These mice carry the spontaneous pdw (proportional dwarf) mutation and are characterized by shortened limbs, tail, head, and body.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | pdw | proportional dwarf |
Mice homozygous for the recessive proportional dwarf (pdw) mutation can be identified by 25 days of age, having shortened limbs, tail, head, and body. Abnormalities were not detected in growth plates and skeletal mineralization patterns. Some pre-wean mortality has been reported. Both female and male homozygotes are fertile. (Sweet et al., 1992.)
The proportional dwarf mutation (pwd) arose spontaneously on the DBA/2J background at The Jackson Laboratory in 1991. This mutation was maintained segregating through sibling matings, generally heterozygote x homozygote and vice versa but also heterozygote x heterozygote. In 1996 DBA/2J females were bred with pwd homozygous males to generate embryos for cryopreservation.
Allele Name | proportional dwarf |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | pdw, proportional dwarf |
Gene Synonym(s) | |
Strain of Origin | DBA/2J |
Chromosome | 8 |
Molecular Note | The proportional dwarf mutation (pwd) arose spontaneously on the DBA/2J background at The Jackson Laboratory in 1991. |
When using the proportional dwarf mouse strain in a publication, please cite the originating article(s) and include JAX stock #002337 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for pdw |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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