Homozygotes are viable and fertile. They exhibit an absence of alpha2-mediated peripheral vasoconstriction.
Dr. Brian Kobilka, Stanford University
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Null/Knockout) | Adra2b | adrenergic receptor, alpha 2b |
Homozygotes are viable and fertile. They exhibit an absence of alpha2-mediated peripheral vasoconstriction.
This strain is maintained by mating homozygotes.
Allele Name | targeted mutation 1, Gregory S Barsh |
---|---|
Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | alpha2B-; alpha2B-KO |
Gene Symbol and Name | Adra2b, adrenergic receptor, alpha 2b |
Gene Synonym(s) | |
Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl+ |
Chromosome | 2 |
Molecular Note | A neomycin selection cassette was inserted into the coding sequences, placing a premature stop codon before the sequences encoding the fifth transmembrane domain. Western blot analysis on kidney membrane extracts confirmed that the protein was not detectable in homozygous mice. |
Mutations Made By | Dr. Brian Kobilka, Stanford University |
This strain can be maintained by mating homozygotes.
When using the Adra2b KO mouse strain in a publication, please cite the originating article(s) and include JAX stock #002511 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for Adra2b<tm1Gsb> |
Frozen Mouse Embryo | B6;129-Adra2b<tm1Gsb>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6;129-Adra2b<tm1Gsb>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6;129-Adra2b<tm1Gsb>/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6;129-Adra2b<tm1Gsb>/J Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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