These Ttr knock-out mice exhibit reduced levels of serum retinol, retinol-binding protein and thyroid hormone. They are suitable for use in applications related to the study of vitamin A metabolism and thyroid hormone transport in mammals.
Dr. William S. Blaner, Columbia University
Mice carrying the Ttrtm1Wsb targeted mutation are phenotypically normal, viable and fertile. They have markedly reduced levels of serum retinol, retinol-binding protein and thyroid hormone. The homozygotes can utilize stored retinol despite a defective plasma retinol transport system.
|Allele Name||targeted mutation 1, William S Blaner|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||TTR KO; ttr-|
|Gene Symbol and Name||Ttr, transthyretin|
|Strain of Origin||129S/SvEv-Gpi1c|
|Molecular Note||Insertion of a neomycin resistance cassette into the second exon disrupted the gene. Western blot analysis of peripheral blood using a rat polyclonal antiserum did not detect protein in homozygous mutant mice.|
|Mutations Made By|| |
Dr. William Blaner, Columbia University
When maintaining a live colony, homozygous mice may be bred together.
When using the TTR KO mouse strain in a publication, please cite the originating article(s) and include JAX stock #002382 in your Materials and Methods section.