These Itga5 knock-out mice exhibit embryonic lethality with defects in posterior trunk and yolk sac mesodermal structures.
Dr. Richard Hynes, Massachusetts Institute of Technology
Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Itga5 | integrin alpha 5 (fibronectin receptor alpha) |
Mice homozygous for the Itga5tm1Hyn targeted mutation die during embryonic development. Homozygous mutant embryos exhibit defects in the vasculature of the yolk sac and the embyro as well as severe defects in posterior and extraembryonic mesoderm. Implantation and initiation of gastrulation and neurulation is normal. There is normal development of notochord, somite and considerable development of brain, optic and otic anlagen and branchial arches.
Allele Name | targeted mutation 1, Richard Hynes |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | alpha5-; alpha5-null |
Gene Symbol and Name | Itga5, integrin alpha 5 (fibronectin receptor alpha) |
Gene Synonym(s) | |
Strain of Origin | 129S2/SvPas |
Chromosome | 15 |
Molecular Note | A neomycin resistance cassette replaced 330 bp of the gene, deleting most of the first exon. |
Mutations Made By | Dr. Richard Hynes, Massachusetts Institute of Technology |
When using the α5-null mouse strain in a publication, please cite the originating article(s) and include JAX stock #002274 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Itga5<tm1Hyn> |
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