JAX
Mouse Strain Datasheet - 002374
FVB/N-Tg(MMTV-PyVT)634Mul/J
Also Known As: MMTV-PyMT
Hemizygous MMTV-PyMT females develop palpable mammary tumors which metastasize to the lung. These mice have high penetrance and early onset of mammary cancer compared to other mammary tumor models. Male carriers also develop mammary tumors with a later age of onset. MMTV-PyVT transgenic mice express the Polyoma Virus middle T antigen under the direction of the mouse mammary tumor virus promoter/enhancer.
Donating Investigator
Dr. William Muller, McGill University
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N18+N1F2
|
Tg(MMTV-PyVT)634Mul
| Allele Type |
|---|
| Transgenic (Inserted expressed sequence) |
Base Price
Starting at:
| $246.50 Domestic price for female |
| $329.00 Domestic price for breeder pair |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cancer Research
- Increased Tumor Incidence
- Gonadal Tumors
- Mammary Gland Tumors
- Other Tissues/Organs
- Other
- tumor metastasis
- Increased Tumor Incidence
Mammalian Phenotype Terms by Genotype
Genotype: Tg(MMTV-PyVT)634Mul/0
FVB/N-Tg(MMTV-PyVT)634Mul/J
endocrine/exocrine gland phenotype
- increased mammary gland tumor incidence
integument phenotype
- increased mammary gland tumor incidence
neoplasm
- abnormal tumor morphology
- metastatic lung tumors exhibit more blood vessel staining compared with equivalent tumors in Mmp9tm1Tvu/Mmp9tm1Tvu Tg(MMTV-PyVT)634Mul mice (MGI Ref ID J:140033)
- increased mammary gland tumor incidence
- increased tumor growth/size
- proliferation and apoptosis of tumor cells are increased compared with cells from Mmp9tm1Tvu/Mmp9tm1Tvu Tg(MMTV-PyVT)634Mul mice with the balance resulting in increased tumor size (MGI Ref ID J:140033)
respiratory system phenotype
- increased lung weight
- (MGI Ref ID J:147458)
Genotype: Tg(MMTV-PyVT)634Mul/0
FVB/N-Tg(MMTV-PyVT)634Mul
neoplasm
- increased mammary adenocarcinoma incidence
- (MGI Ref ID J:48285)
- all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (MGI Ref ID J:46460)
- mammary tumors appear in males and females with 100% penetrance by 40 days of age (MGI Ref ID J:51424)
- tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (MGI Ref ID J:46460)
- increased metastatic potential
endocrine/exocrine gland phenotype
- increased mammary adenocarcinoma incidence
- (MGI Ref ID J:48285)
- all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (MGI Ref ID J:46460)
- mammary tumors appear in males and females with 100% penetrance by 40 days of age (MGI Ref ID J:51424)
- tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (MGI Ref ID J:46460)
- lactation failure
- inability to lactate from the time of the first pregnancy (MGI Ref ID J:46460)
integument phenotype
- increased mammary adenocarcinoma incidence
- (MGI Ref ID J:48285)
- all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (MGI Ref ID J:46460)
- mammary tumors appear in males and females with 100% penetrance by 40 days of age (MGI Ref ID J:51424)
- tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (MGI Ref ID J:46460)
- lactation failure
- inability to lactate from the time of the first pregnancy (MGI Ref ID J:46460)
Genotype: Tg(MMTV-PyVT)634Mul/0
involves: FVB/N
neoplasm
- increased mammary gland tumor incidence
- average onset of tumor development is 66 days (MGI Ref ID J:133325)
- extensive adenomas are found (MGI Ref ID J:133325)
- primary tumors are highly fibrotic (MGI Ref ID J:236031)
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (MGI Ref ID J:236031)
- tumors have higher CD31 staining, indicating increased primary tumor vasculature (MGI Ref ID J:236031)
endocrine/exocrine gland phenotype
- abnormal mammary gland morphology
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- increased mammary gland tumor incidence
- average onset of tumor development is 66 days (MGI Ref ID J:133325)
- extensive adenomas are found (MGI Ref ID J:133325)
- primary tumors are highly fibrotic (MGI Ref ID J:236031)
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (MGI Ref ID J:236031)
- tumors have higher CD31 staining, indicating increased primary tumor vasculature (MGI Ref ID J:236031)
integument phenotype
- abnormal mammary gland morphology
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- increased mammary gland tumor incidence
- average onset of tumor development is 66 days (MGI Ref ID J:133325)
- extensive adenomas are found (MGI Ref ID J:133325)
- primary tumors are highly fibrotic (MGI Ref ID J:236031)
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (MGI Ref ID J:236031)
- tumors have higher CD31 staining, indicating increased primary tumor vasculature (MGI Ref ID J:236031)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tg(MMTV-PyVT)634Mul/0
multiple strains
endocrine/exocrine gland phenotype
- decreased mammary gland tumor incidence
- in F1 FVB/N mice crossed to the P/J, DBA/1J, NZW/LacJ, C57BL/6NIcr, CAST/Ei, NOD/LtJ, CBA/CaJ, SWR/J, AKR/J, BUB/BnJ, ST/J, KK/HiJ, or MOLF/Ei strains, an increased latency of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N straininbred FVB/N strain (MGI Ref ID J:48854)
- increased mammary adenocarcinoma incidence
- in F1 FVB/N mice crossed to either the I/LnJ or C58/J strains, an acceleration of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N strain (MGI Ref ID J:48854)
integument phenotype
- decreased mammary gland tumor incidence
- in F1 FVB/N mice crossed to the P/J, DBA/1J, NZW/LacJ, C57BL/6NIcr, CAST/Ei, NOD/LtJ, CBA/CaJ, SWR/J, AKR/J, BUB/BnJ, ST/J, KK/HiJ, or MOLF/Ei strains, an increased latency of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N straininbred FVB/N strain (MGI Ref ID J:48854)
- increased mammary adenocarcinoma incidence
- in F1 FVB/N mice crossed to either the I/LnJ or C58/J strains, an acceleration of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N strain (MGI Ref ID J:48854)
neoplasm
- decreased mammary gland tumor incidence
- in F1 FVB/N mice crossed to the P/J, DBA/1J, NZW/LacJ, C57BL/6NIcr, CAST/Ei, NOD/LtJ, CBA/CaJ, SWR/J, AKR/J, BUB/BnJ, ST/J, KK/HiJ, or MOLF/Ei strains, an increased latency of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N straininbred FVB/N strain (MGI Ref ID J:48854)
- decreased metastatic potential
- in F1 FVB/N mice crossed to the RF/J, C58/J, C57BR/cdJ, NZB/B1NJ, I/LnJ, DBA/2J, KK/HiJ, MOLF/Ei, SEA/GnJ, NZW/LacJ, or CE/J strains, an decrease in pulmonary metastatic index is seen (MGI Ref ID J:48854)
- increased mammary adenocarcinoma incidence
- in F1 FVB/N mice crossed to either the I/LnJ or C58/J strains, an acceleration of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N strain (MGI Ref ID J:48854)
- increased metastatic potential
- in F1 FVB/N mice crossed to the AKR/J strain, an increase in pulmonary metastatic index is seen (MGI Ref ID J:48854)
Genotype: Tg(MMTV-PyVT)634Mul/0
involves: 129 * C57BL/6 * FVB/N
endocrine/exocrine gland phenotype
- increased mammary adenocarcinoma incidence
- all female virgin mice develop cancer tumors in the breast by 14 weeks of age (MGI Ref ID J:117336)
integument phenotype
- increased mammary adenocarcinoma incidence
- all female virgin mice develop cancer tumors in the breast by 14 weeks of age (MGI Ref ID J:117336)
neoplasm
- increased mammary adenocarcinoma incidence
- all female virgin mice develop cancer tumors in the breast by 14 weeks of age (MGI Ref ID J:117336)
Genotype: Tg(MMTV-PyVT)634Mul/0
involves: C57BL/6 * FVB/N
endocrine/exocrine gland phenotype
- increased mammary gland tumor incidence
- mice develop mammary gland tumors with a median age of tumor latency of 73 days in females and 137 days in males unlike wild-type mice (MGI Ref ID J:147458)
integument phenotype
- increased mammary gland tumor incidence
- mice develop mammary gland tumors with a median age of tumor latency of 73 days in females and 137 days in males unlike wild-type mice (MGI Ref ID J:147458)
neoplasm
- increased mammary gland tumor incidence
- mice develop mammary gland tumors with a median age of tumor latency of 73 days in females and 137 days in males unlike wild-type mice (MGI Ref ID J:147458)
respiratory system phenotype
- increased lung weight
- (MGI Ref ID J:147458)
Phenotype Information
References
- Guy CT; Cardiff RD; Muller WJ. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.. In: . . MGI: J:46460
Additional References
- Le Voyer T; Rouse J; Lu Z; Lifsted T; Williams M; Hunter KW. 2001. Three loci modify growth of a transgene-induced mammary tumor: suppression of proliferation associated with decreased microvessel density.. In: . . MGI: J:70229
- Muraoka RS; Dumont N; Ritter CA; Dugger TC; Brantley DM; Chen J; Easterly E; Roebuck LR; Ryan S; Gotwals PJ; Koteliansky V; Arteaga CL. 2002. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.. In: . . MGI: J:86709
- Politi K; Kljuic A; Szabolcs M; Fisher P; Ludwig T; Efstratiadis A. 2004. 'Designer' tumors in mice.. In: . . MGI: J:87544
- Saez E; Rosenfeld J; Livolsi A; Olson P; Lombardo E; Nelson M; Banayo E; Cardiff RD; Izpisua-Belmonte JC; Evans RM. 2004. PPAR gamma signaling exacerbates mammary gland tumor development.. In: . . MGI: J:89019
Additional - Tg(MMTV-PyVT)634Mul related
- Ahn R; Sabourin V; Ha JR; Cory S; Maric G; Im YK; Hardy WR; Zhao H; Park M; Hallett M; Siegel PM; Pawson T; Ursini-Siegel J. 2013. The ShcA PTB Domain Functions as a Biological Sensor of Phosphotyrosine Signaling during Breast Cancer Progression.. In: . . MGI: J:199117
- Al Masri A; Gendler SJ. 2005. Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis.. In: . . MGI: J:101766
- Alba-Castellon L; Olivera-Salguero R; Mestre-Farrera A; Pena R; Herrera M; Bonilla F; Casal JI; Baulida J; Pena C; Garcia de Herreros A. 2016. Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis.. In: . . MGI: J:236860
- Albright CD; Salganik RI; Van Dyke T. 2004. Dietary depletion of vitamin e and vitamin a inhibits mammary tumor growth and metastasis in transgenic mice.. In: . . MGI: J:90173
- Almholt K; Juncker-Jensen A; Laerum OD; Dano K; Johnsen M; Lund LR; Romer J. 2008. Metastasis is strongly reduced by the matrix metalloproteinase inhibitor Galardin in the MMTV-PymT transgenic breast cancer model.. In: . . MGI: J:152124
- Almholt K; Lund LR; Rygaard J; Nielsen BS; Dano K; Romer J; Johnsen M. 2005. Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice.. In: . . MGI: J:94645
- Arun G; Diermeier S; Akerman M; Chang KC; Wilkinson JE; Hearn S; Kim Y; MacLeod AR; Krainer AR; Norton L; Brogi E; Egeblad M; Spector DL. 2016. Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss.. In: . . MGI: J:227688
- Asrani K; Keri RA; Galisteo R; Brown SA; Morgan SJ; Ghosh A; Tran NL; Winkles JA. 2013. The HER2- and heregulin beta1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression.. In: . . MGI: J:205464
- Asselin-Labat ML; Sutherland KD; Vaillant F; Gyorki DE; Wu D; Holroyd S; Breslin K; Ward T; Shi W; Bath ML; Deb S; Fox SB; Smyth GK; Lindeman GJ; Visvader JE. 2011. Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.. In: . . MGI: J:178780
- Babu E; Bhutia YD; Ramachandran S; Gnanaprakasam JP; Prasad PD; Thangaraju M; Ganapathy V. 2015. Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer.. In: . . MGI: J:226105
- Bachawal SV; Jensen KC; Lutz AM; Gambhir SS; Tranquart F; Tian L; Willmann JK. 2013. Earlier detection of breast cancer with ultrasound molecular imaging in a transgenic mouse model.. In: . . MGI: J:196899
- Bachawal SV; Jensen KC; Wilson KE; Tian L; Lutz AM; Willmann JK. 2015. Breast Cancer Detection by B7-H3-Targeted Ultrasound Molecular Imaging.. In: . . MGI: J:222692
- Baenke F; Dubuis S; Brault C; Weigelt B; Dankworth B; Griffiths B; Jiang M; Mackay A; Saunders B; Spencer-Dene B; Ros S; Stamp G; Reis-Filho JS; Howell M; Zamboni N; Schulze A. 2015. Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival.. In: . . MGI: J:225613
- Baird JR; Friedman D; Cottam B; Dubensky TW Jr; Kanne DB; Bambina S; Bahjat K; Crittenden MR; Gough MJ. 2016. Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors.. In: . . MGI: J:237566
- Balboni AL; Hutchinson JA; DeCastro AJ; Cherukuri P; Liby K; Sporn MB; Schwartz GN; Wells WA; Sempere LF; Yu PB; DiRenzo J. 2013. DeltaNp63alpha-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells.. In: . . MGI: J:194364
- Basu GD; Pathangey LB; Tinder TL; Lagioia M; Gendler SJ; Mukherjee P. 2004. Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer.. In: . . MGI: J:94659
- Basu GD; Tinder TL; Bradley JM; Tu T; Hattrup CL; Pockaj BA; Mukherjee P. 2006. Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: role of IDO.. In: . . MGI: J:138387
- Beerling E; Seinstra D; de Wit E; Kester L; van der Velden D; Maynard C; Schafer R; van Diest P; Voest E; van Oudenaarden A; Vrisekoop N; van Rheenen J. 2016. Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity.. In: . . MGI: J:234349
- Bentires-Alj M; Neel BG. 2007. Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.. In: . . MGI: J:120339
- Berger T; Cheung CC; Elia AJ; Mak TW. 2010. Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.. In: . . MGI: J:157568
- Berger T; Ueda T; Arpaia E; Chio II; Shirdel EA; Jurisica I; Hamada K; You-Ten A; Haight J; Wakeham A; Cheung CC; Mak TW. 2013. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model.. In: . . MGI: J:203238
- Beristain AG; Molyneux SD; Joshi PA; Pomroy NC; Di Grappa MA; Chang MC; Kirschner LS; Prive GG; Pujana MA; Khokha R. 2015. PKA signaling drives mammary tumorigenesis through Src.. In: . . MGI: J:219256
- Bierie B; Stover DG; Abel TW; Chytil A; Gorska AE; Aakre M; Forrester E; Yang L; Wagner KU; Moses HL. 2008. Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment.. In: . . MGI: J:133311
- Bist P; Leow SC; Phua QH; Shu S; Zhuang Q; Loh WT; Nguyen TH; Zhou JB; Hooi SC; Lim LH. 2011. Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-kappaB: implication in breast cancer metastasis.. In: . . MGI: J:174635
- Bordeleau F; Califano JP; Negron Abril YL; Mason BN; LaValley DJ; Shin SJ; Weiss RS; Reinhart-King CA. 2015. Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors.. In: . . MGI: J:223734
- Bordeleau F; Mason BN; Lollis EM; Mazzola M; Zanotelli MR; Somasegar S; Califano JP; Montague C; LaValley DJ; Huynh J; Mencia-Trinchant N; Negron Abril YL; Hassane DC; Bonassar LJ; Butcher JT; Weiss RS; Reinhart-King CA. 2017. Matrix stiffening promotes a tumor vasculature phenotype.. In: . . MGI: J:239542
- Brantley-Sieders DM; Zhuang G; Hicks D; Fang WB; Hwang Y; Cates JM; Coffman K; Jackson D; Bruckheimer E; Muraoka-Cook RS; Chen J. 2008. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling.. In: . . MGI: J:130805
- Braumuller H; Wieder T; Brenner E; Assmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Haring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Rocken M. 2013. T-helper-1-cell cytokines drive cancer into senescence.. In: . . MGI: J:194546
- Bu W; Chen J; Morrison GD; Huang S; Creighton CJ; Huang J; Chamness GC; Hilsenbeck SG; Roop DR; Leavitt AD; Li Y. 2011. Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer.. In: . . MGI: J:178580
- Bugge TH; Lund LR; Kombrinck KK; Nielsen BS; Holmback K; Drew AF; Flick MJ; Witte DP; Dano K; Degen JL. 1998. Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice.. In: . . MGI: J:48285
- Butinar M; Prebanda MT; Rajkovic J; Jeric B; Stoka V; Peters C; Reinheckel T; Kruger A; Turk V; Turk B; Vasiljeva O. 2014. Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model.. In: . . MGI: J:212612
- Cai Y; Nogales-Cadenas R; Zhang Q; Lin JR; Zhang W; O'Brien K; Montagna C; Zhang ZD. 2017. Transcriptomic dynamics of breast cancer progression in the MMTV-PyMT mouse model.. In: . . MGI: J:241531
- Cao Y; Luo JL; Karin M. 2007. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells.. In: . . MGI: J:125555
- Casbon AJ; Reynaud D; Park C; Khuc E; Gan DD; Schepers K; Passegue E; Werb Z. 2015. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.. In: . . MGI: J:220022
- Cedervall J; Zhang Y; Huang H; Zhang L; Femel J; Dimberg A; Olsson AK. 2015. Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals.. In: . . MGI: J:223032
- Chang SH; Elemento O; Zhang J; Zhuang ZW; Simons M; Hla T. 2014. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.. In: . . MGI: J:216804
- Chen D; Goswami CP; Burnett RM; Anjanappa M; Bhat-Nakshatri P; Muller W; Nakshatri H. 2014. Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle.. In: . . MGI: J:214245
- Chen P; O'Neal JF; Ebelt ND; Cantrell MA; Mitra S; Nasrazadani A; Vandenbroek TL; Heasley LE; Van Den Berg CL. 2010. Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model.. In: . . MGI: J:160923
- Chen Z; Zhang Y; Jia C; Wang Y; Lai P; Zhou X; Wang Y; Song Q; Lin J; Ren Z; Gao Q; Zhao Z; Zheng H; Wan Z; Gao T; Zhao A; Dai Y; Bai X. 2014. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.. In: . . MGI: J:214352
- Cheng AM; Saxton TM; Sakai R; Kulkarni S; Mbamalu G; Vogel W; Tortorice CG; Cardiff RD; Cross JC; Muller WJ; Pawson T. 1998. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.. In: . . MGI: J:51424
- Cheung KJ; Gabrielson E; Werb Z; Ewald AJ. 2013. Collective invasion in breast cancer requires a conserved basal epithelial program.. In: . . MGI: J:205494
- Cheung KJ; Padmanaban V; Silvestri V; Schipper K; Cohen JD; Fairchild AN; Gorin MA; Verdone JE; Pienta KJ; Bader JS; Ewald AJ. 2016. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters.. In: . . MGI: J:230438
- Chourasia AH; Tracy K; Frankenberger C; Boland ML; Sharifi MN; Drake LE; Sachleben JR; Asara JM; Locasale JW; Karczmar GS; Macleod KF. 2015. Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.. In: . . MGI: J:224832
- Clark-Knowles KV; Dewar-Darch D; Jardine KE; McBurney MW. 2013. SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.. In: . . MGI: J:209772
- Clark-Knowles KV; Dewar-Darch D; Jardine KE; McBurney MW. 2014. Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity.. In: . . MGI: J:225313
- Cook RS; Jacobsen KM; Wofford AM; DeRyckere D; Stanford J; Prieto AL; Redente E; Sandahl M; Hunter DM; Strunk KE; Graham DK; Earp HS 3rd. 2013. MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.. In: . . MGI: J:201406
- Coombs GS; Schmitt AA; Canning CA; Alok A; Low IC; Banerjee N; Kaur S; Utomo V; Jones CM; Pervaiz S; Toone EJ; Virshup DM. 2012. Modulation of Wnt/beta-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer.. In: . . MGI: J:179415
- Corsa CA; Brenot A; Grither WR; Van Hove S; Loza AJ; Zhang K; Ponik SM; Liu Y; DeNardo DG; Eliceiri KW; Keely PJ; Longmore GD. 2016. The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis.. In: . . MGI: J:236031
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- Cramer EP; Glenthoj A; Hager M; Juncker-Jensen A; Engelholm LH; Santoni-Rugiu E; Lund LR; Laerum OD; Cowland JB; Borregaard N. 2012. No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer.. In: . . MGI: J:187808
- Cuevas BD; Winter-Vann AM; Johnson NL; Johnson GL. 2006. MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer.. In: . . MGI: J:112298
- Curino AC; Engelholm LH; Yamada SS; Holmbeck K; Lund LR; Molinolo AA; Behrendt N; Nielsen BS; Bugge TH. 2005. Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy.. In: . . MGI: J:99636
- Dadachova E; Nguyen A; Lin EY; Gnatovskiy L; Lu P; Pollard JW. 2005. Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth.. In: . . MGI: J:103586
- Dai L; Guinea MC; Slomiany MG; Bratoeva M; Grass GD; Tolliver LB; Maria BL; Toole BP. 2013. CD147-Dependent Heterogeneity in Malignant and Chemoresistant Properties of Cancer Cells.. In: . . MGI: J:192310
- Davie SA; Maglione JE; Manner CK; Young D; Cardiff RD; MacLeod CL; Ellies LG. 2007. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice.. In: . . MGI: J:121391
- De Palma M; Mazzieri R; Politi LS; Pucci F; Zonari E; Sitia G; Mazzoleni S; Moi D; Venneri MA; Indraccolo S; Falini A; Guidotti LG; Galli R; Naldini L. 2008. Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis.. In: . . MGI: J:140090
- DeNardo DG; Barreto JB; Andreu P; Vasquez L; Tawfik D; Kolhatkar N; Coussens LM. 2009. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.. In: . . MGI: J:151976
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- Du J; Yang M; Chen S; Li D; Chang Z; Dong Z. 2015. PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model.. In: . . MGI: J:226089
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