Mice homozygous for the En1tm1Alj targeted mutation die shortly after birth. They are missing the third and fourth cranial nerves as well as most of the colliculi and cerebellum. The brain phenotype can be less severe depending on the genetic background. There is also a disruption of the dorsal/ventral patterning of the limb paws, a disrupted sterum, and truncation of the 13th ribs. Deletion of mid-hindbrain tissue may be seen as early as embryonic day 9.5.

These En1 knock-out mice exhibit neonatal mortality with multiple developmental defects of the brain and other tissues.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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