JAX
Mouse Strain Datasheet - 002957
B6.129-Dll1tm1Gos/J
Also Known As: Dll1 KO
These Dll1 knock-out mice exhibit defects in the segmentation of mesoderm in the developing embryo. They are suitable for use in applications related to the study of somite formation and patterning during embryogenesis.
Donating Investigator
Dr. Achim Gossler, Medizinische Hochschule Hannover
Genetic overview
| Genetic Background | Generation |
|---|---|
|
000664 C57BL/6J |
|
Dll1tm1Gos
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout, Reporter) | Dll1 | delta-like 1 (Drosophila) |
Research Applications
- Developmental Biology Research
- Neurobiology Research
Detailed Description
Mouse embyros homozygous for the Dll1tm1Gos targeted mutation establish a primary metameric pattern in the mesoderm. Cytodifferentiation appears normal, but the segments have no cranio-caudal polarity, and no epithelial somites form. Caudal sclerotome halves do not condense, and the pattern of spinal ganglia and nerves is perturbed, indicating loss of segment polarity. Myoblasts span segment borders, demonstrating that these borders are not maintained.
Development
The replacement vector was constructed by inserting a 4-kilobase ClaI/XhoI fragment, which encodes a part of the beta-galactosidase gene followed by the PGK-neo cassette, and a 2.6-kb XhoI/EcoRI fragment as the 3' homologous region of the replacement vector into pKS+.
Expression Data
| Expressed Gene | lacZ, beta-galactosidase, E. coli |
|---|---|
| Site of Expression |
Control Suggestions
- Wild-type from the colony
- 000664 C57BL/6J
Additional Information
Selected References
- Hrabe de Angelis M; McIntyre J 2nd; Gossler A. 1997. Maintenance of somite borders in mice requires the Delta homologue DII1. Nature 386(6626):717-21. PubMed: 9109488MGI: J:39633
Dll1tm1Gos
Allele Symbol: Dll1tm1Gos
| Allele Name | targeted mutation 1, Achim Gossler |
|---|---|
| Allele Type | Targeted (Null/Knockout, Reporter) |
| Allele Synonym(s) | Dll1-; Dll1lacZ |
| Gene Symbol and Name | Dll1, delta-like 1 (Drosophila) |
| Gene Synonym(s) | DELTA1; DL1; Delta; Delta1 |
| Expressed Gene | lacZ, beta-galactosidase, E. coli |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Chromosome | 17 |
| Molecular Note | In-frame insertion of a LacZ-PGK-neomycin resistance cassette replaced sequences that code for amino acids 2-116 of the Dll1 gene. |
| Mutations Made By | Dr. Achim Gossler, Medizinische Hochschule Hannover |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Dll1tm1Gos related
- Developmental Biology Research
- Embryonic Lethality (Homozygous)
- Internal/Organ Defects
- Neural Tube Defects
- Neurodevelopmental Defects
- Neurobiology Research
- Neural Tube Defects
- Neurodevelopmental Defects
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Dll1tm1Gos/Dll1+
C3Fe.129-Dll1tm1Gos
immune system phenotype
- decreased B-1 B cell number
- in female mice (MGI Ref ID J:150183)
- decreased CD4-positive, alpha beta T cell number
- in female, but not male, mice (MGI Ref ID J:150183)
- decreased CD8-positive, alpha-beta T cell number
- female mice exhibit a decrease in CD8alpha,beta T cells compared with wild-type mice (MGI Ref ID J:150183)
- decreased IgA level
- in female mice (MGI Ref ID J:150183)
- decreased IgG1 level
- in female mice (MGI Ref ID J:150183)
- decreased IgG2b level
- in female mice (MGI Ref ID J:150183)
- decreased IgG3 level
- in female mice (MGI Ref ID J:150183)
- increased B cell number
- in female, but not male, mice (MGI Ref ID J:150183)
- increased CD8-positive, alpha-beta T cell number
- male mice exhibit an increase in CD8alpha,beta T cells compared with wild-type mice (MGI Ref ID J:150183)
homeostasis/metabolism phenotype
- abnormal enzyme/coenzyme activity
- alpha-amylase activity is decreased compared to in wild-type mice (MGI Ref ID J:150183)
- decreased basal metabolism
- mice exhibit reduced metabolized energy compared with wild-type mice (MGI Ref ID J:150183)
- decreased blood uric acid level
- (MGI Ref ID J:150183)
- decreased circulating cholesterol level
- in male mice (MGI Ref ID J:150183)
- decreased circulating total protein level
- (MGI Ref ID J:150183)
- decreased circulating triglyceride level
- (MGI Ref ID J:150183)
- increased basal metabolism
- Background Sensitivity - when normalized to individual body weight, male mice congenic on a C3 background exhibit increased metabolized energy while male mice exhibit only a tendency compared with wild-type mice whereas on a 129 background only female mice exhibit increased metabolized energy compared with wild-type miceolized energy compared with wild-type mice (MGI Ref ID J:150183)
skeleton phenotype
- decreased bone mineral density
- however, bone content related to body weight is normal (MGI Ref ID J:150183)
- whole body bone mineral content is reduced in female mice and tends to be reduced in male mice compared with wild-type mice (MGI Ref ID J:150183)
- whole body bone mineral density is reduced compared to in wild-type mice (MGI Ref ID J:150183)
- decreased lumbar vertebrae number
- in one mouse (MGI Ref ID J:150183)
- increased bone mineral density
growth/size/body region phenotype
- decreased body height
- mice are shorter than wild-type mice (MGI Ref ID J:150183)
- decreased body weight
- decreased lean body mass
- average body lean body mass and the average fat to lean mass ratio are reduced compared to in wild-type mice (MGI Ref ID J:150183)
- increased susceptibility to weight loss
- mice fasted for 2 days exhibit a greater loss of body weight compared with similarly treated wild-type mice (MGI Ref ID J:150183)
cardiovascular system phenotype
- abnormal Q wave
- the Q amplitude is increased compared to in wild-type mice (MGI Ref ID J:150183)
- decreased heart rate
- pulse and heart rate in female mice are decreased compared to in wild-type mice (MGI Ref ID J:150183)
- increased mean systemic arterial blood pressure
- at 14 weeks in male mice (MGI Ref ID J:150183)
- increased systemic arterial diastolic blood pressure
- at 14 weeks in male mice (MGI Ref ID J:150183)
- increased systemic arterial systolic blood pressure
- at 14 weeks in male mice (MGI Ref ID J:150183)
adipose tissue phenotype
- decreased total body fat amount
- average body fat content and the average fat to lean mass ratio are reduced compared to in wild-type mice (MGI Ref ID J:150183)
behavior/neurological phenotype
- decreased food intake
- mice consume less food and have a reduced energy uptake compared with wild-type mice (MGI Ref ID J:150183)
- hypoactivity
- mice exhibit a tendency towards reduced locomotor activity compared with wild-type mice (MGI Ref ID J:150183)
digestive/alimentary phenotype
- abnormal defecation
- mice produce less feces than wild-type mice (MGI Ref ID J:150183)
hematopoietic system phenotype
- decreased B-1 B cell number
- in female mice (MGI Ref ID J:150183)
- decreased CD4-positive, alpha beta T cell number
- in female, but not male, mice (MGI Ref ID J:150183)
- decreased CD8-positive, alpha-beta T cell number
- female mice exhibit a decrease in CD8alpha,beta T cells compared with wild-type mice (MGI Ref ID J:150183)
- decreased IgA level
- in female mice (MGI Ref ID J:150183)
- decreased IgG1 level
- in female mice (MGI Ref ID J:150183)
- decreased IgG2b level
- in female mice (MGI Ref ID J:150183)
- decreased IgG3 level
- in female mice (MGI Ref ID J:150183)
- increased B cell number
- in female, but not male, mice (MGI Ref ID J:150183)
- increased CD8-positive, alpha-beta T cell number
- male mice exhibit an increase in CD8alpha,beta T cells compared with wild-type mice (MGI Ref ID J:150183)
Genotype: Dll1tm1Gos/Dll1+
involves: 129S1/Sv * 129X1/SvJ
immune system phenotype
- decreased CD4-positive, alpha beta T cell number
- a non-significant reduction (MGI Ref ID J:150183)
- increased B cell number
- in female but not male mice (MGI Ref ID J:150183)
homeostasis/metabolism phenotype
- increased basal metabolism
- Background Sensitivity - when normalized to individual body weight, female mice on a 129 background exhibit increased metabolized energy while male mice exhibit only a tendency compared with wild-type mice whereas on a congenic C3 background only male mice exhibit increased metabolized energy compared with wild-type miceolized energy compared with wild-type mice (MGI Ref ID J:150183)
growth/size/body region phenotype
- increased susceptibility to weight loss
- mice fasted for 2 days exhibit a greater loss of body weight compared with similarly treated wild-type mice (MGI Ref ID J:150183)
skeleton phenotype
- abnormal bone mineral density
- similar to on a C3 background, mice exhibit abnormal bone mineral density compared with wild-type mice (MGI Ref ID J:150183)
hematopoietic system phenotype
- decreased CD4-positive, alpha beta T cell number
- a non-significant reduction (MGI Ref ID J:150183)
- increased B cell number
- in female but not male mice (MGI Ref ID J:150183)
Genotype: Dll1tm1Gos/Dll1tm1Gos
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
mortality/aging
- embryonic lethality during organogenesis, complete penetrance
- death around E12 (MGI Ref ID J:39633)
embryo phenotype
- abnormal direction of embryo turning
- tail rotation to the left in about 48% of embryos but random relative to heart looping (MGI Ref ID J:80018)
- abnormal notochord morphology
- abnormal paraxial mesoderm morphology
- severe patterning defects in paraxial mesoderm (MGI Ref ID J:39633)
- abnormal primitive node morphology
- abnormal somite border morphology
- myoblasts span segment (somite) borders, indicating that borders are not maintained (MGI Ref ID J:39633)
- abnormal somite development
- (MGI Ref ID J:39633)
- abnormal somite shape
- absent embryonic cilia
- loss of monociliated cells (MGI Ref ID J:80018)
- enlarged floor plate
- enlarged floor plate between E8.5 and E10.5 (MGI Ref ID J:80018)
- incomplete somite formation
nervous system phenotype
- abnormal brain development
- hyperplastic CNS (MGI Ref ID J:39633)
- abnormal neuron differentiation
- excessive neuronal differentiation in CNS (MGI Ref ID J:39633)
- abnormal somatic nervous system morphology
- (MGI Ref ID J:39633)
- enlarged floor plate
- enlarged floor plate between E8.5 and E10.5 (MGI Ref ID J:80018)
- fused dorsal root ganglion
- (MGI Ref ID J:39633)
cardiovascular system phenotype
- abnormal direction of heart looping
- hemorrhage
- severely hemorrhagic after E10 (MGI Ref ID J:39633)
endocrine/exocrine gland phenotype
- abnormal pancreas development
cellular phenotype
- abnormal neuron differentiation
- excessive neuronal differentiation in CNS (MGI Ref ID J:39633)
- absent embryonic cilia
- loss of monociliated cells (MGI Ref ID J:80018)
Genotype: Dll1tm1Gos/Dll1tm1Gos
involves: 129S1/Sv * 129X1/SvJ
mortality/aging
- embryonic lethality during organogenesis, complete penetrance
- die at E12 (MGI Ref ID J:156172)
nervous system phenotype
- abnormal neuron differentiation
- expression analysis indicates and increase in the pace of neurogenesis (MGI Ref ID J:156172)
- increase in the number of Chx10+ V2a, Gata3+ V2b and Evx1/Evx2+ V0 neurons at E10.5 in the intermediate and ventral neural tube (MGI Ref ID J:156172)
- overproduction of Isl1/Isl2+ motoneurons at E9.5 in the intermediate and ventral neural tube (MGI Ref ID J:156172)
- decreased neuronal precursor cell number
- increased motor neuron number
- overproduction of Isl1/Isl2+ motoneurons at E9.5 in the intermediate and ventral neural tube (MGI Ref ID J:156172)
- increased neuron number
- increase in the number of Chx10+ V2a, Gata3+ V2b and Evx1/Evx2+ V0 neurons at E10.5 in the intermediate and ventral neural tube (MGI Ref ID J:156172)
cellular phenotype
- abnormal neuron differentiation
- expression analysis indicates and increase in the pace of neurogenesis (MGI Ref ID J:156172)
- increase in the number of Chx10+ V2a, Gata3+ V2b and Evx1/Evx2+ V0 neurons at E10.5 in the intermediate and ventral neural tube (MGI Ref ID J:156172)
- overproduction of Isl1/Isl2+ motoneurons at E9.5 in the intermediate and ventral neural tube (MGI Ref ID J:156172)
References
- Hrabe de Angelis M; McIntyre J 2nd; Gossler A. 1997. Maintenance of somite borders in mice requires the Delta homologue DII1. Nature 386(6626):717-21. PubMed: 9109488MGI: J:39633
Additional References
- Kume T; Jiang H; Topczewska JM; Hogan BL. 2001. The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev 15(18):2470-82. PubMed: 11562355MGI: J:71693
- Zhang N; Norton CR; Gridley T. 2002. Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice. Genesis 33(1):21-8. PubMed: 12001066MGI: J:77247
Additional - Dll1tm1Gos related
- Ahnfelt-Ronne J; Jorgensen MC; Klinck R; Jensen JN; Fuchtbauer EM; Deering T; Macdonald RJ; Wright CV; Madsen OD; Serup P. 2012. Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. Development 139(1):33-45. PubMed: 22096075MGI: J:178999
- Apelqvist A; Li H; Sommer L; Beatus P; Anderson DJ; Honjo T; Hrabe de Angelis M; Lendahl U; Edlund H. 1999. Notch signalling controls pancreatic cell differentiation. Nature 400(6747):877-81. PubMed: 10476967MGI: J:57072
- Barrantes IB; Elia AJ; Wunsch K; De Angelis MH; Mak TW; Rossant J; Conlon RA; Gossler A; de la Pompa JL. 1999. Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol 9(9):470-80. PubMed: 10330372MGI: J:54606
- Brohl D; Vasyutina E; Czajkowski MT; Griger J; Rassek C; Rahn HP; Purfurst B; Wende H; Birchmeier C. 2012. Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals. Dev Cell 23(3):469-81. PubMed: 22940113MGI: J:188916
- Chen J; Kang L; Zhang N. 2005. Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis. Genesis 43(4):196-204. PubMed: 16342160MGI: J:104451
- Cheng HT; Kim M; Valerius MT; Surendran K; Schuster-Gossler K; Gossler A; McMahon AP; Kopan R. 2007. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 134(4):801-11. PubMed: 17229764MGI: J:119907
- Cordes R; Schuster-Gossler K; Serth K; Gossler A. 2004. Specification of vertebral identity is coupled to Notch signalling and the segmentation clock. Development 131(6):1221-33. PubMed: 14960495MGI: J:88580
- Czajkowski MT; Rassek C; Lenhard DC; Brohl D; Birchmeier C. 2014. Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle. Dev Biol 395(2):307-16. PubMed: 25220152MGI: J:216287
- De Bellard M; Ching W; Gossler A; Bronner-Fraser M. 2002. Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice. Dev Biol 249(1):121. PubMed: 12217323MGI: J:78768
- Estrach S; Cordes R; Hozumi K; Gossler A; Watt FM. 2008. Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis. J Invest Dermatol 128(4):825-32. PubMed: 17960184MGI: J:135515
- Feyerabend TB; Terszowski G; Tietz A; Blum C; Luche H; Gossler A; Gale NW; Radtke F; Fehling HJ; Rodewald HR. 2009. Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms. Immunity 30(1):67-79. PubMed: 19110448MGI: J:143731
- Geffers I; Serth K; Chapman G; Jaekel R; Schuster-Gossler K; Cordes R; Sparrow DB; Kremmer E; Dunwoodie SL; Klein T; Gossler A. 2007. Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo. J Cell Biol 178(3):465-76. PubMed: 17664336MGI: J:234164
- Hatakeyama J; Wakamatsu Y; Nagafuchi A; Kageyama R; Shigemoto R; Shimamura K. 2014. Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. Development 141(8):1671-82. PubMed: 24715457MGI: J:208850
- Huppert SS; Ilagan MX; De Strooper B; Kopan R. 2005. Analysis of Notch Function in Presomitic Mesoderm Suggests a gamma-Secretase-Independent Role for Presenilins in Somite Differentiation. Dev Cell 8(5):677-88. PubMed: 15866159MGI: J:98438
- Jouve C; Palmeirim I; Henrique D; Beckers J; Gossler A; Ish-Horowicz D; Pourquie O. 2000. Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm. Development 127(7):1421-9. PubMed: 10704388MGI: J:60836
- Kiernan AE; Cordes R; Kopan R; Gossler A; Gridley T. 2005. The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development 132(19):4353-62. PubMed: 16141228MGI: J:132241
- Koch U; Fiorini E; Benedito R; Besseyrias V; Schuster-Gossler K; Pierres M; Manley NR; Duarte A; Macdonald HR; Radtke F. 2008. Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med 205(11):2515-23. PubMed: 18824585MGI: J:143472
- Krebs LT; Iwai N; Nonaka S; Welsh IC; Lan Y; Jiang R; Saijoh Y; O'Brien TP; Hamada H; Gridley T. 2003. Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev 17(10):1207-12. PubMed: 12730124MGI: J:83358
- Leimeister C; Dale K; Fischer A; Klamt B; Hrabe de Angelis M; Radtke F; McGrew MJ; Pourquie O; Gessler M. 2000. Oscillating expression of c-hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors Dev Biol 227(1):91-103. PubMed: 11076679MGI: J:65682
- Leimeister C; Schumacher N; Steidl C; Gessler M. 2000. Analysis of HeyL expression in wild-type and notch pathway mutant mouse embryos Mech Dev 98(1-2):175-8. PubMed: 11044625MGI: J:65645
- Limbourg A; Ploom M; Elligsen D; Sorensen I; Ziegelhoeffer T; Gossler A; Drexler H; Limbourg FP. 2007. Notch ligand Delta-like 1 is essential for postnatal arteriogenesis. Circ Res 100(3):363-71. PubMed: 17234965MGI: J:133690
- Liu Z; Brunskill E; Boyle S; Chen S; Turkoz M; Guo Y; Grant R; Kopan R. 2015. Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development 142(6):1193-202. PubMed: 25725069MGI: J:220445
- Machka C; Kersten M; Zobawa M; Harder A; Horsch M; Halder T; Lottspeich F; Hrabe de Angelis M; Beckers J. 2005. Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling. Gene Expr Patterns 6(1):94-101. PubMed: 15979417MGI: J:103128
- Marklund U; Hansson EM; Sundstrom E; de Angelis MH; Przemeck GK; Lendahl U; Muhr J; Ericson J. 2010. Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development 137(3):437-45. PubMed: 20081190MGI: J:156172
- McCright B; Gao X; Shen L; Lozier J; Lan Y; Maguire M; Herzlinger D; Weinmaster G; Jiang R; Gridley T. 2001. Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development 128(4):491-502. PubMed: 11171333MGI: J:67157
- Mielcarek M; Piotrowska I; Schneider A; Gunther S; Braun T. 2009. VITO-2, a new SID domain protein, is expressed in the myogenic lineage during early mouse embryonic development. Gene Expr Patterns 9(3):129-37. PubMed: 19118645MGI: J:144198
- Morrison A; Hodgetts C; Gossler A; Hrabe de Angelis M; Lewis J. 1999. Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear. Mech Dev 84(1-2):169-72. PubMed: 10473135MGI: J:56415
- Napp LC; Augustynik M; Paesler F; Krishnasamy K; Woiterski J; Limbourg A; Bauersachs J; Drexler H; Le Noble F; Limbourg FP. 2012. Extrinsic Notch ligand Delta-like 1 regulates tip cell selection and vascular branching morphogenesis. Circ Res 110(4):530-5. PubMed: 22282195MGI: J:192694
- Obata Y; Kimura S; Nakato G; Iizuka K; Miyagawa Y; Nakamura Y; Furusawa Y; Sugiyama M; Suzuki K; Ebisawa M; Fujimura Y; Yoshida H; Iwanaga T; Hase K; Ohno H. 2014. Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues. EMBO Rep 15(12):1297-304. PubMed: 25378482MGI: J:217542
- Okubo Y; Sugawara T; Abe-Koduka N; Kanno J; Kimura A; Saga Y. 2012. Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling. Nat Commun 3:1141. PubMed: 23072809MGI: J:205623
- Pfister S; Przemeck GK; Gerber JK; Beckers J; Adamski J; Hrabe de Angelis M. 2003. Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1. J Mol Biol 333(2):229-35. PubMed: 14529612MGI: J:114126
- Przemeck GK; Heinzmann U; Beckers J; Hrabe De Angelis M. 2003. Node and midline defects are associated with left-right development in Delta1 mutant embryos. Development 130(1):3-13. PubMed: 12441287MGI: J:80018
- Raya A; Kawakami Y; Rodriguez-Esteban C; Buscher D; Koth CM; Itoh T; Morita M; Raya RM; Dubova I; Bessa JG; de la Pompa JL; Belmonte JC. 2003. Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev 17(10):1213-8. PubMed: 12730123MGI: J:83387
- Rocha SF; Lopes SS; Gossler A; Henrique D. 2009. Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity. Dev Biol 328(1):54-65. PubMed: 19389377MGI: J:149456
- Rubio-Aliaga I; Przemeck GK; Fuchs H; Gailus-Durner V; Adler T; Hans W; Horsch M; Rathkolb B; Rozman J; Schrewe A; Wagner S; Hoelter SM; Becker L; Klopstock T; Wurst W; Wolf E; Klingenspor M; Ivandic BT; Busch DH; Beckers J; Hrabe de Angelis M. 2009. Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. PLoS One 4(6):e6054. PubMed: 19562077MGI: J:150183
- Rubio-Aliaga I; Soewarto D; Wagner S; Klaften M; Fuchs H; Kalaydjiev S; Busch DH; Klempt M; Rathkolb B; Wolf E; Abe K; Zeiser S; Przemeck GK; Beckers J; de Angelis MH. 2007. A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. Genetics 175(3):1451-63. PubMed: 17179084MGI: J:119997
- Schuster-Gossler K; Cordes R; Gossler A. 2007. Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci U S A 104(2):537-42. PubMed: 17194759MGI: J:119082
- Schwarting GA; Gridley T; Henion TR. 2007. Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium. J Mol Histol 38(6):543-53. PubMed: 17605079MGI: J:130594
- Sorensen I; Adams RH; Gossler A. 2009. DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood 113(22):5680-8. PubMed: 19144989MGI: J:148902
- Stamataki D; Holder M; Hodgetts C; Jeffery R; Nye E; Spencer-Dene B; Winton DJ; Lewis J. 2011. Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system. PLoS One 6(9):e24484. PubMed: 21915337MGI: J:177887
- Takahashi Y; Yasuhiko Y; Kitajima S; Kanno J; Saga Y. 2007. Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation. Dev Biol 304(2):593-603. PubMed: 17306789MGI: J:122532
- Tan JB ; Xu K ; Cretegny K ; Visan I ; Yuan JS ; Egan SE ; Guidos CJ. 2009. Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Immunity 30(2):254-63. PubMed: 19217325MGI: J:146621
- Trujillo-Paredes N; Valencia C; Guerrero-Flores G; Arzate DM; Baizabal JM; Guerra-Crespo M; Fuentes-Hernandez A; Zea-Armenta I; Covarrubias L. 2016. Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain. Biol Open 5(3):336-47. PubMed: 26912775MGI: J:231516
- Xu K; Usary J; Kousis PC; Prat A; Wang DY; Adams JR; Wang W; Loch AJ; Deng T; Zhao W; Cardiff RD; Yoon K; Gaiano N; Ling V; Beyene J; Zacksenhaus E; Gridley T; Leong WL; Guidos CJ; Perou CM; Egan SE. 2012. Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer. Cancer Cell 21(5):626-41. PubMed: 22624713MGI: J:189299
- Yun K; Fischman S; Johnson J; De Angelis MH; Weinmaster G; Rubenstein JL. 2002. Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon. Development 129(21):5029-40. PubMed: 12397111MGI: J:79854
- Zhang N; Norton CR; Gridley T. 2002. Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice. Genesis 33(1):21-8. PubMed: 12001066MGI: J:77247