The deaf waddler 2J allele (Atp2b2dfw-2J) arose spontaneously in a congenic substrain of BALB/cByJ mice, CByJ.A-fsn/J. Homozygous mutant mice are viable, but neither sex will breed. They are recognizable by 12-14 days of age by their hesitant, wobbly gait and head bobbing behavior. Homozygotes also develop a slight body tremor and become increasingly lethargic. Homozygous mutant mice are profoundly deaf, exhibiting no discernible auditory brainstem responses (ABR) to stimuli up to 100 dB. Heterozygous Atp2b2dfw-2J mutant mice also show age-dependent changes in ABR and progressive hearing loss as a result of a modifier allele (ahl) present in BALB/cByJ mice.
|Allele Name||deaf waddler 2 Jackson|
|Gene Symbol and Name||Atp2b2, ATPase, Ca++ transporting, plasma membrane 2|
|Strain of Origin||CByJ.A-Ttc7fsn/J|
|Molecular Note||A 2 bp nucleotide deletion at positions 1368 and 1369 cause a frameshift that results in a premature stop and truncation of the encoded protein at position 471.|
When using the deaf waddler 2 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #002894 in your Materials and Methods section.