These mice carry the spontaneous Slc45a2uw-d mutation and are characterized by a reduction of pigmentation in both eye and coat color.
Read More +Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Slc45a2 | solute carrier family 45, member 2 |
Underwhite dense arose as a spontaneous mutation in the TF/Le inbred strain in 1992 and is carried as congenic in this strain with a C57BL/6J genetic background. The ventrum of mutants appear slightly lighter than the dorsum. Eyes are light at birth, but darken with age. The adult eye is deep, dark ruby, although it may appear black to an untrained observer. The similarity to ruby eye (Hps6ru), ruby eye 2 (Hps5ru2 ), and brown (Tyrp1b ) suggests that the underwhite gene may have effects on the shape and color of pigment granules similar to those produced by the ruby eye or brown mutations.
Allele Name | underwhite dense |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Slc45a2, solute carrier family 45, member 2 |
Gene Synonym(s) | |
Strain of Origin | TF/Le |
Chromosome | 15 |
Molecular Note | Molecular analysis reveals a T-to-C transition in codon 435, resulting in a serine to proline substitution (p.S435P) within transmembrane domain 10 of the protein. |
When using the underwhite dense mouse strain in a publication, please cite the originating article(s) and include JAX stock #002550 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Slc45a2<uw-d> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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