B6.Cg-Hmga2^pg-Tg40BCha/BmJ

Stock number: 002644
Product name: mini-mouse
Research areas: Endocrine Deficiency Research

Description

These mice carry a transgenic insertional mutation at the Pg locus characterized by small size.

Detailed description

A human globin gene transgene caused an insertional mutation in the pygmy locus, which has been identified as the high mobility group protein I, isoform C gene. The phenotype is a "mini-mouse", where homozygous transgenics are about 40 percent of the size of wild-type littermates as adults, and heterozygotes are about 80 percent as large as wild-types. Homozygotes are recognizably smaller at birth. Organ sizes were reduced proportionately to the body size reduction, except that the brain was proportionately larger, the adrenals smaller, and less adipose tissue was produced. Homozygotes are viable but infertile.

Allele

Symbol: Hmga2^pg-Tg40BCha
Name: isoform C transgenic, nonhomologous insert 40B, Kiran Chada
MGI accession ID: MGI:1858043
Generation method: Transgenic
Marker symbol: Hmga2
Marker name: high mobility group AT-hook 2
Chromosome: 10
Strain of origin: (CBA/J x C57BL/6J)F2
Molecular note: Insertion of a human globin gene transgene caused this mutation shown to be allelic to Hmga2.