Jackson Laboratory SEARCH FOR MICE
B6;C3Sn-Pde6b+ eyl5/Boc
Stock No: 002133
  • Spontaneous Mutation
Contact Customer Service
Contact Customer Service
  • Email
  • Download PDF
  • Print
  • Help
  • Overview
  • Details
    • Detailed Description
    • Development
    • Expression Data
    • Control Suggestions
    • Selected References
  • Genetics
  • Disease/Phenotype
    • Disease Terms
    • Research Areas By Phenotype
    • Mammalian Phenotype Terms by Genotype
    • References
  • Technical Support
    • Genotyping Protocols
    • Citation
    • Animal Health Reports
    • Contact Technical Support
  • Pricing & Availability
    • Price
    • Payment Terms
    • Related Products and Services
  • Terms Of Use
  • Related Strains

Overview

Eyeless 5 homozygotes have a high rate of anophthalmia and those with intact globes have microphthalmia and white corneal opacity.

Read More +

Genetic overview

Genetic Background Generation
N1F26N1F5
(2019-09-10 00:00:00)

Pde6b+

Allele Type Gene Symbol Gene Name
Not Applicable Pde6b phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide

eyl5

Allele Type Gene Symbol Gene Name
Spontaneous (Not Specified) eyl5 eyeless 5
View Genetics

Research Applications

  • Mouse/Human Gene Homologs
  • Sensorineural Research
  • Developmental Biology Research
View All Research Applications

Base Price

Starting at:

$250.20 Domestic price for female
View Price List

Details

Detailed Description

Eyeless 5 homozygotes have a high rate of anophthalmia and those with intact globes have microphthalmia and white corneal opacity. The genetic lesion underlying this spontaneous mutation has not yet been identified. This strain lacks the Pde6brd1 allele and carries the Y Chromosome from C3H/HeSn.

Development

The eyeless 5 mutation arose spontaneously in C3H/HeSn-ocd/J and a mutant male was crossed to a C57BL/6J female and their offspring were maintained by sibling intercrossing, selecting for Pde6b+ from C57BL/6J and eyl5 and breeding both to homozygosity. At generation N1F26 a breeding depression forced another outcross of a male homozygote to a female C57BL/6J followed again by sibling intercrossing to generate mice homozygous for both eyl5 and Pde6b+. Because of the pedigree, this strain happens to carry the Y Chromosome from C3H/HeSn. Sperm was cryopreserved from males homozygous for both eyl5 and Pde6b+.

Expression Data

Expressed Gene Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory
Site of ExpressionRetina.
Site of Expression

Control Suggestions

  • 000664 C57BL/6J

Additional Information

  • Considerations for Choosing Controls

Selected References

  • Chang B. 2019. The eyeless 5 mutation (eyl5) in mice. MGI Direct Data SubmissionMGI: J:278680
View All References

Genetics

Pde6b+

Allele Symbol: Pde6b+

Allele Name wild type
Allele Type Not Applicable
Allele Synonym(s)
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)
Expressed GenePde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory
Site of ExpressionRetina.
Strain of Origin Not Applicable
Chromosome 5

eyl5

Allele Symbol: eyl5

Allele Name eyeless 5
Allele Type Spontaneous (Not Specified)
Allele Synonym(s)
Gene Symbol and Name eyl5, eyeless 5
Gene Synonym(s)
Strain of Origin C3H/HeSn-ocd/J
Chromosome 12
Molecular Note This spontaneous heritable phenotype was mapped to Chromosome 12 between D12Mit60 and D12Mit54.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Pde6b+ related

  • Mouse/Human Gene Homologs
    • retinitis pigmentosa, wildtype
  • Sensorineural Research
    • Retinal Degeneration
      • wild-type
  • Developmental Biology Research
    • Eye Defects
  • Sensorineural Research
    • Eye Defects

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: eyl5/eyl5
B6;C3Sn-Pde6b<+> eyl5/Boc

vision/eye phenotype

  • corneal opacity
      (MGI Ref ID J:278680)
  • microphthalmia
      (MGI Ref ID J:278680)
  • anophthalmia
    • most homozygotes have anophthalmia and those with intact globes have microphthalmia and white corneal opacity
    • (MGI Ref ID J:278680)

References

  • Chang B. 2019. The eyeless 5 mutation (eyl5) in mice. MGI Direct Data SubmissionMGI: J:278680

Additional - eyl5 related

Additional - Pde6b+ related

Technical Support

CONTACT TECHNICAL SUPPORT
  • Genotyping Protocols

    • Genotyping resources and troubleshooting
  • Citation

    When using the B6;C3Sn-Pde6b+ eyl5/Boc mouse strain in a publication, please cite the originating article(s) and include JAX stock #002133 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

MGL277 (Low)

Pricing & Availability

Availability Varies
  • Domestic
  • International

Live Mouse

Age Genotype Price
weeks

Cryorecovery - Pricing

Service/Product Description Price
Heterozygous for nm1863 1pr minimum

Related Products and Services

Frozen Mouse EmbryoB6;C3Sn-Pde6b<+> eyl5/Boc $2595.00
Frozen Mouse EmbryoB6;C3Sn-Pde6b<+> eyl5/Boc $2595.00
Frozen Mouse EmbryoB6;C3Sn-Pde6b<+> eyl5/Boc $3373.50
Frozen Mouse EmbryoB6;C3Sn-Pde6b<+> eyl5/Boc $3373.50

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470
Email: TechTran@jax.org

Related Strains

  • All
  • By Allele
  • By Gene
  • By Collection
View All Strains
There are no related strains using this filter.
▲
  • Stock No: |
    Related By:
▼
FEEDBACK
Did you find what you were looking for?

What information were you hoping to find through your search?

How easy was it to find what you were looking for?

We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.

Please Enter a Valid Email Address

Skip

Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.