Mice that are homozygous for the poly(ADP-ribose) polymerase-1 null mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Although a shortened transcript is generated, no enzymatic activity is detected in tissues. Proliferation of homozygous fibroblasts and thymocytes is impaired following gamma-radiation in comparison to cells derived from wildtype mice. Older mice are susceptible to spontaneous development of skin disease. A significant portion of older mice (~30%) can be expected to exhibit epidermal hyperplasia. Null mice are also less susceptible to damage induced by the neurotoxin MPTP.

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 Poly(ADP-ribose) polymerase-1 knock-out mice may be useful in studying DNA repair, programmed cell death, aging, differentiation, proliferation and tumor transformation.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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