C3Fe.Cg-scb/J

Stock number: 002758
Product name: scabby
Research areas: Dermatology Research, Developmental Biology Research

Description

The Scabby mutation is characterized by an abnormal skin condition, localized abnormal hair growth and a short, kinky, tail.

Detailed description

Scabby is a recessive mutation that maps to chromosome 8. Homozygotes display scar tissue on the skin and tail shortly after birth with defects in hair growth in these areas. Transverse stripes particularly over the rump may be seen in the juvenile coat, but are generally absent in the adult. Webbed feet and a short and kinky or constricted tail may also be seen. Homozygotes are viable and fertile although males breed better than females. (Searle and Beechey, 1977.)

Development

The scb mutation arose spontaneously at Harwell in 1976 on the C3H/HeH background. The line was maintained primarily through sibling matings of homozygotes with occasional outcrossing to (C3H/HeH x 101H)F1. In 1987 homozygous males of the 17th generation were bred with (C3H/HeH x 101H)F1 females to generate embryos for cryopreservation. In 1995 some of these heterozygous embryos were transferred from Harwell to The Jackson Laboratory where they were thawed, reared, and sibling bred. This mutation was then moved onto the C3HeB/FeJ background via backcross-intercross breeding and in 2003 this strain reached NE7. It was then maintained by sibling breeding heterozygotes with homozygotes, with a preference for the homozygote to be a male since they are better breeders than homozygous females. In 2005 this strain was cryopreserved at The Jackson Laboratory using C3HeB/FeJ females and homozygous males at N7F5.

Allele

Symbol: scb
Name: scabby
MGI accession ID: MGI:1857030
Generation method: Spontaneous
Marker symbol: scb
Marker name: scabby
Chromosome: 8
Strain of origin: C3H/HeH