JAX
Mouse Strain Datasheet - 002374
FVB/N-Tg(MMTV-PyVT)634Mul/J
Also Known As: MMTV-PyMT
Hemizygous MMTV-PyMT females develop palpable mammary tumors which metastasize to the lung. These mice have high penetrance and early onset of mammary cancer compared to other mammary tumor models. Male carriers also develop mammary tumors with a later age of onset. MMTV-PyVT transgenic mice express the Polyoma Virus middle T antigen under the direction of the mouse mammary tumor virus promoter/enhancer.
Donating Investigator
Dr. William Muller, McGill University
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N18+N1F2
|
Tg(MMTV-PyVT)634Mul
| Allele Type |
|---|
| Transgenic (Inserted expressed sequence) |
Base Price
Starting at:
| $246.50 Domestic price for female |
| $329.00 Domestic price for breeder pair |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cancer Research
- Increased Tumor Incidence
- Gonadal Tumors
- Mammary Gland Tumors
- Other Tissues/Organs
- Other
- tumor metastasis
- Increased Tumor Incidence
Mammalian Phenotype Terms by Genotype
Genotype: Tg(MMTV-PyVT)634Mul/0
FVB/N-Tg(MMTV-PyVT)634Mul/J
endocrine/exocrine gland phenotype
- increased mammary gland tumor incidence
integument phenotype
- increased mammary gland tumor incidence
neoplasm
- abnormal tumor morphology
- metastatic lung tumors exhibit more blood vessel staining compared with equivalent tumors in Mmp9tm1Tvu/Mmp9tm1Tvu Tg(MMTV-PyVT)634Mul mice (MGI Ref ID J:140033)
- increased mammary gland tumor incidence
- increased tumor growth/size
- proliferation and apoptosis of tumor cells are increased compared with cells from Mmp9tm1Tvu/Mmp9tm1Tvu Tg(MMTV-PyVT)634Mul mice with the balance resulting in increased tumor size (MGI Ref ID J:140033)
respiratory system phenotype
- increased lung weight
- (MGI Ref ID J:147458)
Genotype: Tg(MMTV-PyVT)634Mul/0
FVB/N-Tg(MMTV-PyVT)634Mul
neoplasm
- increased mammary adenocarcinoma incidence
- (MGI Ref ID J:48285)
- all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (MGI Ref ID J:46460)
- mammary tumors appear in males and females with 100% penetrance by 40 days of age (MGI Ref ID J:51424)
- tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (MGI Ref ID J:46460)
- increased metastatic potential
endocrine/exocrine gland phenotype
- increased mammary adenocarcinoma incidence
- (MGI Ref ID J:48285)
- all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (MGI Ref ID J:46460)
- mammary tumors appear in males and females with 100% penetrance by 40 days of age (MGI Ref ID J:51424)
- tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (MGI Ref ID J:46460)
- lactation failure
- inability to lactate from the time of the first pregnancy (MGI Ref ID J:46460)
integument phenotype
- increased mammary adenocarcinoma incidence
- (MGI Ref ID J:48285)
- all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (MGI Ref ID J:46460)
- mammary tumors appear in males and females with 100% penetrance by 40 days of age (MGI Ref ID J:51424)
- tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (MGI Ref ID J:46460)
- lactation failure
- inability to lactate from the time of the first pregnancy (MGI Ref ID J:46460)
Genotype: Tg(MMTV-PyVT)634Mul/0
involves: FVB/N
neoplasm
- increased mammary gland tumor incidence
- average onset of tumor development is 66 days (MGI Ref ID J:133325)
- extensive adenomas are found (MGI Ref ID J:133325)
- primary tumors are highly fibrotic (MGI Ref ID J:236031)
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (MGI Ref ID J:236031)
- tumors have higher CD31 staining, indicating increased primary tumor vasculature (MGI Ref ID J:236031)
endocrine/exocrine gland phenotype
- abnormal mammary gland morphology
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- increased mammary gland tumor incidence
- average onset of tumor development is 66 days (MGI Ref ID J:133325)
- extensive adenomas are found (MGI Ref ID J:133325)
- primary tumors are highly fibrotic (MGI Ref ID J:236031)
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (MGI Ref ID J:236031)
- tumors have higher CD31 staining, indicating increased primary tumor vasculature (MGI Ref ID J:236031)
integument phenotype
- abnormal mammary gland morphology
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- increased mammary gland tumor incidence
- average onset of tumor development is 66 days (MGI Ref ID J:133325)
- extensive adenomas are found (MGI Ref ID J:133325)
- primary tumors are highly fibrotic (MGI Ref ID J:236031)
- tumor nodules are present throughout the entire mammary gland (MGI Ref ID J:133325)
- tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (MGI Ref ID J:236031)
- tumors have higher CD31 staining, indicating increased primary tumor vasculature (MGI Ref ID J:236031)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tg(MMTV-PyVT)634Mul/0
multiple strains
endocrine/exocrine gland phenotype
- decreased mammary gland tumor incidence
- in F1 FVB/N mice crossed to the P/J, DBA/1J, NZW/LacJ, C57BL/6NIcr, CAST/Ei, NOD/LtJ, CBA/CaJ, SWR/J, AKR/J, BUB/BnJ, ST/J, KK/HiJ, or MOLF/Ei strains, an increased latency of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N straininbred FVB/N strain (MGI Ref ID J:48854)
- increased mammary adenocarcinoma incidence
- in F1 FVB/N mice crossed to either the I/LnJ or C58/J strains, an acceleration of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N strain (MGI Ref ID J:48854)
integument phenotype
- decreased mammary gland tumor incidence
- in F1 FVB/N mice crossed to the P/J, DBA/1J, NZW/LacJ, C57BL/6NIcr, CAST/Ei, NOD/LtJ, CBA/CaJ, SWR/J, AKR/J, BUB/BnJ, ST/J, KK/HiJ, or MOLF/Ei strains, an increased latency of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N straininbred FVB/N strain (MGI Ref ID J:48854)
- increased mammary adenocarcinoma incidence
- in F1 FVB/N mice crossed to either the I/LnJ or C58/J strains, an acceleration of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N strain (MGI Ref ID J:48854)
neoplasm
- decreased mammary gland tumor incidence
- in F1 FVB/N mice crossed to the P/J, DBA/1J, NZW/LacJ, C57BL/6NIcr, CAST/Ei, NOD/LtJ, CBA/CaJ, SWR/J, AKR/J, BUB/BnJ, ST/J, KK/HiJ, or MOLF/Ei strains, an increased latency of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N straininbred FVB/N strain (MGI Ref ID J:48854)
- decreased metastatic potential
- in F1 FVB/N mice crossed to the RF/J, C58/J, C57BR/cdJ, NZB/B1NJ, I/LnJ, DBA/2J, KK/HiJ, MOLF/Ei, SEA/GnJ, NZW/LacJ, or CE/J strains, an decrease in pulmonary metastatic index is seen (MGI Ref ID J:48854)
- increased mammary adenocarcinoma incidence
- in F1 FVB/N mice crossed to either the I/LnJ or C58/J strains, an acceleration of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N strain (MGI Ref ID J:48854)
- increased metastatic potential
- in F1 FVB/N mice crossed to the AKR/J strain, an increase in pulmonary metastatic index is seen (MGI Ref ID J:48854)
Genotype: Tg(MMTV-PyVT)634Mul/0
involves: 129 * C57BL/6 * FVB/N
endocrine/exocrine gland phenotype
- increased mammary adenocarcinoma incidence
- all female virgin mice develop cancer tumors in the breast by 14 weeks of age (MGI Ref ID J:117336)
integument phenotype
- increased mammary adenocarcinoma incidence
- all female virgin mice develop cancer tumors in the breast by 14 weeks of age (MGI Ref ID J:117336)
neoplasm
- increased mammary adenocarcinoma incidence
- all female virgin mice develop cancer tumors in the breast by 14 weeks of age (MGI Ref ID J:117336)
Genotype: Tg(MMTV-PyVT)634Mul/0
involves: C57BL/6 * FVB/N
endocrine/exocrine gland phenotype
- increased mammary gland tumor incidence
- mice develop mammary gland tumors with a median age of tumor latency of 73 days in females and 137 days in males unlike wild-type mice (MGI Ref ID J:147458)
integument phenotype
- increased mammary gland tumor incidence
- mice develop mammary gland tumors with a median age of tumor latency of 73 days in females and 137 days in males unlike wild-type mice (MGI Ref ID J:147458)
neoplasm
- increased mammary gland tumor incidence
- mice develop mammary gland tumors with a median age of tumor latency of 73 days in females and 137 days in males unlike wild-type mice (MGI Ref ID J:147458)
respiratory system phenotype
- increased lung weight
- (MGI Ref ID J:147458)
Phenotype Information
References
- Guy CT; Cardiff RD; Muller WJ. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12(3):954-61. PubMed: 1312220MGI: J:46460
Additional References
- Le Voyer T; Rouse J; Lu Z; Lifsted T; Williams M; Hunter KW. 2001. Three loci modify growth of a transgene-induced mammary tumor: suppression of proliferation associated with decreased microvessel density. Genomics 74(3):253-61. PubMed: 11414753MGI: J:70229
- Muraoka RS; Dumont N; Ritter CA; Dugger TC; Brantley DM; Chen J; Easterly E; Roebuck LR; Ryan S; Gotwals PJ; Koteliansky V; Arteaga CL. 2002. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest 109(12):1551-9. PubMed: 12070302MGI: J:86709
- Politi K; Kljuic A; Szabolcs M; Fisher P; Ludwig T; Efstratiadis A. 2004. 'Designer' tumors in mice. Oncogene 23(8):1558-65. PubMed: 14661057MGI: J:87544
- Saez E; Rosenfeld J; Livolsi A; Olson P; Lombardo E; Nelson M; Banayo E; Cardiff RD; Izpisua-Belmonte JC; Evans RM. 2004. PPAR gamma signaling exacerbates mammary gland tumor development. Genes Dev 18(5):528-40. PubMed: 15037548MGI: J:89019
Additional - Tg(MMTV-PyVT)634Mul related
- Ahn R; Sabourin V; Ha JR; Cory S; Maric G; Im YK; Hardy WR; Zhao H; Park M; Hallett M; Siegel PM; Pawson T; Ursini-Siegel J. 2013. The ShcA PTB Domain Functions as a Biological Sensor of Phosphotyrosine Signaling during Breast Cancer Progression. Cancer Res 73(14):4521-32. PubMed: 23695548MGI: J:199117
- Al Masri A; Gendler SJ. 2005. Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis. Oncogene 24(38):5799-808. PubMed: 15897873MGI: J:101766
- Alba-Castellon L; Olivera-Salguero R; Mestre-Farrera A; Pena R; Herrera M; Bonilla F; Casal JI; Baulida J; Pena C; Garcia de Herreros A. 2016. Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis. Cancer Res 76(21):6205-6217. PubMed: 27503928MGI: J:236860
- Albright CD; Salganik RI; Van Dyke T. 2004. Dietary depletion of vitamin e and vitamin a inhibits mammary tumor growth and metastasis in transgenic mice. J Nutr 134(5):1139-44. PubMed: 15113960MGI: J:90173
- Almholt K; Juncker-Jensen A; Laerum OD; Dano K; Johnsen M; Lund LR; Romer J. 2008. Metastasis is strongly reduced by the matrix metalloproteinase inhibitor Galardin in the MMTV-PymT transgenic breast cancer model. Mol Cancer Ther 7(9):2758-67. PubMed: 18790756MGI: J:152124
- Almholt K; Lund LR; Rygaard J; Nielsen BS; Dano K; Romer J; Johnsen M. 2005. Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice. Int J Cancer 113(4):525-32. PubMed: 15472905MGI: J:94645
- Arun G; Diermeier S; Akerman M; Chang KC; Wilkinson JE; Hearn S; Kim Y; MacLeod AR; Krainer AR; Norton L; Brogi E; Egeblad M; Spector DL. 2016. Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. Genes Dev 30(1):34-51. PubMed: 26701265MGI: J:227688
- Asrani K; Keri RA; Galisteo R; Brown SA; Morgan SJ; Ghosh A; Tran NL; Winkles JA. 2013. The HER2- and heregulin beta1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression. Mol Cancer Res 11(4):393-404. PubMed: 23378579MGI: J:205464
- Asselin-Labat ML; Sutherland KD; Vaillant F; Gyorki DE; Wu D; Holroyd S; Breslin K; Ward T; Shi W; Bath ML; Deb S; Fox SB; Smyth GK; Lindeman GJ; Visvader JE. 2011. Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14. Mol Cell Biol 31(22):4609-22. PubMed: 21930782MGI: J:178780
- Babu E; Bhutia YD; Ramachandran S; Gnanaprakasam JP; Prasad PD; Thangaraju M; Ganapathy V. 2015. Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer. Biochem J 469(1):17-23. PubMed: 26173258MGI: J:226105
- Bachawal SV; Jensen KC; Lutz AM; Gambhir SS; Tranquart F; Tian L; Willmann JK. 2013. Earlier detection of breast cancer with ultrasound molecular imaging in a transgenic mouse model. Cancer Res 73(6):1689-98. PubMed: 23328585MGI: J:196899
- Bachawal SV; Jensen KC; Wilson KE; Tian L; Lutz AM; Willmann JK. 2015. Breast Cancer Detection by B7-H3-Targeted Ultrasound Molecular Imaging. Cancer Res 75(12):2501-9. PubMed: 25899053MGI: J:222692
- Baenke F; Dubuis S; Brault C; Weigelt B; Dankworth B; Griffiths B; Jiang M; Mackay A; Saunders B; Spencer-Dene B; Ros S; Stamp G; Reis-Filho JS; Howell M; Zamboni N; Schulze A. 2015. Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival. J Pathol :. PubMed: 25965974MGI: J:225613
- Baird JR; Friedman D; Cottam B; Dubensky TW Jr; Kanne DB; Bambina S; Bahjat K; Crittenden MR; Gough MJ. 2016. Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors. Cancer Res 76(1):50-61. PubMed: 26567136MGI: J:237566
- Balboni AL; Hutchinson JA; DeCastro AJ; Cherukuri P; Liby K; Sporn MB; Schwartz GN; Wells WA; Sempere LF; Yu PB; DiRenzo J. 2013. DeltaNp63alpha-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Res 73(2):1020-30. PubMed: 23243027MGI: J:194364
- Basu GD; Pathangey LB; Tinder TL; Lagioia M; Gendler SJ; Mukherjee P. 2004. Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer. Mol Cancer Res 2(11):632-42. PubMed: 15561779MGI: J:94659
- Basu GD; Tinder TL; Bradley JM; Tu T; Hattrup CL; Pockaj BA; Mukherjee P. 2006. Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: role of IDO. J Immunol 177(4):2391-402. PubMed: 16888001MGI: J:138387
- Beerling E; Seinstra D; de Wit E; Kester L; van der Velden D; Maynard C; Schafer R; van Diest P; Voest E; van Oudenaarden A; Vrisekoop N; van Rheenen J. 2016. Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity. Cell Rep 14(10):2281-8. PubMed: 26947068MGI: J:234349
- Bentires-Alj M; Neel BG. 2007. Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer. Cancer Res 67(6):2420-4. PubMed: 17347513MGI: J:120339
- Berger T; Cheung CC; Elia AJ; Mak TW. 2010. Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis. Proc Natl Acad Sci U S A 107(7):2995-3000. PubMed: 20133630MGI: J:157568
- Berger T; Ueda T; Arpaia E; Chio II; Shirdel EA; Jurisica I; Hamada K; You-Ten A; Haight J; Wakeham A; Cheung CC; Mak TW. 2013. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene 32(41):4989-94. PubMed: 23146906MGI: J:203238
- Beristain AG; Molyneux SD; Joshi PA; Pomroy NC; Di Grappa MA; Chang MC; Kirschner LS; Prive GG; Pujana MA; Khokha R. 2015. PKA signaling drives mammary tumorigenesis through Src. Oncogene 34(9):1160-73. PubMed: 24662820MGI: J:219256
- Bierie B; Stover DG; Abel TW; Chytil A; Gorska AE; Aakre M; Forrester E; Yang L; Wagner KU; Moses HL. 2008. Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment. Cancer Res 68(6):1809-19. PubMed: 18339861MGI: J:133311
- Bist P; Leow SC; Phua QH; Shu S; Zhuang Q; Loh WT; Nguyen TH; Zhou JB; Hooi SC; Lim LH. 2011. Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-kappaB: implication in breast cancer metastasis. Oncogene 30(28):3174-85. PubMed: 21383699MGI: J:174635
- Bordeleau F; Califano JP; Negron Abril YL; Mason BN; LaValley DJ; Shin SJ; Weiss RS; Reinhart-King CA. 2015. Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors. Proc Natl Acad Sci U S A 112(27):8314-9. PubMed: 26106154MGI: J:223734
- Bordeleau F; Mason BN; Lollis EM; Mazzola M; Zanotelli MR; Somasegar S; Califano JP; Montague C; LaValley DJ; Huynh J; Mencia-Trinchant N; Negron Abril YL; Hassane DC; Bonassar LJ; Butcher JT; Weiss RS; Reinhart-King CA. 2017. Matrix stiffening promotes a tumor vasculature phenotype. Proc Natl Acad Sci U S A 114(3):492-497. PubMed: 28034921MGI: J:239542
- Brantley-Sieders DM; Zhuang G; Hicks D; Fang WB; Hwang Y; Cates JM; Coffman K; Jackson D; Bruckheimer E; Muraoka-Cook RS; Chen J. 2008. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest 118(1):64-78. PubMed: 18079969MGI: J:130805
- Braumuller H; Wieder T; Brenner E; Assmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Haring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Rocken M. 2013. T-helper-1-cell cytokines drive cancer into senescence. Nature 494(7437):361-5. PubMed: 23376950MGI: J:194546
- Bu W; Chen J; Morrison GD; Huang S; Creighton CJ; Huang J; Chamness GC; Hilsenbeck SG; Roop DR; Leavitt AD; Li Y. 2011. Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. Oncogene 30(43):4399-409. PubMed: 21532625MGI: J:178580
- Bugge TH; Lund LR; Kombrinck KK; Nielsen BS; Holmback K; Drew AF; Flick MJ; Witte DP; Dano K; Degen JL. 1998. Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice. Oncogene 16(24):3097-104. PubMed: 9671388MGI: J:48285
- Butinar M; Prebanda MT; Rajkovic J; Jeric B; Stoka V; Peters C; Reinheckel T; Kruger A; Turk V; Turk B; Vasiljeva O. 2014. Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model. Oncogene 33(26):3392-400. PubMed: 23955077MGI: J:212612
- Cai Y; Nogales-Cadenas R; Zhang Q; Lin JR; Zhang W; O'Brien K; Montagna C; Zhang ZD. 2017. Transcriptomic dynamics of breast cancer progression in the MMTV-PyMT mouse model. BMC Genomics 18(1):185. PubMed: 28212608MGI: J:241531
- Cao Y; Luo JL; Karin M. 2007. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A 104(40):15852-7. PubMed: 17890319MGI: J:125555
- Casbon AJ; Reynaud D; Park C; Khuc E; Gan DD; Schepers K; Passegue E; Werb Z. 2015. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc Natl Acad Sci U S A 112(6):E566-75. PubMed: 25624500MGI: J:220022
- Cedervall J; Zhang Y; Huang H; Zhang L; Femel J; Dimberg A; Olsson AK. 2015. Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals. Cancer Res 75(13):2653-62. PubMed: 26071254MGI: J:223032
- Chang SH; Elemento O; Zhang J; Zhuang ZW; Simons M; Hla T. 2014. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proc Natl Acad Sci U S A 111(51):18309-14. PubMed: 25422430MGI: J:216804
- Chen D; Goswami CP; Burnett RM; Anjanappa M; Bhat-Nakshatri P; Muller W; Nakshatri H. 2014. Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle. Cancer Res 74(16):4270-81. PubMed: 24980554MGI: J:214245
- Chen P; O'Neal JF; Ebelt ND; Cantrell MA; Mitra S; Nasrazadani A; Vandenbroek TL; Heasley LE; Van Den Berg CL. 2010. Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model. PLoS One 5(5):e10443. PubMed: 20454618MGI: J:160923
- Chen Z; Zhang Y; Jia C; Wang Y; Lai P; Zhou X; Wang Y; Song Q; Lin J; Ren Z; Gao Q; Zhao Z; Zheng H; Wan Z; Gao T; Zhao A; Dai Y; Bai X. 2014. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression. Oncogene 33(37):4548-57. PubMed: 24096482MGI: J:214352
- Cheng AM; Saxton TM; Sakai R; Kulkarni S; Mbamalu G; Vogel W; Tortorice CG; Cardiff RD; Cross JC; Muller WJ; Pawson T. 1998. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell 95(6):793-803. PubMed: 9865697MGI: J:51424
- Cheung KJ; Gabrielson E; Werb Z; Ewald AJ. 2013. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell 155(7):1639-51. PubMed: 24332913MGI: J:205494
- Cheung KJ; Padmanaban V; Silvestri V; Schipper K; Cohen JD; Fairchild AN; Gorin MA; Verdone JE; Pienta KJ; Bader JS; Ewald AJ. 2016. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters. Proc Natl Acad Sci U S A 113(7):E854-63. PubMed: 26831077MGI: J:230438
- Chourasia AH; Tracy K; Frankenberger C; Boland ML; Sharifi MN; Drake LE; Sachleben JR; Asara JM; Locasale JW; Karczmar GS; Macleod KF. 2015. Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. EMBO Rep 16(9):1145-63. PubMed: 26232272MGI: J:224832
- Clark-Knowles KV; Dewar-Darch D; Jardine KE; McBurney MW. 2013. SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer. PLoS One 8(11):e82106. PubMed: 24278473MGI: J:209772
- Clark-Knowles KV; Dewar-Darch D; Jardine KE; McBurney MW. 2014. Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity. PLoS One 9(11):e112406. PubMed: 25380034MGI: J:225313
- Cook RS; Jacobsen KM; Wofford AM; DeRyckere D; Stanford J; Prieto AL; Redente E; Sandahl M; Hunter DM; Strunk KE; Graham DK; Earp HS 3rd. 2013. MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis. J Clin Invest 123(8):3231-42. PubMed: 23867499MGI: J:201406
- Coombs GS; Schmitt AA; Canning CA; Alok A; Low IC; Banerjee N; Kaur S; Utomo V; Jones CM; Pervaiz S; Toone EJ; Virshup DM. 2012. Modulation of Wnt/beta-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer. Oncogene 31(2):213-25. PubMed: 21666721MGI: J:179415
- Corsa CA; Brenot A; Grither WR; Van Hove S; Loza AJ; Zhang K; Ponik SM; Liu Y; DeNardo DG; Eliceiri KW; Keely PJ; Longmore GD. 2016. The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis. Cell Rep 15(11):2510-23. PubMed: 27264173MGI: J:236031
- Cozma D; Lukes L; Rouse J; Qiu TH; Liu ET; Hunter KW. 2002. A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency modifiers. Genome Res 12(6):969-75. PubMed: 12045150MGI: J:77063
- Cramer EP; Glenthoj A; Hager M; Juncker-Jensen A; Engelholm LH; Santoni-Rugiu E; Lund LR; Laerum OD; Cowland JB; Borregaard N. 2012. No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer. PLoS One 7(6):e39646. PubMed: 22737251MGI: J:187808
- Cuevas BD; Winter-Vann AM; Johnson NL; Johnson GL. 2006. MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer. Oncogene 25(36):4998-5010. PubMed: 16568086MGI: J:112298
- Curino AC; Engelholm LH; Yamada SS; Holmbeck K; Lund LR; Molinolo AA; Behrendt N; Nielsen BS; Bugge TH. 2005. Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J Cell Biol 169(6):977-85. PubMed: 15967816MGI: J:99636
- Dadachova E; Nguyen A; Lin EY; Gnatovskiy L; Lu P; Pollard JW. 2005. Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth. Nucl Med Biol 32(7):695-700. PubMed: 16243644MGI: J:103586
- Dai L; Guinea MC; Slomiany MG; Bratoeva M; Grass GD; Tolliver LB; Maria BL; Toole BP. 2013. CD147-Dependent Heterogeneity in Malignant and Chemoresistant Properties of Cancer Cells. Am J Pathol 182(2):577-85. PubMed: 23178078MGI: J:192310
- Davie SA; Maglione JE; Manner CK; Young D; Cardiff RD; MacLeod CL; Ellies LG. 2007. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice. Transgenic Res 16(2):193-201. PubMed: 17206489MGI: J:121391
- De Palma M; Mazzieri R; Politi LS; Pucci F; Zonari E; Sitia G; Mazzoleni S; Moi D; Venneri MA; Indraccolo S; Falini A; Guidotti LG; Galli R; Naldini L. 2008. Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell 14(4):299-311. PubMed: 18835032MGI: J:140090
- DeNardo DG; Barreto JB; Andreu P; Vasquez L; Tawfik D; Kolhatkar N; Coussens LM. 2009. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16(2):91-102. PubMed: 19647220MGI: J:151976
- Deeb KK; Michalowska AM; Yoon CY; Krummey SM; Hoenerhoff MJ; Kavanaugh C; Li MC; Demayo FJ; Linnoila I; Deng CX; Lee EY; Medina D; Shih JH; Green JE. 2007. Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis. Cancer Res 67(17):8065-8080. PubMed: 17804718MGI: J:124885
- Dong D; Ni M; Li J; Xiong S; Ye W; Virrey JJ; Mao C; Ye R; Wang M; Pen L; Dubeau L; Groshen S; Hofman FM; Lee AS. 2008. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res 68(2):498-505. PubMed: 18199545MGI: J:131417
- Du J; Yang M; Chen S; Li D; Chang Z; Dong Z. 2015. PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model. Oncogene :. PubMed: 26455327MGI: J:226089
- Du Z; Podsypanina K; Huang S; McGrath A; Toneff MJ; Bogoslovskaia E; Zhang X; Moraes RC; Fluck M; Allred DC; Lewis MT; Varmus HE; Li Y. 2006. Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proc Natl Acad Sci U S A 103(46):17396-401. PubMed: 17090666MGI: J:117125
- Ellies LG. 2003. PyV-mT-induced parotid gland hyperplasia as detected by altered lectin reactivity is not modulated by inducible nitric oxide deficiency. Arch Oral Biol 48(6):415-22. PubMed: 12749913MGI: J:84218
- Ellies LG; Fishman M; Hardison J; Kleeman J; Maglione JE; Manner CK; Cardiff RD; MacLeod CL. 2003. Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase. Int J Cancer 106(1):1-7. PubMed: 12794750MGI: J:84004
- Emtage PC; Wan Y; Hitt M; Graham FL; Muller WJ; Zlotnik A; Gauldie J. 1999. Adenoviral vectors expressing lymphotactin and interleukin 2 or lymphotactin and interleukin 12 synergize to facilitate tumor regression in murine breast cancer models [see comments] Hum Gene Ther 10(5):697-709. PubMed: 10210138MGI: J:54403
- Esteva-Font C; Jin BJ; Verkman AS. 2014. Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT mice. FASEB J 28(3):1446-53. PubMed: 24334548MGI: J:210686
- Eubank TD ; Roberts RD ; Khan M ; Curry JM ; Nuovo GJ ; Kuppusamy P ; Marsh CB. 2009. Granulocyte macrophage colony-stimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages. Cancer Res 69(5):2133-40. PubMed: 19223554MGI: J:146607
- Eyob H; Ekiz HA; Derose YS; Waltz SE; Williams MA; Welm AL. 2013. Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity. Cancer Discov 3(7):751-60. PubMed: 23612011MGI: J:203569
- Fabris VT. 2014. From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer. Cancer Genet 207(6):233-46. PubMed: 25176624MGI: J:214799
- Fan H; Zhao X; Sun S; Luo M; Guan JL. 2013. Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo. J Biol Chem 288(5):3322-33. PubMed: 23255596MGI: J:195658
- Fantozzi A; Christofori G. 2006. Mouse models of breast cancer metastasis. Breast Cancer Res 8(4):212. PubMed: 16887003MGI: J:116013
- Faraji F; Hu Y; Wu G; Goldberger NE; Walker RC; Zhang J; Hunter KW. 2014. An integrated systems genetics screen reveals the transcriptional structure of inherited predisposition to metastatic disease. Genome Res 24(2):227-40. PubMed: 24322557MGI: J:216038
- Feeley KP; Bray AW; Westbrook DG; Johnson LW; Kesterson RA; Ballinger SW; Welch DR. 2015. Mitochondrial Genetics Regulate Breast Cancer Tumorigenicity and Metastatic Potential. Cancer Res 75(20):4429-36. PubMed: 26471915MGI: J:226009
- Fend L; Accart N; Kintz J; Cochin S; Reymann C; Le Pogam F; Marchand JB; Menguy T; Slos P; Rooke R; Fournel S; Bonnefoy JY; Preville X; Haegel H. 2013. Therapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclasts. PLoS One 8(9):e73310. PubMed: 24019914MGI: J:206408
- Fierz Y; Novosyadlyy R; Vijayakumar A; Yakar S; LeRoith D. 2010. Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression. Diabetes 59(3):686-93. PubMed: 19959755MGI: J:164155
- Flowers M; Schroeder JA; Borowsky AD; Besselsen DG; Thomson CA; Pandey R; Thompson PA. 2010. Pilot study on the effects of dietary conjugated linoleic acid on tumorigenesis and gene expression in PyMT transgenic mice. Carcinogenesis 31(9):1642-9. PubMed: 20624750MGI: J:163639
- Forrester E; Chytil A; Bierie B; Aakre M; Gorska AE; Sharif-Afshar AR; Muller WJ; Moses HL. 2005. Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Cancer Res 65(6):2296-302. PubMed: 15781643MGI: J:97162
- Franci C; Zhou J; Jiang Z; Modrusan Z; Good Z; Jackson E; Kouros-Mehr H. 2013. Biomarkers of residual disease, disseminated tumor cells, and metastases in the MMTV-PyMT breast cancer model. PLoS One 8(3):e58183. PubMed: 23520493MGI: J:199913
- Francis SM; Chakrabarti S; Dick FA. 2011. A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis. PLoS One 6(2):e16434. PubMed: 21364977MGI: J:171066
- Frohlich C; Nehammer C; Albrechtsen R; Kronqvist P; Kveiborg M; Sehara-Fujisawa A; Mercurio AM; Wewer UM. 2011. ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression. Mol Cancer Res 9(11):1449-61. PubMed: 21875931MGI: J:205399
- Gallego-Ortega D; Ledger A; Roden DL; Law AM; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AI; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JR; Rabinovich B; Millar EK; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O'Toole S; Green AR; Timpson P; Gee JM; Ellis IO; Clark SJ; Ormandy CJ. 2015. ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells. PLoS Biol 13(12):e1002330. PubMed: 26717410MGI: J:230031
- Gao D; Joshi N; Choi H; Ryu S; Hahn M; Catena R; Sadik H; Argani P; Wagner P; Vahdat LT; Port JL; Stiles B; Sukumar S; Altorki NK; Rafii S; Mittal V. 2012. Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition. Cancer Res 72(6):1384-94. PubMed: 22282653MGI: J:184945
- Garmy-Susini B; Avraamides CJ; Schmid MC; Foubert P; Ellies LG; Barnes L; Feral C; Papayannopoulou T; Lowy A; Blair SL; Cheresh D; Ginsberg M; Varner JA. 2010. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res 70(8):3042-51. PubMed: 20388801MGI: J:158943
- Ghosh SK; Uchida M; Yoo B; Ross AW; Gendler SJ; Gong J; Moore A; Medarova Z. 2013. Targeted imaging of breast tumor progression and therapeutic response in a human uMUC-1 expressing transgenic mouse model. Int J Cancer 132(8):1860-7. PubMed: 23015160MGI: J:193507
- Gocheva V; Wang HW; Gadea BB; Shree T; Hunter KE; Garfall AL; Berman T; Joyce JA. 2010. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev 24(3):241-55. PubMed: 20080943MGI: J:156936
- Goel S; Gupta N; Walcott BP; Snuderl M; Kesler CT; Kirkpatrick ND; Heishi T; Huang Y; Martin JD; Ager E; Samuel R; Wang S; Yazbek J; Vakoc BJ; Peterson RT; Padera TP; Duda DG; Fukumura D; Jain RK. 2013. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. J Natl Cancer Inst 105(16):1188-201. PubMed: 23899555MGI: J:202527
- Goh J; Tsai J; Bammler TK; Farin FM; Endicott E; Ladiges WC. 2013. Exercise training in transgenic mice is associated with attenuation of early breast cancer growth in a dose-dependent manner. PLoS One 8(11):e80123. PubMed: 24312199MGI: J:209759
- Goldberger N; Walker RC; Kim CH; Winter S; Hunter KW. 2013. Inherited variation in miR-290 expression suppresses breast cancer progression by targeting the metastasis susceptibility gene Arid4b. Cancer Res 73(8):2671-81. PubMed: 23447578MGI: J:197056
- Gordon RR; Hunter KW; La Merrill M; Sorensen P; Threadgill DW; Pomp D. 2008. Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis. Mamm Genome 19(3):179-89. PubMed: 18288525MGI: J:136011
- Gordon RR; Hunter KW; Sorensen P; Pomp D. 2008. Genotype x diet interactions in mice predisposed to mammary cancer. I. Body weight and fat. Mamm Genome 19(3):163-78. PubMed: 18286334MGI: J:132804
- Graham RA; Morris JR; Cohen EP; Taylor-Papadimitriou J. 2001. Up-regulation of MUC1 in mammary tumors generated in a double-transgenic mouse expressing human MUC1 cDNA, under the control of 1.4-kb 5' MUC1 promoter sequence and the middle T oncogene, expressed from the MMTV promoter. Int J Cancer 92(3):382-7. PubMed: 11291075MGI: J:68466
- Granovsky M; Fata J; Pawling J; Muller WJ; Khokha R; Dennis JW. 2000. Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nat Med 6(3):306-12. PubMed: 10700233MGI: J:60960
- Grum-Schwensen B; Klingelhofer J; Grigorian M; Almholt K; Nielsen BS; Lukanidin E; Ambartsumian N. 2010. Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. Cancer Res 70(3):936-47. PubMed: 20103644MGI: J:156859
- Guillory B; Sakwe AM; Saria M; Thompson P; Adhiambo C; Koumangoye R; Ballard B; Binhazim A; Cone C; Jahanen-Dechent W; Ochieng J. 2010. Lack of fetuin-A (alpha2-HS-glycoprotein) reduces mammary tumor incidence and prolongs tumor latency via the transforming growth factor-beta signaling pathway in a mouse model of breast cancer. Am J Pathol 177(5):2635-44. PubMed: 20847285MGI: J:166263
- Guy CT; Muthuswamy SK; Cardiff RD; Soriano P; Muller WJ. 1994. Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev 8(1):23-32. PubMed: 7507074MGI: J:72125
- Ha NH; Long J; Cai Q; Shu XO; Hunter KW. 2016. The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer. PLoS Genet 12(9):e1006267. PubMed: 27656887MGI: J:235645
- Hakem A; Sanchez-Sweatman O; You-Ten A; Duncan G; Wakeham A; Khokha R; Mak TW. 2005. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev 19(17):1974-9. PubMed: 16107613MGI: J:100482
- Hariri M; Wood GA; DiGrappa MA; MacPherson M; Backman SA; Yaffe MJ; Mak TW; Boyd NF; Khokha R. 2004. Experimental manipulation of radiographic density in mouse mammary gland. Breast Cancer Res 6(5):R540-5. PubMed: 15318935MGI: J:92894
- Harney AS; Arwert EN; Entenberg D; Wang Y; Guo P; Qian BZ; Oktay MH; Pollard JW; Jones JG; Condeelis JS. 2015. Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA. Cancer Discov 5(9):932-43. PubMed: 26269515MGI: J:230601
- Hassan S; Buchanan M; Jahan K; Aguilar-Mahecha A; Gaboury L; Muller WJ; Alsawafi Y; Mourskaia AA; Siegel PM; Salvucci O; Basik M. 2011. CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int J Cancer 129(1):225-32. PubMed: 20830712MGI: J:173812
- Hebbard L; Cecena G; Golas J; Sawada J; Ellies LG; Charbono A; Williams R; Jimenez RE; Wankell M; Arndt KT; DeJoy SQ; Rollins RA; Diesl V; Follettie M; Chen L; Rosfjord E; Cardiff RD; Komatsu M; Boschelli F; Oshima RG. 2011. Control of mammary tumor differentiation by SKI-606 (bosutinib). Oncogene 30(3):301-12. PubMed: 20818417MGI: J:168815
- Hebbard LW; Garlatti M; Young LJ; Cardiff RD; Oshima RG; Ranscht B. 2008. T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. Cancer Res 68(5):1407-16. PubMed: 18316604MGI: J:132759
- Hedlund M; Ng E; Varki A; Varki NM. 2008. alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo. Cancer Res 68(2):388-94. PubMed: 18199532MGI: J:131420
- Herschkowitz JI; Simin K; Weigman VJ; Mikaelian I; Usary J; Hu Z; Rasmussen KE; Jones LP; Assefnia S; Chandrasekharan S; Backlund MG; Yin Y; Khramtsov AI; Bastein R; Quackenbush J; Glazer RI; Brown PH; Green JE; Kopelovich L; Furth PA; Palazzo JP; Olopade OI; Bernard PS; Churchill GA; Van Dyke T; Perou CM. 2007. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 8(5):R76. PubMed: 17493263MGI: J:160877
- Hodgson JG; Malek T; Bornstein S; Hariono S; Ginzinger DG; Muller WJ; Gray JW. 2005. Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling. Cancer Res 65(21):9695-704. PubMed: 16266989MGI: J:102690
- Hollern DP; Andrechek ER. 2014. A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer Breast Cancer Res 16:R59. MGI: J:210803
- Hollern DP; Honeysett J; Cardiff RD; Andrechek ER. 2014. The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer. Mol Cell Biol 34(17):3229-43. PubMed: 24934442MGI: J:224271
- Hu Y; Bai L; Geiger T; Goldberger N; Walker RC; Green JE; Wakefield LM; Hunter KW. 2013. Genetic background may contribute to PAM50 gene expression breast cancer subtype assignments. PLoS One 8(8):e72287. PubMed: 24015230MGI: J:205937
- Hu Y; Wu G; Rusch M; Lukes L; Buetow KH; Zhang J; Hunter KW. 2012. Integrated cross-species transcriptional network analysis of metastatic susceptibility. Proc Natl Acad Sci U S A 109(8):3184-9. PubMed: 22308418MGI: J:216039
- Huang Y; Yuan J; Righi E; Kamoun WS; Ancukiewicz M; Nezivar J; Santosuosso M; Martin JD; Martin MR; Vianello F; Leblanc P; Munn LL; Huang P; Duda DG; Fukumura D; Jain RK; Poznansky MC. 2012. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A 109(43):17561-6. PubMed: 23045683MGI: J:190374
- Hulit J; Suyama K; Chung S; Keren R; Agiostratidou G; Shan W; Dong X; Williams TM; Lisanti MP; Knudsen K; Hazan RB. 2007. N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation. Cancer Res 67(7):3106-16. PubMed: 17409417MGI: J:120832
- Hunter KW; Broman KW; Voyer TL; Lukes L; Cozma D; Debies MT; Rouse J; Welch DR. 2001. Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1. Cancer Res 61(24):8866-72. PubMed: 11751410MGI: J:73358
- Husemann Y; Geigl JB; Schubert F; Musiani P; Meyer M; Burghart E; Forni G; Eils R; Fehm T; Riethmuller G; Klein CA. 2008. Systemic spread is an early step in breast cancer. Cancer Cell 13(1):58-68. PubMed: 18167340MGI: J:131063
- Iyengar P; Espina V; Williams TW; Lin Y; Berry D; Jelicks LA; Lee H; Temple K; Graves R; Pollard J; Chopra N; Russell RG; Sasisekharan R; Trock BJ; Lippman M; Calvert VS; Petricoin EF; Liotta L; Dadachova E; Pestell RG; Lisanti MP; Bonaldo P; Scherer PE. 2005. Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J Clin Invest 115(5):1163-1176. PubMed: 15841211MGI: J:98091
- Izumchenko E; Singh MK; Plotnikova OV; Tikhmyanova N; Little JL; Serebriiskii IG; Seo S; Kurokawa M; Egleston BL; Klein-Szanto A; Pugacheva EN; Hardy RR; Wolfson M; Connolly DC; Golemis EA. 2009. NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res 69(18):7198-206. PubMed: 19738060MGI: J:152685
- Jackson HW; Hojilla CV; Weiss A; Sanchez OH; Wood GA; Khokha R. 2015. Timp3 deficient mice show resistance to developing breast cancer. PLoS One 10(3):e0120107. PubMed: 25807548MGI: J:229619
- Jaskelioff M; Song W; Xia J; Liu C; Kramer J; Koido S; Gendler SJ; Calderwood SK; Gong J. 2009. Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogene. Oncogene 28(48):4225-36. PubMed: 19734944MGI: J:157042
- Jing H; Hu J; He B; Negron Abril YL; Stupinski J; Weiser K; Carbonaro M; Chiang YL; Southard T; Giannakakou P; Weiss RS; Lin H. 2016. A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer Cell 29(5):767-768. PubMed: 27165747MGI: J:231891
- Johansson J; Berg T; Kurzejamska E; Pang MF; Tabor V; Jansson M; Roswall P; Pietras K; Sund M; Religa P; Fuxe J. 2013. MiR-155-mediated loss of C/EBPbeta shifts the TGF-beta response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer. Oncogene 32(50):5614-24. PubMed: 23955085MGI: J:205160
- Kazerounian S; Gerald D; Huang M; Chin YR; Udayakumar D; Zheng N; O'Donnell RK; Perruzzi C; Mangiante L; Pourat J; Phung TL; Bravo-Nuevo A; Shechter S; McNamara S; Duhadaway JB; Kocher ON; Brown LF; Toker A; Prendergast GC; Benjamin LE. 2013. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Res 73(1):50-61. PubMed: 23135917MGI: J:194113
- Kelly-Spratt KS; Pitteri SJ; Gurley KE; Liggitt D; Chin A; Kennedy J; Wong CH; Zhang Q; Buson TB; Wang H; Hanash SM; Kemp CJ. 2011. Plasma proteome profiles associated with inflammation, angiogenesis, and cancer. PLoS One 6(5):e19721. PubMed: 21589862MGI: J:172643
- Khattar E; Kumar P; Liu CY; Akincilar SC; Raju A; Lakshmanan M; Maury JJ; Qiang Y; Li S; Tan EY; Hui KM; Shi M; Loh YH; Tergaonkar V. 2016. Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression. J Clin Invest 126(10):4045-4060. PubMed: 27643433MGI: J:237368
- Kim C; Yang H; Fukushima Y; Saw PE; Lee J; Park JS; Park I; Jung J; Kataoka H; Lee D; Heo WD; Kim I; Jon S; Adams RH; Nishikawa S; Uemura A; Koh GY. 2014. Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. Cancer Cell 25(1):102-17. PubMed: 24434213MGI: J:208154
- Kim IS; Baek SH. 2010. Mouse models for breast cancer metastasis. Biochem Biophys Res Commun 394(3):443-7. PubMed: 20230796MGI: J:159230
- Kim JW; Evans C; Weidemann A; Takeda N; Lee YS; Stockmann C; Branco-Price C; Brandberg F; Leone G; Ostrowski MC; Johnson RS. 2012. Loss of fibroblast HIF-1alpha accelerates tumorigenesis. Cancer Res 72(13):3187-95. PubMed: 22556263MGI: J:189318
- Kim W; Takyar FM; Swan K; Jeong J; VanHouten J; Sullivan C; Dann P; Yu H; Fiaschi-Taesch N; Chang W; Wysolmerski J. 2016. Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein. Cancer Res 76(18):5348-60. PubMed: 27450451MGI: J:235135
- Koh YJ; Kim HZ; Hwang SI; Lee JE; Oh N; Jung K; Kim M; Kim KE; Kim H; Lim NK; Jeon CJ; Lee GM; Jeon BH; Nam DH; Sung HK; Nagy A; Yoo OJ; Koh GY. 2010. Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage. Cancer Cell 18(2):171-84. PubMed: 20708158MGI: J:163671
- Kouros-Mehr H; Bechis SK; Slorach EM; Littlepage LE; Egeblad M; Ewald AJ; Pai SY; Ho IC; Werb Z. 2008. GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell 13(2):141-52. PubMed: 18242514MGI: J:131913
- Kuch V; Schreiber C; Thiele W; Umansky V; Sleeman JP. 2013. Tumor-initiating properties of breast cancer and melanoma cells in vivo are not invariably reflected by spheroid formation in vitro, but can be increased by long-term culturing as adherent monolayers. Int J Cancer 132(3):E94-105. PubMed: 22907275MGI: J:193510
- Kuchnio A; Moens S; Bruning U; Kuchnio K; Cruys B; Thienpont B; Broux M; Ungureanu AA; Leite de Oliveira R; Bruyere F; Cuervo H; Manderveld A; Carton A; Hernandez-Fernaud JR; Zanivan S; Bartic C; Foidart JM; Noel A; Vinckier S; Lambrechts D; Dewerchin M; Mazzone M; Carmeliet P. 2015. The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts. Cell Rep 12(6):992-1005. PubMed: 26235614MGI: J:227777
- Kupferman ME; Fini ME; Muller WJ; Weber R; Cheng Y; Muschel RJ. 2000. Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression Am J Pathol 157(6):1777-83. PubMed: 11106549MGI: J:66129
- Kurpios NA; Sabolic NA; Shepherd TG; Fidalgo GM; Hassell JA. 2003. Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis. J Mammary Gland Biol Neoplasia 8(2):177-90. PubMed: 14635793MGI: J:87017
- La Merrill M; Baston DS; Denison MS; Birnbaum LS; Pomp D; Threadgill DW. 2009. Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. Am J Physiol Endocrinol Metab 296(1):E203-10. PubMed: 18840765MGI: J:145631
- Lahlou H; Sanguin-Gendreau V; Frame MC; Muller WJ. 2012. Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo. Breast Cancer Res 14(1):R36. PubMed: 22373082MGI: J:231722
- Lahlou H; Sanguin-Gendreau V; Zuo D; Cardiff RD; McLean GW; Frame MC; Muller WJ. 2007. Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A 104(51):20302-7. PubMed: 18056629MGI: J:141541
- Lam JB; Chow KH; Xu A; Lam KS; Liu J; Wong NS; Moon RT; Shepherd PR; Cooper GJ; Wang Y. 2009. Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. PLoS One 4(3):e4968. PubMed: 19319191MGI: J:147458
- Lan L; Holland JD; Qi J; Grosskopf S; Vogel R; Gyorffy B; Wulf-Goldenberg A; Birchmeier W. 2015. Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice. EMBO J 34(11):1493-508. PubMed: 25736378MGI: J:222985
- Lancaster M; Rouse J; Hunter KW. 2005. Modifiers of mammary tumor progression and metastasis on mouse chromosomes 7, 9, and 17. Mamm Genome 16(2):120-6. PubMed: 15859357MGI: J:97671
- Le Voyer T; Lu Z; Babb J; Lifsted T; Williams M; Hunter K. 2000. An epistatic interaction controls the latency of a transgene-induced mammary tumor. Mamm Genome 11(10):883-9. PubMed: 11003704MGI: J:64663
- Le Voyer T; Rouse J; Lu Z; Lifsted T; Williams M; Hunter KW. 2001. Three loci modify growth of a transgene-induced mammary tumor: suppression of proliferation associated with decreased microvessel density. Genomics 74(3):253-61. PubMed: 11414753MGI: J:70229
- Leal AS; Sporn MB; Pioli PA; Liby KT. 2016. The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer. Carcinogenesis 37(12):1170-1179. PubMed: 27659181MGI: J:237851
- Lee IH; Sohn M; Lim HJ; Yoon S; Oh H; Shin S; Shin JH; Oh SH; Kim J; Lee DK; Noh DY; Bae DS; Seong JK; Bae YS. 2014. Ahnak functions as a tumor suppressor via modulation of TGFbeta/Smad signaling pathway. Oncogene 33(38):4675-84. PubMed: 24662814MGI: J:214424
- Ley S; Weigert A; Weichand B; Henke N; Mille-Baker B; Janssen RA; Brune B. 2013. The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages. Oncogene 32(5):631-40. PubMed: 22410777MGI: J:193372
- Li J; Luco AL; Ochietti B; Fadhil I; Camirand A; Reinhardt TA; St-Arnaud R; Muller W; Kremer R. 2016. Tumoral Vitamin D Synthesis by CYP27B1 1-alpha-Hydroxylase Delays Mammary Tumor Progression in the PyMT-MMTV Mouse Model and Its Action Involves NF-kappaB Modulation. Endocrinology 157(6):2204-16. PubMed: 27119753MGI: J:235383
- Li L; Hanahan D. 2013. Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion. Cell 153(1):86-100. PubMed: 23540692MGI: J:197249
- Li SH; Hawthorne VS; Neal CL; Sanghera S; Xu J; Yang J; Guo H; Steeg PS; Yu D. 2009. Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activation. Cancer Res 69(24):9163-8. PubMed: 19951994MGI: J:155393
- Li Y; Welm B; Podsypanina K; Huang S; Chamorro M; Zhang X; Rowlands T; Egeblad M; Cowin P; Werb Z; Tan LK; Rosen JM; Varmus HE. 2003. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A 100(26):15853-8. PubMed: 14668450MGI: J:87520
- Lifsted T; Le Voyer T; Williams M; Muller W; Klein-Szanto A; Buetow KH ; Hunter KW. 1998. Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int J Cancer 77(4):640-4. PubMed: 9679770MGI: J:48854
- Lin EY; Jones JG; Li P; Zhu L; Whitney KD; Muller WJ; Pollard JW. 2003. Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 163(5):2113-26. PubMed: 14578209MGI: J:86499
- Lin EY; Li JF; Gnatovskiy L; Deng Y; Zhu L; Grzesik DA; Qian H; Xue XN; Pollard JW. 2006. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res 66(23):11238-46. PubMed: 17114237MGI: J:116132
- Lin EY; Pollard JW. 2004. Macrophages: modulators of breast cancer progression. Novartis Found Symp 256:158-68; discussion 168-72, 259. PubMed: 15027489MGI: J:90229
- Lin FJ; Chen X; Qin J; Hong YK; Tsai MJ; Tsai SY. 2010. Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development. J Clin Invest 120(5):1694-707. PubMed: 20364082MGI: J:161485
- Liu K; Caldwell SA; Abrams SI. 2005. Cooperative disengagement of Fas and intercellular adhesion molecule-1 function in neoplastic cells confers enhanced colonization efficiency. Cancer Res 65(3):1045-54. PubMed: 15705906MGI: J:96563
- Lopez JI; Camenisch TD; Stevens MV; Sands BJ; McDonald J; Schroeder JA. 2005. CD44 attenuates metastatic invasion during breast cancer progression. Cancer Res 65(15):6755-63. PubMed: 16061657MGI: J:100774
- Lukes L; Crawford NP; Walker R; Hunter KW. 2009. The origins of breast cancer prognostic gene expression profiles. Cancer Res 69(1):310-8. PubMed: 19118016MGI: J:143027
- Luo M; Fan H; Nagy T; Wei H; Wang C; Liu S; Wicha MS; Guan JL. 2009. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res 69(2):466-74. PubMed: 19147559MGI: J:143710
- Luo M; Zhao X; Chen S; Liu S; Wicha MS; Guan JL. 2013. Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer Res 73(17):5591-602. PubMed: 23832665MGI: J:201836
- Ma Z; Gibson SL; Byrne MA; Zhang J; White MF; Shaw LM. 2006. Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Mol Cell Biol 26(24):9338-51. PubMed: 17030605MGI: J:117024
- Maglione JE; Moghanaki D; Young LJ; Manner CK; Ellies LG; Joseph SO; Nicholson B; Cardiff RD; MacLeod CL. 2001. Transgenic Polyoma middle-T mice model premalignant mammary disease. Cancer Res 61(22):8298-305. PubMed: 11719463MGI: J:72996
- Man AK; Young LJ; Tynan JA; Lesperance J; Egeblad M; Werb Z; Hauser CA; Muller WJ; Cardiff RD; Oshima RG. 2003. Ets2-dependent stromal regulation of mouse mammary tumors. Mol Cell Biol 23(23):8614-25. PubMed: 14612405MGI: J:86530
- Mardilovich K; Shaw LM. 2009. Hypoxia regulates insulin receptor substrate-2 expression to promote breast carcinoma cell survival and invasion. Cancer Res 69(23):8894-901. PubMed: 19920186MGI: J:155053
- Marjon NA; Hu C; Hathaway HJ; Prossnitz ER. 2014. G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis. Mol Cancer Res 12(11):1644-54. PubMed: 25030371MGI: J:216705
- Maroulakou IG; Oemler W; Naber SP; Tsichlis PN. 2007. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res 67(1):167-77. PubMed: 17210696MGI: J:117336
- Martin MD; Carter KJ; Jean-Philippe SR; Chang M; Mobashery S; Thiolloy S; Lynch CC; Matrisian LM; Fingleton B. 2008. Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res 68(15):6251-9. PubMed: 18676849MGI: J:140033
- McCartan D; Bolger JC; Fagan A; Byrne C; Hao Y; Qin L; McIlroy M; Xu J; Hill AD; Gaora PO; Young LS. 2012. Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer. Cancer Res 72(1):220-9. PubMed: 22072566MGI: J:181041
- Moadel RM; Nguyen AV; Lin EY; Lu P; Mani J; Blaufox MD; Pollard JW; Dadachova E. 2003. Positron emission tomography agent 2-deoxy-2-[18F]fluoro-D-glucose has a therapeutic potential in breast cancer. Breast Cancer Res 5(6):R199-205. PubMed: 14580255MGI: J:86497
- Mouw JK; Yui Y; Damiano L; Bainer RO; Lakins JN; Acerbi I; Ou G; Wijekoon AC; Levental KR; Gilbert PM; Hwang ES; Chen YY; Weaver VM. 2014. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nat Med 20(4):360-7. PubMed: 24633304MGI: J:210315
- Murakami M; Giampietro C; Giannotta M; Corada M; Torselli I; Orsenigo F; Cocito A; d'Ario G; Mazzarol G; Confalonieri S; Di Fiore PP; Dejana E. 2011. Abrogation of junctional adhesion molecule-a expression induces cell apoptosis and reduces breast cancer progression. PLoS One 6(6):e21242. PubMed: 21695058MGI: J:174294
- Muraoka RS; Dumont N; Ritter CA; Dugger TC; Brantley DM; Chen J; Easterly E; Roebuck LR; Ryan S; Gotwals PJ; Koteliansky V; Arteaga CL. 2002. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest 109(12):1551-9. PubMed: 12070302MGI: J:86709
- Nagle JA; Ma Z; Byrne MA; White MF; Shaw LM. 2004. Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Mol Cell Biol 24(22):9726-35. PubMed: 15509777MGI: J:94107
- Nasr Z; Robert F; Porco JA Jr; Muller WJ; Pelletier J. 2013. eIF4F suppression in breast cancer affects maintenance and progression. Oncogene 32(7):861-71. PubMed: 22484424MGI: J:193363
- Navarro P; Bueno MJ; Zagorac I; Mondejar T; Sanchez J; Mouron S; Munoz J; Gomez-Lopez G; Jimenez-Renard V; Mulero F; Chandel NS; Quintela-Fandino M. 2016. Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics. Cell Rep 15(12):2705-18. PubMed: 27292634MGI: J:238303
- Neznanov N; Man AK; Yamamoto H; Hauser CA; Cardiff RD; Oshima RG. 1999. A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice. Cancer Res 59(17):4242-6. PubMed: 10485465MGI: J:57272
- Nguyen A; Burack WR; Stock JL; Kortum R; Chaika OV; Afkarian M; Muller WJ; Murphy KM; Morrison DK; Lewis RE; McNeish J; Shaw AS. 2002. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol 22(9):3035-45. PubMed: 11940661MGI: J:75739
- Ni T; Li XY; Lu N; An T; Liu ZP; Fu R; Lv WC; Zhang YW; Xu XJ; Grant Rowe R; Lin YS; Scherer A; Feinberg T; Zheng XQ; Chen BA; Liu XS; Guo QL; Wu ZQ; Weiss SJ. 2016. Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Nat Cell Biol 18(11):1221-1232. PubMed: 27749822MGI: J:238557
- Niemeyer CC; Spencer-Dene B; Wu JX; Adamson ED. 1999. Preneoplastic mammary tumor markers: Cripto and Amphiregulin are overexpressed in hyperplastic stages of tumor progression in transgenic mice. Int J Cancer 81(4):588-91. PubMed: 10225449MGI: J:54862
- Nobrega-Pereira S; Fernandez-Marcos PJ; Brioche T; Gomez-Cabrera MC; Salvador-Pascual A; Flores JM; Vina J; Serrano M. 2016. G6PD protects from oxidative damage and improves healthspan in mice. Nat Commun 7:10894. PubMed: 26976705MGI: J:236755
- Novitskiy SV; Pickup MW; Gorska AE; Owens P; Chytil A; Aakre M; Wu H; Shyr Y; Moses HL. 2011. TGF-beta receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms. Cancer Discov 1(5):430-41. PubMed: 22408746MGI: J:185747
- Novosyadlyy R; Lann DE; Vijayakumar A; Rowzee A; Lazzarino DA; Fierz Y; Carboni JM; Gottardis MM; Pennisi PA; Molinolo AA; Kurshan N; Mejia W; Santopietro S; Yakar S; Wood TL; LeRoith D. 2010. Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes. Cancer Res 70(2):741-51. PubMed: 20068149MGI: J:156752
- O'Donnell RK; Falcon B; Hanson J; Goldstein WE; Perruzzi C; Rafii S; Aird WC; Benjamin LE. 2016. VEGF-A/VEGFR Inhibition Restores Hematopoietic Homeostasis in the Bone Marrow and Attenuates Tumor Growth. Cancer Res 76(3):517-24. PubMed: 26719538MGI: J:230508
- Oghumu S; Varikuti S; Terrazas C; Kotov D; Nasser MW; Powell CA; Ganju RK; Satoskar AR. 2014. CXCR3 deficiency enhances tumor progression by promoting macrophage M2 polarization in a murine breast cancer model. Immunology 143(1):109-19. PubMed: 24679047MGI: J:219472
- Ojalvo LS; King W; Cox D; Pollard JW. 2009. High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors. Am J Pathol 174(3):1048-64. PubMed: 19218341MGI: J:146811
- Ojalvo LS; Whittaker CA; Condeelis JS; Pollard JW. 2010. Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol 184(2):702-12. PubMed: 20018620MGI: J:159401
- Ooms LM; Binge LC; Davies EM; Rahman P; Conway JR; Gurung R; Ferguson DT; Papa A; Fedele CG; Vieusseux JL; Chai RC; Koentgen F; Price JT; Tiganis T; Timpson P; McLean CA; Mitchell CA. 2015. The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis. Cancer Cell 28(2):155-69. PubMed: 26267533MGI: J:224914
- Oren B; Urosevic J; Mertens C; Mora J; Guiu M; Gomis RR; Weigert A; Schmid T; Grein S; Brune B; Jung M. 2016. Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis. J Pathol 239(3):274-85. PubMed: 27038000MGI: J:241176
- Owens TW; Rogers RL; Best SA; Ledger A; Mooney AM; Ferguson A; Shore P; Swarbrick A; Ormandy CJ; Simpson PT; Carroll JS; Visvader JE; Naylor MJ. 2014. Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer. Cancer Res 74(18):5277-86. PubMed: 25056120MGI: J:215993
- Pakala SB; Rayala SK; Wang RA; Ohshiro K; Mudvari P; Reddy SD; Zheng Y; Pires R; Casimiro S; Pillai MR; Costa L; Kumar R. 2013. MTA1 Promotes STAT3 Transcription and Pulmonary Metastasis in Breast Cancer. Cancer Res 73(12):3761-3770. PubMed: 23580571MGI: J:198473
- Park JS; Kim IK; Han S; Park I; Kim C; Bae J; Oh SJ; Lee S; Kim JH; Woo DC; He Y; Augustin HG; Kim I; Lee D; Koh GY. 2016. Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment. Cancer Cell 30(6):953-967. PubMed: 27960088MGI: J:238058
- Partridge EA; Le Roy C; Di Guglielmo GM; Pawling J; Cheung P; Granovsky M; Nabi IR; Wrana JL; Dennis JW. 2004. Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306(5693):120-4. PubMed: 15459394MGI: J:93100
- Patsialou A; Wyckoff J; Wang Y; Goswami S; Stanley ER; Condeelis JS. 2009. Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res 69(24):9498-506. PubMed: 19934330MGI: J:155533
- Peace BE; Toney-Earley K; Collins MH; Waltz SE. 2005. Ron receptor signaling augments mammary tumor formation and metastasis in a murine model of breast cancer. Cancer Res 65(4):1285-93. PubMed: 15735014MGI: J:96786
- Pedersen TX; Pennington CJ; Almholt K; Christensen IJ; Nielsen BS; Edwards DR; Romer J; Dano K; Johnsen M. 2005. Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas. Carcinogenesis 26(7):1233-40. PubMed: 15760918MGI: J:99389
- Pickup MW; Laklai H; Acerbi I; Owens P; Gorska AE; Chytil A; Aakre M; Weaver VM; Moses HL. 2013. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-beta-deficient mouse mammary carcinomas. Cancer Res 73(17):5336-46. PubMed: 23856251MGI: J:202531
- Politi K; Kljuic A; Szabolcs M; Fisher P; Ludwig T; Efstratiadis A. 2004. 'Designer' tumors in mice. Oncogene 23(8):1558-65. PubMed: 14661057MGI: J:87544
- Provenzano PP; Inman DR; Eliceiri KW; Beggs HE; Keely PJ. 2008. Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol 173(5):1551-65. PubMed: 18845837MGI: J:141117
- Pylayeva Y; Gillen KM; Gerald W; Beggs HE; Reichardt LF; Giancotti FG. 2009. Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest 119(2):252-66. PubMed: 19147981MGI: J:145974
- Qian B; Deng Y; Im JH; Muschel RJ; Zou Y; Li J; Lang RA; Pollard JW. 2009. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One 4(8):e6562. PubMed: 19668347MGI: J:152473
- Qian BZ; Li J; Zhang H; Kitamura T; Zhang J; Campion LR; Kaiser EA; Snyder LA; Pollard JW. 2011. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475(7355):222-5. PubMed: 21654748MGI: J:186831
- Qian BZ; Zhang H; Li J; He T; Yeo EJ; Soong DY; Carragher NO; Munro A; Chang A; Bresnick AR; Lang RA; Pollard JW. 2015. FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. J Exp Med 212(9):1433-48. PubMed: 26261265MGI: J:227135
- Qian X; Hulit J; Suyama K; Eugenin EA; Belbin TJ; Loudig O; Smirnova T; Zhou ZN; Segall J; Locker J; Phillips GR; Norton L; Hazan RB. 2013. p21CIP1 mediates reciprocal switching between proliferation and invasion during metastasis. Oncogene 32(18):2292-303, 2303.e1-7. PubMed: 22751124MGI: J:198021
- Qian X; Li G; Vass WC; Papageorge A; Walker RC; Asnaghi L; Steinbach PJ; Tosato G; Hunter K; Lowy DR. 2009. The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis. Cancer Cell 16(3):246-58. PubMed: 19732724MGI: J:152691
- Qin J; Chen X; Xie X; Tsai MJ; Tsai SY. 2010. COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis. Proc Natl Acad Sci U S A 107(8):3687-92. PubMed: 20133706MGI: J:157554
- Qin L; Liao L; Redmond A; Young L; Yuan Y; Chen H; O'Malley BW; Xu J. 2008. The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression. Mol Cell Biol 28(19):5937-50. PubMed: 18644862MGI: J:140358
- Qin L; Liu Z; Chen H; Xu J. 2009. The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis. Cancer Res 69(9):3819-27. PubMed: 19383905MGI: J:148269
- Qiu TH; Chandramouli GV; Hunter KW; Alkharouf NW; Green JE; Liu ET. 2004. Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: correlation to human disease. Cancer Res 64(17):5973-81. PubMed: 15342376MGI: J:92401
- Rauh MJ; Blackmore V; Andrechek ER; Tortorice CG; Daly R; Lai VK; Pawson T; Cardiff RD; Siegel PM; Muller WJ. 1999. Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein. Mol Cell Biol 19(12):8169-79. PubMed: 10567542MGI: J:58608
- Reddy JP; Peddibhotla S; Bu W; Zhao J; Haricharan S; Du YC; Podsypanina K; Rosen JM; Donehower LA; Li Y. 2010. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proc Natl Acad Sci U S A 107(8):3728-33. PubMed: 20133707MGI: J:157553
- Regan Anderson TM; Peacock DL; Daniel AR; Hubbard GK; Lofgren KA; Girard BJ; Schorg A; Hoogewijs D; Wenger RH; Seagroves TN; Lange CA. 2013. Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression. Cancer Res 73(18):5810-20. PubMed: 23928995MGI: J:204358
- Ricciardelli C; Frewin KM; Tan Ide A; Williams ED; Opeskin K; Pritchard MA; Ingman WV; Russell DL. 2011. The ADAMTS1 protease gene is required for mammary tumor growth and metastasis. Am J Pathol 179(6):3075-85. PubMed: 22001177MGI: J:180068
- Richard S; Vogel G; Huot ME; Guo T; Muller WJ; Lukong KE. 2008. Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis. Oncogene 27(4):548-56. PubMed: 17621265MGI: J:132092
- Ritland SR; Rowse GJ; Chang Y; Gendler SJ. 1997. Loss of heterozygosity analysis in primary mammary tumors and lung metastases of MMTV-MTAg and MMTV-neu transgenic mice. Cancer Res 57(16):3520-5. PubMed: 9270023MGI: J:72134
- Robinson GW; Wagner KU; Hennighausen L. 2001. Functional mammary gland development and oncogene-induced tumor formation are not affected by the absence of the retinoblastoma gene. Oncogene 20(48):7115-9. PubMed: 11704837MGI: J:73006
- Rosner A; Miyoshi K; Landesman-Bollag E; Xu X; Seldin DC; Moser AR; MacLeod CL; Shyamala G; Gillgrass AE; Cardiff RD. 2002. Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am J Pathol 161(3):1087-97. PubMed: 12213737MGI: J:78873
- Rubashkin MG; Cassereau L; Bainer R; DuFort CC; Yui Y; Ou G; Paszek MJ; Davidson MW; Chen YY; Weaver VM. 2014. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Res 74(17):4597-611. PubMed: 25183785MGI: J:214798
- Ruffell B; Affara NI; Cottone L; Junankar S; Johansson M; DeNardo DG; Korets L; Reinheckel T; Sloane BF; Bogyo M; Coussens LM. 2013. Cathepsin C is a tissue-specific regulator of squamous carcinogenesis. Genes Dev 27(19):2086-98. PubMed: 24065739MGI: J:202830
- Ryu S; McDonnell K; Choi H; Gao D; Hahn M; Joshi N; Park SM; Catena R; Do Y; Brazin J; Vahdat LT; Silver RB; Mittal V. 2013. Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration. Cancer Cell 23(1):63-76. PubMed: 23328481MGI: J:194343
- Sanders S; Thorgeirsson SS. 2000. Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF-alpha transgenic mice. Mol Carcinog 28(3):168-73. PubMed: 10942533MGI: J:64633
- Sangrar W; Zirgnibl RA; Gao Y; Muller WJ; Jia Z; Greer PA. 2005. An identity crisis for fps/fes: oncogene or tumor suppressor? Cancer Res 65(9):3518-22. PubMed: 15867340MGI: J:98281
- Santidrian AF; Matsuno-Yagi A; Ritland M; Seo BB; LeBoeuf SE; Gay LJ; Yagi T; Felding-Habermann B. 2013. Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest 123(3):1068-81. PubMed: 23426180MGI: J:196392
- Sceneay J; Liu MC; Chen A; Wong CS; Bowtell DD; Moller A. 2013. The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo. PLoS One 8(6):e66388. PubMed: 23840457MGI: J:203723
- Schaffner F; Versteeg HH; Schillert A; Yokota N; Petersen LC; Mueller BM; Ruf W. 2010. Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development. Blood 116(26):6106-13. PubMed: 20861457MGI: J:167394
- Schaffner F; Yokota N; Carneiro-Lobo T; Kitano M; Schaffer M; Anderson GM; Mueller BM; Esmon CT; Ruf W. 2013. Endothelial protein C receptor function in murine and human breast cancer development. PLoS One 8(4):e61071. PubMed: 23593394MGI: J:200026
- Schmid MC; Avraamides CJ; Foubert P; Shaked Y; Kang SW; Kerbel RS; Varner JA. 2011. Combined Blockade of Integrin-alpha4beta1 Plus Cytokines SDF-1alpha or IL-1beta Potently Inhibits Tumor Inflammation and Growth. Cancer Res 71(22):6965-75. PubMed: 21948958MGI: J:178009
- Schmitz J; Schwab J; Schwenck J; Chen Q; Quintanilla-Martinez L; Hahn M; Wietek B; Schwenzer N; Staebler A; Kohlhofer U; Aina OH; Hubbard NE; Reischl G; Borowsky AD; Brucker S; Nikolaou K; la Fougere C; Cardiff RD; Pichler BJ; Schmid AM. 2016. Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study. Cancer Res 76(18):5512-22. PubMed: 27466286MGI: J:235133
- Schoeffner DJ; Matheny SL; Akahane T; Factor V; Berry A; Merlino G; Thorgeirsson UP. 2005. VEGF contributes to mammary tumor growth in transgenic mice through paracrine and autocrine mechanisms. Lab Invest 85(5):608-23. PubMed: 15765121MGI: J:98204
- Schreiber C; Kuch V; Umansky V; Sleeman JP. 2013. Autochthonous mouse melanoma and mammary tumors do not express the pluripotency genes Oct4 and Nanog. PLoS One 8(2):e57465. PubMed: 23468991MGI: J:199393
- Schurigt U; Sevenich L; Vannier C; Gajda M; Schwinde A; Werner F; Stahl A; von Elverfeldt D; Becker AK; Bogyo M; Peters C; Reinheckel T. 2008. Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model. Biol Chem 389(8):1067-74. PubMed: 18710344MGI: J:152448
- Seitzer N; Mayr T; Streit S; Ullrich A. 2010. A single nucleotide change in the mouse genome accelerates breast cancer progression. Cancer Res 70(2):802-12. PubMed: 20068154MGI: J:156750
- Sevenich L; Schurigt U; Sachse K; Gajda M; Werner F; Muller S; Vasiljeva O; Schwinde A; Klemm N; Deussing J; Peters C; Reinheckel T. 2010. Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A 107(6):2497-502. PubMed: 20133781MGI: J:157541
- Sevenich L; Werner F; Gajda M; Schurigt U; Sieber C; Muller S; Follo M; Peters C; Reinheckel T. 2010. Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice. Oncogene :. PubMed: 20818432MGI: J:164578
- Shepard CR; Kassis J; Whaley DL; Kim HG; Wells A. 2007. PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors. Oncogene 26(21):3020-6. PubMed: 17130835MGI: J:122884
- Shishido SN; Delahaye A; Beck A; Nguyen TA. 2014. The anticancer effect of PQ1 in the MMTV-PyVT mouse model. Int J Cancer 134(6):1474-83. PubMed: 24038078MGI: J:211971
- Shishido SN; Faulkner EB; Beck A; Nguyen TA. 2013. The effect of antineoplastic drugs in a male spontaneous mammary tumor model. PLoS One 8(6):e64866. PubMed: 23755153MGI: J:204255
- Shishido SN; Prasain K; Beck A; Nguyen TD; Hua DH; Nguyen TA. 2013. Bioavailability and efficacy of a gap junction enhancer (PQ7) in a mouse mammary tumor model. PLoS One 8(6):e67174. PubMed: 23776708MGI: J:204221
- Singh MK; Izumchenko E; Klein-Szanto AJ; Egleston BL; Wolfson M; Golemis EA. 2010. Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9. Cancer Res 70(21):8907-16. PubMed: 20940402MGI: J:165792
- Song SJ; Poliseno L; Song MS; Ala U; Webster K; Ng C; Beringer G; Brikbak NJ; Yuan X; Cantley LC; Richardson AL; Pandolfi PP. 2013. MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell 154(2):311-24. PubMed: 23830207MGI: J:199994
- Song Y; Aglipay JA; Bernstein JD; Goswami S; Stanley P. 2010. The bisecting GlcNAc on N-glycans inhibits growth factor signaling and retards mammary tumor progression. Cancer Res 70(8):3361-71. PubMed: 20395209MGI: J:158940
- Sounni NE; Dehne K; van Kempen L; Egeblad M; Affara NI; Cuevas I; Wiesen J; Junankar S; Korets L; Lee J; Shen J; Morrison CJ; Overall CM; Krane SM; Werb Z; Boudreau N; Coussens LM. 2010. Stromal regulation of vessel stability by MMP14 and TGF{beta}. Dis Model Mech 3(5-6):317-32. PubMed: 20223936MGI: J:159238
- Spassov DS; Wong CH; Wong SY; Reiter JF; Moasser MM. 2013. Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells. Cancer Res 73(3):1168-79. PubMed: 23243018MGI: J:194368
- Spicer AP; Rowse GJ; Lidner TK; Gendler SJ. 1995. Delayed mammary tumor progression in Muc-1 null mice. J Biol Chem 270(50):30093-101. PubMed: 8530414MGI: J:30128
- Spiotto MT; Banh A; Papandreou I; Cao H; Galvez MG; Gurtner GC; Denko NC; Le QT; Koong AC. 2010. Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth. Cancer Res 70(1):78-88. PubMed: 20028872MGI: J:155736
- Spitzer MH; Carmi Y; Reticker-Flynn NE; Kwek SS; Madhireddy D; Martins MM; Gherardini PF; Prestwood TR; Chabon J; Bendall SC; Fong L; Nolan GP; Engleman EG. 2017. Systemic Immunity Is Required for Effective Cancer Immunotherapy. Cell 168(3):487-502.e15. PubMed: 28111070MGI: J:239513
- Stewart TJ; Abrams SI. 2007. Altered immune function during long-term host-tumor interactions can be modulated to retard autochthonous neoplastic growth. J Immunol 179(5):2851-9. PubMed: 17709499MGI: J:128726
- Stewart TJ; Liewehr DJ; Steinberg SM; Greeneltch KM; Abrams SI. 2009. Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells. J Immunol 183(1):117-28. PubMed: 19542426MGI: J:149980
- Stockmann C; Doedens A; Weidemann A; Zhang N; Takeda N; Greenberg JI; Cheresh DA; Johnson RS. 2008. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 456(7223):814-8. PubMed: 18997773MGI: J:143170
- Sun Y; Zhu X; Chen X; Liu H; Xu Y; Chu Y; Wang G; Liu X. 2014. The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity. Nat Commun 5:5225. PubMed: 25301163MGI: J:241204
- Tao Y; Shen C; Luo S; Traore W; Marchetto S; Santoni MJ; Xu L; Wu B; Shi C; Mei J; Bates R; Liu X; Zhao K; Xiong WC; Borg JP; Mei L. 2014. Role of Erbin in ErbB2-dependent breast tumor growth. Proc Natl Acad Sci U S A 111(42):E4429-38. PubMed: 25288731MGI: J:216431
- Tardaguila M; Mira E; Garcia-Cabezas MA; Feijoo AM; Quintela-Fandino M; Azcoitia I; Lira SA; Manes S. 2013. CX3CL1 Promotes Breast Cancer via Transactivation of the EGF Pathway. Cancer Res 73(14):4461-73. PubMed: 23720051MGI: J:199104
- Tehranian A; Morris DW; Min BH; Bird DJ; Cardiff RD; Barry PA. 1996. Neoplastic transformation of prostatic and urogenital epithelium by the polyoma virus middle T gene. Am J Pathol 149(4):1177-91. PubMed: 8863667MGI: J:101640
- Thienpont B; Steinbacher J; Zhao H; D'Anna F; Kuchnio A; Ploumakis A; Ghesquiere B; Van Dyck L; Boeckx B; Schoonjans L; Hermans E; Amant F; Kristensen VN; Koh KP; Mazzone M; Coleman ML; Carell T; Carmeliet P; Lambrechts D. 2016. Tumour hypoxia causes DNA hypermethylation by reducing TET activity. Nature 537(7618):63-68. PubMed: 27533040MGI: J:236607
- Thion MS; McGuire JR; Sousa CM; Fuhrmann L; Fitamant J; Leboucher S; Vacher S; du Montcel ST; Bieche I; Bernet A; Mehlen P; Vincent-Salomon A; Humbert S. 2015. Unraveling the Role of Huntingtin in Breast Cancer Metastasis. J Natl Cancer Inst 107(10):. PubMed: 26293574MGI: J:225968
- Tran HD; Luitel K; Kim M; Zhang K; Longmore GD; Tran DD. 2014. Transient SNAIL1 expression is necessary for metastatic competence in breast cancer. Cancer Res 74(21):6330-40. PubMed: 25164016MGI: J:216694
- Tran K; Risingsong R; Royce DB; Williams CR; Sporn MB; Pioli PA; Gediya LK; Njar VC; Liby KT. 2013. The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer. Carcinogenesis 34(1):199-210. PubMed: 23042302MGI: J:193646
- Trimble MS; Xin JH; Guy CT; Muller WJ; Hassell JA. 1993. PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas. Oncogene 8(11):3037-42. PubMed: 7692372MGI: J:72260
- Trimboli AJ; Cantemir-Stone CZ; Li F; Wallace JA; Merchant A; Creasap N; Thompson JC; Caserta E; Wang H; Chong JL; Naidu S; Wei G; Sharma SM; Stephens JA; Fernandez SA; Gurcan MN; Weinstein MB; Barsky SH; Yee L; Rosol TJ; Stromberg PC; Robinson ML; PepinF; Hallett M; Park M; Ostrowski MC; Leone G. 2009. Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature 461(7267):1084-91. PubMed: 19847259MGI: J:153747
- Trimboli AJ; Fukino K; de Bruin A; Wei G; Shen L; Tanner SM; Creasap N; Rosol TJ; Robinson ML; Eng C; Ostrowski MC; Leone G. 2008. Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res 68(3):937-45. PubMed: 18245497MGI: J:131862
- Ursini-Siegel J; Hardy WR; Zuo D; Lam SH; Sanguin-Gendreau V; Cardiff RD; Pawson T; Muller WJ. 2008. ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J 27(6):910-20. PubMed: 18273058MGI: J:133325
- Van Overmeire E; Stijlemans B; Heymann F; Keirsse J; Morias Y; Elkrim Y; Brys L; Abels C; Lahmar Q; Ergen C; Vereecke L; Tacke F; De Baetselier P; Van Ginderachter JA; Laoui D. 2016. M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment. Cancer Res 76(1):35-42. PubMed: 26573801MGI: J:230585
- Vasiljeva O; Korovin M; Gajda M; Brodoefel H; Bojic L; Kruger A; Schurigt U; Sevenich L; Turk B; Peters C; Reinheckel T. 2008. Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice. Oncogene 27(30):4191-9. PubMed: 18345026MGI: J:138505
- Vasiljeva O; Papazoglou A; Kruger A; Brodoefel H; Korovin M; Deussing J; Augustin N; Nielsen BS; Almholt K; Bogyo M; Peters C; Reinheckel T. 2006. Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res 66(10):5242-50. PubMed: 16707449MGI: J:109056
- Versteeg HH; Schaffner F; Kerver M; Ellies LG; Andrade-Gordon P; Mueller BM; Ruf W. 2008. Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice. Cancer Res 68(17):7219-27. PubMed: 18757438MGI: J:138924
- Vervoort VS; Lu M; Valencia F; Lesperance J; Breier G; Oshima R; Pasquale EB. 2008. A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature. Transgenic Res 17(3):403-15. PubMed: 18027100MGI: J:134089
- Vila IK; Yao Y; Kim G; Xia W; Kim H; Kim SJ; Park MK; Hwang JP; Gonzalez-Billalabeitia E; Hung MC; Song SJ; Song MS. 2017. A UBE2O-AMPKalpha2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell 31(2):208-224. PubMed: 28162974MGI: J:239679
- Vomachka AJ; Pratt SL; Lockefeer JA; Horseman ND. 2000. Prolactin gene-disruption arrests mammary gland development and retards T-antigen-induced tumor growth. Oncogene 19(8):1077-84. PubMed: 10713693MGI: J:61017
- Wallace JA; Li F; Balakrishnan S; Cantemir-Stone CZ; Pecot T; Martin C; Kladney RD; Sharma SM; Trimboli AJ; Fernandez SA; Yu L; Rosol TJ; Stromberg PC; Lesurf R; Hallett M; Park M; Leone G; Ostrowski MC. 2013. Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer. PLoS One 8(8):e71533. PubMed: 23977064MGI: J:206347
- Walsh CA; Bolger JC; Byrne C; Cocchiglia S; Hao Y; Fagan A; Qin L; Cahalin A; McCartan D; McIlroy M; O'Gaora P; Xu J; Hill AD; Young LS. 2014. Global gene repression by the steroid receptor coactivator SRC-1 promotes oncogenesis. Cancer Res 74(9):2533-44. PubMed: 24648347MGI: J:210822
- Wan L; Lu X; Yuan S; Wei Y; Guo F; Shen M; Yuan M; Chakrabarti R; Hua Y; Smith HA; Blanco MA; Chekmareva M; Wu H; Bronson RT; Haffty BG; Xing Y; Kang Y. 2014. MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors. Cancer Cell 26(1):92-105. PubMed: 24981741MGI: J:214244
- Wan Y; Emtage P; Foley R; Carter R; Gauldie J. 1999. Murine dendritic cells transduced with an adenoviral vector expressing a defined tumor antigen can overcome anti-adenovirus neutralizing immunity and induce effective tumor regression. Int J Oncol 14(4):771-6. PubMed: 10087328MGI: J:54273
- Wang S; Yuan Y; Liao L; Kuang SQ; Tien JC; O'Malley BW; Xu J. 2009. Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation. Proc Natl Acad Sci U S A 106(1):151-6. PubMed: 19109434MGI: J:143510
- Wang Z; Xiong S; Mao Y; Chen M; Ma X; Zhou X; Ma Z; Liu F; Huang Z; Luo Q; Ouyang G. 2016. Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis. J Pathol 239(4):484-95. PubMed: 27193093MGI: J:241550
- Webster MA; Hutchinson JN; Rauh MJ; Muthuswamy SK; Anton M; Tortorice CG; Cardiff RD; Graham FL; Hassell JA; Muller WJ. 1998. Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol 18(4):2344-59. PubMed: 9528804MGI: J:56327
- Webster MA; Martin-Soudant N; Nepveu A; Cardiff RD; Muller WJ. 1998. The induction of uterine leiomyomas and mammary tumors in transgenic mice expressing polyomavirus (PyV) large T (LT) antigen is associated with the ability of PyV LT antigen to form specific complexes with retinoblastoma and CUTL1 family members. Oncogene 16(15):1963-72. PubMed: 9591780MGI: J:56288
- Wei H; Wei S; Gan B; Peng X; Zou W; Guan JL. 2011. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev 25(14):1510-27. PubMed: 21764854MGI: J:174193
- Welford AF; Biziato D; Coffelt SB; Nucera S; Fisher M; Pucci F; Di Serio C; Naldini L; De Palma M; Tozer GM; Lewis CE. 2011. TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice. J Clin Invest 121(5):1969-73. PubMed: 21490397MGI: J:173948
- Welm AL; Sneddon JB; Taylor C; Nuyten DS; van de Vijver MJ; Hasegawa BH; Bishop JM. 2007. The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. Proc Natl Acad Sci U S A 104(18):7570-5. PubMed: 17456594MGI: J:121299
- White DE; Kurpios NA; Zuo D; Hassell JA; Blaess S; Mueller U; Muller WJ. 2004. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 6(2):159-70. PubMed: 15324699MGI: J:92547
- Whitley MJ; Cardona DM; Lazarides AL; Spasojevic I; Ferrer JM; Cahill J; Lee CL; Snuderl M; Blazer DG 3rd; Hwang ES; Greenup RA; Mosca PJ; Mito JK; Cuneo KC; Larrier NA; O'Reilly EK; Riedel RF; Eward WC; Strasfeld DB; Fukumura D; Jain RK; Lee WD; Griffith LG; Bawendi MG; Kirsch DG; Brigman BE. 2016. A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. Sci Transl Med 8(320):320ra4. PubMed: 26738797MGI: J:234124
- Williams TM; Cheung MW; Park DS; Razani B; Cohen AW; Muller WJ; Di Vizio D; Chopra NG; Pestell RG; Lisanti MP. 2003. Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Mol Biol Cell 14(3):1027-42. PubMed: 12631721MGI: J:132472
- Williams TM; Medina F; Badano I; Hazan RB; Hutchinson J; Muller WJ; Chopra NG; Scherer PE; Pestell RG; Lisanti MP. 2004. Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem 279(49):51630-46. PubMed: 15355971MGI: J:95195
- Williams TM; Sotgia F; Lee H; Hassan G; Di Vizio D; Bonuccelli G; Capozza F; Mercier I; Rui H; Pestell RG; Lisanti MP. 2006. Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: caveolin-1 antagonizes cyclin d1 function in mammary epithelial cells. Am J Pathol 169(5):1784-801. PubMed: 17071600MGI: J:114569
- Wolford CC; McConoughey SJ; Jalgaonkar SP; Leon M; Merchant AS; Dominick JL; Yin X; Chang Y; Zmuda EJ; O'Toole SA; Millar EK; Roller SL; Shapiro CL; Ostrowski MC; Sutherland RL; Hai T. 2013. Transcription factor ATF3 links host adaptive response to breast cancer metastasis. J Clin Invest 123(7):2893-906. PubMed: 23921126MGI: J:201626
- Wong CS; Moller A. 2013. Siah: a promising anticancer target. Cancer Res 73(8):2400-6. PubMed: 23455005MGI: J:197053
- Wong CS; Sceneay J; House CM; Halse HM; Liu MC; George J; Hunnam TC; Parker BS; Haviv I; Ronai Z; Cullinane C; Bowtell DD; Moller A. 2012. Vascular normalization by loss of Siah2 results in increased chemotherapeutic efficacy. Cancer Res 72(7):1694-704. PubMed: 22354750MGI: J:184932
- Wong SY; Crowley D; Bronson RT; Hynes RO. 2008. Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer. Clin Exp Metastasis 25(2):109-18. PubMed: 18058030MGI: J:133592
- Wyckoff JB; Wang Y; Lin EY; Li JF; Goswami S; Stanley ER; Segall JE; Pollard JW; Condeelis J. 2007. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 67(6):2649-56. PubMed: 17363585MGI: J:120318
- Xiao G; Deng A; Liu H; Ge G; Liu X. 2012. Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1. Proc Natl Acad Sci U S A 109(38):15419-24. PubMed: 22949674MGI: J:190150
- Xue C; Plieth D; Venkov C; Xu C; Neilson EG. 2003. The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. Cancer Res 63(12):3386-94. PubMed: 12810675MGI: J:83971
- Yang D; Stewart TJ; Smith KK; Georgi D; Abrams SI; Liu K. 2008. Downregulation of IFN-gammaR in association with loss of Fas function is linked to tumor progression. Int J Cancer 122(2):350-62. PubMed: 17918178MGI: J:135543
- Yang H; Rouse J; Lukes L; Lancaster M; Veenstra T; Zhou M; Shi Y; Park YG; Hunter K. 2004. Caffeine suppresses metastasis in a transgenic mouse model: a prototype molecule for prophylaxis of metastasis. Clin Exp Metastasis 21(8):719-35. PubMed: 16035617MGI: J:101443
- Yang L; Huang J; Ren X; Gorska AE; Chytil A; Aakre M; Carbone DP; Matrisian LM; Richmond A; Lin PC; Moses HL. 2008. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 13(1):23-35. PubMed: 18167337MGI: J:131064
- Ye D; Zhao Y; Hildebrand RB; Singaraja RR; Hayden MR; Van Berkel TJ; Van Eck M. 2011. The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice. Am J Pathol 178(1):413-22. PubMed: 21224078MGI: J:168077
- Ye X; Tam WL; Shibue T; Kaygusuz Y; Reinhardt F; Ng Eaton E; Weinberg RA. 2015. Distinct EMT programs control normal mammary stem cells and tumour-initiating cells. Nature 525(7568):256-60. PubMed: 26331542MGI: J:225955
- Yeh IJ; Ogba N; Bensigner H; Welford SM; Montano MM. 2013. HEXIM1 down-regulates hypoxia-inducible factor-1alpha protein stability. Biochem J 456(2):195-204. PubMed: 24015760MGI: J:203807
- Yeo EJ; Cassetta L; Qian BZ; Lewkowich I; Li JF; Stefater JA 3rd; Smith AN; Wiechmann LS; Wang Y; Pollard JW; Lang RA. 2014. Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer. Cancer Res 74(11):2962-73. PubMed: 24638982MGI: J:211687
- Yeo SK; Wen J; Chen S; Guan JL. 2016. Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfbeta/Smad Signaling. Cancer Res 76(11):3397-410. PubMed: 27197172MGI: J:232037
- Yori JL; Lozada KL; Seachrist DD; Mosley JD; Abdul-Karim FW; Booth CN; Flask CA; Keri RA. 2014. Combined SFK/mTOR inhibition prevents rapamycin-induced feedback activation of AKT and elicits efficient tumor regression. Cancer Res 74(17):4762-71. PubMed: 25023728MGI: J:214234
- Yuan L; Lv Y; Li H; Gao H; Song S; Zhang Y; Xing G; Kong X; Wang L; Li Y; Zhou T; Gao D; Xiao ZX; Yin Y; Wei W; He F; Zhang L. 2015. Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat Cell Biol 17(9):1169-81. PubMed: 26280536MGI: J:227354
- Yuzefovych LV; Kahn AG; Schuler MA; Eide L; Arora R; Wilson GL; Tan M; Rachek LI. 2016. Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis. Cancer Res 76(1):30-4. PubMed: 26586787MGI: J:237561
- Zabuawala T; Taffany DA; Sharma SM; Merchant A; Adair B; Srinivasan R; Rosol TJ; Fernandez S; Huang K; Leone G; Ostrowski MC. 2010. An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. Cancer Res 70(4):1323-33. PubMed: 20145133MGI: J:157608
- Zagozdzon AM; O'Leary P; Callanan JJ; Crown J; Gallagher WM; Zagozdzon R. 2012. Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice. BMC Cancer 12:209. PubMed: 22646761MGI: J:226316
- Zhang H; Kuang SQ; Liao L; Zhou S; Xu J. 2004. Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation and accelerates polyoma middle-T antigen-induced mammary tumorigenesis in mice. Cancer Res 64(19):7169-77. PubMed: 15466215MGI: J:93653
- Zhang H; Stephens LC; Kumar R. 2006. Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. Clin Cancer Res 12(5):1479-86. PubMed: 16533771MGI: J:110213
- Zhang Q; Qin J; Zhong L; Gong L; Zhang B; Zhang Y; Gao WQ. 2015. CCL5-Mediated Th2 Immune Polarization Promotes Metastasis in Luminal Breast Cancer. Cancer Res 75(20):4312-21. PubMed: 26249173MGI: J:225872
- Zhao Y; Kumbrink J; Lin BT; Bouton AH; Yang S; Toselli PA; Kirsch KH. 2013. Expression of a phosphorylated substrate domain of p130Cas promotes PyMT-induced c-Src-dependent murine breast cancer progression. Carcinogenesis 34(12):2880-90. PubMed: 23825155MGI: J:204348
- Zhao Z; Zhu X; Cui K; Mancuso J; Federley R; Fischer K; Teng GJ; Mittal V; Gao D; Zhao H; Wong ST. 2016. In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors. Cancer Res 76(8):2094-104. PubMed: 26893478MGI: J:231694
- Zhu M; Yi M; Kim CH; Deng C; Li Y; Medina D; Stephens RM; Green JE. 2011. Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage. Genome Biol 12(8):R77. PubMed: 21846369MGI: J:216041
- Zomer A; Maynard C; Verweij FJ; Kamermans A; Schafer R; Beerling E; Schiffelers RM; de Wit E; Berenguer J; Ellenbroek SI; Wurdinger T; Pegtel DM; van Rheenen J. 2015. In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior. Cell 161(5):1046-57. PubMed: 26000481MGI: J:233460
- Zoratti GL; Tanabe LM; Varela FA; Murray AS; Bergum C; Colombo E; Lang JE; Molinolo AA; Leduc R; Marsault E; Boerner J; List K. 2015. Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun 6:6776. PubMed: 25873032MGI: J:222717