These Ascl1 (formerly Mash-1) knock-out mice exhibit loss of sympathetic ganglia and olefactory epithelium. They are suitable for use in applications related to the study of nervous system development.
David J Anderson, California Institute of Technology
Mice homozygous for the Ascl1tm1And targeted mutation die within 24 hours after birth. There are no gross external defects; However, mutant mice do have extensive loss of sympathetic ganglia and olefactory epithelium.
|Allele Name||targeted mutation 1, David J Anderson|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||Ascl1delta; Mash-1-; Mash1-; Mash-1delta|
|Gene Symbol and Name||Ascl1, achaete-scute family bHLH transcription factor 1|
|Strain of Origin||129/Sv|
|General Note||ES cell line = D3 (129S2/SvPas) or R1 (129S1/Sv x 129X1/SvJ)F1. The authors state that most phenotypic analysis was done on R1-derived mice.|
|Molecular Note||A PGK-neomycin resistance cassette replaced the entire coding region, 0.6 kb of sequence 5' of the translation initiation codon, and 0.2 kb of sequence 3' of the translation termination codon.|
|Mutations Made By|| |
David Anderson, California Institute of Technology