Homozygous mice die at about embryonic day 12-13. They have a hypocellular fetal liver which also displays extensive cell death. They also appear to have a defect in both the hematopoietic cells and their microenvironment.
This strain was developed in the laboratory of Dr. Tyler Jacks at MIT. The targeting vector disrupts exon 1 of the Kras2 gene. This strain was generated on a 129/Sv genetic background. It is currently on an inbred 129/Sv background.
|Allele Name||targeted mutation 1, Tyler Jacks|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||K-ras-; K-rasKO; K-rastm1|
|Gene Symbol and Name||Kras, Kirsten rat sarcoma viral oncogene homolog|
|Strain of Origin||129S2/SvPas|
|Molecular Note||Exon 1 was replaced by a neomycin cassette.|
|Mutations Made By|| |
Dr. Tyler Jacks, Massachusetts Institute of Technology
When maintaining a live colony, heterozygous mice may be bred together.
When using the K-ras- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002674 in your Materials and Methods section.