobal J; Martin-Maestro P; Moran A; Dawson HN; Vitek MP; Lucas JJ; Hernandez F; Avila J. 2010. Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis 37(3):622-9. PubMed: 20004245MGI: J:158536
- Gomez-Sintes R; Hernandez F; Bortolozzi A; Artigas F; Avila J; Zaratin P; Gotteland JP; Lucas JJ. 2007. Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice. EMBO J 26(11):2743-54. PubMed: 17510631MGI: J:122627
- Gross C; Zhuang X; Stark K; Ramboz S; Oosting R; Kirby L; Santarelli L; Beck S; Hen R. 2002. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416(6879):396-400. PubMed: 11919622MGI: J:75722
- Gruart A; Benito E; Delgado-Garcia JM; Barco A. 2012. Enhanced cAMP response element-binding protein activity increases neuronal excitability, hippocampal long-term potentiation, and classical eyeblink conditioning in alert behaving mice. J Neurosci 32(48):17431-41. PubMed: 23197734MGI: J:193114
- Han HJ; Allen CC; Buchovecky CM; Yetman MJ; Born HA; Marin MA; Rodgers SP; Song BJ; Lu HC; Justice MJ; Probst FJ; Jankowsky JL. 2012. Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator. J Neurosci 32(31):10574-86. PubMed: 22855807MGI: J:185792
- Hansen KF; Sakamoto K; Wayman GA; Impey S; Obrietan K. 2010. Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory. PLoS One 5(11):e15497. PubMed: 21124738MGI: J:167123
- Hasan MT; Schonig K; Berger S; Graewe W; Bujard H. 2001. Long-term, noninvasive imaging of regulated gene expression in living mice. Genesis 29(3):116-22. PubMed: 11252052MGI: J:127660
- Hawk JD; Bookout AL; Poplawski SG; Bridi M; Rao AJ; Sulewski ME; Kroener BT; Manglesdorf DJ; Abel T. 2012. NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors. J Clin Invest 122(10):3593-602. PubMed: 22996661MGI: J:191754
- Heng MY; Lin ST; Verret L; Huang Y; Kamiya S; Padiath QS; Tong Y; Palop JJ; Huang EJ; Ptacek LJ; Fu YH. 2013. Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model. J Clin Invest 123(6):2719-29. PubMed: 23676464MGI: J:197168
- Hidvegi T; Schmidt BZ; Hale P; Perlmutter DH. 2005. Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response. J Biol Chem 280(47):39002-15. PubMed: 16183649MGI: J:104112
- Holehonnur R; Phensy AJ; Kim LJ; Milivojevic M; Vuong D; Daison DK; Alex S; Tiner M; Jones LE; Kroener S; Ploski JE. 2016. Increasing the GluN2A/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace. J Neurosci 36(36):9490-504. PubMed: 27605622MGI: J:235283
- Hunsberger HC; Rudy CC; Batten SR; Gerhardt GA; Reed MN. 2015. P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway. J Neurochem 132(2):169-82. PubMed: 25319522MGI: J:218026
- Igaz LM; Kwong LK; Lee EB; Chen-Plotkin A; Swanson E; Unger T; Malunda J; Xu Y; Winton MJ; Trojanowski JQ; Lee VM. 2011. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest 121(2):726-38. PubMed: 21206091MGI: J:170756
- Isiegas C; McDonough C; Huang T; Havekes R; Fabian S; Wu LJ; Xu H; Zhao MG; Kim JI; Lee YS; Lee HR; Ko HG; Lee N; Choi SL; Lee JS; Son H; Zhuo M; Kaang BK; Abel T. 2008. A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. J Neurosci 28(24):6220-30. PubMed: 18550764MGI: J:137375
- Jancic D; Lopez de Armentia M; Valor LM; Olivares R; Barco A. 2009. Inhibition of cAMP response element-binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration. Cereb Cortex 19(11):2535-47. PubMed: 19213815MGI: J:211460
- Jankowsky JL; Slunt HH; Gonzales V; Savonenko AV; Wen JC; Jenkins NA; Copeland NG; Younkin LH; Lester HA; Younkin SG; Borchelt DR. 2005. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med 2(12):e355. PubMed: 16279840MGI: J:109829
- Jerecic J; Schulze CH; Jonas P; Sprengel R; Seeburg PH; Bischofberger J. 2001. Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression. Brain Res Mol Brain Res 94(1-2):96-104. PubMed: 11597769MGI: J:130561
- Joly-Amado A; Serraneau KS; Brownlow M; Marin de Evsikova C; Speakman JR; Gordon MN; Morgan D. 2016. Metabolic changes over the course of aging in a mouse model of tau deposition. Neurobiol Aging 44:62-73. PubMed: 27318134MGI: J:239040
- Kabitzke PA; Simpson EH; Kandel ER; Balsam PD. 2015. Social behavior in a genetic model of dopamine dysfunction at different neurodevelopmental time points. Genes Brain Behav 14(7):503-15. PubMed: 26176662MGI: J:235997
- Kaltschmidt B; Ndiaye D; Korte M; Pothion S; Arbibe L; Prullage M; Pfeiffer J; Lindecke A; Staiger V; Israel A; Kaltschmidt C; Memet S. 2006. NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling. Mol Cell Biol 26(8):2936-46. PubMed: 16581769MGI: J:107412
- Karlen A; Karlsson TE; Mattsson A; Lundstromer K; Codeluppi S; Pham TM; Backman CM; Ogren SO; Aberg E; Hoffman AF; Sherling MA; Lupica CR; Hoffer BJ; Spenger C; Josephson A; Brene S; Olson L. 2009. Nogo receptor 1 regulates formation of lasting memories. Proc Natl Acad Sci U S A 106(48):20476-81. PubMed: 19915139MGI: J:155587
- Karlsson TE; Smedfors G; Brodin AT; Aberg E; Mattsson A; Hogbeck I; Wellfelt K; Josephson A; Brene S; Olson L. 2016. NgR1: A Tunable Sensor Regulating Memory Formation, Synaptic, and Dendritic Plasticity. Cereb Cortex 26(4):1804-17. PubMed: 26838771MGI: J:231310
- Kassai H; Sugaya Y; Noda S; Nakao K; Maeda T; Kano M; Aiba A. 2014. Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep 7(5):1626-39. PubMed: 24857653MGI: J:211789
- Kellendonk C; Simpson EH; Polan HJ; Malleret G; Vronskaya S; Winiger V; Moore H; Kandel ER. 2006. Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. Neuron 49(4):603-15. PubMed: 16476668MGI: J:106982
- Kelly MP; Stein JM; Vecsey CG; Favilla C; Yang X; Bizily SF; Esposito MF; Wand G; Kanes SJ; Abel T. 2009. Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia. Mol Psychiatry 14(4):398-415, 347. PubMed: 19030002MGI: J:166114
- Kholodilov N; Kim SR; Yarygina O; Kareva T; Cho JW; Baohan A; Burke RE. 2011. Glial cell line-derived neurotrophic factor receptor-alpha1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. J Neurochem 116(4):486-98. PubMed: 21133924MGI: J:170428
- Kim TH; Zhang Y; Lecoq J; Jung JC; Li J; Zeng H; Niell CM; Schnitzer MJ. 2016. Long-Term Optical Access to an Estimated One Million Neurons in the Live Mouse Cortex. Cell Rep 17(12):3385-3394. PubMed: 28009304MGI: J:241965
- Klug JR; Mathur BN; Kash TL; Wang HD; Matthews RT; Robison AJ; Anderson ME; Deutch AY; Lovinger DM; Colbran RJ; Winder DG. 2012. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS One 7(9):e45323. PubMed: 23028932MGI: J:191787
- Kolber BJ; Boyle MP; Wieczorek L; Kelley CL; Onwuzurike CC; Nettles SA; Vogt SK; Muglia LJ. 2010. Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice. J Neurosci 30(7):2571-81. PubMed: 20164342MGI: J:157835
- Kopeikina KJ; Carlson GA; Pitstick R; Ludvigson AE; Peters A; Luebke JI; Koffie RM; Frosch MP; Hyman BT; Spires-Jones TL. 2011. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am J Pathol 179(4):2071-82. PubMed: 21854751MGI: J:176290
- Koppel J; Jimenez H; Azose M; D'Abramo C; Acker C; Buthorn J; Greenwald BS; Lewis J; Lesser M; Liu Z; Davies P. 2014. Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease. Behav Brain Res 275:27-33. PubMed: 25151619MGI: J:217067
- Krabbe S; Duda J; Schiemann J; Poetschke C; Schneider G; Kandel ER; Liss B; Roeper J; Simpson EH. 2015. Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area. Proc Natl Acad Sci U S A 112(12):E1498-506. PubMed: 25675529MGI: J:220169
- Krestel HE; Mihaljevic AL; Hoffman DA; Schneider A. 2004. Neuronal co-expression of EGFP and beta-galactosidase in mice causes neuropathology and premature death. Neurobiol Dis 17(2):310-8. PubMed: 15474368MGI: J:93090
- Krestel HE; Shimshek DR; Jensen V; Nevian T; Kim J; Geng Y; Bast T; Depaulis A; Schonig K; Schwenk F; Bujard H; Hvalby O; Sprengel R; Seeburg PH. 2004. A genetic switch for epilepsy in adult mice. J Neurosci 24(46):10568-78. PubMed: 15548671MGI: J:96556
- Kvajo M; McKellar H; Gogos JA. 2012. Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models. Neuroscience 211:136-64. PubMed: 21821099MGI: J:184660
- Langston RG; Rudenko IN; Cookson MR. 2016. The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research. Biochem J 473(3):221-32. PubMed: 26811536MGI: J:237645
- Larsen RS; Corlew RJ; Henson MA; Roberts AC; Mishina M; Watanabe M; Lipton SA; Nakanishi N; Perez-Otano I; Weinberg RJ; Philpot BD. 2011. NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity. Nat Neurosci 14(3):338-44. PubMed: 21297630MGI: J:170349
- Le TT; McGovern VL; Alwine IE; Wang X; Massoni-Laporte A; Rich MM; Burghes AH. 2011. Temporal requirement for high SMN expression in SMA mice. Hum Mol Genet 20(18):3578-91. PubMed: 21672919MGI: J:174960
- Lee AS; Duman RS; Pittenger C. 2008. A double dissociation revealing bidirectional competition between striatum and hippocampus during learning. Proc Natl Acad Sci U S A 105(44):17163-8. PubMed: 18955704MGI: J:144070
- Lee B; Cao R; Choi YS; Cho HY; Rhee AD; Hah CK; Hoyt KR; Obrietan K. 2009. The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death. J Neurochem 108(5):1251-65. PubMed: 19141071MGI: J:146168
- Lee HG; Casadesus G; Nunomura A; Zhu X; Castellani RJ; Richardson SL; Perry G; Felsher DW; Petersen RB; Smith MA. 2009. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. Am J Pathol 174(3):891-7. PubMed: 19164506MGI: J:146151
- Leo D; Gainetdinov RR. 2013. Transgenic mouse models for ADHD. Cell Tissue Res :. PubMed: 23681253MGI: J:198682
- Li T; Braunstein KE; Zhang J; Lau A; Sibener L; Deeble C; Wong PC. 2016. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nat Commun 7:12082. PubMed: 27373369MGI: J:240784
- Li YC; Kellendonk C; Simpson EH; Kandel ER; Gao WJ. 2011. D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex. (Correction) Proc Natl Acad Sci U S A 108(29):12107-12. PubMed: 21730148MGI: J:174363
- Lian H; Litvinchuk A; Chiang AC; Aithmitti N; Jankowsky JL; Zheng H. 2016. Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease. J Neurosci 36(2):577-89. PubMed: 26758846MGI: J:228864
- Lian H; Yang L; Cole A; Sun L; Chiang AC; Fowler SW; Shim DJ; Rodriguez-Rivera J; Taglialatela G; Jankowsky JL; Lu HC; Zheng H. 2015. NFkappaB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease. Neuron 85(1):101-15. PubMed: 25533482MGI: J:219343
- Licht T; Dor-Wollman T; Ben-Zvi A; Rothe G; Keshet E. 2015. Vessel maturation schedule determines vulnerability to neuronal injuries of prematurity. J Clin Invest 125(3):1319-28. PubMed: 25689256MGI: J:220538
- Licht T; Eavri R; Goshen I; Shlomai Y; Mizrahi A; Keshet E. 2010. VEGF is required for dendritogenesis of newly born olfactory bulb interneurons. Development 137(2):261-71. PubMed: 20040492MGI: J:157255
- Lim Y; Kehm VM; Lee EB; Soper JH; Li C; Trojanowski JQ; Lee VM. 2011. {alpha}-Syn Suppression Reverses Synaptic and Memory Defects in a Mouse Model of Dementia with Lewy Bodies. J Neurosci 31(27):10076-87. PubMed: 21734300MGI: J:174555
- Lim Y; Kehm VM; Li C; Trojanowski JQ; Lee VM. 2010. Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Exp Neurol 221(1):86-97. PubMed: 19833127MGI: J:156801
- Lin X; Parisiadou L; Gu XL; Wang L; Shim H; Sun L; Xie C; Long CX; Yang WJ; Ding J; Chen ZZ; Gallant PE; Tao-Cheng JH; Rudow G; Troncoso JC; Liu Z; Li Z; Cai H. 2009. Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron 64(6):807-27. PubMed: 20064389MGI: J:156512
- Lindeberg J; Mattsson R; Ebendal T. 2002. Timing the doxycycline yields different patterns of genomic recombination in brain neurons with a new inducible Cre transgene. J Neurosci Res 68(2):248-53. PubMed: 11948670MGI: J:82535
- Liu P; Paulson JB; Forster CL; Shapiro SL; Ashe KH; Zahs KR. 2015. Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique beta-Amyloid Oligomer Profile. PLoS One 10(5):e0126317. PubMed: 25946042MGI: J:235351
- Ljungberg MC; Ali YO; Zhu J; Wu CS; Oka K; Zhai RG; Lu HC. 2012. CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Hum Mol Genet 21(2):251-67. PubMed: 22027994MGI: J:179018
- Lopez ME; Klein AD; Dimbil UJ; Scott MP. 2011. Anatomically defined neuron-based rescue of neurodegenerative niemann-pick type C disorder. J Neurosci 31(12):4367-78. PubMed: 21430138MGI: J:170312
- Lopez de Armentia M; Jancic D; Olivares R; Alarcon JM; Kandel ER; Barco A. 2007. cAMP response element-binding protein-mediated gene expression increases the intrinsic excitability of CA1 pyramidal neurons. J Neurosci 27(50):13909-18. PubMed: 18077703MGI: J:130579
- Lopez-Menendez C; Gamir-Morralla A; Jurado-Arjona J; Higuero AM; Campanero MR; Ferrer I; Hernandez F; Avila J; Diaz-Guerra M; Iglesias T. 2013. Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3beta/PP1 imbalance. Hum Mol Genet 22(3):466-82. PubMed: 23118350MGI: J:191216
- Lucas JJ; Hernandez F; Gomez-Ramos P; Moran MA; Hen R; Avila J. 2001. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J 20(1-2):27-39. PubMed: 11226152MGI: J:67070
- Mack V; Burnashev N; Kaiser KM; Rozov A; Jensen V; Hvalby O; Seeburg PH; Sakmann B; Sprengel R. 2001. Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice. Science 292(5526):2501-4. PubMed: 11431570MGI: J:76021
- Maeda S; Djukic B; Taneja P; Yu GQ; Lo I; Davis A; Craft R; Guo W; Wang X; Kim D; Ponnusamy R; Gill TM; Masliah E; Mucke L. 2016. Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep 17(4):530-51. PubMed: 26931567MGI: J:233816
- Marin MA; Ziburkus J; Jankowsky J; Rasband MN. 2016. Amyloid-beta plaques disrupt axon initial segments. Exp Neurol 281:93-8. PubMed: 27109181MGI: J:236737
- Marxreiter F; Ettle B; May VE; Esmer H; Patrick C; Kragh CL; Klucken J; Winner B; Riess O; Winkler J; Masliah E; Nuber S. 2013. Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice. Neurobiol Dis 59:38-51. PubMed: 23867236MGI: J:201663
- Marxreiter F; Nuber S; Kandasamy M; Klucken J; Aigner R; Burgmayer R; Couillard-Despres S; Riess O; Winkler J; Winner B. 2009. Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein. Eur J Neurosci 29(5):879-90. PubMed: 19291219MGI: J:147049
- May VE; Nuber S; Marxreiter F; Riess O; Winner B; Winkler J. 2012. Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein. Neuroscience 222:343-55. PubMed: 22814000MGI: J:192503
- McKinney BC; Schneider JS; Schafer GL; Lowing JL; Mohan S; Zhao MX; Heng MY; Albin RL; Seasholtz AF; Akil H; Murphy GG. 2008. Decreased locomotor activity in mice expressing tTA under control of the CaMKII alpha promoter. Genes Brain Behav 7(2):203-13. PubMed: 17640289MGI: J:145601
- Melnikova T; Fromholt S; Kim H; Lee D; Xu G; Price A; Moore BD; Golde TE; Felsenstein KM; Savonenko A; Borchelt DR. 2013. Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis. J Neurosci 33(9):3765-79. PubMed: 23447589MGI: J:195259
- Menkes-Caspi N; Yamin HG; Kellner V; Spires-Jones TL; Cohen D; Stern EA. 2015. Pathological tau disrupts ongoing network activity. Neuron 85(5):959-66. PubMed: 25704951MGI: J:219856
- Messing L; Decker JM; Joseph M; Mandelkow E; Mandelkow EM. 2013. Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiol Aging 34(5):1343-54. PubMed: 23158765MGI: J:203380
- Mir S; Cai W; Andres DA. 2017. RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis. J Biol Chem 292(6):2054-2064. PubMed: 28007959MGI: J:240713
- Mocanu MM; Nissen A; Eckermann K; Khlistunova I; Biernat J; Drexler D; Petrova O; Schonig K; Bujard H; Mandelkow E; Zhou L; Rune G; Mandelkow EM. 2008. The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. J Neurosci 28(3):737-48. PubMed: 18199773MGI: J:131379
- Morozov A; Muzzio IA; Bourtchouladze R; Van-Strien N; Lapidus K; Yin D; Winder DG; Adams JP; Sweatt JD; Kandel ER. 2003. Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory. Neuron 39(2):309-25. PubMed: 12873387MGI: J:128795
- Muyllaert D; Terwel D; Kremer A; Sennvik K; Borghgraef P; Devijver H; Dewachter I; Van Leuven F. 2008. Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration. Am J Pathol 172(2):470-85. PubMed: 18202185MGI: J:131373
- Myczek K; Yeung ST; Castello N; Baglietto-Vargas D; LaFerla FM. 2014. Hippocampal adaptive response following extensive neuronal loss in an inducible transgenic mouse model. PLoS One 9(9):e106009. PubMed: 25184527MGI: J:221533
- Myeku N; Clelland CL; Emrani S; Kukushkin NV; Yu WH; Goldberg AL; Duff KE. 2016. Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nat Med 22(1):46-53. PubMed: 26692334MGI: J:233168
- Nakagawa S; Kim JE; Lee R; Malberg JE; Chen J; Steffen C; Zhang YJ; Nestler EJ; Duman RS. 2002. Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci 22(9):3673-82. PubMed: 11978843MGI: J:128620
- Nakashiba T; Young JZ; McHugh TJ; Buhl DL; Tonegawa S. 2008. Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning. Science 319(5867):1260-4. PubMed: 18218862MGI: J:131852
- Nicholls RE; Alarcon JM; Malleret G; Carroll RC; Grody M; Vronskaya S; Kandel ER. 2008. Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility. Neuron 58(1):104-17. PubMed: 18400167MGI: J:135145
- Nicholls RE; Zhang XL; Bailey CP; Conklin BR; Kandel ER; Stanton PK. 2006. mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses. Proc Natl Acad Sci U S A 103(16):6380-5. PubMed: 16606834MGI: J:109030
- Nie T; McDonough CB; Huang T; Nguyen PV; Abel T. 2007. Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memory. J Neurosci 27(38):10278-88. PubMed: 17881534MGI: J:145104
- Niewoehner B; Single FN; Hvalby O; Jensen V; Borgloh SM; Seeburg PH; Rawlins JN; Sprengel R; Bannerman DM. 2007. Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus. Eur J Neurosci 25(3):837-46. PubMed: 17313573MGI: J:119834
- Nuber S; Petrasch-Parwez E; Winner B; Winkler J; von Horsten S; Schmidt T; Boy J; Kuhn M; Nguyen HP; Teismann P; Schulz JB; Neumann M; Pichler BJ; Reischl G; Holzmann C; Schmitt I; Bornemann A; Kuhn W; Zimmermann F; Servadio A; Riess O. 2008. Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease. J Neurosci 28(10):2471-84. PubMed: 18322092MGI: J:132774
- Odeh F; Leergaard TB; Boy J; Schmidt T; Riess O; Bjaalie JG. 2011. Atlas of transgenic Tet-Off Ca2+/calmodulin-dependent protein kinase II and prion protein promoter activity in the mouse brain. Neuroimage 54(4):2603-11. PubMed: 21093594MGI: J:204506
- Paine SM; Anderson G; Bedford K; Lawler K; Mayer RJ; Lowe J; Bedford L. 2013. Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of alpha-synuclein. PLoS One 8(1):e54711. PubMed: 23382946MGI: J:195914
- Palais G; Nguyen Dinh Cat A; Friedman H; Panek-Huet N; Millet A; Tronche F; Gellen B; Mercadier JJ; Peterson A; Jaisser F. 2009. Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system. Physiol Genomics 37(2):140-6. PubMed: 19141541MGI: J:157969
- Parisiadou L; Xie C; Cho HJ; Lin X; Gu XL; Long CX; Lobbestael E; Baekelandt V; Taymans JM; Sun L; Cai H. 2009. Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. J Neurosci 29(44):13971-80. PubMed: 19890007MGI: J:154755
- Parisiadou L; Yu J; Sgobio C; Xie C; Liu G; Sun L; Gu XL; Lin X; Crowley NA; Lovinger DM; Cai H. 2014. LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nat Neurosci 17(3):367-76. PubMed: 24464040MGI: J:206832
- Pavlopoulos E; Jones S; Kosmidis S; Close M; Kim C; Kovalerchik O; Small SA; Kandel ER. 2013. Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48. Sci Transl Med 5(200):200ra115. PubMed: 23986399MGI: J:213461
- Pickrell AM; Fukui H; Wang X; Pinto M; Moraes CT. 2011. The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions. J Neurosci 31(27):9895-904. PubMed: 21734281MGI: J:174561
- Pinto M; Pickrell AM; Fukui H; Moraes CT. 2013. Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation. Neurobiol Aging 34(10):2399-407. PubMed: 23702344MGI: J:211726
- Pletnikov MV; Ayhan Y; Nikolskaia O; Xu Y; Ovanesov MV; Huang H; Mori S; Moran TH; Ross CA. 2008. Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry 13(2):173-86, 115. PubMed: 17848917MGI: J:146881
- Pogorelov VM; Nomura J; Kim J; Kannan G; Ayhan Y; Yang C; Taniguchi Y; Abazyan B; Valentine H; Krasnova IN; Kamiya A; Cadet JL; Wong DF; Pletnikov MV. 2012. Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model. Neuropharmacology 62(3):1242-51. PubMed: 21315744MGI: J:183592
- Polito VA; Li H; Martini-Stoica H; Wang B; Yang L; Xu Y; Swartzlander DB; Palmieri M; di Ronza A; Lee VM; Sardiello M; Ballabio A; Zheng H. 2014. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med 6(9):1142-60. PubMed: 25069841MGI: J:232466
- Pozueta J; Lefort R; Shelanski ML. 2013. Synaptic changes in Alzheimer's disease and its models. Neuroscience 251:51-65. PubMed: 22687952MGI: J:207068
- Pujadas L; Gruart A; Bosch C; Delgado L; Teixeira CM; Rossi D; de Lecea L; Martinez A; Delgado-Garcia JM; Soriano E. 2010. Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation. J Neurosci 30(13):4636-49. PubMed: 20357114MGI: J:159385
- Ramsden M; Kotilinek L; Forster C; Paulson J; McGowan E; SantaCruz K; Guimaraes A; Yue M; Lewis J; Carlson G; Hutton M; Ashe KH. 2005. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci 25(46):10637-47. PubMed: 16291936MGI: J:102973
- Robbins EM; Krupp AJ; Perez de Arce K; Ghosh AK; Fogel AI; Boucard A; Sudhof TC; Stein V; Biederer T. 2010. SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning. Neuron 68(5):894-906. PubMed: 21145003MGI: J:167742
- Roberts AC; Diez-Garcia J; Rodriguiz RM; Lopez IP; Lujan R; Martinez-Turrillas R; Pico E; Henson MA; Bernardo DR; Jarrett TM; Clendeninn DJ; Lopez-Mascaraque L; Feng G; Lo DC; Wesseling JF; Wetsel WC; Philpot BD; Perez-Otano I. 2009. Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. Neuron 63(3):342-56. PubMed: 19679074MGI: J:154942
- Rocher AB; Crimins JL; Amatrudo JM; Kinson MS; Todd-Brown MA; Lewis J; Luebke JI. 2010. Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs. Exp Neurol 223(2):385-93. PubMed: 19665462MGI: J:162373
- Sahara N; Perez PD; Lin WL; Dickson DW; Ren Y; Zeng H; Lewis J; Febo M. 2014. Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study. Neurobiol Aging 35(6):1364-74. PubMed: 24411290MGI: J:213888
- Sakaguchi M; Kim K; Yu LM; Hashikawa Y; Sekine Y; Okumura Y; Kawano M; Hayashi M; Kumar D; Boyden ES; McHugh TJ; Hayashi Y. 2015. Inhibiting the Activity of CA1 Hippocampal Neurons Prevents the Recall of Contextual Fear Memory in Inducible ArchT Transgenic Mice. PLoS One 10(6):e0130163. PubMed: 26075894MGI: J:237814
- Sakai N; Tsubokawa H; Matsuzaki M; Kajimoto T; Takahashi E; Ren Y; Ohmori S; Shirai Y; Matsubayashi H; Chen J; Duman RS; Kasai H; Saito N. 2004. Propagation of gammaPKC translocation along the dendrites of Purkinje cell in gammaPKC-GFP transgenic mice. Genes Cells 9(10):945-57. PubMed: 15461665MGI: J:133986
- Samuels BA; Hsueh YP; Shu T; Liang H; Tseng HC; Hong CJ; Su SC; Volker J; Neve RL; Yue DT; Tsai LH. 2007. Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 56(5):823-37. PubMed: 18054859MGI: J:169741
- Sanchis-Segura C; Jancic D; Jimenez-Minchan M; Barco A. 2009. Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine--and morphine withdrawal-related cues. Front Behav Neurosci 3:30. PubMed: 19826619MGI: J:223067
- Sano Y; Ornthanalai VG; Yamada K; Homma C; Suzuki H; Suzuki T; Murphy NP; Itohara S. 2009. X11-like protein deficiency is associated with impaired conflict resolution in mice. J Neurosci 29(18):5884-96. PubMed: 19420255MGI: J:148481
- Santacruz K; Lewis J; Spires T; Paulson J; Kotilinek L; Ingelsson M; Guimaraes A; DeTure M; Ramsden M; McGowan E; Forster C; Yue M; Orne J; Janus C; Mariash A; Kuskowski M; Hyman B; Hutton M; Ashe KH. 2005. Tau suppression in a neurodegenerative mouse model improves memory function. Science 309(5733):476-81. PubMed: 16020737MGI: J:99626
- Schirer Y; Malishkevich A; Ophir Y; Lewis J; Giladi E; Gozes I. 2014. Novel marker for the onset of frontotemporal dementia: early increase in activity-dependent neuroprotective protein (ADNP) in the face of Tau mutation. PLoS One 9(1):e87383. PubMed: 24489906MGI: J:212690
- Schmeisser MJ; Baumann B; Johannsen S; Vindedal GF; Jensen V; Hvalby OC; Sprengel R; Seither J; Maqbool A; Magnutzki A; Lattke M; Oswald F; Boeckers TM; Wirth T. 2012. IkappaB kinase/nuclear factor kappaB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling. J Neurosci 32(16):5688-703. PubMed: 22514330MGI: J:184438
- Schmidt-Strassburger U; Schips TG; Maier HJ; Kloiber K; Mannella F; Braunstein KE; Holzmann K; Ushmorov A; Liebau S; Boeckers TM; Wirth T. 2012. Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors. FASEB J 26(12):4990-5001. PubMed: 22935140MGI: J:193342
- Schonig K; Schwenk F; Rajewsky K; Bujard H. 2002. Stringent doxycycline dependent control of CRE recombinase in vivo. Nucleic Acids Res 30(23):e134. PubMed: 12466566MGI: J:81196
- Scott L; Kiss T; Kawabe TT; Hajos M. 2016. Neuronal network activity in the hippocampus of tau transgenic (Tg4510) mice. Neurobiol Aging 37:66-73. PubMed: 26610388MGI: J:234438
- Seneviratne U; Nott A; Bhat VB; Ravindra KC; Wishnok JS; Tsai LH; Tannenbaum SR. 2016. S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration. Proc Natl Acad Sci U S A 113(15):4152-7. PubMed: 27035958MGI: J:232119
- Serchov T; Clement HW; Schwarz MK; Iasevoli F; Tosh DK; Idzko M; Jacobson KA; de Bartolomeis A; Normann C; Biber K; van Calker D. 2015. Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a. Neuron 87(3):549-62. PubMed: 26247862MGI: J:227676
- Simpson EH; Morud J; Winiger V; Biezonski D; Zhu JP; Bach ME; Malleret G; Polan HJ; Ng-Evans S; Phillips PE; Kellendonk C; Kandel ER. 2014. Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum. Learn Mem 21(4):205-14. PubMed: 24639487MGI: J:225566
- Simpson EH; Winiger V; Biezonski DK; Haq I; Kandel ER; Kellendonk C. 2014. Selective overexpression of dopamine D3 receptors in the striatum disrupts motivation but not cognition. Biol Psychiatry 76(10):823-31. PubMed: 24387821MGI: J:225565
- Sorolla MA; Rodriguez-Colman MJ; Tamarit J; Tamarit J; Ortega Z; Lucas JJ; Ferrer I; Rosa J; Cabiscol E. 2010. Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism. Free Radic Biol Med 49(4):612-21. PubMed: 20639122MGI: J:162547
- Suh J; Rivest AJ; Nakashiba T; Tominaga T; Tonegawa S. 2011. Entorhinal Cortex Layer III Input to the Hippocampus Is Crucial for Temporal Association Memory. Science :. PubMed: 22052975MGI: J:178297
- Sundaram JR; Chan ES; Poore CP; Pareek TK; Cheong WF; Shui G; Tang N; Low CM; Wenk MR; Kesavapany S. 2012. Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration. J Neurosci 32(3):1020-34. PubMed: 22262900MGI: J:179887
- Sundaram JR; Poore CP; Sulaimee NH; Pareek T; Asad AB; Rajkumar R; Cheong WF; Wenk MR; Dawe GS; Chuang KH; Pant HC; Kesavapany S. 2013. Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo. J Neurosci 33(1):334-43. PubMed: 23283346MGI: J:193916
- Svenningsson P; Chergui K; Rachleff I; Flajolet M; Zhang X; Yacoubi ME; Vaugeois JM; Nomikos GG; Greengard P. 2006. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311(5757):77-80. PubMed: 16400147MGI: J:104116
- Sydow A; Van der Jeugd A; Zheng F; Ahmed T; Balschun D; Petrova O; Drexler D; Zhou L; Rune G; Mandelkow E; D'Hooge R; Alzheimer C; Mandelkow EM. 2011. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic tau mutant. J Neurosci 31(7):2511-25. PubMed: 21325519MGI: J:169532
- Tanaka KF; Matsui K; Sasaki T; Sano H; Sugio S; Fan K; Hen R; Nakai J; Yanagawa Y; Hasuwa H; Okabe M; Deisseroth K; Ikenaka K; Yamanaka A. 2012. Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system. Cell Rep 2(2):397-406. PubMed: 22854021MGI: J:186771
- Trantham-Davidson H; Vazdarjanova A; Dai R; Terry A; Bergson C. 2008. Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice. Behav Brain Res 189(2):244-9. PubMed: 18295356MGI: J:181086
- Vazdarjanova A; Bunting K; Muthusamy N; Bergson C. 2011. Calcyon upregulation in adolescence impairs response inhibition and working memory in adulthood. Mol Psychiatry 16(6):672-84. PubMed: 21403673MGI: J:181085
- Walker AK; Tripathy K; Restrepo CR; Ge G; Xu Y; Kwong LK; Trojanowski JQ; Lee VM. 2015. An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. Hum Mol Genet 24(25):7241-54. PubMed: 26476406MGI: J:226974
- Wang L; Xie C; Greggio E; Parisiadou L; Shim H; Sun L; Chandran J; Lin X; Lai C; Yang WJ; Moore DJ; Dawson TM; Dawson VL; Chiosis G; Cookson MR; Cai H. 2008. The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J Neurosci 28(13):3384-91. PubMed: 18367605MGI: J:133490
- Ward NL; Putoczki T; Mearow K; Ivanco TL; Dumont DJ. 2005. Vascular-specific growth factor angiopoietin 1 is involved in the organization of neuronal processes. J Comp Neurol 482(3):244-56. PubMed: 15690488MGI: J:95553
- Ward SM; Himmelstein DS; Ren Y; Fu Y; Yu XW; Roberts K; Binder LI; Sahara N. 2014. TOC1: a valuable tool in assessing disease progression in the rTg4510 mouse model of tauopathy. Neurobiol Dis 67:37-48. PubMed: 24631720MGI: J:213657
- Wegmann S; Maury EA; Kirk MJ; Saqran L; Roe A; DeVos SL; Nicholls S; Fan Z; Takeda S; Cagsal-Getkin O; William CM; Spires-Jones TL; Pitstick R; Carlson GA; Pooler AM; Hyman BT. 2015. Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. EMBO J 34(24):3028-41. PubMed: 26538322MGI: J:228080
- Weible AP; Schwarcz L; Wickersham IR; Deblander L; Wu H; Callaway EM; Seung HS; Kentros CG. 2010. Transgenic targeting of recombinant rabies virus reveals monosynaptic connectivity of specific neurons. J Neurosci 30(49):16509-13. PubMed: 21147990MGI: J:166740
- Wekselblatt JB; Flister ED; Piscopo DM; Niell CM. 2016. Large-scale imaging of cortical dynamics during sensory perception and behavior. J Neurophysiol :jn.01056.2015. PubMed: 26912600MGI: J:229378
- Wieczorek L; Maas JW Jr; Muglia LM; Vogt SK; Muglia LJ. 2010. Temporal and regional regulation of gene expression by calcium-stimulated adenylyl cyclase activity during fear memory. PLoS One 5(10):e13385. PubMed: 20976279MGI: J:166523
- Wiltgen BJ; Law M; Ostlund S; Mayford M; Balleine BW. 2007. The influence of Pavlovian cues on instrumental performance is mediated by CaMKII activity in the striatum. Eur J Neurosci 25(8):2491-7. PubMed: 17445244MGI: J:125036
- Wortge S; Eshkind L; Cabezas-Wallscheid N; Lakaye B; Kim J; Heck R; Abassi Y; Diken M; Sprengel R; Bockamp E. 2010. Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression. BMC Dev Biol 10:95. PubMed: 20815887MGI: J:165820
- Wu D; Qiu Y; Gao X; Yuan XB; Zhai Q. 2011. Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function. PLoS One 6(6):e21759. PubMed: 21738790MGI: J:174424
- Yamamoto A; Lucas JJ; Hen R. 2000. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease [see comments] Cell 101(1):57-66. PubMed: 10778856MGI: J:61490
- Yamasaki TR; Blurton-Jones M; Morrissette DA; Kitazawa M; Oddo S; LaFerla FM. 2007. Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci 27(44):11925-33. PubMed: 17978032MGI: J:127469
- Yasuda M; Johnson-Venkatesh EM; Zhang H; Parent JM; Sutton MA; Umemori H. 2011. Multiple forms of activity-dependent competition refine hippocampal circuits in vivo. Neuron 70(6):1128-42. PubMed: 21689599MGI: J:175245
- Yasuda M; Mayford MR. 2006. CaMKII activation in the entorhinal cortex disrupts previously encoded spatial memory. Neuron 50(2):309-18. PubMed: 16630840MGI: J:108340
- Ye X; Cai Q. 2014. Snapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons. Cell Rep 6(1):24-31. PubMed: 24373968MGI: J:207508
- Ye X; Feng T; Tammineni P; Chang Q; Jeong YY; Margolis DJ; Cai H; Kusnecov A; Cai Q. 2017. Regulation of Synaptic Amyloid-beta Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease. J Neurosci 37(10):2639-2655. PubMed: 28159908MGI: J:239680
- Yetman MJ; Jankowsky JL. 2013. Wild-type neural progenitors divide and differentiate normally in an amyloid-rich environment. J Neurosci 33(44):17335-41. PubMed: 24174666MGI: J:204201
- Yeung ST; Myczek K; Kang AP; Chabrier MA; Baglietto-Vargas D; Laferla FM. 2014. Impact of hippocampal neuronal ablation on neurogenesis and cognition in the aged brain. Neuroscience 259:214-22. PubMed: 24316470MGI: J:207913
- Yin DM; Chen YJ; Lu YS; Bean JC; Sathyamurthy A; Shen C; Liu X; Lin TW; Smith CA; Xiong WC; Mei L. 2013. Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1. Neuron 78(4):644-57. PubMed: 23719163MGI: J:201544
- Yin DM; Sun XD; Bean JC; Lin TW; Sathyamurthy A; Xiong WC; Gao TM; Chen YJ; Mei L. 2013. Regulation of spine formation by ErbB4 in PV-positive interneurons. J Neurosci 33(49):19295-303. PubMed: 24305825MGI: J:204147
- Yue M; Hanna A; Wilson J; Roder H; Janus C. 2011. Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy. Neurobiol Aging 32(4):590-603. PubMed: 19427061MGI: J:173738
- Zeng H; Horie K; Madisen L; Pavlova MN; Gragerova G; Rohde AD; Schimpf BA; Liang Y; Ojala E; Kramer F; Roth P; Slobodskaya O; Dolka I; Southon EA; Tessarollo L; Bornfeldt KE; Gragerov A; Pavlakis GN; Gaitanaris GA. 2008. An inducible and reversible mouse genetic rescue system. PLoS Genet 4(5):e1000069. PubMed: 18464897MGI: J:136987
- Zhao R; Grunke SD; Keralapurath MM; Yetman MJ; Lam A; Lee TC; Sousounis K; Jiang Y; Swing DA; Tessarollo L; Ji D; Jankowsky JL. 2016. Impaired Recall of Positional Memory following Chemogenetic Disruption of Place Field Stability. Cell Rep 16(3):793-804. PubMed: 27373150MGI: J:238589
- Zhao R; Grunke SD; Keralapurath MM; Yetman MJ; Lam A; Lee TC; Sousounis K; Jiang Y; Swing DA; Tessarollo L; Ji D; Jankowsky JL. 2016. Impaired recall of positional memory following chemogenetic disruption of place field stability Cell Rep :. MGI: J:232624
- Zhou M; Rebholz H; Brocia C; Warner-Schmidt JL; Fienberg AA; Nairn AC; Greengard P; Flajolet M. 2010. Forebrain overexpression of CK1delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD. Proc Natl Acad Sci U S A 107(9):4401-6. PubMed: 20145109MGI: J:158611
- de Calignon A; Fox LM; Pitstick R; Carlson GA; Bacskai BJ; Spires-Jones TL; Hyman BT. 2010. Caspase activation precedes and leads to tangles. Nature 464(7292):1201-4. PubMed: 20357768MGI: J:159296
- de Calignon A; Polydoro M; Suarez-Calvet M; William C; Adamowicz DH; Kopeikina KJ; Pitstick R; Sahara N; Ashe KH; Carlson GA; Spires-Jones TL; Hyman BT. 2012. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron 73(4):685-97. PubMed: 22365544MGI: J:182498