B6.129S-Itga5^tm1Hyn/J

Stock number: 002274
Product name: α5-null
Research areas: Cancer Research, Cardiovascular Research, Cell Biology Research, Developmental Biology Research, Immunology, Inflammation and Autoimmunity Research, Internal/Organ Research, Research Tools

Description

These Itga5 knock-out mice exhibit embryonic lethality with defects in posterior trunk and yolk sac mesodermal structures.

Detailed description

Mice homozygous for the Itga5^tm1Hyn targeted mutation die during embryonic development. Homozygous mutant embryos exhibit defects in the vasculature of the yolk sac and the embyro as well as severe defects in posterior and extraembryonic mesoderm. Implantation and initiation of gastrulation and neurulation is normal. There is normal development of notochord, somite and considerable development of brain, optic and otic anlagen and branchial arches.

Allele

Symbol: Itga5^tm1Hyn
Name: targeted mutation 1, Richard Hynes
MGI accession ID: MGI:1857207
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Itga5
Marker name: integrin alpha 5 (fibronectin receptor alpha)
Chromosome: 15
Strain of origin: 129S2/SvPas
Molecular note: A neomycin resistance cassette replaced 330 bp of the gene, deleting most of the first exon.