JAX
Mouse Strain Datasheet - 002374
FVB/N-Tg(MMTV-PyVT)634Mul/J
Also Known As: MMTV-PyMT
Hemizygous MMTV-PyMT females develop palpable mammary tumors which metastasize to the lung. These mice have high penetrance and early onset of mammary cancer compared to other mammary tumor models. Male carriers also develop mammary tumors with a later age of onset. MMTV-PyVT transgenic mice express the Polyoma Virus middle T antigen under the direction of the mouse mammary tumor virus promoter/enhancer.
Donating Investigator
Dr. William Muller, McGill University
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N18+N1F2
(29-DEC-14) |
Tg(MMTV-PyVT)634Mul
| Allele Type |
|---|
| Transgenic (Inserted expressed sequence) |
Base Price
Starting at:
| $246.50 Domestic price for female |
| $320.50 Domestic price for breeder pair |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cancer Research
- Increased Tumor Incidence
- Gonadal Tumors
- Mammary Gland Tumors
- Other Tissues/Organs
- Other
- tumor metastasis
- Increased Tumor Incidence
Mammalian Phenotype Terms by Genotype
Genotype: Tg(MMTV-PyVT)634Mul/0
FVB/N-Tg(MMTV-PyVT)634Mul/J
endocrine/exocrine gland phenotype
- increased mammary gland tumor incidence
integument phenotype
- increased mammary gland tumor incidence
neoplasm
- abnormal tumor morphology
- metastatic lung tumors exhibit more blood vessel staining compared with equivalent tumors in Mmp9tm1Tvu/Mmp9tm1Tvu Tg(MMTV-PyVT)634Mul mice (MGI Ref ID J:140033)
- increased mammary gland tumor incidence
- increased tumor growth/size
- proliferation and apoptosis of tumor cells are increased compared with cells from Mmp9tm1Tvu/Mmp9tm1Tvu Tg(MMTV-PyVT)634Mul mice with the balance resulting in increased tumor size (MGI Ref ID J:140033)
respiratory system phenotype
- increased lung weight
- (MGI Ref ID J:147458)
Genotype: Tg(MMTV-PyVT)634Mul/0
FVB/N-Tg(MMTV-PyVT)634Mul
neoplasm
- increased mammary adenocarcinoma incidence
- (MGI Ref ID J:48285)
- all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (MGI Ref ID J:46460)
- mammary tumors appear in males and females with 100% penetrance by 40 days of age (MGI Ref ID J:51424)
- tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (MGI Ref ID J:46460)
- increased metastatic potential
endocrine/exocrine gland phenotype
- increased mammary adenocarcinoma incidence
- (MGI Ref ID J:48285)
- all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (MGI Ref ID J:46460)
- mammary tumors appear in males and females with 100% penetrance by 40 days of age (MGI Ref ID J:51424)
- tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (MGI Ref ID J:46460)
- lactation failure
- inability to lactate from the time of the first pregnancy (MGI Ref ID J:46460)
integument phenotype
- increased mammary adenocarcinoma incidence
- (MGI Ref ID J:48285)
- all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (MGI Ref ID J:46460)
- mammary tumors appear in males and females with 100% penetrance by 40 days of age (MGI Ref ID J:51424)
- tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (MGI Ref ID J:46460)
- lactation failure
- inability to lactate from the time of the first pregnancy (MGI Ref ID J:46460)
Genotype: Tg(MMTV-PyVT)634Mul/0
involves: FVB/N
neoplasm
- increased mammary gland tumor incidence
- average onset of tumor development is 66 days (MGI Ref ID J:133325)
- extensive adenomas are found (MGI Ref ID J:133325)
- primary tumors are highly fibrotic (MGI Ref ID J:236031)
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (MGI Ref ID J:236031)
- tumors have higher CD31 staining, indicating increased primary tumor vasculature (MGI Ref ID J:236031)
endocrine/exocrine gland phenotype
- abnormal mammary gland morphology
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- increased mammary gland tumor incidence
- average onset of tumor development is 66 days (MGI Ref ID J:133325)
- extensive adenomas are found (MGI Ref ID J:133325)
- primary tumors are highly fibrotic (MGI Ref ID J:236031)
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (MGI Ref ID J:236031)
- tumors have higher CD31 staining, indicating increased primary tumor vasculature (MGI Ref ID J:236031)
integument phenotype
- abnormal mammary gland morphology
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- increased mammary gland tumor incidence
- average onset of tumor development is 66 days (MGI Ref ID J:133325)
- extensive adenomas are found (MGI Ref ID J:133325)
- primary tumors are highly fibrotic (MGI Ref ID J:236031)
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (MGI Ref ID J:236031)
- tumors have higher CD31 staining, indicating increased primary tumor vasculature (MGI Ref ID J:236031)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tg(MMTV-PyVT)634Mul/0
multiple strains
endocrine/exocrine gland phenotype
- decreased mammary gland tumor incidence
- in F1 FVB/N mice crossed to the P/J, DBA/1J, NZW/LacJ, C57BL/6NIcr, CAST/Ei, NOD/LtJ, CBA/CaJ, SWR/J, AKR/J, BUB/BnJ, ST/J, KK/HiJ, or MOLF/Ei strains, an increased latency of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N straininbred FVB/N strain (MGI Ref ID J:48854)
- increased mammary adenocarcinoma incidence
- in F1 FVB/N mice crossed to either the I/LnJ or C58/J strains, an acceleration of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N strain (MGI Ref ID J:48854)
integument phenotype
- decreased mammary gland tumor incidence
- in F1 FVB/N mice crossed to the P/J, DBA/1J, NZW/LacJ, C57BL/6NIcr, CAST/Ei, NOD/LtJ, CBA/CaJ, SWR/J, AKR/J, BUB/BnJ, ST/J, KK/HiJ, or MOLF/Ei strains, an increased latency of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N straininbred FVB/N strain (MGI Ref ID J:48854)
- increased mammary adenocarcinoma incidence
- in F1 FVB/N mice crossed to either the I/LnJ or C58/J strains, an acceleration of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N strain (MGI Ref ID J:48854)
neoplasm
- decreased mammary gland tumor incidence
- in F1 FVB/N mice crossed to the P/J, DBA/1J, NZW/LacJ, C57BL/6NIcr, CAST/Ei, NOD/LtJ, CBA/CaJ, SWR/J, AKR/J, BUB/BnJ, ST/J, KK/HiJ, or MOLF/Ei strains, an increased latency of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N straininbred FVB/N strain (MGI Ref ID J:48854)
- decreased metastatic potential
- in F1 FVB/N mice crossed to the RF/J, C58/J, C57BR/cdJ, NZB/B1NJ, I/LnJ, DBA/2J, KK/HiJ, MOLF/Ei, SEA/GnJ, NZW/LacJ, or CE/J strains, an decrease in pulmonary metastatic index is seen (MGI Ref ID J:48854)
- increased mammary adenocarcinoma incidence
- in F1 FVB/N mice crossed to either the I/LnJ or C58/J strains, an acceleration of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N strain (MGI Ref ID J:48854)
- increased metastatic potential
- in F1 FVB/N mice crossed to the AKR/J strain, an increase in pulmonary metastatic index is seen (MGI Ref ID J:48854)
Genotype: Tg(MMTV-PyVT)634Mul/0
involves: 129 * C57BL/6 * FVB/N
endocrine/exocrine gland phenotype
- increased mammary adenocarcinoma incidence
- all female virgin mice develop cancer tumors in the breast by 14 weeks of age (MGI Ref ID J:117336)
integument phenotype
- increased mammary adenocarcinoma incidence
- all female virgin mice develop cancer tumors in the breast by 14 weeks of age (MGI Ref ID J:117336)
neoplasm
- increased mammary adenocarcinoma incidence
- all female virgin mice develop cancer tumors in the breast by 14 weeks of age (MGI Ref ID J:117336)
Genotype: Tg(MMTV-PyVT)634Mul/0
involves: C57BL/6 * FVB/N
endocrine/exocrine gland phenotype
- increased mammary gland tumor incidence
- mice develop mammary gland tumors with a median age of tumor latency of 73 days in females and 137 days in males unlike wild-type mice (MGI Ref ID J:147458)
integument phenotype
- increased mammary gland tumor incidence
- mice develop mammary gland tumors with a median age of tumor latency of 73 days in females and 137 days in males unlike wild-type mice (MGI Ref ID J:147458)
neoplasm
- increased mammary gland tumor incidence
- mice develop mammary gland tumors with a median age of tumor latency of 73 days in females and 137 days in males unlike wild-type mice (MGI Ref ID J:147458)
respiratory system phenotype
- increased lung weight
- (MGI Ref ID J:147458)
Phenotype Information
References
- Guy CT; Cardiff RD; Muller WJ. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12(3):954-61. PubMed: 1312220MGI: J:46460
Additional References
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Additional - Tg(MMTV-PyVT)634Mul related
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