Scabby is a recessive mutation that maps to chromosome 8. Homozygotes display scar tissue on the skin and tail shortly after birth with defects in hair growth in these areas. Transverse stripes particularly over the rump may be seen in the juvenile coat, but are generally absent in the adult. Webbed feet and a short and kinky or constricted tail may also be seen. Homozygotes are viable and fertile although males breed better than females. (Searle and Beechey, 1977.)

Development

The scb mutation arose spontaneously at Harwell in 1976 on the C3H/HeH background. The line was maintained primarily through sibling matings of homozygotes with occasional outcrossing to (C3H/HeH x 101H)F1. In 1987 homozygous males of the 17th generation were bred with (C3H/HeH x 101H)F1 females to generate embryos for cryopreservation. In 1995 some of these heterozygous embryos were transferred from Harwell to The Jackson Laboratory where they were thawed, reared, and sibling bred. This mutation was then moved onto the C3HeB/FeJ background via backcross-intercross breeding and in 2003 this strain reached NE7. It was then maintained by sibling breeding heterozygotes with homozygotes, with a preference for the homozygote to be a male since they are better breeders than homozygous females. In 2005 this strain was cryopreserved at The Jackson Laboratory using C3HeB/FeJ females and homozygous males at N7F5.

Control Suggestions

Heterozygote from the colony

Additional Information

Considerations for Choosing Controls

Genetics

scb

Allele Symbol: scb

Allele Name	scabby
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	scb, scabby
Gene Synonym(s)
Strain of Origin	C3H/HeH
Chromosome	8

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: scb related

Dermatology Research
- Skin and Hair Texture Defects
Developmental Biology Research
- Skeletal Defects
- Skin and Hair Texture Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: scb/scb
C3H/HeH-scb

cellular phenotype

abnormal chromosome morphology

elevated level of mitotic sister chromatid exchange
- observation made using primary embryonic cell cultures

limbs/digits/tail phenotype

abnormal tail morphology

kinked tail

short tail
- may have constrictions

mammalian phenotype

skeleton phenotype

integument phenotype

abnormal coat appearance
- adult coat may appear normal
- dark transverse stripes appear in the juvenile (agouti) coat forming from the damaged skin areas but disappear after subsequent hair cycles

abnormal coat/ hair morphology

abnormal hair growth
- dark transverse stripes appear in the juvenile coat forming from the damaged skin areas but disappear after subsequent hair cycles
- occurs in scabby areas on the body

abnormal skin condition

scaly skin
- displays as transverse areas of scar tissue especially in the lumbar region with similar regions on the legs and tail
- observed shortly after birth

References

Additional - scb related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Appearance
- skin and tail defects
  Related Genotype: scb/scb
  
  unaffected
  Related Genotype: scb/+
Citation
When using the scabby mouse strain in a publication, please cite the originating article(s) and include JAX stock #002758 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Heterozygous for scb

Related Products and Services

Frozen Mouse Embryo	C3Fe.Cg-scb/J Frozen Embryos	$2595.00
Frozen Mouse Embryo	C3Fe.Cg-scb/J Frozen Embryos	$2595.00
Frozen Mouse Embryo	C3Fe.Cg-scb/J Frozen Embryos	$3373.50
Frozen Mouse Embryo	C3Fe.Cg-scb/J Frozen Embryos	$3373.50

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

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Also Known As:scabby

Genetic overview

Research Applications

Base Price

Detailed Description