The inbred strain A/HeJ has an increased rate of hermaphrodism and this Y consomic also has an increased rate of hermaphrodism, with some XY embryos developing ovotestes and the population displaying sex ratio distortion, proving that the phenotype segregates with the YA/HeJ Chromosome. At mitotic metaphase some of the YA/HeJ chromatids were found to have a pronounced space between the sister centromeres. However, only a very modest increase in Y chromosome nondisjunction was found, making the mechanism for this model of hermaphrodism different from that caused by the BALB/cWt Y Chromosome (Hunt et al., 2008). This strain provides a model in which to test the propensity of a given allele to tip the developmental scale of sex reversal. When these C57BL/6JEI XYA/HeJ mice are also heterozygous for Zfpm2tm1Sho all develop ovaries, and when they are heterozygous for Gata4tm1Sho they develop ovaries and ovotestes (Bouma et al., 2007).
This consomic strain bearing the Y Chromosome from A/HeJ on the C57BL/6JEi background was generated by crossing an A/HeJ male to a C57BL/6JEi female and repeatedly backcrossing a male offspring to a C57BL/6JEi female. In 1996 embryos were generated for cryopreservation from C57BL/6JEi females bred to consomic C57BL/6JEi-Chr YA/HeJ/Ei males at generation N21.
Currently there are no related genes or alleles for this strain.