It has been reported that mice homozygous for Tgfb1tm1Doe mutation develop normally but die approximately two to three weeks after birth. It was also reported that this strain shows a lower than expected number of homozygous births (~14% from heterozygous matings on a mixed genetic background) suggesting that in utero death may occur (See Husbandry). Homozygous mice usually die within a few days of the onset of a wasting syndrome. Death is due to a massive inflammatory cell response and tissue necrosis. A multifocal mixed inflammatory cell infiltration occurs into numerous organs, particularly the heart and stomach. Heterozygous mice do not differ from normal wildtype littermates. This strain may provide a model for human immune and inflammatory diseases such as autoimmune disease, transplant rejection and graft versus host reactions.

The observed recovery of homozygous mutants from heterozygote x heterozygote matings is 3.8% on the C57BL/6J genetic background. Homozygotes usually die by two to three weeks age. The literature suggests that a mixed or outbred genetic background can enhance the viability of homozygous knockout animals.

These Tgfb1 knock-out mice exhibit early postnatal death and a reduced number of expected homozygous births.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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