B10(D2).PL(2)-rsl/J

Stock number: 003003

Description

The rsl gene controls expression of the sex-limited protein (Slp) gene.

Detailed description

Sex-limited protein (Slp) expression in many strains is limited to males and is androgen-dependent. An additional control of sex-dependent gene expression is conferred by the regulator of sex-limitation (rsl) gene, mapped to a region on Chromosome 13 that is comprised exclusively of KRAB (Kruppel-associated box) zinc-finger protein (ZFP) genes. Females carrying rsl inappropriately express Slp. The rsl allele not only enables Slp expression in females but also increases expression in males.

Allele

Symbol: rsl
Name: regulator of sex limited protein-Slp
MGI accession ID: MGI:3044189
Generation method: Spontaneous
Synonyms: rsl^FM; rsl^PL; Rsl1^-
Marker symbol: rsl
Marker name: regulator of sex limited protein-Slp
Chromosome: 13
Strain of origin: multiple strains
Molecular note: The Slp gene is normally expressed in male mice, but it is expressed in females in the strains FM, LG, NZB, and PL due to a mutation in the rsl gene(s). The rsl (regulator of sex limited protein-Slp) phenotype is attributable to mutations in both the Rsl1 and Rsl2 genes. Both a small deletion of Rsl2 and a G-to-T transversion mutation that affects transcript splicing of Rsl1 appear to affect sexually dimorphic expression of male-specific genes, although only the mutation in Rsl1 appears to cause the loss of sex-limited expression of Slp.