These Fos knock-out mice exhibit reduced placental and fetal weights and significant loss of viability at birth. Surviving mice show other abnormalities including osteopetrosis.
Dr. Virginia E. Papaioannou, Columbia University
Mice homozygous for the Fostm1Pa mutation show reduced placental and fetal weights, lack teeth, and have a significant pre-weaning loss of viability. Survivors grow at a normal rate until about 11 days of age when they begin to develop a severe osteopetrosis. They may live as long as 5-7 months. Homozygous mice have delayed or absent gametogenesis and show lymphopenia. They also exhibit behavioral abnormalities, including hyperactivity and diminished response to external stimuli.
The Fostm1Pa mutant strain was developed in the laboratory of Dr. Virginia E. Papaioannou at Columbia University. The 129-derived PJ5 ES cell line was used.
|Allele Name||targeted mutation 1, Virginia E Papaioannou|
|Allele Type||Targeted (Null/Knockout)|
|Gene Symbol and Name||Fos, FBJ osteosarcoma oncogene|
|Strain of Origin||129X1/SvJ|
|Molecular Note||Exon 1 was disrupted by the insertion of a neomycin selection cassette. Northern blot analysis showed an absence of transcript in homozygous mutant mice.|
|Mutations Made By|| |
Dr. Virginia Papaioannou, Columbia University
When using the c-fos KO mouse strain in a publication, please cite the originating article(s) and include JAX stock #002293 in your Materials and Methods section.