JAX Mouse Strain Datasheet - 002994

B6.129X1-Bax^tm1Sjk/J

Stock No:: 002994 |; Bax^-

Repository Live

Overview

Also Known As: Bax^-

Homozygous Bax^tm1Sjk mice display aberrant apoptosis with hyperplasia displayed in various tissues, including thymocytes, B cells, and cells of the reproductive organs.

Donating Investigator

Dr. Stanley J. Korsmeyer, Dana-Farber Cancer Institute

Genetic overview

Genetic Background	Generation
C57BL/6	N21+N1F9 (27-MAR-17)

Bax^tm1Sjk

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Bax	BCL2-associated X protein

View Genetics

Research Applications

Apoptosis Research
Cancer Research
Developmental Biology Research
Immunology, Inflammation and Autoimmunity Research
Reproductive Biology Research

View All Research Applications

Base Price

Starting at:

$255.00 Domestic price for female

$510.00 Domestic price for breeder pair

View Price List

Details

Detailed Description

Mice homozygous for the Bax^tm1Sjk mutation are viable but display lineage-specific aberrations in cell death. Thymocytes and B cells from homozygous mutant mice display hyperplasia. Ovaries contain unusual atretic follicles with excess granulosa cells while Bax-deficient males are infertile. There is an accumulation of atypical premeiotic germ cells and no mature haploid sperm found in seminiferous tubules. Multinucleated giant cells and dysplastic cells accompany massive cell death.

Used in conjunction with strain B6.129-Bak1^tm1Thsn/J (see Stock No. 004183), to generate the double knock-out Bak/Bax, a model for demonstrating severe defects in the regulation of apoptosis during development and tissue homeostasis.

Coat color of Bax^tm1Sjk mice
The coat color loci tyrosinase (Tyr) and pink-eyed dilution (p) are linked to the Bcl2-associated X protein (Bax) gene. According to backcross data from the Mouse Genome Database, Bax is at 23.00 cM, p is at 28.00 cM, and Tyr is at 44.00 cM on chromosome 7. The targeted disruption of the Bax gene was performed in a 129-derived RW-4 ES cell line (A^w/A^w p Tyr^c-ch/p Tyr^c) and has been backcrossed 8 generations to C57BL/6 (a/a +^p +^Tyr-c/+^p +^Tyr-c; nonagouti black). Statistically, C57BL/6J-Bax^tm1Sjk mice (Stock No. 002994) should be 99.6% C57BL/6-like at all loci not linked to the Bax gene. At the present time The Jackson Laboratory's colony of C57BL/6J-Bax^tm1Sjkmice are stillsegregating at the Tyr locus and retain the p allele from the 129 ES cell line. Thus, matings of Bax heterozygous (+/-) mice may produce progeny of varying coat color including black, white, chinchilla, light chinchilla, or grey, with all but the black mice having pink eyes. Because the potential for crossover between the p and Bax loci is small (roughly 5%), progeny that are grey in color and have pink eyes most likely are homozygous for the targeted Bax gene (-/-). However, we strongly recommend that you confirm the genotype of the mice prior to using them for research purposes. The Jackson Laboratory is continuing to backcross the Bax targeted mutation to C57BL/6J to try to eliminate the recessive 129 alleles of Tyr and p. However, in an effort to make these mice available to the research community as soon as possible we will begin distribution of the current colony. To summarize, the C57BL/6J-Bax^tm1Sjkmice (Stock No. 002994) have been backcrossed 8 generations to the C57BL/6J inbred strain. However, because of coat color genes linked to the Bax mutation breeder pairs supplied by The Jackson Laboratory may produce progeny of varying coat color.

Development

A Bax targeting vector substituted PGK-Neo for exons 2 through 5, deleting BH1 and BH2 and the capacity for a functional protein.

Control Suggestions

Wild-type from the colony
000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Knudson CM; Tung KS; Tourtellotte WG; Brown GA; Korsmeyer SJ. 1995. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270(5233):96-9. PubMed: 7569956 MGI: J:29253

View All References

Genetics

Bax^tm1Sjk

Allele Symbol: Bax^tm1Sjk

Allele Name	targeted mutation 1, Stanley J Korsmeyer
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	Bax1; Bax^-
Gene Symbol and Name	Bax, BCL2-associated X protein
Gene Synonym(s)	BCL2L4
Strain of Origin	129X1/SvJ
Chromosome	7
Molecular Note	A neomycin selection cassette replaced exons 2 through 4 and part of exon 5, which encode sequences that correspond to the two BCL2 homology domains BH1 and BH2. Immunoblots did not detect the endcoded protein in tissue lysates derived from homozygous mice.
Mutations Made By	Dr. Stanley Korsmeyer, Dana-Farber Cancer Institute

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Bax^tm1Sjk related

Apoptosis Research
- Endogenous Regulators
Cancer Research
- Genes Regulating Growth and Proliferation
Developmental Biology Research
- Internal/Organ Defects
  - gonads
Immunology, Inflammation and Autoimmunity Research
- Intracellular Signaling Molecules
Reproductive Biology Research
- Developmental Defects Affecting Gonads
- Fertility Defects

Mammalian Phenotype Terms by Genotype

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
B6.129X1-Bax^tm1Sjk/J

cellular phenotype

azoospermia

reproductive system phenotype

abnormal seminiferous tubule morphology
- some tubules have an accumulation of early germ cells while others have fewer germ cells than normal
- the spermatogonia layer is thicker than in wild-type being up to 3 cell layers thick

abnormal spermatogenesis
- at P15 the number of germ cells in the testis is increased and these are mostly c-Kit+ early germ cells, but in adult males the number of germ cells is decreased by up to 10-fold compared to wild-type

arrest of male meiosis
- arrests before the completion of meiosis in the preleptotene spermatocyte stage

azoospermia

decreased testis weight
- in adults testes weigh about 60% that of wild-type

male infertility
- males but not females are sterile

growth/size/body region phenotype

decreased body weight
- seen in about 50% of mice

nervous system phenotype

nervous system phenotype
- cultured enteric neurons from Bax-deficient embryos that are GDNF-deprived show no significant differences in survival relative to enteric neurons from conditionally-inactivated Gfra1-null mice

endocrine/exocrine gland phenotype

abnormal seminiferous tubule morphology
- some tubules have an accumulation of early germ cells while others have fewer germ cells than normal
- the spermatogonia layer is thicker than in wild-type being up to 3 cell layers thick

decreased testis weight
- in adults testes weigh about 60% that of wild-type

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Bax^tm1Sjk/Bax⁺
involves: 129X1/SvJ

nervous system phenotype

abnormal sympathetic neuron morphology
- cultures of sympathetic neurons grown in the presence of NGF before being deprived of NGF, die with slower kinetics than wild-type, such that after 8 days, 14% of neurons remain viable compared to none in controls

increased motor neuron number
- modest 13% increase in the total number of facial motor neurons at 4 weeks of age relative to wild-type

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

nervous system phenotype

abnormal axon extension
- neurite outgrowth is significantly less than that of Isl1^tm1(cre)Cos Mapt^{tm1(Ewsr1/Etv4)Arbr} heterozygotes with or without treatment with neurotrphin-3

abnormal dorsal root ganglion morphology
- dorsal root ganglia neurons survive without neurotrophic factors

increased sensory neuron number
- apoptosis rates are decreased resulting in increased number of neurons in the lumbar dorsal root ganglia (170% of wild-type numbers)

cellular phenotype

abnormal axon extension
- neurite outgrowth is significantly less than that of Isl1^tm1(cre)Cos Mapt^{tm1(Ewsr1/Etv4)Arbr} heterozygotes with or without treatment with neurotrphin-3

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129X1/SvJ

endocrine/exocrine gland phenotype

abnormal ovarian follicle morphology
- atretic follicles with excess granulosa cells

abnormal seminiferous tubule morphology
- disordered

increased thymocyte number
- 1.6 fold increase in thymocyte number relative to wild-type
- normal distribution of maturational subsets (CD4-CD8-, CD4+CD8+, CD4+, CD8+ cells)

hematopoietic system phenotype

enlarged spleen

increased B cell number

increased thymocyte number
- 1.6 fold increase in thymocyte number relative to wild-type
- normal distribution of maturational subsets (CD4-CD8-, CD4+CD8+, CD4+, CD8+ cells)

immune system phenotype

enlarged spleen

increased B cell number

increased thymocyte number
- 1.6 fold increase in thymocyte number relative to wild-type
- normal distribution of maturational subsets (CD4-CD8-, CD4+CD8+, CD4+, CD8+ cells)

reproductive system phenotype

abnormal male germ cell apoptosis
- increased male germ cell apoptosis

abnormal ovarian follicle morphology
- atretic follicles with excess granulosa cells

abnormal seminiferous tubule morphology
- disordered

arrest of spermatogenesis
- accumulation of premeiotic germ cells

azoospermia
- absence of sperm in the epididymis and vas deferens

male infertility

nervous system phenotype

abnormal facial motor nucleus morphology
- mutants exhibit a large reduction in motor neuron death in the facial nucleus following neonatal axotomy compared to wild-type

abnormal phrenic nerve morphology
- the phrenic nerve is thicker in mutants, however neuromuscular synapses were normal

abnormal proprioceptive neuron morphology
- about 30% of pSNs in the rostral lumbar DRG have cell body diameters in the wild-type range, with 70% having smaller somatic diameters

abnormal superior cervical ganglion morphology
- superior cervical ganglion of neonates contains 2.5 and 1.8 times more neurons than wild-type and heterozygous ganglia, respectively

abnormal sympathetic neuron morphology
- sympathetic neurons from superior cervical ganglion show a dramatic reduction of death after trophic factor (NGF) deprivation

decreased neuron apoptosis
- developmental sympathetic and motor neuronal death is reduced

increased motor neuron number
- contralateral nonaxotomized facial nucleus shows a 51% increase in neuronal number relative to wild-type at 4 weeks of age
- mutants display an increase in the number of small- to medium-sized motor neurons

increased sensory neuron number
- number of proprioceptive sensory neurons (pSNs) is increased by 2-fold compared to wild-type controls

nervous system phenotype
- mice exhibit normal mammary gland innervation

cellular phenotype

abnormal male germ cell apoptosis
- increased male germ cell apoptosis

azoospermia
- absence of sperm in the epididymis and vas deferens

decreased neuron apoptosis
- developmental sympathetic and motor neuronal death is reduced

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129X1/SvJ * C57BL/6

endocrine/exocrine gland phenotype

abnormal ovarian folliculogenesis
- follicles persisted in aged females (20 to 22 months old)
- increased number of follicles observed at 42 days
- reduced incidence of atresia of primordial and primary follicles relative to wild-type

increased mature ovarian follicle number
- increased number of follicles observed at 42 days of age
- persistence of hundreds of follicles of all developmental stages in aged females (20 to 22 months old)

nervous system phenotype

abnormal dorsal root ganglion morphology
- the number of dorsal root ganglia neurons in L4 is increased relative to in wild-type mice

reproductive system phenotype

abnormal ovarian folliculogenesis
- follicles persisted in aged females (20 to 22 months old)
- increased number of follicles observed at 42 days
- reduced incidence of atresia of primordial and primary follicles relative to wild-type

increased mature ovarian follicle number
- increased number of follicles observed at 42 days of age
- persistence of hundreds of follicles of all developmental stages in aged females (20 to 22 months old)

uterus hypertrophy
- ovarian steroid-driven uternine hypertrophy is observed in aged females (20 to 22 months old)

The following phenotype relates to a compound genotype created using this strain

Genotype: Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm1Sjk
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6

mortality/aging

neonatal lethality, incomplete penetrance
- majority die within 48 hours of birth, although some survive to adulthood

homeostasis/metabolism phenotype

decreased physiological sensitivity to xenobiotic
- thymocytes are resistant to treatment with etoposide, a chemotherapeutic agent that normally induces cell death

limbs/digits/tail phenotype

interdigital webbing
- mutants retain interdigital webs on both fore and rear paws

reproductive system phenotype

vagina atresia
- seen in all adult females

behavior/neurological phenotype

circling
- display circling behavior when exposed to external stress

seizures
- stress-induced seizure activity

hearing/vestibular/ear phenotype

abnormal hearing physiology
- unresponsive to auditory stimuli

hematopoietic system phenotype

abnormal B cell morphology
- B220+ B cells present in the lymph node and spleen are skewed toward a B220^brightIgD- phenotype, indicating an increase in the number of class-switched or memory B cells

abnormal T cell morphology
- T cells that accumulate in mutants are skewed toward a memory cell phenotype

abnormal definitive hematopoiesis
- hematopoietic colony assays show an increase in the number of myeloid colony forming units and a mild increase in erythroid and megakaryocyte colony forming units

abnormal splenocyte physiology
- isolated splenocytes cultured in suspension show enhanced survival

anemia
- mild anemia

enlarged spleen

increased leukocyte cell number

increased lymphocyte cell number
- increases within the circulation and the peripheral lymphoid organs
- lymphocytic infiltration is seen in parenchymal organs, liver, and kidney

increased spleen red pulp amount
- expanded red pulp contains a large increase in the number of plasma cells and histiocytes

increased spleen white pulp amount
- pronounced hyperplasia

thrombocytopenia

immune system phenotype

abnormal B cell morphology
- B220+ B cells present in the lymph node and spleen are skewed toward a B220^brightIgD- phenotype, indicating an increase in the number of class-switched or memory B cells

abnormal T cell morphology
- T cells that accumulate in mutants are skewed toward a memory cell phenotype

abnormal splenocyte physiology
- isolated splenocytes cultured in suspension show enhanced survival

enlarged lymph nodes

enlarged spleen

increased leukocyte cell number

increased lymphocyte cell number
- increases within the circulation and the peripheral lymphoid organs
- lymphocytic infiltration is seen in parenchymal organs, liver, and kidney

increased spleen red pulp amount
- expanded red pulp contains a large increase in the number of plasma cells and histiocytes

increased spleen white pulp amount
- pronounced hyperplasia

nervous system phenotype

abnormal brain morphology
- increase in the number of neurons in multiple regions of the brain
- large accumulation of small neuronal cells (neural stem cells) with dense chromatin staining in the periventricular region

increased brain size

increased neuron number
- in multiple regions of the brain

seizures
- stress-induced seizure activity

cellular phenotype

decreased cellular sensitivity to gamma-irradiation
- thymocytes show enhanced survival compared to wild-type when exposed to gamma irradiation

References

Knudson CM; Tung KS; Tourtellotte WG; Brown GA; Korsmeyer SJ. 1995. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270(5233):96-9. PubMed: 7569956 MGI: J:29253

Additional References

Forger NG; Rosen GJ; Waters EM; Jacob D; Simerly RB; de Vries GJ. 2004. Deletion of Bax eliminates sex differences in the mouse forebrain. Proc Natl Acad Sci U S A 101(37):13666-71. PubMed: 15342910 MGI: J:92614
Khaled AR; Li WQ; Huang J; Fry TJ; Khaled AS; Mackall CL; Muegge K; Young HA; Durum SK. 2002. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity 17(5):561-73. PubMed: 12433363 MGI: J:93139
Knudson CM; Korsmeyer SJ. 1997. Bcl-2 and Bax function independently to regulate cell death. Nat Genet 16(4):358-63. PubMed: 9241272 MGI: J:42051
Lu YP; Lou YR; Peng QY; Xie JG; Conney AH. 2004. Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice. Cancer Res 64(14):5020-7. PubMed: 15256477 MGI: J:91506
Yin C; Knudson CM; Korsmeyer SJ; Van Dyke T. 1997. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385(6617):637-40. PubMed: 9024662 MGI: J:38331

Additional - Bax^tm1Sjk related

Abdo H; Li L; Lallemend F; Bachy I; Xu XJ; Rice FL; Ernfors P. 2011. Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci 34(10):1529-41. PubMed: 22103411 MGI: J:184160
Adlaf EW; Vaden RJ; Niver AJ; Manuel AF; Onyilo VC; Araujo MT; Dieni CV; Vo HT; King GD; Wadiche JI; Overstreet-Wadiche L. 2017. Adult-born neurons modify excitatory synaptic transmission to existing neurons. Elife 6:. PubMed: 28135190 MGI: J:240945
Alton M; Taketo T. 2007. Switch from BAX-dependent to BAX-independent germ cell loss during the development of fetal mouse ovaries. J Cell Sci 120(Pt 3):417-24. PubMed: 17213335 MGI: J:120767
Anderson MJ; Schimmang T; Lewandoski M. 2016. An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. PLoS Genet 12(5):e1006018. PubMed: 27144312 MGI: J:232560
Armstrong A; Ryu YK; Chieco D; Kuruvilla R. 2011. Frizzled3 Is Required for Neurogenesis and Target Innervation during Sympathetic Nervous System Development. J Neurosci 31(7):2371-81. PubMed: 21325504 MGI: J:169444
Bailey DP; Kashyap M; Bouton LA; Murray PJ; Ryan JJ. 2006. Interleukin-10 induces apoptosis in developing mast cells and macrophages. J Leukoc Biol 80(3):581-9. PubMed: 16829633 MGI: J:112579
Baines CP; Kaiser RA; Sheiko T; Craigen WJ; Molkentin JD. 2007. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 9(5):550-5. PubMed: 17417626 MGI: J:129616
Barone MC; Desouza LA; Freeman RS. 2008. Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity. J Neurochem 106(2):734-45. PubMed: 18419764 MGI: J:139389
Ben-Zvi A; Manor O; Schachner M; Yaron A; Tessier-Lavigne M; Behar O. 2008. The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development. J Neurosci 28(47):12427-32. PubMed: 19020035 MGI: J:142362
Ben-Zvi A; Sweetat S; Behar O. 2013. Elimination of aberrant DRG circuitries in Sema3A mutant mice leads to extensive neuronal deficits. PLoS One 8(7):e70085. PubMed: 23922915 MGI: J:204365
Berens HM; Tyler KL. 2011. The pro-apoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis. J Virol :. PubMed: 21307199 MGI: J:168899
Bernal NP; Stehr W; Coyle R; Erwin CR; Warner BW. 2006. Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice. Gastroenterology 130(2):412-23. PubMed: 16472596 MGI: J:124922
Bouilloux F; Thireau J; Venteo S; Farah C; Karam S; Dauvilliers Y; Valmier J; Copeland NG; Jenkins NA; Richard S; Marmigere F. 2016. Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. Elife 5:. PubMed: 26857994 MGI: J:230425
Bruce FM; Brown S; Smith JN; Fuerst PG; Erskine L. 2017. DSCAM promotes axon fasciculation and growth in the developing optic pathway. Proc Natl Acad Sci U S A 114(7):1702-1707. PubMed: 28137836 MGI: J:240943
Bruckheimer EM; Cho S; Brisbay S; Johnson DJ; Gingrich JR; Greenberg N; McDonnell TJ. 2000. The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo. Oncogene 19(20):2404-12. PubMed: 10828882 MGI: J:62297
Buss RR; Gould TW; Ma J; Vinsant S; Prevette D; Winseck A; Toops KA; Hammarback JA; Smith TL; Oppenheim RW. 2006. Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle. J Neurosci 26(52):13413-27. PubMed: 17192424 MGI: J:117220
Bustamante-Marin XM; Cook MS; Gooding J; Newgard C; Capel B. 2015. Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites. Biol Reprod 93(3):78. PubMed: 26224005 MGI: J:226269
Chang MY; Sun W; Ochiai W; Nakashima K; Kim SY; Park CH; Kang JS; Shim JW; Jo AY; Kang CS; Lee YS; Kim JS; Lee SH. 2007. Bcl-XL/Bax proteins direct the fate of embryonic cortical precursor cells. Mol Cell Biol 27(12):4293-305. PubMed: 17438128 MGI: J:122346
Chao JR; Parganas E; Boyd K; Hong CY; Opferman JT; Ihle JN. 2008. Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature 452(7183):98-102. PubMed: 18288109 MGI: J:132627
Chavez-Reyes A; Parant JM; Amelse LL; de Oca Luna RM; Korsmeyer SJ; Lozano G. 2003. Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Res 63(24):8664-9. PubMed: 14695178 MGI: J:87065
Chen HC; Kanai M; Inoue-Yamauchi A; Tu HC; Huang Y; Ren D; Kim H; Takeda S; Reyna DE; Chan PM; Ganesan YT; Liao CP; Gavathiotis E; Hsieh JJ; Cheng EH. 2015. An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nat Cell Biol 17(10):1270-81. PubMed: 26344567 MGI: J:227510
Chen L; Faire M; Kissner MD; Laird DJ. 2013. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet 22(2):313-27. PubMed: 23077213 MGI: J:191131
Chen WV; Alvarez FJ; Lefebvre JL; Friedman B; Nwakeze C; Geiman E; Smith C; Thu CA; Tapia JC; Tasic B; Sanes JR; Maniatis T. 2012. Functional significance of isoform diversification in the protocadherin gamma gene cluster. Neuron 75(3):402-9. PubMed: 22884324 MGI: J:188341
Cheung EC; Melanson-Drapeau L; Cregan SP; Vanderluit JL; Ferguson KL; McIntosh WC; Park DS; Bennett SA; Slack RS. 2005. Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. J Neurosci 25(6):1324-34. PubMed: 15703386 MGI: J:98103
Chi MM; Pingsterhaus J; Carayannopoulos M; Moley KH. 2000. Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst J Biol Chem 275(51):40252-7. PubMed: 10995754 MGI: J:66414
Chi MM; Schlein AL; Moley KH. 2000. High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the IGF-1 receptor. Endocrinology 141(12):4784-92. PubMed: 11108294 MGI: J:115385
Choi S; Chen Z; Tang LH; Fang Y; Shin SJ; Panarelli NC; Chen YT; Li Y; Jiang X; Du YC. 2016. Bcl-xL promotes metastasis independent of its anti-apoptotic activity. Nat Commun 7:10384. PubMed: 26785948 MGI: J:235886
Chong MJ; Murray MR; Gosink EC; Russell HR; Srinivasan A; Kapsetaki M; Korsmeyer SJ; McKinnon PJ. 2000. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc Natl Acad Sci U S A 97(2):889-94. PubMed: 10639175 MGI: J:59934
Cleland MM; Norris KL; Karbowski M; Wang C; Suen DF; Jiao S; George NM; Luo X; Li Z; Youle RJ. 2011. Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ 18(2):235-47. PubMed: 20671748 MGI: J:186336
Clemente EJ; Furlong RA; Loveland KL; Affara NA. 2006. Gene expression study in the juvenile mouse testis: identification of stage-specific molecular pathways during spermatogenesis. Mamm Genome 17(9):956-75. PubMed: 16964443 MGI: J:112872
Cook MS; Coveney D; Batchvarov I; Nadeau JH; Capel B. 2009. BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. Dev Biol 328(2):377-83. PubMed: 19389346 MGI: J:149469
Cook MS; Munger SC; Nadeau JH; Capel B. 2011. Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. Development 138(1):23-32. PubMed: 21115610 MGI: J:167041
Coulpier M; Messiaen S; Hamel R; Fernandez de Marco M; Lilin T; Eloit M. 2006. Bax deletion does not protect neurons from BSE-induced death. Neurobiol Dis 23(3):603-11. PubMed: 16854590 MGI: J:147030
Coultas L; Bouillet P; Loveland KL; Meachem S; Perlman H; Adams JM; Strasser A. 2005. Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis. EMBO J 24(22):3963-73. PubMed: 16270031 MGI: J:103605
Crowther AJ; Gama V; Bevilacqua A; Chang SX; Yuan H; Deshmukh M; Gershon TR. 2013. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci 33(46):18098-108. PubMed: 24227720 MGI: J:204171
D'Orsi B; Bonner H; Tuffy LP; Dussmann H; Woods I; Courtney MJ; Ward MW; Prehn JH. 2012. Calpains are downstream effectors of bax-dependent excitotoxic apoptosis. J Neurosci 32(5):1847-58. PubMed: 22302823 MGI: J:181340
D'Orsi B; Engel T; Pfeiffer S; Nandi S; Kaufmann T; Henshall DC; Prehn JH. 2016. Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury. J Neurosci 36(16):4564-78. PubMed: 27098698 MGI: J:235305
D'Orsi B; Kilbride SM; Chen G; Perez Alvarez S; Bonner HP; Pfeiffer S; Plesnila N; Engel T; Henshall DC; Dussmann H; Prehn JH. 2015. Bax regulates neuronal Ca2+ homeostasis. J Neurosci 35(4):1706-22. PubMed: 25632145 MGI: J:218973
Dansen TB; Whitfield J; Rostker F; Brown-Swigart L; Evan GI. 2006. Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo. J Biol Chem 281(16):10890-5. PubMed: 16464852 MGI: J:108676
Dargusch R; Piasecki D; Tan S; Liu Y; Schubert D. 2001. The role of Bax in glutamate-induced nerve cell death. J Neurochem 76(1):295-301. PubMed: 11146002 MGI: J:68970
Deckwerth TL; Easton RM; Knudson CM; Korsmeyer SJ; Johnson EM Jr. 1998. Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. Exp Neurol 152(1):150-62. PubMed: 9682022 MGI: J:179272
Deckwerth TL; Elliott JL; Knudson CM; Johnson EM Jr; Snider WD; Korsmeyer SJ. 1996. BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17(3):401-11. PubMed: 8816704 MGI: J:35372
Degenhardt K; Sundararajan R; Lindsten T; Thompson C; White E. 2002. Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem 277(16):14127-34. PubMed: 11836241 MGI: J:76058
Dejean LM; Martinez-Caballero S; Guo L; Hughes C; Teijido O; Ducret T; Ichas F; Korsmeyer SJ; Antonsson B; Jonas EA; Kinnally KW. 2005. Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell 16(5):2424-32. PubMed: 15772159 MGI: J:100217
Deppmann CD; Mihalas S; Sharma N; Lonze BE; Niebur E; Ginty DD. 2008. A model for neuronal competition during development. Science 320(5874):369-73. PubMed: 18323418 MGI: J:133953
Dierks C; Grbic J; Zirlik K; Beigi R; Englund NP; Guo GR; Veelken H; Engelhardt M; Mertelsmann R; Kelleher JF; Schultz P; Warmuth M. 2007. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nat Med 13(8):944-51. PubMed: 17632527 MGI: J:126550
Doan PL; Himburg HA; Helms K; Russell JL; Fixsen E; Quarmyne M; Harris JR; Deoliviera D; Sullivan JM; Chao NJ; Kirsch DG; Chute JP. 2013. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med 19(3):295-304. PubMed: 23377280 MGI: J:196315
Doan PL; Russell JL; Himburg HA; Helms K; Harris JR; Lucas J; Holshausen KC; Meadows SK; Daher P; Jeffords LB; Chao NJ; Kirsch DG; Chute JP. 2013. Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. Stem Cells 31(2):327-37. PubMed: 23132593 MGI: J:194696
Dominov JA; Kravetz AJ; Ardelt M; Kostek CA; Beermann ML; Miller JB. 2005. Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice. Hum Mol Genet 14(8):1029-40. PubMed: 15757977 MGI: J:98004
Dong H; Fazzaro A; Xiang C; Korsmeyer SJ; Jacquin MF; McDonald JW. 2003. Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration. J Neurosci 23(25):8682-91. PubMed: 14507967 MGI: J:85750
Doughty ML; De Jager PL; Korsmeyer SJ; Heintz N. 2000. Neurodegeneration in Lurcher mice occurs via multiple cell death pathways. J Neurosci 20(10):3687-94. PubMed: 10804210 MGI: J:62117
Dowling MR; Josefsson EC; Henley KJ; Hodgkin PD; Kile BT. 2010. Platelet senescence is regulated by an internal timer, not damage inflicted by hits. Blood 116(10):1776-8. PubMed: 20530288 MGI: J:164520
Duckworth CA; Abuderman AA; Burkitt MD; Williams JM; O'Reilly LA; Pritchard DM. 2015. bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice. Am J Physiol Gastrointest Liver Physiol 309(6):G420-30. PubMed: 26159699 MGI: J:228768
Duckworth CA; Pritchard DM. 2009. Suppression of apoptosis, crypt hyperplasia, and altered differentiation in the colonic epithelia of bak-null mice. Gastroenterology 136(3):943-52. PubMed: 19185578 MGI: J:146852
Dunkle A; Dzhagalov I; He YW. 2010. Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2. Cell Death Differ 17(6):994-1002. PubMed: 20057504 MGI: J:186374
Eblaghie MC; Reedy M; Oliver T; Mishina Y; Hogan BL. 2006. Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. Dev Biol 291(1):67-82. PubMed: 16414041 MGI: J:106392
Eischen CM; Rehg JE; Korsmeyer SJ; Cleveland JL. 2002. Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice. Cancer Res 62(7):2184-91. PubMed: 11929842 MGI: J:75877
Eischen CM; Roussel MF; Korsmeyer SJ; Cleveland JL. 2001. Bax Loss Impairs Myc-Induced Apoptosis and Circumvents the Selection of p53 Mutations during Myc-Mediated Lymphomagenesis. Mol Cell Biol 21(22):7653-62. PubMed: 11604501 MGI: J:72281
Fan H; Favero M; Vogel MW. 2001. Elimination of Bax expression in mice increases cerebellar purkinje cell numbers but not the number of granule cells. J Comp Neurol 436(1):82-91. PubMed: 11413548 MGI: J:111106
Fan H; Stefkova J; El-Dahr SS. 2006. Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway. Am J Physiol Renal Physiol 291(3):F670-82. PubMed: 16571598 MGI: J:111678
Ferrer PE; Frederick P; Gulbis JM; Dewson G; Kluck RM. 2012. Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function. PLoS One 7(3):e31510. PubMed: 22442658 MGI: J:224209
Fleming MS; Li JJ; Ramos D; Li T; Talmage DA; Abe SI; Arber S; Luo W. 2016. A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles. J Neurosci 36(40):10337-10355. PubMed: 27707970 MGI: J:235934
Fontanini A; Foti C; Potu H; Crivellato E; Maestro R; Bernardi P; Demarchi F; Brancolini C. 2009. The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB. J Biol Chem 284(13):8369-81. PubMed: 19139105 MGI: J:148618
Forger NG; Rosen GJ; Waters EM; Jacob D; Simerly RB; de Vries GJ. 2004. Deletion of Bax eliminates sex differences in the mouse forebrain. Proc Natl Acad Sci U S A 101(37):13666-71. PubMed: 15342910 MGI: J:92614
Fuerst PG; Bruce F; Tian M; Wei W; Elstrott J; Feller MB; Erskine L; Singer JH; Burgess RW. 2009. DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina. Neuron 64(4):484-97. PubMed: 19945391 MGI: J:155397
Furlan A; Lubke M; Adameyko I; Lallemend F; Ernfors P. 2013. The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification. EMBO J 32(11):1613-25. PubMed: 23591430 MGI: J:198834
Garcia I; Crowther AJ; Gama V; Ryan Miller C; Deshmukh M; Gershon TR. 2013. Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation. Oncogene 32(18):2304-14. PubMed: 22710714 MGI: J:198027
Garrison SP; Phillips DC; Jeffers JR; Chipuk JE; Parsons MJ; Rehg JE; Opferman JT; Green DR; Zambetti GP. 2012. Genetically defining the mechanism of Puma- and Bim-induced apoptosis. Cell Death Differ 19(4):642-9. PubMed: 22015606 MGI: J:203075
Gavalda N; Perez-Navarro E; Garcia-Martinez JM; Marco S; Benito A; Alberch J. 2008. Bax deficiency promotes an up-regulation of Bim(EL) and Bak during striatal and cortical postnatal development, and after excitotoxic injury. Mol Cell Neurosci 37(4):663-72. PubMed: 18272391 MGI: J:135298
Genc B; Ozdinler PH; Mendoza AE; Erzurumlu RS. 2004. A chemoattractant role for NT-3 in proprioceptive axon guidance. PLoS Biol 2(12):e403. PubMed: 15550985 MGI: J:97779
Geng Y; Walls KC; Ghosh AP; Akhtar RS; Klocke BJ; Roth KA. 2010. Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis. J Histochem Cytochem 58(3):265-75. PubMed: 19901272 MGI: J:160504
Gianino S; Grider JR; Cresswell J; Enomoto H; Heuckeroth RO. 2003. GDNF availability determines enteric neuron number by controlling precursor proliferation. Development 130(10):2187-98. PubMed: 12668632 MGI: J:82456
Girgenrath M; Dominov JA; Kostek CA; Miller JB. 2004. Inhibition of apoptosis improves outcome in a model of congenital muscular dystrophy. J Clin Invest 114(11):1635-9. PubMed: 15578095 MGI: J:94431
Glebova NO; Ginty DD. 2004. Heterogeneous requirement of NGF for sympathetic target innervation in vivo. J Neurosci 24(3):743-51. PubMed: 14736860 MGI: J:87702
Gould TW; Buss RR; Vinsant S; Prevette D; Sun W; Knudson CM; Milligan CE; Oppenheim RW. 2006. Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J Neurosci 26(34):8774-86. PubMed: 16928866 MGI: J:111890
Gray DH; Kupresanin F; Berzins SP; Herold MJ; O'Reilly LA; Bouillet P; Strasser A. 2012. The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens. Immunity 37(3):451-62. PubMed: 22960223 MGI: J:187669
Greenfeld CR; Babus JK; Furth PA; Marion S; Hoyer PB; Flaws JA. 2007. BAX is involved in regulating follicular growth, but is dispensable for follicle atresia in adult mouse ovaries. Reproduction 133(1):107-116. PubMed: 17244737 MGI: J:117770
Greenfeld CR; Pepling ME; Babus JK; Furth PA; Flaws JA. 2007. BAX regulates follicular endowment in mice. Reproduction 133(5):865-76. PubMed: 17616717 MGI: J:122810
Gruber JJ; Zatechka DS; Sabin LR; Yong J; Lum JJ; Kong M; Zong WX; Zhang Z; Lau CK; Rawlings J; Cherry S; Ihle JN; Dreyfuss G; Thompson CB. 2009. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell 138(2):328-39. PubMed: 19632182 MGI: J:152729
Gumy LF; Bampton ET; Tolkovsky AM. 2008. Hyperglycaemia inhibits Schwann cell proliferation and migration and restricts regeneration of axons and Schwann cells from adult murine DRG. Mol Cell Neurosci 37(2):298-311. PubMed: 18024075 MGI: J:132600
Guo H; Hellard DT; Huang L; Katz DM. 2005. Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor. Eur J Neurosci 21(7):2019-23. PubMed: 15869495 MGI: J:101073
Guo T; Mandai K; Condie BG; Wickramasinghe SR; Capecchi MR; Ginty DD. 2011. An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. Nat Neurosci 14(1):31-6. PubMed: 21151121 MGI: J:170402
Hahn P; Lindsten T; Lyubarsky A; Ying GS; Pugh EN Jr; Thompson CB; Dunaief JL. 2004. Deficiency of Bax and Bak protects photoreceptors from light damage in vivo. Cell Death Differ 11(11):1192-7. PubMed: 15272317 MGI: J:134629
Hahn P; Lindsten T; Tolentino M; Thompson CB; Bennett J; Dunaief JL. 2005. Persistent fetal ocular vasculature in mice deficient in bax and bak. Arch Ophthalmol 123(6):797-802. PubMed: 15955981 MGI: J:115735
Hamann S; Schorderet DF; Cottet S. 2009. Bax-induced apoptosis in Leber's congenital amaurosis: a dual role in rod and cone degeneration. PLoS One 4(8):e6616. PubMed: 19672311 MGI: J:152468
He H; Hershberger PA; McCarthy SA. 1998. Characterization of a novel Bax-associated protein expressed in hemopoietic tissues and regulated during thymocyte apoptosis. J Immunol 161(3):1169-75. PubMed: 9686576 MGI: J:119202
Hellard D; Brosenitsch T; Fritzsch B; Katz DM. 2004. Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice. Dev Biol 275(1):34-43. PubMed: 15464571 MGI: J:94276
Hetz C; Bernasconi P; Fisher J; Lee AH; Bassik MC; Antonsson B; Brandt GS; Iwakoshi NN; Schinzel A; Glimcher LH; Korsmeyer SJ. 2006. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312(5773):572-6. PubMed: 16645094 MGI: J:108337
Hippenmeyer S; Vrieseling E; Sigrist M; Portmann T; Laengle C; Ladle DR; Arber S. 2005. A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol 3(5):e159. PubMed: 15836427 MGI: J:100886
Hochhauser E; Kivity S; Offen D; Maulik N; Otani H; Barhum Y; Pannet H; Shneyvays V; Shainberg A; Goldshtaub V; Tobar A; Vidne BA. 2003. Bax ablation protects against myocardial ischemia-reperfusion injury in transgenic mice. Am J Physiol Heart Circ Physiol 284(6):H2351-9. PubMed: 12742833 MGI: J:83909
Holmes MM; McCutcheon J; Forger NG. 2009. Sex differences in NeuN- and androgen receptor-positive cells in the bed nucleus of the stria terminalis are due to Bax-dependent cell death. Neuroscience 158(4):1251-6. PubMed: 19059313 MGI: J:149001
Holmes MM; Niel L; Anyan JJ; Griffith AT; Monks DA; Forger NG. 2011. Effects of Bax gene deletion on social behaviors and neural response to olfactory cues in mice. Eur J Neurosci 34(9):1492-9. PubMed: 22034980 MGI: J:183175
Honma Y; Kawano M; Kohsaka S; Ogawa M. 2010. Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret. Development 137(14):2319-28. PubMed: 20534675 MGI: J:161851
Howell GR; Libby RT; Jakobs TC; Smith RS; Phalan FC; Barter JW; Barbay JM; Marchant JK; Mahesh N; Porciatti V; Whitmore AV; Masland RH; John SW. 2007. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol 179(7):1523-37. PubMed: 18158332 MGI: J:131073
Hua ZL; Smallwood PM; Nathans J. 2013. Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons. Elife 2:e01482. PubMed: 24347548 MGI: J:207894
Huang S; O'Donovan KJ; Turner EE; Zhong J; Ginty DD. 2015. Extrinsic and intrinsic signals converge on the Runx1/CBFbeta transcription factor for nonpeptidergic nociceptor maturation. Elife 4:. PubMed: 26418744 MGI: J:226826
Hutcheson J; Perlman H. 2007. Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytes. Immunobiology 212(8):629-36. PubMed: 17869640 MGI: J:129934
Hutcheson J; Scatizzi JC; Bickel E; Brown NJ; Bouillet P; Strasser A; Perlman H. 2005. Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis. J Exp Med 201(12):1949-60. PubMed: 15967824 MGI: J:99285
Imao T; Nagata S. 2013. Apaf-1- and Caspase-8-independent apoptosis. Cell Death Differ 20(2):343-52. PubMed: 23197294 MGI: J:205616
Jabbour AM; Heraud JE; Daunt CP; Kaufmann T; Sandow J; O'Reilly LA; Callus BA; Lopez A; Strasser A; Vaux DL; Ekert PG. 2009. Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death Differ 16(4):555-63. PubMed: 19079139 MGI: J:158076
Jacob DA; Bengston CL; Forger NG. 2005. Effects of Bax gene deletion on muscle and motoneuron degeneration in a sexually dimorphic neuromuscular system. J Neurosci 25(23):5638-44. PubMed: 15944391 MGI: J:98923
Jacquin MF; Arends JJ; Xiang C; Shapiro LA; Ribak CE; Chen ZF. 2008. In DRG11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterning. J Neurosci 28(14):3577-85. PubMed: 18385316 MGI: J:133752
Jamerson MH; Johnson MD; Korsmeyer SJ; Furth PA; Dickson RB. 2004. Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice. Br J Cancer 91(7):1372-9. PubMed: 15354213 MGI: J:92916
Janssen K; Horn S; Niemann MT; Daniel PT; Schulze-Osthoff K; Fischer U. 2009. Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis. J Cell Sci 122(Pt 24):4481-91. PubMed: 19920074 MGI: J:155568
Jeffers JR; Parganas E; Lee Y; Yang C; Wang J; Brennan J; MacLean KH; Han J; Chittenden T; Ihle JN; McKinnon PJ; Cleveland JL; Zambetti GP. 2003. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4(4):321-8. PubMed: 14585359 MGI: J:115660
Jeong YH; Kim JM; Yoo J; Lee SH; Kim HS; Suh YH. 2011. Environmental enrichment compensates for the effects of stress on disease progression in Tg2576 mice, an Alzheimer's disease model. J Neurochem 119(6):1282-93. PubMed: 21967036 MGI: J:178457
Jones RG; Bui T; White C; Madesh M; Krawczyk CM; Lindsten T; Hawkins BJ; Kubek S; Frauwirth KA; Wang YL; Conway SJ; Roderick HL; Bootman MD; Shen H; Foskett JK; Thompson CB. 2007. The Proapoptotic Factors Bax and Bak Regulate T Cell Proliferation through Control of Endoplasmic Reticulum Ca(2+) Homeostasis. Immunity 27(2):268-80. PubMed: 17692540 MGI: J:124342
Josefsson EC; Burnett DL; Lebois M; Debrincat MA; White MJ; Henley KJ; Lane RM; Moujalled D; Preston SP; O'Reilly LA; Pellegrini M; Metcalf D; Strasser A; Kile BT. 2014. Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nat Commun 5:3455. PubMed: 24632563 MGI: J:210320
Josefsson EC; James C; Henley KJ; Debrincat MA; Rogers KL; Dowling MR; White MJ; Kruse EA; Lane RM; Ellis S; Nurden P; Mason KD; O'Reilly LA; Roberts AW; Metcalf D; Huang DC; Kile BT. 2011. Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med 208(10):2017-31. PubMed: 21911424 MGI: J:177288
Jung AR; Kim TW; Rhyu IJ; Kim H; Lee YD; Vinsant S; Oppenheim RW; Sun W. 2008. Misplacement of Purkinje cells during postnatal development in Bax knock-out mice: a novel role for programmed cell death in the nervous system? J Neurosci 28(11):2941-8. PubMed: 18337425 MGI: J:132984
Kang HR; Cho SJ; Lee CG; Homer RJ; Elias JA. 2007. Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. J Biol Chem 282(10):7723-32. PubMed: 17209037 MGI: J:120886
Karbowski M; Norris KL; Cleland MM; Jeong SY; Youle RJ. 2006. Role of Bax and Bak in mitochondrial morphogenesis. Nature 443(7112):658-62. PubMed: 17035996 MGI: J:113296
Kawai K; Itoh T; Itoh A; Horiuchi M; Wakayama K; Bannerman P; Garbern JY; Pleasure D; Lindsten T. 2009. Maintenance of the relative proportion of oligodendrocytes to axons even in the absence of BAX and BAK. Eur J Neurosci 30(11):2030-41. PubMed: 20128842 MGI: J:157612
Keeley PW; Madsen NR; St John AJ; Reese BE. 2014. Programmed cell death of retinal cone bipolar cells is independent of afferent or target control. Dev Biol 394(2):191-6. PubMed: 25169191 MGI: J:216143
Keeley PW; Zhou C; Lu L; Williams RW; Melmed S; Reese BE. 2014. Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics. Proc Natl Acad Sci U S A 111(25):9295-300. PubMed: 24927528 MGI: J:212096
Keramaris E; Ruzhynsky VA; Callaghan SM; Wong E; Davis RJ; Flavell R; Slack RS; Park DS. 2008. Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice. J Biol Chem 283(1):405-15. PubMed: 17984095 MGI: J:130256
Khaled AR; Li WQ; Huang J; Fry TJ; Khaled AS; Mackall CL; Muegge K; Young HA; Durum SK. 2002. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity 17(5):561-73. PubMed: 12433363 MGI: J:93139
Kim TW; Moon Y; Kim K; Lee JE; Koh HC; Rhyu IJ; Kim H; Sun W. 2011. Dissociation of progressive dopaminergic neuronal death and behavioral impairments by Bax deletion in a mouse model of Parkinson's diseases. PLoS One 6(10):e25346. PubMed: 22043283 MGI: J:179717
Kim WR; Chun SK; Kim TW; Kim H; Ono K; Takebayashi H; Ikenaka K; Oppenheim RW; Sun W. 2011. Evidence for the spontaneous production but massive programmed cell death of new neurons in the subcallosal zone of the postnatal mouse brain. Eur J Neurosci 33(4):599-611. PubMed: 21219476 MGI: J:174460
Kim WR; Kim Y; Eun B; Park OH; Kim H; Kim K; Park CH; Vinsant S; Oppenheim RW; Sun W. 2007. Impaired migration in the rostral migratory stream but spared olfactory function after the elimination of programmed cell death in Bax knock-out mice. J Neurosci 27(52):14392-403. PubMed: 18160647 MGI: J:130972
Kim WR; Park OH; Choi S; Choi SY; Park SK; Lee KJ; Rhyu IJ; Kim H; Lee YK; Kim HT; Oppenheim RW; Sun W. 2009. The maintenance of specific aspects of neuronal function and behavior is dependent on programmed cell death of adult-generated neurons in the dentate gyrus. Eur J Neurosci 29(7):1408-21. PubMed: 19519627 MGI: J:150199
Kim WR; Sun W. 2013. Enhanced odor discrimination learning in aged Bax-KO mice. Neurosci Lett 548:196-200. PubMed: 23685130 MGI: J:201550
Kinugasa T; Kudo N; Ozaki S. 2006. Peripheral targets influence sensory-motor connectivity in the neonatal spinal cord: sciatic nerve axotomy in Bax-deficient mice. Neurosci Res 54(1):30-7. PubMed: 16290239 MGI: J:105117
Kirkland RA; Saavedra GM; Cummings BS; Franklin JL. 2010. Bax regulates production of superoxide in both apoptotic and nonapoptotic neurons: role of caspases. J Neurosci 30(48):16114-27. PubMed: 21123558 MGI: J:166748
Kirsch DG; Dinulescu DM; Miller JB; Grimm J; Santiago PM; Young NP; Nielsen GP; Quade BJ; Chaber CJ; Schultz CP; Takeuchi O; Bronson RT; Crowley D; Korsmeyer SJ; Yoon SS; Hornicek FJ; Weissleder R; Jacks T. 2007. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med 13(8):992-7. PubMed: 17676052 MGI: J:125101
Kirsch DG; Santiago PM; di Tomaso E; Sullivan JM; Hou WS; Dayton T; Jeffords LB; Sodha P; Mercer KL; Cohen R; Takeuchi O; Korsmeyer SJ; Bronson RT; Kim CF; Haigis KM; Jain RK; Jacks T. 2010. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science 327(5965):593-6. PubMed: 20019247 MGI: J:156707
Knudson CM; Johnson GM; Lin Y; Korsmeyer SJ. 2001. Bax accelerates tumorigenesis in p53-deficient mice. Cancer Res 61(2):659-65. PubMed: 11212265 MGI: J:67325
Knudson CM; Korsmeyer SJ. 1997. Bcl-2 and Bax function independently to regulate cell death. Nat Genet 16(4):358-63. PubMed: 9241272 MGI: J:42051
Kodama T; Takehara T; Hikita H; Shimizu S; Shigekawa M; Li W; Miyagi T; Hosui A; Tatsumi T; Ishida H; Kanto T; Hiramatsu N; Yin XM; Hayashi N. 2011. BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency: MOLECULAR REQUISITES FOR THE MITOCHONDRIAL PATHWAY TO APOPTOSIS IN PLATELETS. J Biol Chem 286(16):13905-13. PubMed: 21367852 MGI: J:171123
Korhonen L; Hansson I; Maugras C; Wehrle R; Kairisalo M; Borgkvist A; Jokitalo E; Sotelo C; Fisone G; Dusart I; Lindholm D. 2008. Expression of X-chromosome linked inhibitor of apoptosis protein in mature Purkinje cells and in retinal bipolar cells in transgenic mice induces neurodegeneration. Neuroscience 156(3):515-26. PubMed: 18765270 MGI: J:141181
Koubova J; Hu YC; Bhattacharyya T; Soh YQ; Gill ME; Goodheart ML; Hogarth CA; Griswold MD; Page DC. 2014. Retinoic acid activates two pathways required for meiosis in mice. PLoS Genet 10(8):e1004541. PubMed: 25102060 MGI: J:215225
Krahe TE; Medina AE; Lantz CL; Filgueiras CC. 2015. Hyperactivity and depression-like traits in Bax KO mice. Brain Res 1625:246-54. PubMed: 26363094 MGI: J:229099
Kujjo LL; Laine T; Pereira RJ; Kagawa W; Kurumizaka H; Yokoyama S; Perez GI. 2010. Enhancing survival of mouse oocytes following chemotherapy or aging by targeting Bax and Rad51. PLoS One 5(2):e9204. PubMed: 20169201 MGI: J:157991
Kuruvilla R; Zweifel LS; Glebova NO; Lonze BE; Valdez G; Ye H; Ginty DD. 2004. A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell 118(2):243-55. PubMed: 15260993 MGI: J:91949
Laird DJ; Altshuler-Keylin S; Kissner MD; Zhou X; Anderson KV. 2011. Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet 7(12):e1002428. PubMed: 22216013 MGI: J:179805
Lallemend F; Sterzenbach U; Hadjab-Lallemend S; Aquino JB; Castelo-Branco G; Sinha I; Villaescusa JC; Levanon D; Wang Y; Franck MC; Kharchenko O; Adameyko I; Linnarsson S; Groner Y; Turner E; Ernfors P. 2012. Positional differences of axon growth rates between sensory neurons encoded by Runx3. EMBO J 31(18):3718-29. PubMed: 22903063 MGI: J:189922
Lassot I; Robbins I; Kristiansen M; Rahmeh R; Jaudon F; Magiera MM; Mora S; Vanhille L; Lipkin A; Pettmann B; Ham J; Desagher S. 2010. Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis. Cell Death Differ 17(12):1928-41. PubMed: 20559321 MGI: J:186344
Lechner SG; Frenzel H; Wang R; Lewin GR. 2009. Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. EMBO J 28(10):1479-91. PubMed: 19322198 MGI: J:148796
Lee J; Friese A; Mielich M; Sigrist M; Arber S. 2012. Scaling proprioceptor gene transcription by retrograde NT3 signaling. PLoS One 7(9):e45551. PubMed: 23029089 MGI: J:191993
Lee JW; Kim WR; Sun W; Jung MW. 2012. Disruption of Dentate Gyrus Blocks Effect of Visual Input on Spatial Firing of CA1 Neurons. J Neurosci 32(38):12999-3003. PubMed: 22993417 MGI: J:188107
Lee JW; Kim WR; Sun W; Jung MW. 2009. Role of dentate gyrus in aligning internal spatial map to external landmark. Learn Mem 16(9):530-6. PubMed: 19706836 MGI: J:164948
Lee SC; Cowgill EJ; Al-Nabulsi A; Quinn EJ; Evans SM; Reese BE. 2011. Homotypic regulation of neuronal morphology and connectivity in the mouse retina. J Neurosci 31(40):14126-33. PubMed: 21976497 MGI: J:177107
Lefebvre JL; Kostadinov D; Chen WV; Maniatis T; Sanes JR. 2012. Protocadherins mediate dendritic self-avoidance in the mammalian nervous system. Nature 488(7412):517-21. PubMed: 22842903 MGI: J:186772
Lefebvre JL; Zhang Y; Meister M; Wang X; Sanes JR. 2008. {gamma}-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina. Development 135(24):4141-51. PubMed: 19029044 MGI: J:142186
Lei L; Laub F; Lush M; Romero M; Zhou J; Luikart B; Klesse L; Ramirez F; Parada LF. 2005. The zinc finger transcription factor Klf7 is required for TrkA gene expression and development of nociceptive sensory neurons. Genes Dev 19(11):1354-64. PubMed: 15937222 MGI: J:98715
Lewis J; Oyler GA; Ueno K; Fannjiang YR; Chau BN; Vornov J; Korsmeyer SJ; Zou S; Hardwick JM. 1999. Inhibition of virus-induced neuronal apoptosis by Bax. Nat Med 5(7):832-5. PubMed: 10395331 MGI: J:124238
Li S; Sukeena JM; Simmons AB; Hansen EJ; Nuhn RE; Samuels IS; Fuerst PG. 2015. DSCAM Promotes Refinement in the Mouse Retina through Cell Death and Restriction of Exploring Dendrites. J Neurosci 35(14):5640-54. PubMed: 25855178 MGI: J:219627
Libby RT; Li Y; Savinova OV; Barter J; Smith RS; Nickells RW; John SW. 2005. Susceptibility to neurodegeneration in a glaucoma is modified by bax gene dosage. PLoS Genet 1(1):e4. PubMed: 16103918 MGI: J:100118
Lilley BN; Pan YA; Sanes JR. 2013. SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals. Neuron 79(1):39-53. PubMed: 23790753 MGI: J:201695
Lin L; Lee VM; Wang Y; Lin JS; Sock E; Wegner M; Lei L. 2011. Sox11 regulates survival and axonal growth of embryonic sensory neurons. Dev Dyn 240(1):52-64. PubMed: 21117150 MGI: J:166964
Lin MH; Leimeister C; Gessler M; Kopan R. 2000. Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers. Development 127(11):2421-32. PubMed: 10804183 MGI: J:62217
Lindenboim L; Kringel S; Braun T; Borner C; Stein R. 2005. Bak but not Bax is essential for Bcl-xS-induced apoptosis. Cell Death Differ 12(7):713-23. PubMed: 15861188 MGI: J:111864
Lindsten T; Golden JA; Zong WX; Minarcik J; Harris MH; Thompson CB. 2003. The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool. J Neurosci 23(35):11112-9. PubMed: 14657169 MGI: J:87971
Lindsten T; Ross AJ; King A; Zong WX; Rathmell JC; Shiels HA; Ulrich E; Waymire KG; Mahar P; Frauwirth K; Chen Y; Wei M; Eng VM; Adelman DM; Simon MC; Ma A; Golden JA; Evan G; Korsmeyer SJ; MacGregor GR; Thompson CB. 2000. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6(6):1389-99. PubMed: 11163212 MGI: J:66872
Lindsten T; Thompson CB. 2006. Cell death in the absence of Bax and Bak. Cell Death Differ 13(8):1272-6. PubMed: 16676001 MGI: J:126409
Liu J; Naegele JR; Lin SL. 2009. The DNA-PK catalytic subunit regulates Bax-mediated excitotoxic cell death by Ku70 phosphorylation. Brain Res 1296:164-75. PubMed: 19664609 MGI: J:157421
Liu Y; Rutlin M; Huang S; Barrick CA; Wang F; Jones KR; Tessarollo L; Ginty DD. 2012. Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland. Science 338(6112):1357-60. PubMed: 23224557 MGI: J:192549
Lonze BE; Riccio A; Cohen S; Ginty DD. 2002. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron 34(3):371-85. PubMed: 11988169 MGI: J:76363
Lu MY; Liao F. 2011. Interferon-stimulated gene ISG12b2 is localized to the inner mitochondrial membrane and mediates virus-induced cell death. Cell Death Differ 18(6):925-36. PubMed: 21151029 MGI: J:186970
Lu X; Yang C; Yin C; Van Dyke T; Simin K. 2011. Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression. Mol Cancer Res 9(4):430-9. PubMed: 21385880 MGI: J:205228
Lu YP; Lou YR; Peng QY; Xie JG; Conney AH. 2004. Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice. Cancer Res 64(14):5020-7. PubMed: 15256477 MGI: J:91506
Luciani DS; White SA; Widenmaier SB; Saran VV; Taghizadeh F; Hu X; Allard MF; Johnson JD. 2013. Bcl-2 and Bcl-xL suppress glucose signaling in pancreatic beta-cells. Diabetes 62(1):170-82. PubMed: 22933114 MGI: J:208489
Luedke AC; Boucher PO; Niel L; Holmes MM. 2013. Altered anxiety and defensive behaviors in Bax knockout mice. Behav Brain Res 239:115-20. PubMed: 23142367 MGI: J:197074
Lum JJ; Bauer DE; Kong M; Harris MH; Li C; Lindsten T; Thompson CB. 2005. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120(2):237-48. PubMed: 15680329 MGI: J:97305
Luo W; Wickramasinghe SR; Savitt JM; Griffin JW; Dawson TM; Ginty DD. 2007. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron 54(5):739-54. PubMed: 17553423 MGI: J:126484
Ma CH; Omura T; Cobos EJ; Latremoliere A; Ghasemlou N; Brenner GJ; van Veen E; Barrett L; Sawada T; Gao F; Coppola G; Gertler F; Costigan M; Geschwind D; Woolf CJ. 2011. Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. J Clin Invest 121(11):4332-47. PubMed: 21965333 MGI: J:178458
Ma L; Lei L; Eng SR; Turner E; Parada LF. 2003. Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Development 130(15):3525-34. PubMed: 12810599 MGI: J:83805
Maatouk DM; Mork L; Chassot AA; Chaboissier MC; Capel B. 2013. Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary. Dev Biol 383(2):295-306. PubMed: 24036309 MGI: J:203797
Mandai K; Guo T; St Hillaire C; Meabon JS; Kanning KC; Bothwell M; Ginty DD. 2009. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron 63(5):614-27. PubMed: 19755105 MGI: J:154926
Mann-Chandler MN; Kashyap M; Wright HV; Norozian F; Barnstein BO; Gingras S; Parganas E; Ryan JJ. 2005. IFN-gamma induces apoptosis in developing mast cells. J Immunol 175(5):3000-5. PubMed: 16116187 MGI: J:113205
Martin LJ; Kaiser A; Yu JW; Natale JE; Al-Abdulla NA. 2001. Injury-induced apoptosis of neurons in adult brain is mediated by p53-dependent and p53-independent pathways and requires Bax. J Comp Neurol 433(3):299-311. PubMed: 11298357 MGI: J:121197
Mason KD; Carpinelli MR; Fletcher JI; Collinge JE; Hilton AA; Ellis S; Kelly PN; Ekert PG; Metcalf D; Roberts AW; Huang DC; Kile BT. 2007. Programmed anuclear cell death delimits platelet life span. Cell 128(6):1173-86. PubMed: 17382885 MGI: J:149205
Mason KD; Lin A; Robb L; Josefsson EC; Henley KJ; Gray DH; Kile BT; Roberts AW; Strasser A; Huang DC; Waring P; O'Reilly LA. 2013. Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease. Proc Natl Acad Sci U S A 110(7):2599-604. PubMed: 23349374 MGI: J:194331
McKenzie MD; Carrington EM; Kaufmann T; Strasser A; Huang DC; Kay TW; Allison J; Thomas HE. 2008. Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells. Diabetes 57(5):1284-92. PubMed: 18252892 MGI: J:135326
McKenzie MD; Jamieson E; Jansen ES; Scott CL; Huang DC; Bouillet P; Allison J; Kay TW; Strasser A; Thomas HE. 2010. Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes 59(3):644-52. PubMed: 19959756 MGI: J:164154
Mebratu YA; Dickey BF; Evans C; Tesfaigzi Y. 2008. The BH3-only protein Bik/Blk/Nbk inhibits nuclear translocation of activated ERK1/2 to mediate IFNgamma-induced cell death. J Cell Biol 183(3):429-39. PubMed: 18981230 MGI: J:141068
Merino D; Khaw SL; Glaser SP; Anderson DJ; Belmont LD; Wong C; Yue P; Robati M; Phipson B; Fairlie WD; Lee EF; Campbell KJ; Vandenberg CJ; Cory S; Roberts AW; Ludlam MJ; Huang DC; Bouillet P. 2012. Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood 119(24):5807-16. PubMed: 22538851 MGI: J:188645
Metrailler S; Schorderet DF; Cottet S. 2012. Early apoptosis of rod photoreceptors in Rpe65(-/-) mice is associated with the upregulated expression of lysosomal-mediated autophagic genes. Exp Eye Res 96(1):70-81. PubMed: 22227450 MGI: J:196780
Middleton G; Cox SW; Korsmeyer S; Davies AM. 2000. Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations. Eur J Neurosci 12(3):819-27. PubMed: 10762311 MGI: J:63350
Middleton G; Davies AM. 2001. Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo. Development 128(23):4715-28. PubMed: 11731452 MGI: J:72722
Misgeld T; Burgess RW; Lewis RM; Cunningham JM; Lichtman JW; Sanes JR. 2002. Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase. Neuron 36(4):635-48. PubMed: 12441053 MGI: J:91066
Mo J; Marshall B; Covar J; Zhang NY; Smith SB; Atherton SS; Zhang M. 2014. Role of Bax in death of uninfected retinal cells during murine cytomegalovirus retinitis. Invest Ophthalmol Vis Sci 55(11):7137-46. PubMed: 25298417 MGI: J:230322
Moqrich A; Earley TJ; Watson J; Andahazy M; Backus C; Martin-Zanca D; Wright DE; Reichardt LF; Patapoutian A. 2004. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci 7(8):812-8. PubMed: 15247919 MGI: J:92099
Morita Y; Maravei DV; Bergeron L; Wang S; Perez GI; Tsutsumi O; Taketani Y; Asano M; Horai R; Korsmeyer SJ; Iwakura Y; Yuan J; Tilly JL. 2001. Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function. Cell Death Differ 8(6):614-20. PubMed: 11536012 MGI: J:115619
Mosinger Ogilvie J; Deckwerth TL; Knudson CM; Korsmeyer SJ. 1998. Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice [published erratum appears in Invest Ophthalmol Vis Sci 1998 Nov;39(12):2244] Invest Ophthalmol Vis Sci 39(9):1713-20. PubMed: 9699561 MGI: J:49526
Mosley M; Shah C; Morse KA; Miloro SA; Holmes MM; Ahern TH; Forger NG. 2017. Patterns of cell death in the perinatal mouse forebrain. J Comp Neurol 525(1):47-64. PubMed: 27199256 MGI: J:238438
Moubarak RS; Yuste VJ; Artus C; Bouharrour A; Greer PA; Menissier-de Murcia J; Susin SA. 2007. Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol 27(13):4844-62. PubMed: 17470554 MGI: J:122803
Myers CE; Bermudez-Hernandez K; Scharfman HE. 2013. The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function. PLoS One 8(6):e68208. PubMed: 23840835 MGI: J:204319
Nakamura S; Senzaki K; Yoshikawa M; Nishimura M; Inoue K; Ito Y; Ozaki S; Shiga T. 2008. Dynamic regulation of the expression of neurotrophin receptors by Runx3. Development 135(9):1703-11. PubMed: 18385258 MGI: J:134495
Nedvetsky PI; Emmerson E; Finley JK; Ettinger A; Cruz-Pacheco N; Prochazka J; Haddox CL; Northrup E; Hodges C; Mostov KE; Hoffman MP; Knox SM. 2014. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell 30(4):449-62. PubMed: 25158854 MGI: J:232152
Nikolaev A ; McLaughlin T ; O'Leary DD ; Tessier-Lavigne M. 2009. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457(7232):981-9. PubMed: 19225519 MGI: J:146602
Nogueira CV; Lindsten T; Jamieson AM; Case CL; Shin S; Thompson CB; Roy CR. 2009. Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila. PLoS Pathog 5(6):e1000478. PubMed: 19521510 MGI: J:211458
O'Donovan KJ; Ma K; Guo H; Wang C; Sun F; Han SB; Kim H; Wong JK; Charron J; Zou H; Son YJ; He Z; Zhong J. 2014. B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med 211(5):801-14. PubMed: 24733831 MGI: J:213126
Okamoto T; Coultas L; Metcalf D; van Delft MF; Glaser SP; Takiguchi M; Strasser A; Bouillet P; Adams JM; Huang DC. 2014. Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis. Proc Natl Acad Sci U S A 111(1):261-6. PubMed: 24363325 MGI: J:206385
Owens TW; Foster FM; Valentijn A; Gilmore AP; Streuli CH. 2010. Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization. J Biol Chem 285(2):1081-8. PubMed: 19875445 MGI: J:161686
Ozdinler PH; Macklis JD. 2006. IGF-I specifically enhances axon outgrowth of corticospinal motor neurons. Nat Neurosci 9(11):1371-81. PubMed: 17057708 MGI: J:114984
Pardo J; Urban C; Galvez EM; Ekert PG; Muller U; Kwon-Chung J; Lobigs M; Mullbacher A; Wallich R; Borner C; Simon MM. 2006. The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. J Cell Biol 174(4):509-19. PubMed: 16893972 MGI: J:112620
Park OH; Lee KJ; Rhyu IJ; Geum D; Kim H; Buss R; Oppenheim RW; Sun W. 2007. Bax-dependent and -independent death of motoneurons after facial nerve injury in adult mice. Eur J Neurosci 26(6):1421-32. PubMed: 17822434 MGI: J:127254
Patel AV; Krimm RF. 2010. BDNF is required for the survival of differentiated geniculate ganglion neurons. Dev Biol 340(2):419-29. PubMed: 20122917 MGI: J:160265
Patel TD; Jackman A; Rice FL; Kucera J; Snider WD. 2000. Development of sensory neurons in the absence of NGF/TrkA signaling in vivo [see comments] Neuron 25(2):345-57. PubMed: 10719890 MGI: J:60772
Patel TD; Kramer I; Kucera J; Niederkofler V; Jessell TM; Arber S; Snider WD. 2003. Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents. Neuron 38(3):403-16. PubMed: 12741988 MGI: J:83461
Pei L; Shang Y; Jin H; Wang S; Wei N; Yan H; Wu Y; Yao C; Wang X; Zhu LQ; Lu Y. 2014. DAPK1-p53 interaction converges necrotic and apoptotic pathways of ischemic neuronal death. J Neurosci 34(19):6546-56. PubMed: 24806680 MGI: J:211044
Pelzel HR; Schlamp CL; Waclawski M; Shaw MK; Nickells RW. 2012. Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity. Invest Ophthalmol Vis Sci 53(3):1428-35. PubMed: 22297488 MGI: J:196753
Pequignot MO; Provost AC; Salle S; Taupin P; Sainton KM; Marchant D; Martinou JC; Ameisen JC; Jais JP; Abitbol M. 2003. Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina. Dev Dyn 228(2):231-8. PubMed: 14517994 MGI: J:85918
Perez GI; Jurisicova A; Wise L; Lipina T; Kanisek M; Bechard A; Takai Y; Hunt P; Roder J; Grynpas M; Tilly JL. 2007. Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice. Proc Natl Acad Sci U S A 104(12):5229-34. PubMed: 17360389 MGI: J:120089
Perez GI; Robles R; Knudson CM; Flaws JA; Korsmeyer SJ; Tilly JL. 1999. Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. Nat Genet 21(2):200-3. PubMed: 9988273 MGI: J:52574
Pestina TI; Cleveland JL; Yang C; Zambetti GP; Jackson CW. 2001. Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis. Blood 98(7):2084-90. PubMed: 11567994 MGI: J:115633
Prasad T; Wang X; Gray PA; Weiner JA. 2008. A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-{gamma} gene cluster. Development 135(24):4153-64. PubMed: 19029045 MGI: J:142349
Prasad T; Weiner JA. 2011. Direct and Indirect Regulation of Spinal Cord Ia Afferent Terminal Formation by the gamma-Protocadherins. Front Mol Neurosci 4:54. PubMed: 22275881 MGI: J:190261
Pritchard DM; Potten CS; Korsmeyer SJ; Roberts S; Hickman JA. 1999. Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. Oncogene 18(51):7287-93. PubMed: 10602483 MGI: J:59016
Przemeck SM; Duckworth CA; Pritchard DM. 2007. Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. Am J Physiol Gastrointest Liver Physiol 292(2):G620-7. PubMed: 17068116 MGI: J:124814
Qi Q; Huang W; Bai Y; Balmus G; Weiss RS; August A. 2012. A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice. J Immunol 188(8):3611-9. PubMed: 22403441 MGI: J:184083
Qiu W; Carson-Walter EB; Liu H; Epperly M; Greenberger JS; Zambetti GP; Zhang L; Yu J. 2008. PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell 2(6):576-83. PubMed: 18522850 MGI: J:149798
Quach DH; Oliveira-Fernandes M; Gruner KA; Tourtellotte WG. 2013. A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. J Neurosci 33(10):4570-83. PubMed: 23467373 MGI: J:196371
Rabionet M; van der Spoel AC; Chuang CC; von Tumpling-Radosta B; Litjens M; Bouwmeester D; Hellbusch CC; Korner C; Wiegandt H; Gorgas K; Platt FM; Grone HJ; Sandhoff R. 2008. Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. J Biol Chem 283(19):13357-69. PubMed: 18308723 MGI: J:137091
Rakowicz WP; Staples CS; Milbrandt J; Brunstrom JE; Johnson EM Jr. 2002. Glial cell line-derived neurotrophic factor promotes the survival of early postnatal spinal motor neurons in the lateral and medial motor columns in slice culture. J Neurosci 22(10):3953-62. PubMed: 12019314 MGI: J:126984
Robinson AM; Conley DB; Kern RC. 2003. Olfactory neurons in bax knockout mice are protected from bulbectomy-induced apoptosis. Neuroreport 14(15):1891-4. PubMed: 14561915 MGI: J:89724
Rong Y; Wei P; Parris J; Guo H; Pattarini R; Correia K; Li L; Kusnoor SV; Deutch AY; Morgan JI. 2012. Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice. J Neurochem 120(4):528-40. PubMed: 22117778 MGI: J:182277
Ross AJ; Amy SP; Mahar PL; Lindsten T; Knudson CM; Thompson CB; Korsmeyer SJ; MacGregor GR. 2001. BCLW Mediates Survival of Postmitotic Sertoli Cells by Regulating BAX Activity. Dev Biol 239(2):295-308. PubMed: 11784036 MGI: J:72582
Rucker EB 3rd; Dierisseau P; Wagner KU; Garrett L; Wynshaw-Boris A; Flaws JA; Hennighausen L. 2000. Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis Mol Endocrinol 14(7):1038-52. PubMed: 10894153 MGI: J:63161
Ruiz-Vela A; Opferman JT; Cheng EH; Korsmeyer SJ. 2005. Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep 6(4):379-85. PubMed: 15776018 MGI: J:97306
Rundle CH; Wang X; Sheng MH; Wergedal JE; Lau KH; Mohan S. 2008. Bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis. Bone 43(5):880-8. PubMed: 18708175 MGI: J:142303
Runyan C; Gu Y; Shoemaker A; Looijenga L; Wylie C. 2008. The distribution and behavior of extragonadal primordial germ cells in Bax mutant mice suggest a novel origin for sacrococcygeal germ cell tumors. Int J Dev Biol 52(4):333-44. PubMed: 18415933 MGI: J:133945
Runyan C; Schaible K; Molyneaux K; Wang Z; Levin L; Wylie C. 2006. Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration. Development 133(24):4861-9. PubMed: 17107997 MGI: J:115283
Russell LD; Chiarini-Garcia H; Korsmeyer SJ; Knudson CM. 2002. Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis. Biol Reprod 66(4):950-8. PubMed: 11906913 MGI: J:75666
Sanchez-Gomez MV; Alberdi E; Perez-Navarro E; Alberch J; Matute C. 2011. Bax and calpain mediate excitotoxic oligodendrocyte death induced by activation of both AMPA and kainate receptors. J Neurosci 31(8):2996-3006. PubMed: 21414921 MGI: J:180921
Sandow JJ; Dorstyn L; O'Reilly LA; Tailler M; Kumar S; Strasser A; Ekert PG. 2014. ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis. Cell Death Differ 21(3):475-80. PubMed: 24292555 MGI: J:229151
Sarosiek KA; Fraser C; Muthalagu N; Bhola PD; Chang W; McBrayer SK; Cantlon A; Fisch S; Golomb-Mello G; Ryan JA; Deng J; Jian B; Corbett C; Goldenberg M; Madsen JR; Liao R; Walsh D; Sedivy J; Murphy DJ; Carrasco DR; Robinson S; Moslehi J; Letai A. 2017. Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics. Cancer Cell 31(1):142-156. PubMed: 28017613 MGI: J:238415
Schoenmann Z; Assa-Kunik E; Tiomny S; Minis A; Haklai-Topper L; Arama E; Yaron A. 2010. Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals. J Neurosci 30(18):6375-86. PubMed: 20445064 MGI: J:160556
Schoenwaelder SM; Yuan Y; Josefsson EC; White MJ; Yao Y; Mason KD; O'Reilly LA; Henley KJ; Ono A; Hsiao S; Willcox A; Roberts AW; Huang DC; Salem HH; Kile BT; Jackson SP. 2009. Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood 114(3):663-6. PubMed: 19387006 MGI: J:150769
Schweers RL; Zhang J; Randall MS; Loyd MR; Li W; Dorsey FC; Kundu M; Opferman JT; Cleveland JL; Miller JL; Ney PA. 2007. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A 104(49):19500-5. PubMed: 18048346 MGI: J:141545
Selimi F; Vogel MW; Mariani J. 2000. Bax inactivation in lurcher mutants rescues cerebellar granule cells but not purkinje cells or inferior olivary neurons. J Neurosci 20(14):5339-45. PubMed: 10884318 MGI: J:63483
Senzaki K; Ozaki S; Yoshikawa M; Ito Y; Shiga T. 2010. Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons. Mol Cell Neurosci 43(3):296-307. PubMed: 20034568 MGI: J:158404
Shacka JJ; Klocke BJ; Young C; Shibata M; Olney JW; Uchiyama Y; Saftig P; Roth KA. 2007. Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. J Neurosci 27(8):2081-90. PubMed: 17314303 MGI: J:141738
Shi J; Miles DK; Orr BA; Massa SM; Kernie SG. 2007. Injury-induced neurogenesis in Bax-deficient mice: evidence for regulation by voltage-gated potassium channels. Eur J Neurosci 25(12):3499-512. PubMed: 17610570 MGI: J:126093
Shi J; Parada LF; Kernie SG. 2005. Bax limits adult neural stem cell persistance through caspase and IP3 receptor activation Cell Death Differ 12(12):1601-1612. PubMed: 15947791 MGI: J:116534
Shibata MA; Liu ML; Knudson MC; Shibata E; Yoshidome K; Bandey T ; Korsmeyer SJ ; Green JE. 1999. Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage. EMBO J 18(10):2692-701. PubMed: 10329616 MGI: J:55778
Shibue T; Takeda K; Oda E; Tanaka H; Murasawa H; Takaoka A; Morishita Y; Akira S; Taniguchi T; Tanaka N. 2003. Integral role of Noxa in p53-mediated apoptotic response. Genes Dev 17(18):2233-8. PubMed: 12952892 MGI: J:85569
Simon DJ; Weimer RM; McLaughlin T; Kallop D; Stanger K; Yang J; O'Leary DD; Hannoush RN; Tessier-Lavigne M. 2012. A caspase cascade regulating developmental axon degeneration. J Neurosci 32(49):17540-53. PubMed: 23223278 MGI: J:193196
Smith MI; Deshmukh M. 2007. Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons. Cell Death Differ 14(5):1011-9. PubMed: 17218955 MGI: J:139276
Someya S; Xu J; Kondo K; Ding D; Salvi RJ; Yamasoba T; Rabinovitch PS; Weindruch R; Leeuwenburgh C; Tanokura M; Prolla TA. 2009. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci U S A 106(46):19432-7. PubMed: 19901338 MGI: J:154747
Southwell DG; Paredes MF; Galvao RP; Jones DL; Froemke RC; Sebe JY; Alfaro-Cervello C; Tang Y; Garcia-Verdugo JM; Rubenstein JL; Baraban SC; Alvarez-Buylla A. 2012. Intrinsically determined cell death of developing cortical interneurons. Nature 491(7422):109-13. PubMed: 23041929 MGI: J:189225
Speiran K; Bailey DP; Fernando J; Macey M; Barnstein B; Kolawole M; Curley D; Watowich SS; Murray PJ; Oskeritzian C; Ryan JJ. 2009. Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol 85(5):826-36. PubMed: 19228815 MGI: J:149777
Stallock J; Molyneaux K; Schaible K; Knudson CM; Wylie C. 2003. The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo. Development 130(26):6589-97. PubMed: 14660547 MGI: J:86513
Steckley D; Karajgikar M; Dale LB; Fuerth B; Swan P; Drummond-Main C; Poulter MO; Ferguson SS; Strasser A; Cregan SP. 2007. Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci 27(47):12989-99. PubMed: 18032672 MGI: J:127640
Steele AD; King OD; Jackson WS; Hetz CA; Borkowski AW; Thielen P; Wollmann R; Lindquist S. 2007. Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. J Neurosci 27(47):13022-7. PubMed: 18032675 MGI: J:141553
Steimer DA; Boyd K; Takeuchi O; Fisher JK; Zambetti GP; Opferman JT. 2009. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood 113(12):2805-15. PubMed: 19064728 MGI: J:146310
Su H; Marcheva B; Meng S; Liang FA; Kohsaka A; Kobayashi Y; Xu AW; Bass J; Wang X. 2010. Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice. Dev Biol 339(1):38-50. PubMed: 20025866 MGI: J:157958
Sun W; Gould TW; Vinsant S; Prevette D; Oppenheim RW. 2003. Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion. J Neurosci 23(19):7298-310. PubMed: 12917363 MGI: J:88191
Sun W; Oppenheim RW. 2003. Response of motoneurons to neonatal sciatic nerve axotomy in Bax-knockout mice. Mol Cell Neurosci 24(4):875-86. PubMed: 14697655 MGI: J:87200
Sun W; Winseck A; Vinsant S; Park OH; Kim H; Oppenheim RW. 2004. Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax. J Neurosci 24(49):11205-13. PubMed: 15590937 MGI: J:96804
Suo D; Park J; Harrington AW; Zweifel LS; Mihalas S; Deppmann CD. 2014. Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat Neurosci 17(1):36-45. PubMed: 24270184 MGI: J:207835
Suzuki A; Igarashi K; Aisaki K; Kanno J; Saga Y. 2010. NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs. Proc Natl Acad Sci U S A 107(8):3594-9. PubMed: 20133598 MGI: J:157579
Suzuki A; Saga Y. 2008. Nanos2 suppresses meiosis and promotes male germ cell differentiation. Genes Dev 22(4):430-5. PubMed: 18281459 MGI: J:132711
Suzuki H; Aoyama Y; Senzaki K; Vincler M; Wittenauer S; Yoshikawa M; Ozaki S; Oppenheim RW; Shiga T. 2010. Characterization of sensory neurons in the dorsal root ganglia of Bax-deficient mice. Brain Res 1362:23-31. PubMed: 20846512 MGI: J:166957
Suzuki H; Tsuda M; Kiso M; Saga Y. 2008. Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev Biol 318(1):133-42. PubMed: 18436203 MGI: J:136687
Takeuchi O; Fisher J; Suh H; Harada H; Malynn BA; Korsmeyer SJ. 2005. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A 102(32):11272-7. PubMed: 16055554 MGI: J:100463
Tanaka T; Wakabayashi T; Oizumi H; Nishio S; Sato T; Harada A; Fujii D; Matsuo Y; Hashimoto T; Iwatsubo T. 2014. CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. J Neurosci 34(4):1370-9. PubMed: 24453327 MGI: J:206855
Tesfaigzi Y; Fischer MJ; Daheshia M; Green FH; De Sanctis GT; Wilder JA. 2002. Bax is crucial for IFN-gamma-induced resolution of allergen-induced mucus cell metaplasia. J Immunol 169(10):5919-25. PubMed: 12421976 MGI: J:80074
Tessner TG; Muhale F; Riehl TE; Anant S; Stenson WF. 2004. Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J Clin Invest 114(11):1676-85. PubMed: 15578100 MGI: J:94433
Tian H; Ma M. 2008. Activity plays a role in eliminating olfactory sensory neurons expressing multiple odorant receptors in the mouse septal organ. Mol Cell Neurosci 38(4):484-8. PubMed: 18538580 MGI: J:141795
Uesaka T; Enomoto H. 2010. Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice. J Neurosci 30(15):5211-8. PubMed: 20392943 MGI: J:159854
Uesaka T; Jain S; Yonemura S; Uchiyama Y; Milbrandt J; Enomoto H. 2007. Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development 134(11):2171-81. PubMed: 17507417 MGI: J:122607
Uo T; Kinoshita Y; Morrison RS. 2007. Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons. J Neurosci 27(45):12198-210. PubMed: 17989286 MGI: J:127443
Upton JP; Austgen K; Nishino M; Coakley KM; Hagen A; Han D; Papa FR; Oakes SA. 2008. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol 28(12):3943-51. PubMed: 18426910 MGI: J:137299
Vandenberg CJ; Josefsson EC; Campbell KJ; James C; Lawlor KE; Kile BT; Cory S. 2014. Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice. Cell Death Differ 21(5):676-84. PubMed: 24464220 MGI: J:229362
Vaughn AE; Deshmukh M. 2007. Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons. Cell Death Differ 14(5):973-81. PubMed: 17218959 MGI: J:139242
Vila M; Jackson-Lewis V; Vukosavic S; Djaldetti R; Liberatore G; Offen D; Korsmeyer SJ; Przedborski S. 2001. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 98(5):2837-42. PubMed: 11226327 MGI: J:67861
Villunger A; Scott C; Bouillet P; Strasser A. 2003. Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival. Blood 101(6):2393-400. PubMed: 12433687 MGI: J:82641
Vince JE; Wong WW; Gentle I; Lawlor KE; Allam R; O'Reilly L; Mason K; Gross O; Ma S; Guarda G; Anderton H; Castillo R; Hacker G; Silke J; Tschopp J. 2012. Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation. Immunity 36(2):215-27. PubMed: 22365665 MGI: J:181625
Wang X; Eno CO; Altman BJ; Zhu Y; Zhao G; Olberding KE; Rathmell JC; Li C. 2011. ER stress modulates cellular metabolism. Biochem J 435(1):285-96. PubMed: 21241252 MGI: J:170628
Weiner JA; Wang X; Tapia JC; Sanes JR. 2005. Gamma protocadherins are required for synaptic development in the spinal cord. Proc Natl Acad Sci U S A 102(1):8-14. PubMed: 15574493 MGI: J:95826
Weinlich R; Oberst A; Dillon CP; Janke LJ; Milasta S; Lukens JR; Rodriguez DA; Gurung P; Savage C; Kanneganti TD; Green DR. 2013. Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Rep 5(2):340-8. PubMed: 24095739 MGI: J:203778
Werth JL; Deshmukh M; Cocabo J; Johnson EM Jr; Rothman SM. 2000. Reversible physiological alterations in sympathetic neurons deprived of NGF but protected from apoptosis by caspase inhibition or Bax deletion. Exp Neurol 161(1):203-11. PubMed: 10683286 MGI: J:115320
White FA; Keller-Peck CR; Knudson CM; Korsmeyer SJ; Snider WD. 1998. Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. J Neurosci 18(4):1428-39. PubMed: 9454852 MGI: J:45764
White MJ; Schoenwaelder SM; Josefsson EC; Jarman KE; Henley KJ; James C; Debrincat MA; Jackson SP; Huang DC; Kile BT. 2012. Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood 119(18):4283-90. PubMed: 22294729 MGI: J:185011
Whitney IE; Raven MA; Ciobanu DC; Williams RW; Reese BE. 2009. Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina. Invest Ophthalmol Vis Sci 50(5):1996-2003. PubMed: 19168892 MGI: J:149703
Wickramasinghe SR; Alvania RS; Ramanan N; Wood JN; Mandai K; Ginty DD. 2008. Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron 58(4):532-45. PubMed: 18498735 MGI: J:145293
Winseck AK; Oppenheim RW. 2006. An in vivo analysis of Schwann cell programmed cell death in embryonic mice: the role of axons, glial growth factor, and the pro-apoptotic gene Bax. Eur J Neurosci 24(8):2105-17. PubMed: 17042795 MGI: J:116994
Wolpaw AJ; Shimada K; Skouta R; Welsch ME; Akavia UD; Pe'er D; Shaik F; Bulinski JC; Stockwell BR. 2011. Modulatory profiling identifies mechanisms of small molecule-induced cell death. Proc Natl Acad Sci U S A 108(39):E771-80. PubMed: 21896738 MGI: J:176584
Xiang C; Zhang KH; Yin J; Arends JJ; Erzurumlu RS; Jacquin MF; Chen ZF. 2010. The transcription factor, Lmx1b, is necessary for the development of the principal trigeminal nucleus-based lemniscal pathway. Mol Cell Neurosci 44(4):394-403. PubMed: 20621716 MGI: J:164254
Xiang CX; Zhang KH; Johnson RL; Jacquin MF; Chen ZF. 2012. The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex. Somatosens Mot Res 29(1):1-12. PubMed: 22397680 MGI: J:200736
Xiang J; Rir-Sim-Ah J; Tesfaigzi Y. 2008. IL-9 and IL-13 induce mucous cell metaplasia that is reduced by IFN-gamma in a Bax-mediated pathway. Am J Respir Cell Mol Biol 38(3):310-7. PubMed: 17901408 MGI: J:146356
Xu X; Qiao W; Linke SP; Cao L; Li WM; Furth PA; Harris CC; Deng CX. 2001. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet 28(3):266-71. PubMed: 11431698 MGI: J:70271
Xu Z; Sharp PP; Yao Y; Segal D; Ang CH; Khaw SL; Aubrey BJ; Gong J; Kelly GL; Herold MJ; Strasser A; Roberts AW; Alexander WS; Burns CJ; Huang DC; Glaser SP. 2016. BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells. Leukemia 30(7):1531-41. PubMed: 27055867 MGI: J:232796
Yamauchi J; Kumar A; Duarte L; Mehuron T; Girgenrath M. 2013. Triggering regeneration and tackling apoptosis: a combinatorial approach to treating congenital muscular dystrophy type 1 A. Hum Mol Genet 22(21):4306-17. PubMed: 23773998 MGI: J:202292
Yang L; Bula D; Arroyo JG; Chen DF. 2004. Preventing retinal detachment-associated photoreceptor cell loss in Bax-deficient mice. Invest Ophthalmol Vis Sci 45(2):648-54. PubMed: 14744910 MGI: J:109756
Yee KS; Wilkinson S; James J; Ryan KM; Vousden KH. 2009. PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death Differ 16(8):1135-45. PubMed: 19300452 MGI: J:164186
Yin C; Knudson CM; Korsmeyer SJ; Van Dyke T. 1997. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385(6617):637-40. PubMed: 9024662 MGI: J:38331
Zaman F; Chrysis D; Huntjens K; Fadeel B; Savendahl L. 2012. Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment. PLoS One 7(3):e33168. PubMed: 22442678 MGI: J:187038
Zeng Q; Kwan A; Oakley B. 2000. Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells. J Comp Neurol 424(4):640-50. PubMed: 10931486 MGI: J:63729
Zhao Y; Li S; Childs EE; Kuharsky DK; Yin XM. 2001. Activation of pro-death bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha -induced liver injury. J Biol Chem 276(29):27432-40. PubMed: 11369777 MGI: J:70549
Zhu X; Libby RT; de Vries WN; Smith RS; Wright DL; Bronson RT; Seburn KL; John SW. 2012. Mutations in a P-type ATPase gene cause axonal degeneration. PLoS Genet 8(8):e1002853. PubMed: 22912588 MGI: J:188127
Zhu Y; Liu X; Hildeman D; Peyerl FW; White J; Kushnir E; Kappler J; Marrack P. 2006. Bax does not have to adopt its final form to drive T cell death. J Exp Med 203(5):1147-52. PubMed: 16651384 MGI: J:124139
Zhuang Y; Berens-Norman HM; Leser JS; Clarke P; Tyler KL. 2016. Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis. J Virol 90(17):7684-91. PubMed: 27307572 MGI: J:235951
Zong WX; Ditsworth D; Bauer DE; Wang ZQ; Thompson CB. 2004. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18(11):1272-82. PubMed: 15145826 MGI: J:118568
de Nooij JC; Doobar S; Jessell TM. 2013. Etv1 inactivation reveals proprioceptor subclasses that reflect the level of NT3 expression in muscle targets. Neuron 77(6):1055-68. PubMed: 23522042 MGI: J:197913
de Rivero Vaccari JC; Casey GP; Aleem S; Park WM; Corriveau RA. 2006. NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death. Proc Natl Acad Sci U S A 103(45):16971-6. PubMed: 17077143 MGI: J:117103
de Vries GJ; Jardon M; Reza M; Rosen GJ; Immerman E; Forger NG. 2008. Sexual differentiation of vasopressin innervation of the brain: cell death versus phenotypic differentiation. Endocrinology 149(9):4632-7. PubMed: 18499746 MGI: J:145504

Also Known As: Bax-

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

Baxtm1Sjk

Allele Symbol: Baxtm1Sjk

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Baxtm1Sjk related

Mammalian Phenotype Terms by Genotype

Genotype: Baxtm1Sjk/Baxtm1SjkB6.129X1-Baxtm1Sjk/J

cellular phenotype

reproductive system phenotype

growth/size/body region phenotype

nervous system phenotype

endocrine/exocrine gland phenotype

Genotype: Baxtm1Sjk/Bax+involves: 129X1/SvJ

nervous system phenotype

Genotype: Baxtm1Sjk/Baxtm1Sjkinvolves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

nervous system phenotype

cellular phenotype

Genotype: Baxtm1Sjk/Baxtm1Sjkinvolves: 129X1/SvJ

endocrine/exocrine gland phenotype

hematopoietic system phenotype

immune system phenotype

reproductive system phenotype

nervous system phenotype

cellular phenotype

Genotype: Baxtm1Sjk/Baxtm1Sjkinvolves: 129X1/SvJ * C57BL/6

endocrine/exocrine gland phenotype

nervous system phenotype

reproductive system phenotype

Genotype: Bak1tm1Thsn/Bak1tm1Thsn Baxtm1Sjk/Baxtm1Sjkinvolves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6

mortality/aging

homeostasis/metabolism phenotype

limbs/digits/tail phenotype

reproductive system phenotype

behavior/neurological phenotype

hearing/vestibular/ear phenotype

hematopoietic system phenotype

immune system phenotype

nervous system phenotype

cellular phenotype

References

Additional References

Additional - Baxtm1Sjk related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Animal Health Reports

Live Mouse

Breeder Pair

Cryorecovery - Pricing

Progeny testing is not required

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Additional Use Restrictions Apply

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Also Known As: Bax^-

Bax^tm1Sjk

Allele Symbol: Bax^tm1Sjk

Genotype: Bax^tm1Sjk related

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
B6.129X1-Bax^tm1Sjk/J

Genotype: Bax^tm1Sjk/Bax⁺
involves: 129X1/SvJ

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129X1/SvJ

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129X1/SvJ * C57BL/6

Genotype: Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm1Sjk
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6

Additional - Bax^tm1Sjk related