JAX Mouse Strain Datasheet - 002994

B6.129X1-Bax^tm1Sjk/J

Stock No:: 002994 |; Bax^-

Repository Live

Overview

Also Known As: Bax^-

Homozygous Bax^tm1Sjk mice display aberrant apoptosis with hyperplasia displayed in various tissues, including thymocytes, B cells, and cells of the reproductive organs.

Donating Investigator

Dr. Stanley J. Korsmeyer, Dana-Farber Cancer Institute

Genetic overview

Genetic Background	Generation
C57BL/6	N21+N1F9 (27-MAR-17)

Bax^tm1Sjk

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Bax	BCL2-associated X protein

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Research Applications

Apoptosis Research
Cancer Research
Developmental Biology Research
Immunology, Inflammation and Autoimmunity Research
Reproductive Biology Research

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Base Price

Starting at:

$255.00 Domestic price for female

$510.00 Domestic price for breeder pair

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Details

Detailed Description

Mice homozygous for the Bax^tm1Sjk mutation are viable but display lineage-specific aberrations in cell death. Thymocytes and B cells from homozygous mutant mice display hyperplasia. Ovaries contain unusual atretic follicles with excess granulosa cells while Bax-deficient males are infertile. There is an accumulation of atypical premeiotic germ cells and no mature haploid sperm found in seminiferous tubules. Multinucleated giant cells and dysplastic cells accompany massive cell death.

Used in conjunction with strain B6.129-Bak1^tm1Thsn/J (see Stock No. 004183), to generate the double knock-out Bak/Bax, a model for demonstrating severe defects in the regulation of apoptosis during development and tissue homeostasis.

Coat color of Bax^tm1Sjk mice
The coat color loci tyrosinase (Tyr) and pink-eyed dilution (p) are linked to the Bcl2-associated X protein (Bax) gene. According to backcross data from the Mouse Genome Database, Bax is at 23.00 cM, p is at 28.00 cM, and Tyr is at 44.00 cM on chromosome 7. The targeted disruption of the Bax gene was performed in a 129-derived RW-4 ES cell line (A^w/A^w p Tyr^c-ch/p Tyr^c) and has been backcrossed 8 generations to C57BL/6 (a/a +^p +^Tyr-c/+^p +^Tyr-c; nonagouti black). Statistically, C57BL/6J-Bax^tm1Sjk mice (Stock No. 002994) should be 99.6% C57BL/6-like at all loci not linked to the Bax gene. At the present time The Jackson Laboratory's colony of C57BL/6J-Bax^tm1Sjkmice are stillsegregating at the Tyr locus and retain the p allele from the 129 ES cell line. Thus, matings of Bax heterozygous (+/-) mice may produce progeny of varying coat color including black, white, chinchilla, light chinchilla, or grey, with all but the black mice having pink eyes. Because the potential for crossover between the p and Bax loci is small (roughly 5%), progeny that are grey in color and have pink eyes most likely are homozygous for the targeted Bax gene (-/-). However, we strongly recommend that you confirm the genotype of the mice prior to using them for research purposes. The Jackson Laboratory is continuing to backcross the Bax targeted mutation to C57BL/6J to try to eliminate the recessive 129 alleles of Tyr and p. However, in an effort to make these mice available to the research community as soon as possible we will begin distribution of the current colony. To summarize, the C57BL/6J-Bax^tm1Sjkmice (Stock No. 002994) have been backcrossed 8 generations to the C57BL/6J inbred strain. However, because of coat color genes linked to the Bax mutation breeder pairs supplied by The Jackson Laboratory may produce progeny of varying coat color.

Development

A Bax targeting vector substituted PGK-Neo for exons 2 through 5, deleting BH1 and BH2 and the capacity for a functional protein.

Control Suggestions

Wild-type from the colony
000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Knudson CM; Tung KS; Tourtellotte WG; Brown GA; Korsmeyer SJ. 1995. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270(5233):96-9. PubMed: 7569956 MGI: J:29253

View All References

Genetics

Bax^tm1Sjk

Allele Symbol: Bax^tm1Sjk

Allele Name	targeted mutation 1, Stanley J Korsmeyer
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	Bax1; Bax^-
Gene Symbol and Name	Bax, BCL2-associated X protein
Gene Synonym(s)	BCL2L4
Strain of Origin	129X1/SvJ
Chromosome	7
Molecular Note	A neomycin selection cassette replaced exons 2 through 4 and part of exon 5, which encode sequences that correspond to the two BCL2 homology domains BH1 and BH2. Immunoblots did not detect the endcoded protein in tissue lysates derived from homozygous mice.
Mutations Made By	Dr. Stanley Korsmeyer, Dana-Farber Cancer Institute

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Bax^tm1Sjk related

Apoptosis Research
- Endogenous Regulators
Cancer Research
- Genes Regulating Growth and Proliferation
Developmental Biology Research
- Internal/Organ Defects
  - gonads
Immunology, Inflammation and Autoimmunity Research
- Intracellular Signaling Molecules
Reproductive Biology Research
- Developmental Defects Affecting Gonads
- Fertility Defects

Mammalian Phenotype Terms by Genotype

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
B6.129X1-Bax^tm1Sjk/J

cellular phenotype

azoospermia

reproductive system phenotype

abnormal seminiferous tubule morphology
- some tubules have an accumulation of early germ cells while others have fewer germ cells than normal
- the spermatogonia layer is thicker than in wild-type being up to 3 cell layers thick

abnormal spermatogenesis
- at P15 the number of germ cells in the testis is increased and these are mostly c-Kit+ early germ cells, but in adult males the number of germ cells is decreased by up to 10-fold compared to wild-type

arrest of male meiosis
- arrests before the completion of meiosis in the preleptotene spermatocyte stage

azoospermia

decreased testis weight
- in adults testes weigh about 60% that of wild-type

male infertility
- males but not females are sterile

growth/size/body region phenotype

decreased body weight
- seen in about 50% of mice

nervous system phenotype

nervous system phenotype
- cultured enteric neurons from Bax-deficient embryos that are GDNF-deprived show no significant differences in survival relative to enteric neurons from conditionally-inactivated Gfra1-null mice

endocrine/exocrine gland phenotype

abnormal seminiferous tubule morphology
- some tubules have an accumulation of early germ cells while others have fewer germ cells than normal
- the spermatogonia layer is thicker than in wild-type being up to 3 cell layers thick

decreased testis weight
- in adults testes weigh about 60% that of wild-type

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Bax^tm1Sjk/Bax⁺
involves: 129X1/SvJ

nervous system phenotype

abnormal sympathetic neuron morphology
- cultures of sympathetic neurons grown in the presence of NGF before being deprived of NGF, die with slower kinetics than wild-type, such that after 8 days, 14% of neurons remain viable compared to none in controls

increased motor neuron number
- modest 13% increase in the total number of facial motor neurons at 4 weeks of age relative to wild-type

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

nervous system phenotype

abnormal axon extension
- neurite outgrowth is significantly less than that of Isl1^tm1(cre)Cos Mapt^{tm1(Ewsr1/Etv4)Arbr} heterozygotes with or without treatment with neurotrphin-3

abnormal dorsal root ganglion morphology
- dorsal root ganglia neurons survive without neurotrophic factors

increased sensory neuron number
- apoptosis rates are decreased resulting in increased number of neurons in the lumbar dorsal root ganglia (170% of wild-type numbers)

cellular phenotype

abnormal axon extension
- neurite outgrowth is significantly less than that of Isl1^tm1(cre)Cos Mapt^{tm1(Ewsr1/Etv4)Arbr} heterozygotes with or without treatment with neurotrphin-3

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129X1/SvJ

endocrine/exocrine gland phenotype

abnormal ovarian follicle morphology
- atretic follicles with excess granulosa cells

abnormal seminiferous tubule morphology
- disordered

increased thymocyte number
- 1.6 fold increase in thymocyte number relative to wild-type
- normal distribution of maturational subsets (CD4-CD8-, CD4+CD8+, CD4+, CD8+ cells)

hematopoietic system phenotype

enlarged spleen

increased B cell number

increased thymocyte number
- 1.6 fold increase in thymocyte number relative to wild-type
- normal distribution of maturational subsets (CD4-CD8-, CD4+CD8+, CD4+, CD8+ cells)

immune system phenotype

enlarged spleen

increased B cell number

increased thymocyte number
- 1.6 fold increase in thymocyte number relative to wild-type
- normal distribution of maturational subsets (CD4-CD8-, CD4+CD8+, CD4+, CD8+ cells)

reproductive system phenotype

abnormal male germ cell apoptosis
- increased male germ cell apoptosis

abnormal ovarian follicle morphology
- atretic follicles with excess granulosa cells

abnormal seminiferous tubule morphology
- disordered

arrest of spermatogenesis
- accumulation of premeiotic germ cells

azoospermia
- absence of sperm in the epididymis and vas deferens

male infertility

nervous system phenotype

abnormal facial motor nucleus morphology
- mutants exhibit a large reduction in motor neuron death in the facial nucleus following neonatal axotomy compared to wild-type

abnormal phrenic nerve morphology
- the phrenic nerve is thicker in mutants, however neuromuscular synapses were normal

abnormal proprioceptive neuron morphology
- about 30% of pSNs in the rostral lumbar DRG have cell body diameters in the wild-type range, with 70% having smaller somatic diameters

abnormal superior cervical ganglion morphology
- superior cervical ganglion of neonates contains 2.5 and 1.8 times more neurons than wild-type and heterozygous ganglia, respectively

abnormal sympathetic neuron morphology
- sympathetic neurons from superior cervical ganglion show a dramatic reduction of death after trophic factor (NGF) deprivation

decreased neuron apoptosis
- developmental sympathetic and motor neuronal death is reduced

increased motor neuron number
- contralateral nonaxotomized facial nucleus shows a 51% increase in neuronal number relative to wild-type at 4 weeks of age
- mutants display an increase in the number of small- to medium-sized motor neurons

increased sensory neuron number
- number of proprioceptive sensory neurons (pSNs) is increased by 2-fold compared to wild-type controls

nervous system phenotype
- mice exhibit normal mammary gland innervation

cellular phenotype

abnormal male germ cell apoptosis
- increased male germ cell apoptosis

azoospermia
- absence of sperm in the epididymis and vas deferens

decreased neuron apoptosis
- developmental sympathetic and motor neuronal death is reduced

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129X1/SvJ * C57BL/6

endocrine/exocrine gland phenotype

abnormal ovarian folliculogenesis
- follicles persisted in aged females (20 to 22 months old)
- increased number of follicles observed at 42 days
- reduced incidence of atresia of primordial and primary follicles relative to wild-type

increased mature ovarian follicle number
- increased number of follicles observed at 42 days of age
- persistence of hundreds of follicles of all developmental stages in aged females (20 to 22 months old)

nervous system phenotype

abnormal dorsal root ganglion morphology
- the number of dorsal root ganglia neurons in L4 is increased relative to in wild-type mice

reproductive system phenotype

abnormal ovarian folliculogenesis
- follicles persisted in aged females (20 to 22 months old)
- increased number of follicles observed at 42 days
- reduced incidence of atresia of primordial and primary follicles relative to wild-type

increased mature ovarian follicle number
- increased number of follicles observed at 42 days of age
- persistence of hundreds of follicles of all developmental stages in aged females (20 to 22 months old)

uterus hypertrophy
- ovarian steroid-driven uternine hypertrophy is observed in aged females (20 to 22 months old)

The following phenotype relates to a compound genotype created using this strain

Genotype: Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm1Sjk
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6

mortality/aging

neonatal lethality, incomplete penetrance
- majority die within 48 hours of birth, although some survive to adulthood

homeostasis/metabolism phenotype

decreased physiological sensitivity to xenobiotic
- thymocytes are resistant to treatment with etoposide, a chemotherapeutic agent that normally induces cell death

limbs/digits/tail phenotype

interdigital webbing
- mutants retain interdigital webs on both fore and rear paws

reproductive system phenotype

vagina atresia
- seen in all adult females

behavior/neurological phenotype

circling
- display circling behavior when exposed to external stress

seizures
- stress-induced seizure activity

hearing/vestibular/ear phenotype

abnormal hearing physiology
- unresponsive to auditory stimuli

hematopoietic system phenotype

abnormal B cell morphology
- B220+ B cells present in the lymph node and spleen are skewed toward a B220^brightIgD- phenotype, indicating an increase in the number of class-switched or memory B cells

abnormal T cell morphology
- T cells that accumulate in mutants are skewed toward a memory cell phenotype

abnormal definitive hematopoiesis
- hematopoietic colony assays show an increase in the number of myeloid colony forming units and a mild increase in erythroid and megakaryocyte colony forming units

abnormal splenocyte physiology
- isolated splenocytes cultured in suspension show enhanced survival

anemia
- mild anemia

enlarged spleen

increased leukocyte cell number

increased lymphocyte cell number
- increases within the circulation and the peripheral lymphoid organs
- lymphocytic infiltration is seen in parenchymal organs, liver, and kidney

increased spleen red pulp amount
- expanded red pulp contains a large increase in the number of plasma cells and histiocytes

increased spleen white pulp amount
- pronounced hyperplasia

thrombocytopenia

immune system phenotype

abnormal B cell morphology
- B220+ B cells present in the lymph node and spleen are skewed toward a B220^brightIgD- phenotype, indicating an increase in the number of class-switched or memory B cells

abnormal T cell morphology
- T cells that accumulate in mutants are skewed toward a memory cell phenotype

abnormal splenocyte physiology
- isolated splenocytes cultured in suspension show enhanced survival

enlarged lymph nodes

enlarged spleen

increased leukocyte cell number

increased lymphocyte cell number
- increases within the circulation and the peripheral lymphoid organs
- lymphocytic infiltration is seen in parenchymal organs, liver, and kidney

increased spleen red pulp amount
- expanded red pulp contains a large increase in the number of plasma cells and histiocytes

increased spleen white pulp amount
- pronounced hyperplasia

nervous system phenotype

abnormal brain morphology
- increase in the number of neurons in multiple regions of the brain
- large accumulation of small neuronal cells (neural stem cells) with dense chromatin staining in the periventricular region

increased brain size

increased neuron number
- in multiple regions of the brain

seizures
- stress-induced seizure activity

cellular phenotype

decreased cellular sensitivity to gamma-irradiation
- thymocytes show enhanced survival compared to wild-type when exposed to gamma irradiation

References

Knudson CM; Tung KS; Tourtellotte WG; Brown GA; Korsmeyer SJ. 1995. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270(5233):96-9. PubMed: 7569956 MGI: J:29253

Additional References

Forger NG; Rosen GJ; Waters EM; Jacob D; Simerly RB; de Vries GJ. 2004. Deletion of Bax eliminates sex differences in the mouse forebrain. Proc Natl Acad Sci U S A 101(37):13666-71. PubMed: 15342910 MGI: J:92614
Khaled AR; Li WQ; Huang J; Fry TJ; Khaled AS; Mackall CL; Muegge K; Young HA; Durum SK. 2002. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity 17(5):561-73. PubMed: 12433363 MGI: J:93139
Knudson CM; Korsmeyer SJ. 1997. Bcl-2 and Bax function independently to regulate cell death. Nat Genet 16(4):358-63. PubMed: 9241272 MGI: J:42051
Lu YP; Lou YR; Peng QY; Xie JG; Conney AH. 2004. Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice. Cancer Res 64(14):5020-7. PubMed: 15256477 MGI: J:91506
Yin C; Knudson CM; Korsmeyer SJ; Van Dyke T. 1997. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385(6617):637-40. PubMed: 9024662 MGI: J:38331

Additional - Bax^tm1Sjk related

Abdo H; Li L; Lallemend F; Bachy I; Xu XJ; Rice FL; Ernfors P. 2011. Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci 34(10):1529-41. PubMed: 22103411 MGI: J:184160
Adlaf EW; Vaden RJ; Niver AJ; Manuel AF; Onyilo VC; Araujo MT; Dieni CV; Vo HT; King GD; Wadiche JI; Overstreet-Wadiche L. 2017. Adult-born neurons modify excitatory synaptic transmission to existing neurons. Elife 6:. PubMed: 28135190 MGI: J:240945
Alton M; Taketo T. 2007. Switch from BAX-dependent to BAX-independent germ cell loss during the development of fetal mouse ovaries. J Cell Sci 120(Pt 3):417-24. PubMed: 17213335 MGI: J:120767
Anderson MJ; Schimmang T; Lewandoski M. 2016. An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. PLoS Genet 12(5):e1006018. PubMed: 27144312 MGI: J:232560
Armstrong A; Ryu YK; Chieco D; Kuruvilla R. 2011. Frizzled3 Is Required for Neurogenesis and Target Innervation during Sympathetic Nervous System Development. J Neurosci 31(7):2371-81. PubMed: 21325504 MGI: J:169444
Bailey DP; Kashyap M; Bouton LA; Murray PJ; Ryan JJ. 2006. Interleukin-10 induces apoptosis in developing mast cells and macrophages. J Leukoc Biol 80(3):581-9. PubMed: 16829633 MGI: J:112579
Baines CP; Kaiser RA; Sheiko T; Craigen WJ; Molkentin JD. 2007. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 9(5):550-5. PubMed: 17417626 MGI: J:129616
Barone MC; Desouza LA; Freeman RS. 2008. Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity. J Neurochem 106(2):734-45. PubMed: 18419764 MGI: J:139389
Ben-Zvi A; Manor O; Schachner M; Yaron A; Tessier-Lavigne M; Behar O. 2008. The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development. J Neurosci 28(47):12427-32. PubMed: 19020035 MGI: J:142362
Ben-Zvi A; Sweetat S; Behar O. 2013. Elimination of aberrant DRG circuitries in Sema3A mutant mice leads to extensive neuronal deficits. PLoS One 8(7):e70085. PubMed: 23922915 MGI: J:204365
Berens HM; Tyler KL. 2011. The pro-apoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis. J Virol :. PubMed: 21307199 MGI: J:168899
Bernal NP; Stehr W; Coyle R; Erwin CR; Warner BW. 2006. Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice. Gastroenterology 130(2):412-23. PubMed: 16472596 MGI: J:124922
Bouilloux F; Thireau J; Venteo S; Farah C; Karam S; Dauvilliers Y; Valmier J; Copeland NG; Jenkins NA; Richard S; Marmigere F. 2016. Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. Elife 5:. PubMed: 26857994 MGI: J:230425
Bruce FM; Brown S; Smith JN; Fuerst PG; Erskine L. 2017. DSCAM promotes axon fasciculation and growth in the developing optic pathway. Proc Natl Acad Sci U S A 114(7):1702-1707. PubMed: 28137836 MGI: J:240943
Bruckheimer EM; Cho S; Brisbay S; Johnson DJ; Gingrich JR; Greenberg N; McDonnell TJ. 2000. The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo. Oncogene 19(20):2404-12. PubMed: 10828882 MGI: J:62297
Buss RR; Gould TW; Ma J; Vinsant S; Prevette D; Winseck A; Toops KA; Hammarback JA; Smith TL; Oppenheim RW. 2006. Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle. J Neurosci 26(52):13413-27. PubMed: 17192424 MGI: J:117220
Bustamante-Marin XM; Cook MS; Gooding J; Newgard C; Capel B. 2015. Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites. Biol Reprod 93(3):78. PubMed: 26224005 MGI: J:226269
Chang MY; Sun W; Ochiai W; Nakashima K; Kim SY; Park CH; Kang JS; Shim JW; Jo AY; Kang CS; Lee YS; Kim JS; Lee SH. 2007. Bcl-XL/Bax proteins direct the fate of embryonic cortical precursor cells. Mol Cell Biol 27(12):4293-305. PubMed: 17438128 MGI: J:122346
Chao JR; Parganas E; Boyd K; Hong CY; Opferman JT; Ihle JN. 2008. Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature 452(7183):98-102. PubMed: 18288109 MGI: J:132627
Chavez-Reyes A; Parant JM; Amelse LL; de Oca Luna RM; Korsmeyer SJ; Lozano G. 2003. Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Res 63(24):8664-9. PubMed: 14695178 MGI: J:87065
Chen HC; Kanai M; Inoue-Yamauchi A; Tu HC; Huang Y; Ren D; Kim H; Takeda S; Reyna DE; Chan PM; Ganesan YT; Liao CP; Gavathiotis E; Hsieh JJ; Cheng EH. 2015. An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nat Cell Biol 17(10):1270-81. PubMed: 26344567 MGI: J:227510
Chen L; Faire M; Kissner MD; Laird DJ. 2013. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet 22(2):313-27. PubMed: 23077213 MGI: J:191131
Chen WV; Alvarez FJ; Lefebvre JL; Friedman B; Nwakeze C; Geiman E; Smith C; Thu CA; Tapia JC; Tasic B; Sanes JR; Maniatis T. 2012. Functional significance of isoform diversification in the protocadherin gamma gene cluster. Neuron 75(3):402-9. PubMed: 22884324 MGI: J:188341
Cheung EC; Melanson-Drapeau L; Cregan SP; Vanderluit JL; Ferguson KL; McIntosh WC; Park DS; Bennett SA; Slack RS. 2005. Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. J Neurosci 25(6):1324-34. PubMed: 15703386 MGI: J:98103
Chi MM; Pingsterhaus J; Carayannopoulos M; Moley KH. 2000. Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst J Biol Chem 275(51):40252-7. PubMed: 10995754 MGI: J:66414
Chi MM; Schlein AL; Moley KH. 2000. High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the IGF-1 receptor. Endocrinology 141(12):4784-92. PubMed: 11108294 MGI: J:115385
Choi S; Chen Z; Tang LH; Fang Y; Shin SJ; Panarelli NC; Chen YT; Li Y; Jiang X; Du YC. 2016. Bcl-xL promotes metastasis independent of its anti-apoptotic activity. Nat Commun 7:10384. PubMed: 26785948 MGI: J:235886
Chong MJ; Murray MR; Gosink EC; Russell HR; Srinivasan A; Kapsetaki M; Korsmeyer SJ; McKinnon PJ. 2000. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc Natl Acad Sci U S A 97(2):889-94. PubMed: 10639175 MGI: J:59934
Cleland MM; Norris KL; Karbowski M; Wang C; Suen DF; Jiao S; George NM; Luo X; Li Z; Youle RJ. 2011. Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ 18(2):235-47. PubMed: 20671748 MGI: J:186336
Clemente EJ; Furlong RA; Loveland KL; Affara NA. 2006. Gene expression study in the juvenile mouse testis: identification of stage-specific molecular pathways during spermatogenesis. Mamm Genome 17(9):956-75. PubMed: 16964443 MGI: J:112872
Cook MS; Coveney D; Batchvarov I; Nadeau JH; Capel B. 2009. BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. Dev Biol 328(2):377-83. PubMed: 19389346 MGI: J:149469
Cook MS; Munger SC; Nadeau JH; Capel B. 2011. Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. Development 138(1):23-32. PubMed: 21115610 MGI: J:167041
Coulpier M; Messiaen S; Hamel R; Fernandez de Marco M; Lilin T; Eloit M. 2006. Bax deletion does not protect neurons from BSE-induced death. Neurobiol Dis 23(3):603-11. PubMed: 16854590 MGI: J:147030
Coultas L; Bouillet P; Loveland KL; Meachem S; Perlman H; Adams JM; Strasser A. 2005. Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis. EMBO J 24(22):3963-73. PubMed: 16270031 MGI: J:103605
Crowther AJ; Gama V; Bevilacqua A; Chang SX; Yuan H; Deshmukh M; Gershon TR. 2013. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci 33(46):18098-108. PubMed: 24227720 MGI: J:204171
D'Orsi B; Bonner H; Tuffy LP; Dussmann H; Woods I; Courtney MJ; Ward MW; Prehn JH. 2012. Calpains are downstream effectors of bax-dependent excitotoxic apoptosis. J Neurosci 32(5):1847-58. PubMed: 22302823 MGI: J:181340
D'Orsi B; Engel T; Pfeiffer S; Nandi S; Kaufmann T; Henshall DC; Prehn JH. 2016. Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury. J Neurosci 36(16):4564-78. PubMed: 27098698 MGI: J:235305
D'Orsi B; Kilbride SM; Chen G; Perez Alvarez S; Bonner HP; Pfeiffer S; Plesnila N; Engel T; Henshall DC; Dussmann H; Prehn JH. 2015. Bax regulates neuronal Ca2+ homeostasis. J Neurosci 35(4):1706-22. PubMed: 25632145 MGI: J:218973
Dansen TB; Whitfield J; Rostker F; Brown-Swigart L; Evan GI. 2006. Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo. J Biol Chem 281(16):10890-5. PubMed: 16464852 MGI: J:108676
Dargusch R; Piasecki D; Tan S; Liu Y; Schubert D. 2001. The role of Bax in glutamate-induced nerve cell death. J Neurochem 76(1):295-301. PubMed: 11146002 MGI: J:68970
Deckwerth TL; Easton RM; Knudson CM; Korsmeyer SJ; Johnson EM Jr. 1998. Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. Exp Neurol 152(1):150-62. PubMed: 9682022 MGI: J:179272
Deckwerth TL; Elliott JL; Knudson CM; Johnson EM Jr; Snider WD; Korsmeyer SJ. 1996. BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17(3):401-11. PubMed: 8816704 MGI: J:35372
Degenhardt K; Sundararajan R; Lindsten T; Thompson C; White E. 2002. Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem 277(16):14127-34. PubMed: 11836241 MGI: J:76058
Dejean LM; Martinez-Caballero S; Guo L; Hughes C; Teijido O; Ducret T; Ichas F; Korsmeyer SJ; Antonsson B; Jonas EA; Kinnally KW. 2005. Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell 16(5):2424-32. PubMed: 15772159 MGI: J:100217
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Speiran K; Bailey DP; Fernando J; Macey M; Barnstein B; Kolawole M; Curley D; Watowich SS; Murray PJ; Oskeritzian C; Ryan JJ. 2009. Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol 85(5):826-36. PubMed: 19228815 MGI: J:149777
Stallock J; Molyneaux K; Schaible K; Knudson CM; Wylie C. 2003. The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo. Development 130(26):6589-97. PubMed: 14660547 MGI: J:86513
Steckley D; Karajgikar M; Dale LB; Fuerth B; Swan P; Drummond-Main C; Poulter MO; Ferguson SS; Strasser A; Cregan SP. 2007. Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci 27(47):12989-99. PubMed: 18032672 MGI: J:127640
Steele AD; King OD; Jackson WS; Hetz CA; Borkowski AW; Thielen P; Wollmann R; Lindquist S. 2007. Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. J Neurosci 27(47):13022-7. PubMed: 18032675 MGI: J:141553
Steimer DA; Boyd K; Takeuchi O; Fisher JK; Zambetti GP; Opferman JT. 2009. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood 113(12):2805-15. PubMed: 19064728 MGI: J:146310
Su H; Marcheva B; Meng S; Liang FA; Kohsaka A; Kobayashi Y; Xu AW; Bass J; Wang X. 2010. Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice. Dev Biol 339(1):38-50. PubMed: 20025866 MGI: J:157958
Sun W; Gould TW; Vinsant S; Prevette D; Oppenheim RW. 2003. Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion. J Neurosci 23(19):7298-310. PubMed: 12917363 MGI: J:88191
Sun W; Oppenheim RW. 2003. Response of motoneurons to neonatal sciatic nerve axotomy in Bax-knockout mice. Mol Cell Neurosci 24(4):875-86. PubMed: 14697655 MGI: J:87200
Sun W; Winseck A; Vinsant S; Park OH; Kim H; Oppenheim RW. 2004. Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax. J Neurosci 24(49):11205-13. PubMed: 15590937 MGI: J:96804
Suo D; Park J; Harrington AW; Zweifel LS; Mihalas S; Deppmann CD. 2014. Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat Neurosci 17(1):36-45. PubMed: 24270184 MGI: J:207835
Suzuki A; Igarashi K; Aisaki K; Kanno J; Saga Y. 2010. NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs. Proc Natl Acad Sci U S A 107(8):3594-9. PubMed: 20133598 MGI: J:157579
Suzuki A; Saga Y. 2008. Nanos2 suppresses meiosis and promotes male germ cell differentiation. Genes Dev 22(4):430-5. PubMed: 18281459 MGI: J:132711
Suzuki H; Aoyama Y; Senzaki K; Vincler M; Wittenauer S; Yoshikawa M; Ozaki S; Oppenheim RW; Shiga T. 2010. Characterization of sensory neurons in the dorsal root ganglia of Bax-deficient mice. Brain Res 1362:23-31. PubMed: 20846512 MGI: J:166957
Suzuki H; Tsuda M; Kiso M; Saga Y. 2008. Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev Biol 318(1):133-42. PubMed: 18436203 MGI: J:136687
Takeuchi O; Fisher J; Suh H; Harada H; Malynn BA; Korsmeyer SJ. 2005. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A 102(32):11272-7. PubMed: 16055554 MGI: J:100463
Tanaka T; Wakabayashi T; Oizumi H; Nishio S; Sato T; Harada A; Fujii D; Matsuo Y; Hashimoto T; Iwatsubo T. 2014. CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. J Neurosci 34(4):1370-9. PubMed: 24453327 MGI: J:206855
Tesfaigzi Y; Fischer MJ; Daheshia M; Green FH; De Sanctis GT; Wilder JA. 2002. Bax is crucial for IFN-gamma-induced resolution of allergen-induced mucus cell metaplasia. J Immunol 169(10):5919-25. PubMed: 12421976 MGI: J:80074
Tessner TG; Muhale F; Riehl TE; Anant S; Stenson WF. 2004. Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J Clin Invest 114(11):1676-85. PubMed: 15578100 MGI: J:94433
Tian H; Ma M. 2008. Activity plays a role in eliminating olfactory sensory neurons expressing multiple odorant receptors in the mouse septal organ. Mol Cell Neurosci 38(4):484-8. PubMed: 18538580 MGI: J:141795
Uesaka T; Enomoto H. 2010. Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice. J Neurosci 30(15):5211-8. PubMed: 20392943 MGI: J:159854
Uesaka T; Jain S; Yonemura S; Uchiyama Y; Milbrandt J; Enomoto H. 2007. Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development 134(11):2171-81. PubMed: 17507417 MGI: J:122607
Uo T; Kinoshita Y; Morrison RS. 2007. Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons. J Neurosci 27(45):12198-210. PubMed: 17989286 MGI: J:127443
Upton JP; Austgen K; Nishino M; Coakley KM; Hagen A; Han D; Papa FR; Oakes SA. 2008. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol 28(12):3943-51. PubMed: 18426910 MGI: J:137299
Vandenberg CJ; Josefsson EC; Campbell KJ; James C; Lawlor KE; Kile BT; Cory S. 2014. Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice. Cell Death Differ 21(5):676-84. PubMed: 24464220 MGI: J:229362
Vaughn AE; Deshmukh M. 2007. Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons. Cell Death Differ 14(5):973-81. PubMed: 17218959 MGI: J:139242
Vila M; Jackson-Lewis V; Vukosavic S; Djaldetti R; Liberatore G; Offen D; Korsmeyer SJ; Przedborski S. 2001. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 98(5):2837-42. PubMed: 11226327 MGI: J:67861
Villunger A; Scott C; Bouillet P; Strasser A. 2003. Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival. Blood 101(6):2393-400. PubMed: 12433687 MGI: J:82641
Vince JE; Wong WW; Gentle I; Lawlor KE; Allam R; O'Reilly L; Mason K; Gross O; Ma S; Guarda G; Anderton H; Castillo R; Hacker G; Silke J; Tschopp J. 2012. Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation. Immunity 36(2):215-27. PubMed: 22365665 MGI: J:181625
Wang X; Eno CO; Altman BJ; Zhu Y; Zhao G; Olberding KE; Rathmell JC; Li C. 2011. ER stress modulates cellular metabolism. Biochem J 435(1):285-96. PubMed: 21241252 MGI: J:170628
Weiner JA; Wang X; Tapia JC; Sanes JR. 2005. Gamma protocadherins are required for synaptic development in the spinal cord. Proc Natl Acad Sci U S A 102(1):8-14. PubMed: 15574493 MGI: J:95826
Weinlich R; Oberst A; Dillon CP; Janke LJ; Milasta S; Lukens JR; Rodriguez DA; Gurung P; Savage C; Kanneganti TD; Green DR. 2013. Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Rep 5(2):340-8. PubMed: 24095739 MGI: J:203778
Werth JL; Deshmukh M; Cocabo J; Johnson EM Jr; Rothman SM. 2000. Reversible physiological alterations in sympathetic neurons deprived of NGF but protected from apoptosis by caspase inhibition or Bax deletion. Exp Neurol 161(1):203-11. PubMed: 10683286 MGI: J:115320
White FA; Keller-Peck CR; Knudson CM; Korsmeyer SJ; Snider WD. 1998. Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. J Neurosci 18(4):1428-39. PubMed: 9454852 MGI: J:45764
White MJ; Schoenwaelder SM; Josefsson EC; Jarman KE; Henley KJ; James C; Debrincat MA; Jackson SP; Huang DC; Kile BT. 2012. Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood 119(18):4283-90. PubMed: 22294729 MGI: J:185011
Whitney IE; Raven MA; Ciobanu DC; Williams RW; Reese BE. 2009. Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina. Invest Ophthalmol Vis Sci 50(5):1996-2003. PubMed: 19168892 MGI: J:149703
Wickramasinghe SR; Alvania RS; Ramanan N; Wood JN; Mandai K; Ginty DD. 2008. Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron 58(4):532-45. PubMed: 18498735 MGI: J:145293
Winseck AK; Oppenheim RW. 2006. An in vivo analysis of Schwann cell programmed cell death in embryonic mice: the role of axons, glial growth factor, and the pro-apoptotic gene Bax. Eur J Neurosci 24(8):2105-17. PubMed: 17042795 MGI: J:116994
Wolpaw AJ; Shimada K; Skouta R; Welsch ME; Akavia UD; Pe'er D; Shaik F; Bulinski JC; Stockwell BR. 2011. Modulatory profiling identifies mechanisms of small molecule-induced cell death. Proc Natl Acad Sci U S A 108(39):E771-80. PubMed: 21896738 MGI: J:176584
Xiang C; Zhang KH; Yin J; Arends JJ; Erzurumlu RS; Jacquin MF; Chen ZF. 2010. The transcription factor, Lmx1b, is necessary for the development of the principal trigeminal nucleus-based lemniscal pathway. Mol Cell Neurosci 44(4):394-403. PubMed: 20621716 MGI: J:164254
Xiang CX; Zhang KH; Johnson RL; Jacquin MF; Chen ZF. 2012. The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex. Somatosens Mot Res 29(1):1-12. PubMed: 22397680 MGI: J:200736
Xiang J; Rir-Sim-Ah J; Tesfaigzi Y. 2008. IL-9 and IL-13 induce mucous cell metaplasia that is reduced by IFN-gamma in a Bax-mediated pathway. Am J Respir Cell Mol Biol 38(3):310-7. PubMed: 17901408 MGI: J:146356
Xu X; Qiao W; Linke SP; Cao L; Li WM; Furth PA; Harris CC; Deng CX. 2001. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet 28(3):266-71. PubMed: 11431698 MGI: J:70271
Xu Z; Sharp PP; Yao Y; Segal D; Ang CH; Khaw SL; Aubrey BJ; Gong J; Kelly GL; Herold MJ; Strasser A; Roberts AW; Alexander WS; Burns CJ; Huang DC; Glaser SP. 2016. BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells. Leukemia 30(7):1531-41. PubMed: 27055867 MGI: J:232796
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Also Known As: Bax-

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Baxtm1Sjk

Allele Symbol: Baxtm1Sjk

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This mouse can be used to support research in many areas including:

Genotype: Baxtm1Sjk related

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Genotype: Baxtm1Sjk/Baxtm1SjkB6.129X1-Baxtm1Sjk/J

cellular phenotype

reproductive system phenotype

growth/size/body region phenotype

nervous system phenotype

endocrine/exocrine gland phenotype

Genotype: Baxtm1Sjk/Bax+involves: 129X1/SvJ

nervous system phenotype

Genotype: Baxtm1Sjk/Baxtm1Sjkinvolves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

nervous system phenotype

cellular phenotype

Genotype: Baxtm1Sjk/Baxtm1Sjkinvolves: 129X1/SvJ

endocrine/exocrine gland phenotype

hematopoietic system phenotype

immune system phenotype

reproductive system phenotype

nervous system phenotype

cellular phenotype

Genotype: Baxtm1Sjk/Baxtm1Sjkinvolves: 129X1/SvJ * C57BL/6

endocrine/exocrine gland phenotype

nervous system phenotype

reproductive system phenotype

Genotype: Bak1tm1Thsn/Bak1tm1Thsn Baxtm1Sjk/Baxtm1Sjkinvolves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6

mortality/aging

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hearing/vestibular/ear phenotype

hematopoietic system phenotype

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cellular phenotype

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Also Known As: Bax^-

Bax^tm1Sjk

Allele Symbol: Bax^tm1Sjk

Genotype: Bax^tm1Sjk related

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
B6.129X1-Bax^tm1Sjk/J

Genotype: Bax^tm1Sjk/Bax⁺
involves: 129X1/SvJ

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129X1/SvJ

Genotype: Bax^tm1Sjk/Bax^tm1Sjk
involves: 129X1/SvJ * C57BL/6

Genotype: Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm1Sjk
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6

Additional - Bax^tm1Sjk related