JAX Mouse Strain Datasheet - 002020

C57BL/6J-Apc^Min/J

Stock No:: 002020 |; multiple intestinal neoplasia

Available Now

Overview

JAXTag^TM

Also Known As: Min, multiple intestinal neoplasia

Heterozygotes of this strain develop anemia and are highly susceptible to spontaneous intestinal adenoma formation. Homozygous C57BL/6J-Apc^Min/J mice are not viable. The increased incidence of colorectal adenomas renders these mice a useful model of colon cancer. A small number of C57BL/6J-Apc^Min heterozygous female mice develop mammary tumors.

Donating Investigator

Dr. Alexandra Shedlovsky, University of Wisconsin , Madison

Dr. William F. Dove, University of Wisconsin- Madison

Genetic overview

Genetic Background	Generation
	N79pN14 (05-AUG-14)

Apc^Min

Allele Type	Gene Symbol	Gene Name
Chemically induced (ENU)	Apc	adenomatosis polyposis coli

View Genetics

Research Applications

Cancer Research

View All Research Applications

Base Price

Starting at:

$304.40 Domestic price for female 4-week

View Price List

Details

Detailed Description

The C57BL/6J-Apc^Min/J strain is highly susceptible to spontaneous intestinal adenoma formation. Homozygous mice are not viable. It was initially reported that one hundred percent of the C57BL/6J-Apc^Min heterozygous mice raised on a high fat diet develop in excess of 30 adenomas throughout the intestinal tract and most die by 120 days of age. Heterozygotes also develop anemia. (Moser et al., 1990, Su et al., 1992). A small number of C57BL/6J-Apc^Min heterozygous female mice develop mammary tumors. A subsequent publication indicates that this strain may carry a dominant modifier (Mom2) gene that reduces the number and incidence of polyp formation in C57BL/6J-Apc^Min heterozygous mice (Silverman et al., 2002).

This strain ships with a JAXTag^TM affixed. Learn more about JAXTag^TM.

Development

Following N-ethyl-N-nitrosourea (ENU) treatments to induce mutations in founder C57BL/6J mice, a forward genetic screen identified a AKR/JxB6 F1 female displaying circling behavior. This female was mated to C57BL/6J males. Some progeny from this backcross developed adult onset anemia and multiple intestinal neoplasia (Min). A tumor suppressor gene, Apc (adenomatosis polyposis coli), mutations of which have been identified in colorectal cancers and familial adenomatous polyposis (FAP), was found to cosegregate with the Min phenotype. Sequencing of Apc identified a T to A transversion of nucleotide 2549 resulting in a Leucine to a Stop codon nonsense mutation. The circling behavior was determined to be a separate heritable trait and was eliminated through subsequent crosses to C57BL/6J. These Apc^Min mice maintained on a C57BL/6J background when they were sent to The Jackson Laboratory in 1992.

Control Suggestions

Wild-type from the colony
000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Moser AR; Pitot HC; Dove WF. 1990. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247(4940):322-4. PubMed: 2296722 MGI: J:10209
Su LK; Kinzler KW; Vogelstein B; Preisinger AC; Moser AR; Luongo C; Gould KA; Dove WF. 1992. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene [published erratum appears in Science 1992 May 22;256(5060):1114] Science 256(5057):668-70. PubMed: 1350108 MGI: J:830

View All References

Genetics

Apc^Min

Allele Symbol: Apc^Min

Allele Name	multiple intestinal neoplasia
Allele Type	Chemically induced (ENU)
Allele Synonym(s)	Apc^Δ850; Apc^-; Apc^delta850; Min; Min-
Gene Symbol and Name	Apc, adenomatosis polyposis coli
Gene Synonym(s)	AI047805; AU020952; AW124434; BTPS2; CC1; DP2; DP2.5; DP3; GS; Min; Min; PPP1R46; RATAPC; expressed sequence AI047805; expressed sequence AU020952; expressed sequence AW124434; multiple intestinal neoplasia
Strain of Origin	C57BL/6J
Chromosome	18
Molecular Note	A transversion point mutation that alters nucleotide 2549 from a T to an A. This converts codon 850 from one encoding a leucine to a stop codon, truncating the expected polypeptide.
Mutations Made By	Dr. William Dove, University of Wisconsin- Madison

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Apc^Min related

Cancer Research
- Increased Tumor Incidence
  - Adenomas
  - Adenomas: intestinal adenomas
  - Mammary Gland Tumors
  - Other Tissues/Organs
  - Other Tissues/Organs: GI tract (stomach, intestine, colon)

Mammalian Phenotype Terms by Genotype

Genotype: Apc^Min/Apc⁺
B6(AKR)-Apc^Min

digestive/alimentary phenotype

increased intestinal adenocarcinoma incidence
- in N4-N8 backcross mice tumors are presesnt throughout the small and large intestines
- localization of tumors in the small and large intestines varies among mice

increased intestinal adenoma incidence

mortality/aging

premature death
- Background Sensitivity - average life-span has not decreased after N6 of backcrossing, suggesting genetic background influences effects of the mutation
- mutant mice do not a have a normal life-span, most rarely survive longer than 120 days of age

neoplasm

increased intestinal adenocarcinoma incidence
- in N4-N8 backcross mice tumors are presesnt throughout the small and large intestines
- localization of tumors in the small and large intestines varies among mice

increased intestinal adenoma incidence

increased mammary gland tumor incidence
- on this background colony maintenance data show that mammary tumors occasionally develop in heterozygous females but not in wild-type female siblings

reproductive system phenotype

abnormal pregnancy
- females are rarely able to maintain a pregnancy due to compromised health

hematopoietic system phenotype

anemia
- anemia is diagnosed by 60 days of age
- follows development of multiple adenomas which bleed into the intestinal lumen

endocrine/exocrine gland phenotype

increased mammary gland tumor incidence
- on this background colony maintenance data show that mammary tumors occasionally develop in heterozygous females but not in wild-type female siblings

mammary gland hyperplasia
- females of this genotype have an increased susceptibility to developing mammary neoplasia

integument phenotype

increased mammary gland tumor incidence
- on this background colony maintenance data show that mammary tumors occasionally develop in heterozygous females but not in wild-type female siblings

mammary gland hyperplasia
- females of this genotype have an increased susceptibility to developing mammary neoplasia

Genotype: Apc^Min/Apc⁺
C57BL/6J-Apc^Min

mortality/aging

premature death
- Background Sensitivity - life span is reduced compared to mice on an (MA/MyJ x C57BL/6J-Apc)F1 or (AKR/J x C57BL/6J-Apc)F1 background
- average lifespan is 118 +/- 26 days

neoplasm

increased colonic adenoma incidence
- tubular adenomas in the colon

increased intestinal adenoma incidence
- at 8 and 15 weeks of age, females have proportionally more small adenomas and fewer medium-sized adenomas than males
- develop adenomatous polyps with moderate dysplasia, mild nuclear atypia and frequent mitotic figures throughout the duodenal-to-colonic axis
- mean diameter of adenomas and adenoma burden increases significantly between weeks 5 and 8 and between weeks 8 and 15
- mice fed a beef or inulin diet develop a similar number of adenomas as mice fed the rodent chow diet
- most mutants exhibit a few small or medium-sized adenomas at 5 weeks of age, with numbers increasing significantly between 5 and 8 weeks and then staying at the same level thereafter
- serotonergic cells were found in 18 of 18 adenomas
- tubular adenomas in the intestine

digestive/alimentary phenotype

increased intestinal adenoma incidence
- at 8 and 15 weeks of age, females have proportionally more small adenomas and fewer medium-sized adenomas than males
- develop adenomatous polyps with moderate dysplasia, mild nuclear atypia and frequent mitotic figures throughout the duodenal-to-colonic axis
- mean diameter of adenomas and adenoma burden increases significantly between weeks 5 and 8 and between weeks 8 and 15
- mice fed a beef or inulin diet develop a similar number of adenomas as mice fed the rodent chow diet
- most mutants exhibit a few small or medium-sized adenomas at 5 weeks of age, with numbers increasing significantly between 5 and 8 weeks and then staying at the same level thereafter
- serotonergic cells were found in 18 of 18 adenomas
- tubular adenomas in the intestine

homeostasis/metabolism phenotype

increased circulating free fatty acid level
- females exhibit increased free fatty acid levels at 15 weeks of age

increased circulating triglyceride level
- females show increased triglyceride levels at 15 weeks of age

increased prostaglandin level
- increase in luminal prostaglandin E2 at 15 weeks of age

liver/biliary system phenotype

hepatic steatosis
- centrilobular-restricted steatosis is seen in the livers of mutants at 15 weeks of age

growth/size/body region phenotype

postnatal growth retardation
- regular chow-fed males stop gaining weight, lose more weight, and are smaller at 15 weeks than beef-fed males

hematopoietic system phenotype

decreased macrophage cell number
- fewer Mac-1+ (macrophages) cells in ileal mucosa at 5 weeks of age, however numbers are normal at later time points and in all dietary treatments
- however, luminal IgA, IL-12, and TNF-alpha concentrations are normal

immune system phenotype

decreased macrophage cell number
- fewer Mac-1+ (macrophages) cells in ileal mucosa at 5 weeks of age, however numbers are normal at later time points and in all dietary treatments
- however, luminal IgA, IL-12, and TNF-alpha concentrations are normal

Genotype: Apc^Min/Apc⁺
involves: C57BL/6J

integument phenotype

increased mammary adenocarcinoma incidence
- 12% of heterozygotes developed mammary adenocanthomas

mortality/aging

premature death
- heterozygotes begin to die at 7 months of age
- mice become moribound and die from anemia and intestinal obstruction by 160-180 days of age

neoplasm

increased intestinal adenoma incidence
- mice develop intestinal adenomas and colorectal adenomas by 160-180 days of age
- small and large adenomas are seen throughout the intestine with more lesions found in the ileum compared to Apc^tm1Cip heterozygotes

increased mammary adenocarcinoma incidence
- 12% of heterozygotes developed mammary adenocanthomas

digestive/alimentary phenotype

abnormal enterocyte proliferation
- however, 17beta-estradiol replacement increases colonocyte proliferation 2-fold
- reduced proliferation of cells in the colon in ovariectomized

abnormal intestinal goblet cell morphology
- fewer mature goblet cells in the colon with prevelant pregoblet cells in ovariectomized mcie treated with 17beta-estradiol
- the goblet cell ratio in ovariectomized mice is increased compared to in intact mice

abnormal intestinal mucosa morphology
- ovariectomized mice exhibit abnormal submucosal with thickening of the muscularis mucosae and enrichment of stromal components compared with control mice

abnormal large intestine crypts of Lieberkuhn morphology
- ovariectomized mice exhibit reduced crypt length and distortion of surface epithelial cells in the colon compared with control mice

increased intestinal adenoma incidence
- mice develop intestinal adenomas and colorectal adenomas by 160-180 days of age
- small and large adenomas are seen throughout the intestine with more lesions found in the ileum compared to Apc^tm1Cip heterozygotes

intestinal obstruction
- due to tumors

intestine polyps

rectal prolapse
- rectal prolapse is seen in 28% of surviving mutants at 7 months of age

cellular phenotype

abnormal enterocyte proliferation
- however, 17beta-estradiol replacement increases colonocyte proliferation 2-fold
- reduced proliferation of cells in the colon in ovariectomized

endocrine/exocrine gland phenotype

abnormal large intestine crypts of Lieberkuhn morphology
- ovariectomized mice exhibit reduced crypt length and distortion of surface epithelial cells in the colon compared with control mice

increased mammary adenocarcinoma incidence
- 12% of heterozygotes developed mammary adenocanthomas

hematopoietic system phenotype

anemia

Genotype: Apc^Min/Apc⁺
involves: C57BL/6 * C57BL/6J

mortality/aging

premature death
- mice die at 169 days

digestive/alimentary phenotype

intestine polyps
- mice develop more and bigger polyps than in Apc^Min Myc^tm1Jlc heterozygotes

Genotype: Apc^Min/Apc^Min
involves: C57BL/6J

cellular phenotype

abnormal cell physiology
- cultured adenomatous tissue form highly clonogenic spheroids

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Apc^Min/Apc⁺
B6.Cg-Brca2^tm1Mbn Apc^Min

growth/size/body region phenotype

decreased body weight
- body weight of mice at time of sacrifice differs significantly from Brca2-heterozygous and wild-type animals; mice show lower weight gain from start to end of experiment compared to other experimental genotypes

reproductive system phenotype

abnormal ovarian follicle morphology
- remaining follicles are degenerating in ENU-treated females

abnormal ovarian folliculogenesis
- arrested follicular development is 6-fold more prevalent compared to ENU-treated Brca2-deficient mice

abnormal vagina epithelium morphology
- reduced in thickness and lined with vacuolated cells indicative of anestrus in ENU-treated females

absent corpus luteum
- absent in 26% of ENU-treated females

absent mature ovarian follicles

ovary atrophy
- complete loss of follicles (ovarian atrophy) is observed in about 25% of ENU-treated mutants, whereas almost no incidence is observed in ENU-treated wild-type or Brca2-mutant females

reproductive system phenotype
- only observed in 1/9 ENU-treated males, similar to wild-type males (1/9)

uterus atrophy
- observed in ENU-treated females displaying ovarian failure (atrophy); endometrium and myometrium appear immature

neoplasm

increased incidence of induced tumors
- multiple intestinal tumors are observed in ENU-treated mice, similar to Apc-heterozygous mice

increased mammary gland tumor incidence
- by 65 days after ENU treatment, 100% of females develop mammary tumors with a multiplicity of 6.7 +/- 2.8
- invasion or metastases into the mammary lymph nodes was not observed during time course of study
- males develop tumors at a very low incidence and with a tumor multiplicity of 0.4 +/- 0.5, whereas no wild-type or Brca2-heterozygous males developed mammary tumors
- tumors in male and female mice are adenoacanthomas, characterized by undifferentiated acini and tubules with centrally confined squamous cells and keratin; most tumors contain proportions of adenomatous and squamous cell types
- tumors with predominantly squamous differentiation, moderate to marked inflammation in and around tumors is observed, with areas of fibrosis; in some cases, squamous component becomes cystic and is filled with keratinous debris

endocrine/exocrine gland phenotype

abnormal mammary gland development
- in ENU treated mice, male mammary ducts are elongated and in most males have extended to the lymph node of the fourth mammary gland, whereas wild-type and Brca2-heterozygous males are born with a small mammary gland rudiment, which grows no further, and no nippleno nipple
- no differences are observed in branching of female mammary glands among genotypes or wild-type females

abnormal ovarian follicle morphology
- remaining follicles are degenerating in ENU-treated females

abnormal ovarian folliculogenesis
- arrested follicular development is 6-fold more prevalent compared to ENU-treated Brca2-deficient mice

absent corpus luteum
- absent in 26% of ENU-treated females

absent mature ovarian follicles

absent nipple

adrenal gland hyperplasia
- females exhibit some adrenal hyperplasia, while none is observed in males

increased mammary gland tumor incidence
- by 65 days after ENU treatment, 100% of females develop mammary tumors with a multiplicity of 6.7 +/- 2.8
- invasion or metastases into the mammary lymph nodes was not observed during time course of study
- males develop tumors at a very low incidence and with a tumor multiplicity of 0.4 +/- 0.5, whereas no wild-type or Brca2-heterozygous males developed mammary tumors
- tumors in male and female mice are adenoacanthomas, characterized by undifferentiated acini and tubules with centrally confined squamous cells and keratin; most tumors contain proportions of adenomatous and squamous cell types
- tumors with predominantly squamous differentiation, moderate to marked inflammation in and around tumors is observed, with areas of fibrosis; in some cases, squamous component becomes cystic and is filled with keratinous debris

ovary atrophy
- complete loss of follicles (ovarian atrophy) is observed in about 25% of ENU-treated mutants, whereas almost no incidence is observed in ENU-treated wild-type or Brca2-mutant females

integument phenotype

abnormal mammary gland development
- in ENU treated mice, male mammary ducts are elongated and in most males have extended to the lymph node of the fourth mammary gland, whereas wild-type and Brca2-heterozygous males are born with a small mammary gland rudiment, which grows no further, and no nippleno nipple
- no differences are observed in branching of female mammary glands among genotypes or wild-type females

absent nipple

increased mammary gland tumor incidence
- by 65 days after ENU treatment, 100% of females develop mammary tumors with a multiplicity of 6.7 +/- 2.8
- invasion or metastases into the mammary lymph nodes was not observed during time course of study
- males develop tumors at a very low incidence and with a tumor multiplicity of 0.4 +/- 0.5, whereas no wild-type or Brca2-heterozygous males developed mammary tumors
- tumors in male and female mice are adenoacanthomas, characterized by undifferentiated acini and tubules with centrally confined squamous cells and keratin; most tumors contain proportions of adenomatous and squamous cell types
- tumors with predominantly squamous differentiation, moderate to marked inflammation in and around tumors is observed, with areas of fibrosis; in some cases, squamous component becomes cystic and is filled with keratinous debris

Genotype: Apc^Min/Apc⁺
(AKR/J x C57BL/6J-Apc^Min)F1

mortality/aging

extended life span
- Background Sensitivity - relative to heterozygous mice on an inbred C57BL/6J background

neoplasm

decreased intestinal adenoma incidence
- Background Sensitivity - decrease in the average number of tumors per mouse (6 vs 29) relative to heterozygous mice on an inbred C57BL/6J background
- however, all heterozygous mice developed tumors

increased incidence of tumors by chemical induction

increased intestinal adenocarcinoma incidence
- a range of 1 to 12 with an average of 3 adenomas were found per mouse

digestive/alimentary phenotype

decreased intestinal adenoma incidence
- Background Sensitivity - decrease in the average number of tumors per mouse (6 vs 29) relative to heterozygous mice on an inbred C57BL/6J background
- however, all heterozygous mice developed tumors

increased intestinal adenocarcinoma incidence
- a range of 1 to 12 with an average of 3 adenomas were found per mouse

cellular phenotype

aneuploidy
- quantitative polymerase chain reaction analysis of all intestinal adenomas sampled showed loss of Chr 18 carrying the wild-type Apc⁺ allele

homeostasis/metabolism phenotype

increased incidence of tumors by chemical induction

Genotype: Apc^Min/Apc⁺
(MA/MyJ x C57BL/6J-Apc^Min)F1

mortality/aging

extended life span
- Background Sensitivity - relative to heterozygous mice on an inbred C57BL/6J background

neoplasm

decreased intestinal adenoma incidence
- Background Sensitivity - decrease in the average number of tumors per mouse (6 vs 29) relative to heterozygous mice on an inbred C57BL/6J background
- however, all heterozygous mice developed tumors

digestive/alimentary phenotype

decreased intestinal adenoma incidence
- Background Sensitivity - decrease in the average number of tumors per mouse (6 vs 29) relative to heterozygous mice on an inbred C57BL/6J background
- however, all heterozygous mice developed tumors

Genotype: Apc^Min/Apc⁺
involves: AKR/J * C57BL/6J

neoplasm

increased intestinal adenocarcinoma incidence
- if mice are not anemic by 150 days of age, then tumors are not seen at 300 days of age
- locally invasive tumors seen in older animals but no metastasis
- sometimes small areas of carcinomas in anemic animals only

increased intestinal adenoma incidence
- either polyploid, papillary or sessile adenomas
- visible tumors of the large and small intestine

digestive/alimentary phenotype

increased intestinal adenocarcinoma incidence
- if mice are not anemic by 150 days of age, then tumors are not seen at 300 days of age
- locally invasive tumors seen in older animals but no metastasis
- sometimes small areas of carcinomas in anemic animals only

increased intestinal adenoma incidence
- either polyploid, papillary or sessile adenomas
- visible tumors of the large and small intestine

melena
- bloody feces

hematopoietic system phenotype

anemia
- diagnosed in mutant mice by 60 days of age
- progressive adult onset anemia beconming severe and chronic
- with few exceptions, likely the cause of lethality by 120 days of age

decreased hematocrit
- moribund animals with hematocrits around 10-20%

homeostasis/metabolism phenotype

hyperlipidemia

mortality/aging

premature death

Genotype: Apc^Min/Apc⁺
involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased intestinal adenoma incidence
- adenomas are present at 70 days of age
- loss of heterozygosity at 70 days of age is similar to heterozygous mice that are also homozygous for Foxl1^tm1Khk

neoplasm
- at 30 days, no colonic adenomas are found and normal colonic architecture and cellular morphology is observed
- no gastric adenomas are observed at 30 days of age

digestive/alimentary phenotype

increased intestinal adenoma incidence
- adenomas are present at 70 days of age
- loss of heterozygosity at 70 days of age is similar to heterozygous mice that are also homozygous for Foxl1^tm1Khk

Genotype: Apc^Min/Apc⁺
involves: 129/Sv * C57BL/6

digestive/alimentary phenotype

intestine polyps
- macroscopic lesions primarily within the proximal portion of the small intestine in mutant (n=22)

hematopoietic system phenotype

decreased NK cell number
- decreased DX5+, CD3- NK-cells in the spleen at 17 weeks old

decreased T cell number
- reduction in splenic CD3+ T cells at 17 weeks old

decreased splenocyte number
- a less pronounced reduction in immature double positive CD4+,CD8+ cells in the spleen at 17 weeks old
- a strong reduction of mature single positive CD4+ and CD8+ cells in the spleen at 17 weeks old
- decreased DX5+, CD3- NK-cells in the spleen at 17 weeks old
- reduction in splenic CD3+ T cells at 17 weeks old

immune system phenotype

decreased NK cell number
- decreased DX5+, CD3- NK-cells in the spleen at 17 weeks old

decreased T cell number
- reduction in splenic CD3+ T cells at 17 weeks old

decreased splenocyte number
- a less pronounced reduction in immature double positive CD4+,CD8+ cells in the spleen at 17 weeks old
- a strong reduction of mature single positive CD4+ and CD8+ cells in the spleen at 17 weeks old
- decreased DX5+, CD3- NK-cells in the spleen at 17 weeks old
- reduction in splenic CD3+ T cells at 17 weeks old

Genotype: Apc^Min/Apc^Min
involves: AKR/J * C57BL/6J

embryo phenotype

abnormal egg cylinder morphology
- empty space is seen in the distal region where primitive ectoderm is expected

abnormal embryo development

abnormal embryo size
- at E6.5 there is a range of abnormal development, underdeveloped embryonic tissue and associated maternal cells, with no obvious primitive ectoderm or proamniotic cavity to disorganized embryonic and extraembryonic tissue

growth/size/body region phenotype

abnormal embryo size
- at E6.5 there is a range of abnormal development, underdeveloped embryonic tissue and associated maternal cells, with no obvious primitive ectoderm or proamniotic cavity to disorganized embryonic and extraembryonic tissue

Genotype: Apc^Min/Apc^Min
involves: C57BL/6 * POMOD

embryo phenotype

abnormal embryo development
- at E7.5 embryos are disorganized,showing significant reduction in embryo growth and reduction of primitive ectoderm
- failure of primitive ectoderm development shortly after implantation

decreased embryo size
- embryos are small and embedded in maternal tissue

growth/size/body region phenotype

decreased embryo size
- embryos are small and embedded in maternal tissue

mortality/aging

embryonic lethality between implantation and placentation

embryonic lethality, complete penetrance

Genotype: Apc^Min/Apc^Min
involves: C57BL/6J * CAST/EiJ

mortality/aging

embryonic lethality, complete penetrance
- at E10.5 histological analysis shows trophoblast giant cells and a small cluster of embryonic cells, source unknown
- at E13.5 decidual swellings were necrotic with remnants of trophoblast giant cells
- inferred from no recovery of mice homozygous for embryos typed as homozygous for the identifying, linked B6 D18Mitl4 marker among a significant number of E10.5 and E13.5 progeny

References

Moser AR; Pitot HC; Dove WF. 1990. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247(4940):322-4. PubMed: 2296722 MGI: J:10209
Su LK; Kinzler KW; Vogelstein B; Preisinger AC; Moser AR; Luongo C; Gould KA; Dove WF. 1992. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene [published erratum appears in Science 1992 May 22;256(5060):1114] Science 256(5057):668-70. PubMed: 1350108 MGI: J:830

Additional References

Andreassen A; Mollersen L; Vikse R; Steffensen IL; Mikalsen A; Paulsen JE; Alexander J. 2002. One dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induces tumours in Min/+ mice by truncation mutations or LOH in the Apc gene. Mutat Res 517(1-2):157-66. PubMed: 12034317 MGI: J:77184
Andreassen A; Vikse R; Steffensen IL; Paulsen JE; Alexander J. 2001. Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo. Mutagenesis 16(4):309-15. PubMed: 11420398 MGI: J:70642
Barbour K W; Davis T; White A; Baumann H; Berger F G. 2001. Haptoglobin, inflammation, and tumorigenesis in the MIN mouse. Redox Rep 6(6):366-8. PubMed: 11865977 MGI: J:75249
Bennett LM; McAllister KA; Ward T; Malphurs J; Collins NK; Seely JC; Davis BJ; Wiseman RW. 2001. Mammary tumor induction and premature ovarian failure in ApcMin mice are not enhanced by Brca2 deficiency. Toxicol Pathol 29(1):117-25. PubMed: 11215675 MGI: J:67445
Cooper AM; Magram J; Ferrante J; Orme IM. 1997. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis. J Exp Med 186(1):39-45. PubMed: 9206995 MGI: J:41494
Davis CD; Zeng H; Finley JW. 2002. Selenium-enriched broccoli decreases intestinal tumorigenesis in multiple intestinal neoplasia mice. J Nutr 132(2):307-9. PubMed: 11823596 MGI: J:74364
De Giovanni C; Landuzzi L; Nicoletti G; Astolfi A; Croci S; Micaroni M; Nanni P; Lollini PL. 2004. Apc10.1: an ApcMin/+ intestinal cell line with retention of heterozygosity. Int J Cancer 109(2):200-6. PubMed: 14750170 MGI: J:88314
Dinchuk JE; Focht RJ; Kelley JA; Henderson NL; Zolotarjova NI; Wynn R; Neff NT; Link J; Huber RM; Burn TC; Rupar MJ; Cunningham MR; Selling BH; Ma J; Stern AA; Hollis GF; Stein RB; Friedman PA. 2002. Absence of Post-translational Aspartyl beta -Hydroxylation of Epidermal Growth Factor Domains in Mice Leads to Developmental Defects and an Increased Incidence of Intestinal Neoplasia. J Biol Chem 277(15):12970-7. PubMed: 11773073 MGI: J:75888
Erik Paulsen J; Steffensen IL; Loberg EM; Husoy T; Namork E; Alexander J. 2001. Qualitative and Quantitative Relationship between Dysplastic Aberrant Crypt Foci and Tumorigenesis in the Min/+ Mouse Colon. Cancer Res 61(13):5010-5. PubMed: 11431334 MGI: J:70170
Ernest S; Christensen B; Gilfix BM; Mamer OA; Hosack A; Rodier M; Colmenares C; McGrath J; Bale A; Balling R; Sankoff D; Rosenblatt DS; Nadeau JH. 2002. Genetic and molecular control of folate-homocysteine metabolism in mutant mice. Mamm Genome 13(5):259-67. PubMed: 12016514 MGI: J:76559
Gould TD; Gray NA; Manji HK. 2003. Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice. Pharmacol Res 48(1):49-53. PubMed: 12770514 MGI: J:84200
Greiner JW; Zeytin H; Anver MR; Schlom J. 2002. Vaccine-based therapy directed against carcinoembryonic antigen demonstrates antitumor activity on spontaneous intestinal tumors in the absence of autoimmunity. Cancer Res 62(23):6944-51. PubMed: 12460911 MGI: J:80324
Gupta RA; Wang D; Katkuri S; Wang H; Dey SK; DuBois RN. 2004. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med 10(3):245-7. PubMed: 14758356 MGI: J:88127
Gutierrez LS; Suckow M; Lawler J; Ploplis VA; Castellino FJ. 2003. Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis 24(2):199-207. PubMed: 12584168 MGI: J:79641
Hansen-Petrik MB; McEntee MF; Jull B; Shi H; Zemel MB; Whelan J. 2002. Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice. Cancer Res 62(2):403-8. PubMed: 11809688 MGI: J:74005
Hertervig E; Nilsson A; Nilbert M; Duan RD. 2003. Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation. Int J Colorectal Dis 18(4):309-13. PubMed: 12774245 MGI: J:84197
Hong KH; Bonventre JC; O'Leary E; Bonventre JV; Lander ES. 2001. Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. Proc Natl Acad Sci U S A 98(7):3935-9. PubMed: 11274413 MGI: J:68495
Huang EH; Carter JJ; Whelan RL; Liu YH; Rosenberg JO; Rotterdam H; Schmidt AM; Stern DM; Forde KA. 2002. Colonoscopy in mice. Surg Endosc 16(1):22-4. PubMed: 11961598 MGI: J:77864
Huerta S; Irwin RW; Heber D; Go VL; Koeffler HP; Uskokovic MR; Harris DM. 2002. 1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) Mouse. Cancer Res 62(3):741-6. PubMed: 11830528 MGI: J:74361
Iinuma T; Homma S; Noda T; Kufe D; Ohno T; Toda G. 2004. Prevention of gastrointestinal tumors based on adenomatous polyposis coli gene mutation by dendritic cell vaccine. J Clin Invest 113(9):1307-17. PubMed: 15124022 MGI: J:90168
Kawajiri H; Hsi LC; Kamitani H; Ikawa H; Geller M; Ward T; Eling TE; Glasgow WC. 2002. Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. Arch Biochem Biophys 398(1):51-60. PubMed: 11811948 MGI: J:74371
Lal G; Ash C; Hay K; Redston M; Kwong E; Hancock B; Mak T; Kargman S; Evans JF; Gallinger S. 2001. Suppression of intestinal polyps in msh2-deficient and non-msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. Cancer Res 61(16):6131-6. PubMed: 11507063 MGI: J:70902
Lew JI; Guo Y; Kim RK; Vargish L; Michelassi F; Arenas RB. 2002. Reduction of Intestinal Neoplasia With Adenomatous Polyposis Coli Gene Replacement and COX-2 Inhibition Is Additive. J Gastrointest Surg 6(4):563-8. PubMed: 12127122 MGI: J:77954
Lustig B; Jerchow B; Sachs M; Weiler S; Pietsch T; Karsten U; van de Wetering M; Clevers H; Schlag PM; Birchmeier W; Behrens J. 2002. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 22(4):1184-93. PubMed: 11809809 MGI: J:74286
Mabley JG; Pacher P; Bai P; Wallace R; Goonesekera S; Virag L; Southan GJ; Szabo C. 2004. Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways. Mutat Res 548(1-2):107-16. PubMed: 15063141 MGI: J:89155
Mai V; Colbert LH; Berrigan D; Perkins SN; Pfeiffer R; Lavigne JA; Lanza E; Haines DC; Schatzkin A; Hursting SD. 2003. Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms. Cancer Res 63(8):1752-5. PubMed: 12702556 MGI: J:82980
Marten K; Bremer C; Khazaie K; Sameni M; Sloane B; Tung CH; Weissleder R. 2002. Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology 122(2):406-14. PubMed: 11832455 MGI: J:74358
Mollersen L; Vikse R; Andreassen A; Steffensen IL; Mikalsen A; Paulsen JE; Alexander J. 2004. Adenomatous polyposis coli truncation mutations in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumours of multiple intestinal neoplasia mice. Mutat Res 557(1):29-40. PubMed: 14706516 MGI: J:87470
Mutanen M; Pajari AM; Oikarinen SI. 2000. Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymes. Carcinogenesis 21(6):1167-73. PubMed: 10837006 MGI: J:62978
Niho N; Takahashi M; Kitamura T; Shoji Y; Itoh M; Noda T; Sugimura T; Wakabayashi K. 2003. Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Cancer Res 63(18):6090-5. PubMed: 14522940 MGI: J:86036
Oikannen SI; Pajari A; Mutanen M. 2000. Chemopreventive activity of hydroksymatairesinol in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice Cancer Lett 159(2):183-7. PubMed: 10996730 MGI: J:64666
Oikarinen S; Heinonen S; Karppinen S; Matto J; Adlercreutz H; Poutanen K; Mutanen M. 2003. Plasma enterolactone or intestinal Bifidobacterium levels do not explain adenoma formation in multiple intestinal neoplasia (Min) mice fed with two different types of rye-bran fractions. Br J Nutr 90(1):119-25. PubMed: 12844383 MGI: J:85024
Paoni NF; Feldman MW; Gutierrez LS; Ploplis VA; Castellino FJ. 2003. Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse. Physiol Genomics 15(3):228-35. PubMed: 13130079 MGI: J:86113
Paulsen JE; Alexander J. 2001. Growth stimulation of intestinal tumours in Apc(Min/+) mice by dietary L-methionine supplementation. Anticancer Res 21(5):3281-4. PubMed: 11848484 MGI: J:75262
Paulsen JE; Namork E; Steffensen IL; Eide TJ; Alexander J. 2000. Identification and quantification of aberrant crypt foci in the colon of Min mice--a murine model of familial adenomatous polyposis Scand J Gastroenterol 35(5):534-9. PubMed: 10868458 MGI: J:62966
Perkins S; Verschoyle RD; Hill K; Parveen I; Threadgill MD; Sharma RA; Williams ML; Steward WP; Gescher AJ. 2002. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev 11(6):535-40. PubMed: 12050094 MGI: J:77168
Rao CV; Cooma I; Rodriguez JG; Simi B; El-Bayoumy K; Reddy BS. 2000. Chemoprevention of familial adenomatous polyposis development in the APC(min) mouse model by 1,4-phenylene bis(methylene)selenocyanate. Carcinogenesis 21(4):617-21. PubMed: 10753194 MGI: J:61783
Reuter BK; Zhang XJ; Miller MJ. 2002. Therapeutic utility of aspirin in the ApcMin/+ murine model of colon carcinogenesis. BMC Cancer 2(1):19. PubMed: 12171603 MGI: J:78510
Roy HK; Karoski WJ; Ratashak A; Smyrk TC. 2001. Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation. Br J Cancer 84(10):1412-6. PubMed: 11355956 MGI: J:69899
Schmelz EM; Roberts PC; Kustin EM; Lemonnier LA; Sullards MC; Dillehay DL; Merrill AH Jr. 2001. Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. Cancer Res 61(18):6723-9. PubMed: 11559543 MGI: J:71590
Shailubhai K; Yu HH; Karunanandaa K; Wang JY; Eber SL; Wang Y; Joo NS; Kim HD; Miedema BW; Abbas SZ; Boddupalli SS; Currie MG; Forte LR. 2000. Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. Cancer Res 60(18):5151-7. PubMed: 11016642 MGI: J:64784
Sibani S; Melnyk S; Pogribny IP; Wang W; Hiou-Tim F; Deng L; Trasler J; James SJ; Rozen R. 2002. Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice. Carcinogenesis 23(1):61-5. PubMed: 11756224 MGI: J:73559
Silverman KA; Koratkar RA; Siracusa LD; Buchberg AM. 2003. Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 ( Mom2) locus. Mamm Genome 14(2):119-29. PubMed: 12584607 MGI: J:81868
Sohn KJ; Choi M; Song J; Chan S; Medline A; Gallinger S; Kim YI. 2003. Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice. Carcinogenesis 24(2):217-24. PubMed: 12584170 MGI: J:79407
Song J; Medline A; Mason JB; Gallinger S; Kim YI. 2000. Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse Cancer Res 60(19):5434-40. PubMed: 11034085 MGI: J:65027
Steffensen IL; Schut HA; Paulsen JE; Andreassen A; Alexander J. 2001. Intestinal tumorigenesis in multiple intestinal neoplasia mice induced by the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: perinatal susceptibility, regional variation, and correlation with DNA adducts. Cancer Res 61(24):8689-96. PubMed: 11751386 MGI: J:73361
Suckow MA; Gutierrez LS; Risatti CA; Wolter WR; Taylor RE; Pollard M; Navari RM; Castellino FJ; Paoni NF. 2004. The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) mice. Cancer Lett 209(2):165-9. PubMed: 15159018 MGI: J:90679
Suganuma M; Ohkura Y; Okabe S; Fujiki H. 2001. Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice. J Cancer Res Clin Oncol 127(1):69-72. PubMed: 11206275 MGI: J:67939
Suzui M; Okuno M; Tanaka T; Nakagama H; Moriwaki H. 2002. Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation. Cancer Lett 183(1):31-41. PubMed: 12049812 MGI: J:77169
Symolon H; Schmelz EM; Dillehay DL; Merrill AH Jr. 2004. Dietary Soy Sphingolipids Suppress Tumorigenesis and Gene Expression in 1,2-Dimethylhydrazine-Treated CF1 Mice and Apc(Min/+) Mice. J Nutr 134(5):1157-1161. PubMed: 15113963 MGI: J:90172
Trasler J; Deng L; Melnyk S; Pogribny I; Hiou-Tim F; Sibani S; Oakes C; Li E; James SJ; Rozen R. 2003. Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice. Carcinogenesis 24(1):39-45. PubMed: 12538347 MGI: J:81577
Tucker J; Davis C; Kitchens M; Bunni M; Priest D; Spencer H; Berger F. 2002. Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice. Cancer Lett 187(1-2):153. PubMed: 12359363 MGI: J:79692
Wagenaar-Miller RA; Hanley G; Shattuck-Brandt R; DuBois RN; Bell RL; Matrisian LM; Morgan DW. 2003. Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. Br J Cancer 88(9):1445-52. PubMed: 12778076 MGI: J:83488
Wang D; Wang H; Shi Q; Katkuri S; Walhi W; Desvergne B; Das SK; Dey SK; DuBois RN. 2004. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 6(3):285-95. PubMed: 15380519 MGI: J:93551
Weber GF; Bronson RT; Ilagan J; Cantor H; Schmits R; Mak TW. 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res 62(8):2281-6. PubMed: 11956084 MGI: J:76201
Weyant MJ; Carothers AM; Dannenberg AJ; Bertagnolli MM. 2001. (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse. Cancer Res 61(1):118-25. PubMed: 11196148 MGI: J:67060
Weyant MJ; Carothers AM; Mahmoud NN; Bradlow HL; Remotti H; Bilinski RT; Bertagnolli MM. 2001. Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis. Cancer Res 61(6):2547-51. PubMed: 11289129 MGI: J:68469
Yamada T; Mori Y; Hayashi R; Takada M; Ino Y; Naishiro Y; Kondo T; Hirohashi S. 2003. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. Cancer Res 63(5):895-901. PubMed: 12615699 MGI: J:82288
Yamada Y; Hata K; Hirose Y; Hara A; Sugie S; Kuno T; Yoshimi N; Tanaka T; Mori H. 2002. Microadenomatous lesions involving loss of apc heterozygosity in the colon of adult apc(min/+) mice. Cancer Res 62(22):6367-70. PubMed: 12438216 MGI: J:80301
Yang K; Fan K; Kurihara N; Shinozaki H; Rigas B; Augenlicht L; Kopelovich L; Edelmann W; Kucherlapati R; Lipkin M. 2003. Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. Carcinogenesis 24(3):605-11. PubMed: 12663524 MGI: J:82832
Yu CF; Whiteley L; Carryl O; Basson MD. 2001. Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice. Dig Dis Sci 46(7):1367-80. PubMed: 11478486 MGI: J:70920
Ziegler CC; Rainwater L; Whelan J; McEntee MF. 2004. Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. J Nutr 134(1):5-10. PubMed: 14704285 MGI: J:88124

Additional - Apc^Min related

Ahn B; Ohshima H. 2001. Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res 61(23):8357-60. PubMed: 11731407 MGI: J:73152
Akeus P; Langenes V; Kristensen J; von Mentzer A; Sparwasser T; Raghavan S; Quiding-Jarbrink M. 2015. Treg-cell depletion promotes chemokine production and accumulation of CXCR3(+) conventional T cells in intestinal tumors. Eur J Immunol 45(6):1654-66. PubMed: 25754875 MGI: J:229714
Akitake-Kawano R; Seno H; Nakatsuji M; Kimura Y; Nakanishi Y; Yoshioka T; Kanda K; Kawada M; Kawada K; Sakai Y; Chiba T. 2013. Inhibitory role of Gas6 in intestinal tumorigenesis. Carcinogenesis 34(7):1567-74. PubMed: 23430954 MGI: J:199029
Akporiaye ET; Bradley-Dunlop D; Gendler SJ; Mukherjee P; Madsen CS; Hahn T; Besselsen DG; Dial SM; Cui H; Trevor K. 2007. Characterization of the MUC1.Tg/MIN transgenic mouse as a model for studying antigen-specific immunotherapy of adenomas. Vaccine 25(39-40):6965-74. PubMed: 17707958 MGI: J:128727
Alferez D; Wilkinson RW; Watkins J; Poulsom R; Mandir N; Wedge SR; Pyrah IT; Smith NR; Jackson L; Ryan AJ; Goodlad RA. 2008. Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice. Mol Cancer Ther 7(3):590-8. PubMed: 18347145 MGI: J:145378
Alferez DG; Ryan AJ; Goodlad RA; Wright NA; Wilkinson RW. 2010. Effects of vandetanib on adenoma formation in a dextran sodium sulphate enhanced Apc(MIN/+) mouse model. Int J Oncol 37(4):767-72. PubMed: 20811697 MGI: J:178668
Amos-Landgraf JM; Heijmans J; Wielenga MC; Dunkin E; Krentz KJ; Clipson L; Ederveen AG; Groothuis PG; Mosselman S; Muncan V; Hommes DW; Shedlovsky A; Dove WF; van den Brink GR. 2014. Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones. Proc Natl Acad Sci U S A 111(46):16514-9. PubMed: 25368192 MGI: J:216744
Andreassen A; Mollersen L; Vikse R; Steffensen IL; Mikalsen A; Paulsen JE; Alexander J. 2002. One dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induces tumours in Min/+ mice by truncation mutations or LOH in the Apc gene. Mutat Res 517(1-2):157-66. PubMed: 12034317 MGI: J:77184
Andreassen A; Vikse R; Mikalsen A; Adamovic T; Steffensen IL; Hjertholm H; Levan G; Alexander J. 2006. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces genetic changes in murine intestinal tumours and cells with Apc(Min) mutation. Mutat Res 604(1-2):60-70. PubMed: 16574467 MGI: J:107714
Andreassen A; Vikse R; Steffensen IL; Paulsen JE; Alexander J. 2001. Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo. Mutagenesis 16(4):309-15. PubMed: 11420398 MGI: J:70642
Andres SF; Simmons JG; Mah AT; Santoro MA; Van Landeghem L; Lund PK. 2013. Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation. J Cell Sci 126(Pt 24):5645-56. PubMed: 24127567 MGI: J:211908
Angus-Hill ML; Elbert KM; Hidalgo J; Capecchi MR. 2011. T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A 108(12):4914-9. PubMed: 21383188 MGI: J:170088
Aparicio T; Kotelevets L; Tsocas A; Laigneau JP; Sobhani I; Chastre E; Lehy T. 2005. Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in Apc(Min/+) mice. Gut 54(8):1136-45. PubMed: 15857934 MGI: J:194729
Arenas RB; Fichera A; Mok P; Blanco MC; Michelassi F. 1996. Introduction of human adenomatous polyposis coli gene into Min mice via cationic liposomes. Surgery 120(4):712-7. PubMed: 8862382 MGI: J:36700
Babaei-Jadidi R; Li N; Saadeddin A; Spencer-Dene B; Jandke A; Muhammad B; Ibrahim EE; Muraleedharan R; Abuzinadah M; Davis H; Lewis A; Watson S; Behrens A; Tomlinson I; Nateri AS. 2011. FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J Exp Med 208(2):295-312. PubMed: 21282377 MGI: J:176848
Bacher JW; Abdel Megid WM; Kent-First MG; Halberg RB. 2005. Use of mononucleotide repeat markers for detection of microsatellite instability in mouse tumors. Mol Carcinog 44(4):285-92. PubMed: 16240453 MGI: J:107080
Backlund MG; Mann JR; Holla VR; Buchanan FG; Tai HH; Musiek ES; Milne GL; Katkuri S; DuBois RN. 2005. 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. J Biol Chem 280(5):3217-23. PubMed: 15542609 MGI: J:105183
Backlund MG; Mann JR; Holla VR; Shi Q; Daikoku T; Dey SK; DuBois RN. 2008. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res 68(22):9331-7. PubMed: 19010907 MGI: J:141385
Baek SJ; Okazaki R; Lee SH; Martinez J; Kim JS; Yamaguchi K; Mishina Y; Martin DW; Shoieb A; McEntee MF; Eling TE. 2006. Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia. Gastroenterology 131(5):1553-60. PubMed: 17101328 MGI: J:120981
Baker DJ; Jin F; Jeganathan KB; van Deursen JM. 2009. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 16(6):475-86. PubMed: 19962666 MGI: J:155824
Baker SM; Harris AC; Tsao JL; Flath TJ; Bronner CE; Gordon M ; Shibata D ; Liskay RM. 1998. Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. Cancer Res 58(6):1087-9. PubMed: 9515784 MGI: J:46419
Baltgalvis KA; Berger FG; Pena MM; Davis JM; Carson JA. 2008. Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps. J Appl Physiol 104(4):1137-43. PubMed: 18239078 MGI: J:147321
Baltgalvis KA; Berger FG; Pena MM; Davis JM; Muga SJ; Carson JA. 2008. Interleukin-6 and cachexia in ApcMin/+ mice. Am J Physiol Regul Integr Comp Physiol 294(2):R393-401. PubMed: 18056981 MGI: J:130429
Baltgalvis KA; Berger FG; Pena MM; Mark Davis J; White JP; Carson JA. 2010. Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice. J Appl Physiol 109(4):1155-61. PubMed: 20651218 MGI: J:185914
Barak Y; Liao D; He W; Ong ES; Nelson MC; Olefsky JM; Boland R; Evans RM. 2002. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A 99(1):303-8. PubMed: 11756685 MGI: J:73557
Baran AA; Silverman KA; Zeskand J; Koratkar R; Palmer A; McCullen K; Curran WJ Jr; Edmonston TB; Siracusa LD; Buchberg AM. 2007. The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression. Genome Res 17(5):566-76. PubMed: 17387143 MGI: J:122207
Barbour K W; Davis T; White A; Baumann H; Berger F G. 2001. Haptoglobin, inflammation, and tumorigenesis in the MIN mouse. Redox Rep 6(6):366-8. PubMed: 11865977 MGI: J:75249
Barker N; van Es JH; Kuipers J; Kujala P; van den Born M; Cozijnsen M; Haegebarth A; Korving J; Begthel H; Peters PJ; Clevers H. 2007. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449(7165):1003-7. PubMed: 17934449 MGI: J:127123
Barnes CJ; Lee M. 1998. Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin. Gastroenterology 114(5):873-7. PubMed: 9558273 MGI: J:48008
Barone M; Notarnicola M; Caruso MG; Scavo MP; Viggiani MT; Tutino V; Polimeno L; Pesetti B; Di Leo A; Francavilla A. 2014. Olive oil and omega-3 polyunsaturated fatty acids suppress intestinal polyp growth by modulating the apoptotic process in ApcMin/+ mice. Carcinogenesis 35(7):1613-9. PubMed: 24632492 MGI: J:211552
Barone M; Tanzi S; Lofano K; Scavo MP; Pricci M; Demarinis L; Papagni S; Guido R; Maiorano E; Ingravallo G; Comelli MC; Francavilla A; Di Leo A. 2010. Dietary-induced ERbeta upregulation counteracts intestinal neoplasia development in intact male ApcMin/+ mice. Carcinogenesis 31(2):269-74. PubMed: 19945967 MGI: J:156778
Bashir O; FitzGerald AJ; Goodlad RA. 2004. Both suboptimal and elevated vitamin intake increase intestinal neoplasia and alter crypt fission in the ApcMin/+ mouse. Carcinogenesis 25(8):1507-15. PubMed: 15016659 MGI: J:91525
Bashir O; Fitzgerald AJ; Berlanga-Acosta J; Playford RJ; Goodlad RA. 2003. Effect of epidermal growth factor administration on intestinal cell proliferation, crypt fission and polyp formation in multiple intestinal neoplasia (Min) mice. Clin Sci (Lond) 105(3):323-330. PubMed: 12749762 MGI: J:84232
Bastide NM; Chenni F; Audebert M; Santarelli RL; Tache S; Naud N; Baradat M; Jouanin I; Surya R; Hobbs DA; Kuhnle GG; Raymond-Letron I; Gueraud F; Corpet DE; Pierre FH. 2015. A central role for heme iron in colon carcinogenesis associated with red meat intake. Cancer Res 75(5):870-9. PubMed: 25592152 MGI: J:219805
Batlle E; Bacani J; Begthel H; Jonkeer S; Gregorieff A; van de Born M; Malats N; Sancho E; Boon E; Pawson T; Gallinger S; Pals S; Clevers H. 2005. EphB receptor activity suppresses colorectal cancer progression. Nature 435(7045):1126-30. PubMed: 15973414 MGI: J:99366
Beazer-Barclay Y; Levy DB; Moser AR; Dove WF; Hamilton SR; Vogelstein B; Kinzler KW. 1996. Sulindac suppresses tumorigenesis in the Min mouse. Carcinogenesis 17(8):1757-60. PubMed: 8761438 MGI: J:101582
Belcheva A; Green B; Weiss A; Streutker C; Martin A. 2013. Elevated incidence of polyp formation in APC(Min/(+))Msh2(-)/(-) mice is independent of nitric oxide-induced DNA mutations. PLoS One 8(5):e65204. PubMed: 23741483 MGI: J:200824
Belcheva A; Irrazabal T; Robertson SJ; Streutker C; Maughan H; Rubino S; Moriyama EH; Copeland JK; Kumar S; Green B; Geddes K; Pezo RC; Navarre WW; Milosevic M; Wilson BC; Girardin SE; Wolever TM; Edelmann W; Guttman DS; Philpott DJ; Martin A. 2014. Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. Cell 158(2):288-99. PubMed: 25036629 MGI: J:214622
Bellafante E; Morgano A; Salvatore L; Murzilli S; Di Tullio G; D'Orazio A; Latorre D; Villani G; Moschetta A. 2014. PGC-1beta promotes enterocyte lifespan and tumorigenesis in the intestine. Proc Natl Acad Sci U S A 111(42):E4523-31. PubMed: 25288742 MGI: J:216428
Bellis J; Duluc I; Romagnolo B; Perret C; Faux MC; Dujardin D; Formstone C; Lightowler S; Ramsay RG; Freund JN; De Mey JR. 2012. The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. J Cell Biol 198(3):331-41. PubMed: 22851318 MGI: J:191316
Bennett LM; McAllister KA; Ward T; Malphurs J; Collins NK; Seely JC; Davis BJ; Wiseman RW. 2001. Mammary tumor induction and premature ovarian failure in ApcMin mice are not enhanced by Brca2 deficiency. Toxicol Pathol 29(1):117-25. PubMed: 11215675 MGI: J:67445
Berger FG; Kramer DL; Porter CW. 2007. Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse. Biochem Soc Trans 35(Pt 2):336-9. PubMed: 17371273 MGI: J:122673
Bhandaru M; Kempe DS; Rotte A; Rexhepaj R; Kuhl D; Lang F. 2009. Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC. Am J Physiol Regul Integr Comp Physiol 297(3):R571-5. PubMed: 19494170 MGI: J:152204
Bilger A; Shoemaker AR; Gould KA; Dove WF. 1996. Manipulation of the mouse germline in the study of Min-induced neoplasia. Semin Cancer Biol 7(5):249-60. PubMed: 9110402 MGI: J:40100
Bilger A; Sullivan R; Prunuske AJ; Clipson L; Drinkwater NR; Dove WF. 2008. Widespread hyperplasia induced by transgenic TGFalpha in ApcMin mice is associated with only regional effects on tumorigenesis. Carcinogenesis 29(9):1825-30. PubMed: 18310091 MGI: J:139925
Bjerknes M; Cheng H. 1999. Colossal crypts bordering colon adenomas in Apc(Min) mice express full-length Apc. Am J Pathol 154(6):1831-4. PubMed: 10362808 MGI: J:55509
Blanc V; Henderson JO; Newberry RD; Xie Y; Cho SJ; Newberry EP; Kennedy S; Rubin DC; Wang HL; Luo J; Davidson NO. 2007. Deletion of the AU-Rich RNA Binding Protein Apobec-1 Reduces Intestinal Tumor Burden in Apcmin Mice. Cancer Res 67(18):8565-73. PubMed: 17875695 MGI: J:124876
Bobe G; Wang B; Seeram NP; Nair MG; Bourquin LD. 2006. Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac. J Agric Food Chem 54(25):9322-8. PubMed: 17147414 MGI: J:121119
Bogan C; Chen J; O'Sullivan MG; Cormier RT. 2009. Loss of EphA2 receptor tyrosine kinase reduces ApcMin/+ tumorigenesis. Int J Cancer 124(6):1366-71. PubMed: 19089910 MGI: J:147511
Boily G; He XH; Pearce B; Jardine K; McBurney MW. 2009. SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol. Oncogene 28(32):2882-93. PubMed: 19503100 MGI: J:153925
Boivin GP; Washington K; Yang K; Ward JM; Pretlow TP; Russell R; Besselsen DG; Godfrey VL; Doetschman T; Dove WF; Pitot HC; Halberg RB; Itzkowitz SH; Groden J; Coffey RJ. 2003. Pathology of mouse models of intestinal cancer: consensus report and recommendations. Gastroenterology 124(3):762-77. PubMed: 12612914 MGI: J:82108
Bonetto A; Aydogdu T; Jin X; Zhang Z; Zhan R; Puzis L; Koniaris LG; Zimmers TA. 2012. JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia. Am J Physiol Endocrinol Metab 303(3):E410-21. PubMed: 22669242 MGI: J:187289
Boolbol SK; Dannenberg AJ; Chadburn A; Martucci C; Guo XJ; Ramonetti JT; Abreu-Goris M; Newmark HL; Lipkin ML; DeCosse JJ; Bertagnolli MM. 1996. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res 56(11):2556-60. PubMed: 8653697 MGI: J:33982
Boquoi A; Jover R; Chen T; Pennings M; Enders GH. 2009. Transgenic expression of VEGF in intestinal epithelium drives mesenchymal cell interactions and epithelial neoplasia. Gastroenterology 136(2):596-606.e4. PubMed: 19056388 MGI: J:146074
Bossuyt W; Kazanjian A; De Geest N; Van Kelst S; De Hertogh G; Geboes K; Boivin GP; Luciani J; Fuks F; Chuah M; VandenDriessche T; Marynen P; Cools J; Shroyer NF; Hassan BA. 2009. Atonal homolog 1 is a tumor suppressor gene. PLoS Biol 7(2):e39. PubMed: 19243219 MGI: J:145954
Botrugno OA; Fayard E; Annicotte JS; Haby C; Brennan T; Wendling O; Tanaka T; Kodama T; Thomas W; Auwerx J; Schoonjans K. 2004. Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol Cell 15(4):499-509. PubMed: 15327767 MGI: J:92508
Boudreau F; Lussier CR; Mongrain S; Darsigny M; Drouin JL; Doyon G; Suh ER; Beaulieu JF; Rivard N; Perreault N. 2007. Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia. FASEB J 21(14):3853-65. PubMed: 17622569 MGI: J:134918
Brown AR; Simmen RC; Raj VR; Van TT; MacLeod SL; Simmen FA. 2015. Kruppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling. Carcinogenesis 36(9):946-55. PubMed: 26210742 MGI: J:225893
Buchert M; Athineos D; Abud HE; Burke ZD; Faux MC; Samuel MS; Jarnicki AG; Winbanks CE; Newton IP; Meniel VS; Suzuki H; Stacker SA; Nathke IS; Tosh D; Huelsken J; Clarke AR; Heath JK; Sansom OJ; Ernst M. 2010. Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet 6(1):e1000816. PubMed: 20084116 MGI: J:156864
Buchert M; Rohde F; Eissmann M; Tebbutt N; Williams B; Tan CW; Owen A; Hirokawa Y; Gnann A; Orend G; Orner G; Dashwood RH; Heath JK; Ernst M; Janssen KP. 2015. A hypermorphic epithelial beta-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations. Dis Model Mech 8(11):1361-73. PubMed: 26398937 MGI: J:226549
Bugni JM; Meira LB; Samson LD. 2009. Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins. Oncogene 28(5):734-41. PubMed: 19029948 MGI: J:145871
Buller NV; Rosekrans SL; Metcalfe C; Heijmans J; van Dop WA; Fessler E; Jansen M; Ahn C; Vermeulen JL; Westendorp BF; Robanus-Maandag EC; Offerhaus GJ; Medema JP; D'Haens GR; Wildenberg ME; de Sauvage FJ; Muncan V; van den Brink GR. 2015. Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice. Gastroenterology 148(1):170-180.e6. PubMed: 25307863 MGI: J:232543
Busquets L; Guillen H; DeFord ME; Suckow MA; Navari RM; Castellino FJ; Prorok M. 2006. Cathepsin E is a specific marker of dysplasia in APC mouse intestine. Tumour Biol 27(1):36-42. PubMed: 16340248 MGI: J:106940
Cai H; Al-Fayez M; Tunstall RG; Platton S; Greaves P; Steward WP; Gescher AJ. 2005. The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice. Mol Cancer Ther 4(9):1287-92. PubMed: 16170019 MGI: J:103610
Cai H; Marczylo TH; Teller N; Brown K; Steward WP; Marko D; Gescher AJ. 2010. Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: Pharmacodynamic changes and anthocyanin levels in the murine biophase. Eur J Cancer 46(4):811-817. PubMed: 20060287 MGI: J:157156
Cai H; Scott E; Kholghi A; Andreadi C; Rufini A; Karmokar A; Britton RG; Horner-Glister E; Greaves P; Jawad D; James M; Howells L; Ognibene T; Malfatti M; Goldring C; Kitteringham N; Walsh J; Viskaduraki M; West K; Miller A; Hemingway D; Steward WP; Gescher AJ; Brown K. 2015. Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice. Sci Transl Med 7(298):298ra117. PubMed: 26223300 MGI: J:227778
Cai J; Maitra A; Anders RA; Taketo MM; Pan D. 2015. beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Genes Dev 29(14):1493-506. PubMed: 26193883 MGI: J:226066
Caldwell CM; Green RA; Kaplan KB. 2007. APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. J Cell Biol 178(7):1109-20. PubMed: 17893240 MGI: J:134792
Cao H; Xu M; Dong W; Deng B; Wang S; Zhang Y; Wang S; Luo S; Wang W; Qi Y; Gao J; Cao X; Yan F; Wang B. 2017. Secondary bile acid-induced dysbiosis promotes intestinal carcinogenesis. Int J Cancer 140(11):2545-2556. PubMed: 28187526 MGI: J:241300
Cao L; Liu X; Lin EJ; Wang C; Choi EY; Riban V; Lin B; During MJ. 2010. Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition. Cell 142(1):52-64. PubMed: 20603014 MGI: J:167939
Carothers AM; Davids JS; Damas BC; Bertagnolli MM. 2010. Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis. Cancer Res 70(11):4433-42. PubMed: 20484034 MGI: J:160685
Carothers AM; Javid SH; Moran AE; Hunt DH; Redston M; Bertagnolli MM. 2006. Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility. Exp Cell Res 312(4):387-400. PubMed: 16368433 MGI: J:105729
Cebrat M; Strzadala L; Kisielow P. 2004. Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells. Cancer Lett 206(1):107-13. PubMed: 15019166 MGI: J:88778
Chadeneau C; LeCabellec M; LeMoullac B; Meflah K; Denis MG. 1996. Over-expression of a novel member of the immunoglobulin superfamily in Min mouse intestinal adenomas. Int J Cancer 68(6):817-21. PubMed: 8980189 MGI: J:37448
Chae WJ; Bothwell AL. 2011. IL-17F deficiency inhibits small intestinal tumorigenesis in ApcMin/+ mice. Biochem Biophys Res Commun 414(1):31-6. PubMed: 21939640 MGI: J:178487
Chae WJ; Gibson TF; Zelterman D; Hao L; Henegariu O; Bothwell AL. 2010. Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis. Proc Natl Acad Sci U S A 107(12):5540-4. PubMed: 20212110 MGI: J:158691
Chandrakesan P; Jakkula LU; Ahmed I; Roy B; Anant S; Umar S. 2013. Differential effects of beta-catenin and NF-kappaB interplay in the regulation of cell proliferation, inflammation and tumorigenesis in response to bacterial infection. PLoS One 8(11):e79432. PubMed: 24278135 MGI: J:209657
Chazaud C; Rossant J. 2006. Disruption of early proximodistal patterning and AVE formation in Apc mutants. Development 133(17):3379-87. PubMed: 16887818 MGI: J:112232
Cheasley D; Pereira L; Lightowler S; Vincan E; Malaterre J; Ramsay RG. 2011. Myb controls intestinal stem cell genes and self-renewal. Stem Cells 29(12):2042-50. PubMed: 21997934 MGI: J:190196
Cheasley D; Pereira L; Sampurno S; Sieber O; Jorissen R; Xu H; Germann M; Yuqian Y; Ramsay RG; Malaterre J. 2015. Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis. Mol Cancer Res 13(8):1185-96. PubMed: 25934694 MGI: J:224943
Chen GY; Shaw MH; Redondo G; Nunez G. 2008. The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. Cancer Res 68(24):10060-7. PubMed: 19074871 MGI: J:142241
Chen KJ; Lizaso A; Lee YH. 2014. SIM2 maintains innate host defense of the small intestine. Am J Physiol Gastrointest Liver Physiol 307(11):G1044-56. PubMed: 25277798 MGI: J:227825
Chesnokova V; Zonis S; Zhou C; Recouvreux MV; Ben-Shlomo A; Araki T; Barrett R; Workman M; Wawrowsky K; Ljubimov VA; Uhart M; Melmed S. 2016. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A 113(23):E3250-9. PubMed: 27226307 MGI: J:234102
Cheung AF; Carter AM; Kostova KK; Woodruff JF; Crowley D; Bronson RT; Haigis KM; Jacks T. 2010. Complete deletion of Apc results in severe polyposis in mice. Oncogene 29(12):1857-64. PubMed: 20010873 MGI: J:160399
Cheung EC; Lee P; Ceteci F; Nixon C; Blyth K; Sansom OJ; Vousden KH. 2016. Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes Dev 30(1):52-63. PubMed: 26679840 MGI: J:227691
Chinen T; Kannan AK; Levine AG; Fan X; Klein U; Zheng Y; Gasteiger G; Feng Y; Fontenot JD; Rudensky AY. 2016. An essential role for the IL-2 receptor in Treg cell function. Nat Immunol 17(11):1322-1333. PubMed: 27595233 MGI: J:237689
Chivukula RR; Shi G; Acharya A; Mills EW; Zeitels LR; Anandam JL; Abdelnaby AA; Balch GC; Mansour JC; Yopp AC; Maitra A; Mendell JT. 2014. An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration. Cell 157(5):1104-16. PubMed: 24855947 MGI: J:214382
Cho NL; Javid SH; Carothers AM; Redston M; Bertagnolli MM. 2007. Estrogen receptors alpha and beta are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice. Cancer Res 67(5):2366-72. PubMed: 17332369 MGI: J:118600
Chudnovskiy A; Mortha A; Kana V; Kennard A; Ramirez JD; Rahman A; Remark R; Mogno I; Ng R; Gnjatic S; Amir ED; Solovyov A; Greenbaum B; Clemente J; Faith J; Belkaid Y; Grigg ME; Merad M. 2016. Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome. Cell 167(2):444-456.e14. PubMed: 27716507 MGI: J:236522
Chulada PC; Thompson MB; Mahler JF; Doyle CM; Gaul BW; Lee C; Tiano HF; Morham SG; Smithies O; Langenbach R. 2000. Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res 60(17):4705-8. PubMed: 10987272 MGI: J:64401
Chung AY; Li Q; Blair SJ; De Jesus M; Dennis KL; LeVea C; Yao J; Sun Y; Conway TF; Virtuoso LP; Battaglia NG; Furtado S; Mathiowitz E; Mantis NJ; Khazaie K; Egilmez NK. 2014. Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells. Cancer Res 74(19):5377-85. PubMed: 25228656 MGI: J:216986
Ciznadija D; Tothill R; Waterman ML; Zhao L; Huynh D; Yu RM; Ernst M; Ishii S; Mantamadiotis T; Gonda TJ; Ramsay RG; Malaterre J. 2009. Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling. Cell Death Differ 16(11):1530-8. PubMed: 19609274 MGI: J:169282
Clarke AR; Cummings MC; Harrison DJ. 1995. Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy. Oncogene 11(9):1913-20. PubMed: 7478622 MGI: J:29664
Cleveland AG; Oikarinen SI; Bynote KK; Marttinen M; Rafter JJ; Gustafsson JA; Roy SK; Pitot HC; Korach KS; Lubahn DB; Mutanen M; Gould KA. 2009. Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice. Carcinogenesis 30(9):1581-90. PubMed: 19520794 MGI: J:152202
Cohenford MA; Lim S; Brown C; Chaudhry MA; Sigdel S; Beckelhimer E; Rigas B. 2012. FT-IR microspectroscopy of mouse colon tissues: insight into the chemistry of carcinogenesis and diagnostic potential. Am J Pathol 181(6):1961-8. PubMed: 23063512 MGI: J:190722
Colbert LH; Davis JM; Essig DA; Ghaffar A; Mayer EP. 2000. Exercise and tumor development in a mouse predisposed to multiple intestinal adenomas. Med Sci Sports Exerc 32(10):1704-8. PubMed: 11039641 MGI: J:65357
Colbert LH; Mai V; Perkins SN; Berrigan D; Lavigne JA; Wimbrow HH; Alvord WG; Haines DC; Srinivas P; Hursting SD. 2003. Exercise and intestinal polyp development in APCMin mice. Med Sci Sports Exerc 35(10):1662-9. PubMed: 14523302 MGI: J:101440
Colbert LH; Mai V; Tooze JA; Perkins SN; Berrigan D; Hursting SD. 2006. Negative energy balance induced by voluntary wheel running inhibits polyp development in APCMin mice. Carcinogenesis 27(10):2103-7. PubMed: 16699175 MGI: J:113355
Cole AM; Myant K; Reed KR; Ridgway RA; Athineos D; Van den Brink GR; Muncan V; Clevers H; Clarke AR; Sicinski P; Sansom OJ. 2010. Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Res 70(20):8149-58. PubMed: 20736363 MGI: J:165592
Cole AR; Ji H; Simpson RJ. 2000. Proteomic analysis of colonic crypts from normal, multiple intestinal neoplasia and p53-null mice: a comparison with colonic polyps Electrophoresis 21(9):1772-81. PubMed: 10870964 MGI: J:62965
Coletta PL; Muller AM; Jones EA; Muhl B; Holwell S; Clarke D; Meade JL; Cook GP; Hawcroft G; Ponchel F; Lam WK; MacLennan KA; Hull MA; Bonifer C; Markham AF. 2004. Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis. Blood 103(3):1050-8. PubMed: 14525778 MGI: J:87640
Collett GP; Robson CN; Mathers JC; Campbell FC. 2001. Curcumin modifies Apc(min) apoptosis resistance and inhibits 2-amino 1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced tumour formation in Apc(min) mice. Carcinogenesis 22(5):821-5. PubMed: 11323404 MGI: J:69213
Colnot S; Niwa-Kawakita M; Hamard G; Godard C; Le Plenier S; Houbron C; Romagnolo B; Berrebi D; Giovannini M; Perret C. 2004. Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. Lab Invest 84(12):1619-30. PubMed: 15502862 MGI: J:94108
Cooper HS; Chang WC; Coudry R; Gary MA; Everley L; Spittle CS; Wang H; Litwin S; Clapper ML. 2005. Generation of a unique strain of multiple intestinal neoplasia (Apc(+/Min-FCCC)) mice with significantly increased numbers of colorectal adenomas. Mol Carcinog 44(1):31-41. PubMed: 15937958 MGI: J:101103
Cooper HS; Everley L; Chang WC; Pfeiffer G; Lee B; Murthy S; Clapper ML. 2001. The role of mutant apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis. Gastroenterology 121(6):1407-16. PubMed: 11729120 MGI: J:72879
Cordero JB; Ridgway RA; Valeri N; Nixon C; Frame MC; Muller WJ; Vidal M; Sansom OJ. 2014. c-Src drives intestinal regeneration and transformation. EMBO J 33(13):1474-91. PubMed: 24788409 MGI: J:211668
Cormier RT; Dove WF. 2000. Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res 60(14):3965-70. PubMed: 10919675 MGI: J:63662
Cormier RT; Hong KH; Halberg RB; Hawkins TL; Richardson P; Mulherkar R ; Dove WF ; Lander ES. 1997. Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis [see comments] Nat Genet 17(1):88-91. PubMed: 9288104 MGI: J:42722
Corpet DE; Pierre F. 2003. Point: from animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. Cancer Epidemiol Biomarkers Prev 12(5):391-400. PubMed: 12750232 MGI: J:84217
Cortina C; Palomo-Ponce S; Iglesias M; Fernandez-Masip JL; Vivancos A; Whissell G; Huma M; Peiro N; Gallego L; Jonkheer S; Davy A; Lloreta J; Sancho E; Batlle E. 2007. EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nat Genet 39(11):1376-83. PubMed: 17906625 MGI: J:130035
Crist RC; Roth JJ; Baran AA; McEntee BJ; Siracusa LD; Buchberg AM. 2010. The armadillo repeat domain of Apc suppresses intestinal tumorigenesis. Mamm Genome 21(9-10):450-7. PubMed: 20886217 MGI: J:202877
Crist RC; Roth JJ; Lisanti MP; Siracusa LD; Buchberg AM. 2011. Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis. Cell Cycle 10(7):1092-9. PubMed: 21386660 MGI: J:201191
Cuthbert RJ; Wilson JM; Scott N; Coletta PL; Hull MA. 2009. Differential CD74 (major histocompatibility complex Class II invariant chain) expression in mouse and human intestinal adenomas. Eur J Cancer 45(9):1654-63. PubMed: 19269807 MGI: J:148998
Czarnomska A; Krysiak E; Piskorowska J; Sitarz M; Pysniak K; Pilcik T; Demant P. 2003. Opposite effects of modifiers of the ApcMin mutation in intestine and mammary gland. Cancer Res 63(15):4533-7. PubMed: 12907628 MGI: J:85697
D'Errico I; Salvatore L; Murzilli S; Lo Sasso G; Latorre D; Martelli N; Egorova AV; Polishuck R; Madeyski-Bengtson K; Lelliott C; Vidal-Puig AJ; Seibel P; Villani G; Moschetta A. 2011. Peroxisome proliferator-activated receptor-{gamma} coactivator 1-{alpha} (PGC1{alpha}) is a metabolic regulator of intestinal epithelial cell fate. Proc Natl Acad Sci U S A 108(16):6603-8. PubMed: 21467224 MGI: J:171361
Dahlhoff M; Horst D; Gerhard M; Kolligs FT; Wolf E; Schneider MR. 2008. Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc(+/Min) mice. FEBS Lett 582(19):2911-5. PubMed: 18656477 MGI: J:138998
Dang DT; Bachman KE; Mahatan CS; Dang LH; Giardiello FM; Yang VW. 2000. Decreased expression of the gut-enriched Kruppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients FEBS Lett 476(3):203-7. PubMed: 10913614 MGI: J:63496
Darsigny M; Babeu JP; Seidman EG; Gendron FP; Levy E; Carrier J; Perreault N; Boudreau F. 2010. Hepatocyte nuclear factor-4alpha promotes gut neoplasia in mice and protects against the production of reactive oxygen species. Cancer Res 70(22):9423-33. PubMed: 21062980 MGI: J:166855
Datta K; Suman S; Kallakury BV; Fornace AJ Jr. 2013. Heavy ion radiation exposure triggered higher intestinal tumor frequency and greater beta-catenin activation than gamma radiation in APC(Min/+) mice. PLoS One 8(3):e59295. PubMed: 23555653 MGI: J:199886
Davies CC; Chakraborty A; Cipriani F; Haigh K; Haigh JJ; Behrens A. 2010. Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation. Nat Cell Biol 12(10):963-72. PubMed: 20852630 MGI: J:173145
Davis CD; Newman S. 2000. Inadequate dietary copper increases tumorigenesis in the min mouse Cancer Lett 159(1):57-62. PubMed: 10974406 MGI: J:64669
Davis CD; Zeng H; Finley JW. 2002. Selenium-enriched broccoli decreases intestinal tumorigenesis in multiple intestinal neoplasia mice. J Nutr 132(2):307-9. PubMed: 11823596 MGI: J:74364
Davis H; Lewis A; Behrens A; Tomlinson I. 2013. Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. Gut :. PubMed: 23676439 MGI: J:197128
De Simone V; Franze E; Ronchetti G; Colantoni A; Fantini MC; Di Fusco D; Sica GS; Sileri P; MacDonald TT; Pallone F; Monteleone G; Stolfi C. 2015. Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene 34(27):3493-503. PubMed: 25174402 MGI: J:222525
Degg NL; Weil MM; Edwards A; Haines J; Coster M; Moody J; Ellender M; Cox R; Silver A. 2003. Adenoma multiplicity in irradiated apc(min) mice is modified by chromosome 16 segments from BALB/c. Cancer Res 63(10):2361-3. PubMed: 12750251 MGI: J:83497
Demidov ON; Timofeev O; Lwin HN; Kek C; Appella E; Bulavin DV. 2007. Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine. Cell Stem Cell 1(2):180-90. PubMed: 18371349 MGI: J:139068
Demidov ON; Zhu Y; Kek C; Goloudina AR; Motoyama N; Bulavin DV. 2012. Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis. Cell Death Differ 19(11):1761-8. PubMed: 22555459 MGI: J:204789
Deming DA; Leystra AA; Nettekoven L; Sievers C; Miller D; Middlebrooks M; Clipson L; Albrecht D; Bacher J; Washington MK; Weichert J; Halberg RB. 2014. PIK3CA and APC mutations are synergistic in the development of intestinal cancers. Oncogene 33(17):2245-54. PubMed: 23708654 MGI: J:212593
Deng Z; Mu J; Tseng M; Wattenberg B; Zhuang X; Egilmez NK; Wang Q; Zhang L; Norris J; Guo H; Yan J; Haribabu B; Miller D; Zhang HG. 2015. Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis. Nat Commun 6:6956. PubMed: 25907800 MGI: J:222801
Diefenbacher ME; Chakraborty A; Blake SM; Mitter R; Popov N; Eilers M; Behrens A. 2015. Usp28 counteracts fbw7 in intestinal homeostasis and cancer. Cancer Res 75(7):1181-6. PubMed: 25716680 MGI: J:220157
Diefenbacher ME; Popov N; Blake SM; Schulein-Volk C; Nye E; Spencer-Dene B; Jaenicke LA; Eilers M; Behrens A. 2014. The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. J Clin Invest 124(8):3407-18. PubMed: 24960159 MGI: J:213781
Dietrich CG; Vehr AK; Martin IV; Gassler N; Rath T; Roeb E; Schmitt J; Trautwein C; Geier A. 2011. Downregulation of breast cancer resistance protein in colon adenomas reduces cellular xenobiotic resistance and leads to accumulation of a food-derived carcinogen. Int J Cancer 129(3):546-552. PubMed: 21544799 MGI: J:173406
Dietrich WF; Lander ES; Smith JS; Moser AR; Gould KA; Luongo C; Borenstein N; Dove W. 1993. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 75(4):631-9. PubMed: 8242739 MGI: J:15703
Dillon RL; Muller WJ. 2010. Distinct biological roles for the akt family in mammary tumor progression. Cancer Res 70(11):4260-4. PubMed: 20424120 MGI: J:160703
Dinchuk JE; Focht RJ; Kelley JA; Henderson NL; Zolotarjova NI; Wynn R; Neff NT; Link J; Huber RM; Burn TC; Rupar MJ; Cunningham MR; Selling BH; Ma J; Stern AA; Hollis GF; Stein RB; Friedman PA. 2002. Absence of Post-translational Aspartyl beta -Hydroxylation of Epidermal Growth Factor Domains in Mice Leads to Developmental Defects and an Increased Incidence of Intestinal Neoplasia. J Biol Chem 277(15):12970-7. PubMed: 11773073 MGI: J:75888
Ding S; McEntee MF; Whelan J; Zemel M. 2007. Adiposity-related protection of intestinal tumorigenesis: interaction with dietary calcium. Nutr Cancer 58(2):153-61. PubMed: 17640161 MGI: J:138109
Doerner SK; Reis ES; Leung ES; Ko JS; Heaney JD; Berger NA; Lambris JD; Nadeau JH. 2016. High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity. Mol Cancer Res 14(10):953-965. PubMed: 27535705 MGI: J:236248
Dominguez-Brauer C; Hao Z; Elia AJ; Fortin JM; Nechanitzky R; Brauer PM; Sheng Y; Mana MD; Chio II; Haight J; Pollett A; Cairns R; Tworzyanski L; Inoue S; Reardon C; Marques A; Silvester J; Cox MA; Wakeham A; Yilmaz OH; Sabatini DM; van Es JH; Clevers H; Sato T; Mak TW. 2016. Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell 19(2):205-16. PubMed: 27184401 MGI: J:238103
Dominguez-Brauer C; Khatun R; Elia AJ; Thu KL; Ramachandran P; Baniasadi SP; Hao Z; Jones LD; Haight J; Sheng Y; Mak TW. 2017. E3 ubiquitin ligase Mule targets beta-catenin under conditions of hyperactive Wnt signaling. Proc Natl Acad Sci U S A 114(7):E1148-E1157. PubMed: 28137882 MGI: J:240933
Dong R; Gong Y; Meng W; Yuan M; Zhu H; Ying M; He Q; Cao J; Yang B. 2017. The involvement of M2 macrophage polarization inhibition in fenretinide-mediated chemopreventive effects on colon cancer. Cancer Lett 388:43-53. PubMed: 27913199 MGI: J:239398
Dopeso H; Mateo-Lozano S; Mazzolini R; Rodrigues P; Lagares-Tena L; Ceron J; Romero J; Esteves M; Landolfi S; Hernandez-Losa J; Castano J; Wilson AJ; Ramon y Cajal S; Mariadason JM; Schwartz S Jr; Arango D. 2009. The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis. Cancer Res 69(18):7430-8. PubMed: 19738063 MGI: J:152683
Dove WF; Clipson L; Gould KA; Luongo C; Marshall DJ; Moser AR; Newton MA; Jacoby RF. 1997. Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status. Cancer Res 57(5):812-4. PubMed: 9041176 MGI: J:38777
Dove WF; Cormier RT; Gould KA; Halberg RB; Merritt AJ; Newton MA; Shoemaker AR. 1998. The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions. Philos Trans R Soc Lond B Biol Sci 353(1370):915-23. PubMed: 9684289 MGI: J:52642
Dove WF; Shedlovsky A; Clipson L; Amos-Landgraf JM; Halberg RB; Krentz KJ; Boehm FJ; Newton MA; Adams DJ; Keane TM. 2014. A strategy to identify dominant point mutant modifiers of a quantitative trait. G3 (Bethesda) 4(6):1113-21. PubMed: 24747760 MGI: J:218513
Du Q; Zhang X; Liu Q; Zhang X; Bartels CE; Geller DA. 2013. Nitric oxide production upregulates Wnt/beta-catenin signaling by inhibiting Dickkopf-1. Cancer Res 73(21):6526-37. PubMed: 24008318 MGI: J:204521
Dube PE; Yan F; Punit S; Girish N; McElroy SJ; Washington MK; Polk DB. 2012. Epidermal growth factor receptor inhibits colitis-associated cancer in mice. J Clin Invest 122(8):2780-92. PubMed: 22772467 MGI: J:190076
Dudley ME; Sundberg JP; Roopenian DC. 1996. Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation. Int J Cancer 65(2):249-53. PubMed: 8567125 MGI: J:31690
Eads CA; Nickel AE; Laird PW. 2002. Complete Genetic Suppression of Polyp Formation and Reduction of CpG-Island Hypermethylation in Apc(Min/+) Dnmt1-Hypomorphic Mice. Cancer Res 62(5):1296-9. PubMed: 11888894 MGI: J:75230
Easwaran V; Lee SH; Inge L; Guo L; Goldbeck C; Garrett E; Wiesmann M; Garcia PD; Fuller JH; Chan V; Randazzo F; Gundel R; Warren RS; Escobedo J; Aukerman SL; Taylor RN; Fantl WJ. 2003. beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res 63(12):3145-53. PubMed: 12810642 MGI: J:84505
Elahi E; Suraweera N; Volikos E; Haines J; Brown N; Davidson G; Churchman M; Ilyas M; Tomlinson I; Silver A. 2009. Five quantitative trait Loci control radiation-induced adenoma multiplicity in Mom 1R Apc Min/+ mice. PLoS One 4(2):e4388. PubMed: 19194513 MGI: J:146495
Elander N; Ungerback J; Olsson H; Uematsu S; Akira S; Soderkvist P. 2008. Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. Biochem Biophys Res Commun 372(1):249-53. PubMed: 18485889 MGI: J:136951
Ellender M; Harrison JD; Edwards AA; Bouffler SD; Cox R. 2005. Direct single gene mutational events account for radiation-induced intestinal adenoma yields in apc(min/+) mice. Radiat Res 163(5):552-6. PubMed: 15850417 MGI: J:98647
Enquist IB; Good Z; Jubb AM; Fuh G; Wang X; Junttila MR; Jackson EL; Leong KG. 2014. Lymph node-independent liver metastasis in a model of metastatic colorectal cancer. Nat Commun 5:3530. PubMed: 24667486 MGI: J:210473
Erdman SE; Rao VP; Olipitz W; Taylor CL; Jackson EA; Levkovich T; Lee CW; Horwitz BH; Fox JG; Ge Z; Poutahidis T. 2010. Unifying roles for regulatory T cells and inflammation in cancer. Int J Cancer 126(7):1651-65. PubMed: 19795459 MGI: J:160425
Erdman SE; Sohn JJ; Rao VP; Nambiar PR; Ge Z; Fox JG; Schauer DB. 2005. CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice. Cancer Res 65(10):3998-4004. PubMed: 15899788 MGI: J:98546
Erdman SH; Ignatenko NA; Powell MB; Blohm-Mangone KA; Holubec H; Guillen-Rodriguez JM; Gerner EW. 1999. APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse. Carcinogenesis 20(9):1709-13. PubMed: 10469614 MGI: J:57289
Erik Paulsen J; Steffensen IL; Loberg EM; Husoy T; Namork E; Alexander J. 2001. Qualitative and Quantitative Relationship between Dysplastic Aberrant Crypt Foci and Tumorigenesis in the Min/+ Mouse Colon. Cancer Res 61(13):5010-5. PubMed: 11431334 MGI: J:70170
Ermakova O; Piszczek L; Luciani L; Cavalli FM; Ferreira T; Farley D; Rizzo S; Paolicelli RC; Al-Banchaabouchi M; Nerlov C; Moriggl R; Luscombe NM; Gross C. 2011. Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice. EMBO Mol Med 3(1):50-66. PubMed: 21204268 MGI: J:232020
Ermakova O; Salimova E; Piszczek L; Gross C. 2012. Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus. Mamm Genome 23(7-8):443-53. PubMed: 22772436 MGI: J:190754
Ernest S; Christensen B; Gilfix BM; Mamer OA; Hosack A; Rodier M; Colmenares C; McGrath J; Bale A; Balling R; Sankoff D; Rosenblatt DS; Nadeau JH. 2002. Genetic and molecular control of folate-homocysteine metabolism in mutant mice. Mamm Genome 13(5):259-67. PubMed: 12016514 MGI: J:76559
Evans PM; Chen X; Zhang W; Liu C. 2010. KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin. Mol Cell Biol 30(2):372-81. PubMed: 19901072 MGI: J:156407
Fancy SP; Baranzini SE; Zhao C; Yuk DI; Irvine KA; Kaing S; Sanai N; Franklin RJ; Rowitch DH. 2009. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev 23(13):1571-85. PubMed: 19515974 MGI: J:150044
Farrall AL; Riemer P; Leushacke M; Sreekumar A; Grimm C; Herrmann BG; Morkel M. 2012. Wnt and BMP signals control intestinal adenoma cell fates. Int J Cancer 131(10):2242-52. PubMed: 22344573 MGI: J:187862
Fazeli A; Dickinson SL; Hermiston ML; Tighe RV; Steen RG; Small CG; Stoeckli ET; Keino-Masu K; Masu M; Rayburn H; Simons J; Bronson RT; Gordon JI; Tessier-Lavigne M; Weinberg RA. 1997. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 386(6627):796-804. PubMed: 9126737 MGI: J:39765
Fazeli A; Steen RG; Dickinson SL; Bautista D; Dietrich WF; Bronson RT ; Bresalier RS ; Lander ES ; Costa J ; Weinberg RA. 1997. Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas. Proc Natl Acad Sci U S A 94(19):10199-204. PubMed: 9294187 MGI: J:42974
Fein M; Peters JH; Baril N; McGarvey M; Chandrasoma P; Shibata D ; Laird PW ; Skinner KA. 1999. Loss of function of Trp53, but not Apc, leads to the development of esophageal adenocarcinoma in mice with jejunoesophageal reflux. J Surg Res 83(1):48-55. PubMed: 10210642 MGI: J:55225
Field MS; Anderson DD; Stover PJ. 2011. Mthfs is an Essential Gene in Mice and a Component of the Purinosome. Front Genet 2:36. PubMed: 22303332 MGI: J:185874
Fingleton B; Carter KJ; Matrisian LM. 2007. Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model. Cancer Res 67(10):4800-6. PubMed: 17510409 MGI: J:121728
Firestein R; Blander G; Michan S; Oberdoerffer P; Ogino S; Campbell J; Bhimavarapu A; Luikenhuis S; de Cabo R; Fuchs C; Hahn WC; Guarente LP; Sinclair DA. 2008. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3(4):e2020. PubMed: 18414679 MGI: J:134301
Fischer JM; Miller AJ; Shibata D; Liskay RM. 2012. Different phenotypic consequences of simultaneous versus stepwise Apc loss. Oncogene 31(16):2028-38. PubMed: 21892206 MGI: J:186141
Fodde R; Edelmann W; Yang K; van Leeuwen C; Carlson C; Renault B; Breukel C; Alt E; Lipkin M; Khan PM; Kucherlapati R. 1994. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A 91(19):8969-73. PubMed: 8090754 MGI: J:20443
Forn M; Diez-Villanueva A; Merlos-Suarez A; Munoz M; Lois S; Carrio E; Jorda M; Bigas A; Batlle E; Peinado MA. 2015. Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression. PLoS One 10(5):e0123263. PubMed: 25933092 MGI: J:235092
Fothergill T; Donahoo AL; Douglass A; Zalucki O; Yuan J; Shu T; Goodhill GJ; Richards LJ. 2014. Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion. Cereb Cortex 24(5):1138-51. PubMed: 23302812 MGI: J:220581
Frank H; Groger N; Diener M; Becker C; Braun T; Boettger T. 2008. Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. J Biol Chem 283(36):24729-37. PubMed: 18562324 MGI: J:139883
Friedrich T; Richter B; Gaiser T; Weiss C; Janssen KP; Einwachter H; Schmid RM; Ebert MP; Burgermeister E. 2013. Deficiency of caveolin-1 in Apcmin/+ mice promotes colorectal tumorigenesis. Carcinogenesis 34(9):2109-18. PubMed: 23640045 MGI: J:200094
Fujimoto K; Fujii G; Taguchi K; Yasuda K; Matsuo Y; Hashiyama A; Mutoh M; Tanaka H; Wada M. 2015. Involvement of trefoil factor family 2 in the enlargement of intestinal tumors in Apc(Min/+) mice. Biochem Biophys Res Commun 463(4):859-63. PubMed: 26056002 MGI: J:228700
Fyrst H; Oskouian B; Bandhuvula P; Gong Y; Byun HS; Bittman R; Lee AR; Saba JD. 2009. Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis. Cancer Res 69(24):9457-64. PubMed: 19934323 MGI: J:155537
Galli GG; Multhaupt HA; Carrara M; de Lichtenberg KH; Christensen IB; Linnemann D; Santoni-Rugiu E; Calogero RA; Lund AH. 2014. Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression. Oncogene 33(25):3342-50. PubMed: 23873026 MGI: J:212619
Gallot YS; Durieux AC; Castells J; Desgeorges MM; Vernus B; Plantureux L; Remond D; Jahnke VE; Lefai E; Dardevet D; Nemoz G; Schaeffer L; Bonnieu A; Freyssenet DG. 2014. Myostatin gene inactivation prevents skeletal muscle wasting in cancer. Cancer Res 74(24):7344-56. PubMed: 25336187 MGI: J:218089
Gao C; Chen G; Kuan SF; Zhang DH; Schlaepfer DD; Hu J. 2015. FAK/PYK2 promotes the Wnt/beta-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3beta. Elife 4:. PubMed: 26274564 MGI: J:226719
Gao FJ; Shi L; Hines T; Hebbar S; Neufeld KL; Smith DS. 2017. Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol Biol Cell 28(5):587-599. PubMed: 28057765 MGI: J:240425
Garg R; Benedetti LG; Abera MB; Wang H; Abba M; Kazanietz MG. 2014. Protein kinase C and cancer: what we know and what we do not. Oncogene 33(45):5225-37. PubMed: 24336328 MGI: J:216553
Gaspar C; Franken P; Molenaar L; Breukel C; van der Valk M; Smits R; Fodde R. 2009. A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. PLoS Genet 5(7):e1000547. PubMed: 19578404 MGI: J:151494
Genander M; Halford MM; Xu NJ; Eriksson M; Yu Z; Qiu Z; Martling A; Greicius G; Thakar S; Catchpole T; Chumley MJ; Zdunek S; Wang C; Holm T; Goff SP; Pettersson S; Pestell RG; Henkemeyer M; Frisen J. 2009. Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell 139(4):679-92. PubMed: 19914164 MGI: J:157019
Gerner EW. 2007. Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models. Biochem Soc Trans 35(Pt 2):322-5. PubMed: 17371270 MGI: J:122674
Ghaleb AM; Elkarim EA; Bialkowska AB; Yang VW. 2016. KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis. Mol Cancer Res 14(4):385-96. PubMed: 26839262 MGI: J:235544
Ghaleb AM; McConnell BB; Nandan MO; Katz JP; Kaestner KH; Yang VW. 2007. Haploinsufficiency of Kruppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res 67(15):7147-54. PubMed: 17671182 MGI: J:123915
Giammanco A; Blanc V; Montenegro G; Klos C; Xie Y; Kennedy S; Luo J; Chang SH; Hla T; Nalbantoglu I; Dharmarajan S; Davidson NO. 2014. Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. Cancer Res 74(18):5322-35. PubMed: 25085247 MGI: J:215982
Gibson SL; Dai CY; Lee HW; DePinho RA; Gee MS; Lee WM; Furth EE; Brensinger C; Enders GH. 2003. Inhibition of colon tumor progression and angiogenesis by the ink4a/arf locus. Cancer Res 63(4):742-6. PubMed: 12591718 MGI: J:81942
Giroux V; Lemay F; Bernatchez G; Robitaille Y; Carrier JC. 2008. Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice. Int J Cancer 123(2):303-11. PubMed: 18464259 MGI: J:138676
Glading AJ; Ginsberg MH. 2010. Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling. Dis Model Mech 3(1-2):73-83. PubMed: 20007487 MGI: J:157670
Goktuna SI; Canli O; Bollrath J; Fingerle AA; Horst D; Diamanti MA; Pallangyo C; Bennecke M; Nebelsiek T; Mankan AK; Lang R; Artis D; Hu Y; Patzelt T; Ruland J; Kirchner T; Taketo MM; Chariot A; Arkan MC; Greten FR. 2014. IKKalpha Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells. Cell Rep 7(6):1914-25. PubMed: 24882009 MGI: J:211784
Goktuna SI; Shostak K; Chau TL; Heukamp LC; Hennuy B; Duong HQ; Ladang A; Close P; Klevernic I; Olivier F; Florin A; Ehx G; Baron F; Vandereyken M; Rahmouni S; Vereecke L; van Loo G; Buttner R; Greten FR; Chariot A. 2016. The Prosurvival IKK-Related Kinase IKKepsilon Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine. Cancer Res 76(9):2587-99. PubMed: 26980769 MGI: J:231832
Goodlad RA; Ryan AJ; Wedge SR; Pyrah IT; Alferez D; Poulsom R; Smith NR; Mandir N; Watkins AJ; Wilkinson RW. 2006. Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer. Carcinogenesis 27(10):2133-9. PubMed: 16782971 MGI: J:113371
Goodwin AC; Shields CE; Wu S; Huso DL; Wu X; Murray-Stewart TR; Hacker-Prietz A; Rabizadeh S; Woster PM; Sears CL; Casero RA Jr. 2011. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc Natl Acad Sci U S A 108(37):15354-9. PubMed: 21876161 MGI: J:176447
Goss KH; Risinger MA; Kordich JJ; Sanz MM; Straughen JE; Slovek LE; Capobianco AJ; German J; Boivin GP; Groden J. 2002. Enhanced tumor formation in mice heterozygous for Blm mutation. Science 297(5589):2051-3. PubMed: 12242442 MGI: J:79058
Goss KJ; Brown PD; Matrisian LM. 1998. Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis. Int J Cancer 78(5):629-35. PubMed: 9808534 MGI: J:50603
Gould KA; Dietrich WF; Borenstein N; Lander ES; Dove WF. 1996. Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics 144(4):1769-76. PubMed: 8978062 MGI: J:37224
Gould KA; Luongo C; Moser AR; McNeley MK; Borenstein N; Shedlovsky A; Dove WF; Hong K; Dietrich WF; Lander ES. 1996. Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice. Genetics 144(4):1777-85. PubMed: 8978063 MGI: J:37223
Gould TD; Gray NA; Manji HK. 2003. Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice. Pharmacol Res 48(1):49-53. PubMed: 12770514 MGI: J:84200
Gounaris E; Erdman SE; Restaino C; Gurish MF; Friend DS; Gounari F; Lee DM; Zhang G; Glickman JN; Shin K; Rao VP; Poutahidis T; Weissleder R; McNagny KM; Khazaie K. 2007. Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A 104(50):19977-82. PubMed: 18077429 MGI: J:128606
Gregorieff A; Liu Y; Inanlou MR; Khomchuk Y; Wrana JL. 2015. Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer. Nature 526(7575):715-8. PubMed: 26503053 MGI: J:226759
Greiner JW; Zeytin H; Anver MR; Schlom J. 2002. Vaccine-based therapy directed against carcinoembryonic antigen demonstrates antitumor activity on spontaneous intestinal tumors in the absence of autoimmunity. Cancer Res 62(23):6944-51. PubMed: 12460911 MGI: J:80324
Grill JI; Herbst A; Brandl L; Kong L; Schneider MR; Kirchner T; Wolf E; Kolligs FT. 2015. Inactivation of Itf2 promotes intestinal tumorigenesis in Apc(Min/+) mice. Biochem Biophys Res Commun 461(2):249-53. PubMed: 25869068 MGI: J:228385
Grill JI; Neumann J; Herbst A; Hiltwein F; Ofner A; Marschall MK; Wolf E; Kirchner T; Goke B; Schneider MR; Kolligs FT. 2014. DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice. Mol Cancer Res 12(11):1655-62. PubMed: 25053805 MGI: J:216704
Grimm C; Chavez L; Vilardell M; Farrall AL; Tierling S; Bohm JW; Grote P; Lienhard M; Dietrich J; Timmermann B; Walter J; Schweiger MR; Lehrach H; Herwig R; Herrmann BG; Morkel M. 2013. DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer. PLoS Genet 9(2):e1003250. PubMed: 23408899 MGI: J:195142
Guglietta S; Chiavelli A; Zagato E; Krieg C; Gandini S; Ravenda PS; Bazolli B; Lu B; Penna G; Rescigno M. 2016. Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis. Nat Commun 7:11037. PubMed: 26996437 MGI: J:236748
Guillen-Ahlers H; Buechler SA; Suckow MA; Castellino FJ; Ploplis VA. 2008. Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice. Carcinogenesis 29(7):1421-7. PubMed: 18499699 MGI: J:139063
Guillen-Ahlers H; Suckow MA; Castellino FJ; Ploplis VA. 2010. Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden. PLoS One 5(2):e9070. PubMed: 20140201 MGI: J:158010
Guilmeau S; Flandez M; Mariadason JM; Augenlicht LH. 2010. Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling. Oncogene 29(7):992-1002. PubMed: 19935714 MGI: J:160403
Gupta RA; Wang D; Katkuri S; Wang H; Dey SK; DuBois RN. 2004. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med 10(3):245-7. PubMed: 14758356 MGI: J:88127
Gutierrez LS; Suckow M; Lawler J; Ploplis VA; Castellino FJ. 2003. Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis 24(2):199-207. PubMed: 12584168 MGI: J:79641
Haigis KM; Dove WF. 2003. A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity. Nat Genet 33(1):33-9. PubMed: 12447373 MGI: J:80330
Haigis KM; Hoff PD; White A; Shoemaker AR; Halberg RB; Dove WF. 2004. Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. Proc Natl Acad Sci U S A 101(26):9769-73. PubMed: 15210940 MGI: J:91411
Haines J; Dunford R; Moody J; Ellender M; Cox R; Silver A. 2000. Loss of heterozygosity in spontaneous and x-ray-induced intestinal tumors arising in F1 hybrid min mice: evidence for sequential loss of apc(+) and dpc4 in tumor development Genes Chromosomes Cancer 28(4):387-94. PubMed: 10862047 MGI: J:62971
Haines J; Johnson V; Pack K; Suraweera N; Slijepcevic P; Cabuy E; Coster M; Ilyas M; Wilding J; Sieber O; Bodmer W; Tomlinson I; Silver A. 2005. Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice. Proc Natl Acad Sci U S A 102(8):2868-73. PubMed: 15710876 MGI: J:96833
Haines JW; Coster MR; Adam J; Cheeseman M; Ainsbury EA; Thacker J; Bouffler SD. 2010. Xrcc2 modulates spontaneous and radiation-induced tumorigenesis in Apcmin/+ mice. Mol Cancer Res 8(9):1227-33. PubMed: 20671066 MGI: J:205233
Halberg RB; Chen X; Amos-Landgraf JM; White A; Rasmussen K; Clipson L; Pasch C; Sullivan R; Pitot HC; Dove WF. 2008. The pleiotropic phenotype of apc mutations in the mouse: allele specificity and effects of the genetic background. Genetics 180(1):601-9. PubMed: 18723878 MGI: J:139675
Halberg RB; Katzung DS; Hoff PD; Moser AR; Cole CE; Lubet RA; Donehower LA; Jacoby RF; Dove WF. 2000. Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A 97(7):3461-6. PubMed: 10716720 MGI: J:61200
Halberg RB; Larsen MC; Elmergreen TL; Ko AY; Irving AA; Clipson L; Jefcoate CR. 2008. Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates. Cancer Res 68(18):7394-402. PubMed: 18794127 MGI: J:141215
Halberg RB; Waggoner J; Rasmussen K; White A; Clipson L; Prunuske AJ; Bacher JW; Sullivan R; Washington MK; Pitot HC; Petrini JH; Albertson DG; Dove WF. 2009. Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway. Cancer Res 69(14):5768-75. PubMed: 19584276 MGI: J:150641
Hamilton KE; Noubissi FK; Katti PS; Hahn CM; Davey SR; Lundsmith ET; Klein-Szanto AJ; Rhim AD; Spiegelman VS; Rustgi AK. 2013. IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis 34(11):2647-54. PubMed: 23764754 MGI: J:202774
Han YM; Park JM; Cha JY; Jeong M; Go EJ; Hahm KB. 2016. Endogenous conversion of omega-6 to omega-3 polyunsaturated fatty acids in fat-1 mice attenuated intestinal polyposis by either inhibiting COX-2/beta-catenin signaling or activating 15-PGDH/IL-18. Int J Cancer 138(9):2247-56. PubMed: 26650508 MGI: J:237658
Hance KW; Zeytin HE; Greiner JW. 2005. Mouse models expressing human carcinoembryonic antigen (CEA) as a transgene: evaluation of CEA-based cancer vaccines. Mutat Res 576(1-2):132-54. PubMed: 15888344 MGI: J:100615
Hansen-Petrik MB; McEntee MF; Jull B; Shi H; Zemel MB; Whelan J. 2002. Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice. Cancer Res 62(2):403-8. PubMed: 11809688 MGI: J:74005
Hao F; Pysz MA; Curry KJ; Haas KN; Seedhouse SJ; Black AR; Black JD. 2011. Protein Kinase C{alpha} Signaling Regulates Inhibitor of DNA Binding 1 in the Intestinal Epithelium. J Biol Chem 286(20):18104-17. PubMed: 21454537 MGI: J:172682
Hariri LP; Tumlinson AR; Besselsen DG; Utzinger U; Gerner EW; Barton JK. 2006. Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model. Lasers Surg Med 38(4):305-13. PubMed: 16596657 MGI: J:115751
Harman FS; Nicol CJ; Marin HE; Ward JM; Gonzalez FJ; Peters JM. 2004. Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis. Nat Med 10(5):481-483. PubMed: 15048110 MGI: J:90217
Harper J; Burns JL; Foulstone EJ; Pignatelli M; Zaina S; Hassan AB. 2006. Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting. Cancer Res 66(4):1940-8. PubMed: 16488992 MGI: J:106661
Hashimoto K; Yamada Y; Semi K; Yagi M; Tanaka A; Itakura F; Aoki H; Kunisada T; Woltjen K; Haga H; Sakai Y; Yamamoto T; Yamada Y. 2017. Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior. Proc Natl Acad Sci U S A 114(4):758-763. PubMed: 28057861 MGI: J:239530
Hassan AB; Howell JA. 2000. Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice. Cancer Res 60(4):1070-6. PubMed: 10706126 MGI: J:61216
Hasson RM; Briggs A; Carothers AM; Davids JS; Wang J; Javid SH; Cho NL; Bertagnolli MM. 2014. Estrogen receptor alpha or beta loss in the colon of Min/+ mice promotes crypt expansion and impairs TGFbeta and HNF3beta signaling. Carcinogenesis 35(1):96-102. PubMed: 24104551 MGI: J:206078
Hasson RM; Briggs A; Rizvi H; Carothers AM; Davids JS; Bertagnolli MM; Cho NL. 2014. Lack of anti-tumor activity with the beta-catenin expression inhibitor EZN-3892 in the C57BL/6J Min/+ model of intestinal carcinogenesis. Biochem Biophys Res Commun 444(3):283-9. PubMed: 24486542 MGI: J:219148
Hata K; Tanaka T; Kohno H; Suzuki R; Qiang SH; Yamada Y; Oyama T; Kuno T; Hirose Y; Hara A; Mori H. 2006. beta-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice. Cancer Lett 239(1):123-8. PubMed: 16168560 MGI: J:114612
Hatano Y; Semi K; Hashimoto K; Lee MS; Hirata A; Tomita H; Kuno T; Takamatsu M; Aoki K; Taketo MM; Kim YJ; Hara A; Yamada Y. 2015. Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation. Carcinogenesis 36(7):719-29. PubMed: 25939752 MGI: J:222770
He XY; Xiang C; Zhang CX; Xie YY; Chen L; Zhang GX; Lu Y; Liu G. 2015. p53 in the Myeloid Lineage Modulates an Inflammatory Microenvironment Limiting Initiation and Invasion of Intestinal Tumors. Cell Rep 13(5):888-97. PubMed: 26565902 MGI: J:228954
Heijmans J; Buller NV; Hoff E; Dihal AA; van der Poll T; van Zoelen MA; Bierhaus A; Biemond I; Hardwick JC; Hommes DW; Muncan V; van den Brink GR. 2013. Rage signalling promotes intestinal tumourigenesis. Oncogene 32(9):1202-6. PubMed: 22469986 MGI: J:193364
Heijmans J; Muncan V; Jacobs RJ; de Jonge-Muller ES; Graven L; Biemond I; Ederveen AG; Groothuis PG; Mosselman S; Hardwick JC; Hommes DW; van den Brink GR. 2011. Intestinal tumorigenesis is not affected by progesterone signaling in rodent models. PLoS One 6(7):e22620. PubMed: 21818351 MGI: J:175854
Hensley HH; Chang WC; Clapper ML. 2004. Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging. Magn Reson Med 52(3):524-9. PubMed: 15334570 MGI: J:92889
Hetzler KL; Hardee JP; Puppa MJ; Narsale AA; Sato S; Davis JM; Carson JA. 2015. Sex differences in the relationship of IL-6 signaling to cancer cachexia progression. Biochim Biophys Acta 1852(5):816-25. PubMed: 25555992 MGI: J:234458
Hirata A; Utikal J; Yamashita S; Aoki H; Watanabe A; Yamamoto T; Okano H; Bardeesy N; Kunisada T; Ushijima T; Hara A; Jaenisch R; Hochedlinger K; Yamada Y. 2013. Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development 140(1):66-75. PubMed: 23222438 MGI: J:191050
Holcomb VB; Rodier F; Choi Y; Busuttil RA; Vogel H; Vijg J; Campisi J; Hasty P. 2008. Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res 68(22):9497-502. PubMed: 19010925 MGI: J:141382
Holopainen T; Lopez-Alpuche V; Zheng W; Heljasvaara R; Jones D; He Y; Tvorogov D; D'Amico G; Wiener Z; Andersson LC; Pihlajaniemi T; Min W; Alitalo K. 2012. Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res 72(14):3512-21. PubMed: 22593188 MGI: J:189306
Hong KH; Bonventre JC; O'Leary E; Bonventre JV; Lander ES. 2001. Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. Proc Natl Acad Sci U S A 98(7):3935-9. PubMed: 11274413 MGI: J:68495
Hoshiko S; Kawaguchi M; Fukushima T; Haruyama Y; Yorita K; Tanaka H; Seiki M; Inatsu H; Kitamura K; Kataoka H. 2013. Hepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis. Cancer Res 73(8):2659-70. PubMed: 23447577 MGI: J:197057
Hu R; Khor TO; Shen G; Jeong WS; Hebbar V; Chen C; Xu C; Reddy B; Chada K; Kong AN. 2006. Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis 27(10):2038-46. PubMed: 16675473 MGI: J:113352
Hu Y; Le Leu RK; Young GP. 2007. Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindac. Cancer Lett 248(2):234-44. PubMed: 16950562 MGI: J:120014
Huang EH; Park JC; Appelman H; Weinberg AD; Banerjee M; Logsdon CD; Schmidt AM. 2006. Induction of inflammatory bowel disease accelerates adenoma formation in Min +/- mice. Surgery 139(6):782-8. PubMed: 16782435 MGI: J:115828
Huber S; Gagliani N; Zenewicz LA; Huber FJ; Bosurgi L; Hu B; Hedl M; Zhang W; O'Connor W Jr; Murphy AJ; Valenzuela DM; Yancopoulos GD; Booth CJ; Cho JH; Ouyang W; Abraham C; Flavell RA. 2012. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491(7423):259-63. PubMed: 23075849 MGI: J:189217
Huerta S; Irwin RW; Heber D; Go VL; Koeffler HP; Uskokovic MR; Harris DM. 2002. 1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) Mouse. Cancer Res 62(3):741-6. PubMed: 11830528 MGI: J:74361
Huerta S; Irwin RW; Heber D; Go VL; Moatamed F; Huerta S; Ou C; Harris DM. 2003. Intestinal polyp formation in the Apcmin mouse: effects of levels of dietary calcium and altered vitamin D homeostasis. Dig Dis Sci 48(5):870-6. PubMed: 12772782 MGI: J:84198
Hulboy DL; Gautam S; Fingleton B; Matrisian LM. 2004. The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncol Rep 12(1):13-7. PubMed: 15201952 MGI: J:91647
Hulit J; Wang C; Li Z; Albanese C; Rao M; Di Vizio D; Shah S; Byers SW; Mahmood R; Augenlicht LH; Russell R; Pestell RG. 2004. Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. (Erratum: v 25(1):523) Mol Cell Biol 24(17):7598-611. PubMed: 15314168 MGI: J:92787
Hull MA; Booth JK; Tisbury A; Scott N; Bonifer C; Markham AF; Coletta PL. 1999. Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice. Br J Cancer 79(9-10):1399-405. PubMed: 10188882 MGI: J:53622
Hull MA; Faluyi OO; Ko CW; Holwell S; Scott DJ; Cuthbert RJ; Poulsom R; Goodlad R; Bonifer C; Markham AF; Coletta PL. 2006. Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis. Carcinogenesis 27(3):382-91. PubMed: 16219637 MGI: J:106584
Husoy T; Abramsson-Zetterberg L; Olstorn HB; Paulsen JE; Alexander J. 2005. Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes. Mutat Res 580(1-2):111-8. PubMed: 15668113 MGI: J:95966
Husoy T; Knutsen HK; Cruciani V; Olstorn HB; Mikalsen SO; Loberg EM; Alexander J. 2005. Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts. Int J Cancer 116(3):351-8. PubMed: 15800939 MGI: J:98957
Ignatenko NA; Holubec H; Besselsen DG; Blohm-Mangone KA; Padilla-Torres JL; Nagle RB; de Alboranc IM; Guillen-R JM; Gerner EW. 2006. Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse. Cancer Biol Ther 5(12):1658-64. PubMed: 17106247 MGI: J:120790
Iguchi G; Chrysovergis K; Lee SH; Baek SJ; Langenbach R; Eling TE. 2009. A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. Cancer Lett 282(2):152-8. PubMed: 19375854 MGI: J:150685
Ikuta T; Kobayashi Y; Kitazawa M; Shiizaki K; Itano N; Noda T; Pettersson S; Poellinger L; Fujii-Kuriyama Y; Taniguchi S; Kawajiri K. 2013. ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice. Carcinogenesis 34(7):1620-7. PubMed: 23455376 MGI: J:199027
Irving AA; Halberg RB; Albrecht DM; Plum LA; Krentz KJ; Clipson L; Drinkwater N; Amos-Landgraf JM; Dove WF; DeLuca HF. 2011. Supplementation by vitamin D compounds does not affect colonic tumor development in vitamin D sufficient murine models. Arch Biochem Biophys 515(1-2):64-71. PubMed: 21907701 MGI: J:189361
Ito K; Lim AC; Salto-Tellez M; Motoda L; Osato M; Chuang LS; Lee CW; Voon DC; Koo JK; Wang H; Fukamachi H; Ito Y. 2008. RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell 14(3):226-37. PubMed: 18772112 MGI: J:141161
Jacoby RF; Cole CE; Hawk ET; Lubet RA. 2004. Ursodeoxycholate/Sulindac combination treatment effectively prevents intestinal adenomas in a mouse model of polyposis. Gastroenterology 127(3):838-44. PubMed: 15362039 MGI: J:93405
Jacoby RF; Cole CE; Tutsch K; Newton MA; Kelloff G; Hawk ET; Lubet RA. 2000. Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos Cancer Res 60(7):1864-70. PubMed: 10766173 MGI: J:61461
Jacoby RF; Marshall DJ; Newton MA; Novakovic K; Tutsch K; Cole CE; Lubet RA; Kelloff GJ; Verma A; Moser AR; Dove WF. 1996. Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam. Cancer Res 56(4):710-4. PubMed: 8631000 MGI: J:79095
Jacoby RF; Seibert K; Cole CE; Kelloff G; Lubet RA. 2000. The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. Cancer Res 60(18):5040-4. PubMed: 11016626 MGI: J:64781
Jalving M; Heijink DM; Koornstra JJ; Boersma-van Ek W; Zwart N; Wesseling J; Sluiter WJ; de Vries EG; Kleibeuker JH; de Jong S. 2014. Regulation of TRAIL receptor expression by beta-catenin in colorectal tumours. Carcinogenesis 35(5):1092-9. PubMed: 24379239 MGI: J:209057
Jamieson T; Clarke M; Steele CW; Samuel MS; Neumann J; Jung A; Huels D; Olson MF; Das S; Nibbs RJ; Sansom OJ. 2012. Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J Clin Invest 122(9):3127-44. PubMed: 22922255 MGI: J:190744
Jamin EL; Riu A; Douki T; Debrauwer L; Cravedi JP; Zalko D; Audebert M. 2013. Combined genotoxic effects of a polycyclic aromatic hydrocarbon (B(a)P) and an heterocyclic amine (PhIP) in relation to colorectal carcinogenesis. PLoS One 8(3):e58591. PubMed: 23484039 MGI: J:200196
Javid SH; Moran AE; Carothers AM; Redston M; Bertagnolli MM. 2005. Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer. Carcinogenesis 26(3):587-95. PubMed: 15579483 MGI: J:96347
Jiang L; Hermeking H. 2017. miR-34a and miR-34b/c Suppress Intestinal Tumorigenesis. Cancer Res 77(10):2746-2758. PubMed: 28363996 MGI: J:242141
Jiang L; Yang S; Yin H; Fan X; Wang S; Yao B; Pozzi A; Chen X; Harris RC; Zhang MZ. 2013. Epithelial-specific deletion of 11beta-HSD2 hinders Apcmin/+ mouse tumorigenesis. Mol Cancer Res 11(9):1040-50. PubMed: 23741059 MGI: J:205456
Johnson L; Mercer K; Greenbaum D; Bronson RT; Crowley D; Tuveson DA; Jacks T. 2001. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410(6832):1111-6. PubMed: 11323676 MGI: J:68981
Jones LE Jr; Ying L; Hofseth AB; Jelezcova E; Sobol RW; Ambs S; Harris CC; Espey MG; Hofseth LJ; Wyatt MD. 2009. Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase. Carcinogenesis 30(12):2123-9. PubMed: 19864471 MGI: J:155345
Ju J; Hong J; Zhou JN; Pan Z; Bose M; Liao J; Yang GY; Liu YY; Hou Z; Lin Y; Ma J; Shih WJ; Carothers AM; Yang CS. 2005. Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer Res 65(22):10623-31. PubMed: 16288056 MGI: J:103400
Jubb AM; Strickland LA; Liu SD; Mak J; Schmidt M; Koeppen H. 2012. Neuropilin-1 expression in cancer and development. J Pathol 226(1):50-60. PubMed: 22025255 MGI: J:180262
Kakuni M; Morimura K; Wanibuchi H; Ogawa M; Min W; Hayashi S; Fukushima S. 2002. Food restriction inhibits the growth of intestinal polyps in multiple intestinal neoplasia mouse. Jpn J Cancer Res 93(3):236-41. PubMed: 11927003 MGI: J:76214
Kang DW; Choi CY; Cho YH; Tian H; Di Paolo G; Choi KY; Min do S. 2015. Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling beta-catenin signaling in cancer-initiating cells. J Exp Med 212(8):1219-37. PubMed: 26122663 MGI: J:226449
Kang DW; Lee SW; Hwang WC; Lee BH; Choi YS; Suh YA; Choi KY; Min DS. 2017. Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. Cancer Res 77(1):142-152. PubMed: 27793841 MGI: J:237995
Karabinis ME; Larson D; Barlow C; Wynshaw-Boris A; Moser AR. 2001. Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice. Carcinogenesis 22(2):343-6. PubMed: 11181458 MGI: J:67485
Katoh H; Wang D; Daikoku T; Sun H; Dey SK; Dubois RN. 2013. CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis. Cancer Cell 24(5):631-44. PubMed: 24229710 MGI: J:206735
Kawajiri K; Kobayashi Y; Ohtake F; Ikuta T; Matsushima Y; Mimura J; Pettersson S; Pollenz RS; Sakaki T; Hirokawa T; Akiyama T; Kurosumi M; Poellinger L; Kato S; Fujii-Kuriyama Y. 2009. Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc Natl Acad Sci U S A 106(32):13481-6. PubMed: 19651607 MGI: J:151997
Kawasaki Y; Tsuji S; Muroya K; Furukawa S; Shibata Y; Okuno M; Ohwada S; Akiyama T. 2009. The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. EMBO Rep 10(12):1355-62. PubMed: 19893577 MGI: J:157023
Kechele DO; Blue RE; Zwarycz B; Espenschied ST; Mah AT; Siegel MB; Perou CM; Ding S; Magness ST; Lund PK; Caron KM. 2017. Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest 127(2):593-607. PubMed: 28094771 MGI: J:239820
Keku TO; Dulal S; Deveaux A; Jovov B; Han X. 2015. The gastrointestinal microbiota and colorectal cancer. Am J Physiol Gastrointest Liver Physiol 308(5):G351-63. PubMed: 25540232 MGI: J:224038
Keller RR; Gestl SA; Lu AQ; Hoke A; Feith DJ; Gunther EJ. 2016. Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias. Carcinogenesis 37(8):810-6. PubMed: 27207659 MGI: J:233956
Kemp CJ; Sun S; Gurley KE. 2001. p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent. Cancer Res 61(1):327-32. PubMed: 11196181 MGI: J:67062
Kennedy AR; Beazer-Barclay Y; Kinzler KW; Newberne PM. 1996. Suppression of carcinogenesis in the intestines of min mice by the soybean-derived Bowman-Birk inhibitor. Cancer Res 56(4):679-82. PubMed: 8630994 MGI: J:101589
Kettunen HL; Kettunen AS; Rautonen NE. 2003. Intestinal immune responses in wild-type and Apcmin/+ mouse, a model for colon cancer. Cancer Res 63(16):5136-42. PubMed: 12941845 MGI: J:85142
Khor TO; Cheung WK; Prawan A; Reddy BS; Kong AN. 2008. Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC). Mol Carcinog 47(5):321-5. PubMed: 17932952 MGI: J:133548
Kim DJ; Akiyama TE; Harman FS; Burns AM; Shan W; Ward JM; Kennett MJ; Gonzalez FJ; Peters JM. 2004. Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis. J Biol Chem 279(22):23719-27. PubMed: 15033975 MGI: J:90337
Kim DJ; Roh E; Lee MH; Oi N; Lim do Y; Kim MO; Cho YY; Pugliese A; Shim JH; Chen H; Cho EJ; Kim JE; Kang SC; Paul S; Kang HE; Jung JW; Lee SY; Kim SH; Reddy K; Yeom YI; Bode AM; Dong Z. 2016. Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity. Cancer Res 76(5):1146-57. PubMed: 26676750 MGI: J:237652
Kim HA; Koo BK; Cho JH; Kim YY; Seong J; Chang HJ; Oh YM; Stange DE; Park JG; Hwang D; Kong YY. 2012. Notch1 counteracts WNT/beta-catenin signaling through chromatin modification in colorectal cancer. J Clin Invest 122(9):3248-59. PubMed: 22863622 MGI: J:191299
Klein IK; Ritland SR; Burgart LJ; Ziesmer SC; Roche PC; Gendler SJ; Karnes WE Jr. 2000. Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice Cancer Res 60(8):2077-80. PubMed: 10786662 MGI: J:61731
Knutsen HK; Olstorn HB; Paulsen JE; Husoy T; Goverud IL; Loberg EM; Kristiansen K; Alexander J. 2005. Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice. Anticancer Res 25(6B):3781-9. PubMed: 16309164 MGI: J:106961
Koblansky AA; Truax AD; Liu R; Montgomery SA; Ding S; Wilson JE; Brickey WJ; Muhlbauer M; McFadden RM; Hu P; Li Z; Jobin C; Lund PK; Ting JP. 2016. The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals. Cell Rep 14(11):2562-75. PubMed: 26971998 MGI: J:234718
Koch S; Acebron SP; Herbst J; Hatiboglu G; Niehrs C. 2015. Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation. Cell 163(5):1225-36. PubMed: 26590424 MGI: J:228019
Koehl GE; Spitzner M; Ousingsawat J; Schreiber R; Geissler EK; Kunzelmann K. 2010. Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice. Oncogene 29(10):1553-60. PubMed: 19966863 MGI: J:160401
Koehler JA; Baggio LL; Yusta B; Longuet C; Rowland KJ; Cao X; Holland D; Brubaker PL; Drucker DJ. 2015. GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7. Cell Metab 21(3):379-91. PubMed: 25738454 MGI: J:220706
Koehler JA; Harper W; Barnard M; Yusta B; Drucker DJ. 2008. Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells. Cancer Res 68(19):7897-904. PubMed: 18829546 MGI: J:141821
Koh TJ; Bulitta CJ; Fleming JV; Dockray GJ; Varro A; Wang TC. 2000. Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. J Clin Invest 106(4):533-9. PubMed: 10953028 MGI: J:64625
Kohlhepp RL; Hegge LF; Moser AR. 2001. The ROSA26 LacZ-neoR insertion confers resistance to mammary tumors in ApcMin/+ mice. Mamm Genome 12(8):606-11. PubMed: 11471054 MGI: J:70825
Kohlhepp RL; Hegge LF; Nett JE; Moser AR. 2000. ROSA26 mice carry a modifier of Min-induced mammary and intestinal tumor development. Mamm Genome 11(12):1058-62. PubMed: 11130972 MGI: J:66060
Kohno M; Momoi M; Oo ML; Paik JH; Lee YM; Venkataraman K; Ai Y; Ristimaki AP; Fyrst H; Sano H; Rosenberg D; Saba JD; Proia RL; Hla T. 2006. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol 26(19):7211-23. PubMed: 16980623 MGI: J:112972
Kongkanuntn R; Bubb VJ; Sansom OJ; Wyllie AH; Harrison DJ; Clarke AR. 1999. Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice. Oncogene 18(51):7219-25. PubMed: 10602475 MGI: J:59017
Konsavage WM Jr; Yochum GS. 2014. The myc 3' wnt-responsive element suppresses colonic tumorigenesis. Mol Cell Biol 34(9):1659-69. PubMed: 24567369 MGI: J:213679
Koratkar R; Pequignot E; Hauck WW; Siracusa LD. 2002. The CAST/Ei strain confers significant protection against Apc(Min) intestinal polyps, independent of the resistant modifier of Min 1 (Mom1) locus. Cancer Res 62(19):5413-7. PubMed: 12359746 MGI: J:79690
Koratkar R; Silverman KA; Pequignot E; Hauck WW; Buchberg AM; Siracusa LD. 2004. Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to Apc(Min) intestinal tumorigenesis. Genomics 84(5):844-52. PubMed: 15475263 MGI: J:93365
Kozar S; Morrissey E; Nicholson AM; van der Heijden M; Zecchini HI; Kemp R; Tavare S; Vermeulen L; Winton DJ. 2013. Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas. Cell Stem Cell 13(5):626-33. PubMed: 24035355 MGI: J:202689
Kumar A; Pandurangan AK; Lu F; Fyrst H; Zhang M; Byun HS; Bittman R; Saba JD. 2012. Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3beta pathway in colon cancer. Carcinogenesis 33(9):1726-35. PubMed: 22581840 MGI: J:190770
Kundu P; Genander M; Straat K; Classon J; Ridgway RA; Tan EH; Bjork J; Martling A; van Es J; Sansom OJ; Clevers H; Pettersson S; Frisen J. 2015. An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Sci Transl Med 7(281):281ra44. PubMed: 25834110 MGI: J:234079
Kwong LN; Shedlovsky A; Biehl BS; Clipson L; Pasch CA; Dove WF. 2007. Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18. Genetics 176(2):1237-44. PubMed: 17435219 MGI: J:123865
Kwong LN; Weiss KR; Haigis KM; Dove WF. 2008. Atm is a negative regulator of intestinal neoplasia. Oncogene 27(7):1013-8. PubMed: 17700532 MGI: J:145250
Ladang A; Rapino F; Heukamp LC; Tharun L; Shostak K; Hermand D; Delaunay S; Klevernic I; Jiang Z; Jacques N; Jamart D; Migeot V; Florin A; Goktuna S; Malgrange B; Sansom OJ; Nguyen L; Buttner R; Close P; Chariot A. 2015. Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. J Exp Med 212(12):2057-75. PubMed: 26527802 MGI: J:227334
Laird PW; Jackson-Grusby L; Fazeli A; Dickinson SL; Jung WE; Li E; Weinberg RA; Jaenisch R. 1995. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 81(2):197-205. PubMed: 7537636 MGI: J:25691
Lal G; Ash C; Hay K; Redston M; Kwong E; Hancock B; Mak T; Kargman S; Evans JF; Gallinger S. 2001. Suppression of intestinal polyps in msh2-deficient and non-msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. Cancer Res 61(16):6131-6. PubMed: 11507063 MGI: J:70902
Lambert JD; Kwon SJ; Ju J; Bose M; Lee MJ; Hong J; Hao X; Yang CS. 2008. Effect of genistein on the bioavailability and intestinal cancer chemopreventive activity of (-)-epigallocatechin-3-gallate. Carcinogenesis 29(10):2019-24. PubMed: 18684728 MGI: J:140207
Lang J; Maeda Y; Bannerman P; Xu J; Horiuchi M; Pleasure D; Guo F. 2013. Adenomatous polyposis coli regulates oligodendroglial development. J Neurosci 33(7):3113-30. PubMed: 23407966 MGI: J:194259
Langlois MJ; Roy SA; Auclair BA; Jones C; Boudreau F; Carrier JC; Rivard N; Perreault N. 2009. Epithelial phosphatase and tensin homolog regulates intestinal architecture and secretory cell commitment and acts as a modifier gene in neoplasia. FASEB J 23(6):1835-44. PubMed: 19168705 MGI: J:150553
Larriba MJ; Ordonez-Moran P; Chicote I; Martin-Fernandez G; Puig I; Munoz A; Palmer HG. 2011. Vitamin D receptor deficiency enhances Wnt/beta-catenin signaling and tumor burden in colon cancer. PLoS One 6(8):e23524. PubMed: 21858154 MGI: J:178127
Lascano V; Zabalegui LF; Cameron K; Guadagnoli M; Jansen M; Burggraaf M; Versloot M; Rodermond H; van der Loos C; Carvalho-Pinto CE; Kalthoff H; Medema JP; Hahne M. 2012. The TNF family member APRIL promotes colorectal tumorigenesis. Cell Death Differ 19(11):1826-35. PubMed: 22705846 MGI: J:205474
Law DJ; Labut EM; Merchant JL. 2006. Intestinal overexpression of ZNF148 suppresses ApcMin/+ neoplasia. Mamm Genome 17(10):999-1004. PubMed: 17019648 MGI: J:115045
Lawrance AK; Deng L; Brody LC; Finnell RH; Shane B; Rozen R. 2007. Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apcmin/+ mice. J Nutr Biochem 18(5):305-12. PubMed: 16963246 MGI: J:121499
Leclerc D; Deng L; Trasler J; Rozen R. 2004. Apc(Min) (/+) mouse model of colon cancer: Gene expression profiling in tumors. J Cell Biochem 93(6):1242-1254. PubMed: 15486983 MGI: J:94113
Lee D; Pearsall RS; Das S; Dey SK; Godfrey VL; Threadgill DW. 2004. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Mol Cell Biol 24(20):8907-16. PubMed: 15456865 MGI: J:93327
Lee D; Yu M; Lee E; Kim H; Yang Y; Kim K; Pannicia C; Kurie JM; Threadgill DW. 2009. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. J Clin Invest 119(9):2702-13. PubMed: 19690388 MGI: J:152703
Lee J; Hargest R; Wasan H; Phillips RK. 2004. Liposome-mediated adenomatous polyposis coli gene therapy: a novel anti-adenoma strategy in multiple intestinal neoplasia mouse model. Dis Colon Rectum 47(12):2105-13. PubMed: 15657662 MGI: J:96281
Lee J; Kim JC; Lee SE; Quinley C; Kim H; Herdman S; Corr M; Raz E. 2012. Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability. J Biol Chem 287(22):18182-9. PubMed: 22496368 MGI: J:185613
Lee MN; Lee SN; Kim SH; Kim B; Jung BK; Seo JH; Park JH; Choi JH; Yim SH; Lee MR; Park JG; Yoo JY; Kim JH; Lee ST; Kim HM; Ryeom S; Kim KW; Oh GT. 2010. Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis. J Natl Cancer Inst 102(6):426-42. PubMed: 20194889 MGI: J:158746
Lee SH; Hu LL; Gonzalez-Navajas J; Seo GS; Shen C; Brick J; Herdman S; Varki N; Corr M; Lee J; Raz E. 2010. ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat Med 16(6):665-70. PubMed: 20473309 MGI: J:161529
Lee YS; Choi D; Kim NY; Yang S; Jung E; Hong M; Yang D; Lenz HJ; Hong YK. 2014. CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development. Int J Cancer 135(1):232-7. PubMed: 24338666 MGI: J:211966
Lefebvre AM; Chen I; Desreumaux P; Najib J; Fruchart JC; Geboes K; Briggs M; Heyman R; Auwerx J. 1998. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med 4(9):1053-7. PubMed: 9734399 MGI: J:49814
Leibowitz B; Qiu W; Buchanan ME; Zou F; Vernon P; Moyer MP; Yin XM; Schoen RE; Yu J; Zhang L. 2014. BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A 111(46):16520-5. PubMed: 25368155 MGI: J:216754
Leitges M. 2007. Functional PKC in vivo analysis using deficient mouse models. Biochem Soc Trans 35(Pt 5):1018-20. PubMed: 17956267 MGI: J:131178
Leung WH; Vong QP; Lin W; Janke L; Chen T; Leung W. 2013. Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation. J Exp Med 210(12):2675-92. PubMed: 24190430 MGI: J:207689
Levy DB; Smith KJ; Beazer-Barclay Y; Hamilton SR; Vogelstein B; Kinzler KW. 1994. Inactivation of both APC alleles in human and mouse tumors. Cancer Res 54(22):5953-8. PubMed: 7954428 MGI: J:21856
Leystra AA; Deming DA; Zahm CD; Farhoud M; Olson TJ; Hadac JN; Nettekoven LA; Albrecht DM; Clipson L; Sullivan R; Washington MK; Torrealba JR; Weichert JP; Halberg RB. 2012. Mice expressing activated PI3K rapidly develop advanced colon cancer. Cancer Res 72(12):2931-6. PubMed: 22525701 MGI: J:189325
Li B; Flaveny CA; Giambelli C; Fei DL; Han L; Hang BI; Bai F; Pei XH; Nose V; Burlingame O; Capobianco AJ; Orton D; Lee E; Robbins DJ. 2014. Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis. PLoS One 9(7):e101969. PubMed: 25003333 MGI: J:218924
Li J; Zhou Z; Zhang X; Zheng L; He D; Ye Y; Zhang QQ; Qi CL; He XD; Yu C; Shao CK; Qiao L; Wang L. 2017. Inflammatory Molecule, PSGL-1, Deficiency Activates Macrophages to Promote Colorectal Cancer Growth through NFkappaB Signaling. Mol Cancer Res 15(4):467-477. PubMed: 28108624 MGI: J:240407
Li M; Edamatsu H; Kitazawa R; Kitazawa S; Kataoka T. 2009. Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis. Carcinogenesis 30(8):1424-32. PubMed: 19458037 MGI: J:150971
Li N; Lee K; Xi Y; Zhu B; Gary BD; Ramirez-Alcantara V; Gurpinar E; Canzoneri JC; Fajardo A; Sigler S; Piazza JT; Chen X; Andrews J; Thomas M; Lu W; Li Y; Laan DJ; Moyer MP; Russo S; Eberhardt BT; Yet L; Keeton AB; Grizzle WE; Piazza GA. 2015. Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and beta-catenin-dependent TCF transcriptional activity. Oncogene 34(12):1499-509. PubMed: 24704829 MGI: J:221283
Li P; Schulz S; Bombonati A; Palazzo JP; Hyslop TM; Xu Y; Baran AA; Siracusa LD; Pitari GM; Waldman SA. 2007. Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology 133(2):599-607. PubMed: 17681179 MGI: J:126715
Li Q; Lohr CV; Dashwood RH. 2009. Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse. Cancer Lett 283(1):36-42. PubMed: 19376641 MGI: J:150872
Li X; Stevens PD; Liu J; Yang H; Wang W; Wang C; Zeng Z; Schmidt MD; Yang M; Lee EY; Gao T. 2014. PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice. Gastroenterology 146(5):1301-12.e1-10. PubMed: 24530606 MGI: J:225239
Li Y; Bavarva JH; Wang Z; Guo J; Qian C; Thibodeau SN; Golemis EA; Liu W. 2011. HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression. Oncogene 30(23):2633-43. PubMed: 21317929 MGI: J:173694
Li Y; Kundu P; Seow SW; de Matos CT; Aronsson L; Chin KC; Karre K; Pettersson S; Greicius G. 2012. Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice. Carcinogenesis 33(6):1231-8. PubMed: 22461519 MGI: J:189340
Li Y; Teo WL; Low MJ; Meijer L; Sanderson I; Pettersson S; Greicius G. 2014. Constitutive TLR4 signalling in intestinal epithelium reduces tumor load by increasing apoptosis in APC(Min/+) mice. Oncogene 33(3):369-77. PubMed: 23318418 MGI: J:204878
Liddle FJ; Frank DA. 2008. STAT1 expression is not required for polyp formation in Min mice. Mol Carcinog 47(2):75-9. PubMed: 17683066 MGI: J:129797
Lim SK; Kim H; Lim SK; bin Ali A; Lim YK; Wang Y; Chong SM; Costantini F; Baumman H. 1998. Increased susceptibility in Hp knockout mice during acute hemolysis. Blood 92(6):1870-7. PubMed: 9731043 MGI: J:49888
Lin H; Yamada Y; Nguyen S; Linhart H; Jackson-Grusby L; Meissner A; Meletis K; Lo G; Jaenisch R. 2006. Suppression of intestinal neoplasia by deletion of Dnmt3b. Mol Cell Biol 26(8):2976-83. PubMed: 16581773 MGI: J:107386
Lin S; Lee SJ; Shim H; Chun J; Yun CC. 2010. The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine. Am J Physiol Gastrointest Liver Physiol 299(5):G1128-38. PubMed: 20724530 MGI: J:165823
Lin S; Wang D; Iyer S; Ghaleb AM; Shim H; Yang VW; Chun J; Yun CC. 2009. The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer. Gastroenterology 136(5):1711-20. PubMed: 19328876 MGI: J:148510
Linhart HG; Lin H; Yamada Y; Moran E; Steine EJ; Gokhale S; Lo G; Cantu E; Ehrich M; He T; Meissner A; Jaenisch R. 2007. Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev 21(23):3110-22. PubMed: 18056424 MGI: J:127808
Lissa D; Senovilla L; Rello-Varona S; Vitale I; Michaud M; Pietrocola F; Boileve A; Obrist F; Bordenave C; Garcia P; Michels J; Jemaa M; Kepp O; Castedo M; Kroemer G. 2014. Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention. Proc Natl Acad Sci U S A 111(8):3020-5. PubMed: 24516128 MGI: J:206824
Liu HP; Gao ZH; Cui SX; Wang Y; Li BY; Lou HX; Qu XJ. 2013. Chemoprevention of intestinal adenomatous polyposis by acetyl-11-keto-beta-boswellic acid in APC(Min/+) mice. Int J Cancer 132(11):2667-81. PubMed: 23132636 MGI: J:197222
Liu P; Lu Y; Liu H; Wen W; Jia D; Wang Y; You M. 2012. Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice. Mol Cancer Res 10(1):66-74. PubMed: 22127497 MGI: J:205396
Liu S; Qian Y; Li L; Wei G; Guan Y; Pan H; Guan X; Zhang L; Lu X; Zhao Y; Liu M; Li D. 2013. Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice. J Biol Chem 288(13):8794-803; discussion 8804. PubMed: 23393138 MGI: J:197850
Liu S; Tackmann NR; Yang J; Zhang Y. 2016. Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis. Oncogene :. PubMed: 27617574 MGI: J:236456
Liu W; Li H; Hong SH; Piszczek GP; Chen W; Rodgers GP. 2016. Olfactomedin 4 deletion induces colon adenocarcinoma in Apc mice. Oncogene :. PubMed: 26973250 MGI: J:230791
Liu Z; Xiao Y; Zhou Z; Mao X; Cai J; Xiong L; Liao C; Huang F; Liu Z; Ali Sheikh MS; Plutzky J; Huang H; Yang T; Duan Q. 2016. Extensive metabolic disorders are present in APC(min) tumorigenesis mice. Mol Cell Endocrinol 427:57-64. PubMed: 26948948 MGI: J:241184
Lochner M; Peduto L; Cherrier M; Sawa S; Langa F; Varona R; Riethmacher D; Si-Tahar M; Di Santo JP; Eberl G. 2008. In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med 205(6):1381-93. PubMed: 18504307 MGI: J:137020
Lojda Z; Havrankova E; Sovova V; Sloncova E; Fric P. 1999. Are intestinal tumours in Apc+/-mice a suitable model of colorectal carcinoma in man? Gen Physiol Biophys 18(3):311-6. PubMed: 10703747 MGI: J:61219
Luo F; Brooks DG; Ye H; Hamoudi R; Poulogiannis G; Patek CE; Winton DJ; Arends MJ. 2009. Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways. Int J Exp Pathol 90(5):558-74. PubMed: 19765110 MGI: J:154716
Luo F; Poulogiannis G; Ye H; Hamoudi R; Arends MJ. 2011. Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis. Oncol Rep 26(1):125-33. PubMed: 21573497 MGI: J:196047
Luo G; Santoro IM; McDaniel LD; Nishijima I; Mills M; Youssoufian H; Vogel H; Schultz RA; Bradley A. 2000. Cancer predisposition caused by elevated mitotic recombination in bloom mice Nat Genet 26(4):424-9. PubMed: 11101838 MGI: J:66261
Luongo C; Dove WF. 1996. Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse. Genes Chromosomes Cancer 17(3):194-8. PubMed: 8946200 MGI: J:37497
Luongo C; Moser AR; Gledhill S; Dove WF. 1994. Loss of Apc+ in intestinal adenomas from Min mice. Cancer Res 54(22):5947-52. PubMed: 7954427 MGI: J:21369
Lustig B; Jerchow B; Sachs M; Weiler S; Pietsch T; Karsten U; van de Wetering M; Clevers H; Schlag PM; Birchmeier W; Behrens J. 2002. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 22(4):1184-93. PubMed: 11809809 MGI: J:74286
Ma L; Tao Y; Duran A; Llado V; Galvez A; Barger JF; Castilla EA; Chen J; Yajima T; Porollo A; Medvedovic M; Brill LM; Plas DR; Riedl SJ; Leitges M; Diaz-Meco MT; Richardson AD; Moscat J. 2013. Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCzeta in Tumorigenesis. Cell 152(3):599-611. PubMed: 23374352 MGI: J:193453
Mabley JG; Pacher P; Bai P; Wallace R; Goonesekera S; Virag L; Southan GJ; Szabo C. 2004. Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways. Mutat Res 548(1-2):107-16. PubMed: 15063141 MGI: J:89155
MacPhee M; Chepenik KP; Liddell RA; Nelson KK; Siracusa LD; Buchberg AM. 1995. The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia. Cell 81(6):957-66. PubMed: 7781071 MGI: J:26137
Macfarlane AJ; Perry CA; McEntee MF; Lin DM; Stover PJ. 2011. Mthfd1 is a modifier of chemically induced intestinal carcinogenesis. Carcinogenesis 32(3):427-33. PubMed: 21156972 MGI: J:169323
Macfarlane AJ; Perry CA; McEntee MF; Lin DM; Stover PJ. 2011. Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of apcmin-mediated intestinal cancer risk. Cancer Res 71(6):2098-107. PubMed: 21406397 MGI: J:169921
Maeda S; Hikiba Y; Shibata W; Ohmae T; Yanai A; Ogura K; Yamada S; Omata M. 2007. Essential roles of high-mobility group box 1 in the development of murine colitis and colitis-associated cancer. Biochem Biophys Res Commun 360(2):394-400. PubMed: 17599806 MGI: J:123028
Mahmoud NN; Boolbol SK; Dannenberg AJ; Mestre JR; Bilinski RT; Martucci C; Newmark HL; Chadburn A; Bertagnolli MM. 1998. The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis. Carcinogenesis 19(1):87-91. PubMed: 9472698 MGI: J:45638
Mahmoud NN; Carothers AM; Grunberger D; Bilinski RT; Churchill MR; Martucci C; Newmark HL; Bertagnolli MM. 2000. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Carcinogenesis 21(5):921-7. PubMed: 10783313 MGI: J:61979
Mahmoud NN; Dannenberg AJ; Bilinski RT; Mestre JR; Chadburn A; Churchill M; Martucci C; Bertagnolli MM. 1999. Administration of an unconjugated bile acid increases duodenal tumors in a murine model of familial adenomatous polyposis. Carcinogenesis 20(2):299-303. PubMed: 10069468 MGI: J:53701
Mahmoud NN; Dannenberg AJ; Mestre J; Bilinski RT; Churchill MR; Martucci C; Newmark H; Bertagnolli MM. 1998. Aspirin prevents tumors in a murine model of familial adenomatous polyposis. Surgery 124(2):225-31. PubMed: 9706142 MGI: J:50316
Mai V; Colbert LH; Berrigan D; Perkins SN; Pfeiffer R; Lavigne JA; Lanza E; Haines DC; Schatzkin A; Hursting SD. 2003. Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms. Cancer Res 63(8):1752-5. PubMed: 12702556 MGI: J:82980
Mai V; Colbert LH; Perkins SN; Schatzkin A; Hursting SD. 2007. Intestinal microbiota: a potential diet-responsive prevention target in ApcMin mice. Mol Carcinog 46(1):42-8. PubMed: 16929480 MGI: J:118047
Malaterre J; Pereira L; Putoczki T; Millen R; Paquet-Fifield S; Germann M; Liu J; Cheasley D; Sampurno S; Stacker SA; Achen MG; Ward RL; Waring P; Mantamadiotis T; Ernst M; Ramsay RG. 2016. Intestinal-specific activatable Myb initiates colon tumorigenesis in mice. Oncogene 35(19):2475-84. PubMed: 26300002 MGI: J:234207
Malliri A; Rygiel TP; van der Kammen RA; Song JY; Engers R; Hurlstone AF; Clevers H; Collard JG. 2006. The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem 281(1):543-8. PubMed: 16249175 MGI: J:105716
Mann EA; Steinbrecher KA; Stroup C; Witte DP; Cohen MB; Giannella RA. 2005. Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model. Int J Cancer 116(4):500-5. PubMed: 15825168 MGI: J:99670
Mann MB; Hodges CA; Barnes E; Vogel H; Hassold TJ; Luo G. 2005. Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome. Hum Mol Genet 14(6):813-25. PubMed: 15703196 MGI: J:97101
March HN; Rust AG; Wright NA; Ten Hoeve J; de Ridder J; Eldridge M; van der Weyden L; Berns A; Gadiot J; Uren A; Kemp R; Arends MJ; Wessels LF; Winton DJ; Adams DJ. 2011. Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat Genet 43(12):1202-9. PubMed: 22057237 MGI: J:178629
Maretto S; Cordenonsi M; Dupont S; Braghetta P; Broccoli V; Hassan AB; Volpin D; Bressan GM; Piccolo S. 2003. Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A 100(6):3299-304. PubMed: 12626757 MGI: J:82727
Martinez C; Bhattacharya S; Freeman T; Churchman M; Ilyas M. 2005. Expression profiling of murine intestinal adenomas reveals early deregulation of multiple matrix metalloproteinase (Mmp) genes. J Pathol 206(1):100-10. PubMed: 15809971 MGI: J:97518
May R; Riehl TE; Hunt C; Sureban SM; Anant S; Houchen CW. 2008. Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells 26(3):630-7. PubMed: 18055444 MGI: J:145391
Maywald RL; Doerner SK; Pastorelli L; De Salvo C; Benton SM; Dawson EP; Lanza DG; Berger NA; Markowitz SD; Lenz HJ; Nadeau JH; Pizarro TT; Heaney JD. 2015. IL-33 activates tumor stroma to promote intestinal polyposis. Proc Natl Acad Sci U S A 112(19):E2487-96. PubMed: 25918379 MGI: J:221412
Mazzolini R; Dopeso H; Mateo-Lozano S; Chang W; Rodrigues P; Bazzocco S; Alazzouzi H; Landolfi S; Hernandez-Losa J; Andretta E; Alhopuro P; Espin E; Armengol M; Tabernero J; Ramon y Cajal S; Kloor M; Gebert J; Mariadason JM; Schwartz S Jr; Aaltonen LA; Mooseker MS; Arango D. 2012. Brush border myosin Ia has tumor suppressor activity in the intestine. Proc Natl Acad Sci U S A 109(5):1530-5. PubMed: 22307608 MGI: J:181908
McCart AE; Vickaryous NK; Silver A. 2008. Apc mice: models, modifiers and mutants. Pathol Res Pract 204(7):479-90. PubMed: 18538487 MGI: J:139896
McCleland ML; Soukup TM; Liu SD; Esensten JH; de Sousa E Melo F; Yaylaoglu M; Warming S; Roose-Girma M; Firestein R. 2015. Cdk8 deletion in the Apc murine tumour model represses EZH2 activity and accelerates tumourigenesis. J Pathol :. PubMed: 26235356 MGI: J:227730
McClellan JL; Davis JM; Steiner JL; Enos RT; Jung SH; Carson JA; Pena MM; Carnevale KA; Berger FG; Murphy EA. 2012. Linking tumor-associated macrophages, inflammation, and intestinal tumorigenesis: role of MCP-1. Am J Physiol Gastrointest Liver Physiol 303(10):G1087-95. PubMed: 23019193 MGI: J:193658
McConnell BB; Bialkowska AB; Nandan MO; Ghaleb AM; Gordon FJ; Yang VW. 2009. Haploinsufficiency of Kruppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine. Cancer Res 69(10):4125-33. PubMed: 19435907 MGI: J:148473
McNally JB; Kirkpatrick ND; Hariri LP; Tumlinson AR; Besselsen DG; Gerner EW; Utzinger U; Barton JK. 2006. Task-based imaging of colon cancer in the Apc(Min/+) mouse model. Appl Opt 45(13):3049-62. PubMed: 16639453 MGI: J:115845
Meira LB; Bugni JM; Green SL; Lee CW; Pang B; Borenshtein D; Rickman BH; Rogers AB; Moroski-Erkul CA; McFaline JL; Schauer DB; Dedon PC; Fox JG; Samson LD. 2008. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest 118(7):2516-25. PubMed: 18521188 MGI: J:137708
Meniel V; Song F; Phesse T; Young M; Poetz O; Parry L; Jenkins JR; Williams GT; Dunwoodie SL; Watson A; Clarke AR. 2013. Cited1 deficiency suppresses intestinal tumorigenesis. PLoS Genet 9(8):e1003638. PubMed: 23935526 MGI: J:200592
Merritt AJ; Gould KA; Dove WF. 1997. Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages. Proc Natl Acad Sci U S A 94(25):13927-31. PubMed: 9391129 MGI: J:44639
Metcalfe C; Ibrahim AE; Graeb M; de la Roche M; Schwarz-Romond T; Fiedler M; Winton DJ; Corfield A; Bienz M. 2010. Dvl2 Promotes Intestinal Length and Neoplasia in the ApcMin Mouse Model for Colorectal Cancer. Cancer Res 70(16):6629-38. PubMed: 20663899 MGI: J:162767
Millar CB; Guy J; Sansom OJ; Selfridge J; MacDougall E; Hendrich B; Keightley PD; Bishop SM; Clarke AR; Bird A. 2002. Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science 297(5580):403-5. PubMed: 12130785 MGI: J:77896
Mimura M; Masuda A; Nishiumi S; Kawakami K; Fujishima Y; Yoshie T; Mizuno S; Miki I; Ohno H; Hase K; Minamoto T; Azuma T; Yoshida M. 2012. AP1B plays an important role in intestinal tumorigenesis with the truncating mutation of an APC gene. Int J Cancer 130(5):1011-20. PubMed: 21484796 MGI: J:181081
Misikangas M; Pajari AM; Paivarinta E; Oikarinen SI; Rajakangas J; Marttinen M; Tanayama H; Torronen R; Mutanen M. 2007. Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinal neoplasia/+ mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa. J Nutr 137(10):2285-90. PubMed: 17885012 MGI: J:129387
Misikangas M; Tanayama H; Rajakangas J; Linden J; Pajari AM; Mutanen M. 2008. Inulin results in increased levels of beta-catenin and cyclin D1 as the adenomas increase in size from small to large in the Min/+ mouse. Br J Nutr 99(5):963-70. PubMed: 17977470 MGI: J:133547
Misiorek JO; Lahdeniemi IA; Nystrom JH; Paramonov VM; Gullmets JA; Saarento H; Rivero-Muller A; Husoy T; Taimen P; Toivola DM. 2016. Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway. Carcinogenesis 37(8):777-86. PubMed: 27234655 MGI: J:233955
Miyamoto S; Yasui Y; Tanaka T; Ohigashi H; Murakami A. 2008. Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice. Carcinogenesis 29(5):1057-63. PubMed: 18375960 MGI: J:138519
Mochida Y; Taguchi K; Taniguchi S; Tsuneyoshi M; Kuwano H; Tsuzuki T; Kuwano M; Wada M. 2003. The role of P-glycoprotein in intestinal tumorigenesis: disruption of mdr1a suppresses polyp formation in Apc(Min/+) mice. Carcinogenesis 24(7):1219-24. PubMed: 12807720 MGI: J:84491
Modica S; Murzilli S; Salvatore L; Schmidt DR; Moschetta A. 2008. Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. Cancer Res 68(23):9589-94. PubMed: 19047134 MGI: J:142094
Mohammed Abdul KS; Jovanovic S; Du Q; Sukhodub A; Jovanovic A. 2015. Mild hypoxia in vivo regulates cardioprotective SUR2A: A role for Akt and LDH. Biochim Biophys Acta 1852(5):709-19. PubMed: 25576887 MGI: J:234539
Mollersen L; Paulsen JE; Olstorn HB; Knutsen HK; Alexander J. 2004. Dietary retinoic acid supplementation stimulates intestinal tumour formation and growth in multiple intestinal neoplasia (Min)/+ mice. Carcinogenesis 25(1):149-53. PubMed: 14514656 MGI: J:87705
Mollersen L; Vikse R; Andreassen A; Steffensen IL; Mikalsen A; Paulsen JE; Alexander J. 2004. Adenomatous polyposis coli truncation mutations in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumours of multiple intestinal neoplasia mice. Mutat Res 557(1):29-40. PubMed: 14706516 MGI: J:87470
Moon BS; Jeong WJ; Park J; Kim TI; Min do S; Choi KY. 2014. Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/beta-catenin signaling. J Natl Cancer Inst 106(2):djt373. PubMed: 24491301 MGI: J:208322
Moran AE; Hunt DH; Javid SH; Redston M; Carothers AM; Bertagnolli MM. 2004. Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice. J Biol Chem 279(41):43261-72. PubMed: 15294912 MGI: J:94014
Moser AR; Dove WF; Roth KA; Gordon JI. 1992. The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J Cell Biol 116(6):1517-26. PubMed: 1541640 MGI: J:1879
Moser AR; Hegge LF; Cardiff RD. 2001. Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice. Cancer Res 61(8):3480-5. PubMed: 11309311 MGI: J:68915
Moser AR; Luongo C; Gould KA; McNeley MK; Shoemaker AR; Dove WF. 1995. ApcMin: a mouse model for intestinal and mammary tumorigenesis. Eur J Cancer 31A(7-8):1061-4. PubMed: 7576992 MGI: J:28572
Moser AR; Mattes EM; Dove WF; Lindstrom MJ; Haag JD; Gould MN. 1993. ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias. Proc Natl Acad Sci U S A 90(19):8977-81. PubMed: 8415640 MGI: J:15101
Moser AR; Shoemaker AR; Connelly CS; Clipson L; Gould KA; Luongo C; Dove WF; Siggers PH; Gardner RL. 1995. Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation. Dev Dyn 203(4):422-33. PubMed: 7496034 MGI: J:27993
Muller-Decker K; Furstenberger G. 2007. The cyclooxygenase-2-mediated prostaglandin signaling is causally related to epithelial carcinogenesis. Mol Carcinog 46(8):705-10. PubMed: 17546626 MGI: J:126154
Murray NR; Weems J; Braun U; Leitges M; Fields AP. 2009. Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression. Cancer Res 69(2):656-62. PubMed: 19147581 MGI: J:143707
Mutanen M; Pajari AM; Oikarinen SI. 2000. Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymes. Carcinogenesis 21(6):1167-73. PubMed: 10837006 MGI: J:62978
Mutoh H; Sakurai S; Satoh K; Tamada K; Kita H; Osawa H; Tomiyama T; Sato Y; Yamamoto H; Isoda N; Yoshida T; Ido K; Sugano K. 2004. Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice. Cancer Res 64(21):7740-7. PubMed: 15520178 MGI: J:93806
Mutoh M; Komiya M; Teraoka N; Ueno T; Takahashi M; Kitahashi T; Sugimura T; Wakabayashi K. 2009. Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice. Int J Cancer 125(11):2505-10. PubMed: 19544529 MGI: J:153919
Mutoh M; Niho N; Komiya M; Takahashi M; Ohtsubo R; Nakatogawa K; Ueda K; Sugimura T; Wakabayashi K. 2008. Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice. Carcinogenesis 29(4):824-9. PubMed: 18258607 MGI: J:133497
Mutoh M; Watanabe K; Kitamura T; Shoji Y; Takahashi M; Kawamori T; Tani K; Kobayashi M; Maruyama T; Kobayashi K; Ohuchida S; Sugimoto Y; Narumiya S; Sugimura T; Wakabayashi K. 2002. Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. Cancer Res 62(1):28-32. PubMed: 11782353 MGI: J:73944
Myung SJ; Rerko RM; Yan M; Platzer P; Guda K; Dotson A; Lawrence E; Dannenberg AJ; Lovgren AK; Luo G; Pretlow TP; Newman RA; Willis J; Dawson D; Markowitz SD. 2006. 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Proc Natl Acad Sci U S A 103(32):12098-102. PubMed: 16880406 MGI: J:111783
Myzak MC; Dashwood WM; Orner GA; Ho E; Dashwood RH. 2006. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J 20(3):506-8. PubMed: 16407454 MGI: J:107343
Nadeau JH. 2001. Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74. PubMed: 11256068 MGI: J:88013
Nadeau JH. 2003. Modifier genes and protective alleles in humans and mice. Curr Opin Genet Dev 13(3):290-5. PubMed: 12787792 MGI: J:88012
Nagamine CM; Sohn JJ; Rickman BH; Rogers AB; Fox JG; Schauer DB. 2008. Helicobacter hepaticus infection promotes colon tumorigenesis in the BALB/c-Rag2(-/-) Apc(Min/+) mouse. Infect Immun 76(6):2758-66. PubMed: 18411292 MGI: J:136281
Nagel JM; Geiger BM; Karagiannis AK; Gras-Miralles B; Horst D; Najarian RM; Ziogas DC; Chen X; Kokkotou E. 2012. Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone. PLoS One 7(7):e41914. PubMed: 22848656 MGI: J:189691
Naigamwalla D; Chia MC; Tran TT; Medline A; Hay K; Gallinger S; Bruce WR. 2000. Polyethylene glycol 8000 and colon carcinogenesis: inhibition in the F344 rat, promotion in the Min mouse. Cancer Res 60(24):6856-8. PubMed: 11156379 MGI: J:66914
Nakanishi Y; Nakatsuji M; Seno H; Ishizu S; Akitake-Kawano R; Kanda K; Ueo T; Komekado H; Kawada M; Minami M; Chiba T. 2011. COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps. Carcinogenesis 32(9):1333-9. PubMed: 21730361 MGI: J:175555
Nakanishi Y; Seno H; Fukuoka A; Ueo T; Yamaga Y; Maruno T; Nakanishi N; Kanda K; Komekado H; Kawada M; Isomura A; Kawada K; Sakai Y; Yanagita M; Kageyama R; Kawaguchi Y; Taketo MM; Yonehara S; Chiba T. 2013. Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet 45(1):98-103. PubMed: 23202126 MGI: J:193873
Nakatsugi S; Fukutake M; Takahashi M; Fukuda K; Isoi T; Taniguchi Y; Sugimura T; Wakabayashi K. 1997. Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice Jpn J Cancer Res 88(12):1117-20. PubMed: 9473726 MGI: J:45606
Nam HJ; van Deursen JM. 2014. Cyclin B2 and p53 control proper timing of centrosome separation. Nat Cell Biol 16(6):538-49. PubMed: 24776885 MGI: J:219399
Nam KT; Lee HJ; Smith JJ; Lapierre LA; Kamath VP; Chen X; Aronow BJ; Yeatman TJ; Bhartur SG; Calhoun BC; Condie B; Manley NR; Beauchamp RD; Coffey RJ; Goldenring JR. 2010. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest 120(3):840-9. PubMed: 20197623 MGI: J:158733
Nandi B; Pai C; Huang Q; Prabhala RH; Munshi NC; Gold JS. 2014. CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis. PLoS One 9(5):e97566. PubMed: 24866282 MGI: J:216494
Narsale AA; Enos RT; Puppa MJ; Chatterjee S; Murphy EA; Fayad R; Pena MO; Durstine JL; Carson JA. 2015. Liver inflammation and metabolic signaling in ApcMin/+ mice: the role of cachexia progression. PLoS One 10(3):e0119888. PubMed: 25789991 MGI: J:229200
Nateri AS; Spencer-Dene B; Behrens A. 2005. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437(7056):281-5. PubMed: 16007074 MGI: J:101496
Naumov I; Zilberberg A; Shapira S; Avivi D; Kazanov D; Rosin-Arbesfeld R; Arber N; Kraus S. 2014. CD24 knockout prevents colorectal cancer in chemically induced colon carcinogenesis and in APC(Min)/CD24 double knockout transgenic mice. Int J Cancer 135(5):1048-59. PubMed: 24500912 MGI: J:212998
Nautiyal J; Banerjee S; Kanwar SS; Yu Y; Patel BB; Sarkar FH; Majumdar AP. 2011. Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells. Int J Cancer 128(4):951-61. PubMed: 20473900 MGI: J:167346
Necela BM; Carr JM; Asmann YW; Thompson EA. 2011. Differential Expression of MicroRNAs in Tumors from Chronically Inflamed or Genetic (APC) Models of Colon Cancer. PLoS One 6(4):e18501. PubMed: 21532750 MGI: J:172401
Neufert C; Becker C; Tureci O; Waldner MJ; Backert I; Floh K; Atreya I; Leppkes M; Jefremow A; Vieth M; Schneider-Stock R; Klinger P; Greten FR; Threadgill DW; Sahin U; Neurath MF. 2013. Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK. J Clin Invest 123(4):1428-43. PubMed: 23549083 MGI: J:197608
Newman JV; Kosaka T; Sheppard BJ; Fox JG; Schauer DB. 2001. Bacterial infection promotes colon tumorigenesis in apcmin/+ mice. J Infect Dis 184(2):227-30. PubMed: 11424022 MGI: J:70382
Newton VA; Ramocki NM; Scull BP; Simmons JG; McNaughton K; Lund PK. 2010. Suppressor of cytokine signaling-2 gene disruption promotes Apc(Min/+) tumorigenesis and activator protein-1 activation. Am J Pathol 176(5):2320-32. PubMed: 20348236 MGI: J:160765
Nguyen HT; Dalmasso G; Yan Y; Laroui H; Charania M; Ingersoll S; Ayyadurai S; Zhang Y; Sitaraman S; Merlin D. 2012. Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in Apc(Min/+) mice. Lab Invest 92(8):1203-12. PubMed: 22641098 MGI: J:186835
Niederreiter L; Fritz TM; Adolph TE; Krismer AM; Offner FA; Tschurtschenthaler M; Flak MB; Hosomi S; Tomczak MF; Kaneider NC; Sarcevic E; Kempster SL; Raine T; Esser D; Rosenstiel P; Kohno K; Iwawaki T; Tilg H; Blumberg RS; Kaser A. 2013. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells. J Exp Med 210(10):2041-56. PubMed: 24043762 MGI: J:204069
Niho N; Mutoh M; Takahashi M; Tsutsumi K; Sugimura T; Wakabayashi K. 2005. Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice. Proc Natl Acad Sci U S A 102(8):2970-4. PubMed: 15710887 MGI: J:96832
Niho N; Takahashi M; Kitamura T; Shoji Y; Itoh M; Noda T; Sugimura T; Wakabayashi K. 2003. Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Cancer Res 63(18):6090-5. PubMed: 14522940 MGI: J:86036
Nilsson LM; Forshell TZ; Rimpi S; Kreutzer C; Pretsch W; Bornkamm GW; Nilsson JA. 2012. Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis. PLoS Genet 8(3):e1002573. PubMed: 22438825 MGI: J:183477
Nishiumi S; Fujishima Y; Inoue J; Masuda A; Azuma T; Yoshida M. 2012. Autophagy in the intestinal epithelium is not involved in the pathogenesis of intestinal tumors. Biochem Biophys Res Commun 421(4):768-72. PubMed: 22546555 MGI: J:184527
Novelli MR; Wasan H; Rosewell I; Bee J; Tomlinson IP; Wright NA; Bodmer WF. 1999. Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras. Proc Natl Acad Sci U S A 96(22):12553-8. PubMed: 10535960 MGI: J:59511
Oghamian S; Sodir NM; Bashir MU; Shen H; Cullins AE; Carroll CA; Kundu P; Shibata D; Laird PW. 2011. Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice. Carcinogenesis 32(6):829-35. PubMed: 21362628 MGI: J:172257
Oikarinen S; Heinonen S; Karppinen S; Matto J; Adlercreutz H; Poutanen K; Mutanen M. 2003. Plasma enterolactone or intestinal Bifidobacterium levels do not explain adenoma formation in multiple intestinal neoplasia (Min) mice fed with two different types of rye-bran fractions. Br J Nutr 90(1):119-25. PubMed: 12844383 MGI: J:85024
Oikarinen SI; Cleveland AG; Cork KM; Bynote KK; Rafter JJ; Gustafsson JA; Mutanen M; Gould KA. 2009. Genetic mapping of Mom5, a novel modifier of Apc(Min)-induced intestinal tumorigenesis. Carcinogenesis 30(9):1591-6. PubMed: 19574546 MGI: J:152194
Okamoto M; Yonekawa H. 2005. Intestinal tumorigenesis in Min mice is enhanced by X-irradiation in an age-dependent manner. J Radiat Res (Tokyo) 46(1):83-91. PubMed: 15802863 MGI: J:98670
Ordonez-Moran P; Dafflon C; Imajo M; Nishida E; Huelsken J. 2015. HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer. Cancer Cell 28(6):815-29. PubMed: 26678341 MGI: J:227407
Oskouian B; Sooriyakumaran P; Borowsky AD; Crans A; Dillard-Telm L; Tam YY; Bandhuvula P; Saba JD. 2006. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci U S A 103(46):17384-9. PubMed: 17090686 MGI: J:117131
Oster H; Leitges M. 2006. Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice. Cancer Res 66(14):6955-63. PubMed: 16849539 MGI: J:112117
Otani K; Kitayama J; Yasuda K; Nio Y; Iwabu M; Okudaira S; Aoki J; Yamauchi T; Kadowaki T; Nagawa H. 2010. Adiponectin suppresses tumorigenesis in Apc(Min)(/+) mice. Cancer Lett 288(2):177-82. PubMed: 19646806 MGI: J:156656
Ou J; Miao H; Ma Y; Guo F; Deng J; Wei X; Zhou J; Xie G; Shi H; Xue B; Liang H; Yu L. 2014. Loss of abhd5 promotes colorectal tumor development and progression by inducing aerobic glycolysis and epithelial-mesenchymal transition. Cell Rep 9(5):1798-811. PubMed: 25482557 MGI: J:222179
Oudhoff MJ; Braam MJ; Freeman SA; Wong D; Rattray DG; Wang J; Antignano F; Snyder K; Refaeli I; Hughes MR; McNagny KM; Gold MR; Arrowsmith CH; Sato T; Rossi FM; Tatlock JH; Owen DR; Brown PJ; Zaph C. 2016. SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/beta-Catenin and Hippo/YAP Signaling. Dev Cell 37(1):47-57. PubMed: 27046831 MGI: J:240229
Ouyang N; Williams JL; Rigas B. 2006. NO-donating aspirin isomers downregulate peroxisome proliferator-activated receptor (PPAR)delta expression in APC(min/+) mice proportionally to their tumor inhibitory effect: Implications for the role of PPARdelta in carcinogenesis. Carcinogenesis 27(2):232-9. PubMed: 16141240 MGI: J:105102
Oyama T; Yamada Y; Hata K; Tomita H; Hirata A; Sheng H; Hara A; Aoki H; Kunisada T; Yamashita S; Mori H. 2008. Further upregulation of beta-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice. Carcinogenesis 29(3):666-72. PubMed: 18204079 MGI: J:133438
Pajari AM; Smeds AI; Oikarinen SI; Eklund PC; Sjoholm RE; Mutanen M. 2006. The plant lignans matairesinol and secoisolariciresinol administered to Min mice do not protect against intestinal tumor formation. Cancer Lett 233(2):309-14. PubMed: 16000235 MGI: J:106323
Pan P; Skaer CW; Wang HT; Stirdivant SM; Young MR; Oshima K; Stoner GD; Lechner JF; Huang YW; Wang LS. 2015. Black raspberries suppress colonic adenoma development in ApcMin/+ mice: relation to metabolite profiles. Carcinogenesis 36(10):1245-53. PubMed: 26246425 MGI: J:225873
Pan P; W Skaer C; Wang HT; Oshima K; Huang YW; Yu J; Zhang J; M Yearsley M; A Agle K; R Drobyski W; Chen X; Wang LS. 2017. Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice. Carcinogenesis 38(1):86-93. PubMed: 27866157 MGI: J:237984
Paoni NF; Feldman MW; Gutierrez LS; Ploplis VA; Castellino FJ. 2003. Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse. Physiol Genomics 15(3):228-35. PubMed: 13130079 MGI: J:86113
Park JM; Kanaoka Y; Eguchi N; Aritake K; Grujic S; Materi AM; Buslon VS; Tippin BL; Kwong AM; Salido E; French SW; Urade Y; Lin HJ. 2007. Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. Cancer Res 67(3):881-9. PubMed: 17283118 MGI: J:118232
Parsons-Wingerter P; Kasman IM; Norberg S; Magnussen A; Zanivan S; Rissone A; Baluk P; Favre CJ; Jeffry U; Murray R; McDonald DM. 2005. Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors. Am J Pathol 167(1):193-211. PubMed: 15972964 MGI: J:99505
Patek CE; Arends MJ; Rose L; Luo F; Walker M; Devenney PS; Berry RL; Lawrence NJ; Ridgway RA; Sansom OJ; Hooper ML. 2008. The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine. BMC Gastroenterol 8:24. PubMed: 18554389 MGI: J:139887
Paulsen JE; Alexander J. 2001. Growth stimulation of intestinal tumours in Apc(Min/+) mice by dietary L-methionine supplementation. Anticancer Res 21(5):3281-4. PubMed: 11848484 MGI: J:75262
Paulsen JE; Elvsaas IK; Steffensen IL; Alexander J. 1997. A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse. Carcinogenesis 18(10):1905-10. PubMed: 9363998 MGI: J:45978
Paulsen JE; Namork E; Steffensen IL; Eide TJ; Alexander J. 2000. Identification and quantification of aberrant crypt foci in the colon of Min mice--a murine model of familial adenomatous polyposis Scand J Gastroenterol 35(5):534-9. PubMed: 10868458 MGI: J:62966
Paulsen JE; Steffensen IL; Andreassen A; Vikse R; Alexander J. 1999. Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice. Carcinogenesis 20(7):1277-82. PubMed: 10383901 MGI: J:56392
Peregrina K; Houston M; Daroqui C; Dhima E; Sellers RS; Augenlicht LH. 2015. Vitamin D is a determinant of mouse intestinal Lgr5 stem cell functions. Carcinogenesis 36(1):25-31. PubMed: 25344836 MGI: J:218278
Perreault N; Sackett SD; Katz JP; Furth EE; Kaestner KH. 2005. Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon. Genes Dev 19(3):311-5. PubMed: 15650110 MGI: J:95893
Petrik MB; McEntee MF; Chiu CH; Whelan J. 2000. Antagonism of arachidonic acid is linked to the antitumorigenic effect of dietary eicosapentaenoic acid in Apc(Min/+) mice. J Nutr 130(5):1153-8. PubMed: 10801912 MGI: J:61833
Petrova TV; Nykanen A; Norrmen C; Ivanov KI; Andersson LC; Haglund C; Puolakkainen P; Wempe F; von Melchner H; Gradwohl G; Vanharanta S; Aaltonen LA; Saharinen J; Gentile M; Clarke A; Taipale J; Oliver G; Alitalo K. 2008. Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell 13(5):407-19. PubMed: 18455124 MGI: J:134772
Peuker K; Muff S; Wang J; Kunzel S; Bosse E; Zeissig Y; Luzzi G; Basic M; Strigli A; Ulbricht A; Kaser A; Arlt A; Chavakis T; van den Brink GR; Schafmayer C; Egberts JH; Becker T; Bianchi ME; Bleich A; Rocken C; Hampe J; Schreiber S; Baines JF; Blumberg RS; Zeissig S. 2016. Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Nat Med 22(5):506-15. PubMed: 27043494 MGI: J:234956
Philipp-Staheli J; Kim KH; Payne SR; Gurley KE; Liggitt D; Longton G; Kemp CJ. 2002. Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. Cancer Cell 1(4):355-68. PubMed: 12086850 MGI: J:77135
Pierre CC; Longo J; Mavor M; Milosavljevic SB; Chaudhary R; Gilbreath E; Yates C; Daniel JM. 2015. Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in Apc(Min/+) mice. Biochim Biophys Acta 1852(9):1846-55. PubMed: 26073433 MGI: J:233922
Pierre F; Perrin P; Bassonga E; Bornet F; Meflah K; Menanteau J. 1999. T cell status influences colon tumor occurrence in min mice fed short chain fructo-oligosaccharides as a diet supplement. Carcinogenesis 20(10):1953-6. PubMed: 10506110 MGI: J:58033
Pierre F; Perrin P; Champ M; Bornet F; Meflah K; Menanteau J. 1997. Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice. Cancer Res 57(2):225-8. PubMed: 9000559 MGI: J:38422
Pino MV; Kelley MF; Jayyosi Z. 2004. Promotion of Colon Tumors in C57BL/6J-APC(min)/+ Mice by Thiazolidinedione PPARgamma Agonists and a Structurally Unrelated PPARgamma Agonist. Toxicol Pathol 32(1):58-63. PubMed: 14713549 MGI: J:88111
Ploplis VA; Tipton H; Menchen H; Castellino FJ. 2007. A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice. J Pathol 213(3):266-74. PubMed: 17893885 MGI: J:126931
Pollard P; Deheragoda M; Segditsas S; Lewis A; Rowan A; Howarth K; Willis L; Nye E; McCart A; Mandir N; Silver A; Goodlad R; Stamp G; Cockman M; East P; Spencer-Dene B; Poulsom R; Wright N; Tomlinson I. 2009. The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. Gastroenterology 136(7):2204-2213.e1-13. PubMed: 19248780 MGI: J:180275
Poreba MA; Dong CX; Li SK; Stahl A; Miner JH; Brubaker PL. 2012. Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells. Am J Physiol Endocrinol Metab 303(7):E899-907. PubMed: 22871340 MGI: J:189655
Poulogiannis G; McIntyre RE; Dimitriadi M; Apps JR; Wilson CH; Ichimura K; Luo F; Cantley LC; Wyllie AH; Adams DJ; Arends MJ. 2010. PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. Proc Natl Acad Sci U S A 107(34):15145-50. PubMed: 20696900 MGI: J:221027
Poutahidis T; Cappelle K; Levkovich T; Lee CW; Doulberis M; Ge Z; Fox JG; Horwitz BH; Erdman SE. 2013. Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice. PLoS One 8(8):e73933. PubMed: 23991210 MGI: J:204916
Powell AE; Anderson EC; Davies PS; Silk AD; Pelz C; Impey S; Wong MH. 2011. Fusion between Intestinal Epithelial Cells and Macrophages in a Cancer Context Results in Nuclear Reprogramming. Cancer Res 71(4):1497-505. PubMed: 21303980 MGI: J:169371
Preston SL; Leedham SJ; Oukrif D; Deheregoda M; Goodlad RA; Poulsom R; Alison MR; Wright NA; Novelli M. 2008. The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse. J Pathol 214(3):294-301. PubMed: 18085615 MGI: J:130833
Pribluda A; Elyada E; Wiener Z; Hamza H; Goldstein RE; Biton M; Burstain I; Morgenstern Y; Brachya G; Billauer H; Biton S; Snir-Alkalay I; Vucic D; Schlereth K; Mernberger M; Stiewe T; Oren M; Alitalo K; Pikarsky E; Ben-Neriah Y. 2013. A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell 24(2):242-56. PubMed: 23890787 MGI: J:202528
Prokhortchouk A; Sansom O; Selfridge J; Caballero IM; Salozhin S; Aithozhina D; Cerchietti L; Meng FG; Augenlicht LH; Mariadason JM; Hendrich B; Melnick A; Prokhortchouk E; Clarke A; Bird A. 2006. Kaiso-deficient mice show resistance to intestinal cancer. Mol Cell Biol 26(1):199-208. PubMed: 16354691 MGI: J:104155
Putoczki TL; Thiem S; Loving A; Busuttil RA; Wilson NJ; Ziegler PK; Nguyen PM; Preaudet A; Farid R; Edwards KM; Boglev Y; Luwor RB; Jarnicki A; Horst D; Boussioutas A; Heath JK; Sieber OM; Pleines I; Kile BT; Nash A; Greten FR; McKenzie BS; Ernst M. 2013. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell 24(2):257-71. PubMed: 23948300 MGI: J:202609
Pysz MA; Leontieva OV; Bateman NW; Uronis JM; Curry KJ; Threadgill DW; Janssen KP; Robine S; Velcich A; Augenlicht LH; Black AR; Black JD. 2009. PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Exp Cell Res 315(8):1415-28. PubMed: 19232344 MGI: J:148198
Qian Y; Liu S; Guan Y; Pan H; Guan X; Qiu Z; Li L; Gao N; Zhao Y; Li X; Lu Y; Liu M; Li D. 2013. Lgr4-mediated Wnt/beta-catenin signaling in peritubular myoid cells is essential for spermatogenesis. Development 140(8):1751-61. PubMed: 23533175 MGI: J:195273
Qiu W; Carson-Walter EB; Kuan SF; Zhang L; Yu J. 2009. PUMA suppresses intestinal tumorigenesis in mice. Cancer Res 69(12):4999-5006. PubMed: 19491259 MGI: J:149660
Qiu W; Liu H; Sebastini A; Sun Q; Wang H; Zhang L; Yu J. 2013. An apoptosis-independent role of SMAC in tumor suppression. Oncogene 32(19):2380-9. PubMed: 22751125 MGI: J:198020
Qiu W; Wang X; Leibowitz B; Liu H; Barker N; Okada H; Oue N; Yasui W; Clevers H; Schoen RE; Yu J; Zhang L. 2010. Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proc Natl Acad Sci U S A 107(46):20027-32. PubMed: 21041628 MGI: J:166608
Qu Y; Gharbi N; Yuan X; Olsen JR; Blicher P; Dalhus B; Brokstad KA; Lin B; Oyan AM; Zhang W; Kalland KH; Ke X. 2016. Axitinib blocks Wnt/beta-catenin signaling and directs asymmetric cell division in cancer. Proc Natl Acad Sci U S A 113(33):9339-44. PubMed: 27482107 MGI: J:235620
Quyn AJ; Appleton PL; Carey FA; Steele RJ; Barker N; Clevers H; Ridgway RA; Sansom OJ; Nathke IS. 2010. Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell 6(2):175-81. PubMed: 20144789 MGI: J:157067
Radulescu S; Brookes MJ; Salgueiro P; Ridgway RA; McGhee E; Anderson K; Ford SJ; Stones DH; Iqbal TH; Tselepis C; Sansom OJ. 2012. Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo. Cell Rep 2(2):270-82. PubMed: 22884366 MGI: J:196014
Radulescu S; Ridgway RA; Appleton P; Kroboth K; Patel S; Woodgett J; Taylor S; Nathke IS; Sansom OJ. 2010. Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol. Oncogene 29(49):6418-27. PubMed: 20729907 MGI: J:166564
Rajakangas J; Basu S; Salminen I; Mutanen M. 2003. Adenoma growth stimulation by the trans-10, cis-12 isomer of conjugated linoleic acid (CLA) is associated with changes in mucosal NF-kappaB and cyclin D1 protein levels in the Min mouse. J Nutr 133(6):1943-8. PubMed: 12771343 MGI: J:83718
Rajakangas J; Misikangas M; Paivarinta E; Mutanen M. 2008. Chemoprevention by white currant is mediated by the reduction of nuclear beta-catenin and NF-kappaB levels in Min mice adenomas. Eur J Nutr 47(3):115-22. PubMed: 18389329 MGI: J:147320
Rajakangas J; Pajari AM; Misikangas M; Mutanen M. 2006. Nuclear factor kappaB is downregulated and correlates with p53 in the Min mouse mucosa during an accelerated tumor growth. Int J Cancer 118(2):279-83. PubMed: 16049962 MGI: J:102785
Rajamanickam S; Velmurugan B; Kaur M; Singh RP; Agarwal R. 2010. Chemoprevention of Intestinal Tumorigenesis in APCmin/+ Mice by Silibinin. Cancer Res 70(6):2368-78. PubMed: 20215518 MGI: J:157975
Rakoff-Nahoum S; Medzhitov R. 2007. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317(5834):124-7. PubMed: 17615359 MGI: J:122812
Ramocki NM; Wilkins HR; Magness ST; Simmons JG; Scull BP; Lee GH; McNaughton KK; Lund PK. 2008. Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9. Endocrinology 149(1):261-7. PubMed: 17916629 MGI: J:131133
Rao CV; Swamy MV; Patlolla JM; Kopelovich L. 2008. Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ mice. Cancer Res 68(18):7670-5. PubMed: 18794156 MGI: J:140113
Rao CV; Yang YM; Swamy MV; Liu T; Fang Y; Mahmood R; Jhanwar-Uniyal M; Dai W. 2005. Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc Natl Acad Sci U S A 102(12):4365-70. PubMed: 15767571 MGI: J:97036
Rao VP; Poutahidis T; Ge Z; Nambiar PR; Boussahmain C; Wang YY; Horwitz BH; Fox JG; Erdman SE. 2006. Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Cancer Res 66(15):7395-400. PubMed: 16885333 MGI: J:112089
Rao VP; Poutahidis T; Ge Z; Nambiar PR; Horwitz BH; Fox JG; Erdman SE. 2006. Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice. Cancer Res 66(1):57-61. PubMed: 16397216 MGI: J:105039
Raufman JP; Shant J; Xie G; Cheng K; Gao XM; Shiu B; Shah N; Drachenberg CB; Heath J; Wess J; Khurana S. 2011. Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice. Carcinogenesis 32(9):1396-402. PubMed: 21705482 MGI: J:175453
Reed KR; Sansom OJ; Hayes AJ; Gescher AJ; Winton DJ; Peters JM; Clarke AR. 2004. PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene 23(55):8992-6. PubMed: 15480419 MGI: J:94711
Reilly PT; Teo WL; Low MJ; Amoyo-Brion AA; Dominguez-Brauer C; Elia AJ; Berger T; Greicius G; Pettersson S; Mak TW. 2013. Lipocalin 2 performs contrasting, location-dependent roles in APCmin tumor initiation and progression. Oncogene 32(10):1233-9. PubMed: 22614012 MGI: J:193360
Reitmair AH; Cai JC; Bjerknes M; Redston M; Cheng H; Pind MT; Hay K; Mitri A; Bapat BV; Mak TW; Gallinger S. 1996. MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis. Cancer Res 56(13):2922-6. PubMed: 8674041 MGI: J:75393
Ridnour LA; Dhanapal S; Hoos M; Wilson J; Lee J; Cheng RY; Brueggemann EE; Hines HB; Wilcock DM; Vitek MP; Wink DA; Colton CA. 2012. Nitric oxide-mediated regulation of beta-amyloid clearance via alterations of MMP-9/TIMP-1. J Neurochem 123(5):736-49. PubMed: 23016931 MGI: J:190735
Rinella ES; Threadgill DW. 2012. Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials. PLoS One 7(6):e39552. PubMed: 22761823 MGI: J:187920
Ritchie KJ; Walsh S; Sansom OJ; Henderson CJ; Wolf CR. 2009. Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi. Proc Natl Acad Sci U S A :. PubMed: 19915149 MGI: J:155584
Ritland SR; Gendler SJ. 1999. Chemoprevention of intestinal adenomas in the ApcMin mouse by piroxicam: kinetics, strain effects and resistance to chemosuppression. Carcinogenesis 20(1):51-8. PubMed: 9934849 MGI: J:52249
Ritland SR; Gendler SJ; Burgart LJ; Fry DW; Nelson JM; Bridges AJ; Andress L; Karnes WE Jr. 2000. Inhibition of epidermal growth factor receptor tyrosine kinase fails to suppress adenoma formation in ApcMin mice but induces duodenal injury. Cancer Res 60(17):4678-81. PubMed: 10987266 MGI: J:64399
Ritland SR; Leighton JA; Hirsch RE; Morrow JD; Weaver AL; Gendler SJ. 1999. Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse. Clin Cancer Res 5(4):855-63. PubMed: 10213222 MGI: J:54378
Robanus-Maandag EC; Koelink PJ; Breukel C; Salvatori DC; Jagmohan-Changur SC; Bosch CA; Verspaget HW; Devilee P; Fodde R; Smits R. 2010. A new conditional Apc-mutant mouse model for colorectal cancer. Carcinogenesis 31(5):946-52. PubMed: 20176656 MGI: J:159883
Roberts RB; Min L; Washington MK; Olsen SJ; Settle SH; Coffey RJ; Threadgill DW. 2002. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A 99(3):1521-6. PubMed: 11818567 MGI: J:74510
Rodilla V; Villanueva A; Obrador-Hevia A; Robert-Moreno A; Fernandez-Majada V; Grilli A; Lopez-Bigas N; Bellora N; Alba MM; Torres F; Dunach M; Sanjuan X; Gonzalez S; Gridley T; Capella G; Bigas A; Espinosa L. 2009. Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A 106(15):6315-20. PubMed: 19325125 MGI: J:147760
Rodrigues P; Macaya I; Bazzocco S; Mazzolini R; Andretta E; Dopeso H; Mateo-Lozano S; Bilic J; Carton-Garcia F; Nieto R; Suarez-Lopez L; Afonso E; Landolfi S; Hernandez-Losa J; Kobayashi K; Ramon y Cajal S; Tabernero J; Tebbutt NC; Mariadason JM; Schwartz S Jr; Arango D. 2014. RHOA inactivation enhances Wnt signalling and promotes colorectal cancer. Nat Commun 5:5458. PubMed: 25413277 MGI: J:225289
Rogers AB; Fox JG. 2004. Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer. Am J Physiol Gastrointest Liver Physiol 286(3):G361-6. PubMed: 14766534 MGI: J:88079
Roose J; Huls G; van Beest M; Moerer P; van der Horn K; Goldschmeding R; Logtenberg T; Clevers H. 1999. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science 285(5435):1923-6. PubMed: 10489374 MGI: J:57721
Rossi C; Di Lena A; La Sorda R; Lattanzio R; Antolini L; Patassini C; Piantelli M; Alberti S. 2008. Intestinal tumour chemoprevention with the antioxidant lipoic acid stimulates the growth of breast cancer. Eur J Cancer 44(17):2696-704. PubMed: 18926695 MGI: J:143265
Roy BC; Subramaniam D; Ahmed I; Jala VR; Hester CM; Greiner KA; Haribabu B; Anant S; Umar S. 2015. Role of bacterial infection in the epigenetic regulation of Wnt antagonist WIF1 by PRC2 protein EZH2. Oncogene 34(34):4519-30. PubMed: 25486432 MGI: J:224250
Roy HK; Gulizia J; DiBaise JK; Karolski WJ; Ansari S; Madugula M; Hart J; Bissonnette M; Wali RK. 2004. Polyethylene glycol inhibits intestinal neoplasia and induces epithelial apoptosis in Apc(min) mice. Cancer Lett 215(1):35-42. PubMed: 15374630 MGI: J:93789
Roy HK; Iversen P; Hart J; Liu Y; Koetsier JL; Kim Y; Kunte DP; Madugula M; Backman V; Wali RK. 2004. Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension. Mol Cancer Ther 3(9):1159-65. PubMed: 15367710 MGI: J:93400
Roy HK; Karolski WJ; Wali RK; Ratashak A; Hart J; Smyrk TC. 2005. The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis. Cancer Lett 217(2):161-9. PubMed: 15617833 MGI: J:95217
Roy HK; Karoski WJ; Ratashak A; Smyrk TC. 2001. Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation. Br J Cancer 84(10):1412-6. PubMed: 11355956 MGI: J:69899
Roy HK; Kim YL; Wali RK; Liu Y; Koetsier J; Kunte DP; Goldberg MJ; Backman V. 2005. Spectral markers in preneoplastic intestinal mucosa: an accurate predictor of tumor risk in the MIN mouse. Cancer Epidemiol Biomarkers Prev 14(7):1639-45. PubMed: 16030095 MGI: J:103621
Rudolph KL; Millard M; Bosenberg MW; DePinho RA. 2001. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 28(2):155-9. PubMed: 11381263 MGI: J:69730
Saandi T; Baraille F; Derbal-Wolfrom L; Cattin AL; Benahmed F; Martin E; Cardot P; Duclos B; Ribeiro A; Freund JN; Duluc I. 2013. Regulation of the tumor suppressor homeogene Cdx2 by HNF4alpha in intestinal cancer. Oncogene 32(32):3782-8. PubMed: 22986531 MGI: J:199976
Sadakata H; Okazawa H; Sato T; Supriatna Y; Ohnishi H; Kusakari S; Murata Y; Ito T; Nishiyama U; Minegishi T; Harada A; Matozaki T. 2009. SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis. Genes Cells 14(3):295-308. PubMed: 19170756 MGI: J:146871
Saez E; Tontonoz P; Nelson MC; Alvarez JG; Ming UT; Baird SM; Thomazy VA; Evans RM. 1998. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nat Med 4(9):1058-61. PubMed: 9734400 MGI: J:49813
Sakamaki A; Katsuragi Y; Otsuka K; Tomita M; Obata M; Iwasaki T; Abe M; Sato T; Ochiai M; Sakuraba Y; Aoyagi Y; Gondo Y; Sakimura K; Nakagama H; Mishima Y; Kominami R. 2015. Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after gamma-irradiation through Wnt/beta-catenin pathway. Carcinogenesis 36(6):622-31. PubMed: 25827435 MGI: J:221957
Sakamori R; Yu S; Zhang X; Hoffman A; Sun J; Das S; Vedula P; Li G; Fu J; Walker F; Yang CS; Yi Z; Hsu W; Yu DH; Shen L; Rodriguez AJ; Taketo MM; Bonder EM; Verzi MP; Gao N. 2014. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res 74(19):5480-92. PubMed: 25113996 MGI: J:216187
Sakatani T; Kaneda A; Iacobuzio-Donahue CA; Carter MG; de Boom Witzel S; Okano H; Ko MS; Ohlsson R; Longo DL; Feinberg AP. 2005. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science 307(5717):1976-8. PubMed: 15731405 MGI: J:97083
Sale S; Tunstall RG; Ruparelia KC; Potter GA; Steward WP; Gescher AJ. 2005. Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells. Int J Cancer 115(2):194-201. PubMed: 15688382 MGI: J:96796
Sanchez-Tena S; Lizarraga D; Miranda A; Vinardell MP; Garcia-Garcia F; Dopazo J; Torres JL; Saura-Calixto F; Capella G; Cascante M. 2013. Grape antioxidant dietary fiber inhibits intestinal polyposis in ApcMin/+ mice: relation to cell cycle and immune response. Carcinogenesis 34(8):1881-8. PubMed: 23615403 MGI: J:199484
Sanchez-Tena S; Reyes-Zurita FJ; Diaz-Moralli S; Vinardell MP; Reed M; Garcia-Garcia F; Dopazo J; Lupianez JA; Gunther U; Cascante M. 2013. Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming. PLoS One 8(3):e59392. PubMed: 23527181 MGI: J:199536
Sanchez-Tillo E; de Barrios O; Siles L; Cuatrecasas M; Castells A; Postigo A. 2011. beta-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness. Proc Natl Acad Sci U S A 108(48):19204-9. PubMed: 22080605 MGI: J:180210
Sancho R; Blake SM; Tendeng C; Clurman BE; Lewis J; Behrens A. 2013. Fbw7 repression by hes5 creates a feedback loop that modulates notch-mediated intestinal and neural stem cell fate decisions. PLoS Biol 11(6):e1001586. PubMed: 23776410 MGI: J:201426
Sancho R; Jandke A; Davis H; Diefenbacher ME; Tomlinson I; Behrens A. 2010. F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology 139(3):929-41. PubMed: 20638938 MGI: J:172416
Sansom OJ; Berger J; Bishop SM; Hendrich B; Bird A; Clarke AR. 2003. Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet 34(2):145-7. PubMed: 12730693 MGI: J:83087
Sansom OJ; Mansergh FC; Evans MJ; Wilkins JA; Clarke AR. 2007. Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice. Gut 56(10):1410-4. PubMed: 17299058 MGI: J:139856
Sansom OJ; Stark LA; Dunlop MG; Clarke AR. 2001. Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice. Cancer Res 61(19):7060-4. PubMed: 11585736 MGI: J:72233
Sato T; van Es JH; Snippert HJ; Stange DE; Vries RG; van den Born M; Barker N; Shroyer NF; van de Wetering M; Clevers H. 2011. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469(7330):415-8. PubMed: 21113151 MGI: J:168728
Sattar A; Hewer A; Phillips DH; Campbell FC. 1999. Metabolic proficiency and benzo[a]pyrene DNA adduct formation in APCMin mouse adenomas and uninvolved mucosa. Carcinogenesis 20(6):1097-101. PubMed: 10357794 MGI: J:55569
Savari S; Chandrashekar NK; Osman J; Douglas D; Bellamkonda K; Jonsson G; Juhas M; Greicius G; Pettersson S; Sjolander A. 2016. Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model. Carcinogenesis 37(5):491-9. PubMed: 26979937 MGI: J:231762
Scheeren FA; Kuo AH; van Weele LJ; Cai S; Glykofridis I; Sikandar SS; Zabala M; Qian D; Lam JS; Johnston D; Volkmer JP; Sahoo D; van de Rijn M; Dirbas FM; Somlo G; Kalisky T; Rothenberg ME; Quake SR; Clarke MF. 2014. A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Nat Cell Biol 16(12):1238-48. PubMed: 25362351 MGI: J:217693
Schmelz EM; Roberts PC; Kustin EM; Lemonnier LA; Sullards MC; Dillehay DL; Merrill AH Jr. 2001. Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. Cancer Res 61(18):6723-9. PubMed: 11559543 MGI: J:71590
Schneider FT; Schanzer A; Czupalla CJ; Thom S; Engels K; Schmidt MH; Plate KH; Liebner S. 2010. Sonic hedgehog acts as a negative regulator of {beta}-catenin signaling in the adult tongue epithelium. Am J Pathol 177(1):404-14. PubMed: 20508033 MGI: J:162106
Schoonjans K; Dubuquoy L; Mebis J; Fayard E; Wendling O; Haby C; Geboes K; Auwerx J. 2005. Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Proc Natl Acad Sci U S A 102(6):2058-62. PubMed: 15684064 MGI: J:96476
Scott DJ; Hull MA; Cartwright EJ; Lam WK; Tisbury A; Poulsom R; Markham AF; Bonifer C; Coletta PL. 2001. Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the apc(min/+) mouse. Gastroenterology 121(4):889-99. PubMed: 11606502 MGI: J:72030
Segditsas S; Sieber O; Deheragoda M; East P; Rowan A; Jeffery R; Nye E; Clark S; Spencer-Dene B; Stamp G; Poulsom R; Suraweera N; Silver A; Ilyas M; Tomlinson I. 2008. Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. Hum Mol Genet 17(24):3864-75. PubMed: 18782851 MGI: J:143119
Sehayek E; Ono JG; Duncan EM; Batta AK; Salen G; Shefer S; Neguyen LB; Yang K; Lipkin M; Breslow JL. 2001. Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice. J Lipid Res 42(8):1250-6. PubMed: 11483626 MGI: J:70721
Serebrennikova OB; Tsatsanis C; Mao C; Gounaris E; Ren W; Siracusa LD; Eliopoulos AG; Khazaie K; Tsichlis PN. 2012. Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation. Proc Natl Acad Sci U S A 109(18):E1082-91. PubMed: 22451924 MGI: J:183540
Shailubhai K; Yu HH; Karunanandaa K; Wang JY; Eber SL; Wang Y; Joo NS; Kim HD; Miedema BW; Abbas SZ; Boddupalli SS; Currie MG; Forte LR. 2000. Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. Cancer Res 60(18):5151-7. PubMed: 11016642 MGI: J:64784
Shao J; Washington MK; Saxena R; Sheng H. 2007. Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin. Carcinogenesis 28(12):2476-83. PubMed: 17693663 MGI: J:127726
Shao L; Oshima S; Duong B; Advincula R; Barrera J; Malynn BA; Ma A. 2013. A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis. PLoS One 8(5):e62223. PubMed: 23671587 MGI: J:200528
Sharma A; Sen JM. 2013. Molecular basis for the tissue specificity of beta-catenin oncogenesis. Oncogene 32(15):1901-9. PubMed: 22689057 MGI: J:197228
Shattuck-Brandt RL; Lamps LW; Heppner Goss KJ; DuBois RN; Matrisian LM. 1999. Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. Mol Carcinog 24(3):177-87. PubMed: 10204802 MGI: J:56012
Shattuck-Brandt RL; Varilek GW; Radhika A; Yang F; Washington MK; DuBois RN. 2000. Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice Gastroenterology 118(2):337-45. PubMed: 10648462 MGI: J:60015
Shelton DN; Sandoval IT; Eisinger A; Chidester S; Ratnayake A; Ireland CM; Jones DA. 2006. Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. Cancer Res 66(15):7571-7. PubMed: 16885356 MGI: J:112096
Shen G; Khor TO; Hu R; Yu S; Nair S; Ho CT; Reddy BS; Huang MT; Newmark HL; Kong AN. 2007. Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Res 67(20):9937-44. PubMed: 17942926 MGI: J:126014
Shi L; Itoh F; Itoh S; Takahashi S; Yamamoto M; Kato M. 2008. Ephrin-A1 promotes the malignant progression of intestinal tumors in Apc(min/+) mice. Oncogene 27(23):3265-73. PubMed: 18246128 MGI: J:135593
Shi Z; Chiang CI; Mistretta TA; Major A; Mori-Akiyama Y. 2013. SOX9 directly regulates IGFBP-4 in the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol 305(1):G74-83. PubMed: 23660500 MGI: J:202780
Shoemaker AR; Haigis KM; Baker SM; Dudley S; Liskay RM; Dove WF. 2000. Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice. Oncogene 19(23):2774-9. PubMed: 10851078 MGI: J:62824
Shoemaker AR; Luongo C; Moser AR; Marton LJ; Dove WF. 1997. Somatic mutational mechanisms involved in intestinal tumor formation in Min mice. Cancer Res 57(10):1999-2006. PubMed: 9157997 MGI: J:40435
Shoemaker AR; Moser AR; Dove WF. 1995. N-ethyl-N-nitrosourea treatment of multiple intestinal neoplasia (Min) mice: age-related effects on the formation of intestinal adenomas, cystic crypts, and epidermoid cysts. Cancer Res 55(19):4479-85. PubMed: 7671263 MGI: J:29099
Shoemaker AR; Moser AR; Midgley CA; Clipson L; Newton MA; Dove WF. 1998. A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice. Proc Natl Acad Sci U S A 95(18):10826-31. PubMed: 9724789 MGI: J:49809
Sibani S; Melnyk S; Pogribny IP; Wang W; Hiou-Tim F; Deng L; Trasler J; James SJ; Rozen R. 2002. Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice. Carcinogenesis 23(1):61-5. PubMed: 11756224 MGI: J:73559
Sieber OM; Howarth KM; Thirlwell C; Rowan A; Mandir N; Goodlad RA; Gilkar A; Spencer-Dene B; Stamp G; Johnson V; Silver A; Yang H; Miller JH; Ilyas M; Tomlinson IP. 2004. Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice. Cancer Res 64(24):8876-81. PubMed: 15604247 MGI: J:94956
Silverman KA; Koratkar R; Siracusa LD; Buchberg AM. 2002. Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia. Genome Res 12(1):88-97. PubMed: 11779834 MGI: J:73854
Singh N; Gurav A; Sivaprakasam S; Brady E; Padia R; Shi H; Thangaraju M; Prasad PD; Manicassamy S; Munn DH; Lee JR; Offermanns S; Ganapathy V. 2014. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 40(1):128-39. PubMed: 24412617 MGI: J:209390
Sinnamon MJ; Carter KJ; Sims LP; Lafleur B; Fingleton B; Matrisian LM. 2008. A protective role of mast cells in intestinal tumorigenesis. Carcinogenesis 29(4):880-6. PubMed: 18258601 MGI: J:133499
Smits R; Hofland N; Edelmann W; Geugien M; Jagmohan-Changur S; Albuquerque C; Breukel C; Kucherlapati R; Kielman MF; Fodde R. 2000. Somatic apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity Genes Chromosomes Cancer 29(3):229-39. PubMed: 10992298 MGI: J:64667
Smits R; van der Houven van Oordt W; Luz A; Zurcher C; Jagmohan-Changur S ; Breukel C ; Khan PM ; Fodde R. 1998. Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. Gastroenterology 114(2):275-83. PubMed: 9453487 MGI: J:46025
Snook AE; Li P; Stafford BJ; Faul EJ; Huang L; Birbe RC; Bombonati A; Schulz S; Schnell MJ; Eisenlohr LC; Waldman SA. 2009. Lineage-specific T-cell responses to cancer mucosa antigen oppose systemic metastases without mucosal inflammatory disease. Cancer Res 69(8):3537-44. PubMed: 19351847 MGI: J:147725
Sodir NM; Chen X; Park R; Nickel AE; Conti PS; Moats R; Bading JR; Shibata D; Laird PW. 2006. Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of ApcMin/+ Mice. Cancer Res 66(17):8430-8. PubMed: 16951153 MGI: J:112366
Sodring M; Gunnes G; Paulsen JE. 2016. Spontaneous initiation, promotion and progression of colorectal cancer in the novel A/J Min/+ mouse. Int J Cancer 138(8):1936-46. PubMed: 26566853 MGI: J:230063
Sodring M; Oostindjer M; Egelandsdal B; Paulsen JE. 2015. Effects of hemin and nitrite on intestinal tumorigenesis in the A/J Min/+ mouse model. PLoS One 10(4):e0122880. PubMed: 25836260 MGI: J:233419
Sohn KJ; Choi M; Song J; Chan S; Medline A; Gallinger S; Kim YI. 2003. Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice. Carcinogenesis 24(2):217-24. PubMed: 12584170 MGI: J:79407
Son JS; Khair S; Pettet DW 3rd; Ouyang N; Tian X; Zhang Y; Zhu W; Mackenzie GG; Robertson CE; Ir D; Frank DN; Rigas B; Li E. 2015. Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice. PLoS One 10(6):e0127985. PubMed: 26121046 MGI: J:233885
Song J; Medline A; Mason JB; Gallinger S; Kim YI. 2000. Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse Cancer Res 60(19):5434-40. PubMed: 11034085 MGI: J:65027
Song J; Sohn KJ; Medline A; Ash C; Gallinger S; Kim YI. 2000. Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice. Cancer Res 60(12):3191-9. PubMed: 10866310 MGI: J:62926
Song X; Gao H; Lin Y; Yao Y; Zhu S; Wang J; Liu Y; Yao X; Meng G; Shen N; Shi Y; Iwakura Y; Qian Y. 2014. Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity 40(1):140-52. PubMed: 24412611 MGI: J:209396
Sorensen IK; Kristiansen E; Mortensen A; Nicolaisen GM; Wijnands JA; van Kranen HJ; van Kreijl CF. 1998. The effect of soy isoflavones on the development of intestinal neoplasia in ApcMin mouse. Cancer Lett 130(1-2):217-25. PubMed: 9751277 MGI: J:49938
Stadthagen G; Tehler D; Hoyland-Kroghsbo NM; Wen J; Krogh A; Jensen KT; Santoni-Rugiu E; Engelholm LH; Lund AH. 2013. Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice. PLoS Genet 9(10):e1003913. PubMed: 24204315 MGI: J:205135
Stark LA; Reid K; Sansom OJ; Din FV; Guichard S; Mayer I; Jodrell DI; Clarke AR; Dunlop MG. 2007. Aspirin activates the NF-{kappa}B signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis 28(5):968-76. PubMed: 17132819 MGI: J:121064
Starr TK; Scott PM; Marsh BM; Zhao L; Than BL; O'Sullivan MG; Sarver AL; Dupuy AJ; Largaespada DA; Cormier RT. 2011. A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci U S A 108(14):5765-70. PubMed: 21436051 MGI: J:171211
Steffensen IL; Alexander J. 2006. Impact of genetic background on spontaneous or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumorigenesis in Min/+ mice. Cancer Lett 240(2):289-96. PubMed: 16343741 MGI: J:114594
Steffensen IL; Janak K; Hegstad S; Andreassen A; Paulsen JE; Reistad R; Alexander J. 2003. Incorporation of the Food Mutagen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP) into Fur and Correlation with Intestinal Tumourigenesis in Min/+ Mice. Pharmacol Toxicol 92(3):131-6. PubMed: 12753428 MGI: J:84213
Steffensen IL; Paulsen JE; Alexander J. 2002. The food mutagen 2-amino-9H-pyrido[2,3-b]indole (AalphaC) but not its methylated form (MeAalphaC) increases intestinal tumorigenesis in neonatally exposed multiple intestinal neoplasia mice. Carcinogenesis 23(8):1373-8. PubMed: 12151357 MGI: J:78063
Steffensen IL; Paulsen JE; Eide TJ; Alexander J. 1997. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine increases the numbers of tumors, cystic crypts and aberrant crypt foci in multiple intestinal neoplasia mice. Carcinogenesis 18(5):1049-54. PubMed: 9163695 MGI: J:40366
Steffensen IL; Schut HA; Nesland JM; Tanaka K; Alexander J. 2006. Role of nucleotide excision repair deficiency in intestinal tumorigenesis in multiple intestinal neoplasia (Min) mice. Mutat Res 611(1-2):71-82. PubMed: 16962818 MGI: J:118104
Steffensen IL; Schut HA; Paulsen JE; Andreassen A; Alexander J. 2001. Intestinal tumorigenesis in multiple intestinal neoplasia mice induced by the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: perinatal susceptibility, regional variation, and correlation with DNA adducts. Cancer Res 61(24):8689-96. PubMed: 11751386 MGI: J:73361
Steinbrecher KA; Tuohy TM; Heppner Goss K; Scott MC; Witte DP; Groden J; Cohen MB. 2000. Expression of guanylin is downregulated in mouse and human intestinal adenomas. Biochem Biophys Res Commun 273(1):225-30. PubMed: 10873591 MGI: J:62891
Suganuma M; Ohkura Y; Okabe S; Fujiki H. 2001. Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice. J Cancer Res Clin Oncol 127(1):69-72. PubMed: 11206275 MGI: J:67939
Sun X; Essalmani R; Seidah NG; Prat A. 2009. The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model. Mol Cancer 8:73. PubMed: 19737405 MGI: J:220950
Sung HJ; Ma W; Starost MF; Lago CU; Lim PK; Sack MN; Kang JG; Wang PY; Hwang PM. 2011. Ambient oxygen promotes tumorigenesis. PLoS One 6(5):e19785. PubMed: 21589870 MGI: J:172642
Sur IK; Hallikas O; Vaharautio A; Yan J; Turunen M; Enge M; Taipale M; Karhu A; Aaltonen LA; Taipale J. 2012. Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. Science 338(6112):1360-3. PubMed: 23118011 MGI: J:191217
Suraweera N; Haines J; McCart A; Rogers P; Latchford A; Coster M; Polanco-Echeverry G; Guenther T; Wang J; Sieber O; Tomlinson I; Silver A. 2006. Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice. Hum Mol Genet 15(23):3429-35. PubMed: 17062636 MGI: J:117129
Sussan TE; Yang A; Li F; Ostrowski MC; Reeves RH. 2008. Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature 451(7174):73-5. PubMed: 18172498 MGI: J:131046
Suzui M; Okuno M; Tanaka T; Nakagama H; Moriwaki H. 2002. Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation. Cancer Lett 183(1):31-41. PubMed: 12049812 MGI: J:77169
Swallow CJ; Partridge EA; Macmillan JC; Tajirian T; DiGuglielmo GM; Hay K; Szweras M; Jahnen-Dechent W; Wrana JL; Redston M; Gallinger S; Dennis JW. 2004. alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression. Cancer Res 64(18):6402-9. PubMed: 15374947 MGI: J:93668
Swamy MV; Patlolla JM; Steele VE; Kopelovich L; Reddy BS; Rao CV. 2006. Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice. Cancer Res 66(14):7370-7. PubMed: 16849589 MGI: J:112125
Swietlicki EA; Bala S; Lu J; Shaker A; Kularatna G; Levin MS; Rubin DC. 2013. Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion. Am J Physiol Gastrointest Liver Physiol 305(8):G564-72. PubMed: 23886856 MGI: J:210570
Symolon H; Schmelz EM; Dillehay DL; Merrill AH Jr. 2004. Dietary Soy Sphingolipids Suppress Tumorigenesis and Gene Expression in 1,2-Dimethylhydrazine-Treated CF1 Mice and Apc(Min/+) Mice. J Nutr 134(5):1157-1161. PubMed: 15113963 MGI: J:90172
Takeda H; Sonoshita M; Oshima H; Sugihara K; Chulada PC; Langenbach R; Oshima M; Taketo MM. 2003. Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis. Cancer Res 63(16):4872-7. PubMed: 12941808 MGI: J:85136
Takeda H; Wei Z; Koso H; Rust AG; Yew CC; Mann MB; Ward JM; Adams DJ; Copeland NG; Jenkins NA. 2015. Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression. Nat Genet 47(2):142-50. PubMed: 25559195 MGI: J:220352
Taketo MM. 2006. Mouse models of gastrointestinal tumors. Cancer Sci 97(5):355-61. PubMed: 16630131 MGI: J:116407
Tanaka T; Kohno H; Suzuki R; Hata K; Sugie S; Niho N; Sakano K; Takahashi M; Wakabayashi K. 2006. Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: Inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms. Int J Cancer 118(1):25-34. PubMed: 16049979 MGI: J:101781
Tao S; Tang D; Morita Y; Sperka T; Omrani O; Lechel A; Sakk V; Kraus J; Kestler HA; Kuhl M; Rudolph KL. 2015. Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage. EMBO J 34(5):624-40. PubMed: 25609789 MGI: J:219566
Tao Y; Messer JS; Goss KH; Hart J; Bissonnette M; Chang EB. 2016. Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model. Carcinogenesis 37(7):731-9. PubMed: 27207671 MGI: J:232780
Than BL; Goos JA; Sarver AL; O'Sullivan MG; Rod A; Starr TK; Fijneman RJ; Meijer GA; Zhao L; Zhang Y; Largaespada DA; Scott PM; Cormier RT. 2014. The role of KCNQ1 in mouse and human gastrointestinal cancers. Oncogene 33(29):3861-8. PubMed: 23975432 MGI: J:212747
Than BL; Linnekamp JF; Starr TK; Largaespada DA; Rod A; Zhang Y; Bruner V; Abrahante J; Schumann A; Luczak T; Niemczyk A; O'Sullivan MG; Medema JP; Fijneman RJ; Meijer GA; Van den Broek E; Hodges CA; Scott PM; Vermeulen L; Cormier RT. 2016. CFTR is a tumor suppressor gene in murine and human intestinal cancer. Oncogene :. PubMed: 26751771 MGI: J:227977
Thangaraju M; Cresci GA; Liu K; Ananth S; Gnanaprakasam JP; Browning DD; Mellinger JD; Smith SB; Digby GJ; Lambert NA; Prasad PD; Ganapathy V. 2009. GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. Cancer Res 69(7):2826-32. PubMed: 19276343 MGI: J:147284
Thliveris AT; Clipson L; Sommer LL; Schoenike BA; Hasenstein JR; Schlamp CL; Alexander CM; Newton MA; Dove WF; Amos-Landgraf JM. 2012. Regulated Expression of Chromobox Homolog 5 Revealed in Tumors of Apc(Min) (/+) ROSA11 Gene Trap Mice. G3 (Bethesda) 2(5):569-78. PubMed: 22670227 MGI: J:185981
Thliveris AT; Halberg RB; Clipson L; Dove WF; Sullivan R; Washington MK; Stanhope S; Newton MA. 2005. Polyclonality of familial murine adenomas: analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions. Proc Natl Acad Sci U S A 102(19):6960-5. PubMed: 15870186 MGI: J:99067
Thliveris AT; Schwefel B; Clipson L; Plesh L; Zahm CD; Leystra AA; Washington MK; Sullivan R; Deming DA; Newton MA; Halberg RB. 2013. Transformation of epithelial cells through recruitment leads to polyclonal intestinal tumors. Proc Natl Acad Sci U S A 110(28):11523-8. PubMed: 23798428 MGI: J:198817
Thompson JA; Eades-Perner AM; Ditter M; Muller WJ; Zimmermann W. 1997. Expression of transgenic carcinoembryonic antigen (CEA) in tumor-prone mice: an animal model for CEA-directed tumor immunotherapy. Int J Cancer 72(1):197-202. PubMed: 9212243 MGI: J:41380
Tokairin Y; Kakinuma S; Arai M; Nishimura M; Okamoto M; Ito E; Akashi M; Miki Y; Kawano T; Iwai T; Shimada Y. 2006. Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCC. Int J Exp Pathol 87(2):89-99. PubMed: 16623753 MGI: J:121492
Tomimoto A; Endo H; Sugiyama M; Fujisawa T; Hosono K; Takahashi H; Nakajima N; Nagashima Y; Wada K; Nakagama H; Nakajima A. 2008. Metformin suppresses intestinal polyp growth in ApcMin/+ mice. Cancer Sci 99(11):2136-41. PubMed: 18803638 MGI: J:142720
Tomita H; Hirata A; Yamada Y; Hata K; Oyama T; Mori H; Yamashita S; Ushijima T; Hara A. 2010. Suppressive effect of global DNA hypomethylation on gastric carcinogenesis. Carcinogenesis 31(9):1627-33. PubMed: 20622006 MGI: J:163640
Ton-That H; Kaestner KH; Shields JM; Mahatanankoon CS; Yang VW. 1997. Expression of the gut-enriched Kruppel-like factor gene during development and intestinal tumorigenesis. FEBS Lett 419(2-3):239-43. PubMed: 9428642 MGI: J:45361
Trasler J; Deng L; Melnyk S; Pogribny I; Hiou-Tim F; Sibani S; Oakes C; Li E; James SJ; Rozen R. 2003. Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice. Carcinogenesis 24(1):39-45. PubMed: 12538347 MGI: J:81577
Tripodo C; Sangaletti S; Guarnotta C; Piccaluga PP; Cacciatore M; Giuliano M; Franco G; Chiodoni C; Sciandra M; Miotti S; Calvaruso G; Care A; Florena AM; Scotlandi K; Orazi A; Pileri SA; Colombo MP. 2012. Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion. Blood 120(17):3541-54. PubMed: 22955913 MGI: J:193220
Tu HC; Schwitalla S; Qian Z; LaPier GS; Yermalovich A; Ku YC; Chen SC; Viswanathan SR; Zhu H; Nishihara R; Inamura K; Kim SA; Morikawa T; Mima K; Sukawa Y; Yang J; Meredith G; Fuchs CS; Ogino S; Daley GQ. 2015. LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev 29(10):1074-86. PubMed: 25956904 MGI: J:222249
Tucker JM; Murphy JT; Kisiel N; Diegelman P; Barbour KW; Davis C; Medda M; Alhonen L; Janne J; Kramer DL; Porter CW; Berger FG. 2005. Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase. Cancer Res 65(12):5390-8. PubMed: 15958588 MGI: J:99381
Uddin MJ; Crews BC; Blobaum AL; Kingsley PJ; Gorden DL; McIntyre JO; Matrisian LM; Subbaramaiah K; Dannenberg AJ; Piston DW; Marnett LJ. 2010. Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents. Cancer Res 70(9):3618-27. PubMed: 20430759 MGI: J:159452
Ueo T; Imayoshi I; Kobayashi T; Ohtsuka T; Seno H; Nakase H; Chiba T; Kageyama R. 2012. The role of Hes genes in intestinal development, homeostasis and tumor formation. Development 139(6):1071-82. PubMed: 22318232 MGI: J:182751
Ushida Y; Sekine K; Kuhara T; Takasuka N; Iigo M; Tsuda H. 1998. Inhibitory effects of bovine lactoferrin on intestinal polyposis in the Apc(Min) mouse. Cancer Lett 134(2):141-5. PubMed: 10025873 MGI: J:88991
Valvezan AJ; Huang J; Lengner CJ; Pack M; Klein PS. 2014. Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech 7(1):63-71. PubMed: 24092877 MGI: J:208734
Vermeulen L; Morrissey E; van der Heijden M; Nicholson AM; Sottoriva A; Buczacki S; Kemp R; Tavare S; Winton DJ. 2013. Defining stem cell dynamics in models of intestinal tumor initiation. Science 342(6161):995-8. PubMed: 24264992 MGI: J:205193
Vinuesa AG; Sancho R; Garcia-Limones C; Behrens A; ten Dijke P; Calzado MA; Munoz E. 2012. Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer. Cancer Res 72(7):1705-16. PubMed: 22396497 MGI: J:184884
Vooijs M; Ong CT; Hadland B; Huppert S; Liu Z; Korving J; van den Born M; Stappenbeck T; Wu Y; Clevers H; Kopan R. 2007. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development 134(3):535-44. PubMed: 17215306 MGI: J:119910
Waaler J; Machon O; von Kries JP; Wilson SR; Lundenes E; Wedlich D; Gradl D; Paulsen JE; Machonova O; Dembinski JL; Dinh H; Krauss S. 2011. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res 71(1):197-205. PubMed: 21199802 MGI: J:167771
Wagenaar-Miller RA; Hanley G; Shattuck-Brandt R; DuBois RN; Bell RL; Matrisian LM; Morgan DW. 2003. Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. Br J Cancer 88(9):1445-52. PubMed: 12778076 MGI: J:83488
Wali RK; Roy HK; Kim YL; Liu Y; Koetsier JL; Kunte DP; Goldberg MJ; Turzhitsky V; Backman V. 2005. Increased microvascular blood content is an early event in colon carcinogenesis. Gut 54(5):654-60. PubMed: 15831911 MGI: J:98653
Wang AS; Kozlov SV; Stewart CL; Horn HF. 2015. Tissue specific loss of A-type lamins in the gastrointestinal epithelium can enhance polyp size. Differentiation 89(1-2):11-21. PubMed: 25578479 MGI: J:220874
Wang D; Buchanan FG; Wang H; Dey SK; DuBois RN. 2005. Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. Cancer Res 65(5):1822-9. PubMed: 15753380 MGI: J:96998
Wang D; Fu L; Ning W; Guo L; Sun X; Dey SK; Chaturvedi R; Wilson KT; DuBois RN. 2014. Peroxisome proliferator-activated receptor delta promotes colonic inflammation and tumor growth. Proc Natl Acad Sci U S A 111(19):7084-9. PubMed: 24763687 MGI: J:211077
Wang D; Wang H; Brown J; Daikoku T; Ning W; Shi Q; Richmond A; Strieter R; Dey SK; DuBois RN. 2006. CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med 203(4):941-51. PubMed: 16567391 MGI: J:123749
Wang D; Wang H; Guo Y; Ning W; Katkuri S; Wahli W; Desvergne B; Dey SK; DuBois RN. 2006. Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proc Natl Acad Sci U S A 103(50):19069-74. PubMed: 17148604 MGI: J:118285
Wang D; Wang H; Ning W; Backlund MG; Dey SK; DuBois RN. 2008. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res 68(15):6468-76. PubMed: 18676872 MGI: J:140031
Wang D; Wang H; Shi Q; Katkuri S; Walhi W; Desvergne B; Das SK; Dey SK; DuBois RN. 2004. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 6(3):285-95. PubMed: 15380519 MGI: J:93551
Wang H; Teske D; Tess A; Kohlhepp R; Choi Y; Kendziorski C; Moser AR. 2007. Identification of novel modifier loci of Apc Min affecting mammary tumor development. Cancer Res 67(23):11226-33. PubMed: 18056448 MGI: J:128481
Wang L; Cao H; Lu N; Liu L; Wang B; Hu T; Israel DA; Peek RM Jr; Polk DB; Yan F. 2013. Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells. PLoS One 8(2):e56666. PubMed: 23457600 MGI: J:199397
Wang X; Li X; Fan F; Jiao S; Wang L; Zhu L; Pan Y; Wu G; Ling ZQ; Fang J; Chen Y. 2012. PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers. Carcinogenesis 33(11):2228-35. PubMed: 22828136 MGI: J:193153
Wasan HS; Novelli M; Bee J; Bodmer WF. 1997. Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proc Natl Acad Sci U S A 94(7):3308-13. PubMed: 9096389 MGI: J:39278
Wasan HS; Park HS; Liu KC; Mandir NK; Winnett A; Sasieni P; Bodmer WF; Goodlad RA; Wright NA. 1998. APC in the regulation of intestinal crypt fission. J Pathol 185(3):246-55. PubMed: 9771477 MGI: J:110641
Watanabe K; Kawamori T; Nakatsugi S; Ohta T; Ohuchida S; Yamamoto H; Maruyama T; Kondo K; Ushikubi F; Narumiya S; Sugimura T; Wakabayashi K. 1999. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res 59(20):5093-6. PubMed: 10537280 MGI: J:59509
Watson SA; Smith AM. 2001. Hypergastrinemia promotes adenoma progression in the APC(Min-/+) mouse model of familial adenomatous polyposis. Cancer Res 61(2):625-31. PubMed: 11212260 MGI: J:67449
Weber GF; Bronson RT; Ilagan J; Cantor H; Schmits R; Mak TW. 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res 62(8):2281-6. PubMed: 11956084 MGI: J:76201
Wechter WJ; Kantoci D; Murray ED Jr; Quiggle DD; Leipold DD; Gibson KM ; McCracken JD. 1997. R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer. Cancer Res 57(19):4316-24. PubMed: 9331093 MGI: J:43175
Wechter WJ; Murray ED Jr; Kantoci D; Quiggle DD; Leipold DD; Gibson KM; McCracken JD. 2000. Treatment and survival study in the C57BL/6J-APC(Min)/+(Min) mouse with R-flurbiprofen. Life Sci 66(8):745-53. PubMed: 10680582 MGI: J:60796
Weis B; Schmidt J; Maamar H; Raj A; Lin H; Toth C; Riedmann K; Raddatz G; Seitz HK; Ho AD; Lyko F; Linhart HG. 2015. Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a. Oncogene 34(14):1822-30. PubMed: 24837369 MGI: J:221277
Wetmore C; Eberhart DE; Curran T. 2001. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61(2):513-6. PubMed: 11212243 MGI: J:67452
Weyant MJ; Carothers AM; Dannenberg AJ; Bertagnolli MM. 2001. (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse. Cancer Res 61(1):118-25. PubMed: 11196148 MGI: J:67060
Weyant MJ; Carothers AM; Mahmoud NN; Bradlow HL; Remotti H; Bilinski RT; Bertagnolli MM. 2001. Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis. Cancer Res 61(6):2547-51. PubMed: 11289129 MGI: J:68469
Whelan J; Chiu CH; McEntee MF. 1999. Intestinal tumor load in the Min/+ mouse model is not correlated with eicosanoid biosynthesis Adv Exp Med Biol 469:607-15. PubMed: 10667389 MGI: J:60815
White JP; Baltgalvis KA; Puppa MJ; Sato S; Baynes JW; Carson JA. 2011. Muscle oxidative capacity during IL-6-dependent cancer cachexia. Am J Physiol Regul Integr Comp Physiol 300(2):R201-11. PubMed: 21148472 MGI: J:169040
White JP; Puppa MJ; Gao S; Sato S; Welle SL; Carson JA. 2013. Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK. Am J Physiol Endocrinol Metab 304(10):E1042-52. PubMed: 23531613 MGI: J:198215
White JP; Puppa MJ; Narsale A; Carson JA. 2013. Characterization of the male ApcMin/+ mouse as a hypogonadism model related to cancer cachexia. Biol Open 2(12):1346-53. PubMed: 24285707 MGI: J:205273
Wieczorek E; Jablonska E; Wasowicz W; Reszka E. 2015. Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review. Tumour Biol 36(1):163-75. PubMed: 25352026 MGI: J:235551
Wilding J; Straub J; Bee J; Churchman M; Bodmer W; Dickson C; Tomlinson I; Ilyas M. 2002. Cyclin D1 Is Not an Essential Target of beta-Catenin Signaling During Intestinal Tumorigenesis, but It May Act as a Modifier of Disease Severity in Multiple Intestinal Neoplasia (Min) Mice. Cancer Res 62(16):4562-5. PubMed: 12183406 MGI: J:78500
Wilkinson RW; Ross EL; Poulsom R; Ilyas M; Straub J; Snary D; Bodmer WF; Mather SJ. 2001. Antibody targeting studies in a transgenic murine model of spontaneous colorectal tumors. Proc Natl Acad Sci U S A 98(18):10256-60. PubMed: 11517330 MGI: J:71304
Williams JL; Kashfi K; Ouyang N; del Soldato P; Kopelovich L; Rigas B. 2004. NO-donating aspirin inhibits intestinal carcinogenesis in Min (APC(Min/+)) mice. Biochem Biophys Res Commun 313(3):784-8. PubMed: 14697260 MGI: J:87459
Williams MV; Lee SH; Pollack M; Blair IA. 2006. Endogenous lipid hydroperoxide-mediated DNA-adduct formation in min mice. J Biol Chem 281(15):10127-33. PubMed: 16449227 MGI: J:112310
Wilson CH; McIntyre RE; Arends MJ; Adams DJ. 2010. The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways. Oncogene 29(32):4567-75. PubMed: 20531296 MGI: J:168378
Wilson CL; Heppner KJ; Labosky PA; Hogan BL; Matrisian LM. 1997. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc Natl Acad Sci U S A 94(4):1402-7. PubMed: 9037065 MGI: J:38609
Wilson JE; Petrucelli AS; Chen L; Koblansky AA; Truax AD; Oyama Y; Rogers AB; Brickey WJ; Wang Y; Schneider M; Muhlbauer M; Chou WC; Barker BR; Jobin C; Allbritton NL; Ramsden DA; Davis BK; Ting JP. 2015. Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. Nat Med 21(8):906-13. PubMed: 26107252 MGI: J:228671
Wilson JM; Coletta PL; Cuthbert RJ; Scott N; MacLennan K; Hawcroft G; Leng L; Lubetsky JB; Jin KK; Lolis E; Medina F; Brieva JA; Poulsom R; Markham AF; Bucala R; Hull MA. 2005. Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology 129(5):1485-503. PubMed: 16285950 MGI: J:103661
Wilson JW; Deed RW; Inoue T; Balzi M; Becciolini A; Faraoni P; Potten CS; Norton JD. 2001. Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. Cancer Res 61(24):8803-10. PubMed: 11751402 MGI: J:73360
Wilson JW; Potten CS. 2000. The effect of exogenous prostaglandin administration on tumor size and yield in Min/+ mice. Cancer Res 60(16):4645-53. PubMed: 10969819 MGI: J:64010
Witherspoon M; Chen Q; Kopelovich L; Gross SS; Lipkin SM. 2013. Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine. Cancer Discov 3(9):1072-81. PubMed: 23771434 MGI: J:204238
Woo DK; Green PD; Santos JH; D'Souza AD; Walther Z; Martin WD; Christian BE; Chandel NS; Shadel GS. 2012. Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. Am J Pathol 180(1):24-31. PubMed: 22056359 MGI: J:180188
Wood PA; Yang X; Taber A; Oh EY; Ansell C; Ayers SE; Al-Assaad Z; Carnevale K; Berger FG; Pena MM; Hrushesky WJ. 2008. Period 2 mutation accelerates ApcMin/+ tumorigenesis. Mol Cancer Res 6(11):1786-93. PubMed: 19010825 MGI: J:224283
Xia D; Wang D; Kim SH; Katoh H; DuBois RN. 2012. Prostaglandin E2 promotes intestinal tumor growth via DNA methylation. Nat Med 18(2):224-6. PubMed: 22270723 MGI: J:181279
Xia F; Altieri DC. 2006. Mitosis-independent survivin gene expression in vivo and regulation by p53. Cancer Res 66(7):3392-5. PubMed: 16585159 MGI: J:108219
Xu C; Reichert EC; Nakano T; Lohse M; Gardner AA; Revelo MP; Topham MK; Stafforini DM. 2013. Deficiency of Phospholipase A2 Group 7 Decreases Intestinal Polyposis and Colon Tumorigenesis in ApcMin/+ Mice. Cancer Res 73(9):2806-16. PubMed: 23361301 MGI: J:196880
Xu H; Posner GH; Stevenson M; Campbell FC. 2010. Apc(MIN) modulation of vitamin D secosteroid growth control. Carcinogenesis 31(8):1434-41. PubMed: 20488884 MGI: J:162653
Xu H; Zhang Y; Pena MM; Pirisi L; Creek KE. 2017. Six1 promotes colorectal cancer growth and metastasis by stimulating angiogenesis and recruiting tumor-associated macrophages. Carcinogenesis 38(3):281-292. PubMed: 28199476 MGI: J:241877
Xue X; Ramakrishnan SK; Shah YM. 2014. Activation of HIF-1alpha does not increase intestinal tumorigenesis. Am J Physiol Gastrointest Liver Physiol 307(2):G187-95. PubMed: 24875099 MGI: J:221716
Xue X; Shah YM. 2013. Hypoxia-inducible factor-2alpha is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. Carcinogenesis 34(1):163-9. PubMed: 23042097 MGI: J:193648
Xue X; Taylor M; Anderson E; Hao C; Qu A; Greenson JK; Zimmermann EM; Gonzalez FJ; Shah YM. 2012. Hypoxia-inducible factor-2alpha activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res 72(9):2285-93. PubMed: 22419665 MGI: J:185744
Yamada T; Mori Y; Hayashi R; Takada M; Ino Y; Naishiro Y; Kondo T; Hirohashi S. 2003. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. Cancer Res 63(5):895-901. PubMed: 12615699 MGI: J:82288
Yamada Y; Hata K; Hirose Y; Hara A; Sugie S; Kuno T; Yoshimi N; Tanaka T; Mori H. 2002. Microadenomatous lesions involving loss of apc heterozygosity in the colon of adult apc(min/+) mice. Cancer Res 62(22):6367-70. PubMed: 12438216 MGI: J:80301
Yamada Y; Jackson-Grusby L; Linhart H; Meissner A; Eden A; Lin H; Jaenisch R. 2005. Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc Natl Acad Sci U S A 102(38):13580-5. PubMed: 16174748 MGI: J:101415
Yamada Y; Mori H. 2007. Multistep carcinogenesis of the colon in Apc(Min/+) mouse. Cancer Sci 98(1):6-10. PubMed: 17052257 MGI: J:120998
Yamaguchi K; Cekanova M; McEntee MF; Yoon JH; Fischer SM; Renes IB; Van Seuningen I; Baek SJ. 2008. Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways. Mol Cancer Ther 7(9):2779-87. PubMed: 18790758 MGI: J:152123
Yang K; Fan KH; Lamprecht SA; Edelmann W; Kopelovich L; Kucherlapati R; Lipkin M. 2005. Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc(1638 N/+) Mlh1(+/-) double mutant mice. Int J Cancer 116(4):495-9. PubMed: 15818612 MGI: J:99671
Yang K; Popova NV; Yang WC; Lozonschi I; Tadesse S; Kent S; Bancroft L; Matise I; Cormier RT; Scherer SJ; Edelmann W; Lipkin M; Augenlicht L; Velcich A. 2008. Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation. Cancer Res 68(18):7313-22. PubMed: 18794118 MGI: J:141219
Yang X; Wood PA; Ansell CM; Ohmori M; Oh EY; Xiong Y; Berger FG; Pena MM; Hrushesky WJ. 2009. Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice. J Biochem 145(3):289-97. PubMed: 19106159 MGI: J:149073
Yao LM; He JP; Chen HZ; Wang Y; Wang WJ; Wu R; Yu CD; Wu Q. 2012. Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis. Carcinogenesis 33(2):301-11. PubMed: 22159226 MGI: J:181110
Yekkala K; Baudino TA. 2007. Inhibition of intestinal polyposis with reduced angiogenesis in ApcMin/+ mice due to decreases in c-Myc expression. Mol Cancer Res 5(12):1296-303. PubMed: 18171987 MGI: J:134087
Yerushalmi HF; Besselsen DG; Ignatenko NA; Blohm-Mangone KA; Padilla-Torres JL; Stringer DE; Cui H; Holubec H; Payne CM; Gerner EW. 2006. The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis. Mol Carcinog 45(2):93-105. PubMed: 16329147 MGI: J:107079
Yerushalmi HF; Besselsen DG; Ignatenko NA; Blohm-Mangone KA; Padilla-Torres JL; Stringer DE; Guillen JM; Holubec H; Payne CM; Gerner EW. 2006. Role of polyamines in arginine-dependent colon carcinogenesis in Apc(Min) (/+) mice. Mol Carcinog 45(10):764-73. PubMed: 16705737 MGI: J:115819
Yokomine K; Nakatsura T; Senju S; Nakagata N; Minohara M; Kira J; Motomura Y; Kubo T; Sasaki Y; Nishimura Y. 2007. Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in Apc(Min/+) mice. Cancer Sci 98(12):1930-5. PubMed: 17892515 MGI: J:129988
Yoshida M; Zhao L; Grigoryan G; Shim H; He P; Yun CC. 2016. Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24. Am J Physiol Gastrointest Liver Physiol 310(8):G586-98. PubMed: 26867566 MGI: J:234305
You S; Ohmori M; Pena MM; Nassri B; Quiton J; Al-Assad ZA; Liu L; Wood PA; Berger SH; Liu Z; Wyatt MD; Price RL; Berger FG; Hrushesky WJ. 2006. Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol 87(3):227-36. PubMed: 16709231 MGI: J:122752
Young LE; Moore AE; Sokol L; Meisner-Kober N; Dixon DA. 2012. The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2. Mol Cancer Res 10(1):167-80. PubMed: 22049153 MGI: J:205397
Yu CF; Whiteley L; Carryl O; Basson MD. 2001. Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice. Dig Dis Sci 46(7):1367-80. PubMed: 11478486 MGI: J:70920
Yue HH; Diehl GE; Winoto A. 2005. Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice. Cell Death Differ 12(1):94-7. PubMed: 15514675 MGI: J:94118
Yum MK; Kang JS; Lee AE; Jo YW; Seo JY; Kim HA; Kim YY; Seong J; Lee EB; Kim JH; Han JM; Kim S; Kong YY. 2016. AIMP2 Controls Intestinal Stem Cell Compartments and Tumorigenesis by Modulating Wnt/beta-Catenin Signaling. Cancer Res 76(15):4559-68. PubMed: 27262173 MGI: J:234840
Yusta B; Holland D; Waschek JA; Drucker DJ. 2012. Intestinotrophic glucagon-like peptide-2 (GLP-2) activates intestinal gene expression and growth factor-dependent pathways independent of the vasoactive intestinal peptide gene in mice. Endocrinology 153(6):2623-32. PubMed: 22535770 MGI: J:188646
Zechel JL; Doerner SK; Lager A; Tesar PJ; Heaney JD; Nadeau JH. 2013. Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis. BMC Genet 14:54. PubMed: 23773267 MGI: J:221231
Zeilstra J; Joosten SP; Dokter M; Verwiel E; Spaargaren M; Pals ST. 2008. Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res 68(10):3655-61. PubMed: 18483247 MGI: J:135025
Zeilstra J; Joosten SP; van Andel H; Tolg C; Berns A; Snoek M; van de Wetering M; Spaargaren M; Clevers H; Pals ST. 2014. Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling. Oncogene 33(5):665-70. PubMed: 23318432 MGI: J:204874
Zeineldin M; Cunningham J; McGuinness W; Alltizer P; Cowley B; Blanchat B; Xu W; Pinson D; Neufeld KL. 2012. A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression. Oncogene 31(19):2423-37. PubMed: 21996741 MGI: J:186132
Zeineldin M; Jensen D; Paranjape SR; Parelkar NK; Jokar I; Vielhauer GA; Neufeld KL. 2014. Human cancer xenografts in outbred nude mice can be confounded by polymorphisms in a modifier of tumorigenesis. Genetics 197(4):1365-76. PubMed: 24913681 MGI: J:216876
Zeineldin M; Neufeld KL. 2013. Understanding phenotypic variation in rodent models with germline Apc mutations. Cancer Res 73(8):2389-99. PubMed: 23580574 MGI: J:197040
Zeitels LR; Acharya A; Shi G; Chivukula D; Chivukula RR; Anandam JL; Abdelnaby AA; Balch GC; Mansour JC; Yopp AC; Richardson JA; Mendell JT. 2014. Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis. Genes Dev 28(23):2585-90. PubMed: 25395662 MGI: J:217396
Zell JA; Ignatenko NA; Yerushalmi HF; Ziogas A; Besselsen DG; Gerner EW; Anton-Culver H. 2007. Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival. Int J Cancer 120(3):459-68. PubMed: 17096347 MGI: J:117825
Zeng Q; Phukan S; Xu Y; Sadim M; Rosman DS; Pennison M; Liao J; Yang GY; Huang CC; Valle L; Di Cristofano A; de la Chapelle A; Pasche B. 2009. Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development. Cancer Res 69(2):678-86. PubMed: 19147584 MGI: J:143706
Zeytin HE; Patel AC; Rogers CJ; Canter D; Hursting SD; Schlom J; Greiner JW. 2004. Combination of a poxvirus-based vaccine with a cyclooxygenase-2 inhibitor (celecoxib) elicits antitumor immunity and long-term survival in CEA.Tg/MIN mice. Cancer Res 64(10):3668-78. PubMed: 15150127 MGI: J:90258
Zhang S; Li L; Kendrick SL; Gerard RD; Zhu H. 2014. TALEN-mediated somatic mutagenesis in murine models of cancer. Cancer Res 74(18):5311-21. PubMed: 25070752 MGI: J:215988
Zhang T; Nanney LB; Luongo C; Lamps L; Heppner KJ; DuBois RN ; Beauchamp RD. 1997. Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res 57(1):169-75. PubMed: 8988060 MGI: J:37447
Zhang T; Nanney LB; Peeler MO; Williams CS; Lamps L; Heppner KJ; DuBois RN; Beauchamp RD. 1997. Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. Cancer Res 57(9):1638-43. PubMed: 9134999 MGI: J:40133
Zheng W; Wong KE; Zhang Z; Dougherty U; Mustafi R; Kong J; Deb DK; Zheng H; Bissonnette M; Li YC. 2012. Inactivation of the vitamin D receptor in APC(min/+) mice reveals a critical role for the vitamin D receptor in intestinal tumor growth. Int J Cancer 130(1):10-9. PubMed: 21328347 MGI: J:178583
Zhong Y; Krisanapun C; Lee SH; Nualsanit T; Sams C; Peungvicha P; Baek SJ. 2010. Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53. Eur J Cancer 46(18):3365-74. PubMed: 20709524 MGI: J:166565
Zhou WJ; Geng ZH; Spence JR; Geng JG. 2013. Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection. Nature 501(7465):107-11. PubMed: 23903657 MGI: J:204377
Zhu H; Dougherty U; Robinson V; Mustafi R; Pekow J; Kupfer S; Li YC; Hart J; Goss K; Fichera A; Joseph L; Bissonnette M. 2011. EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators. Mol Cancer Res 9(7):960-75. PubMed: 21653642 MGI: J:205224
Ziegler CC; Rainwater L; Whelan J; McEntee MF. 2004. Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. J Nutr 134(1):5-10. PubMed: 14704285 MGI: J:88124
Zimmermann S; Kiefer F; Prudenziati M; Spiller C; Hansen J; Floss T; Wurst W; Minucci S; Gottlicher M. 2007. Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice. Cancer Res 67(19):9047-54. PubMed: 17909008 MGI: J:152134
de Jesus Perez VA; Yuan K; Orcholski ME; Sawada H; Zhao M; Li CG; Tojais NF; Nickel N; Rajagopalan V; Spiekerkoetter E; Wang L; Dutta R; Bernstein D; Rabinovitch M. 2012. Loss of adenomatous poliposis coli-alpha3 integrin interaction promotes endothelial apoptosis in mice and humans. Circ Res 111(12):1551-64. PubMed: 23011394 MGI: J:212880
de Jong PR; Takahashi N; Harris AR; Lee J; Bertin S; Jeffries J; Jung M; Duong J; Triano AI; Lee J; Niv Y; Herdman DS; Taniguchi K; Kim CW; Dong H; Eckmann L; Stanford SM; Bottini N; Corr M; Raz E. 2014. Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest 124(9):3793-806. PubMed: 25083990 MGI: J:215766
de Wind N; Dekker M; van Rossum A; van der Valk M; te Riele H. 1998. Mouse models for hereditary nonpolyposis colorectal cancer. Cancer Res 58(2):248-55. PubMed: 9443401 MGI: J:45433
de la Roche M; Ibrahim AE; Mieszczanek J; Bienz M. 2014. LEF1 and B9L shield beta-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. Cancer Res 74(5):1495-505. PubMed: 24419084 MGI: J:208159
van Kranen HJ; van Iersel PW; Rijnkels JM; Beems DB; Alink GM; van Kreijl CF. 1998. Effects of dietary fat and a vegetable-fruit mixture on the development of intestinal neoplasia in the ApcMin mouse. Carcinogenesis 19(9):1597-601. PubMed: 9771930 MGI: J:49892
van der Weyden L; Arends MJ; Dovey OM; Harrison HL; Lefebvre G; Conte N; Gergely FV; Bradley A; Adams DJ. 2008. Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis. Oncogene 27(32):4503-8. PubMed: 18391979 MGI: J:138515

Also Known As: Min, multiple intestinal neoplasia

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

ApcMin

Allele Symbol: ApcMin

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: ApcMin related

Mammalian Phenotype Terms by Genotype

Genotype: ApcMin/Apc+B6(AKR)-ApcMin

digestive/alimentary phenotype

mortality/aging

neoplasm

reproductive system phenotype

hematopoietic system phenotype

endocrine/exocrine gland phenotype

integument phenotype

Genotype: ApcMin/Apc+C57BL/6J-ApcMin

mortality/aging

neoplasm

digestive/alimentary phenotype

homeostasis/metabolism phenotype

liver/biliary system phenotype

growth/size/body region phenotype

hematopoietic system phenotype

immune system phenotype

Genotype: ApcMin/Apc+involves: C57BL/6J

integument phenotype

mortality/aging

neoplasm

digestive/alimentary phenotype

cellular phenotype

endocrine/exocrine gland phenotype

hematopoietic system phenotype

Genotype: ApcMin/Apc+involves: C57BL/6 * C57BL/6J

mortality/aging

digestive/alimentary phenotype

Genotype: ApcMin/ApcMininvolves: C57BL/6J

cellular phenotype

Genotype: ApcMin/Apc+B6.Cg-Brca2tm1Mbn ApcMin

growth/size/body region phenotype

reproductive system phenotype

neoplasm

endocrine/exocrine gland phenotype

integument phenotype

Genotype: ApcMin/Apc+(AKR/J x C57BL/6J-ApcMin)F1

mortality/aging

neoplasm

digestive/alimentary phenotype

cellular phenotype

homeostasis/metabolism phenotype

Genotype: ApcMin/Apc+(MA/MyJ x C57BL/6J-ApcMin)F1

mortality/aging

neoplasm

digestive/alimentary phenotype

Genotype: ApcMin/Apc+involves: AKR/J * C57BL/6J

neoplasm

digestive/alimentary phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

mortality/aging

Genotype: ApcMin/Apc+involves: 129P2/OlaHsd * C57BL/6

neoplasm

digestive/alimentary phenotype

Genotype: ApcMin/Apc+involves: 129/Sv * C57BL/6

digestive/alimentary phenotype

hematopoietic system phenotype

immune system phenotype

Genotype: ApcMin/ApcMininvolves: AKR/J * C57BL/6J

embryo phenotype

growth/size/body region phenotype

Genotype: ApcMin/ApcMininvolves: C57BL/6 * POMOD

Apc^Min

Allele Symbol: Apc^Min

Genotype: Apc^Min related

Genotype: Apc^Min/Apc⁺
B6(AKR)-Apc^Min

Genotype: Apc^Min/Apc⁺
C57BL/6J-Apc^Min

Genotype: Apc^Min/Apc⁺
involves: C57BL/6J

Genotype: Apc^Min/Apc⁺
involves: C57BL/6 * C57BL/6J

Genotype: Apc^Min/Apc^Min
involves: C57BL/6J

Genotype: Apc^Min/Apc⁺
B6.Cg-Brca2^tm1Mbn Apc^Min

Genotype: Apc^Min/Apc⁺
(AKR/J x C57BL/6J-Apc^Min)F1

Genotype: Apc^Min/Apc⁺
(MA/MyJ x C57BL/6J-Apc^Min)F1

Genotype: Apc^Min/Apc⁺
involves: AKR/J * C57BL/6J

Genotype: Apc^Min/Apc⁺
involves: 129P2/OlaHsd * C57BL/6

Genotype: Apc^Min/Apc⁺
involves: 129/Sv * C57BL/6

Genotype: Apc^Min/Apc^Min
involves: AKR/J * C57BL/6J

Genotype: Apc^Min/Apc^Min
involves: C57BL/6 * POMOD

Genotype: Apc^Min/Apc^Min
involves: C57BL/6J * CAST/EiJ

Additional - Apc^Min related