Mice homozygous for the Itga5tm1Hyn targeted mutation die during embryonic development. Homozygous mutant embryos exhibit defects in the vasculature of the yolk sac and the embyro as well as severe defects in posterior and extraembryonic mesoderm. Implantation and initiation of gastrulation and neurulation is normal. There is normal development of notochord, somite and considerable development of brain, optic and otic anlagen and branchial arches.

These Itga5 knock-out mice exhibit embryonic lethality with defects in posterior trunk and yolk sac mesodermal structures.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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