Mice homozygous for the Ighmtm1Cgn knock-out mutation have a disruption of one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM) and lack mature B-cells. These mice may be useful as a model for B-cell immunodeficiency found in humans.
Klaus Rajewsky, Max Delbruck Centre for Molecular Medicine
Mice homozygous for the Ighmtm1Cgn targeted mutation are viable and fertile. Homozygous mutant mice lack mature B-cells. There is no expression of membrane-bound IgM, although some B-cells may be produced using a C gene other than mu. It may be useful as a model for B-cell immunodeficiency found in humans. Also know as muMT.
|Allele Name||targeted mutation 1, University of Cologne|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||B cell-; BCKO; BCR-; BKO; Cmu -; Ig- muMT; Ig-; IgH-; IgHmuMT; Igh-6-; Igh-6null; Igh-6tm1Cgn; Igh-6tm1CgnmuMT0; Ighm-; Igmunull; muIgKO; mum-; muMT; muMt-; mu-MT-|
|Gene Symbol and Name||Ighm, immunoglobulin heavy constant mu|
|Strain of Origin||129S2/SvPas|
|Molecular Note||A neomycin resistance cassette disrupted one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM).|
|Mutations Made By|| |
Daisuke Kitamura, University of Cologne
When maintaining a live colony, these mice can be bred as homozygotes. The expected coat color from breeding is black.
When using the muMt- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002249 in your Materials and Methods section.