Sex-limited protein (Slp) expression in many strains is limited to males and is androgen-dependent. An additional control of sex-dependent gene expression is conferred by the regulator of sex-limitation (rsl) gene, mapped to a region on Chromosome 13 that is comprised exclusively of KRAB (Kruppel-associated box) zinc-finger protein (ZFP) genes. Females carrying rsl inappropriately express Slp. The rsl allele not only enables Slp expression in females but also increases expression in males.
|Allele Name||regulator of sex limited protein-Slp|
|Allele Synonym(s)||rslFM; rslPL; Rsl1-|
|Gene Symbol and Name||rsl, regulator of sex limited protein-Slp|
|Strain of Origin||multiple strains|
|Molecular Note||The Slp gene is normally expressed in male mice, but it is expressed in females in the strains FM, LG, NZB, and PL due to a mutation in the rsl gene(s). The rsl (regulator of sex limited protein-Slp) phenotype is attributable to mutations in both the Rsl1 and Rsl2 genes. Both a small deletion of Rsl2 and a G-to-T transversion mutation that affects transcript splicing of Rsl1 appear to affect sexually dimorphic expression of male-specific genes, although only the mutation in Rsl1 appears to cause the loss of sex-limited expression of Slp.|