Underwhite dense arose as a spontaneous mutation in the TF/Le inbred strain in 1992 and is carried as congenic in this strain with a C57BL/6J genetic background. The ventrum of mutants appear slightly lighter than the dorsum. Eyes are light at birth, but darken with age. The adult eye is deep, dark ruby, although it may appear black to an untrained observer. The similarity to ruby eye (Hps6ru), ruby eye 2 (Hps5ru2 ), and brown (Tyrp1b ) suggests that the underwhite gene may have effects on the shape and color of pigment granules similar to those produced by the ruby eye or brown mutations.
|Allele Name||underwhite dense|
|Gene Symbol and Name||Slc45a2, solute carrier family 45, member 2|
|Strain of Origin||TF/Le|
|Molecular Note||Molecular analysis reveals a T-to-C transition in codon 435, resulting in a serine to proline substitution (p.S435P) within transmembrane domain 10 of the protein.|
When using the underwhite dense mouse strain in a publication, please cite the originating article(s) and include JAX stock #002550 in your Materials and Methods section.