JAX Mouse Strain Datasheet - 002101

B6.129S2-Trp53^tm1Tyj/J

Stock No:: 002101 |; p53 KO

Repository Live

Overview

Also Known As: p53 KO

Trp53 knockout mutant mice develop tumors at three to six months of age. They are suitable for use in applications related to the study of familial breast cancers such as Li-Fraumeni syndrome as well as research of lung, brain and bone tumors, lymphoma and leukemia, and other rare cancers.

Donating Investigator

IMR Colony, The Jackson Laboratory

Genetic overview

Genetic Background	Generation
000664 C57BL/6J	N5F6pF1+N1F11 (16-JAN-18)

Trp53^tm1Tyj

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Trp53	transformation related protein 53

View Genetics

Research Applications

Apoptosis Research
Cancer Research
Immunology, Inflammation and Autoimmunity Research
Research Tools

View All Research Applications

Base Price

Starting at:

$246.50 Domestic price for female 4-week

$510.00 Domestic price for breeder pair

View Price List

Details

Detailed Description

A neomycin cassette replaces exons 2-6 (including the start codon) of the transformation related protein 53 gene (Trp53). Mice homozygous for the mutation show no visible phenotype but most develop tumors (principally lymphomas and sarcomas) at three to six months of age. Heterozygous mice develop tumors at about 10 months of age. These mice model some of the features of human Li-Fraumeni syndrome, a form of familial breast cancer with mutations in TRP53. Homozygous mice may produce a litter before succumbing to tumors.
For the C57BL/6-J congenic Trp53^tm1Tyj mouse line (Stock No. 002101), it is the experience of The Jackson Laboratory that homozygous males have expected Mendelian survival rates at wean age, but homozygous females have significantly reduced survival by wean age. Specifically, breeding heterozygous females to heterozygous males results in only ~3.5% homozygous females by wean age (expected Mendelian 12.5%). Additionally, breeding heterozygous females to homozygous males results in only ~6.8% homozygous females by wean age (expected Mendelian 25%).

Development

The Trp53^tm1Tyj mutant strain was developed in the laboratory of Dr. Tyler Jacks at the Center for Cancer Research at the Massachusetts Institute of Technology. The 129-derived D3 ES cell line was used. The C57BL/6J strain was produced by backcrossing the Trp53^tm1Tyj mutation at least five times to C57BL/6J inbred mice.

Control Suggestions

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Jacks T; Remington L; Williams BO; Schmitt EM; Halachmi S; Bronson RT; Weinberg RA. 1994. Tumor spectrum analysis in p53-mutant mice. Curr Biol 4(1):1-7. PubMed: 7922305 MGI: J:17728

View All References

Genetics

Trp53^tm1Tyj

Allele Symbol: Trp53^tm1Tyj

Allele Name	targeted mutation 1, Tyler Jacks
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	Trp53-; Trp53^KO; p53-; p53^delta; p53^null; p53KO
Gene Symbol and Name	Trp53, transformation related protein 53
Gene Synonym(s)	BCC7; LFS1; P53; TRP53; p44; p53
Site of Expression	Normal Trp53 expression is widespread.
Strain of Origin	129S2/SvPas
Chromosome	11
General Note	This mutant allele was produced by a targeted neo insertion into the Trp53 locus. Homozygotes show no visible phenotype but develop tumors at 3-6 months of age. Heterozygotes develop tumors at 10 months of age. These mice model some of the features of human Li-Fraumeni syndrome (OMIM 151623), a form of familial breast cancer with mutations in TRP53 (J:16022)(J:16023) A specific human mutation found in hepatocellular carcinomas caused by hepatitis B infection or by aflatoxin exposure has been created in a mouse model, resulting in a similar gene product (J:27363).
Molecular Note	A neomycin cassette replaced 40% of the coding sequences beginning with exon 2 (upstream of the translation start site) and extending into exon 6.
Mutations Made By	Dr. Tyler Jacks, Massachusetts Institute of Technology

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Trp53^tm1Tyj related

Apoptosis Research
- Endogenous Regulators
Cancer Research
- Increased Tumor Incidence
  - Lymphomas
  - Other Tissues/Organs
  - Other Tissues/Organs: osteosarcoma
- Toxicology
- Tumor Suppressor Genes
Immunology, Inflammation and Autoimmunity Research
- Intracellular Signaling Molecules
Research Tools
- Toxicology Research
  - B and T cell deficiency, xenograft transplant host
  - drug/compound testing

Mammalian Phenotype Terms by Genotype

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
B6.129S2-Trp53^tm1Tyj/J

cardiovascular system phenotype

abnormal retinal vasculature morphology
- Background Sensitivity - abnormal blood vessels are found to extend from the peripapillary inner retina through the posterior vitreous and into the retrolental membranes
- abnormally dilated peripheral retinal blood vessels

vision/eye phenotype

abnormal ocular fundus morphology
- Background Sensitivity - pigmented or nonpigmented fibrous retrolental tissue is commonly found in homozygotes on the C57BL/6J background

abnormal optic nerve morphology
- Background Sensitivity - the pial septae in many areas are disorganized on the C57BL/6J background but not the 129 or F1 backgrounds

abnormal posterior eye segment morphology
- Background Sensitivity - on the C57BL/6J background aberrant ocular phenotypes are observed as early as 14 days of age

abnormal retina morphology
- Background Sensitivity - retinal folds are found in some homozygotes on the C57BL/6J background

abnormal retinal vasculature morphology
- Background Sensitivity - abnormal blood vessels are found to extend from the peripapillary inner retina through the posterior vitreous and into the retrolental membranes
- abnormally dilated peripheral retinal blood vessels

opacity of vitreous body
- Background Sensitivity - fine snowflake-like vitreal opacities can be found on the C57BL/6J background by 21 days of age and may result from the accumulation of fibrous and vascular debris in the vitreous

optic nerve degeneration
- Background Sensitivity - degeneration is found to varying degrees on the C57BL/6J background, but not the 129 background

optic nerve hypoplasia
- Background Sensitivity - bilateral or unilateral optic nerve hypoplasia is found on the C57BL/6J background, but not on the 129 or F1 background

nervous system phenotype

abnormal optic nerve morphology
- Background Sensitivity - the pial septae in many areas are disorganized on the C57BL/6J background but not the 129 or F1 backgrounds

optic nerve degeneration
- Background Sensitivity - degeneration is found to varying degrees on the C57BL/6J background, but not the 129 background

optic nerve hypoplasia
- Background Sensitivity - bilateral or unilateral optic nerve hypoplasia is found on the C57BL/6J background, but not on the 129 or F1 background

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas * BALB/cJ * C57BL/6

neoplasm

abnormal tumor incidence
- 42.8% of mice (6 of 14) develop thymic lymphomas after exposure to ionizing radiation

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

mortality/aging

decreased survivor rate
- 50% survival at 63 weeks

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas * C57BL/6 * CBA

cellular phenotype

decreased thymocyte apoptosis
- radiation-induced apoptosis in the thymus is increased as compared to homozygous Trp53^tm1Tyj mice, but is decreased as compared to wild-type

endocrine/exocrine gland phenotype

decreased thymocyte apoptosis
- radiation-induced apoptosis in the thymus is increased as compared to homozygous Trp53^tm1Tyj mice, but is decreased as compared to wild-type

hematopoietic system phenotype

decreased thymocyte apoptosis
- radiation-induced apoptosis in the thymus is increased as compared to homozygous Trp53^tm1Tyj mice, but is decreased as compared to wild-type

immune system phenotype

decreased thymocyte apoptosis
- radiation-induced apoptosis in the thymus is increased as compared to homozygous Trp53^tm1Tyj mice, but is decreased as compared to wild-type

mortality/aging

premature death
- average lifespan is 14 months

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas * C57BL/6

mortality/aging

premature death
- 28% of mutants die by 17 months of age due to tumors
- heterozygous mutants die between 150 to 750 days after birth
- less than 5% of mice live past two years due to cancerous tumors

endocrine/exocrine gland phenotype

increased mammary adenocarcinoma incidence
- 2.9% incidence

increased pancreas tumor incidence
- 2.9% incidence of pancreatic adenocarcinomas

integument phenotype

increased mammary adenocarcinoma incidence
- 2.9% incidence

neoplasm

abnormal tumor morphology
- tumors show loss of heterozygosity for Trp53

increased adenocarcinoma incidence
- 18% incidence

increased adenoma incidence
- 5.9% incidence

increased carcinoma incidence
- 12% of heterozygous mutants developed carcinomas, which are rare in homozygotes
- 2.9% incidence of pancreatic adenocarcinomas
- 35% incidence of carcinomas

increased fibrosarcoma incidence

increased hemangiosarcoma incidence
- 8.8% incidence

increased histiocytic sarcoma incidence
- 15% incidence

increased leiomyosarcoma incidence

increased leukemia incidence
- is observed in 2.6% of mice by 24 months of age

increased lung adenocarcinoma incidence
- 12% incidence

increased lymphoma incidence
- 25% of mutants exhibit lymphomas
- 32% incidence
- 32% of heterozygous mutants developed lymphomas
- is observed in 18.4% of mice by 24 months of age

increased mammary adenocarcinoma incidence
- 2.9% incidence

increased osteosarcoma incidence
- 29% incidence

increased pancreas tumor incidence
- 2.9% incidence of pancreatic adenocarcinomas

increased rhabdomyosarcoma incidence

increased sarcoma incidence
- 2.9% incidence of undifferentiated sarcomas
- 56% incidence of sarcomas
- 56% of heterozygous mutants developed sarcomas
- 57% of mutants exhibit sarcomas

increased squamous cell carcinoma incidence
- 18% incidence of ear squamous cell carcinoma

increased tumor incidence
- age of onset 9 months
- over 95% of mice have tumors by 2 years of age

digestive/alimentary phenotype

gastric polyps
- 2.9% incidence of stomach polyps

intestine polyps
- 2.9% incidence of small intestinal polyps

muscle phenotype

increased leiomyosarcoma incidence

increased rhabdomyosarcoma incidence

respiratory system phenotype

increased lung adenocarcinoma incidence
- 12% incidence

skeleton phenotype

increased osteosarcoma incidence
- 29% incidence

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas

renal/urinary system phenotype

increased urinary system tumor incidence
- 12 of 45 mice treated with 2-AAF develop urinary bladder tumors

mortality/aging

premature death
- mean life span is 15.4 months

neoplasm

increased carcinoma incidence
- 4 of 37 develop low grade carcinomas including 1 with a well differentiated lung carcinoma

increased incidence of tumors by chemical induction
- 12 of 45 mice treated with 2-AAF develop urinary bladder tumors

increased tumor incidence
- 19% have multiple tumors compared to 44% of Trp53^tm3.1Tyj heterozygotes

increased urinary system tumor incidence
- 12 of 45 mice treated with 2-AAF develop urinary bladder tumors

cellular phenotype

decreased thymocyte apoptosis
- in response to irradiation

increased fibroblast proliferation
- a larger fraction of MEFs are in S phase compared to wild-type mice

hematopoietic system phenotype

abnormal hematopoietic system physiology
- hematopoietic stem and progenitor cells (HSPC) from irradiated mice transplanted into irradiated mice reconstitute the HSPC population exhibit a competitive advantage over HSPC from untreated mice compared with cells from similarly irradiated wild-type micece
- however, no competitive advantage is observed over similarly treated Cdkn2a^tm2.1Rdp cells in irradiation chimera experiments

decreased thymocyte apoptosis
- in response to irradiation

immune system phenotype

decreased thymocyte apoptosis
- in response to irradiation

homeostasis/metabolism phenotype

increased incidence of tumors by chemical induction
- 12 of 45 mice treated with 2-AAF develop urinary bladder tumors

endocrine/exocrine gland phenotype

decreased thymocyte apoptosis
- in response to irradiation

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas * C57BL/6 * FVB/N

mortality/aging

premature death
- median survival is 64 weeks

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
129-Trp53^tm1Tyj/J

cardiovascular system phenotype

abnormal retinal vasculature morphology
- Background Sensitivity - abnormally dilated peripheral retinal blood vessels, with some mice exhibiting thin blood vessels extending from the optic nerve head toward the lens, but few reach the lens surface

vision/eye phenotype

abnormal retinal vasculature morphology
- Background Sensitivity - abnormally dilated peripheral retinal blood vessels, with some mice exhibiting thin blood vessels extending from the optic nerve head toward the lens, but few reach the lens surface

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas * FVB/N

cellular phenotype

decreased cellular sensitivity to ionizing radiation
- following ionizing radiation treatment, arrested cell growth in the epidermis is partially abrogated compared to in similarly treated wild-type mice
- following ionizing radiation treatment, hair follicles do not exhibit apoptosis unlike in similarly treated wild-type mice

integument phenotype

decreased sensitivity to skin irradiation
- following ionizing radiation treatment, arrested cell growth in the epidermis is partially abrogated compared to in similarly treated wild-type mice

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas * C57BL/6 * FVB/N

mortality/aging

decreased mortality induced by ionizing radiation
- median survival following exposure to 8 gray of whole body gamma-irradiation is 34 days

premature death
- longest lifespan is 34 weeks, median survival is 25 weeks

homeostasis/metabolism phenotype

decreased mortality induced by ionizing radiation
- median survival following exposure to 8 gray of whole body gamma-irradiation is 34 days

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas * C57BL/6 * CBA

cellular phenotype

decreased thymocyte apoptosis
- radiation-induced apoptosis in the thymus is decreased as compared to wild-type

endocrine/exocrine gland phenotype

decreased thymocyte apoptosis
- radiation-induced apoptosis in the thymus is decreased as compared to wild-type

hematopoietic system phenotype

decreased thymocyte apoptosis
- radiation-induced apoptosis in the thymus is decreased as compared to wild-type

immune system phenotype

decreased thymocyte apoptosis
- radiation-induced apoptosis in the thymus is decreased as compared to wild-type

mortality/aging

premature death
- average lifespan is 4.5 months

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas * BALB/c

cellular phenotype

increased cellular sensitivity to ionizing radiation
- at P10, pattern and extent of oocyte loss in ovaries of mutants after exposure to 0.45 Gy radiation on P5 is similar to wild-type and much more sever than Trp63^tm2Fmc mutants

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas * C57BL/6

endocrine/exocrine gland phenotype

increased T cell derived lymphoma incidence
- 75% of observed tumors are thymic lymphomas
- most lymphomas are thymic lymphomas

skeleton phenotype

increased osteosarcoma incidence
- 13% incidence

muscle phenotype

increased rhabdomyosarcoma incidence

mortality/aging

premature death
- 90% succumb to tumors and die by 7 months of age
- average life span 160 days
- homozygous mutants die between ~50 to 250 days after birth
- most die by 6 months of age

preweaning lethality, incomplete penetrance
- 16.6% rather than the expected 25% of mutants are observed at weaning, indicating partial lethality either during embryogenesis or after birth but before weaning

neoplasm

increased T cell derived lymphoma incidence
- 75% of observed tumors are thymic lymphomas
- most lymphomas are thymic lymphomas

increased carcinoma incidence
- 3.3% incidence

increased fibrosarcoma incidence
- 13% incidence

increased hemangioma incidence
- 3.3% incidence

increased hemangiosarcoma incidence
- 20% incidence

increased lymphoma incidence
- 56% of homozygous nulls developed lymphomas
- 70% incidence
- 71% of mice develop lymphoma, usually affecting the thymus

increased osteosarcoma incidence
- 13% incidence

increased rhabdomyosarcoma incidence

increased sarcoma incidence
- 40% of homozygous nulls developed sarcomas
- 50% incidence

increased squamous cell carcinoma incidence
- 3.3% incidence of stomach squamous cell carcinoma

increased teratoma incidence

increased tumor incidence
- predominantly lymphomas with sarcomas and teratomas

cellular phenotype

abnormal apoptosis

aneuploidy

decreased cell proliferation
- in mouse embryonic fibroblasts treated with UV irradiation

decreased cellular sensitivity to gamma-irradiation
- irradiated E13.5 heterozygous embryos showed no evidence of apoptosis in the hypothalamus compared to wildtype and heterozygotes that showed a high number of apoptotic cells

decreased cellular sensitivity to ultraviolet irradiation
- in mouse embryonic fibroblasts

increased fibroblast proliferation
- MEFs initially did not show any significant differences in growth rate but by day 4, grew more rapidly than wildtype or heterozygous MEFs

digestive/alimentary phenotype

colon polyps
- 6.7% incidence

gastric polyps
- 3.3% incidence of stomach polyps

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas

mortality/aging

premature death
- animals die by about 26 weeks
- majority of mice (82%) die before 9 months of age, or are euthanized due to occurrence of obvious tumor mass
- mean life span is 4.4 months

prenatal lethality, incomplete penetrance
- a slight decrease is seen in the number of females born

nervous system phenotype

abnormal neuron differentiation
- GNPs from mutants show ~50% levels of proliferation compared to Cdkn2c, Trp53-double null cells after 3 days in culture and levels of cells incorporating BrdU are still less in single mutants in tests where cells are stimulated with Shh after culture

increased medulloblastoma incidence
- 13/19 (68%) of animals receiving 4 Gy radiation at P5 or 6 develop cerebellar tumors

neoplasm

increased T cell derived lymphoma incidence
- 6 of 10 mice develop thymic lymphomas
- 66% of homozygotes display hematological malignancies, primarily T cell lymphomas
- mice start to develop T cell malignancies at 14-16 weeks

increased hemangiosarcoma incidence
- the incidence of hemangiosarcomas is 32% compared to 62% in Trp53^tm1Tyj/Trp53^tm2.1Tyj mice

increased lymphoma incidence
- 3 of 10 mice develop lymphomas involving the spleen and lymph nodes

increased medulloblastoma incidence
- 13/19 (68%) of animals receiving 4 Gy radiation at P5 or 6 develop cerebellar tumors

increased tumor incidence
- 32% have multiple tumors

cellular phenotype

abnormal cell cycle checkpoint function
- gamma-irradiation fails to produce an increase in the relative number of cells in G1 compared to S phase
- mouse embryonic fibroblasts exposed to radiation fail to arrest at the G1/S transition unlike similarly treated wild-type cells

abnormal neuron differentiation
- GNPs from mutants show ~50% levels of proliferation compared to Cdkn2c, Trp53-double null cells after 3 days in culture and levels of cells incorporating BrdU are still less in single mutants in tests where cells are stimulated with Shh after culture

decreased T cell apoptosis
- thymocytes are essentially resistant to Trp53-mediated apoptosis

decreased cellular sensitivity to ultraviolet irradiation
- reduced sensitivity to UV-induced cell death in MEFs compared to wild-type cells

decreased splenocyte apoptosis
- in irradiated spleen cells

decreased thymocyte apoptosis
- in irradiated thymocytes
- in response to irradiation
- rare following exposure to ionizing radiation

increased fibroblast proliferation
- in MEFs

polyploidy
- after irradiation with UVC light, MEFs from null mice show higher levels of polyploidy than Trp53^tm2Xu homozygotes

immune system phenotype

decreased T cell apoptosis
- thymocytes are essentially resistant to Trp53-mediated apoptosis

decreased splenocyte apoptosis
- in irradiated spleen cells

decreased thymocyte apoptosis
- in irradiated thymocytes
- in response to irradiation
- rare following exposure to ionizing radiation

cardiovascular system phenotype

abnormal cardiovascular system physiology
- better systolic function than control

cardiac hypertrophy
- increased hypertrophy as a result of transverse aortic restriction

increased angiogenesis
- increased number of microvessels form 2 weeks after transverse aortic constriction

hematopoietic system phenotype

decreased T cell apoptosis
- thymocytes are essentially resistant to Trp53-mediated apoptosis

decreased splenocyte apoptosis
- in irradiated spleen cells

decreased thymocyte apoptosis
- in irradiated thymocytes
- in response to irradiation
- rare following exposure to ionizing radiation

endocrine/exocrine gland phenotype

decreased thymocyte apoptosis
- in irradiated thymocytes
- in response to irradiation
- rare following exposure to ionizing radiation

increased T cell derived lymphoma incidence
- 6 of 10 mice develop thymic lymphomas
- 66% of homozygotes display hematological malignancies, primarily T cell lymphomas
- mice start to develop T cell malignancies at 14-16 weeks

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
129S6.129-Trp53^tm1Tyj Rb1^tm1.1Jyjw

endocrine/exocrine gland phenotype

increased testicular teratoma incidence

reproductive system phenotype

increased testicular teratoma incidence

mortality/aging

premature death
- mice become moribund from lymphoma involving various tissues within >30 weeks; mice with aggressive lymphoma have a mean survival time of 18 weeks

neoplasm

increased lymphoma incidence
- mice develop lymphomas

increased teratoma incidence
- median survival time of mice with teratomas is 7 weeks
- no mice living beyond median survival age show extratesticular teratomas

increased testicular teratoma incidence

digestive/alimentary phenotype

intestinal ulcer
- after 7 days of dextran sodium sulfate treatment, mice develop large ulcers in the colon

growth/size/body region phenotype

weight loss
- with DSS treatment, double mutants have an average weight of 14% of body weight

References

Jacks T; Remington L; Williams BO; Schmitt EM; Halachmi S; Bronson RT; Weinberg RA. 1994. Tumor spectrum analysis in p53-mutant mice. Curr Biol 4(1):1-7. PubMed: 7922305 MGI: J:17728

Additional References

Aleyasin H; Cregan SP; Iyirhiaro G; O'Hare MJ; Callaghan SM; Slack RS; Park DS. 2004. Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage. J Neurosci 24(12):2963-73. PubMed: 15044535 MGI: J:90221
Botchkarev VA; Komarova EA; Siebenhaar F; Botchkareva NV; Komarov PG; Maurer M; Gilchrest BA; Gudkov AV. 2000. p53 is essential for chemotherapy-induced hair loss. Cancer Res 60(18):5002-6. PubMed: 11016618 MGI: J:64779
Cunningham JJ; Levine EM; Zindy F; Goloubeva O; Roussel MF; Smeyne RJ. 2002. The Cyclin-Dependent Kinase Inhibitors p19(Ink4d) and p27(Kip1) Are Coexpressed in Select Retinal Cells and Act Cooperatively to Control Cell Cycle Exit. Mol Cell Neurosci 19(3):359-74. PubMed: 11906209 MGI: J:75882
Fong LY; Ishii H; Nguyen VT; Vecchione A; Farber JL; Croce CM; Huebner K. 2003. p53 Deficiency Accelerates Induction and Progression of Esophageal and Forestomach Tumors in Zinc-deficient Mice. Cancer Res 63(1):186-95. PubMed: 12517797 MGI: J:81055
Freie B; Li X; Ciccone SL; Nawa K; Cooper S; Vogelweid C; Schantz L; Haneline LS; Orazi A; Broxmeyer HE; Lee SH; Clapp DW. 2003. Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis. Blood 102(12):4146-52. PubMed: 12855557 MGI: J:84980
Ikeda S; Hawes NL; Chang B; Avery CS; Smith RS; Nishina PM. 1999. Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice. Invest Ophthalmol Vis Sci 40(8):1874-8. PubMed: 10393064 MGI: J:55873
Ito M; Okano HJ; Darnell RB; Roeder RG. 2002. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J 21(13):3464-75. PubMed: 12093747 MGI: J:77765
Komarova EA; Christov K; Faerman AI; Gudkov AV. 2000. Different impact of p53 and p21 on the radiation response of mouse tissues. Oncogene 19(33):3791-8. PubMed: 10949934 MGI: J:63921
Komarova EA; Kondratov RV; Wang K; Christov K; Golovkina TV; Goldblum JR; Gudkov AV. 2004. Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene 23(19):3265-71. PubMed: 15064735 MGI: J:89739
Lowe SW; Schmitt EM; Smith SW; Osborne BA; Jacks T. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes [see comments] Nature 362(6423):847-9. PubMed: 8479522 MGI: J:16022
Lu YP; Lou YR; Peng QY; Xie JG; Conney AH. 2004. Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice. Cancer Res 64(14):5020-7. PubMed: 15256477 MGI: J:91506
McCarthy EE; Celebi JT; Baer R; Ludwig T. 2003. Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. Mol Cell Biol 23(14):5056-63. PubMed: 12832489 MGI: J:84329
McGlynn KA; Hunter K; LeVoyer T; Roush J; Wise P; Michielli RA; Shen FM; Evans AA; London WT; Buetow KH. 2003. Susceptibility to aflatoxin B1-related primary hepatocellular carcinoma in mice and humans. Cancer Res 63(15):4594-601. PubMed: 12907637 MGI: J:85696
Opitz OG; Harada H; Suliman Y; Rhoades B; Sharpless NE; Kent R; Kopelovich L; Nakagawa H; Rustgi AK. 2002. A mouse model of human oral-esophageal cancer. J Clin Invest 110(6):761-9. PubMed: 12235107 MGI: J:79110
Reilly KM; Loisel DA; Bronson RT; McLaughlin ME; Jacks T. 2000. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects Nat Genet 26(1):109-13. PubMed: 10973261 MGI: J:64364
Sah VP; Attardi LD; Mulligan GJ; Williams BO; Bronson RT; Jacks T. 1995. A subset of p53-deficient embryos exhibit exencephaly. Nat Genet 10(2):175-80. PubMed: 7663512 MGI: J:23197
Sata M; Tanaka K; Ishizaka N; Hirata Y; Nagai R. 2003. Absence of p53 Leads to Accelerated Neointimal Hyperplasia After Vascular Injury. Arterioscler Thromb Vasc Biol 23(9):1548-52. PubMed: 12893686 MGI: J:84981
Scoggins CR; Meszoely IM; Wada M; Means AL; Yang L; Leach SD. 2000. p53-dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas Am J Physiol Gastrointest Liver Physiol 279(5):G827-36. PubMed: 11005771 MGI: J:65224
Takeda K; Smyth MJ; Cretney E; Hayakawa Y; Kayagaki N; Yagita H; Okumura K. 2002. Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J Exp Med 195(2):161-9. PubMed: 11805143 MGI: J:74411
Verschuren EW; Hodgson JG; Gray JW; Kogan S; Jones N; Evan GI. 2004. The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis. Cancer Res 64(2):581-9. PubMed: 14744772 MGI: J:88091
Weber GF; Bronson RT; Ilagan J; Cantor H; Schmits R; Mak TW. 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res 62(8):2281-6. PubMed: 11956084 MGI: J:76201
Wen R; Wang D; McKay C; Bunting KD; Marine JC; Vanin EF; Zambetti GP; Korsmeyer SJ; Ihle JN; Cleveland JL. 2001. Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development. Mol Cell Biol 21(2):678-89. PubMed: 11134353 MGI: J:67378
Yamanishi Y; Boyle DL; Pinkoski MJ; Mahboubi A; Lin T; Han Z; Zvaifler NJ; Green DR; Firestein GS. 2002. Regulation of Joint Destruction and Inflammation by p53 in Collagen-Induced Arthritis. Am J Pathol 160(1):123-30. PubMed: 11786406 MGI: J:73730
Yang X; Klein R; Tian X; Cheng HT; Kopan R; Shen J. 2004. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol 269(1):81-94. PubMed: 15081359 MGI: J:90392

Additional - Trp53^tm1Tyj related

Aarabi S; Bhatt KA; Shi Y; Paterno J; Chang EI; Loh SA; Holmes JW; Longaker MT; Yee H; Gurtner GC. 2007. Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J 21(12):3250-61. PubMed: 17504973 MGI: J:143834
Ablamunits V; Cohen Y; Brazee IB; Gaetz HP; Vinson C; Klebanov S. 2006. Susceptibility to Induced and Spontaneous Carcinogenesis Is Increased in Fatless A-ZIP/F-1 but not in Obese ob/ob Mice. Cancer Res 66(17):8897-902. PubMed: 16951207 MGI: J:112412
Adams CM; Eischen CM. 2014. Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer. Cancer Res 74(14):3923-34. PubMed: 24840646 MGI: J:213117
Adriaens C; Standaert L; Barra J; Latil M; Verfaillie A; Kalev P; Boeckx B; Wijnhoven PW; Radaelli E; Vermi W; Leucci E; Lapouge G; Beck B; van den Oord J; Nakagawa S; Hirose T; Sablina AA; Lambrechts D; Aerts S; Blanpain C; Marine JC. 2016. p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat Med 22(8):861-8. PubMed: 27376578 MGI: J:240137
Aggarwal P; Lessie MD; Lin DI; Pontano L; Gladden AB; Nuskey B; Goradia A; Wasik MA; Klein-Szanto AJ; Rustgi AK; Bassing CH; Diehl JA. 2007. Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev 21(22):2908-22. PubMed: 18006686 MGI: J:127316
Aghi M; Cohen KS; Klein RJ; Scadden DT; Chiocca EA. 2006. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res 66(18):9054-64. PubMed: 16982747 MGI: J:112935
Ahkter S; Richie CT; Zhang N; Behringer RR; Zhu C; Legerski RJ. 2005. Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Mol Cell Biol 25(22):10071-8. PubMed: 16260620 MGI: J:102381
Ahronian LG; Zhu LJ; Chen YW; Chu HC; Klimstra DS; Lewis BC. 2016. A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination. Oncogene :. PubMed: 26876204 MGI: J:230812
Akala OO; Park IK; Qian D; Pihalja M; Becker MW; Clarke MF. 2008. Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors. Nature 453(7192):228-32. PubMed: 18418377 MGI: J:134785
Akhter S; Lam YC; Chang S; Legerski RJ. 2010. The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development. Aging Cell 9(6):1047-56. PubMed: 20854421 MGI: J:217052
Al-Massadi O; Porteiro B; Kuhlow D; Kohler M; Gonzalez-Rellan MJ; Garcia-Lavandeira M; Diaz-Rodriguez E; Quinones M; Senra A; Alvarez CV; Lopez M; Dieguez C; Schulz TJ; Nogueiras R. 2016. Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice. Endocrinology 157(7):2735-49. PubMed: 27183316 MGI: J:239719
Alexandrova EM; Petrenko O; Nemajerova A; Romano RA; Sinha S; Moll UM. 2013. DeltaNp63 regulates select routes of reprogramming via multiple mechanisms. Cell Death Differ 20(12):1698-708. PubMed: 24013722 MGI: J:228996
Almeida MQ; Muchow M; Boikos S; Bauer AJ; Griffin KJ; Tsang KM; Cheadle C; Watkins T; Wen F; Starost MF; Bossis I; Nesterova M; Stratakis CA. 2010. Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling. Hum Mol Genet 19(8):1387-98. PubMed: 20080939 MGI: J:158372
Alt JR; Greiner TC; Cleveland JL; Eischen CM. 2003. Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J 22(6):1442-50. PubMed: 12628936 MGI: J:82477
Alvarez JV; Pan TC; Ruth J; Feng Y; Zhou A; Pant D; Grimley JS; Wandless TJ; Demichele A; Chodosh LA. 2013. Par-4 Downregulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy. Cancer Cell 24(1):30-44. PubMed: 23770012 MGI: J:199068
Amlin-Van Schaick JC; Kim S; DiFabio C; Lee MH; Broman KW; Reilly KM. 2012. Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12. Neuro Oncol 14(2):160-74. PubMed: 22234937 MGI: J:186764
Amrani YM; Gill J; Matevossian A; Alonzo ES; Yang C; Shieh JH; Moore MA; Park CY; Sant'Angelo DB; Denzin LK. 2011. The Paf oncogene is essential for hematopoietic stem cell function and development. J Exp Med 208(9):1757-65. PubMed: 21844206 MGI: J:177782
Apostolidis PA; Woulfe DS; Chavez M; Miller WM; Papoutsakis ET. 2012. Role of tumor suppressor p53 in megakaryopoiesis and platelet function. Exp Hematol 40(2):131-42.e4. PubMed: 22024107 MGI: J:191403
Arendt LM; Rugowski DE; Grafwallner-Huseth TA; Garcia-Barchino MJ; Rui H; Schuler LA. 2011. Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer. Breast Cancer Res 13(1):R11. PubMed: 21276249 MGI: J:173131
Artandi SE; Chang S; Lee SL; Alson S; Gottlieb GJ; Chin L; DePinho RA. 2000. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [see comments] Nature 406(6796):641-5. PubMed: 10949306 MGI: J:63843
Asai T; Liu Y; Di Giandomenico S; Bae N; Ndiaye-Lobry D; Deblasio A; Menendez S; Antipin Y; Reva B; Wevrick R; Nimer SD. 2012. Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells. Blood 120(8):1601-12. PubMed: 22776820 MGI: J:189173
Asakura A; Rudnicki MA. 2003. Rhabdomyosarcomagenesis-Novel pathway found. Cancer Cell 4(6):421-2. PubMed: 14706332 MGI: J:88121
Aslanian A; Iaquinta PJ; Verona R; Lees JA. 2004. Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev 18(12):1413-22. PubMed: 15175242 MGI: J:90855
Atanassov BS; Evrard YA; Multani AS; Zhang Z; Tora L; Devys D; Chang S; Dent SY. 2009. Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell 35(3):352-64. PubMed: 19683498 MGI: J:154202
Ayanga B; Price R; Gu X; Lozano G; Evans SC. 2006. Genetic mapping of a putative tumor suppressor locus that influences tumorigenesis and metastasis in mice. Genes Chromosomes Cancer 45(7):668-75. PubMed: 16586494 MGI: J:108788
Bachy E; Urb M; Chandra S; Robinot R; Bricard G; de Bernard S; Traverse-Glehen A; Gazzo S; Blond O; Khurana A; Baseggio L; Heavican T; Ffrench M; Crispatzu G; Mondiere P; Schrader A; Taillardet M; Thaunat O; Martin N; Dalle S; Le Garff-Tavernier M; Salles G; Lachuer J; Hermine O; Asnafi V; Roussel M; Lamy T; Herling M; Iqbal J; Buffat L; Marche PN; Gaulard P; Kronenberg M; Defrance T; Genestier L. 2016. CD1d-restricted peripheral T cell lymphoma in mice and humans. J Exp Med 213(5):841-57. PubMed: 27069116 MGI: J:233315
Backlund MG; Trasti SL; Backlund DC; Cressman VL; Godfrey V; Koller BH. 2001. Impact of ionizing radiation and genetic background on mammary tumorigenesis in p53-deficient mice. Cancer Res 61(17):6577-82. PubMed: 11522657 MGI: J:71052
Baek KH; Shin HJ; Yoo JK; Cho JH; Choi YH; Sung YC; McKeon F; Lee CW. 2003. p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest. J Leukoc Biol 73(6):850-61. PubMed: 12773518 MGI: J:121196
Bailey DP; Kashyap M; Bouton LA; Murray PJ; Ryan JJ. 2006. Interleukin-10 induces apoptosis in developing mast cells and macrophages. J Leukoc Biol 80(3):581-9. PubMed: 16829633 MGI: J:112579
Baker DJ; Jin F; Jeganathan KB; van Deursen JM. 2009. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 16(6):475-86. PubMed: 19962666 MGI: J:155824
Baker DJ; Weaver RL; van Deursen JM. 2013. p21 both attenuates and drives senescence and aging in BubR1 progeroid mice. Cell Rep 3(4):1164-74. PubMed: 23602569 MGI: J:198507
Bakthavatchalu V; Dey S; Xu Y; Noel T; Jungsuwadee P; Holley AK; Dhar SK; Batinic-Haberle I; St Clair DK. 2012. Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polgamma against UV-induced inactivation. Oncogene 31(17):2129-39. PubMed: 21909133 MGI: J:190273
Baldauf C; Jeschke A; Kanbach V; Catala-Lehnen P; Baumhoer D; Gerull H; Buhs S; Amling M; Nollau P; Harroch S; Schinke T. 2015. The Protein Tyrosine Phosphatase Rptpzeta Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice. PLoS One 10(9):e0137745. PubMed: 26360410 MGI: J:243104
Balsitis S; Dick F; Lee D; Farrell L; Hyde RK; Griep AE; Dyson N; Lambert PF. 2005. Examination of the pRb-dependent and pRb-independent functions of E7 in vivo. J Virol 79(17):11392-402. PubMed: 16103190 MGI: J:101623
Banerjee A; Thyagarajan K; Chatterjee S; Chakraborty P; Kesarwani P; Soloshchenko M; Al-Hommrani M; Andrijauskaite K; Moxley K; Janakiraman H; Scheffel MJ; Helke K; Armenson K; Palanisamy V; Rubinstein MP; Mayer EG; Cole DJ; Paulos CM; Voelkel-Johnson C; Nishimura MI; Mehrotra S. 2016. Lack of p53 Augments Antitumor Functions in Cytolytic T Cells. Cancer Res 76(18):5229-40. PubMed: 27466285 MGI: J:235134
Barabino A; Plamondon V; Abdouh M; Chatoo W; Flamier A; Hanna R; Zhou S; Motoyama N; Hebert M; Lavoie J; Bernier G. 2016. Loss of Bmi1 causes anomalies in retinal development and degeneration of cone photoreceptors. Development 143(9):1571-84. PubMed: 26965367 MGI: J:235536
Barboza JA; Iwakuma T; Terzian T; El-Naggar AK; Lozano G. 2008. Mdm2 and Mdm4 loss regulates distinct p53 activities. Mol Cancer Res 6(6):947-54. PubMed: 18567799 MGI: J:139880
Barboza JA; Liu G; Ju Z; El-Naggar AK; Lozano G. 2006. p21 delays tumor onset by preservation of chromosomal stability. Proc Natl Acad Sci U S A 103(52):19842-7. PubMed: 17170138 MGI: J:118255
Bardeesy N; Bastian BC; Hezel A; Pinkel D; DePinho RA; Chin L. 2001. Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Mol Cell Biol 21(6):2144-53. PubMed: 11238948 MGI: J:67799
Bardeesy N; Morgan J; Sinha M; Signoretti S; Srivastava S; Loda M; Merlino G; DePinho RA. 2002. Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia. Mol Cell Biol 22(2):635-43. PubMed: 11756558 MGI: J:73973
Barkic M; Crnomarkovic S; Grabusic K; Bogetic I; Panic L; Tamarut S; Cokaric M; Jeric I; Vidak S; Volarevic S. 2009. The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival. Mol Cell Biol 29(10):2489-504. PubMed: 19273598 MGI: J:148991
Barlow C; Brown KD; Deng CX; Tagle DA; Wynshaw-Boris A. 1997. Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways. Nat Genet 17(4):453-6. PubMed: 9398849 MGI: J:76690
Barlow C; Liyanage M; Moens PB; Deng CX; Ried T; Wynshaw-Boris A. 1997. Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles. Nat Genet 17(4):462-6. PubMed: 9398851 MGI: J:44388
Barone E; Cenini G; Di Domenico F; Noel T; Wang C; Perluigi M; St Clair DK; Butterfield DA. 2015. Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53. J Neurosci Res 93(11):1728-39. PubMed: 26251011 MGI: J:238598
Bazzi H; Anderson KV. 2014. Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A 111(15):E1491-500. PubMed: 24706806 MGI: J:208632
Becker KA; Lu S; Dickinson ES; Dunphy KA; Mathews L; Schneider SS; Jerry DJ. 2005. Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-beta-dependent pathways. Oncogene 24(42):6345-53. PubMed: 15940247 MGI: J:101763
Beekman C; Nichane M; De Clercq S; Maetens M; Floss T; Wurst W; Bellefroid E; Marine JC. 2006. Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development. Mol Cell Biol 26(24):9291-301. PubMed: 17000755 MGI: J:118144
Bekaert S; Derradji H; Meyer TD; Michaux A; Buset J; Neefs M; Mergeay M; Jacquet P; Van Oostveldt P; Baatout S. 2005. Telomere shortening is associated with malformation in p53-deficient mice after irradiation during specific stages of development. DNA Repair (Amst) 4(9):1028-37. PubMed: 15990362 MGI: J:105007
Belle JI; Langlais D; Petrov JC; Pardo M; Jones RG; Gros P; Nijnik A. 2015. p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency. Blood 125(15):2344-8. PubMed: 25710881 MGI: J:222019
Belle JI; Petrov JC; Langlais D; Robert F; Cencic R; Shen S; Pelletier J; Gros P; Nijnik A. 2016. Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance. Cell Death Differ 23(5):759-75. PubMed: 26768662 MGI: J:235706
Bender CF; Sikes ML; Sullivan R; Huye LE; Le Beau MM; Roth DB; Mirzoeva OK; Oltz EM; Petrini JH. 2002. Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev 16(17):2237-51. PubMed: 12208847 MGI: J:78820
Berges RR; Furuya Y; Remington L; English HF; Jacks T; Isaacs JT. 1993. Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation. Proc Natl Acad Sci U S A 90(19):8910-4. PubMed: 8415631 MGI: J:111328
Berman DM; Karhadkar SS; Hallahan AR; Pritchard JI; Eberhart CG; Watkins DN; Chen JK; Cooper MK; Taipale J; Olson JM; Beachy PA. 2002. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297(5586):1559-61. PubMed: 12202832 MGI: J:79798
Bertout JA; Patel SA; Fryer BH; Durham AC; Covello KL; Olive KP; Goldschmidt MH; Simon MC. 2009. Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model. Cancer Res 69(7):3213-20. PubMed: 19293180 MGI: J:147359
Beumer TL; Roepers-Gajadien HL; Gademan IS; van Buul PP; Gil-Gomez G; Rutgers DH; de Rooij DG. 1998. The role of the tumor suppressor p53 in spermatogenesis. Cell Death Differ 5(8):669-77. PubMed: 10200522 MGI: J:114210
Bildsoe H; Loebel DA; Jones VJ; Hor AC; Braithwaite AW; Chen YT; Behringer RR; Tam PP. 2013. The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function. Dev Biol 374(2):295-307. PubMed: 23261931 MGI: J:193413
Blackburn AC; Brown JS; Naber SP; Otis CN; Wood JT; Jerry DJ. 2003. BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice. Cancer Res 63(10):2364-8. PubMed: 12750252 MGI: J:83496
Blackburn AC; Hill LZ; Roberts AL; Wang J; Aud D; Jung J; Nikolcheva T; Allard J; Peltz G; Otis CN; Cao QJ; Ricketts RS; Naber SP; Mollenhauer J; Poustka A; Malamud D; Jerry DJ. 2007. Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk. Am J Pathol 170(6):2030-41. PubMed: 17525270 MGI: J:122161
Blackburn AC; McLary SC; Naeem R; Luszcz J; Stockton DW; Donehower LA; Mohammed M; Mailhes JB; Soferr T; Naber SP; Otis CN; Jerry DJ. 2004. Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain. Cancer Res 64(15):5140-7. PubMed: 15289317 MGI: J:91874
Blanco-Aparicio C; Canamero M; Cecilia Y; Pequeno B; Renner O; Ferrer I; Carnero A. 2010. Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models. PLoS One 5(2):e9305. PubMed: 20174572 MGI: J:157988
Blin-Wakkach C; Breuil V; Quincey D; Bagnis C; Carle GF. 2006. Establishment and characterization of new osteoclast progenitor cell lines derived from osteopetrotic and wild type mice. Bone 39(1):53-60. PubMed: 16503212 MGI: J:111156
Blough MD; Zlatescu MC; Cairncross JG. 2007. O6-methylguanine-DNA methyltransferase regulation by p53 in astrocytic cells. Cancer Res 67(2):580-4. PubMed: 17234766 MGI: J:117421
Boesten LS; Zadelaar SM; De Clercq S; Francoz S; van Nieuwkoop A; Biessen EA; Hofmann F; Feil S; Feil R; Jochemsen AG; Zurcher C; Havekes LM; van Vlijmen BJ; Marine JC. 2006. Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death. Cell Death Differ 13(12):2089-98. PubMed: 16729027 MGI: J:132251
Bolcun-Filas E; Rinaldi VD; White ME; Schimenti JC. 2014. Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway. Science 343(6170):533-6. PubMed: 24482479 MGI: J:207474
Bondar T; Medzhitov R. 2010. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6(4):309-22. PubMed: 20362536 MGI: J:158953
Borges HL; Bird J; Wasson K; Cardiff RD; Varki N; Eckmann L; Wang JY. 2005. Tumor promotion by caspase-resistant retinoblastoma protein. Proc Natl Acad Sci U S A 102(43):15587-92. PubMed: 16227443 MGI: J:102483
Bortner DM; Rosenberg MP. 1997. Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E. Mol Cell Biol 17(1):453-9. PubMed: 8972226 MGI: J:56329
Botchkarev VA; Komarova EA; Siebenhaar F; Botchkareva NV; Komarov PG; Maurer M; Gilchrest BA; Gudkov AV. 2000. p53 is essential for chemotherapy-induced hair loss. Cancer Res 60(18):5002-6. PubMed: 11016618 MGI: J:64779
Botchkarev VA; Komarova EA; Siebenhaar F; Botchkareva NV; Sharov AA; Komarov PG; Maurer M; Gudkov AV; Gilchrest BA. 2001. p53 Involvement in the control of murine hair follicle regression. Am J Pathol 158(6):1913-9. PubMed: 11395365 MGI: J:108257
Bouchard C; Lee S; Paulus-Hock V; Loddenkemper C; Eilers M; Schmitt CA. 2007. FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. Genes Dev 21(21):2775-87. PubMed: 17974917 MGI: J:126308
Bowman T; Symonds H; Gu L; Yin C; Oren M; Van Dyke T. 1996. Tissue-specific inactivation of p53 tumor suppression in the mouse. Genes Dev 10(7):826-35. PubMed: 8846919 MGI: J:54288
Brichkina A; Bertero T; Loh HM; Nguyen NT; Emelyanov A; Rigade S; Ilie M; Hofman P; Gaggioli C; Bulavin DV. 2016. p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis. Genes Dev 30(23):2623-2636. PubMed: 28007785 MGI: J:237913
Brochier C; Dennis G; Rivieccio MA; McLaughlin K; Coppola G; Ratan RR; Langley B. 2013. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. J Neurosci 33(20):8621-32. PubMed: 23678107 MGI: J:198424
Bruins W; Bruning O; Jonker MJ; Zwart E; van der Hoeven TV; Pennings JL; Rauwerda H; de Vries A; Breit TM. 2008. The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse embryonic fibroblasts. Mol Cell Biol 28(6):1974-87. PubMed: 18195040 MGI: J:132668
Bu P; Evrard YA; Lozano G; Dent SY. 2007. Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol 27(9):3405-16. PubMed: 17325035 MGI: J:121357
Buchstaller J; McKeever PE; Morrison SJ. 2012. Tumorigenic Cells Are Common in Mouse MPNSTs but Their Frequency Depends upon Tumor Genotype and Assay Conditions. Cancer Cell 21(2):240-52. PubMed: 22340596 MGI: J:181460
Bullitt E; Wolthusen PA; Brubaker L; Lin W; Zeng D; Van Dyke T. 2006. Malignancy-associated vessel tortuosity: a computer-assisted, MR angiographic study of choroid plexus carcinoma in genetically engineered mice. AJNR Am J Neuroradiol 27(3):612-9. PubMed: 16552004 MGI: J:110646
Busuttil V; Droin N; McCormick L; Bernassola F; Candi E; Melino G; Green DR. 2010. NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2. Proc Natl Acad Sci U S A 107(42):18061-6. PubMed: 20921405 MGI: J:165536
Cai KQ; Wang Y; Smith ER; Smedberg JL; Yang DH; Yang WL; Xu XX. 2015. Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice. Neoplasia 17(1):89-100. PubMed: 25622902 MGI: J:244442
Camargo Moreno M; Mooney SM; Middleton FA. 2017. Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder. PLoS One 12(7):e0180873. PubMed: 28723918 MGI: J:248519
Camboni M; Hammond S; Martin LT; Martin PT. 2012. Induction of a regenerative microenvironment in skeletal muscle is sufficient to induce embryonal rhabdomyosarcoma in p53-deficient mice. J Pathol 226(1):40-9. PubMed: 21915858 MGI: J:180024
Campana AL; Rondi-Reig L; Tobin C; Lohof AM; Picquet F; Falempin M; Weitzman JB; Mariani J. 2003. p53 inactivation leads to impaired motor synchronization in mice. Eur J Neurosci 17(10):2135-46. PubMed: 12786980 MGI: J:89637
Cancino GI; Yiu AP; Fatt MP; Dugani CB; Flores ER; Frankland PW; Josselyn SA; Miller FD; Kaplan DR. 2013. p63 Regulates Adult Neural Precursor and Newly Born Neuron Survival to Control Hippocampal-Dependent Behavior. J Neurosci 33(31):12569-85. PubMed: 23904595 MGI: J:199784
Cang Y; Zhang J; Nicholas SA; Bastien J; Li B; Zhou P; Goff SP. 2006. Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Cell 127(5):929-40. PubMed: 17129780 MGI: J:117820
Cang Y; Zhang J; Nicholas SA; Kim AL; Zhou P; Goff SP. 2007. DDB1 is essential for genomic stability in developing epidermis. Proc Natl Acad Sci U S A 104(8):2733-7. PubMed: 17301228 MGI: J:125911
Cano CE; Gommeaux J; Pietri S; Culcasi M; Garcia S; Seux M; Barelier S; Vasseur S; Spoto RP; Pebusque MJ; Dusetti NJ; Iovanna JL; Carrier A. 2009. Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function. Cancer Res 69(1):219-26. PubMed: 19118006 MGI: J:143030
Caprio C; Baldini A. 2014. p53 suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome. Proc Natl Acad Sci U S A 111(37):13385-90. PubMed: 25197075 MGI: J:216364
Celli GB; de Lange T. 2005. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol 7(7):712-8. PubMed: 15968270 MGI: J:105516
Cellurale C; Weston CR; Reilly J; Garlick DS; Jerry DJ; Sluss HK; Davis RJ. 2010. Role of JNK in a Trp53-dependent mouse model of breast cancer. PLoS One 5(8):. PubMed: 20814571 MGI: J:163993
Ch'ang HJ; Maj JG; Paris F; Xing HR; Zhang J; Truman JP; Cardon-Cardo C; Haimovitz-Friedman A; Kolesnick R; Fuks Z. 2005. ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med 11(5):484-490. PubMed: 15864314 MGI: J:98312
Chand HS; Montano G; Huang X; Randell SH; Mebratu Y; Petersen H; Tesfaigzi Y. 2014. A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression. Nat Commun 5:5567. PubMed: 25429397 MGI: J:225704
Chao C; Herr D; Chun J; Xu Y. 2006. Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J 25(11):2615-22. PubMed: 16757976 MGI: J:109354
Charytonowicz E; Terry M; Coakley K; Telis L; Remotti F; Cordon-Cardo C; Taub RN; Matushansky I. 2012. PPARgamma agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma. J Clin Invest 122(3):886-98. PubMed: 22293175 MGI: J:184491
Chatoo W; Abdouh M; David J; Champagne MP; Ferreira J; Rodier F; Bernier G. 2009. The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity. J Neurosci 29(2):529-42. PubMed: 19144853 MGI: J:144496
Chaturvedi V; Sitailo LA; Qin JZ; Bodner B; Denning MF; Curry J; Zhang W; Brash D; Nickoloff BJ. 2005. Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosis. Oncogene 24(34):5299-312. PubMed: 15940268 MGI: J:100759
Chau JF; Jia D; Wang Z; Liu Z; Hu Y; Zhang X; Jia H; Lai KP; Leong WF; Au BJ; Mishina Y; Chen YG; Biondi C; Robertson E; Xie D; Liu H; He L; Wang X; Yu Q; Li B. 2012. A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response. Nat Commun 3:836. PubMed: 22588298 MGI: J:205636
Chavez-Reyes A; Parant JM; Amelse LL; de Oca Luna RM; Korsmeyer SJ; Lozano G. 2003. Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Res 63(24):8664-9. PubMed: 14695178 MGI: J:87065
Chen CM; Behringer RR. 2004. Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis. Genes Dev 18(3):320-32. PubMed: 14744934 MGI: J:88090
Chen D; Kon N; Zhong J; Zhang P; Yu L; Gu W. 2013. Differential Effects on ARF Stability by Normal versus Oncogenic Levels of c-Myc Expression. Mol Cell 51(1):46-56. PubMed: 23747016 MGI: J:199251
Chen D; Zheng W; Lin A; Uyhazi K; Zhao H; Lin H. 2012. Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis. Curr Biol 22(5):420-5. PubMed: 22342750 MGI: J:182280
Chen J; Li Y; Yu TS; McKay RM; Burns DK; Kernie SG; Parada LF. 2012. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488(7412):522-6. PubMed: 22854781 MGI: J:186769
Chen W; Cooper TK; Zahnow CA; Overholtzer M; Zhao Z; Ladanyi M; Karp JE; Gokgoz N; Wunder JS; Andrulis IL; Levine AJ; Mankowski JL; Baylin SB. 2004. Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell 6(4):387-98. PubMed: 15488761 MGI: J:94629
Cheng Y; Chikwava K; Wu C; Zhang H; Bhagat A; Pei D; Choi JK; Tong W. 2016. LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. J Clin Invest 126(4):1267-81. PubMed: 26974155 MGI: J:234661
Cheo DL; Meira LB; Burns DK; Reis AM; Issac T; Friedberg EC. 2000. Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors Cancer Res 60(6):1580-4. PubMed: 10749126 MGI: J:61421
Cheo DL; Meira LB; Hammer RE; Burns DK; Doughty AT; Friedberg EC. 1996. Synergistic interactions between XPC and p53 mutations in double-mutant mice: neural tube abnormalities and accelerated UV radiation-induced skin cancer. Curr Biol 6(12):1691-4. PubMed: 8994835 MGI: J:103622
Cheung CC; Yang C; Berger T; Zaugg K; Reilly P; Elia AJ; Wakeham A; You-Ten A; Chang N; Li L; Wan Q; Mak TW. 2010. Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABAA receptors. Proc Natl Acad Sci U S A 107(26):11883-8. PubMed: 20543135 MGI: J:161372
Chi YH; Ward JM; Cheng LI; Yasunaga J; Jeang KT. 2009. Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice. Int J Cancer 124(6):1483-9. PubMed: 19065665 MGI: J:147512
Chiang YJ; Difilippantonio MJ; Tessarollo L; Morse HC; Hodes RJ. 2012. Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas. PLoS One 7(11):e49305. PubMed: 23166633 MGI: J:195018
Chin L; Artandi SE; Shen Q; Tam A; Lee SL; Gottlieb GJ; Greider CW; DePinho RA. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97(4):527-38. PubMed: 10338216 MGI: J:54988
Cichowski K; Shih TS; Schmitt E; Santiago S; Reilly K; McLaughlin ME; Bronson RT; Jacks T. 1999. Mouse models of tumor development in neurofibromatosis type 1. Science 286(5447):2172-6. PubMed: 10591652 MGI: J:58876
Clegg HV; Itahana Y; Itahana K; Ramalingam S; Zhang Y. 2012. Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction. PLoS One 7(5):e38212. PubMed: 22666487 MGI: J:187290
Collins MA; Bednar F; Zhang Y; Brisset JC; Galban S; Galban CJ; Rakshit S; Flannagan KS; Adsay NV; Pasca di Magliano M. 2012. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest 122(2):639-53. PubMed: 22232209 MGI: J:184378
Colombo E; Bonetti P; Lazzerini Denchi E; Martinelli P; Zamponi R; Marine JC; Helin K; Falini B; Pelicci PG. 2005. Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol 25(20):8874-86. PubMed: 16199867 MGI: J:101353
Concepcion CP; Han YC; Mu P; Bonetti C; Yao E; D'Andrea A; Vidigal JA; Maughan WP; Ogrodowski P; Ventura A. 2012. Intact p53-dependent responses in miR-34-deficient mice. PLoS Genet 8(7):e1002797. PubMed: 22844244 MGI: J:188152
Conde C; Mark M; Oliver FJ; Huber A; de Murcia G; Menissier-de Murcia J. 2001. Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice. EMBO J 20(13):3535-43. PubMed: 11432840 MGI: J:70350
Cookman CJ; Belcher SM. 2015. Estrogen Receptor-beta Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology 156(7):2395-408. PubMed: 25885794 MGI: J:224638
Cooks T; Pateras IS; Tarcic O; Solomon H; Schetter AJ; Wilder S; Lozano G; Pikarsky E; Forshew T; Rozenfeld N; Harpaz N; Itzkowitz S; Harris CC; Rotter V; Gorgoulis VG; Oren M. 2013. Mutant p53 prolongs NF-kappaB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell 23(5):634-46. PubMed: 23680148 MGI: J:199005
Corno D; Pala M; Cominelli M; Cipelletti B; Leto K; Croci L; Barili V; Brandalise F; Melzi R; Di Gregorio A; Sergi LS; Politi LS; Piemonti L; Bulfone A; Rossi P; Rossi F; Consalez GG; Poliani PL; Galli R. 2012. Gene signatures associated with mouse postnatal hindbrain neural stem cells and medulloblastoma cancer stem cells identify novel molecular mediators and predict human medulloblastoma molecular classification. Cancer Discov 2(6):554-68. PubMed: 22628409 MGI: J:193066
Coschi CH; Martens AL; Ritchie K; Francis SM; Chakrabarti S; Berube NG; Dick FA. 2010. Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive. Genes Dev 24(13):1351-63. PubMed: 20551166 MGI: J:161363
Cottle DL; Kretzschmar K; Schweiger PJ; Quist SR; Gollnick HP; Natsuga K; Aoyagi S; Watt FM. 2013. c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis. Cell Rep 3(2):427-41. PubMed: 23403291 MGI: J:196301
Couto SS; Cao M; Duarte PC; Banach-Petrosky W; Wang S; Romanienko P; Wu H; Cardiff RD; Abate-Shen C; Cunha GR. 2009. Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer. Differentiation 77(1):103-11. PubMed: 19281769 MGI: J:147066
Coxon AB; Ward JM; Geradts J; Otterson GA; Zajac-Kaye M; Kaye FJ. 1998. RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer. Oncogene 17(12):1625-8. PubMed: 9794240 MGI: J:50139
Cressman VL; Backlund DC; Hicks EM; Gowen LC; Godfrey V; Koller BH. 1999. Mammary tumor formation in p53- and BRCA1-deficient mice. Cell Growth Differ 10(1):1-10. PubMed: 9950212 MGI: J:52011
Croci S; Landuzzi L; Nicoletti G; Palladini A; Antognoli A; De Giovanni C; Nanni P; Lollini PL. 2007. Expression of connective tissue growth factor (CTGF/CCN2) in a mouse model of rhabdomyosarcomagenesis. Pathol Oncol Res 13(4):336-9. PubMed: 18158569 MGI: J:133412
Croci S; Nicoletti G; Landuzzi L; De Giovanni C; Astolfi A; Marini C; Di Carlo E; Musiani P; Forni G; Nanni P; Lollini PL. 2004. Immunological prevention of a multigene cancer syndrome. Cancer Res 64(22):8428-34. PubMed: 15548714 MGI: J:93904
Crowther AJ; Gama V; Bevilacqua A; Chang SX; Yuan H; Deshmukh M; Gershon TR. 2013. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci 33(46):18098-108. PubMed: 24227720 MGI: J:204171
Cunningham JJ; Levine EM; Zindy F; Goloubeva O; Roussel MF; Smeyne RJ. 2002. The Cyclin-Dependent Kinase Inhibitors p19(Ink4d) and p27(Kip1) Are Coexpressed in Select Retinal Cells and Act Cooperatively to Control Cell Cycle Exit. Mol Cell Neurosci 19(3):359-74. PubMed: 11906209 MGI: J:75882
Curtis DJ; Robb L; Strasser A; Begley CG. 1997. The CD2-scl transgene alters the phenotype and frequency of T-lymphomas in N-ras transgenic or p53 deficient mice. Oncogene 15(24):2975-83. PubMed: 9416841 MGI: J:93511
Dackor J; Strunk KE; Wehmeyer MM; Threadgill DW. 2007. Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos. Placenta 28(11-12):1211-8. PubMed: 17822758 MGI: J:141339
Dai C; Santagata S; Tang Z; Shi J; Cao J; Kwon H; Bronson RT; Whitesell L; Lindquist S. 2012. Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest 122(10):3742-54. PubMed: 22945628 MGI: J:191670
Darr J; Klochendler A; Isaac S; Eden A. 2014. Loss of IGFBP7 expression and persistent AKT activation contribute to SMARCB1/Snf5-mediated tumorigenesis. Oncogene 33(23):3024-32. PubMed: 23851500 MGI: J:212579
David G; Dannenberg JH; Simpson N; Finnerty PM; Miao L; Turner GM; Ding Z; Carrasco R; Depinho RA. 2006. Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53. Oncogene 25(56):7354-60. PubMed: 16767157 MGI: J:117829
Davis DW; Weidner DA; Holian A; McConkey DJ. 2000. Nitric oxide-dependent activation of p53 suppresses bleomycin-induced apoptosis in the lung. J Exp Med 192(6):857-69. PubMed: 10993916 MGI: J:112014
De Lisle RC; Xu W; Roe BA; Ziemer D. 2008. Effects of Muclin (Dmbt1) deficiency on the gastrointestinal system. Am J Physiol Gastrointest Liver Physiol 294(3):G717-27. PubMed: 18202109 MGI: J:132597
De Raedt T; Beert E; Pasmant E; Luscan A; Brems H; Ortonne N; Helin K; Hornick JL; Mautner V; Kehrer-Sawatzki H; Clapp W; Bradner J; Vidaud M; Upadhyaya M; Legius E; Cichowski K. 2014. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature 514(7521):247-51. PubMed: 25119042 MGI: J:217077
De Raedt T; Walton Z; Yecies JL; Li D; Chen Y; Malone CF; Maertens O; Jeong SM; Bronson RT; Lebleu V; Kalluri R; Normant E; Haigis MC; Manning BD; Wong KK; Macleod KF; Cichowski K. 2011. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell 20(3):400-13. PubMed: 21907929 MGI: J:175966
De la Cueva E; Garcia-Cao I; Herranz M; Lopez P; Garcia-Palencia P; Flores JM; Serrano M; Fernandez-Piqueras J; Martin-Caballero J. 2006. Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma. Oncogene 25(29):4128-32. PubMed: 16462758 MGI: J:112294
Debies MT; Gestl SA; Mathers JL; Mikse OR; Leonard TL; Moody SE; Chodosh LA; Cardiff RD; Gunther EJ. 2008. Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss. J Clin Invest 118(1):51-63. PubMed: 18060046 MGI: J:130828
Delbridge AR; Pang SH; Vandenberg CJ; Grabow S; Aubrey BJ; Tai L; Herold MJ; Strasser A. 2016. RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice. J Exp Med 213(10):2039-48. PubMed: 27621418 MGI: J:237272
Delgado-Esteban M; Garcia-Higuera I; Maestre C; Moreno S; Almeida A. 2013. APC/C-Cdh1 coordinates neurogenesis and cortical size during development. Nat Commun 4:2879. PubMed: 24301314 MGI: J:206142
Denchi EL. 2009. Give me a break: How telomeres suppress the DNA damage response. DNA Repair (Amst) 8(9):1118-26. PubMed: 19482563 MGI: J:151432
Deriano L; Chaumeil J; Coussens M; Multani A; Chou Y; Alekseyenko AV; Chang S; Skok JA; Roth DB. 2011. The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature 471(7336):119-23. PubMed: 21368836 MGI: J:170462
Deshpande SD; Putta S; Wang M; Lai JY; Bitzer M; Nelson RG; Lanting LL; Kato M; Natarajan R. 2013. Transforming growth factor-beta-induced cross talk between p53 and a microRNA in the pathogenesis of diabetic nephropathy. Diabetes 62(9):3151-62. PubMed: 23649518 MGI: J:208963
Dey DC; Bronson RP; Dahl J; Carroll JP; Benjamin TL. 2000. Accelerated development of polyoma tumors and embryonic lethality: different effects of p53 loss on related mouse backgrounds Cell Growth Differ 11(5):231-7. PubMed: 10845423 MGI: J:62235
Diaz-Cruz ES; Furth PA. 2010. Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. Cancer Res 70(10):3965-74. PubMed: 20466998 MGI: J:160525
Dijkgraaf GJ; Alicke B; Weinmann L; Januario T; West K; Modrusan Z; Burdick D; Goldsmith R; Robarge K; Sutherlin D; Scales SJ; Gould SE; Yauch RL; de Sauvage FJ. 2011. Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Cancer Res 71(2):435-44. PubMed: 21123452 MGI: J:168107
Dimitrova N; Chen YC; Spector DL; de Lange T. 2008. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature 456(7221):524-8. PubMed: 18931659 MGI: J:143563
Doan PL; Himburg HA; Helms K; Russell JL; Fixsen E; Quarmyne M; Harris JR; Deoliviera D; Sullivan JM; Chao NJ; Kirsch DG; Chute JP. 2013. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med 19(3):295-304. PubMed: 23377280 MGI: J:196315
Drews-Elger K; Ortells MC; Rao A; Lopez-Rodriguez C; Aramburu J. 2009. The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress. PLoS One 4(4):e5245. PubMed: 19381288 MGI: J:148271
Driskell I; Oda H; Blanco S; Nascimento E; Humphreys P; Frye M. 2012. The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. EMBO J 31(3):616-29. PubMed: 22117221 MGI: J:181779
Du W; Amarachintha S; Wilson AF; Pang Q. 2016. SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells. Stem Cells 34(4):960-71. PubMed: 26676373 MGI: J:233846
Dumble ML; Knight B; Quail EA; Yeoh GC. 2001. Hepatoblast-like cells populate the adult p53 knockout mouse liver: evidence for a hyperproliferative maturation-arrested stem cell compartment. Cell Growth Differ 12(5):223-31. PubMed: 11373269 MGI: J:69799
Dunphy KA; Blackburn AC; Yan H; O'Connell LR; Jerry DJ. 2008. Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice. Breast Cancer Res 10(3):R43. PubMed: 18471300 MGI: J:139811
Duy C; Hurtz C; Shojaee S; Cerchietti L; Geng H; Swaminathan S; Klemm L; Kweon SM; Nahar R; Braig M; Park E; Kim YM; Hofmann WK; Herzog S; Jumaa H; Koeffler HP; Yu JJ; Heisterkamp N; Graeber TG; Wu H; Ye BH; Melnick A; Muschen M. 2011. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature 473(7347):384-8. PubMed: 21593872 MGI: J:172636
Eden A; Gaudet F; Waghmare A; Jaenisch R. 2003. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300(5618):455. PubMed: 12702868 MGI: J:83880
Efeyan A; Murga M; Martinez-Pastor B; Ortega-Molina A; Soria R; Collado M; Fernandez-Capetillo O; Serrano M. 2009. Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. PLoS One 4(5):e5475. PubMed: 19421407 MGI: J:148887
Eguren M; Porlan E; Manchado E; Garcia-Higuera I; Canamero M; Farinas I; Malumbres M. 2013. The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat Commun 4:2880. PubMed: 24301385 MGI: J:206141
Eischen CM; Boyd K. 2012. Decreased Mdm2 expression inhibits tumor development and extends survival independent of Arf and dependent on p53. PLoS One 7(9):e46148. PubMed: 23029416 MGI: J:192121
Elbediwy A; Vincent-Mistiaen ZI; Spencer-Dene B; Stone RK; Boeing S; Wculek SK; Cordero J; Tan EH; Ridgway R; Brunton VG; Sahai E; Gerhardt H; Behrens A; Malanchi I; Sansom OJ; Thompson BJ. 2016. Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development 143(10):1674-87. PubMed: 26989177 MGI: J:235531
Else T; Trovato A; Kim AC; Wu Y; Ferguson DO; Kuick RD; Lucas PC; Hammer GD. 2009. Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis. Cancer Cell 15(6):465-76. PubMed: 19477426 MGI: J:149664
Embree-Ku M; Boekelheide K. 2002. FasL deficiency enhances the development of tumors in p53+/- mice. Toxicol Pathol 30(6):705-13. PubMed: 12512872 MGI: J:81060
Embree-Ku M; Boekelheide K. 2002. Absence of p53 and FasL has sexually dimorphic effects on both development and reproduction. Exp Biol Med (Maywood) 227(7):545-53. PubMed: 12094020 MGI: J:103281
Emerling BM; Hurov JB; Poulogiannis G; Tsukazawa KS; Choo-Wing R; Wulf GM; Bell EL; Shim HS; Lamia KA; Rameh LE; Bellinger G; Sasaki AT; Asara JM; Yuan X; Bullock A; Denicola GM; Song J; Brown V; Signoretti S; Cantley LC. 2013. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell 155(4):844-57. PubMed: 24209622 MGI: J:205288
Enriquez-Rios V; Dumitrache LC; Downing SM; Li Y; Brown EJ; Russell HR; McKinnon PJ. 2017. DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis. J Neurosci 37(4):893-905. PubMed: 28123024 MGI: J:239152
Erker L; Schubert R; Yakushiji H; Barlow C; Larson D; Mitchell JB; Wynshaw-Boris A. 2005. Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor. Hum Mol Genet 14(12):1699-708. PubMed: 15888486 MGI: J:101124
Erlacher M; Michalak EM; Kelly PN; Labi V; Niederegger H; Coultas L; Adams JM; Strasser A; Villunger A. 2005. BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood 106(13):4131-8. PubMed: 16118324 MGI: J:124060
Evans SC; Liang M; Amos C; Gu X; Lozano G. 2004. A novel genetic modifier of p53, mop1, results in embryonic lethality. Mamm Genome 15(6):415-23. PubMed: 15181534 MGI: J:97137
Fabris VT. 2014. From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer. Cancer Genet 207(6):233-46. PubMed: 25176624 MGI: J:214799
Fahl SP; Harris B; Coffey F; Wiest DL. 2015. Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint. J Immunol 194(1):200-9. PubMed: 25416806 MGI: J:230697
Fan H; Harrell JR; Dipp S; Saifudeen Z; El-Dahr SS. 2005. A novel pathological role of p53 in kidney development revealed by gene-environment interactions. Am J Physiol Renal Physiol 288(1):F98-107. PubMed: 15383401 MGI: J:104678
Fan H; Stefkova J; El-Dahr SS. 2006. Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway. Am J Physiol Renal Physiol 291(3):F670-82. PubMed: 16571598 MGI: J:111678
Fantauzzo KA; Soriano P. 2014. PI3K-mediated PDGFRalpha signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways. Genes Dev 28(9):1005-17. PubMed: 24788519 MGI: J:211289
Farazi PA; Glickman J; Horner J; Depinho RA. 2006. Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Res 66(9):4766-73. PubMed: 16651430 MGI: J:108914
Farazi PA; Zeisberg M; Glickman J; Zhang Y; Kalluri R; DePinho RA. 2006. Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. Cancer Res 66(13):6622-7. PubMed: 16818635 MGI: J:110575
Farmaki E; Mkrtchian S; Papazian I; Papavassiliou AG; Kiaris H. 2011. ERp29 regulates response to doxorubicin by a PERK-mediated mechanism. Biochim Biophys Acta 1813(6):1165-71. PubMed: 21419175 MGI: J:175009
Farres J; Martin-Caballero J; Martinez C; Lozano JJ; Llacuna L; Ampurdanes C; Ruiz-Herguido C; Dantzer F; Schreiber V; Villunger A; Bigas A; Yelamos J. 2013. Parp-2 is required to maintain hematopoiesis following sublethal gamma-irradiation in mice. Blood 122(1):44-54. PubMed: 23678004 MGI: J:200948
Fatt MP; Cancino GI; Miller FD; Kaplan DR. 2014. p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells. Cell Death Differ 21(10):1546-59. PubMed: 24809925 MGI: J:229844
Fazeli A; Steen RG; Dickinson SL; Bautista D; Dietrich WF; Bronson RT ; Bresalier RS ; Lander ES ; Costa J ; Weinberg RA. 1997. Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas. Proc Natl Acad Sci U S A 94(19):10199-204. PubMed: 9294187 MGI: J:42974
Fedorov LM; Papadopoulos T; Tyrsin OY; Twardzik T; Gotz R; Rapp UR. 2003. Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch. Cancer Res 63(9):2268-77. PubMed: 12727849 MGI: J:83090
Feeley KP; Adams CM; Mitra R; Eischen CM. 2017. Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells. Cancer Res 77(14):3823-3833. PubMed: 28576884 MGI: J:243188
Feith DJ; Pegg AE; Fong LY. 2013. Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. Carcinogenesis 34(3):570-6. PubMed: 23222816 MGI: J:194665
Feldhahn N; Ferretti E; Robbiani DF; Callen E; Deroubaix S; Selleri L; Nussenzweig A; Nussenzweig MC. 2012. The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. EMBO J 31(20):4045-56. PubMed: 22940690 MGI: J:190019
Feng Y; Pan TC; Pant DK; Chakrabarti KR; Alvarez JV; Ruth JR; Chodosh LA. 2014. SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. Cancer Discov 4(7):790-803. PubMed: 24786206 MGI: J:217848
Feng Z; Jin S; Zupnick A; Hoh J; de Stanchina E; Lowe S; Prives C; Levine AJ. 2006. p53 tumor suppressor protein regulates the levels of huntingtin gene expression. Oncogene 25(1):1-7. PubMed: 16278683 MGI: J:104350
Fernandez-Diaz LC; Laurent A; Girasoli S; Turco M; Longobardi E; Iotti G; Jenkins NA; Fiorenza MT; Copeland NG; Blasi F. 2010. The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells. Development 137(20):3393-403. PubMed: 20826531 MGI: J:165811
Ferrao PT; Bukczynska EP; Johnstone RW; McArthur GA. 2012. Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells. Oncogene 31(13):1661-72. PubMed: 21841818 MGI: J:186150
Ferron SR; Marques-Torrejon MA; Mira H; Flores I; Taylor K; Blasco MA; Farinas I. 2009. Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis. J Neurosci 29(46):14394-407. PubMed: 19923274 MGI: J:158281
Fiancette R; Rouaud P; Vincent-Fabert C; Laffleur B; Magnone V; Cogne M; Denizot Y. 2011. A p53 defect sensitizes various stages of B cell development to lymphomagenesis in mice carrying an IgH 3' regulatory region-driven c-myc transgene. J Immunol 187(11):5772-82. PubMed: 22039300 MGI: J:179752
Fingerle-Rowson G; Petrenko O; Metz CN; Forsthuber TG; Mitchell R; Huss R; Moll U; Muller W; Bucala R. 2003. The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A 100(16):9354-9. PubMed: 12878730 MGI: J:84791
Firat E; Tsurumi C; Gaedicke S; Huai J; Niedermann G. 2009. Tripeptidyl peptidase II plays a role in the radiation response of selected primary cell types but not based on nuclear translocation and p53 stabilization. Cancer Res 69(8):3325-31. PubMed: 19351849 MGI: J:147724
Fisher GH; Wellen SL; Klimstra D; Lenczowski JM; Tichelaar JW; Lizak MJ; Whitsett JA; Koretsky A; Varmus HE. 2001. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev 15(24):3249-62. PubMed: 11751631 MGI: J:73468
Fleischmann A; Jochum W; Eferl R; Witowsky J; Wagner EF. 2003. Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene. Cancer Cell 4(6):477-82. PubMed: 14706339 MGI: J:89283
Flores ER; Sengupta S; Miller JB; Newman JJ; Bronson R; Crowley D; Yang A; McKeon F; Jacks T. 2005. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell 7(4):363-73. PubMed: 15837625 MGI: J:98958
Flores I; Blasco MA. 2009. A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres. PLoS One 4(3):e4934. PubMed: 19295915 MGI: J:147468
Floriddia EM; Rathore KI; Tedeschi A; Quadrato G; Wuttke A; Lueckmann JM; Kigerl KA; Popovich PG; Di Giovanni S. 2012. p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury. J Neurosci 32(40):13956-70. PubMed: 23035104 MGI: J:190730
Fong LY; Ishii H; Nguyen VT; Vecchione A; Farber JL; Croce CM; Huebner K. 2003. p53 Deficiency Accelerates Induction and Progression of Esophageal and Forestomach Tumors in Zinc-deficient Mice. Cancer Res 63(1):186-95. PubMed: 12517797 MGI: J:81055
Fong LY; Jiang Y; Farber JL. 2006. Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. Carcinogenesis 27(7):1489-96. PubMed: 16543248 MGI: J:112059
Forsberg K; Wuttke A; Quadrato G; Chumakov PM; Wizenmann A; Di Giovanni S. 2013. The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling. J Neurosci 33(36):14318-30. PubMed: 24005285 MGI: J:201646
Foster SS; De S; Johnson LK; Petrini JH; Stracker TH. 2012. Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression. Proc Natl Acad Sci U S A 109(25):9953-8. PubMed: 22670056 MGI: J:185501
Franco G; Guarnotta C; Frossi B; Piccaluga PP; Boveri E; Gulino A; Fuligni F; Rigoni A; Porcasi R; Buffa S; Betto E; Florena AM; Franco V; Iannitto E; Arcaini L; Pileri SA; Pucillo C; Colombo MP; Sangaletti S; Tripodo C. 2014. Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma. Blood 123(12):1836-49. PubMed: 24452203 MGI: J:209653
Francoz S; Froment P; Bogaerts S; De Clercq S; Maetens M; Doumont G; Bellefroid E; Marine JC. 2006. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci U S A 103(9):3232-7. PubMed: 16492744 MGI: J:120591
Frappart PO; Lee Y; Lamont J; McKinnon PJ. 2007. BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26(11):2732-42. PubMed: 17476307 MGI: J:122559
Frappart PO; Lee Y; Russell HR; Chalhoub N; Wang YD; Orii KE; Zhao J; Kondo N; Baker SJ; McKinnon PJ. 2009. Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci U S A 106(6):1880-5. PubMed: 19164512 MGI: J:144617
Freie BW; Ciccone SL; Li X; Plett PA; Orschell CM; Srour EF; Hanenberg H; Schindler D; Lee SH; Clapp DW. 2004. A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint. J Biol Chem 279(49):50986-93. PubMed: 15377654 MGI: J:95193
Fuhrken PG; Apostolidis PA; Lindsey S; Miller WM; Papoutsakis ET. 2008. Tumor suppressor protein p53 regulates megakaryocytic polyploidization and apoptosis. J Biol Chem 283(23):15589-600. PubMed: 18397889 MGI: J:137554
Galvao RP; Kasina A; McNeill RS; Harbin JE; Foreman O; Verhaak RG; Nishiyama A; Miller CR; Zong H. 2014. Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process. Proc Natl Acad Sci U S A 111(40):E4214-23. PubMed: 25246577 MGI: J:216462
Gao Y; Ferguson DO; Xie W; Manis JP; Sekiguchi J; Frank KM; Chaudhuri J; Horner J; DePinho RA; Alt FW. 2000. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development Nature 404(6780):897-900. PubMed: 10786799 MGI: J:61973
Garbe AI; Vermeer B; Gamrekelashvili J; von Wasielewski R; Greten FR; Westendorf AM; Buer J; Schmid RM; Manns MP; Korangy F; Greten TF. 2006. Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses. Cancer Res 66(1):508-16. PubMed: 16397267 MGI: J:105147
Garcia D; Warr MR; Martins CP; Brown Swigart L; Passegue E; Evan GI. 2011. Validation of MdmX as a therapeutic target for reactivating p53 in tumors. Genes Dev 25(16):1746-57. PubMed: 21852537 MGI: J:174671
Garcia-Beccaria M; Martinez P; Mendez-Pertuz M; Martinez S; Blanco-Aparicio C; Canamero M; Mulero F; Ambrogio C; Flores JM; Megias D; Barbacid M; Pastor J; Blasco MA. 2015. Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage. EMBO Mol Med 7(7):930-49. PubMed: 25971796 MGI: J:233465
Garcia-Cao I; Garcia-Cao M; Martin-Caballero J; Criado LM; Klatt P; Flores JM; Weill JC; Blasco MA; Serrano M. 2002. 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J 21(22):6225-35. PubMed: 12426394 MGI: J:80311
Garrison SP; Phillips DC; Jeffers JR; Chipuk JE; Parsons MJ; Rehg JE; Opferman JT; Green DR; Zambetti GP. 2012. Genetically defining the mechanism of Puma- and Bim-induced apoptosis. Cell Death Differ 19(4):642-9. PubMed: 22015606 MGI: J:203075
Garza R; Hudson RA 3rd; McMahan CA; Walter CA; Vogel KS. 2007. A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1. Mutat Res 615(1-2):98-110. PubMed: 17208258 MGI: J:117442
Gatzka M; Tasdogan A; Hainzl A; Allies G; Maity P; Wilms C; Wlaschek M; Scharffetter-Kochanek K. 2015. Interplay of H2A deubiquitinase 2A-DUB/Mysm1 and the p19(ARF)/p53 axis in hematopoiesis, early T-cell development and tissue differentiation. Cell Death Differ 22(9):1451-62. PubMed: 25613381 MGI: J:232680
Gavino C; Richard S. 2011. Loss of p53 in quaking viable mice leads to Purkinje cell defects and reduced survival. Sci Rep 1:84. PubMed: 22355603 MGI: J:206122
Gendronneau G; Lemieux M; Morneau M; Paradis J; Tetu B; Frenette N; Aubin J; Jeannotte L. 2010. Influence of Hoxa5 on p53 tumorigenic outcome in mice. Am J Pathol 176(2):995-1005. PubMed: 20042682 MGI: J:156759
Ghebranious N; Knoll BJ; Wu H; Lozano G; Sell S. 1995. Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Mol Carcinog 13(2):104-11. PubMed: 7605578 MGI: J:27363
Giblin W; Chatterji M; Westfield G; Masud T; Theisen B; Cheng HL; DeVido J; Alt FW; Ferguson DO; Schatz DG; Sekiguchi J. 2009. Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation. Blood 113(13):2965-75. PubMed: 19126872 MGI: J:146912
Gil-Perotin S; Haines JD; Kaur J; Marin-Husstege M; Spinetta MJ; Kim KH; Duran-Moreno M; Schallert T; Zindy F; Roussel MF; Garcia-Verdugo JM; Casaccia P. 2011. Roles of p53 and p27(Kip1) in the regulation of neurogenesis in the murine adult subventricular zone. Eur J Neurosci 34(7):1040-52. PubMed: 21899604 MGI: J:178012
Gil-Perotin S; Marin-Husstege M; Li J; Soriano-Navarro M; Zindy F; Roussel MF; Garcia-Verdugo JM; Casaccia-Bonnefil P. 2006. Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors. J Neurosci 26(4):1107-16. PubMed: 16436596 MGI: J:104815
Gilad O; Nabet BY; Ragland RL; Schoppy DW; Smith KD; Durham AC; Brown EJ. 2010. Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res 70(23):9693-702. PubMed: 21098704 MGI: J:166996
Girardini JE; Napoli M; Piazza S; Rustighi A; Marotta C; Radaelli E; Capaci V; Jordan L; Quinlan P; Thompson A; Mano M; Rosato A; Crook T; Scanziani E; Means AR; Lozano G; Schneider C; Del Sal G. 2011. A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. Cancer Cell 20(1):79-91. PubMed: 21741598 MGI: J:174543
Gonzalez-Suarez E; Flores JM; Blasco MA. 2002. Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol Cell Biol 22(20):7291-301. PubMed: 12242304 MGI: J:79366
Goretsky T; Dirisina R; Sinh P; Mittal N; Managlia E; Williams DB; Posca D; Ryu H; Katzman RB; Barrett TA. 2012. p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBD. Am J Pathol 181(4):1306-15. PubMed: 22863952 MGI: J:188612
Gorrini C; Squatrito M; Luise C; Syed N; Perna D; Wark L; Martinato F; Sardella D; Verrecchia A; Bennett S; Confalonieri S; Cesaroni M; Marchesi F; Gasco M; Scanziani E; Capra M; Mai S; Nuciforo P; Crook T; Lough J; Amati B. 2007. Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature 448(7157):1063-7. PubMed: 17728759 MGI: J:125164
Gostissa M; Yan CT; Bianco JM; Cogne M; Pinaud E; Alt FW. 2009. Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region. Nature 462(7274):803-7. PubMed: 20010689 MGI: J:155801
Grabow S; Delbridge AR; Aubrey BJ; Vandenberg CJ; Strasser A. 2016. Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis. Cell Rep 14(10):2337-47. PubMed: 26947081 MGI: J:234560
Grabow S; Delbridge AR; Valente LJ; Strasser A. 2014. MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice. Blood 124(26):3939-46. PubMed: 25368374 MGI: J:220777
Grabow S; Waring P; Happo L; Cook M; Mason KD; Kelly PN; Strasser A. 2012. Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice. Cell Death Differ 19(4):623-32. PubMed: 21997189 MGI: J:203078
Gray DH; Kupresanin F; Berzins SP; Herold MJ; O'Reilly LA; Bouillet P; Strasser A. 2012. The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens. Immunity 37(3):451-62. PubMed: 22960223 MGI: J:187669
Green MR; Vicente-Duenas C; Romero-Camarero I; Long Liu C; Dai B; Gonzalez-Herrero I; Garcia-Ramirez I; Alonso-Escudero E; Iqbal J; Chan WC; Campos-Sanchez E; Orfao A; Pintado B; Flores T; Blanco O; Jimenez R; Martinez-Climent JA; Criado FJ; Cenador MB; Zhao S; Natkunam Y; Lossos IS; Majeti R; Melnick A; Cobaleda C; Alizadeh AA; Sanchez-Garcia I. 2014. Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma. Nat Commun 5:3904. PubMed: 24887457 MGI: J:221269
Gregor M; Zeold A; Oehler S; Marobela KA; Fuchs P; Weigel G; Hardie DG; Wiche G. 2006. Plectin scaffolds recruit energy-controlling AMP-activated protein kinase (AMPK) in differentiated myofibres. J Cell Sci 119(Pt 9):1864-75. PubMed: 16608880 MGI: J:108933
Grier JD; Xiong S; Elizondo-Fraire AC; Parant JM; Lozano G. 2006. Tissue-Specific Differences of p53 Inhibition by Mdm2 and Mdm4. Mol Cell Biol 26(1):192-8. PubMed: 16354690 MGI: J:104114
Grote D; Moison C; Duhamel S; Chagraoui J; Girard S; Yang J; Mayotte N; Coulombe Y; Masson JY; Brown GW; Meloche S; Sauvageau G. 2015. E4F1 is a master regulator of CHK1-mediated functions. Cell Rep 11(2):210-9. PubMed: 25843717 MGI: J:228251
Gu BW; Bessler M; Mason PJ. 2008. A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice. Proc Natl Acad Sci U S A 105(29):10173-8. PubMed: 18626023 MGI: J:138335
Gunther EJ; Moody SE; Belka GK; Hahn KT; Innocent N; Dugan KD; Cardiff RD; Chodosh LA. 2003. Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Genes Dev 17(4):488-501. PubMed: 12600942 MGI: J:81934
Guo G; Marrero L; Rodriguez P; Del Valle L; Ochoa A; Cui Y. 2013. Trp53 inactivation in the tumor microenvironment promotes tumor progression by expanding the immunosuppressive lymphoid-like stromal network. Cancer Res 73(6):1668-75. PubMed: 23319800 MGI: J:196904
Guo G; Yu M; Xiao W; Celis E; Cui Y. 2017. Local Activation of p53 in the Tumor Microenvironment Overcomes Immune Suppression and Enhances Antitumor Immunity. Cancer Res 77(9):2292-2305. PubMed: 28280037 MGI: J:242166
Gustafson WC; Meyerowitz JG; Nekritz EA; Chen J; Benes C; Charron E; Simonds EF; Seeger R; Matthay KK; Hertz NT; Eilers M; Shokat KM; Weiss WA. 2014. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell 26(3):414-27. PubMed: 25175806 MGI: J:214800
Haines BB; Ryu CJ; Chang S; Protopopov A; Luch A; Kang YH; Draganov DD; Fragoso MF; Paik SG; Hong HJ; DePinho RA; Chen J. 2006. Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. Cancer Cell 9(2):109-20. PubMed: 16473278 MGI: J:106246
Haines BB; Ryu CJ; Chen J. 2006. Recombination activating genes (RAG) in lymphoma development. Cell Cycle 5(9):913-6. PubMed: 16687916 MGI: J:115811
Hakem R; de la Pompa JL; Elia A; Potter J; Mak TW. 1997. Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Nat Genet 16(3):298-302. PubMed: 9207798 MGI: J:41254
Halberg RB; Chen X; Amos-Landgraf JM; White A; Rasmussen K; Clipson L; Pasch C; Sullivan R; Pitot HC; Dove WF. 2008. The pleiotropic phenotype of apc mutations in the mouse: allele specificity and effects of the genetic background. Genetics 180(1):601-9. PubMed: 18723878 MGI: J:139675
Haldar SM; Lu Y; Jeyaraj D; Kawanami D; Cui Y; Eapen SJ; Hao C; Li Y; Doughman YQ; Watanabe M; Shimizu K; Kuivaniemi H; Sadoshima J; Margulies KB; Cappola TP; Jain MK. 2010. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med 2(26):26ra26. PubMed: 20375365 MGI: J:167880
Hallenborg P; Fjaere E; Liaset B; Petersen RK; Murano I; Sonne SB; Falkerslev M; Winther S; Jensen BA; Ma T; Hansen JB; Cinti S; Blagoev B; Madsen L; Kristiansen K. 2016. p53 regulates expression of uncoupling protein 1 through binding and repression of PPARgamma coactivator-1alpha. Am J Physiol Endocrinol Metab 310(2):E116-28. PubMed: 26578713 MGI: J:235907
Hanada T; Weitzer S; Mair B; Bernreuther C; Wainger BJ; Ichida J; Hanada R; Orthofer M; Cronin SJ; Komnenovic V; Minis A; Sato F; Mimata H; Yoshimura A; Tamir I; Rainer J; Kofler R; Yaron A; Eggan KC; Woolf CJ; Glatzel M; Herbst R; Martinez J; Penninger JM. 2013. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature 495(7442):474-80. PubMed: 23474986 MGI: J:196364
Hanel W; Marchenko N; Xu S; Yu SX; Weng W; Moll U. 2013. Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis. Cell Death Differ 20(7):898-909. PubMed: 23538418 MGI: J:228632
Happo L; Cragg MS; Phipson B; Haga JM; Jansen ES; Herold MJ; Dewson G; Michalak EM; Vandenberg CJ; Smyth GK; Strasser A; Cory S; Scott CL. 2010. Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim. Blood 116(24):5256-67. PubMed: 20829369 MGI: J:167411
Harajly M; Zalzali H; Nawaz Z; Ghayad SE; Ghamloush F; Basma H; Zainedin S; Rabeh W; Jabbour M; Tawil A; Badro DA; Evan GI; Saab R. 2015. p53 Restoration in Induction and Maintenance of Senescence: Differential Effects in Premalignant and Malignant Tumor Cells. Mol Cell Biol 36(3):438-51. PubMed: 26598601 MGI: J:235992
Hasegawa M; Zhang Y; Niibe H; Terry NH; Meistrich ML. 1998. Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice. Radiat Res 149(3):263-70. PubMed: 9496889 MGI: J:46094
Hassan NM; Painter N; Howlett CR; Farrell AW; Di Girolamo N; Lyons JG; Halliday GM. 2014. Brm inhibits the proliferative response of keratinocytes and corneal epithelial cells to ultraviolet radiation-induced damage. PLoS One 9(9):e107931. PubMed: 25254962 MGI: J:222499
Hawes JJ; Tuskan RG; Reilly KM. 2007. Nf1 expression is dependent on strain background: implications for tumor suppressor haploinsufficiency studies. Neurogenetics 8(2):121-30. PubMed: 17216419 MGI: J:121636
Heffernan-Stroud LA; Helke KL; Jenkins RW; De Costa AM; Hannun YA; Obeid LM. 2012. Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene 31(9):1166-75. PubMed: 21765468 MGI: J:186014
Heideman MR; Wilting RH; Yanover E; Velds A; de Jong J; Kerkhoven RM; Jacobs H; Wessels LF; Dannenberg JH. 2013. Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function. Blood 121(11):2038-50. PubMed: 23327920 MGI: J:195869
Hemmesi K; Squadrito ML; Mestdagh P; Conti V; Cominelli M; Piras IS; Sergi LS; Piccinin S; Maestro R; Poliani PL; Speleman F; De Palma M; Galli R. 2015. miR-135a Inhibits Cancer Stem Cell-Driven Medulloblastoma Development by Directly Repressing Arhgef6 Expression. Stem Cells 33(5):1377-89. PubMed: 25639612 MGI: J:224019
Herdman C; Mars JC; Stefanovsky VY; Tremblay MG; Sabourin-Felix M; Lindsay H; Robinson MD; Moss T. 2017. A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription. PLoS Genet 13(7):e1006899. PubMed: 28715449 MGI: J:244454
Hernandez J; Lee PP; Davis MM; Sherman LA. 2000. The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire. J Immunol 164(2):596-602. PubMed: 10623800 MGI: J:59295
Herschkowitz JI; Simin K; Weigman VJ; Mikaelian I; Usary J; Hu Z; Rasmussen KE; Jones LP; Assefnia S; Chandrasekharan S; Backlund MG; Yin Y; Khramtsov AI; Bastein R; Quackenbush J; Glazer RI; Brown PH; Green JE; Kopelovich L; Furth PA; Palazzo JP; Olopade OI; Bernard PS; Churchill GA; Van Dyke T; Perou CM. 2007. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 8(5):R76. PubMed: 17493263 MGI: J:160877
Herschkowitz JI; Zhao W; Zhang M; Usary J; Murrow G; Edwards D; Knezevic J; Greene SB; Darr D; Troester MA; Hilsenbeck SG; Medina D; Perou CM; Rosen JM. 2012. Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A 109(8):2778-83. PubMed: 21633010 MGI: J:181821
Hill R; Song Y; Cardiff RD; Van Dyke T. 2005. Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell 123(6):1001-11. PubMed: 16360031 MGI: J:106835
Hill R; Song Y; Cardiff RD; Van Dyke T. 2005. Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model. Cancer Res 65(22):10243-54. PubMed: 16288012 MGI: J:103408
Hilliard SA; Yao X; El-Dahr SS. 2014. Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol 387(1):1-14. PubMed: 24440154 MGI: J:207609
Hirai H; Romanova L; Kellner S; Verma M; Rayner S; Asakura A; Kikyo N. 2010. Post-mitotic role of nucleostemin as a promoter of skeletal muscle cell differentiation. Biochem Biophys Res Commun 391(1):299-304. PubMed: 19914205 MGI: J:156730
Hitoshi Y; Harris BT; Liu H; Popko B; Israel MA. 2008. Spinal glioma: platelet-derived growth factor B-mediated oncogenesis in the spinal cord. Cancer Res 68(20):8507-15. PubMed: 18922925 MGI: J:140662
Ho L; Stojanovski A; Whetstone H; Wei QX; Mau E; Wunder JS; Alman B. 2009. Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. Cancer Cell 16(2):126-36. PubMed: 19647223 MGI: J:151315
Hochgrafe F; Zhang L; O'Toole SA; Browne BC; Pinese M; Porta Cubas A; Lehrbach GM; Croucher DR; Rickwood D; Boulghourjian A; Shearer R; Nair R; Swarbrick A; Faratian D; Mullen P; Harrison DJ; Biankin AV; Sutherland RL; Raftery MJ; Daly RJ. 2010. Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells. Cancer Res 70(22):9391-401. PubMed: 20861192 MGI: J:166081
Hollern DP; Andrechek ER. 2014. A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer Breast Cancer Res 16:R59. MGI: J:210803
Honore B; Vorum H; Pedersen AE; Buus S; Claesson MH. 2004. Changes in protein expression in p53 deleted spontaneous thymic lymphomas. Exp Cell Res 295(1):91-101. PubMed: 15051493 MGI: J:89352
Hoogervorst EM; Bruins W; Zwart E; van Oostrom CT; van den Aardweg GJ; Beems RB; van den Berg J; Jacks T; van Steeg H; de Vries A. 2005. Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas. Cancer Res 65(9):3610-6. PubMed: 15867355 MGI: J:98840
Hoogervorst EM; van Oostrom CT; Beems RB; van Benthem J; Gielis S; Vermeulen JP; Wester PW; Vos JG; de Vries A; van Steeg H. 2004. p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice. Cancer Res 64(15):5118-26. PubMed: 15289314 MGI: J:91875
Hopp RM; Ransom N; Hilsenbeck SG; Papermaster DS; Windle JJ. 1998. Apoptosis in the murine rd1 retinal degeneration is predominantly p53-independent. Mol Vis 4:5. PubMed: 9485488 MGI: J:47520
Hoshino A; Matoba S; Iwai-Kanai E; Nakamura H; Kimata M; Nakaoka M; Katamura M; Okawa Y; Ariyoshi M; Mita Y; Ikeda K; Ueyama T; Okigaki M; Matsubara H. 2012. p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. J Mol Cell Cardiol 52(1):175-84. PubMed: 22044588 MGI: J:183674
Houlihan SL; Feng Y. 2014. The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. Elife 3:e03297. PubMed: 25245017 MGI: J:218049
Hu W; Feng Z; Teresky AK; Levine AJ. 2007. p53 regulates maternal reproduction through LIF. Nature 450(7170):721-4. PubMed: 18046411 MGI: J:130377
Hu Y; Le Leu RK; Young GP. 2005. Absence of acute apoptotic response to genotoxic carcinogens in p53-deficient mice is associated with increased susceptibility to azoxymethane-induced colon tumours. Int J Cancer 115(4):561-7. PubMed: 15700305 MGI: J:98930
Hu Y; Le Leu RK; Young GP. 2005. Sulindac corrects defective apoptosis and suppresses azoxymethane-induced colonic oncogenesis in p53 knockout mice. Int J Cancer 116(6):870-5. PubMed: 15849741 MGI: J:100059
Hu Y; Zou Y; Hala M; Dietrich H; Wick G; Xu Q. 2000. Prolonged survival of heart allografts from p53-deficient mice. Transplantation 69(12):2634-40. PubMed: 10910287 MGI: J:63463
Huang L; Yan Z; Liao X; Li Y; Yang J; Wang ZG; Zuo Y; Kawai H; Shadfan M; Ganapathy S; Yuan ZM. 2011. The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo. Proc Natl Acad Sci U S A 108(29):12001-6. PubMed: 21730163 MGI: J:174359
Huber C; Bobek N; Kuball J; Thaler S; Hoffarth S; Huber C; Theobald M; Schuler M. 2005. Inhibitors of apoptosis confer resistance to tumour suppression by adoptively transplanted cytotoxic T-lymphocytes in vitro and in vivo. Cell Death Differ 12(4):317-25. PubMed: 15678149 MGI: J:111871
Huse JT; Holland EC. 2009. Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol 19(1):132-43. PubMed: 19076778 MGI: J:173443
Iida K; Itoh K; Maher JM; Kumagai Y; Oyasu R; Mori Y; Shimazui T; Akaza H; Yamamoto M. 2007. Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis. Carcinogenesis 28(11):2398-403. PubMed: 17602169 MGI: J:126703
Ikeda S; Hawes NL; Chang B; Avery CS; Smith RS; Nishina PM. 1999. Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice. Invest Ophthalmol Vis Sci 40(8):1874-8. PubMed: 10393064 MGI: J:55873
Inoue S; Hao Z; Elia AJ; Cescon D; Zhou L; Silvester J; Snow B; Harris IS; Sasaki M; Li WY; Itsumi M; Yamamoto K; Ueda T; Dominguez-Brauer C; Gorrini C; Chio II; Haight J; You-Ten A; McCracken S; Wakeham A; Ghazarian D; Penn LJ; Melino G; Mak TW. 2013. Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev 27(10):1101-14. PubMed: 23699408 MGI: J:199183
Inoue S; Tomasini R; Rufini A; Elia AJ; Agostini M; Amelio I; Cescon D; Dinsdale D; Zhou L; Harris IS; Lac S; Silvester J; Li WY; Sasaki M; Haight J; Brustle A; Wakeham A; McKerlie C; Jurisicova A; Melino G; Mak TW. 2014. TAp73 is required for spermatogenesis and the maintenance of male fertility. Proc Natl Acad Sci U S A 111(5):1843-8. PubMed: 24449892 MGI: J:206432
Ischenko I; Petrenko O; Hayman MJ. 2014. Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas. Proc Natl Acad Sci U S A 111(9):3466-71. PubMed: 24550494 MGI: J:207404
Itahana K; Mao H; Jin A; Itahana Y; Clegg HV; Lindstrom MS; Bhat KP; Godfrey VL; Evan GI; Zhang Y. 2007. Targeted Inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 12(4):355-66. PubMed: 17936560 MGI: J:126004
Iwakuma T; Parant JM; Fasulo M; Zwart E; Jacks T; de Vries A; Lozano G. 2004. Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice. Oncogene 23(46):7644-50. PubMed: 15361844 MGI: J:93838
Iwakuma T; Tochigi Y; Van Pelt CS; Caldwell LC; Terzian T; Parant JM; Chau GP; Koch JG; Eischen CM; Lozano G. 2008. Mtbp haploinsufficiency in mice increases tumor metastasis. Oncogene 27(13):1813-20. PubMed: 17906694 MGI: J:135509
Jabbour AM; Heraud JE; Daunt CP; Kaufmann T; Sandow J; O'Reilly LA; Callus BA; Lopez A; Strasser A; Vaux DL; Ekert PG. 2009. Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death Differ 16(4):555-63. PubMed: 19079139 MGI: J:158076
Jackson JG; Pant V; Li Q; Chang LL; Quintas-Cardama A; Garza D; Tavana O; Yang P; Manshouri T; Li Y; El-Naggar AK; Lozano G. 2012. p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell 21(6):793-806. PubMed: 22698404 MGI: J:189284
Jackson-Grusby L; Beard C; Possemato R; Tudor M; Fambrough D; Csankovszki G; Dausman J; Lee P; Wilson C; Lander E; Jaenisch R. 2001. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation Nat Genet 27(1):31-9. PubMed: 11137995 MGI: J:66733
Jacobs C; Huang Y; Masud T; Lu W; Westfield G; Giblin W; Sekiguchi JM. 2011. A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis. Hum Mol Genet 20(4):806-19. PubMed: 21147755 MGI: J:168001
Jacobs SB; Basak S; Murray JI; Pathak N; Attardi LD. 2007. Siva is an apoptosis-selective p53 target gene important for neuronal cell death. Cell Death Differ 14(7):1374-85. PubMed: 17464332 MGI: J:139268
Jaramillo-Rangel G; Ortega-Martinez M; Sepulveda-Saavedra J; Saucedo-Cardenas O; Montes-de-Oca-Luna R. 2013. p53 E3 ubiquitin protein ligase homolog regulates p53 in vivo in the adult mouse eye lens. Mol Vis 19:2468-76. PubMed: 24339722 MGI: J:211856
Jaras M; Miller PG; Chu LP; Puram RV; Fink EC; Schneider RK; Al-Shahrour F; Pena P; Breyfogle LJ; Hartwell KA; McConkey ME; Cowley GS; Root DE; Kharas MG; Mullally A; Ebert BL. 2014. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. J Exp Med 211(4):605-12. PubMed: 24616378 MGI: J:210826
Jeffers JR; Parganas E; Lee Y; Yang C; Wang J; Brennan J; MacLean KH; Han J; Chittenden T; Ihle JN; McKinnon PJ; Cleveland JL; Zambetti GP. 2003. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4(4):321-8. PubMed: 14585359 MGI: J:115660
Jenkins LM; Durell SR; Mazur SJ; Appella E. 2012. p53 N-terminal phosphorylation: a defining layer of complex regulation. Carcinogenesis 33(8):1441-9. PubMed: 22505655 MGI: J:190776
Jerome-Majewska LA; Jenkins GP; Ernstoff E; Zindy F; Sherr CJ; Papaioannou VE. 2005. Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway. Dev Dyn 234(4):922-33. PubMed: 16222716 MGI: J:102855
Jerry DJ; Kittrell FS; Kuperwasser C; Laucirica R; Dickinson ES; Bonilla PJ; Butel JS; Medina D. 2000. A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development. Oncogene 19(8):1052-8. PubMed: 10713689 MGI: J:61014
Jerry DJ; Kuperwasser C; Downing SR; Pinkas J; He C; Dickinson E; Marconi S; Naber SP. 1998. Delayed involution of the mammary epithelium in BALB/c-p53null mice. Oncogene 17(18):2305-12. PubMed: 9811461 MGI: J:50936
Jiang L; Kon N; Li T; Wang SJ; Su T; Hibshoosh H; Baer R; Gu W. 2015. Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520(7545):57-62. PubMed: 25799988 MGI: J:220466
Jiang W; Crowe JL; Liu X; Nakajima S; Wang Y; Li C; Lee BJ; Dubois RL; Liu C; Yu X; Lan L; Zha S. 2015. Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining. Mol Cell 58(1):172-85. PubMed: 25818648 MGI: J:220823
Jiang Y; Xie X; Li Z; Wang Z; Zhang Y; Ling Z; Pan Y; Wang Z; Chen Y. 2011. Functional Cooperation of RKTG with p53 in Tumorigenesis and Epithelial-Mesenchymal Transition. Cancer Res 71(8):2959-68. PubMed: 21385899 MGI: J:170994
Jiang Z; Liang P; Leng R; Guo Z; Liu Y; Liu X; Bubnic S; Keating A; Murray D; Goss P; Zacksenhaus E. 2000. E2F1 and p53 are dispensable, whereas p21(Waf1/Cip1) cooperates with Rb to restrict endoreduplication and apoptosis during skeletal myogenesis Dev Biol 227(1):28-41. PubMed: 11076674 MGI: J:65679
Jin X; Eroglu B; Cho W; Yamaguchi Y; Moskophidis D; Mivechi NF. 2012. Inactivation of heat shock factor Hsf4 induces cellular senescence and suppresses tumorigenesis in vivo. Mol Cancer Res 10(4):523-34. PubMed: 22355043 MGI: J:205392
Johannessen CM; Johnson BW; Williams SM; Chan AW; Reczek EE; Lynch RC; Rioth MJ; McClatchey A; Ryeom S; Cichowski K. 2008. TORC1 is essential for NF1-associated malignancies. Curr Biol 18(1):56-62. PubMed: 18164202 MGI: J:144615
Johnson DA; Zhang J; Frase S; Wilson M; Rodriguez-Galindo C; Dyer MA. 2007. Neuronal differentiation and synaptogenesis in retinoblastoma. Cancer Res 67(6):2701-11. PubMed: 17363591 MGI: J:120315
Johnson L; Mercer K; Greenbaum D; Bronson RT; Crowley D; Tuveson DA; Jacks T. 2001. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410(6832):1111-6. PubMed: 11323676 MGI: J:68981
Johnson NC; Dillard ME; Baluk P; McDonald DM; Harvey NL; Frase SL; Oliver G. 2008. Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev 22(23):3282-91. PubMed: 19056883 MGI: J:142041
Johnson TM; Attardi LD. 2006. Dissecting p53 tumor suppressor function in vivo through the analysis of genetically modified mice. Cell Death Differ 13(6):902-8. PubMed: 16557272 MGI: J:126413
Jonker MJ; Bruning O; van Iterson M; Schaap MM; van der Hoeven TV; Vrieling H; Beems RB; de Vries A; van Steeg H; Breit TM; Luijten M. 2009. Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models. Carcinogenesis 30(10):1805-12. PubMed: 19696161 MGI: J:153537
Joseph NM; Mosher JT; Buchstaller J; Snider P; McKeever PE; Lim M; Conway SJ; Parada LF; Zhu Y; Morrison SJ. 2008. The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell 13(2):129-40. PubMed: 18242513 MGI: J:131914
Jung H; Kim MJ; Kim DO; Kim WS; Yoon SJ; Park YJ; Yoon SR; Kim TD; Suh HW; Yun S; Min JK; Lee HG; Lee YH; Na HJ; Lee DC; Kim HC; Choi I. 2013. TXNIP Maintains the Hematopoietic Cell Pool by Switching the Function of p53 under Oxidative Stress. Cell Metab 18(1):75-85. PubMed: 23823478 MGI: J:199235
Jung KC; Park WS; Kim HJ; Choi EY; Kook MC; Lee HW; Bae Y. 2004. TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking. J Immunol 172(2):795-802. PubMed: 14707049 MGI: J:87358
Kalitsis P; Fowler KJ; Griffiths B; Earle E; Chow CW; Jamsen K; Choo KH. 2005. Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice. Genes Chromosomes Cancer 44(1):29-36. PubMed: 15898111 MGI: J:99580
Kang J; Ferguson D; Song H; Bassing C; Eckersdorff M; Alt FW; Xu Y. 2005. Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol 25(2):661-70. PubMed: 15632067 MGI: J:96007
Kappler R; Bauer R; Calzada-Wack J; Rosemann M; Hemmerlein B; Hahn H. 2004. Profiling the molecular difference between Patched- and p53-dependent rhabdomyosarcoma. Oncogene 23(54):8785-95. PubMed: 15480423 MGI: J:94710
Karlseder J; Kachatrian L; Takai H; Mercer K; Hingorani S; Jacks T; de Lange T. 2003. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol 23(18):6533-41. PubMed: 12944479 MGI: J:85440
Kawabata T; Yamaguchi S; Buske T; Luebben SW; Wallace M; Matise I; Schimenti JC; Shima N. 2011. A reduction of licensed origins reveals strain-specific replication dynamics in mice. Mamm Genome 22(9-10):506-17. PubMed: 21611832 MGI: J:177547
Kawauchi D; Robinson G; Uziel T; Gibson P; Rehg J; Gao C; Finkelstein D; Qu C; Pounds S; Ellison DW; Gilbertson RJ; Roussel MF. 2012. A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 21(2):168-80. PubMed: 22340591 MGI: J:181462
Kee BL. 2005. Id3 induces growth arrest and caspase-2-dependent apoptosis in B lymphocyte progenitors. J Immunol 175(7):4518-27. PubMed: 16177095 MGI: J:118939
Kelly GL; Grabow S; Glaser SP; Fitzsimmons L; Aubrey BJ; Okamoto T; Valente LJ; Robati M; Tai L; Fairlie WD; Lee EF; Lindstrom MS; Wiman KG; Huang DC; Bouillet P; Rowe M; Rickinson AB; Herold MJ; Strasser A. 2014. Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53. Genes Dev 28(1):58-70. PubMed: 24395247 MGI: J:205583
Kelly PN; White MJ; Goschnick MW; Fairfax KA; Tarlinton DM; Kinkel SA; Bouillet P; Adams JM; Kile BT; Strasser A. 2010. Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development. Cell Death Differ 17(10):1655-64. PubMed: 20431598 MGI: J:186358
Kerr JB; Hutt KJ; Michalak EM; Cook M; Vandenberg CJ; Liew SH; Bouillet P; Mills A; Scott CL; Findlay JK; Strasser A. 2012. DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa. Mol Cell 48(3):343-52. PubMed: 23000175 MGI: J:191005
Khandanpour C; Phelan JD; Vassen L; Schutte J; Chen R; Horman SR; Gaudreau MC; Krongold J; Zhu J; Paul WE; Duhrsen U; Gottgens B; Grimes HL; Moroy T. 2013. Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia. Cancer Cell 23(2):200-14. PubMed: 23410974 MGI: J:194309
Kiaris H; Chatzistamou I; Trimis G; Frangou-Plemmenou M; Pafiti-Kondi A; Kalofoutis A. 2005. Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis. Cancer Res 65(5):1627-30. PubMed: 15753354 MGI: J:97031
Kim KH; Back JH; Zhu Y; Arbesman J; Athar M; Kopelovich L; Kim AL; Bickers DR. 2011. Resveratrol targets transforming growth factor-beta2 signaling to block UV-induced tumor progression. J Invest Dermatol 131(1):195-202. PubMed: 20720562 MGI: J:182104
Kim TS; Lee DH; Kim SK; Shin SY; Seo EJ; Lim DS. 2012. Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation. Cancer Res 72(20):5386-95. PubMed: 22926556 MGI: J:192938
Kimata M; Matoba S; Iwai-Kanai E; Nakamura H; Hoshino A; Nakaoka M; Katamura M; Okawa Y; Mita Y; Okigaki M; Ikeda K; Tatsumi T; Matsubara H. 2010. p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress. Am J Physiol Heart Circ Physiol 299(6):H1908-16. PubMed: 20935145 MGI: J:167245
Kirsch DG; Santiago PM; di Tomaso E; Sullivan JM; Hou WS; Dayton T; Jeffords LB; Sodha P; Mercer KL; Cohen R; Takeuchi O; Korsmeyer SJ; Bronson RT; Kim CF; Haigis KM; Jain RK; Jacks T. 2010. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science 327(5965):593-6. PubMed: 20019247 MGI: J:156707
Klochendler-Yeivin A; Picarsky E; Yaniv M. 2006. Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex. Mol Cell Biol 26(7):2661-74. PubMed: 16537910 MGI: J:106934
Klusmann I; Rodewald S; Muller L; Friedrich M; Wienken M; Li Y; Schulz-Heddergott R; Dobbelstein M. 2016. p53 Activity Results in DNA Replication Fork Processivity. Cell Rep 17(7):1845-1857. PubMed: 27829155 MGI: J:242330
Knostman KA; Jhiang SM; Capen CC. 2007. Genetic alterations in thyroid cancer: the role of mouse models. Vet Pathol 44(1):1-14. PubMed: 17197619 MGI: J:129329
Knudson CM; Johnson GM; Lin Y; Korsmeyer SJ. 2001. Bax accelerates tumorigenesis in p53-deficient mice. Cancer Res 61(2):659-65. PubMed: 11212265 MGI: J:67325
Koch JG; Gu X; Han Y; El-Naggar AK; Olson MV; Medina D; Jerry DJ; Blackburn AC; Peltz G; Amos CI; Lozano G. 2007. Mammary tumor modifiers in BALB/cJ mice heterozygous for p53. Mamm Genome 18(5):300-9. PubMed: 17557176 MGI: J:123935
Kohn MJ; Bronson RT; Harlow E; Dyson NJ; Yamasaki L. 2003. Dp1 is required for extra-embryonic development. Development 130(7):1295-305. PubMed: 12588846 MGI: J:81580
Komarov PG; Komarova EA; Kondratov RV; Christov-Tselkov K; Coon JS; Chernov MV; Gudkov AV. 1999. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy [see comments] Science 285(5434):1733-7. PubMed: 10481009 MGI: J:57531
Komarova EA; Christov K; Faerman AI; Gudkov AV. 2000. Different impact of p53 and p21 on the radiation response of mouse tissues. Oncogene 19(33):3791-8. PubMed: 10949934 MGI: J:63921
Komarova EA; Kondratov RV; Wang K; Christov K; Golovkina TV; Goldblum JR; Gudkov AV. 2004. Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene 23(19):3265-71. PubMed: 15064735 MGI: J:89739
Komatsu D; Abe T; Sano Y; Shimazaki K; Tomita M; Kanayama N; Takahashi K. 2007. Increase of the trophoblast giant cells with prolactin-releasing peptide (PrRP) receptor expression in p53-null mice. Mol Reprod Dev 74(9):1089-94. PubMed: 17410546 MGI: J:125205
Kon N; Zhong J; Kobayashi Y; Li M; Szabolcs M; Ludwig T; Canoll PD; Gu W. 2011. Roles of HAUSP-mediated p53 regulation in central nervous system development. Cell Death Differ 18(8):1366-75. PubMed: 21350561 MGI: J:203102
Konishi A; de Lange T. 2008. Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes Dev 22(9):1221-30. PubMed: 18451109 MGI: J:134654
Krais AM; Speksnijder EN; Melis JP; Singh R; Caldwell A; Gamboa da Costa G; Luijten M; Phillips DH; Arlt VM. 2016. Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice. Int J Cancer 138(4):976-82. PubMed: 26335255 MGI: J:227928
Krizhanovsky V; Yon M; Dickins RA; Hearn S; Simon J; Miething C; Yee H; Zender L; Lowe SW. 2008. Senescence of activated stellate cells limits liver fibrosis. Cell 134(4):657-67. PubMed: 18724938 MGI: J:145465
Ku TK; Nguyen DC; Karaman M; Gill P; Hacia JG; Crowe DL. 2007. Loss of p53 expression correlates with metastatic phenotype and transcriptional profile in a new mouse model of head and neck cancer. Mol Cancer Res 5(4):351-62. PubMed: 17426250 MGI: J:120875
Kua HY; Liu H; Leong WF; Li L; Jia D; Ma G; Hu Y; Wang X; Chau JF; Chen YG; Mishina Y; Boast S; Yeh J; Xia L; Chen GQ; He L; Goff SP; Li B. 2012. c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression. Nat Cell Biol 14(7):727-37. PubMed: 22729085 MGI: J:190763
Kuan AP; Cohen PL. 2005. p53 is required for spontaneous autoantibody production in B6/lpr lupus mice. Eur J Immunol 35(5):1653-60. PubMed: 15789337 MGI: J:97789
Kuperwasser C; Hurlbut GD; Kittrell FS; Dickinson ES; Laucirica R; Medina D; Naber SP; Jerry DJ. 2000. Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice : A model for Li-fraumeni syndrome Am J Pathol 157(6):2151-9. PubMed: 11106587 MGI: J:66136
Kuprash DV; Qin Z; Ito D; Grivennikov SI; Abe K; Drutskaya LN; Blankenstein T; Nedospasov SA. 2008. Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice. Cancer Lett 268(1):70-5. PubMed: 18442881 MGI: J:138907
Kwon CH; Zhao D; Chen J; Alcantara S; Li Y; Burns DK; Mason RP; Lee EY; Wu H; Parada LF. 2008. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res 68(9):3286-94. PubMed: 18451155 MGI: J:134611
Kwon MC; Berns A. 2013. Mouse models for lung cancer. Mol Oncol 7(2):165-77. PubMed: 23481268 MGI: J:243761
La Perle KM; Blomme EA; Sagartz JE; Capen CC. 2002. Epididymal cribriform hyperplasia with nuclear atypia in p53 homozygous knockout mice on a mixed 129/Sv-FVB/N background. Comp Med 52(6):568-71. PubMed: 12540173 MGI: J:81553
La Perle KM; Jhiang SM; Capen CC. 2000. Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas. Am J Pathol 157(2):671-7. PubMed: 10934169 MGI: J:64644
Labi V; Erlacher M; Kiessling S; Manzl C; Frenzel A; O'Reilly L; Strasser A; Villunger A. 2008. Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. J Exp Med 205(3):641-55. PubMed: 18299399 MGI: J:133084
Lackinger D; Kaina B. 2000. Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis. Mutat Res 457(1-2):113-23. PubMed: 11106803 MGI: J:119048
Lam MY; Heaney JD; Youngren KK; Kawasoe JH; Nadeau JH. 2007. Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors. Hum Mol Genet 16(18):2233-40. PubMed: 17616517 MGI: J:143392
Lam MY; Nadeau JH. 2003. Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice. APMIS 111(1):184-90; discussion 191. PubMed: 12752260 MGI: J:82965
Lang GA; Iwakuma T; Suh YA; Liu G; Rao VA; Parant JM; Valentin-Vega YA; Terzian T; Caldwell LC; Strong LC; El-Naggar AK; Lozano G. 2004. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 119(6):861-72. PubMed: 15607981 MGI: J:95318
Lawler J; Miao WM; Duquette M; Bouck N; Bronson RT; Hynes RO. 2001. Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. Am J Pathol 159(5):1949-56. PubMed: 11696456 MGI: J:72391
Le Bouteiller M; Souilhol C; Beck-Cormier S; Stedman A; Burlen-Defranoux O; Vandormael-Pournin S; Bernex F; Cumano A; Cohen-Tannoudji M. 2013. Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells. J Exp Med 210(11):2351-69. PubMed: 24062412 MGI: J:204063
Leblond F; Poirier S; Yu C; Duquette N; Mayer G; Thorin E. 2014. The anti-hypercholesterolemic effect of low p53 expression protects vascular endothelial function in mice. PLoS One 9(3):e92394. PubMed: 24647794 MGI: J:215071
Lechel A; Satyanarayana A; Ju Z; Plentz RR; Schaetzlein S; Rudolph C; Wilkens L; Wiemann SU; Saretzki G; Malek NP; Manns MP; Buer J; Rudolph KL. 2005. The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo. EMBO Rep 6(3):275-81. PubMed: 15723042 MGI: J:105079
Lee CL; Castle KD; Moding EJ; Blum JM; Williams N; Luo L; Ma Y; Borst LB; Kim Y; Kirsch DG. 2015. Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma. Nat Commun 6:8477. PubMed: 26399548 MGI: J:227224
Lee CL; Moding EJ; Cuneo KC; Li Y; Sullivan JM; Mao L; Washington I; Jeffords LB; Rodrigues RC; Ma Y; Das S; Kontos CD; Kim Y; Rockman HA; Kirsch DG. 2012. p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice. Sci Signal 5(234):ra52. PubMed: 22827996 MGI: J:231124
Lee CL; Moding EJ; Huang X; Li Y; Woodlief LZ; Rodrigues RC; Ma Y; Kirsch DG. 2012. Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice. Dis Model Mech 5(3):397-402. PubMed: 22228755 MGI: J:180576
Lee DH; Park JO; Kim TS; Kim SK; Kim TH; Kim MC; Park GS; Kim JH; Kuninaka S; Olson EN; Saya H; Kim SY; Lee H; Lim DS. 2016. LATS-YAP/TAZ controls lineage specification by regulating TGFbeta signaling and Hnf4alpha expression during liver development. Nat Commun 7:11961. PubMed: 27358050 MGI: J:240786
Lee J; Basak JM; Demehri S; Kopan R. 2007. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development 134(15):2795-806. PubMed: 17611229 MGI: J:124114
Lee JH; Gaddameedhi S; Ozturk N; Ye R; Sancar A. 2013. DNA damage-specific control of cell death by cryptochrome in p53-mutant ras-transformed cells. Cancer Res 73(2):785-91. PubMed: 23149912 MGI: J:194107
Lee JH; Sancar A. 2011. Regulation of apoptosis by the circadian clock through NF-{kappa}B signaling. Proc Natl Acad Sci U S A 108(29):12036-41. PubMed: 21690409 MGI: J:174296
Lee JY; Nakada D; Yilmaz OH; Tothova Z; Joseph NM; Lim MS; Gilliland DG; Morrison SJ. 2010. mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell 7(5):593-605. PubMed: 21040901 MGI: J:167537
Lee KE; Bar-Sagi D. 2010. Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell 18(5):448-58. PubMed: 21075310 MGI: J:166831
Lee MK; Tong WM; Wang ZQ; Sabapathy K. 2011. Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo. Cell Death Differ 18(2):214-21. PubMed: 20671749 MGI: J:186335
Lee Y; Brown EJ; Chang S; McKinnon PJ. 2014. Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss. J Neurosci 34(23):7836-44. PubMed: 24899707 MGI: J:211631
Lee Y; Katyal S; Downing SM; Zhao J; Russell HR; McKinnon PJ. 2012. Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Nat Neurosci 15(6):819-26. PubMed: 22522401 MGI: J:191367
Lee Y; Katyal S; Li Y; El-Khamisy SF; Russell HR; Caldecott KW; McKinnon PJ. 2009. The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat Neurosci 12(8):973-80. PubMed: 19633665 MGI: J:152528
Lee Y; Kawagoe R; Sasai K; Li Y; Russell HR; Curran T; McKinnon PJ. 2007. Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene 26(44):6442-7. PubMed: 17452975 MGI: J:125534
Lee Y; McKinnon PJ. 2002. DNA Ligase IV Suppresses Medulloblastoma Formation. Cancer Res 62(22):6395-9. PubMed: 12438222 MGI: J:80298
Lee Y; Miller HL; Jensen P; Hernan R; Connelly M; Wetmore C; Zindy F; Roussel MF; Curran T; Gilbertson RJ; McKinnon PJ. 2003. A molecular fingerprint for medulloblastoma. Cancer Res 63(17):5428-37. PubMed: 14500378 MGI: J:86085
Lee Y; Miller HL; Russell HR; Boyd K; Curran T; McKinnon PJ. 2006. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res 66(14):6964-71. PubMed: 16849540 MGI: J:112118
Lee Y; Shull ER; Frappart PO; Katyal S; Enriquez-Rios V; Zhao J; Russell HR; Brown EJ; McKinnon PJ. 2012. ATR maintains select progenitors during nervous system development. EMBO J 31(5):1177-89. PubMed: 22266795 MGI: J:181920
Leech M; Xue JR; Dacumos A; Hall P; Santos L; Yang Y; Li M; Kitching AR; Morand EF. 2008. The tumour suppressor gene p53 modulates the severity of antigen-induced arthritis and the systemic immune response. Clin Exp Immunol 152(2):345-53. PubMed: 18341615 MGI: J:134465
Lescale C; Abramowski V; Bedora-Faure M; Murigneux V; Vera G; Roth DB; Revy P; de Villartay JP; Deriano L. 2016. RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair. Nat Commun 7:10529. PubMed: 26833222 MGI: J:236288
Leu JI; George DL. 2007. Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria. Genes Dev 21(23):3095-109. PubMed: 18056423 MGI: J:127809
Levitt PS; Zhu M; Cassano A; Yazinski SA; Liu H; Darfler J; Peters RM; Weiss RS. 2007. Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1. Mol Cell Biol 27(6):2189-201. PubMed: 17220276 MGI: J:118898
Lewis BC; Klimstra DS; Socci ND; Xu S; Koutcher JA; Varmus HE. 2005. The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Mol Cell Biol 25(4):1228-37. PubMed: 15684377 MGI: J:96090
Li A; Chandrakanthan V; Chami O; O'Neill C. 2007. Culture of zygotes increases p53 expression in B6 mouse embryos, which reduces embryo viability. Biol Reprod 76(3):362-7. PubMed: 17093197 MGI: J:121124
Li A; Ganeshan L; O'Neill C. 2012. The effect of Trp53 gene-dosage and parent-of-origin of inheritance on mouse gamete and embryo function in vitro. Biol Reprod 86(6):175. PubMed: 22441798 MGI: J:185824
Li B; Wang X; Rasheed N; Hu Y; Boast S; Ishii T; Nakayama K; Nakayama KI; Goff SP. 2004. Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta. Genes Dev 18(15):1824-37. PubMed: 15289456 MGI: J:119329
Li C; Finkelstein D; Sherr CJ. 2013. Arf tumor suppressor and miR-205 regulate cell adhesion and formation of extraembryonic endoderm from pluripotent stem cells. Proc Natl Acad Sci U S A 110(12):E1112-21. PubMed: 23487795 MGI: J:194241
Li CC; Chu HY; Yang CW; Chou CK; Tsai TF. 2009. Aurora-A overexpression in mouse liver causes p53-dependent premitotic arrest during liver regeneration. Mol Cancer Res 7(5):678-88. PubMed: 19435814 MGI: J:205247
Li G; Alt FW; Cheng HL; Brush JW; Goff PH; Murphy MM; Franco S; Zhang Y; Zha S. 2008. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell 31(5):631-40. PubMed: 18775323 MGI: J:138774
Li M; Fang X; Baker DJ; Guo L; Gao X; Wei Z; Han S; van Deursen JM; Zhang P. 2010. The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A 107(32):14188-93. PubMed: 20663956 MGI: J:163598
Li Q; Sambandam SA; Lu HJ; Thomson A; Kim SH; Lu H; Xin Y; Lu Q. 2011. 14-3-3sigma and p63 play opposing roles in epidermal tumorigenesis. Carcinogenesis 32(12):1782-8. PubMed: 21926108 MGI: J:178010
Li Y; Chitnis N; Nakagawa H; Kita Y; Natsugoe S; Yang Y; Li Z; Wasik M; Klein-Szanto AJ; Rustgi AK; Diehl JA. 2015. PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers. Cancer Discov 5(3):288-303. PubMed: 25582697 MGI: J:222599
Li Y; Liu J; McLaughlin N; Bachvarov D; Saifudeen Z; El-Dahr SS. 2013. Genome-wide analysis of the p53 gene regulatory network in the developing mouse kidney. Physiol Genomics 45(20):948-64. PubMed: 24003036 MGI: J:201649
Li Z; Pei XH; Yan J; Yan F; Cappell KM; Whitehurst AW; Xiong Y. 2014. CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. Mol Cell 54(5):805-19. PubMed: 24793696 MGI: J:215269
Liang L; Shao C; Deng L; Mendonca MS; Stambrook PJ; Tischfield JA. 2002. Radiation-induced genetic instability in vivo depends on p53 status. Mutat Res 502(1-2):69-80. PubMed: 11996974 MGI: J:76754
Liang M; Ayanga B; Du S; Godwin AK; Hartsock JK; Evans SC. 2008. Ovca1, a candidate gene of the genetic modifier of Tp53, Mop2, affects mouse embryonic lethality. Genes Chromosomes Cancer 47(4):315-25. PubMed: 18181179 MGI: J:135526
Liao MJ; Yin C; Barlow C; Wynshaw-Boris A; van Dyke T. 1999. Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction. Mol Cell Biol 19(4):3095-102. PubMed: 10082576 MGI: J:53932
Liao MJ; Zhang XX; Hill R; Gao J; Qumsiyeh MB; Nichols W; Van Dyke T. 1998. No requirement for V(D)J recombination in p53-deficient thymic lymphoma. Mol Cell Biol 18(6):3495-501. PubMed: 9584189 MGI: J:47667
Lightfoot DA; Hoog C. 2004. Low level chromosome instability in embryonic cells of primary aneuploid mice. Cytogenet Genome Res 107(1-2):95-8. PubMed: 15305061 MGI: J:93133
Lightfoot DA; Kouznetsova A; Mahdy E; Wilbertz J; Hoog C. 2006. The fate of mosaic aneuploid embryos during mouse development. Dev Biol 289(2):384-94. PubMed: 16337934 MGI: J:104326
Lin L; Ye Y; Zakeri Z. 2006. p53, Apaf-1, caspase-3, and -9 are dispensable for Cdk5 activation during cell death. Cell Death Differ 13(1):141-50. PubMed: 16021178 MGI: J:121028
Lin MH; Leimeister C; Gessler M; Kopan R. 2000. Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers. Development 127(11):2421-32. PubMed: 10804183 MGI: J:62217
Lindemann RK; Newbold A; Whitecross KF; Cluse LA; Frew AJ; Ellis L; Williams S; Wiegmans AP; Dear AE; Scott CL; Pellegrini M; Wei A; Richon VM; Marks PA; Lowe SW; Smyth MJ; Johnstone RW. 2007. Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proc Natl Acad Sci U S A 104(19):8071-6. PubMed: 17470784 MGI: J:121589
Lindsey JC; Kawauchi D; Schwalbe EC; Solecki DJ; Selby MP; McKinnon PJ; Olson JM; Hayden JT; Grundy RG; Ellison DW; Williamson D; Bailey S; Roussel MF; Clifford SC. 2015. Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance. Oncogene 34(36):4746-57. PubMed: 25531316 MGI: J:224247
Linggi MS; Burke TL; Williams BB; Harrington A; Kraemer R; Hempstead BL; Yoon SO; Carter BD. 2005. Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor. J Biol Chem 280(14):13801-8. PubMed: 15668238 MGI: J:98749
Liu C; Sage JC; Miller MR; Verhaak RG; Hippenmeyer S; Vogel H; Foreman O; Bronson RT; Nishiyama A; Luo L; Zong H. 2011. Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell 146(2):209-21. PubMed: 21737130 MGI: J:174616
Liu G; Parant JM; Lang G; Chau P; Chavez-Reyes A; El-Naggar AK; Multani A; Chang S; Lozano G. 2004. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet 36(1):63-68. PubMed: 14702042 MGI: J:87501
Liu XS; Chandramouly G; Rass E; Guan Y; Wang G; Hobbs RM; Rajendran A; Xie A; Shah JV; Davis AJ; Scully R; Lunardi A; Pandolfi PP. 2015. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun 6:8325. PubMed: 26446488 MGI: J:227643
Liu Y; Chen C; Xu Z; Scuoppo C; Rillahan CD; Gao J; Spitzer B; Bosbach B; Kastenhuber ER; Baslan T; Ackermann S; Cheng L; Wang Q; Niu T; Schultz N; Levine RL; Mills AA; Lowe SW. 2016. Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Nature 531(7595):471-5. PubMed: 26982726 MGI: J:232714
Liu Y; Zacksenhaus E. 2000. E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses. Oncogene 19(52):6065-73. PubMed: 11146559 MGI: J:66392
Livera G; Uzbekov R; Jarrier P; Fouchecourt S; Duquenne C; Parent AS; Marine JC; Monget P. 2016. Loss of oocytes due to conditional ablation of Murine double minute 2 (Mdm2) gene is p53-dependent and results in female sterility. FEBS Lett 590(16):2566-74. PubMed: 27364741 MGI: J:235222
Lock R; Ingraham R; Maertens O; Miller AL; Weledji N; Legius E; Konicek BM; Yan SC; Graff JR; Cichowski K. 2016. Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers. J Clin Invest 126(6):2181-90. PubMed: 27159396 MGI: J:237073
Loeb KR; Kostner H; Firpo E; Norwood T; D Tsuchiya K; Clurman BE; Roberts JM. 2005. A mouse model for cyclin E-dependent genetic instability and tumorigenesis. Cancer Cell 8(1):35-47. PubMed: 16023597 MGI: J:99695
Lombard DB; Beard C; Johnson B; Marciniak RA; Dausman J; Bronson R; Buhlmann JE; Lipman R; Curry R; Sharpe A; Jaenisch R; Guarente L. 2000. Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Mol Cell Biol 20(9):3286-91. PubMed: 10757812 MGI: J:61567
Lottersberger F; Bothmer A; Robbiani DF; Nussenzweig MC; de Lange T. 2013. Role of 53BP1 oligomerization in regulating double-strand break repair. Proc Natl Acad Sci U S A 110(6):2146-51. PubMed: 23345425 MGI: J:194338
Lowe SW; Schmitt EM; Smith SW; Osborne BA; Jacks T. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes [see comments] Nature 362(6423):847-9. PubMed: 8479522 MGI: J:16022
Lu H; Huang YY; Mehrotra S; Droz-Rosario R; Liu J; Bhaumik M; White E; Shen Z. 2011. Essential Roles of BCCIP in Mouse Embryonic Development and Structural Stability of Chromosomes. PLoS Genet 7(9):e1002291. PubMed: 21966279 MGI: J:176115
Lu L; Lejtenyi D; Osmond DG. 1999. Regulation of cell survival during B lymphopoiesis: suppressed apoptosis of pro-B cells in P53-deficient mouse bone marrow. Eur J Immunol 29(8):2484-90. PubMed: 10458762 MGI: J:115316
Lu W; van Eerde AM; Fan X; Quintero-Rivera F; Kulkarni S; Ferguson H; Kim HG; Fan Y; Xi Q; Li QG; Sanlaville D; Andrews W; Sundaresan V; Bi W; Yan J; Giltay JC; Wijmenga C; de Jong TP; Feather SA; Woolf AS; Rao Y; Lupski JR; Eccles MR; Quade BJ; Gusella JF; Morton CC; Maas RL. 2007. Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet 80(4):616-32. PubMed: 17357069 MGI: J:125214
Lu X; Yang C; Yin C; Van Dyke T; Simin K. 2011. Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression. Mol Cancer Res 9(4):430-9. PubMed: 21385880 MGI: J:205228
Lu Y; Lian H; Sharma P; Schreiber-Agus N; Russell RG; Chin L; van der Horst GT; Bregman DB. 2001. Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice. Mol Cell Biol 21(5):1810-8. PubMed: 11238917 MGI: J:67340
Lu YP; Lou YR; Peng QY; Xie JG; Conney AH. 2004. Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice. Cancer Res 64(14):5020-7. PubMed: 15256477 MGI: J:91506
Ludwig T; Chapman DL; Papaioannou VE; Efstratiadis A. 1997. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev 11(10):1226-41. PubMed: 9171368 MGI: J:40594
Ludwig T; Fisher P; Ganesan S; Efstratiadis A. 2001. Tumorigenesis in mice carrying a truncating Brca1 mutation. Genes Dev 15(10):1188-93. PubMed: 11358863 MGI: J:69187
Luijten M; Speksnijder EN; van Alphen N; Westerman A; Heisterkamp SH; van Benthem J; van Kreijl CF; Beems RB; van Steeg H. 2006. Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice. Mutat Res 596(1-2):143-50. PubMed: 16464479 MGI: J:107705
Luke JJ; Van De Wetering CI; Knudson CM. 2003. Lymphoma development in Bax transgenic mice is inhibited by Bcl-2 and associated with chromosomal instability. Cell Death Differ 10(6):740-8. PubMed: 12761582 MGI: J:84205
Lundgren K; Montes de Oca Luna R; McNeill YB; Emerick EP; Spencer B; Barfield CR; Lozano G; Rosenberg MP; Finlay CA. 1997. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev 11(6):714-25. PubMed: 9087426 MGI: J:72124
Luth S; Schrader J; Zander S; Carambia A; Buchkremer J; Huber S; Reifenberg K; Yamamura K; Schirmacher P; Lohse AW; Herkel J. 2011. Chronic Inflammatory IFN-{gamma} Signaling Suppresses Hepatocarcinogenesis in Mice by Sensitizing Hepatocytes for Apoptosis. Cancer Res 71(11):3763-71. PubMed: 21512142 MGI: J:172204
Lynch CJ; Shah ZH; Allison SJ; Ahmed SU; Ford J; Warnock LJ; Li H; Serrano M; Milner J. 2010. SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53. PLoS One 5(10):e13502. PubMed: 20975832 MGI: J:166226
Ma X; Choudhury SN; Hua X; Dai Z; Li Y. 2013. Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway. Carcinogenesis 34(6):1216-23. PubMed: 23385064 MGI: J:198324
MacPherson D; Sage J; Kim T; Ho D; McLaughlin ME; Jacks T. 2004. Cell type-specific effects of Rb deletion in the murine retina. Genes Dev 18(14):1681-94. PubMed: 15231717 MGI: J:91406
Mackenzie KJ; Carroll P; Lettice L; Tarnauskaite Z; Reddy K; Dix F; Revuelta A; Abbondati E; Rigby RE; Rabe B; Kilanowski F; Grimes G; Fluteau A; Devenney PS; Hill RE; Reijns MA; Jackson AP. 2016. Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response. EMBO J 35(8):831-44. PubMed: 26903602 MGI: J:231690
Macleod KF; Hu Y; Jacks T. 1996. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J 15(22):6178-88. PubMed: 8947040 MGI: J:37025
Madenspacher JH; Azzam KM; Gowdy KM; Malcolm KC; Nick JA; Dixon D; Aloor JJ; Draper DW; Guardiola JJ; Shatz M; Menendez D; Lowe J; Lu J; Bushel P; Li L; Merrick BA; Resnick MA; Fessler MB. 2013. p53 Integrates host defense and cell fate during bacterial pneumonia. J Exp Med 210(5):891-904. PubMed: 23630228 MGI: J:198948
Maeda K; Hata R; Gillardon F; Hossmann KA. 2001. Aggravation of brain injury after transient focal ischemia in p53-deficient mice. Brain Res Mol Brain Res 88(1-2):54-61. PubMed: 11295231 MGI: J:109338
Magee JA; Ikenoue T; Nakada D; Lee JY; Guan KL; Morrison SJ. 2012. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell 11(3):415-28. PubMed: 22958933 MGI: J:191342
Malone CF; Fromm JA; Maertens O; DeRaedt T; Ingraham R; Cichowski K. 2014. Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers. Cancer Discov 4(9):1062-73. PubMed: 24913553 MGI: J:217840
Mann-Chandler MN; Kashyap M; Wright HV; Norozian F; Barnstein BO; Gingras S; Parganas E; Ryan JJ. 2005. IFN-gamma induces apoptosis in developing mast cells. J Immunol 175(5):3000-5. PubMed: 16116187 MGI: J:113205
Mantel CR; O'Leary HA; Chitteti BR; Huang X; Cooper S; Hangoc G; Brustovetsky N; Srour EF; Lee MR; Messina-Graham S; Haas DM; Falah N; Kapur R; Pelus LM; Bardeesy N; Fitamant J; Ivan M; Kim KS; Broxmeyer HE. 2015. Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock. Cell 161(7):1553-65. PubMed: 26073944 MGI: J:223364
Manzl C; Krumschnabel G; Bock F; Sohm B; Labi V; Baumgartner F; Logette E; Tschopp J; Villunger A. 2009. Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol 185(2):291-303. PubMed: 19364921 MGI: J:148929
Manzl C; Peintner L; Krumschnabel G; Bock F; Labi V; Drach M; Newbold A; Johnstone R; Villunger A. 2012. PIDDosome-independent tumor suppression by Caspase-2. Cell Death Differ 19(10):1722-32. PubMed: 22595758 MGI: J:205475
Mao JH; Wu D; DelRosario R; Castellanos A; Balmain A; Perez-Losada J. 2008. Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background. Oncogene 27(51):6596-600. PubMed: 18679420 MGI: J:142974
Mao JH; Wu D; Perez-Losada J; Nagase H; DelRosario R; Balmain A. 2003. Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene 22(52):8379-85. PubMed: 14627978 MGI: J:86813
Maor-Nof M; Romi E; Sar Shalom H; Ulisse V; Raanan C; Nof A; Leshkowitz D; Lang R; Yaron A. 2016. Axonal Degeneration Is Regulated by a Transcriptional Program that Coordinates Expression of Pro- and Anti-degenerative Factors. Neuron 92(5):991-1006. PubMed: 27889097 MGI: J:253227
Marcet-Ortega M; Pacheco S; Martinez-Marchal A; Castillo H; Flores E; Jasin M; Keeney S; Roig I. 2017. p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes. PLoS Genet 13(6):e1006845. PubMed: 28617799 MGI: J:244520
Marchlik E; Kalman R; Rosenberg N. 2005. Decreased virus population diversity in p53-null mice infected with weakly oncogenic Abelson virus. J Virol 79(18):11618-26. PubMed: 16140739 MGI: J:101770
Marino G; Ugalde AP; Salvador-Montoliu N; Varela I; Quiros PM; Cadinanos J; van der Pluijm I; Freije JM; Lopez-Otin C. 2008. Premature aging in mice activates a systemic metabolic response involving autophagy induction. Hum Mol Genet 17(14):2196-211. PubMed: 18443001 MGI: J:136907
Marjanovic M; Sanchez-Huertas C; Terre B; Gomez R; Scheel JF; Pacheco S; Knobel PA; Martinez-Marchal A; Aivio S; Palenzuela L; Wolfrum U; McKinnon PJ; Suja JA; Roig I; Costanzo V; Luders J; Stracker TH. 2015. CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination. Nat Commun 6:7676. PubMed: 26158450 MGI: J:224364
Maroulakou IG; Shibata MA; Jorcyk CL; Chen XX; Green JE. 1997. Reduced p53 dosage associated with mammary tumor metastases in C3(1)/TAG transgenic mice. Mol Carcinog 20(2):168-74. PubMed: 9364206 MGI: J:72307
Marquez-Lona EM; Tan Z; Schreiber SS. 2012. Nucleolar stress characterized by downregulation of nucleophosmin: A novel cause of neuronal degeneration. Biochem Biophys Res Commun 417(1):514-20. PubMed: 22166220 MGI: J:180301
Marsella JM; Liu BL; Vaslet CA; Kane AB. 1997. Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers. Environ Health Perspect 105 Suppl 5:1069-72. PubMed: 9400702 MGI: J:44660
Martin LJ; Chen K; Liu Z. 2005. Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. J Neurosci 25(27):6449-59. PubMed: 16000635 MGI: J:99428
Martin LJ; Kaiser A; Yu JW; Natale JE; Al-Abdulla NA. 2001. Injury-induced apoptosis of neurons in adult brain is mediated by p53-dependent and p53-independent pathways and requires Bax. J Comp Neurol 433(3):299-311. PubMed: 11298357 MGI: J:121197
Martinez P; Thanasoula M; Munoz P; Liao C; Tejera A; McNees C; Flores JM; Fernandez-Capetillo O; Tarsounas M; Blasco MA. 2009. Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev 23(17):2060-75. PubMed: 19679647 MGI: J:152077
Maser RS; Choudhury B; Campbell PJ; Feng B; Wong KK; Protopopov A; O'Neil J; Gutierrez A; Ivanova E; Perna I; Lin E; Mani V; Jiang S; McNamara K; Zaghlul S; Edkins S; Stevens C; Brennan C; Martin ES; Wiedemeyer R; Kabbarah O; Nogueira C; Histen G; Aster J; Mansour M; Duke V; Foroni L; Fielding AK; Goldstone AH; Rowe JM; Wang YA; Look AT; Stratton MR; Chin L; Futreal PA; DePinho RA. 2007. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447(7147):966-71. PubMed: 17515920 MGI: J:122751
Matheu A; Klatt P; Serrano M. 2005. Regulation of the INK4a/ARF locus by histone deacetylase inhibitors. J Biol Chem 280(51):42433-41. PubMed: 16251190 MGI: J:106797
Mathieu C; Sii-Felice K; Fouchet P; Etienne O; Haton C; Mabondzo A; Boussin FD; Mouthon MA. 2008. Endothelial cell-derived bone mo rphogenetic proteins control proliferation of neural stem/progenitor cells. Mol Cell Neurosci 38(4):569-77. PubMed: 18583149 MGI: J:141753
Matoba S; Kang JG; Patino WD; Wragg A; Boehm M; Gavrilova O; Hurley PJ; Bunz F; Hwang PM. 2006. p53 regulates mitochondrial respiration. Science 312(5780):1650-3. PubMed: 16728594 MGI: J:109676
McAllister KA; Houle CD; Malphurs J; Ward T; Collins NK; Gersch W; Wharey L; Seely JC; Betz L; Bennett LM; Wiseman RW; Davis BJ. 2006. Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation. Toxicol Pathol 34(2):187-98. PubMed: 16546942 MGI: J:109193
McAnulty PA; Skydsgaard M. 2005. Diethylstilbestrol (DES): carcinogenic potential in Xpa-/-, Xpa-/- / p53+/-, and wild-type mice during 9 months' dietary exposure. Toxicol Pathol 33(5):609-20. PubMed: 16178126 MGI: J:101774
McCarthy EE; Celebi JT; Baer R; Ludwig T. 2003. Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. Mol Cell Biol 23(14):5056-63. PubMed: 12832489 MGI: J:84329
McClatchey AI; Saotome I; Mercer K; Crowley D; Gusella JF; Bronson RT; Jacks T. 1998. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev 12(8):1121-33. PubMed: 9553042 MGI: J:47282
McConnell AM; Yao C; Yeckes AR; Wang Y; Selvaggio AS; Tang J; Kirsch DG; Stripp BR. 2016. p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway. Cell Rep 17(9):2173-2182. PubMed: 27880895 MGI: J:241243
McConnell MJ; Kaushal D; Yang AH; Kingsbury MA; Rehen SK; Treuner K; Helton R; Annas EG; Chun J; Barlow C. 2004. Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex. J Neurosci 24(37):8090-6. PubMed: 15371510 MGI: J:109775
McCormack SJ; Weaver Z; Deming S; Natarajan G; Torri J; Johnson MD; Liyanage M; Ried T; Dickson RB. 1998. Myc/p53 interactions in transgenic mouse mammary development, tumorigenesis and chromosomal instability. Oncogene 16(21):2755-66. PubMed: 9652742 MGI: J:48037
McDonnell TJ; Montes de Oca Luna R; Cho S; Amelse LL; Chavez-Reyes A; Lozano G. 1999. Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice. J Pathol 188(3):322-8. PubMed: 10419603 MGI: J:56319
McGlynn KA; Hunter K; LeVoyer T; Roush J; Wise P; Michielli RA; Shen FM; Evans AA; London WT; Buetow KH. 2003. Susceptibility to aflatoxin B1-related primary hepatocellular carcinoma in mice and humans. Cancer Res 63(15):4594-601. PubMed: 12907637 MGI: J:85696
McGowan KA; Li JZ; Park CY; Beaudry V; Tabor HK; Sabnis AJ; Zhang W; Fuchs H; de Angelis MH; Myers RM; Attardi LD; Barsh GS. 2008. Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet 40(8):963-70. PubMed: 18641651 MGI: J:139244
McGowan KA; Pang WW; Bhardwaj R; Perez MG; Pluvinage JV; Glader BE; Malek R; Mendrysa SM; Weissman IL; Park CY; Barsh GS. 2011. Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome. Blood 118(13):3622-33. PubMed: 21788341 MGI: J:177077
McKeller RN; Fowler JL; Cunningham JJ; Warner N; Smeyne RJ; Zindy F; Skapek SX. 2002. The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development. Proc Natl Acad Sci U S A 99(6):3848-53. PubMed: 11891301 MGI: J:75215
McLaughlin SK; Olsen SN; Dake B; De Raedt T; Lim E; Bronson RT; Beroukhim R; Polyak K; Brown M; Kuperwasser C; Cichowski K. 2013. The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer Cell 24(3):365-78. PubMed: 24029233 MGI: J:202603
Mebratu YA; Dickey BF; Evans C; Tesfaigzi Y. 2008. The BH3-only protein Bik/Blk/Nbk inhibits nuclear translocation of activated ERK1/2 to mediate IFNgamma-induced cell death. J Cell Biol 183(3):429-39. PubMed: 18981230 MGI: J:141068
Medina D; Kittrell FS; Hill J; Shepard A; Thordarson G; Brown P. 2005. Tamoxifen inhibition of estrogen receptor-alpha-negative mouse mammary tumorigenesis. Cancer Res 65(8):3493-6. PubMed: 15833886 MGI: J:97831
Meira LB; Cheo DL; Hammer RE; Burns DK; Reis A; Friedberg EC. 1997. Genetic interaction between HAP1/REF-1 and p53 [letter] Nat Genet 17(2):145. PubMed: 9326930 MGI: J:43195
Melis JP; Hoogervorst EM; van Oostrom CT; Zwart E; Breit TM; Pennings JL; de Vries A; van Steeg H. 2011. Genotoxic exposure: novel cause of selection for a functional DeltaN-p53 isoform. Oncogene 30(15):1764-72. PubMed: 21151170 MGI: J:170769
Melis JP; Speksnijder EN; Kuiper RV; Salvatori DC; Schaap MM; Maas S; Robinson J; Verhoef A; van Benthem J; Luijten M; van Steeg H. 2013. Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice. Toxicol Appl Pharmacol 266(2):289-97. PubMed: 23153559 MGI: J:193203
Mello SS; Valente LJ; Raj N; Seoane JA; Flowers BM; McClendon J; Bieging-Rolett KT; Lee J; Ivanochko D; Kozak MM; Chang DT; Longacre TA; Koong AC; Arrowsmith CH; Kim SK; Vogel H; Wood LD; Hruban RH; Curtis C; Attardi LD. 2017. A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. Cancer Cell 32(4):460-473.e6. PubMed: 29017057 MGI: J:243744
Mendrysa SM; McElwee MK; Michalowski J; O'Leary KA; Young KM; Perry ME. 2003. mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation. Mol Cell Biol 23(2):462-72. PubMed: 12509446 MGI: J:81065
Meng L; Lin T; Peng G; Hsu JK; Lee S; Lin SY; Tsai RY. 2013. Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells. Proc Natl Acad Sci U S A 110(28):11415-20. PubMed: 23798389 MGI: J:198698
Mercer J; Figg N; Stoneman V; Braganza D; Bennett MR. 2005. Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice. Circ Res 96(6):667-74. PubMed: 15746445 MGI: J:107632
Methot SP; Litzler LC; Trajtenberg F; Zahn A; Robert F; Pelletier J; Buschiazzo A; Magor BG; Di Noia JM. 2015. Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm. J Exp Med 212(4):581-96. PubMed: 25824822 MGI: J:222571
Michalak EM; Jansen ES; Happo L; Cragg MS; Tai L; Smyth GK; Strasser A; Adams JM; Scott CL. 2009. Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. Cell Death Differ 16(5):684-96. PubMed: 19148184 MGI: J:164197
Michalak EM; Villunger A; Adams JM; Strasser A. 2008. In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Cell Death Differ 15(6):1019-29. PubMed: 18259198 MGI: J:149036
Migliorini D; Denchi EL; Danovi D; Jochemsen A; Capillo M; Gobbi A; Helin K; Pelicci PG; Marine JC. 2002. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol 22(15):5527-38. PubMed: 12101245 MGI: J:77907
Miki T; Matsumoto T; Zhao Z; Lee CC. 2013. p53 regulates Period2 expression and the circadian clock. Nat Commun 4:2444. PubMed: 24051492 MGI: J:217260
Min JN; Huang L; Zimonjic DB; Moskophidis D; Mivechi NF. 2007. Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors. Oncogene 26(35):5086-97. PubMed: 17310987 MGI: J:125542
Min JN; Tian Y; Xiao Y; Wu L; Li L; Chang S. 2013. The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Cell Res 23(12):1396-413. PubMed: 23979016 MGI: J:221224
Minamino T; Orimo M; Shimizu I; Kunieda T; Yokoyama M; Ito T; Nojima A; Nabetani A; Oike Y; Matsubara H; Ishikawa F; Komuro I. 2009. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 15(9):1082-7. PubMed: 19718037 MGI: J:154323
Mitchel RE; Jackson JS; Carlisle SM. 2004. Upper Dose Thresholds for Radiation-Induced Adaptive Response against Cancer in High-Dose-Exposed, Cancer-Prone, Radiation-Sensitive Trp53 Heterozygous Mice. Radiat Res 162(1):20-30. PubMed: 15222780 MGI: J:91630
Mitchel RE; Jackson JS; Morrison DP; Carlisle SM. 2003. Low doses of radiation increase the latency of spontaneous lymphomas and spinal osteosarcomas in cancer-prone, radiation-sensitive Trp53 heterozygous mice. Radiat Res 159(3):320-7. PubMed: 12600234 MGI: J:81935
Mizuno S; Bogaard HJ; Kraskauskas D; Alhussaini A; Gomez-Arroyo J; Voelkel NF; Ishizaki T. 2011. p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice. Am J Physiol Lung Cell Mol Physiol 300(5):L753-61. PubMed: 21335523 MGI: J:174253
Montes de Oca Luna R; Wagner DS; Lozano G. 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378(6553):203-6. PubMed: 7477326 MGI: J:29810
Morales JC; Franco S; Murphy MM; Bassing CH; Mills KD; Adams MM; Walsh NC; Manis JP; Rassidakis GZ; Alt FW; Carpenter PB. 2006. 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proc Natl Acad Sci U S A 103(9):3310-5. PubMed: 16492765 MGI: J:107173
Morfouace M; Cheepala S; Jackson S; Fukuda Y; Patel YT; Fatima S; Kawauchi D; Shelat AA; Stewart CF; Sorrentino BP; Schuetz JD; Roussel MF. 2015. ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy. Cancer Res 75(18):3879-89. PubMed: 26199091 MGI: J:225582
Morfouace M; Shelat A; Jacus M; Freeman BB 3rd; Turner D; Robinson S; Zindy F; Wang YD; Finkelstein D; Ayrault O; Bihannic L; Puget S; Li XN; Olson JM; Robinson GW; Guy RK; Stewart CF; Gajjar A; Roussel MF. 2014. Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma. Cancer Cell 25(4):516-29. PubMed: 24684846 MGI: J:210811
Morgenbesser SD; Williams BO; Jacks T; DePinho RA. 1994. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens [see comments] Nature 371(6492):72-4. PubMed: 8072529 MGI: J:19995
Moubarak RS; Yuste VJ; Artus C; Bouharrour A; Greer PA; Menissier-de Murcia J; Susin SA. 2007. Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol 27(13):4844-62. PubMed: 17470554 MGI: J:122803
Moumen A; Patane S; Porras A; Dono R; Maina F. 2007. Met acts on Mdm2 via mTOR to signal cell survival during development. Development 134(7):1443-51. PubMed: 17329361 MGI: J:135060
Mukherjee M; Ge G; Zhang N; Huang E; Nakamura LV; Minor M; Fofanov V; Rao PH; Herron A; Pati D. 2011. Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice. PLoS One 6(7):e22167. PubMed: 21799785 MGI: J:174926
Mukhopadhyay S; Antalis TM; Nguyen KP; Hoofnagle MH; Sarkar R. 2017. Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice. Blood 129(24):3245-3255. PubMed: 28320710 MGI: J:242854
Munne PM; Gu Y; Tumiati M; Gao P; Koopal S; Uusivirta S; Sawicki J; Wei GH; Kuznetsov SG. 2014. TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli. Sci Rep 4:4663. PubMed: 24722541 MGI: J:210515
Munoz-Espin D; Canamero M; Maraver A; Gomez-Lopez G; Contreras J; Murillo-Cuesta S; Rodriguez-Baeza A; Varela-Nieto I; Ruberte J; Collado M; Serrano M. 2013. Programmed cell senescence during mammalian embryonic development. Cell 155(5):1104-18. PubMed: 24238962 MGI: J:205283
Munoz-Fontela C; Pazos M; Delgado I; Murk W; Mungamuri SK; Lee SW; Garcia-Sastre A; Moran TM; Aaronson SA. 2011. p53 serves as a host antiviral factor that enhances innate and adaptive immune responses to influenza A virus. J Immunol 187(12):6428-36. PubMed: 22105999 MGI: J:180454
Murga M; Bunting S; Montana MF; Soria R; Mulero F; Canamero M; Lee Y; McKinnon PJ; Nussenzweig A; Fernandez-Capetillo O. 2009. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet 41(8):891-8. PubMed: 19620979 MGI: J:151542
Muzumdar MD; Dorans KJ; Chung KM; Robbins R; Tammela T; Gocheva V; Li CM; Jacks T. 2016. Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers. Nat Commun 7:12685. PubMed: 27585860 MGI: J:241899
Nacht M; Jacks T. 1998. V(D)J recombination is not required for the development of lymphoma in p53-deficient mice. Cell Growth Differ 9(2):131-8. PubMed: 9486849 MGI: J:45810
Nacht M; Strasser A; Chan YR; Harris AW; Schlissel M; Bronson RT; Jacks T. 1996. Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev 10(16):2055-66. PubMed: 8769648 MGI: J:35055
Nahari D; McDaniel LD; Task LB; Daniel RL; Velasco-Miguel S; Friedberg EC. 2004. Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process. DNA Repair (Amst) 3(4):379-86. PubMed: 15010313 MGI: J:88558
Naik E; Michalak EM; Villunger A; Adams JM; Strasser A. 2007. Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa. J Cell Biol 176(4):415-24. PubMed: 17283183 MGI: J:119726
Nam SY; Lee MK; Sabapathy K. 2008. The tumour-suppressor p53 is not required for pancreatic beta cell death during diabetes and upon irradiation. J Physiol 586(2):407-17. PubMed: 18006584 MGI: J:176412
Nan X; Hou J; Maclean A; Nasir J; Lafuente MJ; Shu X; Kriaucionis S; Bird A. 2007. Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc Natl Acad Sci U S A 104(8):2709-14. PubMed: 17296936 MGI: J:125897
Nanni P; Nicoletti G; De Giovanni C; Croci S; Astolfi A; Landuzzi L; Di Carlo E; Iezzi M; Musiani P; Lollini PL. 2003. Development of Rhabdomyosarcoma in HER-2/neu Transgenic p53 Mutant Mice. Cancer Res 63(11):2728-32. PubMed: 12782574 MGI: J:83606
Napoli M; Venkatanarayan A; Raulji P; Meyers BA; Norton W; Mangala LS; Sood AK; Rodriguez-Aguayo C; Lopez-Berestein G; Vin H; Duvic M; Tetzlaff MB; Curry JL; Rook AH; Abbas HA; Coarfa C; Gunaratne PH; Tsai KY; Flores ER. 2016. DeltaNp63/DGCR8-Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer. Cancer Cell 29(6):874-88. PubMed: 27300436 MGI: J:232328
Nashed B; Yeganeh B; HayGlass KT; Moghadasian MH. 2005. Antiatherogenic effects of dietary plant sterols are associated with inhibition of proinflammatory cytokine production in Apo E-KO mice. J Nutr 135(10):2438-44. PubMed: 16177209 MGI: J:106647
Natarajan S; Li Y; Miller EE; Shih DJ; Taylor MD; Stearns TM; Bronson RT; Ackerman SL; Yoon JK; Yun K. 2013. Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma. Cancer Res 73(17):5381-90. PubMed: 23852537 MGI: J:201833
Neault M; Mallette FA; Vogel G; Michaud-Levesque J; Richard S. 2012. Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res 40(19):9513-21. PubMed: 22904064 MGI: J:199753
Nemajerova A; Mena P; Fingerle-Rowson G; Moll UM; Petrenko O. 2007. Impaired DNA damage checkpoint response in MIF-deficient mice. EMBO J 26(4):987-97. PubMed: 17290223 MGI: J:120099
Nemajerova A; Palacios G; Nowak NJ; Matsui S; Petrenko O. 2009. Targeted deletion of p73 in mice reveals its role in T cell development and lymphomagenesis. PLoS One 4(11):e7784. PubMed: 19907659 MGI: J:155422
Nemajerova A; Petrenko O; Trumper L; Palacios G; Moll UM. 2010. Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice. J Clin Invest 120(6):2070-80. PubMed: 20484818 MGI: J:161636
Nemoto S; Fergusson MM; Finkel T. 2004. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306(5704):2105-8. PubMed: 15604409 MGI: J:94823
Newton K; Strasser A. 2000. Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapy. J Exp Med 191(1):195-200. PubMed: 10620618 MGI: J:59250
Ng JM; Martinez D; Marsh ED; Zhang Z; Rappaport E; Santi M; Curran T. 2015. Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53. Cancer Res 75(21):4629-39. PubMed: 26363008 MGI: J:226786
Niederreither K; Harbers M; Chambon P; Dolle P. 1998. Expression of T:G mismatch-specific thymidine-DNA glycosylase and DNA methyl transferase genes during development and tumorigenesis. Oncogene 17(12):1577-85. PubMed: 9794235 MGI: J:50138
Niimi N; Sugo N; Aratani Y; Koyama H. 2005. Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis. Cell Death Differ 12(2):184-91. PubMed: 15647757 MGI: J:106364
Nithipongvanitch R; Ittarat W; Velez JM; Zhao R; St Clair DK; Oberley TD. 2007. Evidence for p53 as guardian of the cardiomyocyte mitochondrial genome following acute adriamycin treatment. J Histochem Cytochem 55(6):629-39. PubMed: 17312011 MGI: J:123103
Noguchi KK; Cabrera OH; Swiney BS; Salinas-Contreras P; Smith JK; Farber NB. 2015. Hedgehog regulates cerebellar progenitor cell and medulloblastoma apoptosis. Neurobiol Dis 83:35-43. PubMed: 26319366 MGI: J:227665
Nolan E; Vaillant F; Branstetter D; Pal B; Giner G; Whitehead L; Lok SW; Mann GB; Rohrbach K; Huang LY; Soriano R; Smyth GK; Dougall WC; Visvader JE; Lindeman GJ. 2016. RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers. Nat Med 22(8):933-9. PubMed: 27322743 MGI: J:239966
O'Connor L; Harris AW; Strasser A. 2000. CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types. Cancer Res 60(5):1217-20. PubMed: 10728678 MGI: J:61129
O'Hagan R; Chang S; Maser R; Mohan R; Artandi S; Chin L; DePinho R. 2002. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2(2):149-55. PubMed: 12204535 MGI: J:78479
Oakes SR; Robertson FG; Kench JG; Gardiner-Garden M; Wand MP; Green JE; Ormandy CJ. 2007. Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions. Oncogene 26(4):543-53. PubMed: 16862169 MGI: J:117839
Oberdoerffer P; Michan S; McVay M; Mostoslavsky R; Vann J; Park SK; Hartlerode A; Stegmuller J; Hafner A; Loerch P; Wright SM; Mills KD; Bonni A; Yankner BA; Scully R; Prolla TA; Alt FW; Sinclair DA. 2008. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135(5):907-18. PubMed: 19041753 MGI: J:149865
Odvody J; Vincent T; Arrate MP; Grieb B; Wang S; Garriga J; Lozano G; Iwakuma T; Haines DS; Eischen CM. 2010. A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis. Oncogene 29(22):3287-96. PubMed: 20305689 MGI: J:162036
Oghamian S; Sodir NM; Bashir MU; Shen H; Cullins AE; Carroll CA; Kundu P; Shibata D; Laird PW. 2011. Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice. Carcinogenesis 32(6):829-35. PubMed: 21362628 MGI: J:172257
Ogi H; Sakuraba Y; Kitagawa R; Xiao L; Shen C; Cynthia MA; Ohta S; Arnold MA; Ramirez N; Houghton PJ; Kitagawa K. 2015. The oncogenic role of the cochaperone Sgt1. Oncogenesis 4:e149. PubMed: 25985210 MGI: J:226313
Ohyama K; Chung CH; Chen E; Gibson CW; Misof K; Fratzl P; Shapiro IM. 1997. p53 influences mice skeletal development. J Craniofac Genet Dev Biol 17(4):161-71. PubMed: 9493073 MGI: J:113184
Olive KP; Tuveson DA; Ruhe ZC; Yin B; Willis NA; Bronson RT; Crowley D; Jacks T. 2004. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119(6):847-60. PubMed: 15607980 MGI: J:95316
Olson MV; Johnson DG; Jiang H; Xu J; Alonso MM; Aldape KD; Fuller GN; Bekele BN; Yung WK; Gomez-Manzano C; Fueyo J. 2007. Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors. Cancer Res 67(9):4005-9. PubMed: 17483310 MGI: J:121307
Onoyama I; Tsunematsu R; Matsumoto A; Kimura T; de Alboran IM; Nakayama K; Nakayama KI. 2007. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med 204(12):2875-88. PubMed: 17984302 MGI: J:128523
Opavsky R; Wang SH; Trikha P; Raval A; Huang Y; Wu YZ; Rodriguez B; Keller B; Liyanarachchi S; Wei G; Davuluri RV; Weinstein M; Felsher D; Ostrowski M; Leone G; Plass C. 2007. CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. PLoS Genet 3(9):1757-69. PubMed: 17907813 MGI: J:130029
Opitz OG; Harada H; Suliman Y; Rhoades B; Sharpless NE; Kent R; Kopelovich L; Nakagawa H; Rustgi AK. 2002. A mouse model of human oral-esophageal cancer. J Clin Invest 110(6):761-9. PubMed: 12235107 MGI: J:79110
Origanti S; Cai SR; Munir AZ; White LS; Piwnica-Worms H. 2013. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene 32(5):577-88. PubMed: 22430210 MGI: J:193369
Orii KE; Lee Y; Kondo N; McKinnon PJ. 2006. Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A 103(26):10017-22. PubMed: 16777961 MGI: J:111068
Orsulic S; Li Y; Soslow RA; Vitale-Cross LA; Gutkind JS; Varmus HE. 2002. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell 1(1):53-62. PubMed: 12086888 MGI: J:75724
Ozturk N ; Lee JH ; Gaddameedhi S ; Sancar A. 2009. Loss of cryptochrome reduces cancer risk in p53 mutant mice. Proc Natl Acad Sci U S A 106(8):2841-6. PubMed: 19188586 MGI: J:146641
Padmakumar VC; Aleem E; Berthet C; Hilton MB; Kaldis P. 2009. Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53. Mol Cell Biol 29(10):2582-93. PubMed: 19307310 MGI: J:149151
Palmero I; Murga M; Zubiaga A; Serrano M. 2002. Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2. Oncogene 21(19):2939-47. PubMed: 12082524 MGI: J:126187
Pan H; Yin C; Dyson NJ; Harlow E; Yamasaki L; Van Dyke T. 1998. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol Cell 2(3):283-92. PubMed: 9774967 MGI: J:50084
Panattoni M; Sanvito F; Basso V; Doglioni C; Casorati G; Montini E; Bender JR; Mondino A; Pardi R. 2008. Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development. J Exp Med 205(2):465-77. PubMed: 18268034 MGI: J:132114
Pani L; Horal M; Loeken MR. 2002. Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis. Genes Dev 16(6):676-80. PubMed: 11914272 MGI: J:75569
Panic L; Tamarut S; Sticker-Jantscheff M; Barkic M; Solter D; Uzelac M; Grabusic K; Volarevic S. 2006. Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol 26(23):8880-91. PubMed: 17000767 MGI: J:117590
Pant V; Xiong S; Chau G; Tsai K; Shetty G; Lozano G. 2016. Distinct downstream targets manifest p53-dependent pathologies in mice. Oncogene 35(44):5713-5721. PubMed: 27065327 MGI: J:237931
Pant V; Xiong S; Jackson JG; Post SM; Abbas HA; Quintas-Cardama A; Hamir AN; Lozano G. 2013. The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity. Genes Dev 27(17):1857-67. PubMed: 23973961 MGI: J:201057
Pantoja C; de Los Rios L; Matheu A; Antequera F; Serrano M. 2005. Inactivation of imprinted genes induced by cellular stress and tumorigenesis. Cancer Res 65(1):26-33. PubMed: 15665276 MGI: J:95440
Paolella BR; Havrda MC; Mantani A; Wray CM; Zhang Z; Israel MA. 2011. p53 directly represses Id2 to inhibit the proliferation of neural progenitor cells. Stem Cells 29(7):1090-101. PubMed: 21608079 MGI: J:190209
Parant J; Chavez-Reyes A; Little NA; Yan W; Reinke V; Jochemsen AG; Lozano G. 2001. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 29(1):92-5. PubMed: 11528400 MGI: J:71532
Park HJ; Hong M; Bronson RT; Israel MA; Frankel WN; Yun K. 2013. Elevated id2 expression results in precocious neural stem cell depletion and abnormal brain development. Stem Cells 31(5):1010-21. PubMed: 23390122 MGI: J:196308
Park IY; Sohn BH; Choo JH; Joe CO; Seong JK; Lee YI; Chung JH. 2005. Deregulation of DNA methyltransferases and loss of parental methylation at the insulin-like growth factor II (Igf2)/H19 loci in p53 knockout mice prior to tumor development. J Cell Biochem 94(3):585-96. PubMed: 15543560 MGI: J:95902
Patmore DM; Welch S; Fulkerson PC; Wu J; Choi K; Eaves D; Kordich JJ; Collins MH; Cripe TP; Ratner N. 2012. In vivo regulation of TGF-beta by R-Ras2 revealed through loss of the RasGAP protein NF1. Cancer Res 72(20):5317-27. PubMed: 22918885 MGI: J:191804
Payne AW; Pant DK; Pan TC; Chodosh LA. 2014. Ceramide kinase promotes tumor cell survival and mammary tumor recurrence. Cancer Res 74(21):6352-63. PubMed: 25164007 MGI: J:216698
Pedraza-Alva G; Koulnis M; Charland C; Thornton T; Clements JL; Schlissel MS; Rincon M. 2006. Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint. EMBO J 25(4):763-73. PubMed: 16456545 MGI: J:105987
Pei L; Shang Y; Jin H; Wang S; Wei N; Yan H; Wu Y; Yao C; Wang X; Zhu LQ; Lu Y. 2014. DAPK1-p53 interaction converges necrotic and apoptotic pathways of ischemic neuronal death. J Neurosci 34(19):6546-56. PubMed: 24806680 MGI: J:211044
Pei XH; Bai F; Li Z; Smith MD; Whitewolf G; Jin R; Xiong Y. 2011. Cytoplasmic CUL9/PARC Ubiquitin Ligase Is a Tumor Suppressor and Promotes p53-Dependent Apoptosis. Cancer Res 71(8):2969-77. PubMed: 21487039 MGI: J:170976
Peintner L; Dorstyn L; Kumar S; Aneichyk T; Villunger A; Manzl C. 2015. The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd. Cell Death Differ 22(11):1803-11. PubMed: 25857265 MGI: J:256664
Pekar O; Molotski N; Savion S; Fein A; Toder V; Torchinsky A. 2007. p53 regulates cyclophosphamide teratogenesis by controlling caspases 3, 8, 9 activation and NF-{kappa}B DNA binding. Reproduction 134(2):379-88. PubMed: 17660247 MGI: J:123339
Perera SA; Maser RS; Xia H; McNamara K; Protopopov A; Chen L; Hezel AF; Kim CF; Bronson RT; Castrillon DH; Chin L; Bardeesy N; Depinho RA; Wong KK. 2008. Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. Carcinogenesis 29(4):747-53. PubMed: 18283039 MGI: J:133322
Perez-Mancera PA; Perez-Caro M; Gonzalez-Herrero I; Flores T; Orfao A; de Herreros AG; Gutierrez-Adan A; Pintado B; Sagrera A; Sanchez-Martin M; Sanchez-Garcia I. 2005. Cancer development induced by graded expression of Snail in mice. Hum Mol Genet 14(22):3449-61. PubMed: 16207734 MGI: J:104124
Pestina TI; Cleveland JL; Yang C; Zambetti GP; Jackson CW. 2001. Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis. Blood 98(7):2084-90. PubMed: 11567994 MGI: J:115633
Petrenko O; Moll UM. 2005. Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway. Mol Cell 17(2):225-36. PubMed: 15664192 MGI: J:95692
Peuscher MH; Jacobs JJ. 2011. DNA-damage response and repair activities at uncapped telomeres depend on RNF8. Nat Cell Biol 13(9):1139-45. PubMed: 21857671 MGI: J:176962
Pfefferle AD; Herschkowitz JI; Usary J; Harrell JC; Spike BT; Adams JR; Torres-Arzayus MI; Brown M; Egan SE; Wahl GM; Rosen JM; Perou CM. 2013. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol 14(11):R125. PubMed: 24220145 MGI: J:227323
Phoenix TN; Patmore DM; Boop S; Boulos N; Jacus MO; Patel YT; Roussel MF; Finkelstein D; Goumnerova L; Perreault S; Wadhwa E; Cho YJ; Stewart CF; Gilbertson RJ. 2016. Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype. Cancer Cell 29(4):508-22. PubMed: 27050100 MGI: J:231825
Pilaz LJ; McMahon JJ; Miller EE; Lennox AL; Suzuki A; Salmon E; Silver DL. 2016. Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain. Neuron 89(1):83-99. PubMed: 26748089 MGI: J:230878
Pinto M; Pickrell AM; Wang X; Bacman SR; Yu A; Hida A; Dillon LM; Morton PD; Malek TR; Williams SL; Moraes CT. 2017. Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner. Cell Death Differ 24(2):288-299. PubMed: 27911443 MGI: J:258549
Plummer NW; Gallione CJ; Srinivasan S; Zawistowski JS; Louis DN; Marchuk DA. 2004. Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations. Am J Pathol 165(5):1509-18. PubMed: 15509522 MGI: J:93631
Po A; Ferretti E; Miele E; De Smaele E; Paganelli A; Canettieri G; Coni S; Di Marcotullio L; Biffoni M; Massimi L; Di Rocco C; Screpanti I; Gulino A. 2010. Hedgehog controls neural stem cells through p53-independent regulation of Nanog. EMBO J 29(15):2646-58. PubMed: 20581804 MGI: J:163390
Podsypanina K; Li Y; Varmus HE. 2004. Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype. BMC Med 2(1):24. PubMed: 15198801 MGI: J:91649
Polato F; Rusconi P; Zangrossi S; Morelli F; Boeri M; Musi A; Marchini S; Castiglioni V; Scanziani E; Torri V; Broggini M. 2014. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosupprossor. J Natl Cancer Inst 106(4):dju053. PubMed: 24652652 MGI: J:210814
Politi K; Fan PD; Shen R; Zakowski M; Varmus H. 2010. Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma. Dis Model Mech 3(1-2):111-9. PubMed: 20007486 MGI: J:157671
Politi K; Zakowski MF; Fan PD; Schonfeld EA; Pao W; Varmus HE. 2006. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev 20(11):1496-510. PubMed: 16705038 MGI: J:109092
Popowich DA; Vavra AK; Walsh CP; Bhikhapurwala HA; Rossi NB; Jiang Q; Aalami OO; Kibbe MR. 2010. Regulation of reactive oxygen species by p53: implications for nitric oxide-mediated apoptosis. Am J Physiol Heart Circ Physiol 298(6):H2192-200. PubMed: 20382856 MGI: J:160340
Porteiro B; Diaz-Ruiz A; Martinez G; Senra A; Vidal A; Serrano M; Gualillo O; Lopez M; Malagon MM; Dieguez C; Nogueiras R. 2013. Ghrelin requires p53 to stimulate lipid storage in fat and liver. Endocrinology 154(10):3671-9. PubMed: 23832961 MGI: J:203303
Post SM; Quintas-Cardama A; Terzian T; Smith C; Eischen CM; Lozano G. 2010. p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis. Oncogene 29(9):1260-9. PubMed: 19935700 MGI: J:168278
Prasher JM; Elenitoba-Johnson KS; Kelley LL. 2001. Loss of p53 tumor suppressor function is required for in vivo progression of Friend erythroleukemia. Oncogene 20(23):2946-55. PubMed: 11420707 MGI: J:124424
Prives C; Manfredi JJ. 1993. The p53 tumor suppressor protein: meeting review. Genes Dev 7(4):529-34. PubMed: 8096197 MGI: J:16023
Qi Q; Huang W; Bai Y; Balmus G; Weiss RS; August A. 2012. A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice. J Immunol 188(8):3611-9. PubMed: 22403441 MGI: J:184083
Qiang L; Kon N; Zhao W; Jiang L; Knight CM; Welch C; Pajvani U; Gu W; Accili D. 2015. Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. Cell Rep 11(11):1797-808. PubMed: 26074075 MGI: J:228688
Qiu J; Takagi Y; Harada J; Rodrigues N; Moskowitz MA; Scadden DT; Cheng T. 2004. Regenerative response in ischemic brain restricted by p21cip1/waf1. J Exp Med 199(7):937-45. PubMed: 15067031 MGI: J:90479
Qiu W; Carson-Walter EB; Liu H; Epperly M; Greenberger JS; Zambetti GP; Zhang L; Yu J. 2008. PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell 2(6):576-83. PubMed: 18522850 MGI: J:149798
Qiu W; Wu B; Wang X; Buchanan ME; Regueiro MD; Hartman DJ; Schoen RE; Yu J; Zhang L. 2011. PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. J Clin Invest 121(5):1722-32. PubMed: 21490394 MGI: J:173951
Rajkumar L; Kittrell FS; Guzman RC; Brown PH; Nandi S; Medina D. 2007. Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models. Breast Cancer Res 9(1):R12. PubMed: 17257424 MGI: J:121486
Ramsey MR; Wilson C; Ory B; Rothenberg SM; Faquin W; Mills AA; Ellisen LW. 2013. FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma. J Clin Invest 123(8):3525-38. PubMed: 23867503 MGI: J:201403
Rashkovan M; Vadnais C; Ross J; Gigoux M; Suh WK; Gu W; Kosan C; Moroy T. 2014. Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination. Proc Natl Acad Sci U S A 111(50):E5411-9. PubMed: 25468973 MGI: J:217809
Redmond WL; Wei CH; Kreuwel HT; Sherman LA. 2008. The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen. J Immunol 180(8):5275-82. PubMed: 18390708 MGI: J:134242
Reiling E; Speksnijder EN; Pronk AC; van den Berg SA; Neggers SJ; Rietbroek I; van Steeg H; Dolle ME. 2014. Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition. Sci Rep 4:4091. PubMed: 24522546 MGI: J:207466
Reilly KM; Broman KW; Bronson RT; Tsang S; Loisel DA; Christy ES; Sun Z; Diehl J; Munroe DJ; Tuskan RG. 2006. An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model. Cancer Res 66(1):62-8. PubMed: 16397217 MGI: J:105038
Reilly KM; Loisel DA; Bronson RT; McLaughlin ME; Jacks T. 2000. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects Nat Genet 26(1):109-13. PubMed: 10973261 MGI: J:64364
Reilly KM; Tuskan RG; Christy E; Loisel DA; Ledger J; Bronson RT; Smith CD; Tsang S; Munroe DJ; Jacks T. 2004. Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. Proc Natl Acad Sci U S A 101(35):13008-13. PubMed: 15319471 MGI: J:92444
Reimann M; Lee S; Loddenkemper C; Dorr JR; Tabor V; Aichele P; Stein H; Dorken B; Jenuwein T; Schmitt CA. 2010. Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence. Cancer Cell 17(3):262-72. PubMed: 20227040 MGI: J:158660
Reinke V; Lozano G. 1997. The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo. Oncogene 15(13):1527-34. PubMed: 9380404 MGI: J:43292
Reis AM; Cheo DL; Meira LB; Greenblatt MS; Bond JP; Nahari D; Friedberg EC. 2000. Genotype-specific Trp53 mutational analysis in ultraviolet B radiation-induced skin cancers in Xpc and Xpc Trp53 mutant mice Cancer Res 60(6):1571-9. PubMed: 10749125 MGI: J:61422
Ricke EA; Williams K; Lee YF; Couto S; Wang Y; Hayward SW; Cunha GR; Ricke WA. 2012. Androgen hormone action in prostatic carcinogenesis: stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis. Carcinogenesis 33(7):1391-8. PubMed: 22535887 MGI: J:190775
Rigby CM; Roy S; Deep G; Guillermo-Lagae R; Jain AK; Dhar D; Orlicky DJ; Agarwal C; Agarwal R. 2017. Role of p53 in silibinin-mediated inhibition of ultraviolet B radiation-induced DNA damage, inflammation and skin carcinogenesis. Carcinogenesis 38(1):40-50. PubMed: 27729375 MGI: J:237933
Rinon A; Molchadsky A; Nathan E; Yovel G; Rotter V; Sarig R; Tzahor E. 2011. p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes. Development 138(9):1827-38. PubMed: 21447558 MGI: J:171272
Robbiani DF; Bunting S; Feldhahn N; Bothmer A; Camps J; Deroubaix S; McBride KM; Klein IA; Stone G; Eisenreich TR; Ried T; Nussenzweig A; Nussenzweig MC. 2009. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell 36(4):631-41. PubMed: 19941823 MGI: J:154731
Rodriguez-Diez E; Quereda V; Bellutti F; Prchal-Murphy M; Partida D; Eguren M; Kollmann K; Gomez de Cedron M; Dubus P; Canamero M; Martinez D; Sexl V; Malumbres M. 2014. Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis. Blood 124(15):2380-90. PubMed: 25157181 MGI: J:218704
Romer JT; Kimura H; Magdaleno S; Sasai K; Fuller C; Baines H; Connelly M; Stewart CF; Gould S; Rubin LL; Curran T. 2004. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell 6(3):229-40. PubMed: 15380514 MGI: J:93535
Rosario CO; Ko MA; Haffani YZ; Gladdy RA; Paderova J; Pollett A; Squire JA; Dennis JW; Swallow CJ. 2010. Plk4 is required for cytokinesis and maintenance of chromosomal stability. Proc Natl Acad Sci U S A 107(15):6888-93. PubMed: 20348415 MGI: J:159310
Rose-Hellekant TA; Schroeder MD; Brockman JL; Zhdankin O; Bolstad R; Chen KS; Gould MN; Schuler LA; Sandgren EP. 2007. Estrogen receptor-positive mammary tumorigenesis in TGFalpha transgenic mice progresses with progesterone receptor loss. Oncogene 26(36):5238-46. PubMed: 17334393 MGI: J:137737
Rossiello F; Aguado J; Sepe S; Iannelli F; Nguyen Q; Pitchiaya S; Carninci P; d'Adda di Fagagna F. 2017. DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs. Nat Commun 8(None):13980. PubMed: 28239143 MGI: J:244011
Roth I; Campbell H; Rubio C; Vennin C; Wilson M; Wiles A; Williams G; Woolley A; Timpson P; Berridge MV; Fleming N; Baird M; Braithwaite AW. 2016. The Delta133p53 isoform and its mouse analogue Delta122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2. Oncogene :. PubMed: 26996665 MGI: J:230790
Roudier E; Forn P; Perry ME; Birot O. 2012. Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle. FASEB J 26(11):4530-9. PubMed: 22835827 MGI: J:192387
Ruland J; Sirard C; Elia A; MacPherson D; Wakeham A; Li L; de la Pompa JL; Cohen SN; Mak TW. 2001. p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101. Proc Natl Acad Sci U S A 98(4):1859-64. PubMed: 11172041 MGI: J:67553
Russell TD; Yan Q; Fan G; Khalifah AP; Bishop DK; Brody SL; Walter MJ. 2003. IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta1. J Immunol 171(12):6866-74. PubMed: 14662893 MGI: J:86929
Ruzankina Y; Schoppy DW; Asare A; Clark CE; Vonderheide RH; Brown EJ. 2009. Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53. Nat Genet 41(10):1144-9. PubMed: 19718024 MGI: J:155013
Sah VP; Attardi LD; Mulligan GJ; Williams BO; Bronson RT; Jacks T. 1995. A subset of p53-deficient embryos exhibit exencephaly. Nat Genet 10(2):175-80. PubMed: 7663512 MGI: J:23197
Saifudeen Z; Dipp S; El-Dahr SS. 2002. A role for p53 in terminal epithelial cell differentiation. J Clin Invest 109(8):1021-30. PubMed: 11956239 MGI: J:112023
Saifudeen Z; Dipp S; Stefkova J; Yao X; Lookabaugh S; El-Dahr SS. 2009. p53 regulates metanephric development. J Am Soc Nephrol 20(11):2328-37. PubMed: 19729440 MGI: J:166316
Saifudeen Z; Liu J; Dipp S; Yao X; Li Y; McLaughlin N; Aboudehen K; El-Dahr SS. 2012. A p53-Pax2 pathway in kidney development: implications for nephrogenesis. PLoS One 7(9):e44869. PubMed: 22984579 MGI: J:192892
Salazar G; Joshi A; Liu D; Wei H; Persson JL; Wolgemuth DJ. 2005. Induction of apoptosis involving multiple pathways is a primary response to cyclin A1-deficiency in male meiosis. Dev Dyn 234(1):114-23. PubMed: 16086332 MGI: J:100237
Samper E; Morgado L; Estrada JC; Bernad A; Hubbard A; Cadenas S; Melov S. 2009. Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med 46(3):387-96. PubMed: 19038329 MGI: J:143530
Sanchez-Macedo N; Feng J; Faubert B; Chang N; Elia A; Rushing EJ; Tsuchihara K; Bungard D; Berger SL; Jones RG; Mak TW; Zaugg K. 2013. Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model. Cell Death Differ 20(4):659-68. PubMed: 23412344 MGI: J:228258
Sano M; Minamino T; Toko H; Miyauchi H; Orimo M; Qin Y; Akazawa H; Tateno K; Kayama Y; Harada M; Shimizu I; Asahara T; Hamada H; Tomita S; Molkentin JD; Zou Y; Komuro I. 2007. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446(7134):444-8. PubMed: 17334357 MGI: J:120332
Santidrian AF; Gonzalez-Girones DM; Iglesias-Serret D; Coll-Mulet L; Cosialls AM; de Frias M; Campas C; Gonzalez-Barca E; Alonso E; Labi V; Viollet B; Benito A; Pons G; Villunger A; Gil J. 2010. AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. Blood 116(16):3023-32. PubMed: 20664053 MGI: J:165862
Sasaki M; Kawahara K; Nishio M; Mimori K; Kogo R; Hamada K; Itoh B; Wang J; Komatsu Y; Yang YR; Hikasa H; Horie Y; Yamashita T; Kamijo T; Zhang Y; Zhu Y; Prives C; Nakano T; Mak TW; Sasaki T; Maehama T; Mori M; Suzuki A. 2011. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med 17(8):944-51. PubMed: 21804542 MGI: J:241062
Sato S; Tang YJ; Wei Q; Hirata M; Weng A; Han I; Okawa A; Takeda S; Whetstone H; Nadesan P; Kirsch DG; Wunder JS; Alman BA. 2016. Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with beta-Catenin Modulating the Neoplastic Phenotype. Cell Rep 16(4):917-27. PubMed: 27425618 MGI: J:238661
Saunders DN; Hird SL; Withington SL; Dunwoodie SL; Henderson MJ; Biben C; Sutherland RL; Ormandy CJ; Watts CK. 2004. Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion. Mol Cell Biol 24(16):7225-34. PubMed: 15282321 MGI: J:92269
Sawhney S; Hood K; Shaw A; Braithwaite AW; Stubbs R; Hung NA; Royds JA; Slatter TL. 2015. Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a 133p53alpha mimic. PLoS One 10(2):e0116270. PubMed: 25643152 MGI: J:229054
Sayin VI; Khan OM; Pehlivanoglu LE; Staffas A; Ibrahim MX; Asplund A; Agren P; Nilton A; Bergstrom G; Bergo MO; Boren J; Lindahl P. 2014. Loss of one copy of Zfp148 reduces lesional macrophage proliferation and atherosclerosis in mice by activating p53. Circ Res 115(9):781-9. PubMed: 25212213 MGI: J:226877
Sayin VI; Nilton A; Ibrahim MX; Agren P; Larsson E; Petit MM; Hulten LM; Stahlman M; Johansson BR; Bergo MO; Lindahl P. 2013. Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment. PLoS One 8(2):e55720. PubMed: 23405202 MGI: J:198319
Schaetzlein S; Chahwan R; Avdievich E; Roa S; Wei K; Eoff RL; Sellers RS; Clark AB; Kunkel TA; Scharff MD; Edelmann W. 2013. Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proc Natl Acad Sci U S A 110(27):E2470-9. PubMed: 23754438 MGI: J:198719
Schmidt NW; Mayo LD; Donner DB; Kaplan MH. 2006. p53 regulates Btk-dependent B cell proliferation but not differentiation. J Leukoc Biol 79(4):852-9. PubMed: 16461747 MGI: J:107548
Schmitt CA; Fridman JS; Yang M; Baranov E; Hoffman RM; Lowe SW. 2002. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 1(3):289-98. PubMed: 12086865 MGI: J:77133
Schmitt CA; Fridman JS; Yang M; Lee S; Baranov E; Hoffman RM; Lowe SW. 2002. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109(3):335-46. PubMed: 12015983 MGI: J:76474
Schmitt CA; McCurrach ME; de Stanchina E; Wallace-Brodeur RR; Lowe SW. 1999. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev 13(20):2670-7. PubMed: 10541553 MGI: J:58293
Schmitt CA; Wallace-Brodeur RR; Rosenthal CT; McCurrach ME; Lowe SW. 2000. DNA damage responses and chemosensitivity in the E mu-myc mouse lymphoma model. Cold Spring Harb Symp Quant Biol 65:499-510. PubMed: 12760067 MGI: J:84207
Schneider JE; Bose J; Bamforth SD; Gruber AD; Broadbent C; Clarke K; Neubauer S; Lengeling A; Bhattacharya S. 2004. Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol 4(1):16. PubMed: 15615595 MGI: J:102098
Schober CS; Aydiner F; Booth CJ; Seli E; Reinke V. 2011. The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis. Mech Dev 128(3-4):178-90. PubMed: 21277975 MGI: J:171525
Schonhuber N; Seidler B; Schuck K; Veltkamp C; Schachtler C; Zukowska M; Eser S; Feyerabend TB; Paul MC; Eser P; Klein S; Lowy AM; Banerjee R; Yang F; Lee CL; Moding EJ; Kirsch DG; Scheideler A; Alessi DR; Varela I; Bradley A; Kind A; Schnieke AE; Rodewald HR; Rad R; Schmid RM; Schneider G; Saur D. 2014. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med 20(11):1340-7. PubMed: 25326799 MGI: J:218155
Schoppy DW; Ragland RL; Gilad O; Shastri N; Peters AA; Murga M; Fernandez-Capetillo O; Diehl JA; Brown EJ. 2012. Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR. J Clin Invest 122(1):241-52. PubMed: 22133876 MGI: J:184414
Schramek D; Kotsinas A; Meixner A; Wada T; Elling U; Pospisilik JA; Neely GG; Zwick RH; Sigl V; Forni G; Serrano M; Gorgoulis VG; Penninger JM. 2011. The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet 43(3):212-9. PubMed: 21317887 MGI: J:170904
Schreiner B; Baur DM; Fingerle AA; Zechner U; Greten FR; Adler G; Sipos B; Kloppel G; Hameister H; Schmid RM. 2003. Pattern of secondary genomic changes in pancreatic tumors of Tgfalpha/Trp53+/- transgenic mice. Genes Chromosomes Cancer 38(3):240-8. PubMed: 14506698 MGI: J:85920
Schuster C; Berger A; Hoelzl MA; Putz EM; Frenzel A; Simma O; Moritz N; Hoelbl A; Kovacic B; Freissmuth M; Muller M; Villunger A; Mullauer L; Schmatz AI; Streubel B; Porpaczy E; Jager U; Stoiber D; Sexl V. 2011. The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas. Blood 118(17):4635-45. PubMed: 21878673 MGI: J:178381
Schwarzkopf M; Coletti D; Sassoon D; Marazzi G. 2006. Muscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway. Genes Dev 20(24):3440-52. PubMed: 17182869 MGI: J:116682
Scoggins CR; Meszoely IM; Wada M; Means AL; Yang L; Leach SD. 2000. p53-dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas Am J Physiol Gastrointest Liver Physiol 279(5):G827-36. PubMed: 11005771 MGI: J:65224
Scott CL; Gil J; Hernando E; Teruya-Feldstein J; Narita M; Martinez D; Visakorpi T; Mu D; Cordon-Cardo C; Peters G; Beach D; Lowe SW. 2007. Role of the chromobox protein CBX7 in lymphomagenesis. Proc Natl Acad Sci U S A 104(13):5389-94. PubMed: 17374722 MGI: J:120126
Seah C; Levy MA; Jiang Y; Mokhtarzada S; Higgs DR; Gibbons RJ; Berube NG. 2008. Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53. J Neurosci 28(47):12570-80. PubMed: 19020049 MGI: J:142359
Secchiero P; Corallini F; Rimondi E; Chiaruttini C; di Iasio MG; Rustighi A; Del Sal G; Zauli G. 2008. Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells. Blood 111(3):1287-94. PubMed: 18000166 MGI: J:130770
Seitz U; Wagner M; Vogg AT; Glatting G; Neumaier B; Greten FR; Schmid RM; Reske SN. 2001. In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model. Cancer Res 61(10):3853-7. PubMed: 11358795 MGI: J:69189
Semont A; Nowak EB; Silva Lages C; Mathieu C; Mouthon MA; May E; Allemand I; Millet P; Boussin FD. 2004. Involvement of p53 and Fas/CD95 in murine neural progenitor cell response to ionizing irradiation. Oncogene 23(52):8497-508. PubMed: 15361846 MGI: J:93854
Senoo M; Manis JP; Alt FW; McKeon F. 2004. p63 and p73 are not required for the development and p53-dependent apoptosis of T cells. Cancer Cell 6(1):85-9. PubMed: 15261144 MGI: J:115491
Sernandez IV; de Yebenes VG; Dorsett Y; Ramiro AR. 2008. Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo. PLoS One 3(12):e3927. PubMed: 19079594 MGI: J:144360
Serrano M; Lin AW; McCurrach ME; Beach D; Lowe SW. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88(5):593-602. PubMed: 9054499 MGI: J:118586
Sfeir A; Kabir S; van Overbeek M; Celli GB; de Lange T. 2010. Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327(5973):1657-61. PubMed: 20339076 MGI: J:158884
Sfeir A; de Lange T. 2012. Removal of shelterin reveals the telomere end-protection problem. Science 336(6081):593-7. PubMed: 22556254 MGI: J:184522
Shakya A; Cooksey R; Cox JE; Wang V; McClain DA; Tantin D. 2009. Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol 11(3):320-7. PubMed: 19219035 MGI: J:158059
Shao C; Deng L; Henegariu O; Liang L; Stambrook PJ; Tischfield JA. 2000. Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Proc Natl Acad Sci U S A 97(13):7405-10. PubMed: 10861008 MGI: J:63074
Shao L; Sun Y; Zhang Z; Feng W; Gao Y; Cai Z; Wang ZZ; Look AT; Wu WS. 2010. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood 115(23):4707-14. PubMed: 20360471 MGI: J:161544
Sharma A; Sen JM. 2013. Molecular basis for the tissue specificity of beta-catenin oncogenesis. Oncogene 32(15):1901-9. PubMed: 22689057 MGI: J:197228
Sharpless NE. 2005. INK4a/ARF: a multifunctional tumor suppressor locus. Mutat Res 576(1-2):22-38. PubMed: 15878778 MGI: J:100600
Sharpless NE; Alson S; Chan S; Silver DP; Castrillon DH; DePinho RA. 2002. p16(INK4a) and p53 deficiency cooperate in tumorigenesis. Cancer Res 62(10):2761-5. PubMed: 12019151 MGI: J:76652
Sheikh BN; Lee SC; El-Saafin F; Vanyai HK; Hu Y; Pang SH; Grabow S; Strasser A; Nutt SL; Alexander WS; Smyth GK; Voss AK; Thomas T. 2015. MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development. Blood 125(12):1910-21. PubMed: 25605372 MGI: J:221399
Shen Q; Brown PH. 2005. Transgenic mouse models for the prevention of breast cancer. Mutat Res 576(1-2):93-110. PubMed: 15888345 MGI: J:100623
Shetty G; Shao SH; Weng CC. 2008. p53-dependent apoptosis in the inhibition of spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice. Endocrinology 149(6):2773-81. PubMed: 18356279 MGI: J:136072
Shibata MA; Liu ML; Knudson MC; Shibata E; Yoshidome K; Bandey T ; Korsmeyer SJ ; Green JE. 1999. Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage. EMBO J 18(10):2692-701. PubMed: 10329616 MGI: J:55778
Shu Z; Smith S; Wang L; Rice MC; Kmiec EB. 1999. Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can Be partially rescued in a p53(-/-) background. Mol Cell Biol 19(12):8686-93. PubMed: 10567591 MGI: J:58601
Shukla PC; Singh KK; Quan A; Al-Omran M; Teoh H; Lovren F; Cao L; Rovira II; Pan Y; Brezden-Masley C; Yanagawa B; Gupta A; Deng CX; Coles JG; Leong-Poi H; Stanford WL; Parker TG; Schneider MD; Finkel T; Verma S. 2011. BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat Commun 2:593. PubMed: 22186889 MGI: J:205643
Sicinska E; Aifantis I; Le Cam L; Swat W; Borowski C; Yu Q; Ferrando AA; Levin SD; Geng Y; von Boehmer H; Sicinski P. 2003. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4(6):451-61. PubMed: 14706337 MGI: J:88120
Siggs OM; Stockenhuber A; Deobagkar-Lele M; Bull KR; Crockford TL; Kingston BL; Crawford G; Anzilotti C; Steeples V; Ghaffari S; Czibik G; Bellahcene M; Watkins H; Ashrafian H; Davies B; Woods A; Carling D; Yavari A; Beutler B; Cornall RJ. 2016. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proc Natl Acad Sci U S A 113(26):E3706-15. PubMed: 27303042 MGI: J:234285
Signer RA; Magee JA; Salic A; Morrison SJ. 2014. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature 509(7498):49-54. PubMed: 24670665 MGI: J:210464
Silvestre DC; Gil GA; Tomasini N; Bussolino DF; Caputto BL. 2010. Growth of peripheral and central nervous system tumors is supported by cytoplasmic c-Fos in humans and mice. PLoS One 5(3):e9544. PubMed: 20209053 MGI: J:158701
Simin K; Hill R; Song Y; Zhang Q; Bash R; Cardiff RD; Yin C; Xiao A; McCarthy K; van Dyke T. 2005. Deciphering cancer complexities in genetically engineered mice. Cold Spring Harb Symp Quant Biol 70:283-90. PubMed: 16869764 MGI: J:116748
Simin K; Wu H; Lu L; Pinkel D; Albertson D; Cardiff RD; Dyke TV. 2004. pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia. PLoS Biol 2(2):E22. PubMed: 14966529 MGI: J:88315
Simpson KJ; Wati MR; Deans AJ; Lindeman GJ; Brown MA. 2004. MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development. Int J Dev Biol 48(7):675-8. PubMed: 15470641 MGI: J:100051
Singh N; Yamamoto M; Takami M; Seki Y; Takezaki M; Mellor AL; Iwashima M. 2010. CD4(+)CD25(+) regulatory T cells resist a novel form of CD28- and Fas-dependent p53-induced T cell apoptosis. J Immunol 184(1):94-104. PubMed: 19949106 MGI: J:159002
Singh S; Vaughan CA; Frum RA; Grossman SR; Deb S; Palit Deb S. 2017. Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication. J Clin Invest 127(5):1839-1855. PubMed: 28394262 MGI: J:243964
Singh S; Vinson C; Gurley CM; Nolen GT; Beggs ML; Nagarajan R; Wagner EF; Parham DM; Peterson CA. 2010. Impaired Wnt signaling in embryonal rhabdomyosarcoma cells from p53/c-fos double mutant mice. Am J Pathol 177(4):2055-66. PubMed: 20829439 MGI: J:165430
Singh SK; Chen NM; Hessmann E; Siveke J; Lahmann M; Singh G; Voelker N; Vogt S; Esposito I; Schmidt A; Brendel C; Stiewe T; Gaedcke J; Mernberger M; Crawford HC; Bamlet WR; Zhang JS; Li XK; Smyrk TC; Billadeau DD; Hebrok M; Neesse A; Koenig A; Ellenrieder V. 2015. Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity. EMBO J 34(4):517-30. PubMed: 25586376 MGI: J:219268
Siu KT; Xu Y; Swartz KL; Bhattacharyya M; Gurbuxani S; Hua Y; Minella AC. 2014. Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation. Mol Cell Biol 34(17):3244-58. PubMed: 24958101 MGI: J:224269
Skowronska-Krawczyk D; Zhao L; Zhu J; Weinreb RN; Cao G; Luo J; Flagg K; Patel S; Wen C; Krupa M; Luo H; Ouyang H; Lin D; Wang W; Li G; Xu Y; Li O; Chung C; Yeh E; Jafari M; Ai M; Zhong Z; Shi W; Zheng L; Krawczyk M; Chen D; Shi C; Zin C; Zhu J; Mellon PL; Gao W; Abagyan R; Zhang L; Sun X; Zhong S; Zhuo Y; Rosenfeld MG; Liu Y; Zhang K. 2015. P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Mol Cell 59(6):931-40. PubMed: 26365380 MGI: J:228087
Slatter TL; Ganesan P; Holzhauer C; Mehta R; Rubio C; Williams G; Wilson M; Royds JA; Baird MA; Braithwaite AW. 2010. p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death Differ 17(3):540-50. PubMed: 19779492 MGI: J:169434
Slatter TL; Hung N; Campbell H; Rubio C; Mehta R; Renshaw P; Williams G; Wilson M; Engelmann A; Jeffs A; Royds JA; Baird MA; Braithwaite AW. 2011. Hyperproliferation, cancer, and inflammation in mice expressing a Delta133p53-like isoform. Blood 117(19):5166-77. PubMed: 21411755 MGI: J:173271
Smiraldo PG; Gruver AM; Osborn JC; Pittman DL. 2005. Extensive chromosomal instability in Rad51d-deficient mouse cells. Cancer Res 65(6):2089-96. PubMed: 15781618 MGI: J:97153
Smith MI; Deshmukh M. 2007. Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons. Cell Death Differ 14(5):1011-9. PubMed: 17218955 MGI: J:139276
Smith RS; Miller JV; Sundberg JP. 2002. Intraocular teratoma in a mouse. Comp Med 52(1):68-72. PubMed: 11900416 MGI: J:75056
Smits R; van der Houven van Oordt W; Luz A; Zurcher C; Jagmohan-Changur S ; Breukel C ; Khan PM ; Fodde R. 1998. Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. Gastroenterology 114(2):275-83. PubMed: 9453487 MGI: J:46025
Song S; Lambert PF. 1999. Different responses of epidermal and hair follicular cells to radiation correlate with distinct patterns of p53 and p21 induction. Am J Pathol 155(4):1121-7. PubMed: 10514395 MGI: J:114161
Sotillo R; Dubus P; Martin J; de la Cueva E; Ortega S; Malumbres M; Barbacid M. 2001. Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J 20(23):6637-47. PubMed: 11726500 MGI: J:73034
Spehlmann ME; Manthey CF; Dann SM; Hanson E; Sandhu SS; Liu LY; Abdelmalak FK; Diamanti MA; Retzlaff K; Scheller J; Rose-John S; Greten FR; Wang JY; Eckmann L. 2013. Trp53 deficiency protects against acute intestinal inflammation. J Immunol 191(2):837-47. PubMed: 23772033 MGI: J:204954
Sridevi P; Nhiayi MK; Wang JY. 2013. Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity. Cell Death Differ 20(7):953-62. PubMed: 23660976 MGI: J:221235
Stadanlick JE; Zhang Z; Lee SY; Hemann M; Biery M; Carleton MO; Zambetti GP; Anderson SJ; Oravecz T; Wiest DL. 2011. Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors. J Immunol 187(2):664-75. PubMed: 21690328 MGI: J:178024
Stanger BZ; Stiles B; Lauwers GY; Bardeesy N; Mendoza M; Wang Y; Greenwood A; Cheng KH; McLaughlin M; Brown D; Depinho RA; Wu H; Melton DA; Dor Y. 2005. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 8(3):185-95. PubMed: 16169464 MGI: J:102226
Steckley D; Karajgikar M; Dale LB; Fuerth B; Swan P; Drummond-Main C; Poulter MO; Ferguson SS; Strasser A; Cregan SP. 2007. Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci 27(47):12989-99. PubMed: 18032672 MGI: J:127640
Stedman A; Beck-Cormier S; Le Bouteiller M; Raveux A; Vandormael-Pournin S; Coqueran S; Lejour V; Jarzebowski L; Toledo F; Robine S; Cohen-Tannoudji M. 2015. Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells. Cell Death Differ 22(11):1865-76. PubMed: 26068591 MGI: J:258554
Steele-Perkins G; Fang W; Yang XH; Van Gele M; Carling T; Gu J; Buyse IM; Fletcher JA; Liu J; Bronson R; Chadwick RB; de la Chapelle A; Zhang X; Speleman F; Huang S. 2001. Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily. Genes Dev 15(17):2250-62. PubMed: 11544182 MGI: J:71406
Stoddart A; Wang J; Fernald AA; Karrison T; Anastasi J; Le Beau MM. 2014. Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc. Blood 123(2):228-38. PubMed: 24264229 MGI: J:208082
Stracker TH; Couto SS; Cordon-Cardo C; Matos T; Petrini JH. 2008. Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell 31(1):21-32. PubMed: 18614044 MGI: J:138550
Stromblad S; Fotedar A; Brickner H; Theesfeld C; Aguilar de Diaz E; Friedlander M; Cheresh DA. 2002. Loss of p53 compensates for alpha v-integrin function in retinal neovascularization. J Biol Chem 277(16):13371-4. PubMed: 11856728 MGI: J:124691
Su X; Chakravarti D; Cho MS; Liu L; Gi YJ; Lin YL; Leung ML; El-Naggar A; Creighton CJ; Suraokar MB; Wistuba I; Flores ER. 2010. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature 467(7318):986-90. PubMed: 20962848 MGI: J:165549
Su X; Chakravarti D; Flores ER. 2013. p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer 13(2):136-43. PubMed: 23344544 MGI: J:193489
Su X; Cho MS; Gi YJ; Ayanga BA; Sherr CJ; Flores ER. 2009. Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBO J 28(13):1904-15. PubMed: 19494829 MGI: J:150850
Su X; Paris M; Gi YJ; Tsai KY; Cho MS; Lin YL; Biernaskie JA; Sinha S; Prives C; Pevny LH; Miller FD; Flores ER. 2009. TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5(1):64-75. PubMed: 19570515 MGI: J:151638
Sugo N; Niimi N; Aratani Y; Takiguchi-Hayashi K; Koyama H. 2004. p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice. Mol Cell Biol 24(21):9470-7. PubMed: 15485914 MGI: J:94157
Suh EK; Yang A; Kettenbach A; Bamberger C; Michaelis AH; Zhu Z; Elvin JA; Bronson RT; Crum CP; McKeon F. 2006. p63 protects the female germ line during meiotic arrest. Nature 444(7119):624-8. PubMed: 17122775 MGI: J:116176
Suh YA; Post SM; Elizondo-Fraire AC; Maccio DR; Jackson JG; El-Naggar AK; Van Pelt C; Terzian T; Lozano G. 2011. Multiple Stress Signals Activate Mutant p53 In Vivo. Cancer Res 71(23):7168-75. PubMed: 21983037 MGI: J:178850
Summers BA. 2004. Pathology annotation source Personal Communication :. MGI: J:94335
Sun Z; Huang C; He J; Lamb KL; Kang X; Gu T; Shen WH; Yin Y. 2014. PTEN C-terminal deletion causes genomic instability and tumor development. Cell Rep 6(5):844-54. PubMed: 24561254 MGI: J:211716
Sung HJ; Ma W; Starost MF; Lago CU; Lim PK; Sack MN; Kang JG; Wang PY; Hwang PM. 2011. Ambient oxygen promotes tumorigenesis. PLoS One 6(5):e19785. PubMed: 21589870 MGI: J:172642
Sung YH; Kim HJ; Devkota S; Roh J; Lee J; Rhee K; Bahk YY; Lee HW. 2010. Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response. Cancer Res 70(24):10454-63. PubMed: 21159655 MGI: J:167598
Swaminathan S; Huang C; Geng H; Chen Z; Harvey R; Kang H; Ng C; Titz B; Hurtz C; Sadiyah MF; Nowak D; Thoennissen GB; Rand V; Graeber TG; Koeffler HP; Carroll WL; Willman CL; Hall AG; Igarashi K; Melnick A; Muschen M. 2013. BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nat Med 19(8):1014-22. PubMed: 23852341 MGI: J:200089
Switon K; Kotulska K; Janusz-Kaminska A; Zmorzynska J; Jaworski J. 2017. Molecular neurobiology of mTOR. Neuroscience 341:112-153. PubMed: 27889578 MGI: J:238268
Symonds H; Krall L; Remington L; Saenz-Robles M; Lowe S; Jacks T; Van Dyke T. 1994. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78(4):703-11. PubMed: 8069917 MGI: J:55471
Takahashi K; Akiyama H; Shimazaki K; Uchida C; Akiyama-Okunuki H; Tomita M; Fukumoto M; Uchida T. 2007. Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1. Oncogene 26(26):3835-45. PubMed: 17160015 MGI: J:122891
Takai H; Wang RC; Takai KK; Yang H; de Lange T. 2007. Tel2 regulates the stability of PI3K-related protein kinases. Cell 131(7):1248-59. PubMed: 18160036 MGI: J:141633
Talos F; Mena P; Fingerle-Rowson G; Moll U; Petrenko O. 2005. MIF loss impairs Myc-induced lymphomagenesis. Cell Death Differ 12(10):1319-28. PubMed: 15947793 MGI: J:101099
Talos F; Petrenko O; Mena P; Moll UM. 2005. Mitochondrially targeted p53 has tumor suppressor activities in vivo. Cancer Res 65(21):9971-81. PubMed: 16267022 MGI: J:102727
Tan EH; Morton JP; Timpson P; Tucci P; Melino G; Flores ER; Sansom OJ; Vousden KH; Muller PA. 2014. Functions of TAp63 and p53 in restraining the development of metastatic cancer. Oncogene 33(25):3325-33. PubMed: 23873029 MGI: J:212617
Tanaka S; Maekawa A; Matsubara L; Imanishi A; Yano M; Roeder RG; Hasegawa N; Asano S; Ito M. 2016. Periostin supports hematopoietic progenitor cells and niche-dependent myeloblastoma cells in vitro. Biochem Biophys Res Commun 478(4):1706-12. PubMed: 27596966 MGI: J:239007
Tashakori M; Zhang Y; Xiong S; You MJ; Lozano G. 2016. p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis. Mol Cancer Res 14(1):56-65. PubMed: 26527653 MGI: J:230519
Taverna D; Ullman-Cullere M; Rayburn H; Bronson RT; Hynes RO. 1998. A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesis. Cancer Res 58(4):848-53. PubMed: 9485045 MGI: J:45769
TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. PubMed: 12829028 MGI: J:115677
Teague JE; Ryu HY; Kirber M; Sherr DH; Schlezinger JJ. 2010. Proximal Events in 7,12-Dimethylbenz[a]anthracene-Induced, Stromal Cell-Dependent Bone Marrow B Cell Apoptosis: Stromal Cell-B Cell Communication and Apoptosis Signaling. J Immunol 185(6):3369-78. PubMed: 20720205 MGI: J:163541
Tebbs RS; Flannery ML; Meneses JJ; Hartmann A; Tucker JD; Thompson LH ; Cleaver JE ; Pedersen RA. 1999. Requirement for the Xrcc1 DNA base excision repair gene during early mouse development. Dev Biol 208(2):513-29. PubMed: 10191063 MGI: J:54226
Tedeschi A; Nguyen T; Puttagunta R; Gaub P; Di Giovanni S. 2009. A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration. Cell Death Differ 16(4):543-54. PubMed: 19057620 MGI: J:158081
Teng G; Maman Y; Resch W; Kim M; Yamane A; Qian J; Kieffer-Kwon KR; Mandal M; Ji Y; Meffre E; Clark MR; Cowell LG; Casellas R; Schatz DG. 2015. RAG Represents a Widespread Threat to the Lymphocyte Genome. Cell 162(4):751-65. PubMed: 26234156 MGI: J:224831
Terrinoni A; Pagani IS; Zucchi I; Chiaravalli AM; Serra V; Rovera F; Sirchia S; Dionigi G; Miozzo M; Frattini A; Ferrari A; Capella C; Pasquali F; Curto FL; Albertini A; Melino G; Porta G. 2011. OTX1 expression in breast cancer is regulated by p53. Oncogene 30(27):3096-103. PubMed: 21478910 MGI: J:174713
Terzian T; Dumble M; Arbab F; Thaller C; Donehower LA; Lozano G; Justice MJ; Roop DR; Box NF. 2011. Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol 224(4):540-52. PubMed: 21674502 MGI: J:174216
Terzian T; Suh YA; Iwakuma T; Post SM; Neumann M; Lang GA; Van Pelt CS; Lozano G. 2008. The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss. Genes Dev 22(10):1337-44. PubMed: 18483220 MGI: J:134767
Terzian T; Wang Y; Van Pelt CS; Box NF; Travis EL; Lozano G. 2007. Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development. Mol Cell Biol 27(15):5479-85. PubMed: 17526734 MGI: J:123661
Tetteh PW; Kretzschmar K; Begthel H; van den Born M; Korving J; Morsink F; Farin H; van Es JH; Offerhaus GJ; Clevers H. 2016. Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research. Proc Natl Acad Sci U S A 113(42):11859-11864. PubMed: 27708166 MGI: J:238627
Thanasoula M; Escandell JM; Martinez P; Badie S; Munoz P; Blasco MA; Tarsounas M. 2010. p53 Prevents entry into mitosis with uncapped telomeres. Curr Biol 20(6):521-6. PubMed: 20226664 MGI: J:158665
Theobald M; Biggs J; Hernandez J; Lustgarten J; Labadie C; Sherman LA. 1997. Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes. J Exp Med 185(5):833-41. PubMed: 9120389 MGI: J:107869
Tilli MT; Furth PA. 2003. Conditional mouse models demonstrate oncogene-dependent differences in tumor maintenance and recurrence. Breast Cancer Res 5(4):202-5. PubMed: 12817992 MGI: J:84503
Tollini LA; Jin A; Park J; Zhang Y. 2014. Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage. Cancer Cell 26(2):235-47. PubMed: 25117711 MGI: J:214218
Tomas-Loba A; Flores I; Fernandez-Marcos PJ; Cayuela ML; Maraver A; Tejera A; Borras C; Matheu A; Klatt P; Flores JM; Vina J; Serrano M; Blasco MA. 2008. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell 135(4):609-22. PubMed: 19013273 MGI: J:143075
Tomic J; Lichty B; Spaner DE. 2011. Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia. Blood 117(9):2668-80. PubMed: 21205928 MGI: J:170359
Tordella L; Koch S; Salter V; Pagotto A; Doondeea JB; Feller SM; Ratnayaka I; Zhong S; Goldin RD; Lozano G; McKeon FD; Tavassoli M; Fritzsche F; Huber GF; Rossle M; Moch H; Lu X. 2013. ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63. Proc Natl Acad Sci U S A 110(44):17969-74. PubMed: 24127607 MGI: J:201953
Tourlakis ME; Zhang S; Ball HL; Gandhi R; Liu H; Zhong J; Yuan JS; Guidos CJ; Durie PR; Rommens JM. 2015. In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency. PLoS Genet 11(6):e1005288. PubMed: 26057580 MGI: J:224762
Tsai FY; Orkin SH. 1997. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 89(10):3636-43. PubMed: 9160668 MGI: J:111591
Tsai KY; MacPherson D; Rubinson DA; Nikitin AY; Bronson R; Mercer KL; Crowley D; Jacks T. 2002. ARF mutation accelerates pituitary tumor development in Rb+/- mice. Proc Natl Acad Sci U S A 99(26):16865-70. PubMed: 12486224 MGI: J:81016
Tuveson DA; Zhu L; Gopinathan A; Willis NA; Kachatrian L; Grochow R; Pin CL; Mitin NY; Taparowsky EJ; Gimotty PA; Hruban RH; Jacks T; Konieczny SF. 2006. Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Res 66(1):242-7. PubMed: 16397237 MGI: J:105076
Uhlmann EJ; Apicelli AJ; Baldwin RL; Burke SP; Bajenaru ML; Onda H; Kwiatkowski D; Gutmann DH. 2002. Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells. Oncogene 21(25):4050-9. PubMed: 12037687 MGI: J:77179
Ulanet DB; Hanahan D. 2010. Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms. PLoS One 5(8):e12454. PubMed: 20805995 MGI: J:164020
Unnikrishnan I; Radfar A; Jenab-Wolcott J; Rosenberg N. 1999. p53 mediates apoptotic crisis in primary Abelson virus-transformed pre-B cells. Mol Cell Biol 19(7):4825-31. PubMed: 10373532 MGI: J:119895
Uziel T; Karginov FV; Xie S; Parker JS; Wang YD; Gajjar A; He L; Ellison D; Gilbertson RJ; Hannon G; Roussel MF. 2009. The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proc Natl Acad Sci U S A 106(8):2812-7. PubMed: 19196975 MGI: J:146492
Uziel T; Zindy F; Xie S; Lee Y; Forget A; Magdaleno S; Rehg JE; Calabrese C; Solecki D; Eberhart CG; Sherr SE; Plimmer S; Clifford SC; Hatten ME; McKinnon PJ; Gilbertson RJ; Curran T; Sherr CJ; Roussel MF. 2005. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev 19(22):2656-67. PubMed: 16260494 MGI: J:102702
Vaillant F; Asselin-Labat ML; Shackleton M; Forrest NC; Lindeman GJ; Visvader JE. 2008. The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res 68(19):7711-7. PubMed: 18829523 MGI: J:141826
Valente LJ; Gray DH; Michalak EM; Pinon-Hofbauer J; Egle A; Scott CL; Janic A; Strasser A. 2013. p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa. Cell Rep 3(5):1339-45. PubMed: 23665218 MGI: J:198484
Van Bodegom D; Saifudeen Z; Dipp S; Puri S; Magenheimer BS; Calvet JP; El-Dahr SS. 2006. The polycystic kidney disease-1 gene is a target for p53-mediated transcriptional repression. J Biol Chem 281(42):31234-44. PubMed: 16931520 MGI: J:117400
Van Sloun PP; Varlet I; Sonneveld E; Boei JJ; Romeijn RJ; Eeken JC; De Wind N. 2002. Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage. Mol Cell Biol 22(7):2159-69. PubMed: 11884603 MGI: J:75450
Vannier JB; Sandhu S; Petalcorin MI; Wu X; Nabi Z; Ding H; Boulton SJ. 2013. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Science 342(6155):239-42. PubMed: 24115439 MGI: J:202812
Varela I; Cadinanos J; Pendas AM; Gutierrez-Fernandez A; Folgueras AR; Sanchez LM; Zhou Z; Rodriguez FJ; Stewart CL; Vega JA; Tryggvason K; Freije JM; Lopez-Otin C. 2005. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 437(7058):564-8. PubMed: 16079796 MGI: J:134546
Vaslet CA; Messier NJ; Kane AB. 2002. Accelerated progression of asbestos-induced mesotheliomas in heterozygous p53+/- mice. Toxicol Sci 68(2):331-8. PubMed: 12151629 MGI: J:126303
Vaughn AE; Deshmukh M. 2007. Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons. Cell Death Differ 14(5):973-81. PubMed: 17218959 MGI: J:139242
Velez JM; Miriyala S; Nithipongvanitch R; Noel T; Plabplueng CD; Oberley T; Jungsuwadee P; Van Remmen H; Vore M; St Clair DK. 2011. p53 Regulates Oxidative Stress-Mediated Retrograde Signaling: A Novel Mechanism for Chemotherapy-Induced Cardiac Injury. PLoS One 6(3):e18005. PubMed: 21479164 MGI: J:171446
Venkatanarayan A; Raulji P; Norton W; Chakravarti D; Coarfa C; Su X; Sandur SK; Ramirez MS; Lee J; Kingsley CV; Sananikone EF; Rajapakshe K; Naff K; Parker-Thornburg J; Bankson JA; Tsai KY; Gunaratne PH; Flores ER. 2015. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature 517(7536):626-30. PubMed: 25409149 MGI: J:218385
Vera G; Rivera-Munoz P; Abramowski V; Malivert L; Lim A; Bole-Feysot C; Martin C; Florkin B; Latour S; Revy P; de Villartay JP. 2013. Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans. Mol Cell Biol 33(4):701-11. PubMed: 23207905 MGI: J:194422
Verschuren EW; Hodgson JG; Gray JW; Kogan S; Jones N; Evan GI. 2004. The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis. Cancer Res 64(2):581-9. PubMed: 14744772 MGI: J:88091
Vicente-Duenas C; Fontan L; Gonzalez-Herrero I; Romero-Camarero I; Segura V; Aznar MA; Alonso-Escudero E; Campos-Sanchez E; Ruiz-Roca L; Barajas-Diego M; Sagardoy A; Martinez-Ferrandis JI; Abollo-Jimenez F; Bertolo C; Penuelas I; Garcia-Criado FJ; Garcia-Cenador MB; Tousseyn T; Agirre X; Prosper F; Garcia-Bragado F; McPhail ED; Lossos IS; Du MQ; Flores T; Hernandez-Rivas JM; Gonzalez M; Salar A; Bellosillo B; Conde E; Siebert R; Sagaert X; Cobaleda C; Sanchez-Garcia I; Martinez-Climent JA. 2012. Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice. Proc Natl Acad Sci U S A 109(26):10534-9. PubMed: 22689981 MGI: J:185590
Vives V; Su J; Zhong S; Ratnayaka I; Slee E; Goldin R; Lu X. 2006. ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev 20(10):1262-7. PubMed: 16702401 MGI: J:108701
Vlangos CN; O'Connor BC; Morley MJ; Krause AS; Osawa GA; Keegan CE. 2009. Caudal regression in adrenocortical dysplasia (acd) mice is caused by telomere dysfunction with subsequent p53-dependent apoptosis. Dev Biol 334(2):418-28. PubMed: 19660449 MGI: J:153642
Vo BT; Wolf E; Kawauchi D; Gebhardt A; Rehg JE; Finkelstein D; Walz S; Murphy BL; Youn YH; Han YG; Eilers M; Roussel MF. 2016. The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity. Cancer Cell 29(1):5-16. PubMed: 26766587 MGI: J:231323
Vogel KS; Klesse LJ; Velasco-Miguel S; Meyers K; Rushing EJ; Parada LF. 1999. Mouse tumor model for neurofibromatosis type 1. Science 286(5447):2176-9. PubMed: 10591653 MGI: J:58877
Vogel KS; Parada LF. 1998. Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin. Mol Cell Neurosci 11(1-2):19-28. PubMed: 9608530 MGI: J:47680
Volk EL; Fan L; Schuster K; Rehg JE; Harris LC. 2009. The MDM2-a splice variant of MDM2 alters transformation in vitro and the tumor spectrum in both Arf- and p53-null models of tumorigenesis. Mol Cancer Res 7(6):863-9. PubMed: 19491200 MGI: J:205244
Wagner M; Greten FR; Weber CK; Koschnick S; Mattfeldt T; Deppert W; Kern H; Adler G; Schmid RM. 2001. A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. Genes Dev 15(3):286-93. PubMed: 11159909 MGI: J:67389
Walrath JC; Fox K; Truffer E; Gregory Alvord W; Quinones OA; Reilly KM. 2009. Chr 19(A/J) modifies tumor resistance in a sex- and parent-of-origin-specific manner. Mamm Genome 20(4):214-23. PubMed: 19347398 MGI: J:147432
Wang H; Chen Q; Lee SH; Choi Y; Johnson FB; Pignolo RJ. 2012. Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging. Aging Cell 11(4):704-13. PubMed: 22621437 MGI: J:214714
Wang J; Morita Y; Han B; Niemann S; Loffler B; Rudolph KL. 2016. Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing. Nat Cell Biol 18(5):480-90. PubMed: 27088856 MGI: J:236637
Wang L; Bowman L; Lu Y; Rojanasakul Y; Mercer RR; Castranova V; Ding M. 2005. Essential role of p53 in silica-induced apoptosis. Am J Physiol Lung Cell Mol Physiol 288(3):L488-96. PubMed: 15557088 MGI: J:104767
Wang L; Yang L; Debidda M; Witte D; Zheng Y. 2007. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Proc Natl Acad Sci U S A 104(4):1248-53. PubMed: 17227869 MGI: J:119516
Wang R; Dillon CP; Shi LZ; Milasta S; Carter R; Finkelstein D; McCormick LL; Fitzgerald P; Chi H; Munger J; Green DR. 2011. The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation. Immunity 35(6):871-82. PubMed: 22195744 MGI: J:179281
Wang S; Guo M; Ouyang H; Li X; Cordon-Cardo C; Kurimasa A; Chen DJ; Fuks Z; Ling CC; Li GC. 2000. The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest. Proc Natl Acad Sci U S A 97(4):1584-8. PubMed: 10677503 MGI: J:126920
Wang X; Kua HY; Hu Y; Guo K; Zeng Q; Wu Q; Ng HH; Karsenty G; de Crombrugghe B; Yeh J; Li B. 2006. p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol 172(1):115-25. PubMed: 16380437 MGI: J:104404
Wang X; Zhou YX; Qiao W; Tominaga Y; Ouchi M; Ouchi T; Deng CX. 2006. Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene 25(54):7148-58. PubMed: 16715125 MGI: J:145680
Wang Y; Cai KQ; Smith ER; Yeasky TM; Moore R; Ganjei-Azar P; Klein-Szanto AJ; Godwin AK; Hamilton TC; Xu XX. 2016. Follicle Depletion Provides a Permissive Environment for Ovarian Carcinogenesis. Mol Cell Biol 36(18):2418-30. PubMed: 27354067 MGI: J:236161
Wang Y; Klumpp S; Amin HM; Liang H; Li J; Estrov Z; Zweidler-McKay P; Brandt SJ; Agulnick A; Nagarajan L. 2010. SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability. Oncogene 29(21):3044-53. PubMed: 20348955 MGI: J:162035
Wang Y; Wang X; Flores ER; Yu J; Chang S. 2016. Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. Aging Cell 15(4):646-60. PubMed: 27113195 MGI: J:234790
Wang Y; Yang J; Zheng H; Tomasek GJ; Zhang P; McKeever PE; Lee EY; Zhu Y. 2009. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 15(6):514-26. PubMed: 19477430 MGI: J:149662
Wang Y; Zhang W; Edelmann L; Kolodner RD; Kucherlapati R; Edelmann W. 2010. Cis lethal genetic interactions attenuate and alter p53 tumorigenesis. Proc Natl Acad Sci U S A 107(12):5511-5. PubMed: 20212136 MGI: J:158687
Wang Z; He Y; Deng W; Lang L; Yang H; Jin B; Kolhe R; Ding HF; Zhang J; Hai T; Yan C. 2018. Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice. Oncogene 37(1):18-27. PubMed: 28869597 MGI: J:254261
Watkins-Chow DE; Cooke J; Pidsley R; Edwards A; Slotkin R; Leeds KE; Mullen R; Baxter LL; Campbell TG; Salzer MC; Biondini L; Gibney G; Phan Dinh Tuy F; Chelly J; Morris HD; Riegler J; Lythgoe MF; Arkell RM; Loreni F; Flint J; Pavan WJ; Keays DA. 2013. Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. PLoS Genet 9(1):e1003094. PubMed: 23382688 MGI: J:195156
Watson LA; Solomon LA; Li JR; Jiang Y; Edwards M; Shin-ya K; Beier F; Berube NG. 2013. Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest 123(5):2049-63. PubMed: 23563309 MGI: J:201463
Weber GF; Bronson RT; Ilagan J; Cantor H; Schmits R; Mak TW. 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res 62(8):2281-6. PubMed: 11956084 MGI: J:76201
Weber JD; Jeffers JR; Rehg JE; Randle DH; Lozano G; Roussel MF; Sherr CJ; Zambetti GP. 2000. p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev 14(18):2358-65. PubMed: 10995391 MGI: J:64876
Wei C; Amos CI; Stephens LC; Campos I; Deng JM; Behringer RR; Rashid A; Frazier ML. 2005. Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res 65(24):11297-303. PubMed: 16357136 MGI: J:104347
Wei G; DeFeo K; Hayes CS; Woster PM; Mandik-Nayak L; Gilmour SK. 2008. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res 68(7):2214-22. PubMed: 18381427 MGI: J:133302
Wei L; Leibowitz BJ; Wang X; Epperly M; Greenberger J; Zhang L; Yu J. 2016. Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice. J Clin Invest 126(11):4076-4087. PubMed: 27701148 MGI: J:239622
Wei Q; Dong G; Yang T; Megyesi J; Price PM; Dong Z. 2007. Activation and involvement of p53 in cisplatin-induced nephrotoxicity. Am J Physiol Renal Physiol 293(4):F1282-91. PubMed: 17670903 MGI: J:125768
Weiss WA; Israel M; Cobbs C; Holland E; James CD; Louis DN; Marks C; McClatchey AI; Roberts T; Van Dyke T; Wetmore C; Chiu IM; Giovannini M; Guha A; Higgins RJ; Marino S; Radovanovic I; Reilly K; Aldape K. 2002. Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene 21(49):7453-63. PubMed: 12386807 MGI: J:79667
Weitzman JB; Fiette L; Matsuo K; Yaniv M. 2000. JunD protects cells from p53-dependent senescence and apoptosis Mol Cell 6(5):1109-19. PubMed: 11106750 MGI: J:65879
Wendel HG; Malina A; Zhao Z; Zender L; Kogan SC; Cordon-Cardo C; Pelletier J; Lowe SW. 2006. Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo. Cancer Res 66(15):7639-46. PubMed: 16885364 MGI: J:112099
Wetmore C; Eberhart DE; Curran T. 2001. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61(2):513-6. PubMed: 11212243 MGI: J:67452
Whang YE; Tran C; Henderson C; Syljuasen RG; Rozengurt N; McBride WH; Sawyers CL. 2000. c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency. Proc Natl Acad Sci U S A 97(10):5486-91. PubMed: 10805805 MGI: J:62221
White JD; Rachel C; Vermeulen R; Davies M; Grounds MD. 2002. The role of p53 in vivo during skeletal muscle post-natal development and regeneration: studies in p53 knockout mice. Int J Dev Biol 46(4):577-82. PubMed: 12141446 MGI: J:100049
Widau RC; Zheng Y; Sung CY; Zelivianskaia A; Roach LE; Bachmeyer KM; Abramova T; Desgardin A; Rosner A; Cunningham JM; Skapek SX. 2012. p19Arf Represses Platelet-Derived Growth Factor Receptor beta by Transcriptional and Posttranscriptional Mechanisms. Mol Cell Biol 32(21):4270-82. PubMed: 22907756 MGI: J:189250
Wikonkal NM; Remenyik E; Knezevic D; Zhang W; Liu M; Zhao H; Berton TR; Johnson DG; Brash DE. 2003. Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice. Nat Cell Biol 5(7):655-60. PubMed: 12833065 MGI: J:84051
Wilhelmsson U; Eliasson C; Bjerkvig R; Pekny M. 2003. Loss of GFAP expression in high-grade astrocytomas does not contribute to tumor development or progression. Oncogene 22(22):3407-11. PubMed: 12776191 MGI: J:84194
Williams BO; Remington L; Albert DM; Mukai S; Bronson RT; Jacks T. 1994. Cooperative tumorigenic effects of germline mutations in Rb and p53. Nat Genet 7(4):480-4. PubMed: 7951317 MGI: J:19542
Williams BR; Mirzoeva OK; Morgan WF; Lin J; Dunnick W; Petrini JH. 2002. A murine model of nijmegen breakage syndrome. Curr Biol 12(8):648-53. PubMed: 11967151 MGI: J:75956
Williams TM; Lee H; Cheung MW; Cohen AW; Razani B; Iyengar P; Scherer PE; Pestell RG; Lisanti MP. 2004. Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia. J Biol Chem 279(23):24745-56. PubMed: 15044451 MGI: J:90334
Wilson AM; Morquette B; Abdouh M; Unsain N; Barker PA; Feinstein E; Bernier G; Di Polo A. 2013. ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo. J Neurosci 33(5):2205-16. PubMed: 23365256 MGI: J:194279
Wissing ER; Boyer JG; Kwong JQ; Sargent MA; Karch J; McNally EM; Otsu K; Molkentin JD. 2014. P38alpha MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism. Hum Mol Genet 23(20):5452-63. PubMed: 24876160 MGI: J:219250
Wloga EH; Criniti V; Yamasaki L; Bronson RT. 2004. Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1. Nat Cell Biol 6(7):565-7; author reply 567-8. PubMed: 15232580 MGI: J:91560
Wolvetang EJ; Wilson TJ; Sanij E; Busciglio J; Hatzistavrou T; Seth A; Hertzog PJ; Kola I. 2003. ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Hum Mol Genet 12(3):247-55. PubMed: 12554679 MGI: J:81680
Wong KS; Li YJ; Howard J; Ben-David Y. 1999. Loss of p53 in F-MuLV induced-erythroleukemias accelerates the acquisition of mutational events that confers immortality and growth factor independence. Oncogene 18(40):5525-34. PubMed: 10523829 MGI: J:58012
Woodward J; Taylor GC; Soares DC; Boyle S; Sie D; Read D; Chathoth K; Vukovic M; Tarrats N; Jamieson D; Campbell KJ; Blyth K; Acosta JC; Ylstra B; Arends MJ; Kranc KR; Jackson AP; Bickmore WA; Wood AJ. 2016. Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability. Genes Dev :. PubMed: 27737961 MGI: J:236233
Wu B; Qiu W; Wang P; Yu H; Cheng T; Zambetti GP; Zhang L; Yu J. 2007. p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut 56(5):645-54. PubMed: 17127703 MGI: J:135945
Wu J; Trogadis J; Bremner R. 2001. Rod and cone degeneration in the rd mouse is p53 independent. Mol Vis 7:101-6. PubMed: 11344337 MGI: J:126023
Wu L; Multani AS; He H; Cosme-Blanco W; Deng Y; Deng JM; Bachilo O; Pathak S; Tahara H; Bailey SM; Deng Y; Behringer RR; Chang S. 2006. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 126(1):49-62. PubMed: 16839876 MGI: J:112184
Wu X; Northcott PA; Dubuc A; Dupuy AJ; Shih DJ; Witt H; Croul S; Bouffet E; Fults DW; Eberhart CG; Garzia L; Van Meter T; Zagzag D; Jabado N; Schwartzentruber J; Majewski J; Scheetz TE; Pfister SM; Korshunov A; Li XN; Scherer SW; Cho YJ; Akagi K; MacDonald TJ; Koster J; McCabe MG; Sarver AL; Collins VP; Weiss WA; Largaespada DA; Collier LS; Taylor MD. 2012. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 482(7386):529-33. PubMed: 22343890 MGI: J:181542
Wu X; Sandhu S; Patel N; Triggs-Raine B; Ding H. 2010. EMG1 is essential for mouse pre-implantation embryo development. BMC Dev Biol 10:99. PubMed: 20858271 MGI: J:165972
Wylie A; Jones AE; D'Brot A; Lu WJ; Kurtz P; Moran JV; Rakheja D; Chen KS; Hammer RE; Comerford SA; Amatruda JF; Abrams JM. 2016. p53 genes function to restrain mobile elements. Genes Dev 30(1):64-77. PubMed: 26701264 MGI: J:227689
Xiao A; Wu H; Pandolfi PP; Louis DN; Van Dyke T. 2002. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell 1(2):157-68. PubMed: 12086874 MGI: J:77132
Xing D; Orsulic S. 2006. A mouse model for the molecular characterization of brca1-associated ovarian carcinoma. Cancer Res 66(18):8949-53. PubMed: 16982732 MGI: J:112932
Xiong S; Pant V; Suh YA; Van Pelt CS; Wang Y; Valentin-Vega YA; Post SM; Lozano G. 2010. Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4. Cancer Res 70(18):7148-54. PubMed: 20736370 MGI: J:164225
Xiong S; Pant V; Zhang Y; Aryal NK; You MJ; Kusewitt D; Lozano G. 2017. The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis. J Pathol 241(4):501-510. PubMed: 27925213 MGI: J:241797
Xiong S; Tu H; Kollareddy M; Pant V; Li Q; Zhang Y; Jackson JG; Suh YA; Elizondo-Fraire AC; Yang P; Chau G; Tashakori M; Wasylishen AR; Ju Z; Solomon H; Rotter V; Liu B; El-Naggar AK; Donehower LA; Martinez LA; Lozano G. 2014. Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proc Natl Acad Sci U S A 111(30):11145-50. PubMed: 25024203 MGI: J:212246
Xiong S; Van Pelt CS; Elizondo-Fraire AC; Fernandez-Garcia B; Lozano G. 2007. Loss of Mdm4 results in p53-dependent dilated cardiomyopathy. Circulation 115(23):2925-30. PubMed: 17533180 MGI: J:137114
Xiong X; Zhao Y; Tang F; Wei D; Thomas D; Wang X; Liu Y; Zheng P; Sun Y. 2014. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. Elife 3:e02236. PubMed: 25144937 MGI: J:223276
Xu E; Zhang J; Chen X. 2013. MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability. Oncogene 32(17):2169-78. PubMed: 22710720 MGI: J:198026
Xu H; Menendez S; Schlegelberger B; Bae N; Aplan PD; Gohring G; Deblasio TR; Nimer SD. 2012. Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13-driven mouse model. Blood 120(15):3089-97. PubMed: 22927245 MGI: J:192937
Xu M; Yu Q; Subrahmanyam R; Difilippantonio MJ; Ried T; Sen JM. 2008. Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo. Mol Cell Biol 28(5):1713-23. PubMed: 18160717 MGI: J:132650
Xu Y; Yang EM; Brugarolas J; Jacks T; Baltimore D. 1998. Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice. Mol Cell Biol 18(7):4385-90. PubMed: 9632822 MGI: J:49262
Xu Z; Sharp PP; Yao Y; Segal D; Ang CH; Khaw SL; Aubrey BJ; Gong J; Kelly GL; Herold MJ; Strasser A; Roberts AW; Alexander WS; Burns CJ; Huang DC; Glaser SP. 2016. BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells. Leukemia 30(7):1531-41. PubMed: 27055867 MGI: J:232796
Yahagi N; Shimano H; Matsuzaka T; Najima Y; Sekiya M; Nakagawa Y; Ide T; Tomita S; Okazaki H; Tamura Y; Iizuka Y; Ohashi K; Gotoda T; Nagai R; Kimura S; Ishibashi S; Osuga J; Yamada N. 2003. p53 Activation in adipocytes of obese mice. J Biol Chem 278(28):25395-400. PubMed: 12734185 MGI: J:120652
Yahagi N; Shimano H; Matsuzaka T; Sekiya M; Najima Y; Okazaki S; Okazaki H; Tamura Y; Iizuka Y; Inoue N; Nakagawa Y; Takeuchi Y; Ohashi K; Harada K; Gotoda T; Nagai R; Kadowaki T; Ishibashi S; Osuga J; Yamada N. 2004. p53 involvement in the pathogenesis of fatty liver disease. J Biol Chem 279(20):20571-5. PubMed: 14985341 MGI: J:124263
Yallowitz AR; Li D; Lobko A; Mott D; Nemajerova A; Marchenko N. 2015. Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promote Mammary Tumorigenesis. Mol Cancer Res 13(4):743-54. PubMed: 25573952 MGI: J:220187
Yamanishi Y; Boyle DL; Pinkoski MJ; Mahboubi A; Lin T; Han Z; Zvaifler NJ; Green DR; Firestein GS. 2002. Regulation of Joint Destruction and Inflammation by p53 in Collagen-Induced Arthritis. Am J Pathol 160(1):123-30. PubMed: 11786406 MGI: J:73730
Yan CT; Boboila C; Souza EK; Franco S; Hickernell TR; Murphy M; Gumaste S; Geyer M; Zarrin AA; Manis JP; Rajewsky K; Alt FW. 2007. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449(7161):478-82. PubMed: 17713479 MGI: J:126758
Yan H; Blackburn AC; McLary SC; Tao L; Roberts AL; Xavier EA; Dickinson ES; Seo JH; Arenas RB; Otis CN; Cao QJ; Lawlor RG; Osborne BA; Kittrell FS; Medina D; Jerry DJ. 2010. Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice. Am J Pathol 176(3):1421-32. PubMed: 20110418 MGI: J:158515
Yan J; Di Y; Shi H; Rao H; Huo K. 2010. Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination. FEBS Lett 584(20):4319-24. PubMed: 20849854 MGI: J:165421
Yan W; Scoumanne A; Jung YS; Xu E; Zhang J; Zhang Y; Ren C; Sun P; Chen X. 2016. Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation. Genes Dev 30(5):522-34. PubMed: 26915821 MGI: J:231514
Yang A; Reeves RH. 2011. Increased Survival following Tumorigenesis in Ts65Dn Mice That Model Down Syndrome. Cancer Res 71(10):3573-81. PubMed: 21467166 MGI: J:171978
Yang DH; Fazili Z; Smith ER; Cai KQ; Klein-Szanto A; Cohen C; Horowitz IR; Xu XX. 2006. Disabled-2 Heterozygous Mice Are Predisposed to Endometrial and Ovarian Tumorigenesis and Exhibit Sex-Biased Embryonic Lethality in a p53-Null Background. Am J Pathol 169(1):258-67. PubMed: 16816378 MGI: J:110173
Yang X; Klein R; Tian X; Cheng HT; Kopan R; Shen J. 2004. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol 269(1):81-94. PubMed: 15081359 MGI: J:90392
Yao R; Natsume Y; Saiki Y; Shioya H; Takeuchi K; Yamori T; Toki H; Aoki I; Saga T; Noda T. 2012. Disruption of Tacc3 function leads to in vivo tumor regression. Oncogene 31(2):135-48. PubMed: 21685933 MGI: J:179414
Yazinski SA; Westcott PM; Ong K; Pinkas J; Peters RM; Weiss RS. 2009. Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration. Proc Natl Acad Sci U S A 106(50):21282-7. PubMed: 19918068 MGI: J:155573
Yeh JR; Ju R; Brdlik CM; Zhang W; Zhang Y; Matyskiela ME; Shotwell JD; Crews CM. 2006. Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A 103(27):10379-84. PubMed: 16790550 MGI: J:111701
Yi W; Hu X; Chen Z; Liu L; Tian Y; Chen H; Cong YS; Yang F; Zhang L; Rudolph KL; Zhang Z; Zhao Y; Ju Z. 2015. Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner. Blood 126(5):620-8. PubMed: 26012568 MGI: J:225921
Yin C; Knudson CM; Korsmeyer SJ; Van Dyke T. 1997. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385(6617):637-40. PubMed: 9024662 MGI: J:38331
Yin Y; Stahl BC; DeWolf WC; Morgentaler A. 1998. p53-mediated germ cell quality control in spermatogenesis. Dev Biol 204(1):165-71. PubMed: 9851850 MGI: J:110639
Yin Y; Stahl BC; DeWolf WC; Morgentaler A. 2002. P53 and Fas are sequential mechanisms of testicular germ cell apoptosis. J Androl 23(1):64-70. PubMed: 11780924 MGI: J:105850
Yin Z; Menendez D; Resnick MA; French JE; Janardhan KS; Jetten AM. 2012. RAP80 is critical in maintaining genomic stability and suppressing tumor development. Cancer Res 72(19):5080-90. PubMed: 22896338 MGI: J:191827
Young LC; Keuling AM; Lai R; Nation PN; Tron VA; Andrew SE. 2007. The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis. Carcinogenesis 28(10):2131-8. PubMed: 17615258 MGI: J:125800
Yu WN; Nogueira V; Sobhakumari A; Patra KC; Bhaskar PT; Hay N. 2015. Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. Cell Rep 12(4):610-21. PubMed: 26190111 MGI: J:232525
Yuan L; Liu JG; Hoja MR; Lightfoot DA; Hoog C. 2001. The checkpoint monitoring chromosomal pairing in male meiotic cells is p53-independent. Cell Death Differ 8(3):316-7. PubMed: 11319615 MGI: J:105790
Zan H; Tat C; Qiu Z; Taylor JR; Guerrero JA; Shen T; Casali P. 2017. Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination. Nat Commun 8(None):14244. PubMed: 28176781 MGI: J:244154
Zeini M; Traves PG; Lopez-Fontal R; Pantoja C; Matheu A; Serrano M; Bosca L; Hortelano S. 2006. Specific contribution of p19(ARF) to nitric oxide-dependent apoptosis. J Immunol 177(5):3327-36. PubMed: 16920973 MGI: J:139500
Zelazny E; Li B; Anagnostopoulos AM; Coleman A; Perkins AS. 2001. Cooperating Oncogenic Events in Murine Mammary Tumorigenesis: Assessment of ErbB2, Mutant p53, and Mouse Mammary Tumor Virus. Exp Mol Pathol 70(3):183-93. PubMed: 11417997 MGI: J:70644
Zeng Q; Oakley B. 1999. p53 and Bax: putative death factors in taste cell turnover. J Comp Neurol 413(1):168-80. PubMed: 10464378 MGI: J:57477
Zhang C; Liu J; Liang Y; Wu R; Zhao Y; Hong X; Lin M; Yu H; Liu L; Levine AJ; Hu W; Feng Z. 2013. Tumour-associated mutant p53 drives the Warburg effect. Nat Commun 4:2935. PubMed: 24343302 MGI: J:226220
Zhang G; Xie Y; Zhou Y; Xiang C; Chen L; Zhang C; Hou X; Chen J; Zong H; Liu G. 2017. p53 pathway is involved in cell competition during mouse embryogenesis. Proc Natl Acad Sci U S A 114(3):498-503. PubMed: 28049824 MGI: J:239540
Zhang J; Cho SJ; Shu L; Yan W; Guerrero T; Kent M; Skorupski K; Chen H; Chen X. 2011. Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas. Genes Dev 25(14):1528-43. PubMed: 21764855 MGI: J:174192
Zhang J; Schweers B; Dyer MA. 2004. The first knockout mouse model of retinoblastoma. Cell Cycle 3(7):952-9. PubMed: 15190215 MGI: J:103618
Zhang J; Xu E; Ren C; Yan W; Zhang M; Chen M; Cardiff RD; Imai DM; Wisner E; Chen X. 2014. Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A 111(52):18637-42. PubMed: 25512531 MGI: J:216929
Zhang L; Anglesio MS; O'sullivan M; Zhang F; Yang G; Sarao R; Nghiem MP; Cronin S; Hara H; Melnyk N; Li L; Wada T; Liu PP; Farrar J; Arceci RJ; Sorensen PH; Penninger JM. 2007. The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med 13(9):1060-1069. PubMed: 17694067 MGI: J:125183
Zhang L; Reynolds TL; Shan X; Desiderio S. 2011. Coupling of v(d)j recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis. Immunity 34(2):163-74. PubMed: 21349429 MGI: J:168974
Zhang M; Behbod F; Atkinson RL; Landis MD; Kittrell F; Edwards D; Medina D; Tsimelzon A; Hilsenbeck S; Green JE; Michalowska AM; Rosen JM. 2008. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res 68(12):4674-82. PubMed: 18559513 MGI: J:138898
Zhang Q; He X; Chen L; Zhang C; Gao X; Yang Z; Liu G. 2012. Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development. J Pathol 228(3):416-28. PubMed: 22821713 MGI: J:188490
Zhang S; Zheng M; Kibe R; Huang Y; Marrero L; Warren S; Zieske AW; Iwakuma T; Kolls JK; Cui Y. 2011. Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis. FASEB J 25(7):2387-98. PubMed: 21471252 MGI: J:174321
Zhang X; Podsypanina K; Huang S; Mohsin SK; Chamness GC; Hatsell S; Cowin P; Schiff R; Li Y. 2005. Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations. Oncogene 24(26):4220-31. PubMed: 15824740 MGI: J:99546
Zhang Y; Qian Y; Zhang J; Yan W; Jung YS; Chen M; Huang E; Lloyd K; Duan Y; Wang J; Liu G; Chen X. 2017. Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2. Genes Dev None(None):None. PubMed: 28747430 MGI: J:244082
Zhao F; Obermann S; von Wasielewski R; Haile L; Manns MP; Korangy F; Greten TF. 2009. Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma. Immunology 128(1):141-9. PubMed: 19689743 MGI: J:162293
Zheng S; El-Naggar AK; Kim ES; Kurie JM; Lozano G. 2007. A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene 26(48):6896-904. PubMed: 17486075 MGI: J:129627
Zhou S; Gu L; He J; Zhang H; Zhou M. 2011. MDM2 Regulates Vascular Endothelial Growth Factor mRNA Stabilization in Hypoxia. Mol Cell Biol 31(24):4928-37. PubMed: 21986500 MGI: J:178311
Zhu F; Dolle ME; Berton TR; Kuiper RV; Capps C; Espejo A; McArthur MJ; Bedford MT; van Steeg H; de Vries A; Johnson DG. 2010. Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res 70(14):5851-9. PubMed: 20587514 MGI: J:162466
Zhu M; Weiss RS. 2007. Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells. Mol Biol Cell 18(3):1044-55. PubMed: 17215515 MGI: J:123894
Zhu Y; Guignard F; Zhao D; Liu L; Burns DK; Mason RP; Messing A; Parada LF. 2005. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8(2):119-30. PubMed: 16098465 MGI: J:101868
Zhuang J; Kamp WM; Li J; Liu C; Kang JG; Wang PY; Hwang PM. 2016. Forkhead Box O3A (FOXO3) and the Mitochondrial Disulfide Relay Carrier (CHCHD4) Regulate p53 Protein Nuclear Activity in Response to Exercise. J Biol Chem 291(48):24819-24827. PubMed: 27687729 MGI: J:237639
Zhuang J; Wang PY; Huang X; Chen X; Kang JG; Hwang PM. 2013. Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. Proc Natl Acad Sci U S A 110(43):17356-61. PubMed: 24101517 MGI: J:201969
Zindy F; Lee Y; Kawauchi D; Ayrault O; Merzoug LB; Li Y; McKinnon PJ; Roussel MF. 2015. Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation. PLoS One 10(6):e0129642. PubMed: 26091048 MGI: J:237792
Zindy F; Nilsson LM; Nguyen L; Meunier C; Smeyne RJ; Rehg JE; Eberhart C; Sherr CJ; Roussel MF. 2003. Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice. Cancer Res 63(17):5420-7. PubMed: 14500377 MGI: J:85515
Zou Q; Jin J; Hu H; Li HS; Romano S; Xiao Y; Nakaya M; Zhou X; Cheng X; Yang P; Lozano G; Zhu C; Watowich SS; Ullrich SE; Sun SC. 2014. USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol 15(6):562-70. PubMed: 24777531 MGI: J:259597
Zou X; Cong F; Coutts M; Cattoretti G; Goff SP; Calame K. 2000. p53 deficiency increases transformation by v-Abl and rescues the ability of a C-terminally truncated v-Abl mutant To induce pre-B lymphoma In vivo Mol Cell Biol 20(2):628-33. PubMed: 10611241 MGI: J:59574
Zou Y; Niu W; Qin S; Downes M; Burns DK; Zhang CL. 2012. The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche. Mol Cell Biol 32(23):4811-20. PubMed: 23028043 MGI: J:192734
Zwaferink H; Stockinger S; Reipert S; Decker T. 2008. Stimulation of inducible nitric oxide synthase expression by beta interferon increases necrotic death of macrophages upon Listeria monocytogenes infection. Infect Immun 76(4):1649-56. PubMed: 18268032 MGI: J:133523
Zwolinska AK; Heagle Whiting A; Beekman C; Sedivy JM; Marine JC. 2012. Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency. Oncogene 31(28):3311-21. PubMed: 22081066 MGI: J:186119
de Stanchina E; McCurrach ME; Zindy F; Shieh SY; Ferbeyre G; Samuelson AV; Prives C; Roussel MF; Sherr CJ; Lowe SW. 1998. E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev 12(15):2434-42. PubMed: 9694807 MGI: J:115135
ter Brugge PJ; Ta VB; de Bruijn MJ; Keijzers G; Maas A; van Gent DC; Hendriks RW. 2009. A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood 114(1):119-27. PubMed: 19332766 MGI: J:150315
van Kesteren PC; Beems RB; Luijten M; Robinson J; de Vries A; van Steeg H. 2009. DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance? Carcinogenesis 30(3):538-43. PubMed: 19136475 MGI: J:146183
van Kesteren PC; Zwart PE; Pennings JL; Gottschalk WH; Kleinjans JC; van Delft JH; van Steeg H; Luijten M. 2011. Deregulation of Cancer-Related Pathways in Primary Hepatocytes Derived from DNA Repair-Deficient Xpa-/-p53+/- Mice upon Exposure to Benzo[a]pyrene. Toxicol Sci 123(1):123-32. PubMed: 21715664 MGI: J:175079
van Kranen HJ; Westerman A; Berg RJ; Kram N; van Kreijl CF; Wester PW; de Gruijl FR. 2005. Dose-dependent effects of UVB-induced skin carcinogenesis in hairless p53 knockout mice. Mutat Res 571(1-2):81-90. PubMed: 15748640 MGI: J:96767
van Kreijl CF; McAnulty PA; Beems RB; Vynckier A; van Steeg H; Fransson-Steen R; Alden CL; Forster R; van der Laan JW; Vandenberghe J. 2001. Xpa and Xpa/p53+/- knockout mice: overview of available data. Toxicol Pathol 29 Suppl:117-27. PubMed: 11695547 MGI: J:73024
van Oers JM; Edwards Y; Chahwan R; Zhang W; Smith C; Pechuan X; Schaetzlein S; Jin B; Wang Y; Bergman A; Scharff MD; Edelmann W. 2014. The MutSbeta complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair. Oncogene 33(30):3939-46. PubMed: 24013230 MGI: J:213045
van Oostrom CT; Boeve M; van Den Berg J; de Vries A; Dolle ME; Beems RB; van Kreijl CF; Vijg J; van Steeg H. 1999. Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice. Environ Mol Mutagen 34(2-3):124-30. PubMed: 10529736 MGI: J:59517
van de Wetering CI; Knudson CM. 2007. Chromosomal instability and supernumerary centrosomes represent precursor defects in a mouse model of T-cell lymphoma. Cancer Res 67(17):8081-8. PubMed: 17804719 MGI: J:124884
van der Pluijm I; Garinis GA; Brandt RM; Gorgels TG; Wijnhoven SW; Diderich KE; de Wit J; Mitchell JR; van Oostrom C; Beems R; Niedernhofer LJ; Velasco S; Friedberg EC; Tanaka K; van Steeg H; Hoeijmakers JH; van der Horst GT. 2006. Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol 5(1):e2. PubMed: 17326724 MGI: J:122013
. 2016. Recurrent MET fusion genes represent a drug target in pediatric glioblastoma. Nat Med 22(11):1314-1320. PubMed: 27748748 MGI: J:240751

Also Known As: p53 KO

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

Trp53tm1Tyj

Allele Symbol: Trp53tm1Tyj

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Trp53tm1Tyj related

Mammalian Phenotype Terms by Genotype

Genotype: Trp53tm1Tyj/Trp53tm1TyjB6.129S2-Trp53tm1Tyj/J

cardiovascular system phenotype

vision/eye phenotype

nervous system phenotype

Genotype: Trp53tm1Tyj/Trp53+involves: 129S2/SvPas * BALB/cJ * C57BL/6

neoplasm

Genotype: Trp53tm1Tyj/Trp53+involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

mortality/aging

Genotype: Trp53tm1Tyj/Trp53+involves: 129S2/SvPas * C57BL/6 * CBA

cellular phenotype

endocrine/exocrine gland phenotype

hematopoietic system phenotype

immune system phenotype

mortality/aging

Genotype: Trp53tm1Tyj/Trp53+involves: 129S2/SvPas * C57BL/6

mortality/aging

endocrine/exocrine gland phenotype

integument phenotype

neoplasm

digestive/alimentary phenotype

muscle phenotype

respiratory system phenotype

skeleton phenotype

Genotype: Trp53tm1Tyj/Trp53+involves: 129S2/SvPas

renal/urinary system phenotype

mortality/aging

neoplasm

cellular phenotype

hematopoietic system phenotype

immune system phenotype

homeostasis/metabolism phenotype

endocrine/exocrine gland phenotype

Genotype: Trp53tm1Tyj/Trp53+involves: 129S2/SvPas * C57BL/6 * FVB/N

mortality/aging

Genotype: Trp53tm1Tyj/Trp53tm1Tyj129-Trp53tm1Tyj/J

cardiovascular system phenotype

vision/eye phenotype

Genotype: Trp53tm1Tyj/Trp53tm1Tyjinvolves: 129S2/SvPas * FVB/N

cellular phenotype

integument phenotype

Genotype: Trp53tm1Tyj/Trp53tm1Tyjinvolves: 129S2/SvPas * C57BL/6 * FVB/N

mortality/aging

homeostasis/metabolism phenotype

Genotype: Trp53tm1Tyj/Trp53tm1Tyjinvolves: 129S2/SvPas * C57BL/6 * CBA

cellular phenotype

endocrine/exocrine gland phenotype

hematopoietic system phenotype

immune system phenotype

mortality/aging

Genotype: Trp53tm1Tyj/Trp53tm1Tyjinvolves: 129S2/SvPas * BALB/c

cellular phenotype

Genotype: Trp53tm1Tyj/Trp53tm1Tyjinvolves: 129S2/SvPas * C57BL/6

endocrine/exocrine gland phenotype

skeleton phenotype

muscle phenotype

mortality/aging

neoplasm

cellular phenotype

digestive/alimentary phenotype

Genotype: Trp53tm1Tyj/Trp53tm1Tyjinvolves: 129S2/SvPas

mortality/aging

nervous system phenotype

neoplasm

Trp53^tm1Tyj

Allele Symbol: Trp53^tm1Tyj

Genotype: Trp53^tm1Tyj related

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
B6.129S2-Trp53^tm1Tyj/J

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas * BALB/cJ * C57BL/6

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas * C57BL/6 * CBA

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas * C57BL/6

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas

Genotype: Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas * C57BL/6 * FVB/N

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
129-Trp53^tm1Tyj/J

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas * FVB/N

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas * C57BL/6 * FVB/N

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas * C57BL/6 * CBA

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas * BALB/c

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas * C57BL/6

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
involves: 129S2/SvPas

Genotype: Trp53^tm1Tyj/Trp53^tm1Tyj
129S6.129-Trp53^tm1Tyj Rb1^tm1.1Jyjw

Additional - Trp53^tm1Tyj related