B10.129S2(B6)-Ighm^tm1Cgn/J

Stock number: 002249
Product name: muMt^-
Research areas: Immunology, Inflammation and Autoimmunity Research, Research Tools

Description

Mice homozygous for the Ighm^tm1Cgn knock-out mutation have a disruption of one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM) and lack mature B-cells. These mice may be useful as a model for B-cell immunodeficiency found in humans.

Detailed description

Mice homozygous for the Ighm^tm1Cgn targeted mutation are viable and fertile. Homozygous mutant mice lack mature B-cells. There is no expression of membrane-bound IgM, although some B-cells may be produced using a C gene other than mu. It may be useful as a model for B-cell immunodeficiency found in humans. Also know as muMT.

Allele

Symbol: Ighm^tm1Cgn
Name: targeted mutation 1, University of Cologne
MGI accession ID: MGI:1857187
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Ighm
Marker name: immunoglobulin heavy constant mu
Chromosome: 12
Strain of origin: 129S2/SvPas
Molecular note: A neomycin resistance cassette disrupted one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM).