Eyeless 5 homozygotes have a high rate of anophthalmia and those with intact globes have microphthalmia and white corneal opacity.
Read More +Genetic Background | Generation |
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N1F26N1F5
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Allele Type | Gene Symbol | Gene Name |
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Not Applicable | Pde6b | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
Allele Type | Gene Symbol | Gene Name |
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Spontaneous (Not Specified) | eyl5 | eyeless 5 |
Eyeless 5 homozygotes have a high rate of anophthalmia and those with intact globes have microphthalmia and white corneal opacity. The genetic lesion underlying this spontaneous mutation has not yet been identified. This strain lacks the Pde6brd1 allele and carries the Y Chromosome from C3H/HeSn.
The eyeless 5 mutation arose spontaneously in C3H/HeSn-ocd/J and a mutant male was crossed to a C57BL/6J female and their offspring were maintained by sibling intercrossing, selecting for Pde6b+ from C57BL/6J and eyl5 and breeding both to homozygosity. At generation N1F26 a breeding depression forced another outcross of a male homozygote to a female C57BL/6J followed again by sibling intercrossing to generate mice homozygous for both eyl5 and Pde6b+. Because of the pedigree, this strain happens to carry the Y Chromosome from C3H/HeSn. Sperm was cryopreserved from males homozygous for both eyl5 and Pde6b+.
Expressed Gene | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory |
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Site of Expression | Retina. |
Site of Expression |
Allele Name | wild type |
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Allele Type | Not Applicable |
Allele Synonym(s) | |
Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
Gene Synonym(s) | |
Expressed Gene | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory |
Site of Expression | Retina. |
Strain of Origin | Not Applicable |
Chromosome | 5 |
Allele Name | eyeless 5 |
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Allele Type | Spontaneous (Not Specified) |
Allele Synonym(s) | |
Gene Symbol and Name | eyl5, eyeless 5 |
Gene Synonym(s) | |
Strain of Origin | C3H/HeSn-ocd/J |
Chromosome | 12 |
Molecular Note | This spontaneous heritable phenotype was mapped to Chromosome 12 between D12Mit60 and D12Mit54. |
When using the B6;C3Sn-Pde6b+ eyl5/Boc mouse strain in a publication, please cite the originating article(s) and include JAX stock #002133 in your Materials and Methods section.
Service/Product | Description | Price |
---|---|---|
Heterozygous for nm1863 1pr minimum |
Frozen Mouse Embryo | B6;C3Sn-Pde6b<+> eyl5/Boc | $2595.00 |
Frozen Mouse Embryo | B6;C3Sn-Pde6b<+> eyl5/Boc | $2595.00 |
Frozen Mouse Embryo | B6;C3Sn-Pde6b<+> eyl5/Boc | $3373.50 |
Frozen Mouse Embryo | B6;C3Sn-Pde6b<+> eyl5/Boc | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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