This colony is currently unavailable and we are unable to determine when it will be available in the future.
These mice are characterized by a heightened agouti yellow pigment in coat color and have an increased number of Ig C lambda genes.
This strain has a coat color mutation which results in heightened agouti yellow pigment. The number of Ig C lambda genes in this strain has been estimated to be 12 in contrast to inbred strains, all of which have been examined have only four C lambda genes. This mutation has not yet been characterized in detail.
In 2019-2020, researchers at The Jackson Laboratory discovered this inbred strain contains the Trem2S148E allele - a naturally occurring variant at position 48351151-48351152 on Chr 17 (rs108080490 and rs107649577; Ensembl GRCm38.p6). This TC to GA transition results in a serine to glutamic acid substitution at amino acid 148 (S148E).
Progenitors of the CZECHI/Ei strain were originally trapped in Studenec, Morovia in 1978 by Dr Richard Sage who gave mice to Dr Mike Potter at The National Cancer Institute who subsequently transferred mice ranging between F32 and F36 to Dr Eva Eicher at The Jackson Laboratory in 1996 from which time they have continued to be sibling inbred.
Currently there are no related genes or alleles for this strain.