These mice carry an autosomal recessive spontaneous mutation that produces deficiencies in central nervous system myelin, and quaking or trembling of the hindquarters during locomotion.
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Mbp | myelin basic protein |
These mice carry an autosomal recessive spontaneous mutation that produces deficiencies in central nervous system myelin, and quaking or trembling of the hindquarters during locomotion.
Allele Name | myelin deficient |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Mbp, myelin basic protein |
Gene Synonym(s) | |
Strain of Origin | MDB/Dt |
Chromosome | 18 |
General Note | The Mbpshi-mld mutation arose spontaneously in the MDB/Dt strain at Purdue University (J:5917). Two stocks of Mbpshi-mld-bearing mice, both derived from the Purdue original stock at about the same time, and maintained respectively in Worcester, Massachusetts, and in Lausanne, Switzerland, show quantitative differences in life span, in incidence of convulsions, in MBP at older ages, and in proportion of optic axons myelinated. The differences are attributed to differences in regulatory genes in the two stocks, maintained on quite different backgrounds (J:27485).The effects of the Mbpshi-mld mutation are less severe than those of Mbpshi. MBP is present in the CNS, though low in quantity, and the myelin deficient phenotype is rendered normal by an Mbp transgene (J:6320). Mbpshi/Mbpshi-mld heterozygotes are deficient in CNS myelin to a greater extent than Mbpshi-mld/Mbpshi-mld homozygotes, but less than Mbpshi/Mbpshi homozygotes (J:27481). Mbpshi-mld mice have normal lipid/protein ratios, lipid distribution patterns, and only moderate abnormalities of fatty acid profiles (J:27484), whereas these elements are strongly abnormal in Mbpshi (J:6012). Mbpshi caused more severe deficits in learning performance than Mbpshi-mld, while neither affected natural behavior (J:27482). |
Molecular Note | This mutation comprises a tandem duplication and inversion of Mbp. Recombination points indicate that the duplication and inversion event was the result of nonhomologous recombination. Antisense RNA produced by the duplicated gene complexes with sense RNA reducing Mpb expression. |
While maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice (Stock No. 000664). Homozygous mice die before 2 months of age. These mice are extremely sensitive to noise.
When using the myelin deficient mouse strain in a publication, please cite the originating article(s) and include JAX stock #002492 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Mbp<shi-mld> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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