Mice homozygous for the recessive proportional dwarf (pdw) mutation can be identified by 25 days of age, having shortened limbs, tail, head, and body. Abnormalities were not detected in growth plates and skeletal mineralization patterns. Some pre-wean mortality has been reported. Both female and male homozygotes are fertile. (Sweet et al., 1992.)
The proportional dwarf mutation (pwd) arose spontaneously on the DBA/2J background at The Jackson Laboratory in 1991. This mutation was maintained segregating through sibling matings, generally heterozygote x homozygote and vice versa but also heterozygote x heterozygote. In 1996 DBA/2J females were bred with pwd homozygous males to generate embryos for cryopreservation.
|Allele Name||proportional dwarf|
|Gene Symbol and Name||pdw, proportional dwarf|
|Strain of Origin||DBA/2J|
|Molecular Note||The proportional dwarf mutation (pwd) arose spontaneously on the DBA/2J background at The Jackson Laboratory in 1991.|