Mice homozygous for the Ighmtm1Cgn knock-out mutation have a disruption of one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM) and lack mature B-cells. These mice may be useful as a model for B-cell immunodeficiency found in humans.
Klaus Rajewsky, Max Delbruck Centre for Molecular Medicine
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Ighm | immunoglobulin heavy constant mu |
Mice homozygous for the Ighmtm1Cgn targeted mutation are viable and fertile. Homozygous mutant mice lack mature B-cells. There is no expression of membrane-bound IgM, although some B-cells may be produced using a C gene other than mu. It may be useful as a model for B-cell immunodeficiency found in humans. Also know as muMT.
Allele Name | targeted mutation 1, University of Cologne |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | B cell-; BCKO; BCR-; BKO; Cmu -; Ig- muMT; Ig-; IgH-; IgHmuMT; Igh-6-; Igh-6null; Igh-6tm1Cgn; Igh-6tm1CgnmuMT0; Ighm-; Igmunull; muIgKO; mum-; muMT; muMt-; mu-MT- |
Gene Symbol and Name | Ighm, immunoglobulin heavy constant mu |
Gene Synonym(s) | |
Strain of Origin | 129S2/SvPas |
Chromosome | 12 |
Molecular Note | A neomycin resistance cassette disrupted one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM). |
Mutations Made By | Daisuke Kitamura, University of Cologne |
When maintaining a live colony, these mice can be bred as homozygotes. The expected coat color from breeding is black.
When using the muMt- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002249 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous for Igh-6<tm1Cgn>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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