JAX Mouse Strain Datasheet - 002919

STOCK Myo7a^sh1-7J/J

Stock No:: 002919 |; shaker 1, 7 Jackson

Chemically Induced Mutation

Cryo Recovery

Overview

Also Known As: shaker 1, 7 Jackson

These mice carry an ENU-induced mutation characterized by circling behavior, head tilt and bob, and deafness.

Genetic overview

Genetic Background	Generation

Myo7a^sh1-7J

Allele Type	Gene Symbol	Gene Name
Chemically induced (ENU)	Myo7a	myosin VIIA

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Research Applications

Neurobiology Research
Sensorineural Research

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

Myo7a^sh1-7J homozygotes exhibit circling behavior, a slight head tilt and side-to-side head bob. They develop progressive hearing loss, becoming totally deaf by 60 days of age. Heterozygotes are normal. (Samples et al., 2000). Mutations of the human ortholog of Myo7a, MYO7A, have been characterized in pedigrees of patients having Usher syndrome type 1 (USH1), an autosomal recessive disorder characterized by profound deafness, vestibular dysfunction and progressive retinitis pigmentosa (Weil et al., 1995; Weston et al., 1996; Adato et al., 1997; Levy et al., 1997; Liu et al., 1998; Espinos et al., 1998; Cuevas et al., 1998, 1999; Janecke et al., 1999). MYO7A mutations have also been identified in patients with autosomal dominant non-syndromic deafness (Liu et al., 1997) and autosomal recessive isolated deafness (Liu et al., 1997; Weil et al., 1997).

Development

A male B10.D2-H2^dm1/Eg treated with 30 mg of 1-ethyl-1-nitrosourea (ENU) was bred with a female C57BL/6J-H2^bm3/Eg and the offspring were sibling mated. A circling phenotype was identified in subsequent progeny that were homozygous for the H2^bm3 allele. This mutation was shown to be an allele of Myo7a and was backcrossed once to C57BL/6J before being subsequently maintained by sibling mating.

Control Suggestions

Untyped from the colony

Additional Information

Considerations for Choosing Controls

Genetics

Myo7a^sh1-7J

Allele Symbol: Myo7a^sh1-7J

Allele Name	shaker 1, 7 Jackson
Allele Type	Chemically induced (ENU)
Allele Synonym(s)
Gene Symbol and Name	Myo7a, myosin VIIA
Gene Synonym(s)	DFNA11; DFNB2; Hdb; Hdb; MYOVIIA; MYU7A; Myo7; Myo7; NSRD2; USH1B; headbanger; myosin VII; neuroscience mutagenesis facility, 371; nmf371; nmf371; polka; polka; polka; sh-1; sh1; shaker 1
Strain of Origin	B10.D2-H2/Eg
Chromosome	7
Molecular Note	Failure to complement with the original shaker 1 mutation proved that this mutation is an allele of Myo7a.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Myo7a^sh1-7J related

Neurobiology Research
- Hearing Defects
- Tremor Defects
- Vestibular Defects
Sensorineural Research
- Hearing Defects
- Vestibular Defects

Mammalian Phenotype Terms by Genotype

Genotype: Myo7a^sh1-7J/Myo7a^sh1-7J
STOCK Myo7a^sh1-7J/J

behavior/neurological phenotype

circling

head shaking
- described as a side-to-side head bob

head tilt
- described as a slight head tilt

hearing/vestibular/ear phenotype

deafness
- progressive hearing loss was noted; homozygotes are totally deaf by 60 days of age

References

Additional References

Gibson F; Walsh J; Mburu P; Varela A; Brown KA; Antonio M; Beisel KW; Steel KP; Brown SD. 1995. A type VII myosin encoded by the mouse deafness gene shaker-1. Nature 374(6517):62-4. PubMed: 7870172 MGI: J:23257
Weil D; Blanchard S; Kaplan J; Guilford P; Gibson F; Walsh J; Mburu P; Varela A; Levilliers J; Weston MD; Kelley PM; Kimberling WJ; Wagenaar M; Levi-Acobas F; Larget-Piet D; Munnich A; Steel KP; Brown SDM; Petit C. 1995. Defective myosin VIIA gene responsible for Usher syndrome type 1B. Nature 374(6517):60-1. PubMed: 7870171 MGI: J:23239
Weil D; Kussel P; Blanchard S; Levy G; Levi-Acobas F; Drira M ; Ayadi H ; Petit C. 1997. The autosomal recessive isolated deafness, DFNB2, and the Usher 1B syndrome are allelic defects of the myosin-VIIA gene. Nat Genet 16(2):191-3. PubMed: 9171833 MGI: J:40770

Additional - Myo7a^sh1-7J related

Cook SA; Zheng QY; Samples RM; Davisson MT. 2004. A new allele, sh1-7J, of the Myo7a gene MGI Direct Data Submission :. MGI: J:91063
Zheng QY; Scarborough JD; Zheng Y; Yu H; Choi D; Gillespie PG. 2012. Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes. Hum Mol Genet 21(11):2588-98. PubMed: 22381527 MGI: J:183898
Zou J; Chen Q; Almishaal A; Mathur PD; Zheng T; Tian C; Zheng QY; Yang J. 2017. The roles of USH1 proteins and PDZ domain-containing USH proteins in USH2 complex integrity in cochlear hair cells. Hum Mol Genet 26(3):624-636. PubMed: 28031293 MGI: J:241430

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service	Genotype	Price
	Heterozygous or Homozygous for Myo7a<sh1-7J>

Progeny testing is not required

The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks.

The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

Terms of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As: shaker 1, 7 Jackson

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

Myo7ash1-7J

Allele Symbol: Myo7ash1-7J

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Myo7ash1-7J related

Mammalian Phenotype Terms by Genotype

Genotype: Myo7ash1-7J/Myo7ash1-7JSTOCK Myo7ash1-7J/J

behavior/neurological phenotype

hearing/vestibular/ear phenotype

References

Additional References

Additional - Myo7ash1-7J related

Genotyping Protocols

Appearance

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Progeny testing is not required

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Myo7a^sh1-7J

Allele Symbol: Myo7a^sh1-7J

Genotype: Myo7a^sh1-7J related

Genotype: Myo7a^sh1-7J/Myo7a^sh1-7J
STOCK Myo7a^sh1-7J/J

Additional - Myo7a^sh1-7J related