B6;129X1-Fos^tm1Pa/J

Stock number: 002293
Product name: c-fos KO
Research areas: Cancer Research, Developmental Biology Research, Immunology, Inflammation and Autoimmunity Research, Internal/Organ Research, Neurobiology Research, Reproductive Biology Research

Description

These Fos knock-out mice exhibit reduced placental and fetal weights and significant loss of viability at birth. Surviving mice show other abnormalities including osteopetrosis.

Detailed description

Mice homozygous for the Fos^tm1Pa mutation show reduced placental and fetal weights, lack teeth, and have a significant pre-weaning loss of viability. Survivors grow at a normal rate until about 11 days of age when they begin to develop a severe osteopetrosis. They may live as long as 5-7 months. Homozygous mice have delayed or absent gametogenesis and show lymphopenia. They also exhibit behavioral abnormalities, including hyperactivity and diminished response to external stimuli.

Development

The Fos^tm1Pa mutant strain was developed in the laboratory of Dr. Virginia E. Papaioannou at Columbia University. The 129-derived PJ5 ES cell line was used.

Allele

Symbol: Fos^tm1Pa
Name: targeted mutation 1, Virginia E Papaioannou
MGI accession ID: MGI:1857171
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Fos
Marker name: FBJ osteosarcoma oncogene
Chromosome: 12
Strain of origin: 129X1/SvJ
Molecular note: Exon 1 was disrupted by the insertion of a neomycin selection cassette. Northern blot analysis showed an absence of transcript in homozygous mutant mice.